"I'm not talking about a sterile windowless room with bright lights and various people walking in and out telling you to do things. More like a therapy setup, similar to how they're experimenting with MDMA. Someone who knows what they are doing guiding things, helping you explore your mind."

Indeed. I highly recommend reading "The Secret Chief Revealed"[1], about Leo Zeff, a pioneering psychedelic therapist. His "clinic" was not a hospital with whitewashed walls, but more like a cozy apartment (it might have even been his apartment.. I don't have the book on hand myself right now). Here's an excerpt from the book that I wrote down. It doesn't talk about the setting much, but reveals some of his approach:

"Zeff did not like to refer to psychedelics as "drugs" rather "medicine". It could be used properly or improperly, just as morphine or antibiotics. Working as a Jungian therapist Zeff believed he was there to basically assist his clients in finding their own solutions, more of less waiting it out. With LSD the solutions came much quicker, often with a single trip. In therapeutic use of LSD Zeff had his clients agree to a basic set of rules: 1. they would not leave the house or place where the trip was taking place without his permission, 2. they agreed that there would be no physical harm or violence to them, him or anyplace they were, 3. reiterate the security agreement - they must agree that they will never reveal to anybody else where and with whom they had the experience without his prior approval, 4. there would be no sex during the experience, 5. the client had to agree to follow Zeffs directions no matter what, the client had to agree to follow his commands without question and have faith in him. Prior to taking the medicine they would then read a prayer aloud. The clients were asked to bring in photographs of family and important people and places in their lives as well as personal articles which would stimulate a therapeutic conversation which would take place prior to the effects of the medicine. Once the medicine took effect the client would lie down, put a cover over their eyes and headphones on so that they could listen to music.

"Music was played the entire time during the experience. Zeff believed this to be very important. This is one area in which I wish the conversation/text had delved deeper. The music which was considered so important is barely discussed other than to say that it was always on. It is mentioned that the music would very based upon the clients tastes, the impression I get is that classical or jazz were the main genres."

Here is the beginning of a much more recent account of psychedelic therapy (I encourage reading the full article[2], as it is excellent), the methodology of which is clearly influenced either by Zeff or other early psychedelic therapy pioneers:

"When Mettes arrived at the treatment room, at First Avenue and Twenty-fifth Street, Tony Bossis and Krystallia Kalliontzi, his guides, greeted him, reviewed the day’s
plan, and, at 9 A.M., presented him with a small chalice containing the pill. None of them knew whether it contained psilocybin or the placebo. Asked to state his
intention, Mettes said that he wanted to learn to cope better with the anxiety and the fear that he felt about his cancer. As the researchers had suggested, he’d brought a
few photographs along--of Lisa and him on their wedding day, and of their dog, Arlo--and placed them around the room.

"At nine-thirty, Mettes lay down on the couch, put on the headphones and eye mask, and fell silent."

[1] - https://www.amazon.com/Secret-Chief-Revealed-Myron-Stolaroff...

[2] - https://www.newyorker.com/magazine/2015/02/09/trip-treatment