skysight-inc/HackerNews huggingface dataset:
originally i was going to write this entire trial off as a pharma industry snow job with heavily contrived data -- and it still might be -- but i think there's probably at least something worth talking about here.

the drug slows progression, allegedly by clearing amyloid plaques. in one sense, that is not enough. alzheimer's still wins in the long run. in another sense, it's a big improvement in the state of the science and clinical practice. the stuff we were using to try to slow the progression of alzheimer's before was largely ineffective. trials like this shed light on fundamental research questions while hopefully helping patients at the same time.

on the other hand, if the progression is slowed at the cost of a large drop in patient quality of life, it may not be worth it clinically in the present state. there's no indication that this is the case, but i wouldn't rule it out until we have more data. there seem to be allergic reactions and potential brain swelling as side effects of the therapy. personally, i would predict that these effects are far more common than is being currently reported. that doesn't mean the therapy is useless, just that it has consequences like any other therapy does.

finally, the amyloid hypothesis has come under a lot of scrutiny recently. as the article points out, removing most plaques does not lead to a cured patient, merely an improvement -- but not an improvement which brings the patient back to normal function. if this trial ends up falling through, it might be the end of the amyloid hypothesis in clinical practice and drug development. that would be a step forward towards a greater understanding... but also very discouraging because we'd need to discard a lot of what we were assuming was the canon up to this point.
What are you currently doing to handle licensing outside of Paddle? I'm guessing you're building an Electron app?
the same is true about js really.
Username is hn50

Many thanks.

I remember running Spice on an 8086... The day I bought an 8087 coprocessor...it was SOOOOO much faster!
Removing malaria-carrying mosquitoes unlikely to affect ecosystems
For those interested in this sort of thing, 'packing' and 'impect' are also interesting to read about, developed in Germany but it still hasn't widely spread into the mainstream like more traditional stats like possession, pass completion %, or meters run. These traditional stats very often do not explain why team A or B actually won the game. Therefore, two new statistical measures were developed, which better explain why a particular team won a game.

Packing is the measurement of how many opposition players are beaten by a pass (or dribble or other move).

Impect is the number of deep lying defenders beaten, which is obviously more valuable compared to high pressing strikers.

The key insight is that defenders beaten, particularly deeper-lying defenders are the measurement needed to identify who is expected to win (and therefore assessing the value of passing players, or defenders).

http://bundesligafanatic.com/20160610/impect-packing-the-fut...
British man unwittingly gave Russian nerve agent to his girlfriend as a gift
I've made an app that creates blogs from Telegram channels.

Telepost is free. I offer plus account that allows having a custom domain with free SSL powered by Let's Encrypt, embed Google Analytics or have comments, just for €200/year.

If you're interested, hit me at https://t.me/kossnocorp
Is vSphere Essentials Plus supported as we have a good use case. Are there any specific additional requirements eg. vsan or does it all run on the base Esxi product?
That's great, but we really need something like this that can allow us to simulate microcontrollers / raspberry pi. Development would become really simple for us software guys then !
Perhaps you should re-read the OPs comment:

>"They have consciously destroyed a generation attention span using psychological tricks"

MTV at the height of music videos in 1980s and 1990s was never accused of using "psychological tricks."
>his was an innovation, in that previously we could only get that kind of money together for war projects. So I see space as the poetics that saves us from spending all our money on war.

Hang on, you actually believe that the space program wasn't a "war project"? LMAO, I honestly envy your delusion.
Prototyping a new idea: the story of our tech stack
> Or in O(1)

You mean in one instruction? The parent comment is O(1). The methods in the article are all O(1) too.
>Something that is predetermined can be influenced. See a collision of 2 balls in Newtonian universe - it's predetermined, yet you're justified in saying "collision influenced paths of these balls".

Not beyond its initial cause. If free will doesn't exist (in the universe), then nothing that happens after our birth can influence it.

(A fundamental existence of free will is not the same scenario with e.g. taking a person and specifically (e.g. surgically) alter them to not have free will).
Facebook takes down right-wing fake news network ahead of Brazil election
I suspect a lot of early internet amateur animators got started on pirated/shared versions of Flash. Probably helped the proliferation of that scene a whole lot. Cloud based service models make that much harder.
https://exercism.io

Learn virtually any programming language by completing series of puzzles. Tests are all written for you. They just made a huge overhaul of their UX, and it’s really nice looking. I’m using it to try to learn Rust and Elixir at the moment.
Amazon's Rekognition Misidentifies 28 Members of Congress as Suspected Criminals
The answer is in the paragraph you quoted from. "work with" includes extending the implementation.
Check out their new Stories program if you haven’t yet. I've found it to be a refreshing change of pace, compared to the typical lessons. As the name implies, you're presented a story, and after each sentence, they quiz you on the meaning of the sentence that you just encountered.

https://stories.duolingo.com
>Ultimately it still boils down to you and your own brain, not anyone else.

Are you really suggesting one's social environment has no effect on one's social behavior? Because that is obviously false.
No, that probably isn't a can of breakfast pizza, just looks like a recipe that's usually printed on cans of vegetables. Further, if you were worried that breakfast pizza was something unusual, it's just normal pizza, not specifically for breakfast, but using breakfast ingredients (eggs, bacon, potatoes.) Often times cans of vegetables include a recipe to... fill space? Provide value?

The can itself looks like a can of olives (warning at the bottom says to watch out for pits, the ingredient line for olives is very specific as to what type of olives to use, olives are fruits in a botanical sense.)
Microservices and Tech Stack – Lessons Learned
That's classic whataboutism. Obama has nothing to do with this.
YouTube removes four Alex Jones videos for hate speech, child endangerment
I had a better understanding once I looked at the github repository, https://github.com/rsuite/rsuite
It's a can of olives.

EDIT: specifically, this: https://www.instacart.com/stop-shop/products/3191201-sb-medi...
Well, to be blunt, you don't have a story without a protagonist and a problem. And if you don't have a story, you don't have a reader. If you don't have readers, then there isn't much point in writing.

So you don't see much popular journalism without a protagonist and a problem. I dunno if that's good or bad, but that's what we have and there are reasons for that situation.
Circuit scramble is a fun game on Android for learning and visualizing logic circuits. It's not directly relevant to anything I do, but I enjoyed playing through it.

Factorio does a decent job teaching the intuition behind running a factory.
yeah, i got this feeling too. the drug companies are desperate to make money off of alzheimer's, but the disease is too obstinate to go along with their wishes unless they juke the stats.

improving cognitive function is very difficult under any circumstance. making a drug that alters a biomarker reliably is, in comparison, very easy.

of course, if the biomarker doesn't have a strong correlate to health, it won't help the patient. but they would prefer to sell drugs that "work" without improving the patient's quality of life if it is between that and not selling any drugs.

the other reason that these interventions are always so focused on "early" or "preclinical" alzheimer's is because that's when the patient's brain is still more neurotypical than not. as the disease progresses, i get the feeling that many of the normal rules of thumb regarding brain function and drug action in the brain start to fall through, which makes therapy development far harder.
> Now the casual pot smoker or the "one beer after work" drinker is not causing trouble for society.

> At the same time, they are the ones most likely stopping consumption should the substance become illegal.

What makes you say that? Over 100,000,000 Americans have tried marijuana, which largely remains illegal.
Amazon’s facial recognition matched 28 members of Congress to criminal mugshots
It's like the funnel intro format everyone gets hammered into writing while in school. I never cared for it, and now have to filter it out when reading articles. It's pure noise rather than adding to the content.
I have collected a few here. Mostly around topics of programming.

https://github.com/dakaraphi/development-resources/blob/mast...
I've always used gcc on all platforms for C and C++, but since last year I also use clangformat.

On the other hand, the effort of learning clang options, error messages and paths in order to have two compilers available can wait indefinitely until I really need a second opinion about some compilation error; so far it hasn't happened.
> To reiterate: WASM does not require you to drop down to canvas or render fonts yourself.

The fear isn't that it requires that. The fear is that it enables that.

The web is, and has been over the past two decades, in the constant state of war over control between publishers and consumers. People - and especially businesses - making pages would like to have 100% control over how the webpage/app looks and is being used. But the users would like to have some control over what they're viewing too[0].

The most widely known battle in this war is the battle for ad-blocking. The publishers want you to view lots of ads. You want just the content, without any of the ads. So far, the technology (and economics) favors the user, but it's not a given.

The balance of control on the web was always maintained by the technologies on which the web standardized on. Pure HTML, or even HTML+CSS, strongly favours the user. JavaScript tilts the balance significantly towards the publishers, as now they can (and do) generate content with code, which renders the page difficult to interpret and modify on the user end. One of the biggest complaints about Flash was how shitty the pure-Flash/mostly-Flash webpages were. That's not an intrinsic problem of Flash - this happened, because Flash gave the publishers too much control. And publishers (again, especially businesses) will use (and abuse) any control they're given.

The fear here is, that WASM against tilts the control in favour of publishing, which will lead to abuse and web becoming a much worse place for the consumers. If WASM will, by virtue of efficiency, enable publishers to embed a browser they control within the page, the publishers will use this, because this would single-handedly eliminate most ad-blocking, userscripting and scrapping efforts.

--

[0] - and the power users, like myself, would like to have 100% of that control - think of how much better the web would be if the data was always published in machine-readable format, without tons of bullshit paginations and stylistic choices to scroll and click through. For instance, when looking for current weather, I want to input my location and a time span, and get weather data. I want to be able to script that. I don't want to waste time looking at ads, pretty pictures, non-relevant text and links.
A computer doesn't take any "free will" decision of its own -- everything is determined at the time the program is written/loaded.

"Doing X if Y" is not a free will decision if it's already encoded. In a sense it's not a decision at all. When X, the computer will do Y, period.

(And this also applies if we add some stohastic elements in the mix).
The most verbose type of template errors I can think of are instantiation errors with multiple candidates and type deduction failures.
In these cases there won't be any elision so it won't help much.

I still hope one day we'll see GCC & clang implement some kind of parsable diagnostic output (e.g JSON).
Simply folding all the candidates on a UI would be a massive step forward in reading template errors.
Yes, but only for about four hours a day, because naps.
> It looks like it was "too hard" so standards are being lowered.

Not at all. It turns out one of the standards was not relevant to the target population. As you quoted: "This is because in early cases of Alzheimer’s, patients may have the biological indicators of the disease without actually showing symptoms."

There's no point in trying to alleviate symptoms where there are no symptoms. If I develop a drug that removes tumors that eventually caused headaches, is it somehow lowering standards if it removes tumors before a headache appears?
They're not being demoted for being Republican. They're a small minority of Republicans being demoted for repugnant tweets.

They're not being shadowbanned or prevented from tweeting.

http://nymag.com/selectall/2018/07/twitter-is-not-shadow-ban...
Well if you have a drug to catch someone early and they have no measurable decline in cognitive ability how would you ever have a drug that prevents the disease get passed?
Compiling C++ or Rust to use in a web page is much more complicated than just writing Javascript. I can't see how that lowers the barrier to entry. Your argument seems to be that you can do more with those platforms because they're more performant, which yeah, to a point I guess, but Javascript is already plenty fast for making whatever obnoxious dreams people want to come true and the web seems to have survived it fine.
Decade-old Bluetooth flaw lets hackers steal data passing between devices
Some definitions from my understanding: "isomorphic" - can render on server and client side with same code, "virtual dom" - non-browser DOM, i.e. often just a HTML data model useful for mutating and then diffing to minimize changes to the page DOM, "dom" - the data model of the page.
True randomness is also beyond the control of the individual so it's not a "will".
Assuming that law enforcement is going to spend any amount of time being careful about enforcing correct use of forensic tools is hard to reconcile with the history of the American judicial system. For example, there is essentially no scientific evidence that a polygraph test measures anything at all, but polygraph evidence is considered admissible in many courts and used to be admitted in many more. Moreover, rigorous studies of fingerprint evidence have found them to have false positive rates as high as 1 in 18, but they are still often treated as close to infallible in court. I am not sure why you think facial recognition is going to be different.
Heads up, there's something already called Percy in the JS space. https://percy.io
Wonder what its effect on the popularity of Javascript will be, given that it can be used as a compilation target for pretty much any language (?).
Millennials Are Making a Costly Investment Mistake
I wish I had good recommendations for you. Quanta can be quite good, but it misses sometimes. Most coverage of fundamental physics, especially theory, fails (for obvious reasons) to provide the key context that progress in the field is very slow and getting slower.

There are a few excellent specialist blogs, like Resonaances for particle physics,

http://resonaances.blogspot.com/

but they are not very accessible to outsiders. Sean Carroll, Sabine Hossenfelder, and Peter Woit are pretty good and accessible

http://www.preposterousuniverse.com/blog/
http://backreaction.blogspot.com/ http://www.math.columbia.edu/~woit/wordpress/

but they aren't neutral; that's fine since they are personal blogs, but it can be difficult for laymen to get an objective picture of the field.
Why did they have to turn HOPE into social justice and virtue-signalling? The author needs to tone it down and focus his dislike for just those who caused all this and stop painting groups of people with such a broad brush. No, hacking was not about social justice. It was about learning and creating. Hackers don't give a damn about how society "feels" or how "justice" is so important. You can still be a social justice warrior if you are a hacker but stop tying the two together because it is just you and your crowd that cares. The rest of us will look dispassionately on your virtue-signalling rainbows and skittles world and then go back to assembling or compiling some new code that talks to something that makes things happen while trying to survive on this Salusa Secondus or on Giedi Prime prison planet world(s) Don't blindly hate because then you are the Nazi.
>Three, after Britain was shut out of the trade China seemingly already had a massive local supply.

As mentioned, smuggling became a huge business, and it wasn't too hard. The UK had a massive land border with China, China has a huge coastline with pirates controlling the seas/major rivers, which also allowed towns to ignore Beijing's orders. There was not a major local supply.

> Two, how did merchants at the ports create demand in the interior, surely they met demand outcompeting local sources on cost and so widening the market.

The Yangtze and Yellow rivers.
How the hell do you retain any accessibility when rendering a custom UI in Canvas?
Society's honestly not becoming particularly polarized, on anything remotely like a historical scale. To take US history, for example, I can think of several times in the past century alone that the public sphere was more acrimonious.

I haven't made much of a study of primary sources, but I wouldn't be surprised if a common thing that happened every one of those times was that people would start trying to figure out how to turn "appeal to acrimony" into a convincing debate tactic.
If anyone wants to take a quick look at running a WASM app to take your understanding from theoretical to applied look no further than Fabrice Bellard's excellent BPG Image format and the JS decoders which build for asm.js and wasm.
Funny to stumble across this on Hacker News.

I'm the analyst mentioned in the article. Happy to answer any questions about our weird little industry.
Not necessarily. In the world of desktop software, most users know what a file is, and know that all the data of what they've been working at the moment on is contained within such a file. They know they can move this file around and possibly send to whomever they want. They also know that a file can be opened by multiple applications.

SaaS and web kill that.
This is a fine sentiment at small scale, but once a service becomes significant, close to mandatory, in daily life, the other aspects become overwhelming.

For sake of example, as much as I detest various extremists [†], I would strongly oppose blocking[‡] the extremists from local power company's electric grid (which is a publicly traded stock company in here), from the local telephone exchange (which in my city is a public-private partnership, IIRC), or yes, from the most popular microbloging platform out there. In 2018, Twitter access is about as necessary as phone exchange access in 1990s.

200 years ago cutting off either would have been fine, a non-issue really, as there was infrastructure, services, and knowledge & skills in place to lead normal life without electricity, running water, comms, etc.. But right now one doesn't simply go about the necessities of daily life - work, shopping, health care, etc. - without electricity and fast communications.

There's two competing approaches to the problem of extremism, hate, and disinformation: either "giving them voice empowers them", or "sunlight is the best disinfectant / let them speak so everybody can see their idiocy", and I happen to firmly belong in the later camp. From my POV, we aren't experiencing increase in extremism right now - quite the opposite; thanks to the modern tools we've noticed how bad it used to be in the hiding, and are successfully fixing the problems now that they surfaced.

I shed no tears for all the Twitters, Facebooks, Googles, etc. fall victims to their own success - becoming so successful they became widely considered necessities. They are still quite profitable with all the problems that causes, and all the constraints it puts on them. And that's not necessarily permanent state either; going by historical examples, access to MS Windows, or ability to listen to radio, or access to horse pastures used to be such necessities back in their heyday, but aren't terribly important anymore.

[†] that is not to imply republicans are extremists.

[‡] outside of criminal activity, which is mostly accepted as fair ground for bans and content removal - but is neither specific, nor unique, to trolls, haters, or extremists.
Experts tackle the phenomenon of angry men and trolls who hover around games
Klabnik makes a strong case for WASM here, and one I haven't really seen anywhere else.

Now the question is, who will make the first major framework on top of WASM, and for which language?
Chinese Citizens Are Using Ethereum to Warn Each Other of Unsafe Vaccines
Good question. There are more than one argument but I will use the security one: in a public blockchain, the blockchain is the truth and if a transaction happens it is immutable under certain assumptions. The connection between a public blockchain and the real world is through oracles which are the weakest chain since no matter the blockchain security it could trigger transactions beyond it. Now, what happens in a private blockchain? In this context there are a lot of outside the blockhain organizational systems that if they are being attacked all the blockchain security does not matter.
Only 28? Should be a complete 1:1, meaning they all seem crooked in one way or another...
Nix, Docker and Haskell
http://lyricstraining.com does language teaching by having you watch/listen to music videos in that language on youtube and filling in the lyrics. Super fun!
Local hidden variables have been disproven. Non-local ones are an entirely valid solution.
Allowing a company to use your code how they want doesn't take away anyone else's freedom to use your code how they want. Its an absurd and comparison and claim; in what way are you taking away someones freedoms by using a permissive license? please explain, as your previous claim that anyone can take the rights to your project is incorrect
Western philosophy predates the Christian belief system. It's slightly more accurate to say Christianity was influenced by western culture than western culture was influenced by Christianity. (Though clearly adoption occurred in both directions.)

Christmas trees and holly are obvious, but compare old vs new testament and it's much deeper than that. On top of that you get the Protestant Revolution which really westernized Christianity.
Drug giant GSK teams up with DNA testing company 23andMe to design new drugs
Because clang got a LOT slower and GCC got a bit faster. clang used to be incredibly fast and used little memory consumption, but recent versions have seen the compiler regress in both areas. On the other hand clang does a lot more now than it used to so it's somewhat justified.

My own experience with a substantial codebase (1+ million lines of code) is MSVC uses the least amount of RAM, followed by clang and then GCC. For performance in terms of compiling/linking it's GCC/clang tied and then MSVC from fastest to slowest.
Honestly, about 60K to keep working for 3 years and then never again (for money, anyway).