skysight-inc/HackerNews huggingface dataset:
I think this is an unfair characterization, there are some REALLY good programmers, some new programmers, and people at all stages of their programming journey.

A lot are doing game programming, I'm less interested in this, but some are very interesting. For instance...

https://www.twitch.tv/jessicamak

Really interesting what she does, and an insane attention to detail.

A HNer I watch when he codes... he does an interesting mix of stuff and has 30+ years of experience

https://www.twitch.tv/nybblesio

there's people coding games with robotic bananas

https://www.twitch.tv/uselessduckcompany/videos/all

.NET devs

https://www.twitch.tv/csharpfritz

who also has coding streams with Microsoft Devs

and numerous others doing embedded development, web development, backend dev, security, crypto, Rust, Lisp, C++, F#, Vimers, IDEers, VSCoders, Emacers.... all sorts.

who
That's why so much of it, and so much of the ruling family, stays outside the country.
The first thing to realize is that the crispr/cas9 strategy only produces damaged DNA (double stranded breaks, DSBs). It is not supposed to repair the DNA or do anything else.

You have five main responses to this:

1) Necrosis/Lysis (cell dies due to malfunction)

2) Apotosis (cell kills itself)

3) Senescence (cell doesn't die but stops dividing)

4) Non-homologous end joining (NHEJ, the free ends of the damaged DNA are just pasted back together by the cells repair machinery)

5) Homology-directed repair (HDR, other DNA around that has a similar sequence to the free ends gets used by the cells repair machinery to paste something in between; eg you have two of each chromosome so use the corresponding sequence on the other one to fill in the gap)

The second thing to realize is that cells containing the targeted DNA sequence will be more likely to have damaged DNA than those without. So once a cell is "mutated" (either because it just existed beforehand, or because it survived the crispr/cas9 treatment), it will have a survival advantage.

The third thing to realize is that often these cells they use can divide multiple times per day, I've seen as high as 12 times a day for activated T-cells. That means in two days a single mutant cell could possibly produce 2^24 = 16,777,216 offspring cells containing the mutation.

Anyway, I think the efficiency of this procedure may have been far overstated. There may be only a very few cells in each experiment that actually get edited, but a few days later when they check, those (already mutated) cells dominate the population due to their resistance to the crispr/cas9 treatment.

Eg, look at extended data fig 1h from this recent paper: https://www.nature.com/articles/s41586-018-0326-5/figures/5

The more cells that die, the higher percent of "edited" cells later.
Say I have a bag of dice one of each of the usual D&D denominations (d4, d6, d8, d10, d12, d20). I draw one at random, ask the models for predictions, and roll it. Model A ignores the information about which one I drew, and predicts a correct distribution of rolls (12.9% chance of rolling a 6). Model B correctly processes the information about which one I drew, and predicts a correct distribution given that information (I drew the d6 so 17% chance of rolling a 6). Both models give correct results overall, but Model B has higher probabilities on average, and I would say it is a better model.

A model should be judged both on how accurately it characterizes its uncertainty and how much evidence it's able to successfully make use of.
Do you think you'd lose any flavor/goodness if you strained it prior to bottling? If you have made a strained or more finely blended version of this were there any key learnings?
It sounds like a lot, but in 10 years it might be pretty manageble.
I use Kraken on every site I do for this reason.
Well shit. I assumed I could upgrade my hardrive 5 years from now. External hard drive it’ll be I guess! Good thing usb-c is fast.
Their hangers must be called teapots. Or would it be kettle?
I enjoyed learning about moais, but the Blue Zone quiz at the end of the article was a complete non-sequitir for me.

I like the simple litmus test that wizardforhire mentioned (https://news.ycombinator.com/item?id=17544755). Another one I like is WaitButWhy's "Traffic Test":

"The Traffic Test is passed when I’m finishing up a hangout with someone and one of us is driving the other back home or back to their car, and I find myself rooting for traffic. That’s how much I’m enjoying the time with them."

(from https://waitbutwhy.com/2014/02/pick-life-partner-part-2.html)
i didnt write this comment - my acct got hacked.
One is going to need a way to debug and study ANY complex query for performance and bugs. EXPLAIN is a tool, not a crutch. "Dot-Chained" API's don't solve this by themselves. In bigger shops one typically has skilled DBA's who are good and quick at optimizing SQL anyhow because of their experience with it. An app-side programmer won't (or shouldn't) do this often enough to become a guru with query API optimization. Modern economies rely on specialization.
Blood Pressure Medicine Is Recalled
Yeah it does feel a bit awkward to watch a stream with no other viewers, if you are just going to lurk. Which probably does make it harder to get over the initial hump. Once a stream has 10+ concurrents and some regulars it is a bit more approachable.
Ditto to the 'who are your customers' question.

You may find that, say, food van operators are keen on a tool that turns their Facebook page into just the type of website that a food van operator needs.

Ditto for a dozen other possible segments.
Not true, Munro does labor of cost assessments as well, not just BoM. If Munro is saying car is profitable then I am pretty sure he factored that in.
Airbnb warned it breaches EU rules over pricing policy
Ask HN: How to find a tech-savy business co-founder?
I'm trying to launch a SaaS startup - still working on the MVP. I'm technical and am building out everything with an eye towards boot strapping in the beginning.

I'm not too concerned about immediate help with the technical aspects (though some code review would be lovely), but I'm aware that there will be non-technical work which I am willing to do, but am inexperienced in. Also, it would be good - in general - to have a co-founder to share the experience with.

I'm currently located in south eastern USA and would prefer not to relocate - but I'm happy to travel for networking purposes.
Amazon’s net income per employee is 33,000 USD [0]. This means every Amazon employee could get a 30,000 USD raise and Amazon would still be profitable.

[0] https://csimarket.com/stocks/singleEfficiencyeit.php?code=AM...
Why does that mean people shouldn’t be able to pick and choose who the talk to on social media?
Thanks for the suggestion. I've never heard them before, this is great focusing music.
It's possible that may contribute. But even my 1.5 year old NVMe Samsung 960 Pro has write speeds similar to that. It uses a standard form factor so I dropped it into a PCIe adapter and use with my 4 year old Z97 motherboard. Being able to do that makes me appreciate standards.
I have friends since university that I would have completely lost if it wasn't from the effort on my side, for us to get together. At some extreme point I had one friend complaining that I was not calling her enough while she never actually did it herself.

We have a great time when we're together and I know that these friendships are very important for me and for them.
At some point I just started assuming that it is part of my role in life... to be the one that makes the phone call.
Possibly not lab-grade white noise, just broadband audio noise in general: fans, moving water, RF static, voice codec comfort noise turned up too loud, that sort of thing.
Apple Celebrates World Emoji Day
Absolutely. The fact that this is ongoing hours later is pretty much a clear sign that there’s problems.

I understand that it’s not always easily fixable. But honestly this looks pretty bad. Could be anything from bad code to a flakey cable.

I got out of high volume websites - too much marketing, unpaid overtime, and horrible work-life balance.
When Google Drive and iCloud and One Drive all cropped up, copying the same service with the addition of deeper integration into different devices and software, I was worried Dropbox would be unable to compete. But they've hung in there, and I remain a happy customer.
Wait, is it harmless or is it going to cause a cluster of diseases in the next few years?? It can't be both!
Scientists identify key step in production of Body Odor
"Up" generally refers to the more powerful, while "down" refers to the less powerful. I don't know what scale of culture you're referring to - if you're just pointing out that power is not fungible/transferable across subcultures, I had attempted to account for that in my original comment ("sideways").
Pneumatic Mail (2005)
A recipe without 10 pages of useless, boilerplate SEO content?
I have the same problem. I get extremely anxious whenever I am in charge of planning a social event but if one of my friends plans something I always have a great time when I attend.
It may be ten years until the next Gilded Age.

https://en.wikipedia.org/wiki/Strauss–Howe_generational_theo...
I didn't reach a conclusion, I presented a possible reason knowing very well that I don't have the evidence to back it. Hence why I said "could it be that the engineering force at Amazon is no longer what it used to be?" and not "The engineering force at Amazon is no longer what it used to be."
I have no rebuttal here, but I'm curious what your thoughts are regarding Bezos's well-documented mistreatment of workers. Why would he do that?
> Given this MacBook's non-removable storage, Apple must have a new recovery method. Any ideas?

None?
A program with more memory controlled by GC is generally going to have more leaks like that.

The switch reduces bugs some, and definitely reduces the severity, but I would largely put the bugs in the same category and say it hasn't been eliminated.
No but I've spent a good amount of time doing vaguely sound-engineering work where I listen carefully to audio samples. I may have overtrained some pattern-recognition wetware along the way.
I don't think he was saying mathematicians don't find it interesting because it lacks sufficiently convoluted mathematics.

Rather a 'true mathematician' (who by definition ignores all practical considerations) would find it unsatisfactory because the problem of finding a way of allowing toilet-less carriages is solved by not allowing toilet-less carriages.

Frankly I think they should have just put the toilet in the middle of the toilet-carrying carriages, but maybe I'm weird.
I thought the same thing when I learned of all the "Let's Play" content on YouTube. There are probably millions of hours of videos of funny people casually playing video games on YouTube. The content comes out so fast, and you can only consume so much of it.
that's unfortunate, it would have been extremely interesting to understand the timeline of actions/events that led to his success! O well
Same here! I recall my dad complaining that it was causing issues to windows when dual booting when I was a teenager. But damn getting a modem working in that era was tremendous bitch.
> 5) Homology-directed repair (HDR, other DNA around that has a similar sequence to the free ends gets used to paste something in between; eg you have two of each chromosome so use the corresponding sequence on the other one to fill in the gap)

I wanted to elide the details, but this is what I was referring to when I discussed CRISPR applications that try to change a nucleotide sequence.

This of course leaves discussions of base-editing aside[1]

1. http://www.sciencemag.org/news/2017/10/novel-crispr-derived-...
>> (...) Noam Chomsky on data-driven NLP, (...)

If you can excuse the slightly combative tone, data-driven (i.e. statisical) NLP is a big potato and Chomsky was dead on the money: you can model text, with enough examples of text, but you can't model language. Because text is not language.

Which is why we have excellent dependency parsers that are useless outside the Brown corpus (if memory serves; might be the WSJ) and very successful sentiment classifiers for very specific corpora (IMDB), etc, but there is no system that can generate coherent language that makes sense in a given conversational context and even the most advanced models can't model meaning to save their butts. And don't let me get started on machine translation.

Like I say - apologies for the combative tone, but in terms of overpromising, modern, statistical NLP takes the biscuit. A whole field has been persisting with a complete fantasy -that it's possible to learn language from examples of text- for several decades now, oblivious to all the evidence to the contrary. A perfect example of blindly pursuing performance on arbitrary benchmarks, rather than looking for something that really works.
The T2 chip?
And what an awful area. Oh it's clean and safe enough. But basically landfilled industrial parks (and Levi Stadium). I despise going to the Santa Clara Convention Center for events.
Our government was barely functional from the end of the Civil War until Teddy Roosevelt's presidency.
You are right that I shouldn't have put them in the same basket.

While Penrose's ideas on consciousness are not considered mainstream (neither by cognitive scientists nor quantum physicists), they don't fall in the infertile basket of:

- people gravitating to the state of science they were "raised into"

- people talking about things they are don't mastered

In this case it is a healthy scientific peculiarity. And who knows, it may turn out true. Or false, yet fertile. As ideas of faster-than-light communication with quantum states - which was flawed, yet gave birth to quantum information (more to this story, and an interesting overlap of non-science and science, in http://www.hippiessavedphysics.com/).
> "To:mmt" would be a local filter (or a localized signal in the filter - implementation detail)

You imply that this distinction doesn't matter, but I assert that it matters very much.

The difference is that a local filter can reasonably be expected to exclude any remote (to my domain, for example) "localized signal" when making a decision, whereas to a global filter, there's no such thing as "remote".

Looked at another way, imagine mmt.example.com with 10 users and mcbits.example.com with 800 users are both served by gmail (and we're the first two early adopters). Then imagine none of my users ever mark From:LinkedIn mail as spam (and maybe even mark it as ham in some way), whereas 25% of your users mark From:LinkedIn as spam and the rest merely ignore it (never marking it as ham, though perhaps reading it, mark-as-read-ing it and/or labeling/archiving it either manually or with a filter).

With two local filters, I would expect my users never to have to search their Spam folder for message from LinkedIn. With a global filter, I would expect the relatively small quantity of relatively weak data indicating From:LinkeIn is ham (which happens to be associated with "localized signal" of instances of "From:@mmt.example.com") to be overwhelmed by more numerous strong signals from your users that "From:LinkedIn" is spam and for my users to have to check the Spam folder for messages from LinkedIn at some point.

The latter is what I have observed actually happens.
Net income, like the cost of their rent, inventory, infrastructure, R&D, advertising, acquisitions are all taken into account before coming to this figure? Or is it just employee costs like salary and benefits? I find that hard to believe, but if it's the case, then they clearly don't have razor thin margins, and what I said before simply doesn't apply to Amazon.
I already have most of these books, including TLPI, and that alone is worth the price of the whole bundle.
How Linux works is also a great introduction.
I believe that I have the right to demand that someone else doesn't use their time to burglarize my house, and if they and other companies have made a side business of burglarizing peoples houses, I think it's entirely resonable to demand that they and any similar company spend time proving that they aren't planning to continue.

(And yes, I realize the houses in this metaphor rarely have doors in their doorways, much less locks, so it's techinally not burglary, but frankly I don't care.)
They look like they have more body thickness and less delineation from the wing than previous generations.
The last couple companies I worked at offered a dinner at ~8:00. There was no pressure to attend and as far as I know hardly anyone did.
Trinkler Software AG Is Hiring a Vue.js Developer with WASM Experience in Zug
Yes, you mentioned the two possibilities that everyone likes to focus on, but not the others which (I suspect) are much more common.

EDIT:

I really mean that I think in some of these experiments, where they only try to cause NHEJ, they just already had mutants in the population and selected for them. Its possible not a single cell was successfully edited but you still have so many cells with indels at the targeted sequence afterward.
That was quickly adjusted. I think like 3 years ago, Amazon publicly was saying that every day to AWS they were adding the same amount of computing power that was used to run Amazon.com when it was a $10 billion business. AWS is massively greater in scale than Amazon.com at this point.
Buy a new laptop?
DSLReports is dying if you haven't noticed, with Karl Bode leaving, there are no more constant news updates. Really sad to watch this corner of the internet die.
JWTs: A secure and stateless way to implement authentication
Fraud in Indonesian Ride-Sharing Services
This is not an on-topic submission for Hacker News.

https://news.ycombinator.com/newsguidelines.html
You're collecting one hell of a lot of personal information here and frankly, I'm not comfortable sharing that level of information without some idea of what you're doing with all of it.

Finally, with the way you admonish people in the IQ section and the brand new, anon account, I'm inclined towards not trusting you.
> That sounds just about like the most revolting and negative endorsement you can make for a business solution.

A lot of these larger software packages support different levels of customization, and they usually press people to use the simplest stuff.

It's not completely possible to guarantee reliability once the customer is writing their own code. You can guarantee the app doesn't fall over, and data isn't lost, but ultimately the customer is free to shoot themselves in the foot, and they will.
you can watch twitch on demand too.
its like sports, sports is more fun live.
Out of curiousity, what does Dropbox do for you that they don't? Have you stayed because of price, service, features, laziness to switch? :)

I personally don't have many storage needs so I just email myself important files, back up some things to USB, and sometimes will add things to Google Drive
Chiles are the vegetable. Chili is the meat and bean stew-like concoction.
Depends I have watched / listened to say critical role whilst chilling in the evening and also whilst working at home.

Though this is partially to pick up tips for when I GM IRL though my players aren't as well behaved :-)
Slackware: Linux at its finest: no cruft, easy to install, just works. No automatic dependency resolution is a blessing in disguise.
Copy on write should be WAY faster than that.

These numbers are similar to the iMac Pro, which uses a similar setup (T2, multiple flash chips).

I don’t think the benchmark was dumb enough to just be ‘cp fileOne fileTwo’, they would have taken the APFS instant copy into account.
WeWork takes meat off the menu as part of environmental policy drive
Haven’t the drives been soldered on board for quite a few years now? At least since the 2016 redesign, right?
Around 1900 is actually a difficult time because that is when they installed gas lines everywhere. The house I just moved in has outlets everywhere to hang your gas lanterns, including ceiling hooks (but no electricity at the ceiling). The gas expert who installed the gas boiler in the bathroom (from the 50s, it appears.. You need to light it up by hand every time you want hot water) couldn't figure out whether there still is gas in there, but said that usually there is..

So at least some part of the plumbing infrastructure is obsolete and a legacy issue.
This article serves as a rebuttal to http://cryto.net/~joepie91/blog/2016/06/13/stop-using-jwt-fo.... It deconstructs each criticism presented and explains why JWTs are a secure and elegant solution to authentication. It also goes over how one would go about implementing authentication securely using JWTs with Node + Express + Passport.js.
Probably incompetence.

1) Don’t think about users’ privacy from the start. 2) Ignore GDPR until the enforcement deadline. 3) Panic and shut down EU until you find something to do.
Thanks anyways.
There's no need to accuse me (an ally) of allegedly forgeting your existence when I was merely trying to give an example of someone who is statistically extremely underprivileged.
"Recovery" meaning what?

When I went to the Genius Bar because my laptop had WiFi issues, they didn't boot from the internal hard drive, they booted from an external unit that seemed to do way more than just function as a USB-external-HD.

If they mean "self-service" recovery, then I don't know that a soldered hard drive is any different from a removable one. It either works or it doesn't, if it does you can recover from a recovery partition... if it doesn't then you can't recover no matter what.
There are plenty of apartments to rent. Purchasing a house is not the end game for everyone, nor should it be. It represents a major investment of time and money in terms of maintenance and upkeep.

And the primary problem with people not being able to afford houses is that they're not able to generate savings due to college loan debt, which is a national problem not restricted to California.
Not sure if when you say CEO, if you are talking about a CEO with his individual personal stock holdings or for the company itself. If its the former, it feels like Mark Cuban did something of the sort with his Yahoo stock with his own personal holdings in Yahoo.

https://www.quora.com/How-did-Mark-Cuban-save-his-wealth-fro...
As someone who is like that: Is it possible they’re just constantly overcommitted and stretched thin?

I enjoy hanging out with my friends, but whenever I do it feels like I have to take great pains to carve the time out of my schedule, reshuffle a bunch of priorities, and try to somehow keep my head above water despite the reduced time in the day. What do them is a “Lets grab a quick drink” is to me a “What am I not getting done this week and how far behind will that put me?”

Hence I never reach out proactively. Any spare time goes to keeping the SO relationshio strong.