skysight-inc/HackerNews huggingface dataset:
I agree to most of the things the author said (except for America being the center of the world and a moral lighthouse for everyone of course). But what I think will get overlooked by most people is the beginning where he notes that the chinese he has met in his daily life are very nice people. Do not forget that they are the same as you. It sounds obvious but I think most people don’t realize how similar we all are. Probably every deeper concern you have had a chinese and russian and american person have also had. No they do not live worried lives where they think that if they break an arm they will be bankrupt. No they are not afraid every day of government agents knocking on their door to drag their father away. The risk of each one is larger in one country than the other. But day to day people think about the same things. Every country have their introverts and extroverts, engineering types and warm hearted caring types and the discussions that one does not exclude the other. Superficially chinese cut in line because if you dont cut you get cut and i am sure you would do the same if the situation was the same for you. Unless you are the quiet introverted type, which is also the case in China. Dont forget that this person talks about governments. You should dislike Xi for what he does to the chinese people, not for what effects you fear he may have on USA (the government, not the people).
Here is what I am responding to (also keep in mind I was using indel to mean "indels and substitutions", ie whatever may be counted as an error during NHEJ):

> "There's no way cells survive with indels at 10% of their base positions, that's not possible."

> "How is the per-base indel rate not 10% if 10% of cells carry an indel at any given locus?"

I figured you were referring to per base within each cell. Your overall "per base" rate is getting the average (across cells) number of mutated sites. The survival of a cell is determined by its own genome, not the average of the population its been grouped into.

However, it is the case that if x% of cells have a mutation at any given site then there must be at least some cells in this group that contain x% or greater mutated sites. Is that what you meant? Because that's not a bad point. I don't know where that 10% value came from and have no attachment to it, just assume that one is measurement noise for now, but even cells with 0.1% of sites mutated seems like a lot.

There doesn't seem to be many whole genome single cell sequencing results available yet, which is what I think is needed here. Here is one that reports ~ 15k SNVs, 50-100 "micro-CNVs" (ie 10-100 kb copy number variants, fig S4), and 290 indels:

>"We call an SNV if there is a called NR allele and: (a) the total read depth in the bulk sample is above 15; (b) no bulk read has the NR allele; (c) if two SNVs are within 100bp from each other, both are discarded. With this procedure, we called 15,940 SNVs on the autosome of sample BJ1...We called 294 putative INDELs from the BJ1-BJ2 pair, the negative control"
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538131/

So taking the smallest and biggest numbers of possible here gives:

100%*(15e3 + 50*10e3 + 290*1)/3e9 = 0.02% of bases affected
100%*(15e3 + 100*100e3 + 290*10e3)/3e9 = 0.4% of bases affected

This seems to ignore any very small or large mutations that may affect a given site, and not all the mutations will simulate the effect of NHEJ... but this makes me think it isnt impossible for 0.001-1% to happen, especially in vitro.
The economic historian in this interview has interesting things to say:

https://www.washingtonpost.com/news/wonk/wp/2016/10/28/why-t...

China and Europe are different in many ways, but one is that after the Mongol conquest in the 12th century, China remains a unified empire run by a single Mandarin bureaucracy. There is nothing that competes with or threatens China. China does get invaded by Manchu tribes in 1644, but they don’t change the structure of the state. They learned to speak Chinese, dress like Chinese and eat like Chinese.

In Europe, no one ever succeeds in unifying it, and you have continuous competition. The French are worried about the English, the English are worried about the Spanish, the Spanish are worried about the Turks. That keeps everybody on their toes, which is something economists immediately recognize as the competitive model. To have progress, you want a system that is competitive, not one that is dominated by a single power.

I think that is the major difference. It isn’t just that China doesn’t have an Industrial Revolution, it doesn’t have a Galileo or a Newton or a Descartes, people who announced that everything people did before them was wrong. That’s hard to do in any society, but it was easier to do in Europe than China. The reason precisely is because Europe was fragmented, and so when somebody says something very novel and radical, if the government decides they are a heretic and threatens to prosecute them, they pack their suitcase and go across the border."

[...]

"I believe the fundamental reason is China’s position as a single empire, and also its bureaucracy, which is a unique and peculiar animal. On the one hand, it is very progressive, because it is a meritocracy. In Europe, the people who were in power were the sons and nephews of other people in power. But in China there’s an examination, and the people who did the best rose in the Mandarin civil service. So you’d think, “Wow, that’s very progressive.” Except if you look at what they were studying for these exams, they were simply regurgitating the classics. It was the perfect tool to keep reproducing from the same mold generation after generation.

In Europe, something different happens. People study classical knowledge, Ptolemy and Hippocrates and Archimedes, and they begin to say, “Most of this stuff is wrong.” You couldn’t do that in China. If you said “This stuff is wrong,” you failed your exam. But in Europe, the ability to challenge received wisdom is irrepressible."
>Calling yourself a "diagnostics" company is a good way to get ignored by VCs. [...] So you have high development cost and low profit potential

What can regulatory agencies do to alleviate this?
L5 is science fiction, nobody has even an hypothesis about how to do that. Zoox and the other major players are developing L4.

There is another interesting, but still young company called Aurora innovation that has a very good team together that plans to develop and licence L4 to 3rd parties. Aurora has partnerships with 2 of the top 3 biggest car manufacturers in the world, VW and Hyundai, as well as with Byton, a Chinese EV startup backed by big Asian capital. Zoox has a different plan.
Indeed. What ever happened to product differentiation?
The docs say 10.11 for most of the APIs. A few are still (and forever?) iOS only.
That's fair. I was mostly reflecting on the time that most bootcamps spend on a student (2-3 months) relative to other programs.

But I agree that no matter the program, security best practices are rarely taught.
I would suggest that despite the country or the company or the culture you are working, you have to lead by example that means first you have to work hard to prove to the team that you are capable to lead them, both technical and leadership.

When you lead by example, you set the standard for code, design patterns, documentation, etc. and as you go along build the tools, infrastructure, processes and culture.

Don't expect to change everything overnight, it will take time, be patience and you have to trust people you will be working with.
Having driven in both countries, I totally agree, with one slight caveat.

In the past, I had the opinion that due to individualism versus collectivism, US drivers tend to take things a lot more personally.

If you accidentally cut someone off or honk at them, US drivers feel it's a direct assault on them. I've witnessed and even personally encountered some scary road rage in the US, but never in China.

However, after finally having the chance to drive in New York, I realize that it's actually a city versus suburban driver/pedestrian culture.

I was quite amazed by how driving in New York City was so similar to driving in a Chinese city. Where it's more of a "dance" between cars, pedestrians, and other vehicles like bikes.
This article supposes that a meteor impact is more likely than disaster that renders northern California (their only data centers are in Oakland and Sacramento AFAIK) without power or civil order within ten million years.

As someone else pointed out, it’s overly simplistic. They’re a great low-cost alternative to S3, sure. But keep a backup on another continent if you need your data 100 years from now.
They can't detect the presence of mutants if hey occur at frequencies at or below the background rates. I mentioned this multiple times. Its simply that no one knows if they are present or not. Earlier:

>"You could call that noise of course, at the very least they can't detect rates below those using current methods."

>"Either that or the methods used to measure this are too noisy to detect mutants that exist at those rates."
https://news.ycombinator.com/item?id=17554902
Show HN: A simple 2D bird made with 83 lines of GLSL
Awesome... Can you please share more stories of that time with us? Maybe write them somewhere ?
It's summer now and as soon as I plug my MacBook Pro 2017 in to charge, it starts throttling itself due to the heat of the charging battery. Same thing happened to the 2012 I had before.

These things just don't have adequate cooling.
What has materially changed is that there no longer are any situations where someone knows the answer instantly. The original puzzle only works because everyone has a non-negative integer and their sum is constrained to a finite number of possibilities. So someone who sees a number larger than the second-highest possible total knows that the value of the total is the highest possibility.

The key to understanding the puzzle is that knowing, knowing they know, knowing they know you know, etc. are increasing strengths of knowledge. You can always remove "knows" from the stack, but you can't easily add them (because how do you know they know?). Passing on a given day is the mechanism that introduces knowledge of infinite depth (because everyone knows they are neither freed nor dead and they all know they know they know ...) Because knowing the answer implies that they don't pass, observing a pass eliminates all possibilities where the answer is known (more precisely, it adds one depth of "knows" to the knowledge that that possibility isn't the case.)
This situation perfectly illustrates how underutilized pharmacists are in the health care system. A few states are passing laws that will allow pharmacists to prescribe certain medications but it’s happening slowly due to the typical pressures of lobbies and insurance companies.
>Labor disputes are handled through state and federal labor relations boards.

...which are toothless, especially in Republican-controlled states.
Since you have them with an onclick, add:

onauxclick="e.preventDefault(); window.location.href = '/stories/brumate';"
What if you could diagnose with an eye scan? http://optinadx.com

Disclaimer: I'm an investor in Optina Diagnostics
Why is DARPA investing in general purpose open source technology? I'd expect the U.S. military to seek competitive advantages, but this tech could be used by China, Russia, and Iran as easily as by the U.S. Perhaps this tech suits the U.S.'s needs better than the needs of its competitors?

DARPA has funded general purpose open source tech previously, but for the reasons above I haven't understood why. I'm glad to have the technology, I just don't grasp their motives.
Yeah. I'm saying there are plenty of companies capable of this particular technical feat given the offline HD mapping + Lidar, so it doesn't justify the amount invested in and valuation of Zoox. This technology was available years ago. If say, they did this with vision only and no HD maps, maybe then I'd be impressed.
I guess the key is that it under-performed vs last model's i7... not that it has thermal issues. I would think most laptops have some level of thermal trade offs.
What drove me crazy at first was that any character can be used as a delimiter. That's very useful, I admit. But it complicates understanding examples found through searching ;)
You need to get the money into the US banking system in a way that doesn't arouse suspicion.
Got my first domain in 1996, and it was indeed $70 from netsol. I had many ideas to pursue and wanted to domain them all, but it was too costly, so I limited to just a couple up back then.
"bastion of quality" maybe 5 years ago but I seem to hear nonstop how cheap these things are churning out in the newer models. Not based on my personal experience (spent a bit of time servicing recent models and they felt like plastic all over) but I guess the ultrabook workhorse product competition has grown.
China is 6000 years old and it had never been anything even remotely resembling a democracy. It’s going to remain a bureaucratic autocracy just as it always has been. And that’s fine, it’s worked very well for the Han.
Revolvers.

Fun fact: one of the bartenders at my old watering hole was playing with the "bar gun", flipping the cylinder closed by flicking his wrist, and shot a round into the wall. Luckily I wasn't there that night because accidental discharges are a beatable offence.
No, if it’s good for refills then that process isn’t even necessary until those refills run out; the pharmacy keeps track of them automatically. What GP is describing is a refill authorization request, which happens when no refills are left. It does require the doctor’s approval, but usually does not require a visit as a matter of course, unless there’s a concern the dosage may need adjusting based on, say, new lab tests.

The above mentioned case of doctors who require a pap smear for birth control is unrelated; it’s a barrier to access to contraceptives, which is motivated not by medical concerns or even greed, but by politics.
Instagram will upgrade two-factor authentication to guard against SIM hacking
I did a quick search, this might not be a bad place to start (it references the primary source, raw data, and file usage: https://commons.wikimedia.org/wiki/File:1_AD_to_2003_AD_Hist...

Wikipedia has a good summary both of the Economic history of China [1] and the Great Divergence [2] (really comes to a head with the collapse of the Qing dynasty). Although devestated by civil war and WW2, IMO China really doesn't descend into complete craziness until the Great Leap Forward and the Cultural Revolution [3] that devastated China economically, socially, and culturally (lost generation, send-down movement, red guards, etc).

[1] https://en.wikipedia.org/wiki/Economic_history_of_China_befo...

[2] https://en.wikipedia.org/wiki/Great_Divergence#China

[3] https://en.wikipedia.org/wiki/Economic_history_of_China_(194...
They can use an okay quality thermal joint compound if it is applied well. My Dell's thermal joint compound looked like someone was trying to make a PBJ sandwich with the stuff. Applied too thickly, and it becomes an insulator. Mac used to have this problem in the past. I repasted my Dell and got 5F reduction at load right away.

The problem with all high end mobile CPU's is that they are given a tiny heatsink and heatpipes which are simply not up to the job. They quickly become heat soaked and the fans are unable to reduce the heat, so the units throttle.
I've lived in both and I definitely prefer walking on Chinese roads.

Most US drivers, except for those in New York, are largely unaware of pedestrians, bikes, and motorcycles. I find it much more dangerous to ride a motorcycle in the US because so many drivers don't expect it and do things like turning right without looking behind them.

However, I do generally prefer driving in the US. The only issue I have is with the police. I'm much more scared of getting pulled over by a cop in the US due to some minor infraction, e.g. having a broke tail light, than I am of Chinese cops.
Opioids would not be part of this change. This is for stuff like high blood pressure, cholesterol, migraines and asthma (according to the article).
At one point when I was considerably younger I started learning 32-bit x86 assembly as my very naive career goal was to become the next Linux Torvalds. I managed to construct a multiboot-compliant 32-bit kernel that could load tasks from a ext2 ramdisk image passed to the bootloader and multitask up to around 64 processes. I figured out how to use the CR3 register and craft page tables, enter into kernel syscalls using software interrupts, handle CPU faults, page faults, double faults etc. It was quite the learning experience until it eventually crumbled under my lack of skill and foresight. In short, I got more or less about as far as most amateur, self-taught, lone OS developers get before losing interest and giving up.

Fast forward a couple of decades, and I found myself reverse engineering CP/M for the Z80 processor in order to create a virtual Z80-based system that ran inside Unreal Engine. I started with Udo Munk's wonderful Z80pack system, adapted a public domain Z80 CPU emulator which was written in C to C++, and did minimal reimplementation of the Z80pack terminal and disk I/O devices. Since the systems were implemented as "actors" in UE4 it's possible to spawn and run quite a few concurrently as long as you limit the CPU speed of each instance somewhat.

The resulting virtual system in UE4 is able to run original CP/M ports of Rogue and Zork (https://i.imgur.com/gnOCp3e.png), various Z80 instruction exercisers (https://i.imgur.com/kwNuq5X.png), a Z80 C compiler and and even Wordstar 4 (https://i.imgur.com/Q6307w3.jpg) and Microsoft BASIC.

Learning assembly can be a lot of fun - it can really teach you quite a bit about systems architecture that you otherwise might not get if you're always programming in high-level languages only.
Streaming services have more money than consumers. Replace 10ms with whatever is possible. At some point, the latency will be lower overall.
>Tons of malvertising comes through Google.

Can you cite that as your previous accusation was already proven to be incorrect.

>When one company owns the whole space, finding just one vulnerability is enormously economically attractive.

Google doesn't own the whole space.
That line to me is repulsive in the most literal sense. I don't want to hang out with him when I hear it. Rudeness is repulsive
I’d say that not even being able to maintain the advertised base clock is a pretty key issue. Being slower than last year’s model just adds insult to injury.
If I worked there I would feel the urge to urgently find a like minded employee to talk to just so I'd feel better knowing that someone else thought it was absurd.
Apple it seems is happy to be known for iPhones and iPads but for many people Apple is really about a rich history in computing, computers, good engineering, design and well built products.

Now especially with the mac business they are reducing the scope and value of their brand, and becoming purveyors of high value trinkets. This is nothing short of a tragedy.

There is a difference between a small premium for good engineering, components choice and design, and profiteering to the point of becoming an extremely overpriced luxury product with more brand than real value.
Zoox is differentiated. They're the only autonomous vehicle outfit thinking about a self driving car as a robot from the ground up, rather than just a car with some sensors slapped on to it and a giant computer in the trunk.
That's right. You pay tax in your jurisdiction.

Also you can put your cloud instances in US zones and have US contractors. That's irrelevant to your tax situation.
I should write up a blog post. When I do, I'll submit it here.
I think the whole narrative with Elon Musk and the cave rescue shows not only of his flaws, but also the others who reacted with vitriol on the Internet. It seems like there is a widespread view about the futility of technology, that technology will no longer save us and will inevitably lead to our downfall. (This pessimistic view is reinforced by the recent uprising about Cambridge Analytica, Russia and Facebook Ads, etc.) For those with an extreme version of this view, Elon Musk is regarded as the ultimate villain, the maniac who thinks that technology will automatically solve all of our problems, an impostor trying to pretend saving people with technology but in the inside only a greedy billionaire trying to maximize his profits.

But the world is obviously more complicated than that; when used wisely, technology can figure out some of our problems, when used wisely and depending on the situation. Although Elon Musk’s submarine isn’t a perfect example of a good use of technology, I think some people have reacted without thinking more about it. (Personally I am torn, because if lives are at stake, it might not be a good idea to use a 1-week old engineering design, but then if the “old” method wasn’t successful and resulted in more deaths things might have been different)
Or an overzealous prosecutor.
I worked at an isp that was the state registrar. I had number.street.city.state.us

I should have maintained that.
But does the i9 version have performance issues (i.e. it under performs compared to the i7)? The XPS 15 with the i9 configuration comes with 32GB ram and it much cheaper than an equivalent macbook pro. I can deal with it getting hot!
The rulemakers can make any internal rules they want, including retroactive exemption. However, they are subject to external rules, including law and regulations, and I imagine that the current rules would give a lot of ammo to anyone who wanted to sue TI even if the rules were retroactively changed: The company might have a hard time convincing a judge that conduct that they thought was harmful in February is suddenly ok in May.

> Changing it requires disclosure of the changes ahead of time

Why must they disclose changes ahead of time? Why couldn't they say 10 minutes from now, 'the former policy is now void'?
Scalability Design with MicroServices
IANABiologist, but my understanding is that they don’t differentiate; they have too simplistic a structure for that, and rely on the host cells for many of their functions. The main differences seen across cell types is whether they are present or not.
Maybe you've never had the pleasure, or it's different in other cultures, but having experienced plenty of it first hand, it's incredibly off-putting when people point/stare/or talk about you, especially if they do so in front of your face because they think you can't understand their language.
To be fair they’ve always been bumping up against this since they don’t like to put tons of fans in their laptops.

While this obviously shouldn’t happen, it seems like something you could easily predict might be a flaw if you knew that one had to exist.
No. If someone isn't good enough to find a mate, I don't want their genetics in the next generation.

Evolution made us the best species in the history of the galaxy. Let's not fuck it up now because some loser can't get laid.
I often work outdoors, and merely being in sunlight makes my 13” MBP go to max fan speed after about ten minutes, and insufferably slow after a half hour or so.
You are right, NVIDIA replaced the die for many OEMs, at the time my Vaio was affected and out of warranty, but Sony was nice enough to replace the motherboard for me and the laptop still works..roughly 10 years later..
Kel-Tec P-32?
You forgot the Japanese occupation and exploitation, though I guess you could roll that into the collapse of the monarchy.
I run unbound on my own workstations. It's so lightweight, you'd never even notice it, but it definitely makes browsing a little more snappy.