skysight-inc/HackerNews huggingface dataset:
On further thinking, I'm not even sure what happens in the case of a patient receiving a pre-approval drug outside of the trial. Handling their data would likely need to meet the same standards required in trial (consent tracking, electronic signatures, etc) without any of the machinery of the trial to help. It could well be the case that nothing is collected if the cost to keep it and use it are too high.

IIRC, some of this was handled by FDA (or could have been), if they were part of the process by granting an unapproved treatment waiver. This way some amount of 'informal' data could be collected and used to guide others, even if the treatment was outside of a formal trial. Now, without FDA having a role, I fear that none of this data will be captured (or at least not in a useable form).
To be honest the current White Hart is better than the previous façade which had a mix of shops underneath (I used to work nearby).

Even then it looked nothing like this view from 1827
https://collage.cityoflondon.gov.uk/view-item?i=1311 so it's always been an issue.

In this particular area of London I'd rather they knocked down the façade than try to keep it, unless it has particular merit (although there are less listed buildings (600) than I would have thought in the City).
Also for your health - lots of plastic bottles are not so stable and less so, in heat. So you end up drinking small amounts of plastic and additives.
Local sales taxes are sometimes earmarked for a specific purpose that improves the local community. For example recently voters in the Los Angeles county approved a sales tax increase to fund new Metro lines [0]. It seems fair that since this Metro line primarily benefits residents in this region, this additional sales tax should only be charged when one buys products in this region (primarily residents). Concentrating all the money at the federal level and then redistributing doesn't seem very fair.

[0]: https://ballotpedia.org/Los_Angeles_County,_California,_Sale...
How much is it? I can't seem to find the price.
It's a shame that this wont apply to us here in the 51st state. US companies will continue to drive on UK roads, use UK security and UK law and UK infrastructure to access UK consumers, and will continue to pay less tax than me.
It's use as a verb also makes it feel slightly odd when you refer to it as a noun, compared to Alexa for example which is a name.
Yes.

Text as introduced is here: https://leginfo.legislature.ca.gov/faces/billTextClient.xhtm...

All the intermediate versions are there, too, you might actually want to start with the most recent version prior to the hostile amendments rather than the original text.
You must have a terrible opinion of archaeologists if you think that only a thousand years from now they won't be able to tell a data storage device from a cerimonial item.
Not to mention listening to peoples inane phone conversations, and having to shove other passengers legs out of the way when they think they can encroach on your seat space.

Bus drivers also tend towards the unpleasant. I realise it's a stressful job but that doesn't make my commute any better.
Yeah, i had a client using it who found that being able to get the data into a reporting scenario so they could file was hard. Mostly it surrounded reconciliation and an ability to gain confidence that the numbers reflected actual transaction volume (it is a perishable good, so there was a reasonable quantity of discounts and refunds as delivery vendors missed targets...)

I'd also say I have a bias, as I've also used avalara a couple times before and found it to be quite a bit superior in making it seem quite a bit more effortless -- taxation is so byzantine I don't have any expectation that I could understand it, so I want to trust that the provider i use is very confident they do.

not sure if that helps a lot, but it was also a few months ago ;)
My startup paid monthly, which was the least work. But then some employees wanted bi-weekly, and others pointed out the semi-monthly made more sense because it aligned with rent payments. Switching is a fair bit of work. I would have loved a feature that lets people get paid whenever they like.
Bitcoin Makes Historic First Appearance in US Supreme Court Opinion
Day trader tries out demo platform ends up with actual 5B position
Adding a rain screen facade with an air barrier to buildings reduces the energy consumption. And why not have some fun with the design. I don't think anyone's going to be laughing, its just going to become the norm.
Aren't we sort of starting down that path already? IIRC Chrome only allows certain operations on HTTPS domains as of late such as webcam or microphone access.

It seems like this sort of iterative securing of different things over time could be a good way to secure the web while also giving time for older sites to upgrade.
Tesla's Silly Falcon Wing Doors Have One Great Function
My boss just dropped the offer salary for a new candidate by 25% because they weren't from a top tier school...I really hope they still accept b/c I _really_ need the help! I know that's a bit different than what the article is talking about but still similar reasoning. They were the strongest performer on every metric we have and for no other reason than the name of the school they did their graduate work at, they are getting a significantly lower offer. Really makes you question the value of the metrics in the first place, doesn't it?!
0.4.15 currently. There are some things that are not production ready (in particular IPNS), but the basic infrastructure (the distributed content-addressed storage) is pretty solid. Discovery also works pretty well. NAT hole punching is impressive. Resource usage is low enough that you can run it on a raspberry pi with some room to spare.

For IPNS I am using the DNS txt record workaround until IPNS gets more stable. See http://blog.klaehn.org/2018/06/06/publish-blog-on-ipfs/ for how that works.

I am publishing the blog and several static pages on ipfs. So far it works really well.
And just because this kind of thing is fun, if you use the right kind of pattern on a big enough file, SIMD can be quite noticeable:

$ rg-with-simd --version
ripgrep 0.8.1 (rev 223d7d9846)
+SIMD +AVX
$ rg-without-simd --version
ripgrep 0.8.1
-SIMD -AVX

$ time cat OpenSubtitles2016.raw.en > /dev/null
real 0m1.280s
user 0m0.020s
sys 0m1.257s
$ time wc -l OpenSubtitles2016.raw.en
336602465 OpenSubtitles2016.raw.en
real 0m4.303s
user 0m3.132s
sys 0m1.167s
$ time rg-with-simd -c 'Sherlock Holmes|John Watson|Professor Moriarty' OpenSubtitles2016.raw.en
6033
real 0m2.099s
user 0m1.750s
sys 0m0.347s
$ time rg-without-simd -c 'Sherlock Holmes|John Watson|Professor Moriarty' OpenSubtitles2016.raw.en
6033
real 0m4.128s
user 0m3.781s
sys 0m0.343s
$ time rg-with-simd -c 'Sherlock Holmes|John Watson|Irene Adler|Inspector Lestrade|Professor Moriarty' OpenSubtitles2016.raw.en
6731
real 0m1.989s
user 0m1.621s
sys 0m0.366s
$ time rg-without-simd -c 'Sherlock Holmes|John Watson|Irene Adler|Inspector Lestrade|Professor Moriarty' OpenSubtitles2016.raw.en
6731
real 0m18.417s
user 0m18.000s
sys 0m0.403s

Looks like `cat` is still faster, so there's some room for improvement. ;-) With a single pattern, we're almost there:

$ time rg -c 'Sherlock Holmes' OpenSubtitles2016.raw.en
5107
real 0m1.333s
user 0m0.974s
sys 0m0.357s

This one is mostly thanks to glibc's memchr implementation (which uses SIMD of course), and the regex crate's frequency based searcher.

Of course, I'm presenting best cases here. Plenty of inputs can make ripgrep run quite a bit more slowly than what's shown here!

The crazy thing is that we're still only barely scratching the surface. Check out Intel's Hyperscan project for some truly next level SIMD use in regex searching!
Detecting Kernel Memory Disclosure with X86 Emulation and Taint Tracking [pdf]
Then go to live inside one of those horrid abomination of buildings if you really like them.
From my point of view I can’t wait until someone finally decides to get rid of those brutalist monstrosities.
You're taking this the wrong way; I'm not saying that jobs or housing should be directly limited. I'm saying that it's the job of the governance of a region to fulfill the needs of it's people.

Need for housing ~= {jobs} + {adult students} + {unemployed} + {retired} + {liquidity room} - {All housing in the market}

If the need for housing is positive than actions should be taken to accelerate and promote the development or re-development of new planned accommodations.

If the need is /dire/ (as it is for the large west coast cities) then that the government should take on the buy out and re-development of entire neighborhoods in to areas that are suitable for the continued health and prosperity of the whole (as private interests have clearly failed to do so or regulations have not allowed them to do so).

This planning and redevelopment should also include mass transit and other resources as well as more than meeting 'minimum code' for all construction. (My own views about the inadequacy of such codes are out of the scope of this topic.)

That would help prevent the decline of public transit.
Kitchen appliances are starting to use DRM. Should They?
What? US companies have to pay VAT in the UK, just like anybody else.
The Wall Street Journal refers to the DJIA more often than the S&P 500, and they have a reasonable business section. They mostly do it because they're tied up with it, though.

No great loss to them, TFA notes that they're well correlated (and gossip about GE sells papers on slow news days.)
in this town there would be simple solutions, first is that here if you need to get anywhere generally you have to take not one but two buses, this makes it petty expensive, but thats not the biggest flaw.

oh no, the main problem is one of time, none of these buses match up so despite being a mere 3-4 miles an average commute via public transport is well over an hour, not only that but the timetable is not even close to accurate, youll often wait for a bus marked on the digital info boards as coming any min only to find that bus actually never existed and you have another 30 min wait

basically if you want to get to work on time be prepared to leave at least 2 hours early. you may be thinking "hey its only 3-4 miles, just walk you lazy bastard!" but sadly again this town does not lend itself well to things such as walking or cycling because there is no such thing as flat roads here, youre either going up a steep hill or down one

a reasonably priced tram system or even a properly organised and reasonably priced bus service could fix these issues easily but sadly that will never happen
You can uninstall or block extension, you can't uncompile RCE or trojan or whatever.
Quantum computing is coming. How quickly isn’t clear, although the first versions of this technology are expected to begin showing up over the next few years, with the rollout across more markets and applications expected by the middle of the next decade. https://semiengineering.com/quantum-computing-becoming-real/
I would love to think the world is so black and white, but we export plastic to China and now, they don't want it. So.

It's always dangerous to think one is on the right side of history.
Just wanted to say -- Focusmate is amazing. I've used it a ton. I don't know how, but it helps me get into the zone almost immediately. The idea of working with a stranger on the screen seems weird when you first hear about it, but it's amazing how the impact is almost magical.
That's a good reason why a court could order that an LLC be allowed to mask its ownership, but not a good reason why all LLCs should be allowed to do so as a blanket policy.
You’ve just described variation as a way of mitigating the effects of variation.

There’s a case to be made for variation, but that ain’t it.
My impression from browsing these discussions is that the set of rules governing sales taxes even in a single state are sometimes more complicated than those for all of Canada. It's pretty incredible to see all the fancy tax rules.
>Q-line

Most American streetcar systems suffer the same fate: Shiny but slow, much like a theme park monorail; and sold first as a way to boost property values and economic development. They are designed to do everything except provide a useful way to commute.
Watching a species vanish in real-time
The other responses were useful. Yours is just a put-down. Why bother? To discourage "middlebrow" comments? But the one you're responding to elicited useful information, so it's hardly a problem.
I spent the last couple years working at a company in a highly-regulated space. I agree with the comment you replied to, and "selective enforcement" is not how I'd describe it.

Think of, say, a teacher. Suppose a teacher gives a complex assignment, provides contact information and says students can and should ask questions, submit drafts for feedback, etc. And there are two students who take different approaches. Student A simply glances over the assignment sheet, goes off and does what they want, then hands it in on the last day. Student B asks questions early and often to clarify anything they're not sure about, runs a draft or two past the teacher, and makes changes in response to feedback.

Student B is much more likely to get a good grade on the assignment. Student A is much more likely to get a low grade out of the blue for making serious mistakes.

And this isn't selective grading, it's just a reflection of the effort each student put into getting the assignment right. Both students had equal opportunity to put in that effort, but only Student B actually did, and it shouldn't be seen as a problem if Student B's diligence pays off.
> It's easy to compromise and take public transit instead of a car when the public transit saves you time.

And/or money. The public parking in the city is prohibitive, alone.
That makes it a book in which some statements are social reflections rather than statements rooted in good science, which makes other such statements somewhat suspect.

It doesn't mean you should reject the whole thing out of hand but it might be a good idea to try to figure out how much of it is todays bias rather than good science in cases where that is warranted.
You're still better off if most of the poison stays inside the plastic than if you were to eat the same amount of poison without the plastic.
Twitter's Smyte acquisition/shutdown took down NPM
Will this finally allow us to implement the mkdir system call in terms of mknod and link :-?
> I have had a hypothesis for awhile that the economy is going to see a lot more post-retirement startups.

I think you are overestimating the economic state of most retirees. Also, startups are risky. Old people do not like risk and venture capital isn't going to throw money at older people nearing the end of their life.

> I floated the idea of trying to start a business with one of her hobbies.

So self-employment rather than a traditional "startup".

> I know several retirees that have done something similar, most go into a consulting role/function helping newer companies since their knowledge and experience is their #1 asset.

So taking jobs from younger people? Don't see how good this is for society in general. You shouldn't be allowed to collect a pension/social security/etc and work. Just my opinion.
Sketchpad listing at the Computer History Museum:

http://www.computerhistory.org/collections/catalog/102726903
I wish font rasterization used SIMD more, but it frequently doesn't. The final blitting step usually does, but important things like the Gaussian blur used for subpixel AA color defringing are still not accelerated on Mac, for instance :(
I think you hugely overestimate the number of people who can ride a bicycle for 24 miles - let alone those who can do that in 2 hours.

I ride a bicycle a 3 miles to work every day, and while I'm sure I could work up to it I'm not entirely sure if I can do 24 miles without stopping because I haven't done it in so long. And keep in mind my 3 miles commute is more than the vast majority of westerners ever do - I probably have a higher base fitness just by using a bicycle at all.
That’s a relatively unusual leaning. Most people think their values should be universal.
Talked to a former colleague and apparently he may have a real estate investment company also. Spoke too soon!
Lobbying power isn't just a factor of market cap. For example, consider how media groups such as the RIAA and MPAA have pushed for ever more intellectual property laws despite being smaller than the groups that would benefit from copyright reform. Similarly with Article 11 and 13 of the proposed EU digital copyright directive.

There's only so much money you can throw at lobbying: beyond a certain point there's diminishing returns, not to mention the criticism (warranted or not) that lobbying tends to atttract. Industries that employ more people or have a strong local presence can also punch above their weight. And of course, much as we might pretend otherwise politicians are capable of holding their own opinions, too.

It's not just AT&T that's opposed to this bill, either. A wide range of cable companies and ISPs are lobbying against it:

https://arstechnica.com/tech-policy/2018/04/att-and-cable-lo...

> AT&T and the lobby group that represents Comcast, Charter, Cox, and other cable companies have been making their displeasure known to lawmakers in advance of hearings on a bill that could impose the toughest net neutrality law in the nation. The California bill implements the FCC's basic net neutrality rules from 2015, but it also bans paid zero-rating arrangements in which home or mobile Internet providers charge online services for data cap exemptions.
It sounds like you just don't like BEAM/OTP, then. :) I don't know if I would make a sweeping recommendation for Rust as an alternative to Erlang based on that, though, as I would imagine it would take a TON of work to replicate OTP in Rust.
Reducing advertising fraud with adChain’s token-curated registry
I had never heard of tags before. Thanks!

So, would this work?

ports:
https:
enabled: yes
!!int port: 443

Then if someone is copy/pasting and tries to use "blah" as the value, the !!int tag would cause the yaml parser to throw an error. Right?
Shouldn’t this require an amendment to the constitution, to eliminate the constitution’s clause forbidding the taxing interstate commerce?
I'm not a heavy user of Postman so I can't say if the UX was improved by it, but Postman actually moved to Electron last year: http://blog.getpostman.com/2017/03/14/going-native/
The company managed to convince California Assemblyman Miguel Santiago to introduce a series of last-minute secretive Tuesday night amendments that were then voted on without debate during a Wednesday morning hearing:

So, find out all those who voted yes on those amendments and picket their offices after inviting the press then primary them out of office. Rinse and repeat until they don't have someone who will introduce legislation for them.

Don't succumb to thoughts of "well, they're good on other stuff" because then you really won't be effective. Don't try to educate them, just discard them and make sure the next politician understands what is not allowed.

Focusing on AT&T is a waste of effort because next time it will be Verizon or someone else.
The question isn't if the region you're investing in is going to have high growth.

Most retail investors make the mistake of assuming high growth = it will be a profitable investment. In fact, the companies and countries that are talked about in the press as being "the fastest growing" are typically the worst investments. How is this possible?

Because everybody else has also purchased that investment thinking the same thing you are and pushed its valuation beyond even high growth levels.
> So clearly you can have technological advances without any productivity growth.

A little perspective is required. From the 1860’s to the 1960’s we went from candles and horses to computers and the moon landing. In the past 50 years nothing comparable to electricity, automobiles, flight, space flight, antibiotics, refrigeration, computers, telephones, radio, nuclear power, etc. has been invented. We have only refined technology invented by our great grandparents. Our civilization is stagnant and incapable of producing the kind of people who can move us forward. And, when the population begins to decline, we’ll begin to regress. Our great grandchildren might only read about airplanes in books.
I know Lua and I use it sometimes (for example in Redis). But I don't want to include a full Lua interpreter in my program just to parse a configuration file. It's overkill in my opinion :-)
It's same in Ukraine, I'd even say tax rate differences are less ridiculous in Poland. In Ukraine personal income is taxed at flat 20% and another 22% of income goes to social security, while sole proprietorship income is taxed at 5% plus 22% of minimal monthly wage (which is something around 150 USD. yes, monthly) to social security. Everybody from IT people to supermarket chains and restaurants abuse this.

Also, since you don't hire people, but contract some other company it's de-facto at-will employment in country with Soviet-era Labor Code still in place.
Governments need to fund their operations, and allowing some businesses to dodge taxes because of arbitrary geographical differences is unfair and distorts markets.
So how is this going to work? Imagine you're a small online retailer and people from every state buy your stuff. Does that mean each state can send you a tax bill? Without knowing what you owe? And what if you ignore it? What recourse does the state (that you don't live in or don't own a business in) have? Seems like none or very little. Plus, the administrative burden could be quite large for any given state. And it's a crapshoot from the state's perspective, since the state has no idea which retailers are heavily used in their states. I wonder if the states will work together on collections and figuring that part out... Seems like in the short term small sellers will be ignored by the states and the large sellers will loose. Mid to long term -- who knows... Obviously, I'm guessing.

And another thing... The idea that the states are "losing out" on revenue seems like a very simplistic way to look at things to me. First, the states have undoubtably already adjusted their tax structure to get the revenue they want/need. Lots of things affect that and the states adjust all the time. The weather (literally) for instance. It's not like there's an unaccounted for shortfall.

Second, the retailers in question are always local to a given state and their online businesses contribute to their home state's revenue. If those businesses have the administrative burden of managing sales tax across fifty states they may contribute less to the given state's revenue. Or -- they raise prices.

I think it probably hurts people starting up the most as it effectively creates a lot more regulatory risk.

In any case, an economic drag as all bad regulation and regulatory uncertainty is. There's huge uncertainty here as who knows what/if congress will do. "Nothing" is a certitude for a few more months at least. Probably a few more years. Just long enough for it not to be worth creating a business around solving the problem.