skysight-inc/HackerNews huggingface dataset:
It is worth noting that these SNPs aren't causal, they are just associated.

The resolution of GWAS isn't at the level yet where we can pick out individual changes that cause a phenotype. Instead we can detect that a chunk of the genome is associated with a phenotype. These snps are like a street name, they identify the region associated.

We need whole-genome sequence on a million-person scale to actually find the causal variant. That will come with time.
1. Playing World of Warcraft all day, every day.

2. Stop.
Just copy-pasting the same message here multiple times doesn't make it any more true.
Yes. Almost the entirety of engine wear occurs when the oil temp is too cold. By turning on the vehicle and immediately driving (conservatively below 2k rpms) you greatly reduce the amount of time it takes to warm up your engine oil versus when left idling at 500rpms. I learned this from reading the manual to my BMW and Subaru.

In -20 degree weather you won't accomplish much idling and should purchase an engine block heater if concerned.

Interesting article confirming what I am saying:

https://www.washingtonpost.com/news/wonk/wp/2014/12/29/the-b...
The particular videos are designed by this approach (GANs), and thus the generator is highly adapted to generate data that can't be distinguished from a real video with these techniques.

If it's built with state-of-art GANs, then you don't be able to reliably detect it with discriminators from these state-of-art GANs. If you manage to build a better automatic discriminator than the authors did, then they could directly use it in the adversarial approach to build a better generator, and your detection approach would again cease functioning.

Remember that in the end there's a fundamental asymmetry - in theory, there could be a perfect generator (not that we're close to perfect yet) that generates undistinguishable samples, and thus there can not be a perfect discriminator.
If you have a severe loss in income, bankruptcy after 2 years is probably too late. She probably cleaned out her retirement funds, which used to be largely protected from bankruptcy.
Just because she looked important at work, doesn't mean she was compensated as much as you all seem to believe.
The (simulated) fly brain would signal muscles to contract for flight. How would we simulate the muscles? Wings?
Go out more, meet more people, take more chances. Your social life will likely never be as lively as it is now, especially if you build a family at some point. Try different things. If you don't like your job, quit; your best moments always come when you overcome laziness enough to throw yourself into deep waters.
uses nicotine product

"I didn't know this nicotine product had nicotine in it, I'm suing!"
Food Additives Causing Harm, Reforms Urgently Needed, AAP Says
The Awful German Language by Mark Twain (bad Language Design)
U.S. Department of Defense Established a Center to Better Integrate AI
Here's the 3rd edition of the Venture Deals book https://www.amazon.com/Venture-Deals-Smarter-Lawyer-Capitali...
Credit scores increase
i was about to apply for a mortgage loan before i discover my credit score was 575 and i couldn't get the approve for the
mortgage loan at that moment because of my low credit score. My old friend of mine introduced me to this genius hacker, I
get in touch with him for help and to my surprise, He increase my credit to 835 excellent and delete all negatives
collections on my report. He helped me delete all negatives items on my report, I got approved for mortgage loan. He's the
best when it comes to credit score, His services are cheap and affordable. Contact him for your credit fix
Databasehackerservices At Gmail Dot Com
I had just moved to Ann Arbor and started at Arbor Networks after the failure of the first company I founded. My son was 2 years old and my daughter had just been born.

I'd have done a much better job handling my personal relationships.

Nothing I did at age 25 had really any material impact on my career. I liked A2 and the people I worked with at Arbor but I can sum the career value up as "can occasionally write an authoritative-sounding comment on HN about ISP backbone networks or DDoS attacks".

The relationship stuff though, that stuff stuck. It is kind of a miracle my marriage survived 25-year-old me. Lots of my friendships didn't survive.
Cloud computing is the big one. You might want to rent some remote computer time without sending plaintext data to a third party. Homomorphic encryption lets you upload encrypted data and instructions for a third party to operate on it without having to decrypt it first.

Edit: Try Greg Egan's book Permutation City.
Hmm, that's just not true at all. Don't leave your pups in the car. They won't be comfortable, they'll be dead.
I don't mind you being blunt at all, but do you mind naming those schools specifically? I'm still skeptical.
I was working at a coupon code website in Austin, Texas. I don't have any good professional advice for me back then. I'm pretty sure I did all the right stuff. I had a company fly me out to the Bay Area for a job interview, and then snuck some time during that visit to interview with another company for a job with a better title and salary, a relocation bonus, and a less despicable vertical (the other one was in "debt relief").

It wasn't a great job, but I stuck it out until I didn't have to pay back the relocation bonus, and then enjoyed a couple of amazing jobs in SF before having my fill of the Bay Area.
Moved to London, started several side projects, joined a startup that was actually paying very well and was doing an interesting technology.

What would I change? Probably nothing, but I would want to change what I was doing at ~21, where computer games were dominating my spare time, I wish I started working on side projects early on. Nowadays I find building things more rewarding.
Working on megayachts as a deck officer spending summers in the Med and winters in the Caribbean. Eleven years later I'm a lawyer working in house.
Intro to NLP: TF-IDF in Python from Scratch
The Peacock in Menlo Park: On Open Offices and Signaling Theory
Given the convenience of overnight charging, it does seem like manufacturers could come up with a solution that improves the outcomes. Then again, they sell batteries, or new phones...
Not so fast. For years, Google has supported channel binding between GFEs and Chrome. The cookie alone is not enough: you need to steal the private key as well. I can't remember if that's the case, but it would make sense for @google.com accounts to have more aggressive settings.

http://www.browserauth.net/channel-bound-cookies

Even before that, Google has had a system to detect cloned or tampered cookies on the server side for more than a decade, as described in its patented glory (don't open if you think your company's lawyercats are going to be unhappy):

https://patents.google.com/patent/US8302169B1
Yes, what ever the cause of loss of sleep the effects are the same. You need to sleep for lots of brain and body maintenance.
People take search engines for granted today, but that's what really changed the internet into something useful. That and learning that you can sell user's metadata for tons of $$$$. Those were really the two innovations that this author (and most people at the time) didn't see coming.
Coin-Operated Capitalism: legal analysis of ICOs
How does this affect internet searches?
You did right by your customers, you made a solid product and you’re not hurting anyone with your business.

Better just to ignore the religious radicals sneering on the sidelines.
It's incredible how the system progressed over the years. I wish they will be able to get funding to continue.
Literate Visualization: Theory, software and examples
> (the graduates I've been interviewing in SF) ... can't practically design a system on their own, and if ever confronted with a graph theory problem, can't do much more than name-drop algorithms, and fall far short of being able to implement those algorithms.

Interviewing people does not tell you the capabilities of people - interviews are very artificial processes.

I'm not exactly a computer scientist (or a recent graduate), but I work with tradeoffs every day, most of which are data derived, not problem derived & that is only visible from experiments on the data (sometimes across millions of ops).

However, what I really end up doing is actually different from just running experiments - I run the scale tests and go running while it runs.

I do my best thinking when I'm running - about a 10 minute mile pace in sunshine gives me my best ideas, perhaps it is a heart-rate thing.

And even when I have an idea, I will dig through researchgate for a couple of hours before I actually start pulling it apart (often, I find people have described the math which helps me think better) - like HyperLogLog used for IN() estimations.

Nobody's going to allow me to do any of those things in an interview.

Interviews are really about selecting people to hire, not about their abilities.
I worked on software for all of the major US cigarette manufacturers.

These companies are very interested in pushing their own lines of packaged/disposable e-cigs. It is very different from the cottage style hobbyist/enthusiast e-cigs. The big companies are kind of blind to this segment of the market, I don't think they truly realize how large it is.

Their approach will be to have the e-cig industry regulated much like the current cigarette industry is... in such a way that they can win through the sheer scale of legal attrition and achieve the current prices they have in cigarettes.

It is not by mistake that there are maybe 3-4 meaningfully large cigarette companies in the US that set the prices and rules, it is impossible to enter the industry.

I think there will always be an enthusiast segment of the e-cig market, much like the pipe tobacco one that exists now. Pipe has many small manufacturers and far less legal hoops and administrative overhead.
Suffering from untreated anxiety/panic disorder, still working on finishing a BS. I would gently and firmly tell my former self to take a break, get some help, and return to school when I was better.

And more generally, to anyone struggling against personal problems (mental illness, substance abuse, family issues, etc.) while trying to achieve a career goal: at some threshold of severity, it's a better use of your time to focus on fixing those issues, and only _then_ returning the focus to career. Not to mention that it will save you some suffering.

Luckily for me, things eventually worked out, but I wasted several years trying to ride two horses at once.
Introductory video - https://www.youtube.com/watch?v=K-yoLxnm95A&index=7&list=PL-...
From the FAQ:

> The current study further confirmed the finding from our earlier work that the effects of individual genetic variants on educational attainment are extremely small. The average effect size across the 1,271 genetic variants was just 1.8 weeks of schooling per allele; even the SNPs with the strongest associations only predicted around 3 weeks of additional schooling per allele. Taken together, these 1,271 SNPs accounted for just 3.9% of the variation across individuals in years of education completed.
​
> Here is another way to think about this result. Imagine that we used the results for these 1,271 genetic variants (not the ~1 million SNPs across entire genome we discuss in FAQ 2.3) to predict the educational attainment for a new group of people (separate from our discovery sample). We could then compare each individual’s predicted educational attainment to their actual educational attainment. If we did so, our results suggest that we would find that the predictions and actual outcomes correlate only very modestly (at about r = 0.20). That, in turn, means that if someone were predicted to complete an above average number of years of schooling (i.e., to be in the top half of educational attainment), that person would have about a 58% chance of actually being in the top half of educational attainment. Fifty-eight percent is better than chance (i.e., 50%), suggesting that a prediction based on these 1,271 SNPs has more power to predict educational attainment than a coin flip—but only a bit more power. By contrast, a prediction based on a polygenic score that combines ~1 million SNPs that we studied (see FAQs 1.5 & 2.3) has more predictive power: r = 0.33, corresponding to 11% of the variation across individuals.
​
> The contrast between the 3.9% of the variation predicted by the 1,271 SNPs and the 20% known to be explained by common SNPs (see FAQ 1.7) implies that there are many other SNPs that have not yet been identified. Even larger sample sizes will be needed to identify them.

They only included people of European ancestry to eliminate sources of noise and cofounding factors. The effect size is very small, yet it does exist.

This seems to prove that intelligence influenced by genetics but is affected by many thousands of genetic variations. There is no "smart" gene, just lots and lots of randomness.
Everything on your private registry requires a CentOS base image? What about public images? If you wanted to run elasticsearch or nginx, would your company policy be to build a custom nginx or elasticsearch container image?
There are two approaches worth considering.

Evaporative cooling is not worth doing in Boston for the space in a residence. It can be used, however, to improve the efficiency of refrigerated air units. Take a look at air conditioner misters that spray hose water onto the radiators for refrigerated air units. Although I suspect a good percentage of that heat is carried away simply by conduction rather than evaporation, it could conceivably cut your air conditioner bills. Water-cooled whole-house air conditioners are high maintenance, otherwise they'd be commonplace.

The other approaches involve tag-teaming a refrigerated air unit with a swamp cooler. The air intake for a refrigerated air system would work a lot better at 80 degrees, 80% humidity than 90 degrees, 60% humidity. I am told this is commonplace in Phoenix.

One other often-overlooked characteristic of the "swamp cooler zone" is that it tends to be at high altitudes, which aside from keeping things dry and cool enough to have a shot at good-enough cooling, requires doubling the size of refrigerated air units to keep pace with design specs. The air is thinner enough up here that the radiator can't keep up as well. This shifts the balance slightly in the direction of swamp. This has been what feels like an unusually hot and humid summer in Albuquerque, and our household finally sprung for a room air conditioner, run in parallel with the swamp.
When you emulate NES games, you don't emulate all of the atoms in the NES processor, you just go with instruction set and write down some simple aproximation.

You would do the same in biology.

c elegans connectome has about 300 neurons. If you would simulate the neurons on a hardware level it would be enormously complex task, you would have to deal with ion channels and quirky stochastic effects, perhaps even some quantum physics simulation.

The brain of c elegans is insanely complex. The brain structure, on the other hand, is ridiculously simple.

You can just take connection and activation weights and write a simple neural network equivalent in an evening. And it would work about as good as a hardware simulation.
2 years is a lot of rainy days.
If the memory usage can increase 10x while this is not reflected in the assumptions, both the measurements and the assumptions are flawed

To give more context: I run many copies of a daemon with known memory leaks, on machines each with a load close to 0.7 and about 200M of free ram left. I consider that an heavy load.

This approach restarts one of the copies of the daemon when its own leaks become dangerous to the rest of the system.

It is not perfect, but good enough when the numbers are measured at peak. The 200Mb free RAM are all the extra leeway I care to leave.
I can confirm.

My team at Amazon was a customer of AWS just like every other team at Amazon is. Every department/subsidiary at Amazon charges one another for services provided. We all operated as cost/profit centers.

In fact, as far as Amazon policies go, this may be the only one that actually satisfies every Leadership Principle [0].

[0] https://www.amazon.jobs/principles
Dreaming is how memories and skills are encoded in the brain. The second half of the night is more likely to involve encoding of physical skills like sports. Also more prone to nightmares.
(I'm 28.)

I'd tell myself to focus a bit more on finishing up my PhD than following dead ends. That and go outside more and eat better. It took ~2-2.5 years after graduating to regain sanity and lose ~50 pounds.

And I'm pretty happy with my current job.

Generally, I'd say that's advice I'm going to try to stick to (whether it's a job, PhD, whatever): focus more, go outside more, and maybe eat some vegetables every once in a while.
Yeah that's the gist of it. There are things like adaptive control where aspects of the model are adjusted on the fly in real-time to improve performance based on data from the system and robust control that tries to account for modeling error.
[event] Due Diligence: Digging in with the Investors with Terri Mead
I'm at an American university, and while technically this is true, an advisor going to the committee and saying "I want this person and I have the grant funding to support them" is profoundly influential, to the point that I would be shocked if the committee said no.
What's Actually in a Frozen Pizza
This is Julia, the OC. You're totally right that we didn't realize how hard raising money actually is. A lot of other founders I've met also don't realize, which means they're disappointed and discouraged when they try. The point of this post is to encourage founders to keep going even when they're down. I almost stopped fundraising a month in because I was so down, and now I'm grateful that I didn't.

Everyone has imposture syndrome when raising. I wrote this post to let founders know they're not alone and to not lose their self-confidence because of investor rejections.
Being in crypto, fortunately I won't have to.

One of the few benefits of ICO: you can now raise money without having to bother with VCs. That's a nice evolution.
Firefox has implemented it, although you need to go to about:config and enable "security.webauth.u2f" for it to work.
I left the UK for Spain whilst working remotely. Best decision I ever made, wouldn't change a thing!

You have to take risks if you want to lead an interesting life. 25 is the perfect age to do some "crazy" things like moving to another country.
At 25 I was completing my sophomore year in college. This was because my father decided to stop filing his taxes for the 10 years (1995-2005) that my sister and I would have gone to college, so we had no ability to even apply for college loans. Her and I have no idea why he did that, and I'm not sure how to ask him today.

So I worked at Safeway until I could start paying for college at 23, then could file as an independent student at 24 and started getting financial aid.

The advice I'd give myself is to go back to when I was 15, when this all started, and file my parents taxes for them.
The cigarette companies know that we're going down the path of higher prices, higher taxes, more restrictions on sales and advertising, and more restrictions on places where you can legaly smoke.

That doesn't make them scared of the vape business, it makes them want to join the vape business, and a number of them already are selling ecigarettes and juice.
The third-party repair industry exists because companies can profitably undercut Apple's out-of-warranty repair charges. That's true in the US and it's doubly true in lower-wage economies.

It may be that skilled repair work isn't scaleable, so Apple have decided to constrain their repair operations to simple module swaps. It may also be that Apple would rather sell you a new device than fix your old one, so have taken an approach that is broadly hostile to repair. I suspect it's a bit of both.
If the windows are open then there's no greenhouse effect going on, so it wouldn't be any worse than if you were walking them. Air conditioning is still a lot better.
If you think simply appending "Too" to the end of Black Lives Matters would fix anything, then you don't really understand the problem. There is a reason why some segment of the population instinctually read BLM as "Only Black Lives Matter", instead of "Black Lives Also Matter".
At least Hollywood has tabloids to keep things reasonable!
Automating My Newsletter Generation with MailChimp, Google Sheets and AWS Lambda
It was 2009, and I was working odd jobs to support myself while trying to be an artist. I was incredibly depressed at the time. I had graduated with a fine arts degree in 2008, and the recession made it extremely difficult to find even normal work, much less anything arts-related.

The best advice I would have for myself, both then and now, is to work smarter, not harder.
Noise: Fischer Black (1986)
I'm 28 now and I switched jobs 3 times at the age of 25, got my first serious girlfriend, moved out of my parents apartment.

Back then it felt like everything happens super fast, three years down way more things happen even faster.

Could I give a 25-year-old some short-sighted advice? Probably, but 25-year-old me wouldn't listen, I've always believed everyone is different so you can't really just hand advice like it's a life manual, things eventually happen to you. I think(much like others in this thread) that most things you do at that age will probably not impact your life as much as you might think.
Motivations for Use Have Transmogrified
That is not true. In western countries one must smile to be polite, even if the smile doesn't represent his/her current mood. There is no objective reason to render happines in common situation for Russian people.

One may smile when he meets a friend or sees some cute kitten, but in general people are walking in some meditation alike state, thinking about the current affairs and not particularly paying attention to the people they passing by.

And when russian person meets the grinning stranger with cold eyes (not his real mood). It looks kind of creepy. Ordinary people usually do not pay much attention for this kind of encounters. Police (are you drunk?) and street scammers(are you a tourist?) - do.
"American justice system is the worst possible justice system, with the exception of all of the world's other justice systems"

That's a reworking of a quote attributed to Winston Churchill : "Democracy is the worst form of government, except for all the others". Not a sentiment typically attributed to the US justice system.

As a justice system, the US is one of several with roots in English common law, and has its variant strengths and weaknesses compared to the others.
How to Become a Millionaire