skysight-inc/HackerNews huggingface dataset:
No, read the source article.

The validation data are taken at baseline from three previously published studies investigating pharmaceutical interventions to normalize metabolic abnormalities of children with ASD31: (1) a combination of methylcobalamin and low dose folinic acid32, 33 (2) high dose folinic acid,34 and (3) sapropternin.35 Given that these studies all focused on evaluating treatment strategies for ASD, all participants had a confirmed diagnosis of ASD. FOCM/TS metabolites were available for 154 (76% male) participants with ASD with a mean age of 8.8 years (range 2–17 years). These ages are different than reported by Delhey et al.34 because this study only required that measurements be available at baseline, rather than both at baseline as well as the conclusion of the treatment phase. Furthermore, stratifying patients by age or gender did not reveal any differences in the univariate metabolite distributions. The first two studies were approved by the IRB at the University of Arkansas for Medical Sciences and the third study was approved by the IRB at the University of Texas Health Science Center at Houston. All parents gave written, signed consent and patients provided assent when appropriate.

2.3 Metabolites

The metabolites under investigation are presented in Table 1 and additional details of these measurements and derivations are presented in Melnyk, et al.30 This is only a subset of the measurements investigated previously29 because “% DNA methylation” and “8‐OHG” were absent from the validation data set and were therefore removed from this study to ensure that a consistent set of metabolites are used for training and testing.

(Table 1 - 22 metabolic variables considered)

https://onlinelibrary.wiley.com/doi/full/10.1002/btm2.10095

I’m curious if these metabolic abnormalities apply to adults as well. I had an ADOS at the UCD MIND Institute come back with a 7 (1-14 scale IIRC) about 10 years ago.

PS: PKU treatment sapropterin (Kuvan) costs $100k USD/yr
Previous dupe + discussions: https://news.ycombinator.com/item?id=17365366
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If I was the CEO of Tesla Sterling wouldn't have quit, because my strategy for developing autonomy would have been grounded in reality.

My strategy for mass producing the Model 3 also would have been grounded in reality. And I certainly wouldn't have spent $2.6 billion buying a failing solar installation company with $2.9 billion in debt.

The last few years of Musk's reign over Tesla have been marked by colossal strategic errors made unilaterally in stubborn defiance of conventional wisdom and against the better advice of the experts and specialists he's surrounded by. I don't know why you guys keep defending him, he's incompetent. He has an established track record of paranoia, delusions, cronyism, lies, threats and petty vengeance. For all his claims of Tesla's many enemies, the only legit threat to Tesla's future success is Musk himself. Big boy car companies don't operate this way, and for very good reasons. Very good reasons.

It would be a lot easier to root for Tesla the company if it could be separated from Elon Musk the personality cult.
Indeed, at least to a certain degree.

You'd expect a CEO being fired over such a technicality to at least fight back, instead of fully cooperating.
Not just mobile games, but AAA games from major publishers as well. Mechanics that Zynga was pushing out a decade ago in "free" games that were seen as exploitative and predatory are now found in AAA $60 PC and console games.
If they are going to use up to 26 dimensions in their theories, of what use is a machine that only senses the 4 dimensions we normally perceive? Maybe all these missing particles are in some of the other 22? I'm sorry, but I don't think solid answers to some of the big questions are ever going to be found using these experiments.

I also question whether thinking in terms of particles is even the right paradigm. We may be just attempting to mold observations into our own incorrect model.
On the other hand, having local businesses pay less sales tax would be dangerously close to interstate tariffs.
It is, but I think it is a useful discussion of our own personal ethics to have. Take a moment to reflect on some of the scenarios and how you would react to them. Do your principles and your belief system speak to the issues raised?

It is also timely, in that Google and Microsoft are considering or have had to consider their ethics company-wide. Current political events also ask what the United States is willing to accept as a nation.
You may have misunderstood me. It's not about not wanting to pay for value -- it's about putting the right economic incentive to promote the behavior beneficial to the general public (and each individual).

I paid for my lock, but I did not fortify my home. That would be unreasonable, because the society I live in discourages theft, codified it in some rules and actively enforces them, to discourage the unwanted behaviors. And yes, I pay for this through my taxes. I believe I get value for money.

In a similar fashion I expect privacy intrusion to be frowned upon and policed. Surely I have better to do than filing GDPR lawsuits -- or searching for the latest privacy glasses. But I don't want to spend my time searching for such gadgets just because someone on the Internet thinks they're fine.

I don't want the privacy glasses in the very same way I don't want a fortress for a home. I hope you understand.
That wasn't a rhetorical question. I'm genuinely curious if this is ethical or not.
It's even faster than the newest I7 8650U
Kind of a step by step walk that takes you through this:
https://alexvermeer.com/getmotivated/
Your absolute first priority is to raise this as an issue and make people aware of your concerns. Explain how you ended up where you are, what options are to remedy / alter the situation, and their relative pros/cons/odds of success/associated timelines.

If you speak up and try to address the problems, you might be ok. If you sit silently, suffering, and then ultimately fail and have no reasonable answer to management's obvious question of "how did this happen?", then you're going to probably get hit with a big stick and you "quitting", might no longer be an option. Good luck.
Actually taxes on consumption are far more effective and fair than taxes on property.
The problem is that everyone does it. That dumbass idiom should be swatted down at every opportunity. It's the motto of an entire generation of right-wing "centrists" in the USA who have no ability to evaluate their ideas in a larger historical context and so pick the middle ground between center-right and far-right thinking it makes them savvy paragons of compromise.
>>> "We're trying to recreate Neanderthal minds," Muotri says."

Get the pitchforks. This scientist has gone too far. Really. I'm a totally against growing "minds" in jars. I'd be against doing this with any animal brain, let alone something functionally equivalent to human. There are ethical lines that shouldn't be crossed. The concept of a non-corporeal mind living a non-sensory existence in a jar of goo is too horrible to be allowed. This nightmare should live only in the pages of science fiction.
High Court: Online shoppers can be forced to pay sales tax
procrastination is a fuzzy thing too, I used to LOVE discomfort, because I had this desire to feel capable of achieving anything. Could spend hours, days thinking and trying things.

These days I don't, it's not about discomfort, I need something more human and wise behind my efforts.

I'm sure most parents know that, I've seen some that were demotivated, but when their family started, they were moving everything around.

A balance sense of purpose is worth a lot there.

ps: a distraction heavy context is also bad. ironic :)
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I apologize for not clarifying. I was primarily selling out by compromising my preferred career path for a less desirable one (in my view at the time).

I don't regret the decision, and I ended up really enjoying the five years I spent working in the energy industry. However, at the time, I definitely believed I was "selling out".
>Yeah I never understood this either. Does that mean a bachelor US president can't date a US citizen?

Is the difference in power between a US president and the given citizen larger than the difference in power between a 18 and 15 year old? If so, and if relationships should be banned based on power differences, then it seems the only logical conclusion is such a relationship should be banned.

Then again, our laws and social morals are rarely so consistent.
I mean if you're already offering a tax compliance service for 50 different sets of books does it really get that much more complicated adding more?
Thanks for discovering this. Good read.
IANAL, maybe there is some way to revoke the trademark http://manuals.ipaustralia.gov.au/trademarks/Part_62.pdf

Have you agreed any IP rights transfer with the supplier before? If yes then maybe these could be used to bounce them or make a settlement.
Thousands of Mobile Apps Expose Their Unprotected Firebase Hosted Databases
> Procrastination is the avoidance of activity due to a discomfort/fear/anxiety and subsequent inability to scale the discomfort wall that exists between you and the tasks' completion.

Perhaps this is wrong, but I feel like another important (and possibly most common) source of procrastination is not avoidance, but rather simply getting more enjoyment (dopamine/etc) of other activities. Ie, I don't think I have to be avoiding work to procrastinate, I may simply get more dopamine from Reddit-ing and thus mentally prioritize it.

Focusing on why your work or w/e you're procrastinating from is often the wrong approach in my opinion. The competition for tasks being avoided are typically pure entertainment, all dopamine and no effort. Tasks that are "meaningful" such as work, learning, etc often can't compete with entertainment for your brains drug dependencies.

Instead of focusing on tactics to improve procrastinated tasks, I've found my life is better when I instead limit their competition. I've had serious Reddit problems in the past, where I become basically addicted to it, and so my brain keeps injecting Reddit it any time I'm compiling or w/e. If I instead break that habit through heavy limitation of the dopamine provider, I've found myself to be far more productive.

Now methods to make tasks you want to do give you more dopamine are always welcome. I love micro-todos, and found them to be pretty effective at giving me a sense of accomplishment and, I imagine, dopamine. But micro-todos will never compete with pure entertainment, so I need to cut that. Or, at the very least, cut it from my default response of when I'm having spare brain cycles (like compiling) and jumping to fill it with entertainment dopamine.
Your first sentence is why part of hardening systems is getting down to a bare minimum footprint of installed software.

To your second question, cloud vendors are generally very happy to sell you threads instead of cores on multi-tennant hosts. So, almost certainly- if not with this attack, than with a Spectre variant or something as yet undiscovered/undisclosed. If you want to avoid that some let you pay extra for dedicated hardware.
One particular question is my use of Page Plus, my phone carrier. It was the first Verizon MVNO to get 4g.

I was on an automatic payment with them, and they announced that they were adding 911 taxes.

I canceled the automatic payment and started getting refills at pincheap.com (a dealer with no presence in either Iowa or Illinois), avoiding both sales tax and the 911 tax.

There is no "delivery" of any physical product, so I wonder if the tax status of that arrangement changes.
Can you prove or disprove that she did not have a language ?
That's not how you guarantee there'll be no slums though. You just guarantee you move the slums somewhere else, which is not really a solution for anyone.
There’s a point of view that short selling is important & ethical because it creates an incentive to find problems with companies and expose them. Hopefully they’re honest when they do it, but that applies to people pumping a stock too.
that's lovely, but thats not the point ;) first you try to not buy it. if you have to buy and have extra garbage, try to do something with it to avoid disposing. if you can't, then try to recycle it. it makes sense
Putting the brakes on metastatic cancer
> This is a reason I love having outspoken and extroverted devs. The guys who love to talk so much that they will explain in extreme detail and at length.

In my experience, the devs that talk the most, know the least about how things actually work. They churn off trying to explain something and are either subtly or blatantly wrong, and you've got to reel them in before they get down the rabbit hole and misrepresent reality too badly. It can be catastrophic if they are interfacing with management or customers.

It seems to be a manifestation of the classic "baffle them with bullshit" strategy for dealing with ignorance or incompetence.
Sales tax has one of the most complicated structures. Recently ADP built logic to tax according to counties and sub-zones (not just states and cities) to save millions on taxes for its customers. I doubt small start-ups can afford their software. It will be great if Stripe can come up with an API to simplify this. Or else, its clearly a win for large retailers and not as much for small ecommerce stores.
It is not hard to get the right rates. All you need to do is have a master file with all zip codes with the corresponding rate to charge. The difficult part is filing out the returns and dealing with potential audits.
The US startup is disappearing
Shorting a stock does not make automatically make negative opinions about it invalid any more than going long makes positive opinions invalid. The whole point of shorting, and the reason why it's legal, is to give people incentive to find overvalued stocks and thus correct valuations.

It's like people with a negative outlook on a company can't win: if they short, they're accused of being biased. If they don't short, they're accused of tossing out accusations with no skin in the game.
Look into the field of computational semantics. There is absolutely nothing in your comment which cannot be represented in existing logics. Metaphors and such are no problem.

There is ambiguity in natural languages so the determination of underlying meaning is at best probabilistic, but we have ways of handling that too.
If you have money you have better lawyers. If you have money you can settle many things outside court. If you have money, many sentences do not take your income into account but have a fixed amount, and you pay % less than others.
That's only practical for a single datacenter. You still really need asyc replication across geographic boundaries with a failover mechanism.
There is a huge performance and memory difference between boxed and unboxed types.
I was working as a defense contractor doing DoDAF architecture, documenting existing intelligence programs which had been funded under the global war on terror so that they could receive traditional funding when that budget went away.

I worked for a subcontractor. The prime contract holder's boss found out that I was a software engineer, which they needed very badly on another project: it's untoward to just steal your subcontractor's employees, but they didn't care. They offered me a 25% base salary raise, a fast-tracked TS/SCI clearance, and travel to Afghanistan with hazard pay.

I went and interviewed, and they wanted to hire me, but the nature of the job became clear during the interview itself. The job was writing biometrics tracking software for use in Guantanamo Bay and Afghanistan.

I refused. They called me pretty consistently for the next three years. I just knew I wouldn't be able to sleep at night doing something that was so very contrary to my beliefs.

Now yeah, I stayed at the architecture contract for a long time, and that was contrary to my beliefs too. I had no business doing defense contracting in any form. But that was a boring, actuarial, technical evil; the biometrics stuff would've been a constant in-my-face reminder of the wrongness.

What finally ended my defense gig was that I was reviewing a powerpoint slide which included a little graphic labeled 'squirters.' 'Squirters' are the survivors of indirect fire who run away from the impact site. I couldn't abide the fact that we dehumanize our foes with that kind of vocabulary, and even though I was just building useless budget-justification documentation for existing systems, I didn't want to keep doing it.

Recently, I got recruiter spam with a big number attached. They wouldn't match my scrappy startup employer's upside potential, but the base salary was appealing compared to the lottery tickets. I met with the CTO, who desperately needed someone to run the engineers and serve as a backup repository of institutional knowledge in case he got hit by a bus, but I didn't like the way he talked about the women in the bar where he chose to conduct the interview.
What a mess. Even if Musk decided to go the route of suing this person why did he publicize it himself? What is to be gained for him in the court of public opinion?
Many online payment gateways already offer some kind of sales tax API. Keep in mind in California, sales tax changes per county. In places like Tennessee, the tax rate can change if your item is a grocery or isn't a grocery.

There are companies that already sell massive lookup tables or API access to calculate a lot of this stuff. I think for most retailers, this won't be that big a change.

Most mom-and-pop online stores have disappeared too. Gone are the days when you went to Pricewatch.com and Pricescan.com. Now all the individual shops just create a store on Newegg, Amazon and eBay. I'm pretty sure the big players will start offering up tools to do these calculations for them as well.
Tangential...

I'm still not ready to accept incels as people essentially needing assistance, but: https://www.vox.com/2018/6/20/17314846/incel-support-group-t...

I mean, if you react to depression with misogyny and by lashing out at women, I find it hard to pull up compassion for you, but at the same time, is this because our society is failing to treat depression or emotional damage properly ("getting sex for incels," via prostitution or whatever, is a complete non-starter -- the very last thing we need in our society is more impetus on women to just close your eyes and "do it")?
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The AI winter happens when outside hype and investment money overshoots what can be delivered in the timescale needed for good ROI. Disappointments are followed with periods of underinvestment.

Neural Networks are already decades old invention. Underlying all this new boom is the same basic architecture, alternating layers of affine transformations and nonlinear transformations trained with backpropagation and gradient descent.

What made the field suddenly explode was GPGPU's and bunch of tweaks that helped to solve vanishing/exploding gradients problems (started with RNN training layers and now with skip connections and handful of other techniques that make deep networks possible) combined with better regularization etc. I'm not trying to downplay the innovation, but from the larger point of view they are technical tweaks.

There is limit to where tweaking/scaling the current techniques can go. There needs to be leaps.
Geoff Hinton made the case better in his "What is wrong with convolutional neural nets?" https://www.youtube.com/watch?v=Jv1VDdI4vy4 see also https://arxiv.org/abs/1711.11561
from Jason Jo, Yoshua Bengio. The same "what's wrong with" applies to the field in general.

Hinton's capsule networks are attempt to take another leap forward. Just like with his earlier work from 80's that culminated around 2006, it may take years and years of slow work to get there. Hinton suggests that there needs to be unsupervised learning revolution that comes up with something else than backprobagation. https://www.axios.com/artificial-intelligence-pioneer-says-w...
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I think this is mostly related to ethics, but it can also refer to having you do something that you normally wouldn't do that is ethical, but you can be paid off to do.

I have an example - I'm an average software engineer in the midwest making $170K/year in a great field, and I've been offered a position in Dubai, in an outdated industry, making somewhat less salary, but 0% taxes and a housing and travel allowance.

Here is the thing - I love my current job, love the field, love the local weather, culture, apartment. I really don't want to move, don't really like the new field, really don't like living in Dubai (lived there for six months) - but, Net of Travel/Allowance/Salary/Housing/Taxes, I'll be making $50K more in pocket

At a certain point, money can buy your unhappiness. I guess we'll see if $50K is enough to do that for me.
Spiral Dynamics Red Level?

Found the guy who made Gurren Lagann his religion.
Cleaning up a loophole that evens the playing ground for different types of businesses is a good thing. If you have a problem with sales tax or taxation in general that's a different issue.
Palantir is pretty good at optimizing against people who are just in it for the cash.

I liked working at Palantir because the work was important and the company's actual ethics was very strong, contrary to the impression you might get in the press. I thought having a company with that kind of ethical beliefs doing the work that other people would be willing to do, but worse, was better for the outcome I wanted.
Payment processing services could certainly build out their own solution to collect and remit sales tax, but a lot of merchants sell on a variety of platforms and channels. For instance, a merchant might sell on Amazon and their own eCommerce site powered by Shopify. They might also have an ERP system as a "single source of truth" to record all of their transactions. Each of these platforms collect sales tax differently, possibly providing automatic calculations or simply leaving it to you to provide your own rates. This can get complicated very quickly and a payment processing service only has insight into the data you're passing over to them.

That's why companies like TaxJar and Avalara are focused on sales tax -- to integrate with every shopping cart, payment processor, marketplace, accounting, order management / ERP platform out there to combine all of your transaction data and determine how much sales tax you need to remit in every state.
If the purchaser has an address in an area with taxes, you then pay it. If they do some weird VPN workaround and billing address in the Cayman Islands, then you don't pay the taxes. It's self compliance. We sent men on the moon in 1969, this isn't rocket science to calculate a tax bill.
My one year old does sign language.
What is NVMe, and how is it changing enterprise storage