skysight-inc/HackerNews huggingface dataset:
Most of the cost is regulatory. But there is a meaningful difference between a world in which it costs $1M to screen and a world in which it costs $100k to screen. In the latter world, startups become viable with intent to find a drug candidate, rather than only being viable if they already have one. That's a big important difference, and one that was only otherwise going to be solved by everyone transitioning from small molecule to gene therapy development.
> The key argument that finite volume contains finite information seems potentially true but suspect. Case in point, take a unit square, it will have a diagonal who's digits have a long "infinite" string of digits but sqrt(2) isn't "infinite information", it's very finite (ie., one number!)

I share the suspicion you have, but I think your counter example is not valid because there is no unit square in (physical) reality. If you would try to measure the diagonal of the unit square you would at some (finite) point run into trouble with the uncertainty principle.
Why customer experience should be the main driver or your product/service
If you'd like to update the post instead of removing it altogether we can put the link back, but we've gone with the GitHub repo for now.
CCTV footage of Detroit police station Shoot-Out
I heard a story from the construction company (not int US) where my brother is working: on a construction site, they had to dig in an area with fiber. So they called the telco, aking them to disconnect the cables so they could start digging. But the telco was late and a few days later, fed up by the delay (and associated costs), the site manager said "start digging, we'll deal with the fallout". So the backhoe start digging and cut the cables. The telco were quick to send a guy after that...
Right, but the average capacity factor for natural gas plants in the US is about 56%.

https://www.eia.gov/todayinenergy/detail.php?id=25652
> It's a value because the more people you've been with the less likely you'll stay with the one you have.

a) You are conflating rape with sex. Why would being raped be the same thing, at all?

b) Everyone I've seen talk about this has been referring to charts showing increased non-marital partners correlates to divorce, but you are talking about pre-marital partners, where divorce rates actually start going down after a few partners.
> Somebody has to be keeping those stores in business?

All the adults who were deprived in childhood.
This looks like the kinda setup:

https://www.cowfishstudios.com/blog/obd-pi-raspberry-pi-disp...

Also a search for "reading OBD diagnostics with raspberry pi" brings back some promising results.
I played tennis competitively as a teen. So that was about 1 to 2 hours a day, every day in the Florida sun. Still developed myopia by the end of high school though. . .
Erm.... Idk. What was Freud then? These are certainly separate fields in terms of accreditation, but in terms of academia, they're really subdisciplines.
For technical reasons deep space missions usually run on Plutonium 238 RTGs. Pu-238 is scarce: "In 1992, the US arranged to buy 30 kg of Pu-238 from Russia for US$6M ($200K/kg). Even counting the effects of inflation, this was a real bargain, although in the end only about 20 kg was delivered." (Source: https://newatlas.com/nasa-cancels-advanced-sterling-radioiso...). More recent proposals to restart US Pu-238 production using a dedicated reactor suggest a probable price of $10-15M/Kg, meaning that a single RTG for one deep space mission will require on the order of $100M of fuel and soak up 4-8 years national production.

A further ramp-up of Pu-238 manufacturing is not inconceivable, but with PV cells that can operate usefully in Jupiter orbit, we only need Pu-238 for outer planet missions and some specialized purposes (e.g. a Mercury lander that spends a lot of time in complete darkness, or a truck-sized Mars rover).
On the topic of unsubscribing from newsletters that use MailChimp, I've had massive issues with being able to unsubscribe. It had actually gotten to the point where I was tired of clicking the button and going through the steps, and instead sent it straight to spam. It has only been some newsletters that use MailChimp. I wonder how MailChimp keeps their subscriber list and how do they let their user know if someone has 'successfully' unsubscribed.
Proof of Stake? Is That About Dracula Coin? (Explain Like I’m 5)
"you trust them with the money" -> "you trust them with THEIR money"

Why is Amazon, the corporation, with offices in 30 countries, under any obligation to help people in a city where they're headquartered, who don't work there or own shares?
Distroless images: Making small docker images even smaller
50 pushups, 50 situps, 50 bodyweight squats, and 3x1 minute planks (left, right, middle) every day followed by a shower before I go to bed.

Stretch my hamstrings every day. I, like much of HN, sit at a desk all day and my hamstrings had gotten incredibly stiff.

Earn at least 1 crown a day on duolingo.

I feel better and I sleep better.
I skimmed the paper wondering if there could be some fitness benefit for the fungus. Unless I missed it, they don't suggest any. Anyone have a guess?
This is the one feature I'm hoping to appear.
Quite cool, thanks for point it out.
Yes! I've been doing it for 3 years and I found another benefit which is improvement to my "skill" in cooking. I have a lot more intuition on cooking times, required temps for recipes, and general choice of ingredients. Doesn't sound like much but it's nice to be able to _quickly_ put together a good tasting meal
And yet thousands of women get them every day, so there must be a reason.

(Yes, they're painful. It's about 5 minutes of ripping off band-aids at 30-second intervals. Then it's over and it doesn't hurt at all any more, though the cortisone cream is soothing.)

Oh, the reason to go through that? It saves 6-8 weeks of shaving a very sensitive (and awkwardly shaped and difficult to inspect) area and dealing with 5-o'clock shadows and stubble and ingrown hairs and razor nicks. If you're self-conscious about wearing a swimsuit (or, for some, about your appearance in the bedroom), it's totally worth it.

Now, that nasty work that you're procrastinating on: why do you want it to be done in the first place?
This is similar to how when men are corced into sex then it's seen as a dream come true by a lot of people, and often many such men also feel lucky themselves. But for women it become the script of what they're and everyone feels she has been wronged.

Just due to perspective in culture one see event as achievement and other as permanent assault, even though both had same circumstances
Sure, but a packager should never be hacking the system to fix an application. That may fix your package, but could easily break everything else on the system.

The fix should have been the simple and obvious one - apply a patch that fixes the application (in this case, literally just fixing the first line of the script).
There are only 30, it's full of typos, doesn't include any finance stuff, and some aren't actually real use cases.
SignedBlock is hiring 3 Software Engineers Athens, GR/Remote

We are a company of academics and engineers offering specialised blockchain technology solutions, based in Athens, Greece. Our team offers enterprise consulting services, assisting corporations in the finance, supply-chain, insurance, and energy sectors. At SignedBlock, we also conduct cryptocurrency algorithmic trading research and develop trading strategies and algorithms in a closed invite-only setting. We build capabilities at all levels, educating management and technical personnel in understanding blockchain both at a business and managerial level as well as at an in-depth technical level.

All our positions are full-time positions in either our local office in Athens, Greece or remote. You can also combine the two and work some days remotely and some locally. To apply, send us your CV and GitHub to apply@signedblock.com.

SignedBlock is committed to Equal Employment Opportunity without regard to race, nationality, gender, disability, sexual orientation, gender identity or religion.
Reducing my portions for food, even if it's healthy stuff. I've found that it's helped me drop a considerable amount of weight yet still be able to have things I want to have, even if they're unhealthy. I started playing around with it towards the end of college and its helped me reduce food spending, intake, overall weight, and I've been shrinking dishes so the dishes I do have to do are smaller. In the vein of reducing portions, limiting certain foods to certain days of the week and committing to it has become much easier (i.e., Friday and Saturday are the only two days of the week I'll have pizza barring special occasions).

I've been trying to make exercise and working out seem positive for years now, but I don't get the rush from it that everyone else seems to. Lifting things up and down is boring, running on the treadmill or elliptical is boring, and I'm not in that kind of shape to do some kind of hyperactive training regimen. I basically just do it because sacrificing 30 mins to an hour at the gym after work and then the commute time back home is a fair trade off for not having to worry about a lot of health complications down the line.

One that I was into at my last job and that I've been trying to reintroduce is a nap after work. At my last job, I'd come home and take a nap for an hour or so, and wake up feeling like doing something. This got crushed by introducing above exercise: I'd go work out, come home and say "oh I'll take a nap", and wake up an hour or so before I had to sleep.
Indeed, I make no claim about the size of house you ought to be able to afford.

But families always have more need of space than the childless. This makes anyone contemplating children very sensitive to questions like "how much of my present after-rent income must I give up for another 100 sq ft?". And this will be very different for the guy who's found himself spending 75% (to be near google, or whatever) and the guy spending 20% (in 1958).
Stay away from CHIP, they appear to be bankrupt and/or fraudulent, they took my money and never delivered.
Great, so now in addition to paying a monthly fee for internet service and a monthly fee for the modem rental, you also have to pay a monthly fee for your router?
Last night it was baked chicken drums with simple rubs - one cajun and one provencal. Scored the chicken parts on both sides with ~1/2"/1 cm deep cuts, poured on some olive oil, rubbed in salt and some dried spice mixes we had lying around the cupboard, lay them flat on a baking sheet with aluminum foil, and baked for 1 hour at 425F. Prep <15 minutes.

There are a dozen more ways you could do this dish, including brining, marinade, other types of rub or spice, other parts, or whatever.

Optional: You can pour off some of the liquid (which can make a gravy) and/or flip the chicken near the end.
There's a guy named Ken Auer who took the life-work integration message to heart. He established a craftsmanship studio in his house. In large part, it was to integrate work, family, personal into one.

https://www.rolemodelsoftware.com/why-we-build-software-syst...

This is also why I quit the tech startup rat race and transitioned to my current lifestyle that allows me to work on the projects I am interested in, be around my family, travel when I want to travel, and go in whatever direction I am interested.

Work-life balance has always smelled of a construct created by corporate "personnel" departments to stem the tide of fleeing, burned-out workers.
I am on this side of pond, and it still sounds ridiculous to me. I don't think that someone who really wants to pay more for an imaginary taste of authenticity will not be able to read a place of production. Other consumers apparently don't care.
If those keys were generated before the company existed, and there is no explicit assignment, then they clearly belonged to him.

If they were generated later, it gets very hairy. Were they created with company resources? On company time? Is there a record of this happening? Etc etc.

Going to court would be a huge waste of money for all parties involved, at this point.
Or 70% of Nevada.

I for one welcome our paving-the-deserts-with-solar-panels robot overlords.
It's a play on op-ex vs cap-ex
Also part of the name of a fictional weapon: http://combineoverwiki.net/wiki/Gluon_Gun
It's not safe, and the FDA actually warns people against participating in combat sports or other activities potentially involving eye trauma after the particular LASIK that opens your flaps because of what you said.

Though PRK, which does not open the flap, is fine, and is the procedure athletes typically go through.
Yes! Magic indeed. I wish you good luck in keeping that habit!
Quit Facebook( which really means just access it 2mins per week on a Sunday, just because I'm on a few groups ). Close down Instafart.

Quit watching porn, after realising the health risks are not worth the benefits.

Quit buying sweets of any kind, especially sugary ones, for myself. I still buy chips for everyone when meeting with friends. I still eat sweets as long as they are made at home.
And yes, I have cheat days. So it's not perfect.

The benefits trickled down, phone usage went down etc. etc.

So I got into the habit of quitting, and seeing things for what they are.
Tesla will start rolling out its ‘full self-driving’ package in Aug, Musk says
I watched this the other day which was more informative than I'd imagined [0].

Main take away for me was to eat fibre rich foods - so instead of potatoes eat squash and celariac, instead of rice eat bulgar wheat, and so on.

[0] The Truth About Carbs: https://www.bbc.co.uk/programmes/b0b5y6c0
China’s schools are quietly using AI to mark students’ essays
Indeed, and the name was a deliberate play on the Irish word for play, "súgradh".
Almost every is a very understated way to put that.
What service doesn't let you outright buy the modem?
How the best managers find hidden tech talent
How to make a fun website
Have you come across any good tutorials or resources on making fun web designs?

I spent quite a few months this year learning how to setup a site with Jekyll and S3, which was nice to get away from Wordpress which had a lot of elements that distracted me.

Now i'm ready to sharpen the saw a bit on areas like animation, funky layout and more.
>Organic sugar isn't a panacea

I didn't say it was.

>...organic sucrose is absolutely chemically identical to non-organic.

Have any evidence to support this? Also, many things are "chemically" similar but affect the body in very different ways.
It's irrelevant whether it's an unpaid intern or the CEO. If it's published under the Microsoft brand and website, it's Microsoft's work.
Oh, no doubt heat is also not good for batteries (neither is the cold). I didn't mean to imply it wasn't.

However I'm still not sure heat is the first order effect limiting charge rates. If you consider that the charge efficiency of the cell is something around 99%, the total losses at a 1C rate relative to the thermal mass of the cell are pretty negligible ( nominally, around 3.6mW per A of charge current ). I'd wager that when your cellphone heats up under charge, that's primarily due to losses in the ~90+% efficient charger circuitry. Heat is heat, and that is still not good for the battery of course. I believe the cooling system in the Tesla is primarily for when the cells are being discharged, but it would be really interesting to hear the full story on that from a Tesla engineer.

I found the below link which also seems to imply the lithium plating as well as other chemical effects are the first order issues.
http://batteryuniversity.com/learn/article/bu_808b_what_caus...
For one, there are more candidates than capacity to run clinical trials. Costs & timelines for those have been going up over time. Lots of high-potential compounds just sitting on the shelf.
Re bread, this is one of many great reasons to make your own! It isn’t particularly hard — it takes time, but most of that time is just waiting.

The sugar in bread is rarely there for flavor. It’s a way to cut corners by feeding the yeast and causing the dough to rise faster. Leave it out and you just have to wait a bit longer, but you get a better developed flavor as a result.
Flashcards are nowhere near the same thing, or as useful.

I'm talking about cultivating your memory like a muscle. That way, when it comes time to use it, you actually can.
Most browsers these days offer a "reader mode" - great for reducing those distractions. (Also for dealing with sites with awful fonts or layouts.)
Criticisms of Marx & Freud's "social science" is basically the modern standard definition for science. I agree, as a criticism.

But... It is simply not true that psychology practices academia as a non scientific discipline. The expirement. Publish data. Etc. It is just substandard data.

Freud Oedipal complex theory may just be nonsciece but this Stanford prison "theory" is scientific, it's just scientific fraud.
I'd argue that organic can make all the difference, if the problem with sugar is the processing, not the substance.
I believe the most important element of successful remote work as a FT employee (not a contractor) is to not be forgotten.

When working on a team or working in management, so many decisions are decided outside of meetings. As a remote employee or manager, you need to go to great lengths to make yourself available at a moments notice through slack, zoom, etc.

Don't become forgotten...and then irrelevant.
Many people won't be happy if their salary would be delayed because ad network was down and website didn't generate enough income to pay expenses.
I think the issue is with the implicit claim that we don't "know" a cardinal until we know which aleph it corresponds to.
And three of the 30 are “Esssentia”
Can confirm. I walked 30 mins to work back and forth 5+ years ago every day, and I never seemed to gain weight. I felt pretty great as well. Now I have a car (and work from home, so I don't need to walk to work)...
I completely cut out carbonated drinks, I recently went to the dentist and was expecting the usual "You haven't been looking after your teeth" spiel but instead was told my teeth were in great shape. It's also been very good for my overall energy levels, I suspect that those sugar highs/crashes were worse than I had realized.
It's the same "thinking" that makes many people care more about low monthly car payments by taking out 6- or even 7-year car loans. They totally ignore how much that is actually costing them to get a new, shiny car that they really can't afford or the fact that their new car will only be worth a fraction of what they paid for it at the end of the loan. There's certainly no law preventing car dealers from taking advantage of that. Why is this different?
> Why lie to the public?

I don't, and TBH I don't find your writing style (of which this is an example) very engaging.

Cr50 is a replacement for the old TPM. It has approximately the same constraints as the Infineon TPM used in the past: firmware updateable, but not for you.

[edit to add: would a mechanism to disable the update mechanisms, at the price of "no warranty" since RMA becomes impossible be acceptable to you? Or would you suspect that there's another update mechanism anyway?]

> Pulling the battery does enable rewrite

Pulling the battery is non-trivial on a device like Pixel C, hence a new mechanism.
The Other Side of Mechanical Turk
interesting point. though this ignores the (surprisingly) successful re-purposing strategies to reduce future regulatory burden and and reduce or even eliminate high throughput screening campaigns. that well will dry up sooner or later but other discovery platforms ie phage display etc. have become commoditized and robust enough that they are pretty accessible to even low capitalized startups if finding a ligand is what you need to get off the ground.
I've heard this many times, but my experience, and those of many others I've met or read about, is that there is a substantive difference between processed and non-processed sweeteners.
Having written horrible Debian scripts for open source software that involved setting up postgres, a java package, some python websites with apache and seeing the mess I made even with the best intentions [0] I think the article is too harsh.

Whenever anyone contributes to open source our reaction should be based on love, not hate, even if they mess up. They will eventually fix it up as opposed to deciding not venturing into unknown territory anymore.

[0] https://github.com/GeoNode/geonode/blob/master/package/debia...

(Edited to fix typo and formatting)
No different than any other form of financing for other products. Take cars for example, you can lay down cash up front, or you can spend more money by paying over time. Or you can pay less money for a lease, but you lose the car after 3 years.
My dad has directv and they regularly have issues. He wasn't able to get NBA games for weeks, due to some software glitch (the entire channel was unavailable to him, for unknown reasons).
Oswald Spengler in 1923:

"And at that point, too, in Buddhist India as in Babylon, in Rome as in our own cities, a man's choice of the woman who is to be, not mother of his children as amongst peasants and primitives, but his own "companion for life", becomes a problem of mentalities. The Ibsen marriage appears, the "higher spiritual affinity" in which both parties are "free"—free, that is, as intelligences, free from the plantlike urge of the blood to continue itself, and it becomes possible for a Shaw to say "that unless Woman repudiates her womanliness, her duty to her husband, to her children, to society, to the law, and to everyone but herself, she cannot emancipate herself." The primary woman, the peasant woman, is mother. The whole vocation towards which she has yearned from childhood is included in that one word. But now emerges the Ibsen woman, the comrade, the heroine of a whole megalopolitan literature from Northern drama to Parisian novel.
Instead of children, she has soul-conflicts; marriage is a craft-art for the achievement of "mutual understanding"...

At this level all Civilizations enter upon a stage, which lasts for centuries, of appalling depopulation. The whole pyramid of cultural man vanishes. It crumbles from the summit, first the world-cities, then the provincial forms, and finally the land itself, whose best blood has incontinently poured into the towns, merely to bolster them up awhile.* At the last, only the primitive blood remains, alive, but robbed of its strongest and most promising elements.*"

https://en.wikiquote.org/wiki/Oswald_Spengler#The_Decline_of...
I still struggle as to why this is still a thing on HN after all these years. Just link to a gist if you have code you want to share that is wrapping too long.
If the Robots Come for Our Jobs, What Should the Government Do?
Me too, that sounds great. There are so many results for "quick recipes", many of which are expensive, unhealthy, or require a lot of prep.
Do you know of even a single case of a credit card company actually (not just threatening) suing a regular person? Just curious, but I think for 99% of people's credit limits it would be a -EV (poker term for "negative expected value") move on their part, especially since if the customer lost, he can just declare bankruptcy anyways, after perhaps burying a little nest egg out in the Mojave or in a child's name or whathaveyou.
I wish I could make use of those small computers better, but so far my main use case is for xbmc for my dumb TV, and I'm loving it.