skysight-inc/HackerNews huggingface dataset:
>There’s little evidence that ALS patients, especially those with advanced disease, will benefit from NurOwn. In BrainStorm’s Phase 2 study, NurOwn was unable to slow the progression of ALS compared with a placebo. The company turned to a responder analysis to eke out a signal of efficacy, which it’s now trying to confirm in the Phase 3 study.

Here, you seemed to have missed this part.
I've never been able to tell when my blood sugar was high or normal just by how I feel alone.
"the universe is" is just another version of Ayn Rands "Existence exists" (A = A).

But "the universe is" is just tautological I.e it doesn't help you understand the universe any better and you still have to define what you mean with universe even your [0] will run into all sorts of problems (like what is time, what does it mean something exists etc)

It's it's own axiom and conclusion in the same sentence.

Gödel proved that mathematically and logically with his "incompleteness theorem" but you can also as I did above show it in different ways.

And you are right I am not questioning the message I am questioning the assumptions of the message. As I have said other places.

You obviously can't have a normal everyday discussion like that i.e. we normally speak with a lot of assumptions many of them completely unfounded and still manage to get productive results.

But philosophically this is a different discussion where you are forced to question the assumptions of your axioms.
So my estimate is that this is going to happen approximately never.

The challenges to offering a direct DOM api are numerous. The DOM API uses the full complement of javascript types; whereas WebAssembly only has integers. So you need to either standardize a binary representation of javascript objects, arrays, functions, pointers, etc., or you need to modify all the hundreds of API calls to use different semantics, e.g. a C-style string for a node name, a wasm function-table index for a callback.

References of all kinds would be a huge sticking point, especially with garbage collection involved. If you store them c-style as integers, then how do you dereference them safely, or what if you add 50 to a reference etc. If they're stored as opaque references then that's an entire new system added on to wasm.

All of this could be done in theory, but I don't see it happening with WebAssembly. WebAssembly is a deliberately conservative and simple project. It was partly a reaction to the more aggressive NaCl project which had threads and its own low-level API pepper etc. WebAssembly is moving at the glacial pace typical of browser consensus, and the stakeholders involved don't actually want it to take over the web ecosystem (Apple doesn't want web apps to be as good as App Store apps; Google doesn't want opaque web apps that can't be easily injected with ads and analytics; Mozilla doesn't want the browser to be a simple, commodity VM).
It used to be the FDAs job to monitor and report if unapproved therapies (which could be used with a waiver) worked or not. Now, there’s no one to provide that role, so the best you’ll get is anecdotal evidence. Removing the FDA from this process doesn’t help.
"for an industry that has some of the highest profit margins of any"

Big Pharma profitability generally is pretty good but not stellar, unless you only look at profitable drugs and ignore unprofitable drugs.
> Well, that’s what you get for interpreting idioms literally.

How do you think it should be interpreted? The parent interpreted it correctly and asserted it was wrong.
I'm sure everyone has that number, but this story makes no sense to me.

They offered a 25% increase, to "GO TO AFGHANISTAN". Moral questions aside, that is a normal job to job bonus. Not a sell your soul bonus.

You can make 100k a year in Food Service, working at Taco Bell on base in Afganistan. The risk isn't great, but it is a real and present danger when you work in a war zone on a base that might be attacked.

It seems like a 250% increase would be required to get anyone to move.
Prices are determined by what people are willing to pay for things. A video card isn't a requirement to sustain life, it's a luxury. If people think $1000 for one is too much, they simply won't buy one. Obviously a business wants to maximize profit, but it's up to the consume to decide if it's worth it.
Central Europe: GTX 1060 is still 20% more expensive than it was at a low point, so still a long way to go.
There's https://nodekit.io/
But it seems it's a dead project :-(

And https://github.com/zserge/webview
doesn't seem to offer a lot of cross platform functionality
uh, no?

> [then] it was given biased samples
Adobe InDesign or Illustrator at the high end, Powerpoint, Pages, or Google Slides at the low end. I've found Illustrator the best compromise between power and simplicity (provided you have a license).
I wouldn't use this as a supporting argument. Didn't DSM-3 classify homosexuality as a disorder?
Perhaps not "ignored". Perhaps just "didn't follow".

Even if it would be your preferred way for a language to do things, not doing so isn't necessarily wrong.
DroneDeploy and Cloudflare Workers
“Disorder” is explicitly pejorative.

I’m not sure where I stand wrt the position that autism is just a non-inferior neurovariant, but let’s not pretend we don’t understand the difference between asserting it’s a value-neutral variant and a disease.
Excellent Framework
Parallel to the article's argument, I'd argue football (soccer) unpredictability are due to size and diversity in almost all it's aspects: most number of fans/aspiring players, also inherently (culturally) most diverse set of potential players/strategies and leagues organization.

At the regional scale, those also tend to be the most competitive and popular leagues, enabling breeding grounds of diverse playing styles. There's diversity even in how those leagues are managed and organized.

Compared to popular US sports franchises, which according to the article and my understanding (non-american), football(soccer) leagues around the world are much less centralized.

I don't know about China now, but growing up in Asia in 90s I'd say it is hard to foster the type of rivalry/diversity/competition needed to adapt to football(soccer).
I'm pretty sure that in most states so long as you remit the tax to the state, they are happy to take it, even if you didn't have to collect it. You only really get in trouble if you collect the tax from customers then pocket it.
I suspect there might be a wider market...we'll see. To keep costs down there would have to be a commercial pathway, but that'll probably mean just data center.
Thanks for jogging my memory. The only reason I mention dangerous is that fasting can in fact be very dangerous depending on a persons physiology and preexisting conditions. That said, it is much less dangerous than having T2D. So the benefits may outweigh the risks in this case.
You're taking that phrase too literally. He's saying that someone in charge of operating or maintaining something as potentially deadly as a semi truck should hold themselves to higher standards of ethics, not that there's some sort of direct correlation between weight and ethics.
Show HN: An Implementation of the Language from “Writing an Interpreter in Go”
I agree, but there's an even more compelling argument in my opinion. Government (which is basically an abstraction for "another person that isn't me") has no right to tell me what I can and can't put into my own body.
Washington State has a line item on the report for over-collected sales tax. I don't know what happens to that number, though.
My procrastination is weird. I do freelance web development (solo-solopreneur) and when I take on a contract there's no stopping me from fulfilling it. I will work on it relentlessly until it's done and there will be no urge to do anything else until it's complete. You could even say it's the opposite of procrastination.

But when it comes to doing certain things (even things that I like) I can easily talk myself into putting it off until the end of time, but once I finally get started, I usually end up engulfed in it -- at least for that day. Like last week, I wrote no joke... 8,500 words towards scripting out my next dev course in the period of about 12 hours and that was with walking about ~2 miles twice as breaks + meals, etc..
Because I see HackerNews everyday ...
I have no idea if the data support this, but it intuitively rings true for me.

My background - I failed out of college in 2003 due to clinical depression, and spent a few years getting my life together and learning how to function. I'd met my wife at 14 years old and we've been together since, which has been a huge factor in my life. Both she and I describe ourselves as "hustlers" - meaning that we pretty much always have at least one side hustle going on to generate income, and usually have several.

It as 2007 before I was really able to function as an adult and got a "real job" with an actual career path. By that time I'd been: an electrician, a photographer, a photo technician, an assistant on a dairy farm, a web designer, a PC technician, and a retail clerk. My wife had been a hair and makeup artist, a dance teacher, a graphic designer, a videographer... you get the idea.

A couple of years ago my wife was doing volunteer work as a member of our local Junior League, and the discussion turned toward career plans. Her peers in her age group (late 20s/early 30s) were in many cases either just graduating school after having achieved an advanced degree or were "paying their dues" working their first real jobs. Most of them were single and many had never had a serious relationship. That struck her as very odd - by 30, we had gone through a number of milestones for which her peers felt they still weren't prepared: careers, marriage, children, moving across the country, etc. By and large, they seemed to feel like they were finally wrapping up their education and "young adulthood", and were about to embark on their life.

I figure a lot of this was because of our backgrounds - my wife and I grew up in a poor area in Arkansas where it was extremely common to be married with children by twenty, and at the time we were living in central Virginia where the median family income was over 300% higher than where we grew up.

I do wonder though how much of it is simply generational. It seems like a lot of people I know in their twenties not only aren't yet fully responsible for themselves (financially and socially), but don't feel like they are expected to be yet. That's completely foreign to me, but it appears to be a common perspective.
March is national procrastination week.

So it is okay to procrastinate then, in observance of the event. But people don't always get around to observing it right at the beginning of March.
How I learned to stop worrying and love TDD
Experiments aren’t cheap. Patients aren’t in a good position to evaluate if a product is working or not. This is especially true when they are emotionally or personally involved in the outcome - everyone believes they are an outlier.
I read it as 10nm and thought how appropriate :)
According to a pretty charitable read of this lisence, then yes. Absolutely.
Wow, so they go to the company premises, and it's the cops that say "arrest everyone and sort it out later".

Must have been a uniquely unpleasant day for your acquaintance.

And yeah, absconding for a mere $60K is just stupid. It's not going to get you very far, except in jail. $6 or $60 million might make some sense, otoh ... (but that's for discussion under the other item on HN "everyone has his price" )
It's 200 shipments or $100k in North Dakota which would be impressive for any mom and pop eCommerce site that isn't somehow focused on ND. Almost no one lives there.
You aren't downvoted if you post serious and undisagreeable content
I've been using hacker news for about 2 years now, mostly just observing. I enjoy getting very insightful and interesting perspectives from very talented people everywhere.

Over time I'd find myself the opportunity to contribute myself on particular topics. But I found that I got shot down almost immediately with every comment I posted.

That's when I discovered this site isn't like any other social media. There are strict unspoken rules that many people here abide by.

One rule is humor. I've never seen a single comment at the top of a post that had a joke. At first this frustrated me, because I've always loved humor. I try and fit a joke or pun in pretty much everything that I can. It's how I cope with life, so it's become a part of me.

Leaving that behind was tough for me, but I understand why. I appreciate that we try to keep this place serious, because otherwise the really bright voices are drowned out, like happens so often in social media.

Another rule is explaining your reasoning. I feel that when I post about my thoughts, especially if it goes against what many others think it sinks straight to the bottom. What I've found, is that if you express the same opinion within statements that don't rant, but explain the thought process are much more successful. I still can get a lot of rebuttals, but overall the comment is not down voted, because you can't disagree with the way my brain processed something from my perspective.

I thought these things were interesting because I assumed that in order to be able to contribute here, I needed to have success in some area as a hacker. I'm just glad I can be a part of this community, and I thought it might help whoever is wants to know how to contribute in this kind of a community.

I think it's pretty great to have so many voices discussing and critiquing things together every day.
"declare jubilee on all federally-originated student debt"

So who pays for it all? I didn't use student loans, so can I have a mortgage jubilee?
What about convincing people to buy something really good?
WordPress.com Owner Buys Atavist Magazine
The 25% was just base salary.

It's TS/SCI clearance, and travel to Afghanistan with hazard pay. So, while in Afghanistan they could be making 2x as much or more.
Intel CEO Brian Krzanich Resigns Over Relationship with Employee
> Engineers are clever. Sure that might be true, but now that cleverness is going to be wasted building tax compliance solutions which aren’t even close to being “not much of a burden.

Orrrrr a couple of companies will step into this problem space, solve it, and everyone will offload their tax compliance to those companies, in exactly the same way that we don't all waste 1,000,000 engineering hours on the arcana of banking and credit card networks and just offload that concern to payment gateways with nice APIs.

This is already the way it works in most of the world. HN is showing its provincialism by convincing themselves this is some kind of impossible-to-solve problem.
No sports, still doesn't solve the biggest problem for cord cutters today (who like sports). You still have to go to at least the $35/mo plan for the sports. Which is still admittedly better than cable.
Oh, my god. Is there a browser extension or a third party website or anything out there that does this for all websites? I haven't had much luck, but that's partially because some sites have chosen to make themselves unusable without javascript enabled.

NPR, thank you for this subdomain <3
We use a YAML linter before attempting to load the file. Provides detailed feedback to the user: "Tab found at line 17, column 23"

Also detects repeated hash keys. This is a very good compromise between user-friendliness and machine-friendly specification and serialization.

Thank you very much for YAML! It is a critical user-interceptable interchange mechanism at several companies that I have worked at.
Multi-million dollar idea
Would someone please create a small car/toy with computer vision that can race around my house so my dog can chase it? I'm serious. Dog owners everywhere would buy one.

Bumping into walls and furniture would be OK if it had decent bumpers.

Upgrade 1: Have it detect the dog and stay away from it.

Upgrade 2: Make it so it can operate in in grass and stay within some boundary, or within X feet of where it started (for yards with no fences).

I think my wife and I would happily spend $200 to keep our puppy entertained and tired (we can't possibly exercise him enough!).
The US system allows you to easily pick and choose where to live, from which where you work and where you do business generally follows.

Except in the case of living close to a border (which is a bit of a hack), you generally live, work, and pay sales taxes in the same jurisdiction in which you vote and receive services.

You're right that it forces states to compete with each other, which is great.

Your example runs completely counter to your stated narrative. Your example is one in which you live and collect services in one place, but refuse to pay taxes to support your chosen lifestyle by instead "supporting" with your dollars a system you don't want to live under.

Apparently you DO have a problem with sales tax.
This is ignoring that there could be a feedback link between them. If there is a chemical imbalance that could lead to type 2, it probably does so by tricking the body to consume more. Such that the two problems could easily be linked.
I assumed it was a man because of another gender bias: I don't know many women working at Intel so statistically its likely to be a man
i also wonder about the funding mechanism and landscape.

could it be that the VC firms have come to dominate and guide the funding process in such a way that starting a firm is a lot less attractive now?
This is called "Functional testing of cognitive function" (usually something referring to trauma is added), and is an active area of study.

There are research institutions doing this to everything from fruit flies, bats, dogs to monkeys in some cases.

Hell, I even heard stories that doing it to monkeys is risky. Even smaller monkeys are smart enough to get loose, steal keys, remember access codes, cooperate, fake medical problems and they will exact revenge for what was done to cellmates. And some primates like gorillas have that, and sufficient strength to lift a small car easily.

In a way, it's even done to humans. With the caveat that researchers aren't allowed to cause the damage in a human. However a sufficient number of humans have "acquired trauma to the brain" (got shot in the head/shoot themselves in the head/otherwise manage to insert large objects into their brain and are "lucky" enough to survive), and the medical papers on that by the treating physician are disseminated and studied. Sometimes the patients are available for further testing (often they are compensated for such studies, as it leads to new treatments and even medicines). And yes, for the treatment, one of the first steps is to immobilise the head in a metal contraption. I think you can see why movements of the head are unlikely to improve matters.

Example paper in humans: https://www.ncbi.nlm.nih.gov/pubmed/16395622

Example paper in animals: https://www.ncbi.nlm.nih.gov/pubmed/29326273

Here's a non-gruesome picture of it: http://www.kurzweilai.net/images/rat-with-implant.jpg

(note that that rat still has a perforated cranial membrane with equipment keeping it perforated and will start suffering from extreme headaches in about a day, and die in weeks, from this procedure. They tend to be put down after a day or two because after that they just lie there and scream)
I have family diagnosed with ASD (all high-functioning). They're obviously different and abnormal, and they know it. In fact that specific knowledge that they're abnormal is a source of anxiety in individuals with ASD. I think it's perfectly reasonable to call it a disorder, and they seem fine with it also.
Type I diabetes is an inability of the pancreas to produce insulin. In typical type II diabetes it is not a problem of production, but rather the uptake of the insulin is inhibited. Basically the body becomes resistant to the insulin signal.
Ask HN: What is the best way to build a prospect list from scratch?
Trying to start from scratch, and build out leads for a sales team to cold call and cold email. Need to balance cost, time spent gathering, and quality of information. Leads for us are qualified HR decision makers. Every data rabbit hole I go down seems inaccurate/incomplete/etc. Where would you start for maximum results in the minimum timeframe?
> Either Koko could communicate complex thoughts, or she was just spamming nonsense and the trainers are deceiving us. That's the binary part.

That's a false dilemma.

"Either Koko could communicate complex thoughts, or she could not."

That is a binary choice. And even that is contingent on precise definitions of complex, communicate and thought.
If we're all one country, how did the President get elected when the majority of the country voted for someone else?

..and yes, I'd prefer that the ruling was that the online retailer had to get a business license in every state. That ruling would create such a torches and pitchforks situation from citizens suddenly having their lives disrupted that we'd quickly return to status quo.
Blowing up semi-random farmers on the other side of the world, those with no retaliatory strike capability, and posing no actual threat to your country? That's not defense. "The best defense is a good offense" sounds best to those who sell the missiles
> I believe student loans can be written off after 25 years. Not sure the exact details. I know med school loans can be paid off based on income and if your income is low enough (almost never happens) you don't have to pay anything.

I would frankly rather not have had 25 years of a ticking debt hanging over my head. I'd be almost 50. Maybe some people can see that far into the future and are comfortable with it, but I judged it an unacceptable risk.

Re the economies of scale, I don't think you're wrong per se, but third order effects have a lot of contributing causes.

> Also, I believe their definition of startup is not what most people on HN think of when it comes to startups. It just means newly formed businesses, the vast majority of which are small, non-VC funded businesses.

Ah, the ones where you submit a business plan and get a bank loan that you have to pay back. ;-) IMO, that's riskier than VC work; you walk away with a fat pile of debt if the biz fails before a fully formed corporate veil is established. Recall that sole owners don't have veils, as they personally sign for the debt; after a certain point of size that doesn't happen.

The ability of the median person to survive if their venture explodes is, to me, the critical point in founding a venture.

There's probably a very useful economic history of small biz/startup failure for the past 200 years. I wonder if it's been written yet!