skysight-inc/HackerNews huggingface dataset:
It reads to me like these medications are _not_ going to be classified as "over the counter." Even though they will not require a prescription, that's the whole point.

I wonder if the regulations are written in some way to allow them to keep charging prescription prices without a prescription. The article definitely suggests it's a new "status", not merely making more things OTC.

From the OP:

> Finding a way to expand access to widely used prescription drugs has been a goal of regulators in recent years.

> The FDA explored the idea of a “behind-the-counter” designation in 2007 that would have required interaction with a pharmacist. The Government Accountability Office in a 2009 report on the proposal asked whether consumers would end up paying more for their drugs since nonprescription medications typically aren’t covered by insurance."

Note, since they aren't typically _covered by insurance_. A new designation that would be covered by insurance, fit into insurance schedules under "prescription", but not actually require a prescription -- hey, "everyone" wins!

From: https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/u...

"Currently, nonprescription drugs can be marketed under either of two regulatory pathways: the Over-the-Counter (OTC) Drug Review (OTC Monograph Process) or the New Drug Application (NDA) process, and there are different requirements under each system. Today’s new FDA draft guidance, Innovative Approaches for Nonprescription Drug Products, applies to drugs under the NDA process and is intended to extend that NDA pathway to include therapeutic indications that have not, historically, been available for use without a prescription."

The (very brief) draft guidance itself: https://www.fda.gov/downloads/Drugs/GuidanceComplianceRegula...
‘Star Citizen’ Court Case Reveals the Messy Reality of Crowdfunding a $200M Game
Thanks for speaking for the entire medical profession. That is in fact what a terrible physician does, and not what myself or other newly trained physicians aspire to do.
Canned Monkeys Don't Ship Well, the Remix Version
Is there a single cloud that can match uptime of a single top tier DC?
Arguably parser combinators satisfy the author's requirements, e.g. https://github.com/Geal/nom/
I think it's a competitive offering in the tech/startup interview(marketing)industry. Indie hackers was at least to me the first website to offer insight into how much companies were making as well as a nice narrative about how they started. It preys on many of us who would love to crank out a product and make passive income. Iirc indie hackers is owned by stripe now and only interviews people using stripe. The people who run these sites get paid by sponsors to either be interviewed or have ads on their inevitable podcast. It's a simple product if you are good at talking and convincing people to sit down and do some self marketing.
Can you elaborate why being able to embed objects within another void this hypothesis?
Today you can research drug interactions online just like many doctors do. I have to do this for the combination of supplements and the one prescription, since most doctors are not trained in this area.
Blockchains are not a solution here. This comment doesn't make much sense; your proposed solution is missing a lot of details.

If there was a simple solution to this problem there would not be insanely complicated packers that basically try to make their own instruction set.
If the player controls the CPU the code is running on, there is fundamentally no way to enforce they are actually running the code provided.
What position will you be interviewing for?
You are missing the point of Bell test experiments. Such experiments demonstrate that which guitar is the high E one and which is the low E one is not decided when they are still together. It is not that you and everyone else just don't know which way it is until someone listens to one of them, it is actually not yet decided until someone listens to one of them.
> There's a lot I don't like about Trump, but I think his tariffs really will make America great again

Tariffs won't do that.

Trade negotiation aimed at trade deals with strong common (not necessarily identical but converting over time) labor and environmental protections—where the partners with weaker protection in reach sub-area catch up over time to those starting out with stronger protection—so that competition is on a progrrssively leveling field, rather than a race to the bottom, would help.

Tariffs might have utility as leverage in such negotiations, but while this administration may make noises a better trade deals, they haven't shown interest in labor or environmental protections domestically or internationally, so they don't seem likely to use tariffs in the only way in which they might contribute to solving the problem rather than making it worse.
I use Quilt pretty much daily and while I like AWS open datasets I don't think it is as actively developed on as Quilt is. DAT project on the other hand I really do like as a way to simply transfer large amounts of data between contributors, that said, if you are just trying to get data out there and have people use it freely for their own work I think Quilt presents the solution due to searchable and easily understood python (and I think an R repo) usage of datasets.
I also use Notion and find it great so far! What do you mean by "they (inexplicably) decided to remove limits on mobile users"?
Something no one has mentioned yet, could it be that the engineering force at Google is no longer what it used to be?
That's an interesting excuse...

If the founders control the company, then they can dictate the terms of employee compensation. To a degree at least... I guess they cannot unilaterally make decisions that completely piss-off and alienate their investors, or good luck with series B.

If the VCs control the company, then I'm sure their response would be "we offer industry standard x% of equity, so there's no reason to offer more".

Chicken and egg problem. It won't change until someone changes it.

Another thought: Where would the increase in employee equity come from? Would the founders dilute their share, or expect all shareholders to dilute? If it's just the founders deciding to be more generous, then why should the board have a problem?
The board should be absolutely in favor of founder-only dilution, since it costs other investors nothing, and ostensibly results in a more motivated workforce.
Bad joke not withstanding, I think this speaks more to the one-sided nature of any "review" process. Places like Facebook love to tout the violation of their terms of service or community guidelines, but when there is no separation of enforcement and adjudication (review) and review processes takes place without your input then it becomes obvious that it's not a community but a structure for control.

This fallacy of the benevolent dictator that these internet overlords wish to push upon us is shown to be the emperor with no clothes.
> To use SQL, even an in memory one, in such use case is not going to work.

Have an index on the score and select with ORDER BY ... LIMIT?
At 5 years you're fully vested. You should get a stock/options refresh if they want you to stay.
I was just thinking that I couldn't decide if it was retro or ... just ugly.

Not that every site has to be super fashionable or anything (I prefer minimal) but that platform bar on the left (scroll down) seems kinda ... icky.
The median student loan debt is inching towards the median starting income for college graduates, something that massively sets people back in their ability to move forward in their life and do things such as purchase a home. Add on to the fact that job growth has concentrated into a few cities that are rapidly becoming more expensive and you have what we have today.

If wage growth matched productivity gains, a lot of these problems would be non issues. Nothing in here has anything to do with entitlement.
Why doesn't the stock market act as a balancing system to low wages? Lowering wages implies higher efficiency thus resulting in higher profits which ultimately end up in "investors" pockets. Why are these "investors" not the common American "worker" whose wages are low? Why has the market not created such an instrument to supplement the "worker" who has low wages but could ultimately profit from the ever-increasingly efficient economy?

This is an honest question whose answer I ponder. Why doesn't the stock market act as a great redistributor of capitalistic wealth?
Same here. I would rather die than share with dirty poor people.
Isn't this just a variant of taint analysis?
It's then interesting to compare to C#, which also can do stack allocation, but still chooses a generational GC.
How exactly would blockchain do anything that a regular database couldn't do in this instance?
> The write barriers you need reduce throughput, but they're ordinarily counterbalanced by the throughput gains you get from bump allocation.

Bump allocation significantly increases throughput only if you allocate a lot. If you don't, maybe you gain more by avoiding write barriers. And, as explained in the article, Go tends to allocate less because it is value-oriented (instead of reference-oriented, where most values are "boxed") and thanks to escape analysis.
They don't use electron, but chromium embedded framework
I vividly recall getting a visit (around '96) from Mark Shuttleworth (of Canonical fame). He had founded Thawte Consulting, I think the first competitor of Verisign, who were the only company that sold SSL certificates at the time.
He was traveling Europe to visit ISPs trying to woo them into using his service for SSL certificates.
He had to spend some time explaining what certificates actually are, because I only had a vague idea (I founded one of the first ISPs in the Netherlands but nobody used SSL at the time).
He was much cheaper than Verisign, by automating the process on his site so it was an easy sell.
Do you know if process information contains command-line information? Because that could totally contain someone's credentials...
This is a very bad analogy, and you have misunderstood the problem to a huge degree.
I was wondering the same thing, but if they can get their brand name established ... might help.

Also maybe you can sell out to the big guys.
> Also a plan in the $5 range would be greatly preferred. My threshold for moderately helpful services is usually $5/Mo.

Very much this. I was using Dropbox, and the 2 gig free plan wasn't enough, but I sure as hell didn't need a whopping 1 TB, so I switched to Google Drive. The 15 gig free plan is enough for me, and I can rest easy knowing that if I end up needing only a little more, I can get 100 gig for $2.

That said, I definitely preferred Dropbox's client more. Google Drive for some reason is frequently showing an X on it's sync folder indicating it isn't syncing even though it's working fine. Google Drive's client also seems to be really slow to start.
Are you saying I could take a tablespoon of oil after a donut and it will change the glycemic load?

I have been taking a cup of Metamucil after I have a dessert with that same theory in mind. Maybe it’s been helping.
It isn't particularly reasonable, one might even say dismissive, to suggest that someone explains themselves, off site no less, when you aren't adding much to the discussion yourself. Plenty of people have already written about these comments. Most widely after Mike Mortiz made similar ones in the Financial Times.

https://venturebeat.com/2018/02/11/what-sequoias-mike-moritz...
https://techcrunch.com/2018/01/19/moritz-sabotages-sequoia-a...
https://twitter.com/dhh/status/954319522151976960
https://gizmodo.com/sam-altman-is-an-idiot-1821327260
https://www.bloomberg.com/view/articles/2017-12-15/appraisal...
There is a concept in insurance called "shirking," which is the principle of externalizing as much risk as possible.
> There was a way to compile D to WASM before (using the dscripten package), however that was more akin to a collection of loose pieces strung together.

Also carried the large Emcripten runtime. Sure it gives you a lot of things like posix impls, but the unknown triple is very lightweight (at the cost of sys/OS abstractions of course).
I sincerely appreciate this reply. Not enough people are willing to do to what you just did.

I agree with everything else you said here. More money is always going to be the quickest and simplest fix for this. I was simply pointing out that financial education should also be part of an ideal solution and that education alone is "better than nothing."
As the game developer, I do not care if anyone else agrees to it. I am the ultimate authority. Thus, I don't need any kind of blockchain.
While I applaud cynical views in general, since most of the rest of the world has restrictions on the prices of prescription drugs this idea doesn't work in most cases.

There is a more cynical view, and you should definitely take it. Less doctor involvement means more people taking prescription drugs (the pharma companies hope).

As an aside, I cannot tell you how angry our direct-to-consumer drug advertisements make me. Especially the ones that are marketed to people with terminal diseases offering them hope (but in the small print offering perhaps 3 months longer life, not guaranteed).

Everyone involved in the process should be ashamed of themselves.
Interesting, thank you. So a potential mitigation strategy could look like this:

- Route 53 failover record
* primary record: Google global load balancer IP
* secondary record: Route 53 Geolocation set (really need that latency)
- Elastic Load balancer record per region
* routes to mirror region GCP IP address (ELB's application load balancer seems to able to point to AWS external IPs)
* optionally spin up mirror infrastructure in AWS

Seems brittle. Does Azure support global load balancing with external IPs?

Does anyone have such (or similar) setup actually in production? How did it work today?
There are other ways to thwart those automated attacks.
Why, what does it do on mobile? Block line reflow?
> Am I the only one who thinks that their design is basically same as any other Saas company

Stripe is almost 10 years old. If their design looks like other SaaS companies or Material or Bootstrap or whatever it's most likely because it has been imitated or at least influenced other designers.
The statements "There exist valid and rewarding career paths for those who are willing and able" and "There exists a troubling economic trend between the relationship of capital vs labor that should be addressed" are not contradictory statements - both can be true.

People should have a sense of personal responsibility, certainly. People should also be financially educated and make good career decisions. We should also look to our political and financial organizations to find problems in the large and do what we can to fix them. And since we live in such a diverse society with drastically different values (the very values your daughter and her colleagues nobly fight to protect), the answer is not "everyone else should adopt my way of thinking". Even if you're "right", that is simply not a realistic path for policy makers, who need to deal with problems in the large.

Maybe this will highlight my thinking - I'm an engineer who went to engineering school and chose a rational career path with high expected gains. I have friends who majored in art at a very expensive school and will likely never be able to pay off their debts. I would say they did not manage their career well and perhaps should have made a different decision. However I would not want to live in a world where we did not have artists. Art education of some type is necessary for us to maintain our culture, so if everybody did the personally "rational" thing where would we be as a society?
I agree with this. Every offer I've gotten from an early-stage startup was market salary and <1% equity, often when I was engineering hire 1-5. I had conversations with founders and told them that if they couldn't meet my market rate, they had to give me 3-5% of the company. They all said no, so I did to. Then I'd get my market rate from a bank or a security company or went back to contracting for multiple clients.
For the record: I run RouterOS in ESXi on a Supermicro SYS-5018D-FN8T (1U, Xeon D1518).

Mikrotik hardware suffers the same problems as Ubiquiti (and most other manufacturers): it's very easy to lose gigabit routing performance with even the most basic of home firewall rulesets.
As a college student I work taking phone calls for a biz that attends entirely US customer base, my colleague asked why our clients were often leery about sharing things like their photo ID with us, despite being customers with us for many years.

As one of the few who lived in the US amongst us I'd have to say it might have to do with how much companies involved in risk assessment really know about you and how much of it goes to the government -- they have no interest in having us show up in their credit or what have you.
You realize that's why the FDA introduced the "behind the counter" classification, that requires pharmacist interaction - and frankly, I trust my pharmacist on drug combinations more than my physician.
Something like this, but I wouldn't want to deter non-engineers from playing or feeling inferior to engineers. I still want to believe that fairness can be enforced and different skills and strategies can be competitive, not restricted.

It is unfortunate a negative perception for cheats is so universal some countries are insane enough to make it into their laws. Call me names but I perceive computer game[1] cheating as something that surely has a positive part. A lot of games are all about exploiting their mechanics (also called "developing a strategy" or "looking for weaknesses") to... err... win (or not lose). Cheats are the engineering solution to this, sometimes dull and non-imaginative, sometimes beautifully cunning hacks.

That is, unless we're talking about cheating griefers which I feel must be considered as a separate kind of people. Trying to gain advantage is natural for any player, depriving others of their fun is not[2]. If cheating makes grief (besides envy!) to other players I believe it means that it's the game mechanics that are flawed for allowing this. At least it's treated as a bug in all other kinds of software engineering.

Of course I recognize network lag is the enemy and computational complexity is another, so at least for anything fast-paced developers just have to offload calculations onto endpoints, sure. But still...

Oh, and I think this should be certainly possible for games where players don't compete. It's not impossible to believe a game where you can cheat yourself into gaining all the treasures of the world but that wouldn't mean anything and cheater would just deprive themselves of the fun. At the very least, the trend to try to shove anti-cheats into single-player games disgust me.

_____

[1] I'm not sure about other areas of cheating. Although I think I wouldn't mind seeing Cheaters' Olympic Games, allowing humans with any aids, robots and basically anything that is physically able to participate. That would be fun and probably awe-inspiring to see.

[2] Can we talk about cheaters' moral codex, haha? Do unto yourself only as you would have others do unto themselves too and stuff.
> The chance that you get an accident with your car is significantly higher

There's a difference between fatalities and accidents. Fatalities are surprisingly low. Plus, Air travel is only significantly safer per-km, per-journey it's not at all safer [1].

> Its just a matter of impact.

Poor choice of words.

[1]: https://en.wikipedia.org/wiki/Aviation_safety#Transport_comp...
After I nailed U+1F680 U+2604 U+1F4A3 = Armageddon, I left feeling empowered.
Mandalay Bay owner files complaint against victims of Las Vegas shooting
Appreciate the feedback - been trying to make that look better and I agree it's not the prettiest. Any ideas?
Hope to see a book by brandur there someday.
Two years ago, I bought a ASUS ZENBOOK UX305FA and it is fanless and works well under Linux. Maybe there is some newer similar model.
Primitive Technology: Wood Ash Cement
Dutch company receives funding for lab-grown meat in restaurants by 2021
I don't think unknown unknowns are what I'm thinking of here. In this case the argument involves a very specific risk, and sometimes a very specific lower bound for its probability.

For example, in the hash collision case the argument says that it's not worth worrying about the (known) probability of a software error due to an unexpected hash collision because it's dominated by the (known) probability of a comparable error due to cosmic radiation. (The former probability can be calculated using the birthday paradox formula, and the latter has been characterized experimentally in different kinds of semiconductor chips.)

This kind of argument doesn't rely on the idea that there are other risks that we can't identify or quantify. It's about comparing two failure modes that we did think of, in order to argue that one of them is acceptable or at least not worth further attempts to mitigate.
That should be defined in /etc/services.

~  grep ssh /etc/services
ssh	22/tcp	# SSH Remote Login Protocol

And /etc/nsswitch.conf is configured to look at 'files' to see which ports map to which services.
> to the places where desperate poverty allows wages to be as low as possible, and the greatest degree of worker exploitation is allowed.

Not that it helps people today, but eventually this trend leads to reductions in poverty and their children demand more. Look at China's middle class. I don't doubt that in 50 yrs they'll be equally as entitled as American and European labor.

So I agree this is a hard time, but I think it's the result of non-smooth changes in protectionism and the ability to globalize the workforce.
AFAIK for card not present transactions, if a chargeback occurs, the merchant pays for the refund, plus a chargeback fee of ~$25. So unless the credit card victims are particularly clueless, this shouldn't be profitable for the merchant.
This is third degree price discrimination by Dell. I should have been more precise in my first comment.

To be crystal clear: the 9360 has a bios featuring the proper ACPI tables, which are omitted on purpose from other cheaper models, breaking S3 on purpose.

This is why injecting proper tables as proposed in this link restores normal functionality. It is not rocket science, just hard enough to do without proper documentation to be a waste of time.

The initial submission title said it was a shame, and I agree it is shameful to intentionally break features to charge higher price (and no, I won't buy that S0 works perfectly now, or that adding a simple if/else is "too complicated"
Here is a map of the world marking the endorheic basins:

https://en.wikipedia.org/wiki/Endorheic_basin#/media/File:Oc...

Everything in gray is an area where simply following the current gradient of the land downwards will not lead you to the ocean. As you can see, this is a sizable chunk of the world.
There doesn't seem to be a youtuber by that name - unless he deleted his account or his videos.
CONVERT CRYPTOCURRENCIES TO FIAT CALCULATOR