skysight-inc/HackerNews huggingface dataset:
> Mark Murcko

He's on the admin / capital side of the equation and will do fine, I'm sure.

> paid competitively

That's not an endorsement and hardly an excuse. Unless things have changed dramatically in the last year or two, pay for computational / structural biologists is 1/2 to 1/3 of what a person with the same skills gets for helping build Uber for Poodles, which is in turn 1/2 to 1/3 of what a person with the same skills gets at AppleGooFaceZon or on Wall St.

The field, like many scientific fields, runs on passion, naivete, and green cards, and is quite abusive to the people doing the actual work, even though it showers adjacent concerns with money.

If science didn't suffer from such a severe value capture problem, scientists could win a seat at the table, but it does, so practicing scientists get shut out and the money goes instead to capital/risk, showmen (often "graduated" scientists themselves), lawyers, etc.
"Only" – A subtle dig ;)
You're technically right. It is not the problem of the Blockchain technology. Once something is persisted in the Blockchain you can (depending on the concrete implementation) be sure that it cannot be changed without the original owner's private key.

I feel however that the whole "Blockchain Startup Universe" always comes up with the same bullshit claims.
It usually goes like this: "Here is a difficult problem. To solve that problem we use Blockchain. The End." No one really explains how Blockchain is so much better at solving this than a regular database. But everyone just believes it is.

So far I have not heard a satisfying explanation on how anyone will securely verify that a physical object/subject is indeed this one particular hash on the Blockchain.

You will always need a third party to verify this. And then I wonder: If you need a trusted third party anyway, why do you need a Blockchain in the first place?
I think it is a result of Docker-style thinking where you can do anything because you are just preparing an image for a single application. So removing shell won't break anything.
OP mentioned a "no-name midwestern suburb" - in places like that, the main shopping street in the town often never existed in the first place. The land use goes straight from farms or ranch land to massive suburban housing developments with no functional town having ever existed in between.

Thats not how all of the US works thankfully, but in huge parts of the country which are still doing the suburban sprawl thing, its a pretty common pattern. The nearest city which existed before the 1950s might be an hour's drive away, everything is new and purpose-built by large scale commercial developers.
That seems rather rule lawyery. People in power can completely destroy your life without being "violent". The US was founded on revolt against a government that was being completely legal, so it's not like we can even try and take a moral high ground
Custom ASIC hardware for running molecular dynamics. check out Anton [1]

[1] https://en.m.wikipedia.org/wiki/Anton_(computer)
The 'unlikely anyone will' is quite likely, though, given how much more attention is given to nuclear waste compared to other highly dangerous cemicals.

Nuclear scare is the case of zero-risk bias, as by discarding nuclear people are forced to use co2-emitting methids for base load, making global warming and pollution casualties far greater then nuclear ever could. [1]

[1] https://www.statista.com/chart/13994/global-deaths-per-energ...
It's for anyone who needs to go somewhere 0.7 miles away but doesn't want to walk or get an Uber.

It's not whether it would be an issue or not, it's whether I want to carry it around.
Totally.

You know, the logical next step is a fleet of mechanical turk self-driving Segways. When the inconsiderate rider drops it off and blocks the sidewalk, just have someone take control over LTE+wide angle camera, and drive the Segway back to the nearest rental hotspot. Which could even have charging docks for the Segway to drive onto, like a Roomba.
We've tried.

In 2011, USDA tried to improve the school lunch requirements involving pizza sauce being a vegetable, but Congress blocked it all in an appropriations bill:
https://www.congress.gov/bill/112th-congress/house-bill/2112...

The USDA is now prohibited from not treating pizza sauce as a vegetable, at the behest of corporate food companies like ConAgra.

https://www.npr.org/sections/thesalt/2011/11/15/142360146/pi...
No easy money. It’s hard to find new useful materials and you have to find an area to use it in, and it’s probably expensive while doing it. It’s easier if you already have a problem to solve than finding a problem that you can solve indirectly.
Elevators are counterbalanced -- when they are going down, there is a counterweight going up. So there's less energy than you might imagine being generated.
Can't collect tax income until people live there. Can't build fire stations or bus lines where there's no room.

We've had this problem with developers as well - they want to build mega high-rise apartments with no parking whatsoever and force the city to deal with it, despite the city struggling to fill current transportation demand.
No, because bank lending is not dependent on customer deposits or bank reserves - lending occurs first, then reserve requirements are met afterwards. See for instance this research paper from Standard & Poor's:

Repeat After Me: Banks Cannot And Do Not "Lend
Out" Reserves

https://www.kreditopferhilfe.net/docs/S_and_P__Repeat_After_...
> They can't realistically need the money, since they just raised.

Keep that very same money from getting showered on a competitor? If a large chunk of money is looking for a foot on the ground in your market, opening your hands and taking it might be the only way to survive.
I mean if the USB host device itself has specialized USB hardware that can lock the ports in power only until they're fully enabled by the OS, then you'd be in a better position.

Either that or a tiny switch beside each port to enable/disable the neutering feature.
Rent Control Keeps Prices Down for Everyone
Oh, oh no. There is a missed opportunity here. Common lootboxes drop a line of code, uncommon an entire method, rare, a full object, and legendary are working samples.
There are a number of chips in the phone running their own OSes that you have no control over.
Rackspace uses a bunch of abandoned mall space, as I recall.
Google doc with some information:
https://docs.google.com/document/d/1WmOMKq63Rap2wfQ-yy7sHyoc...
Figuring out ownership of robots is interesting.
I don't believe in the physical reality of real numbers, but that doesn't detract from the their extreme usefulness as an abstraction. For that matter the negative numbers don't really exist. Nor do fractions or zero. They're all just convenient because they do a great job modeling situations we care about in a consistent way. Or at least consistently enough for everyday needs.

It was a bit of a mind bender initially coming to this conclusion, but shrug.
For when you need it only for OBD-II, this might be a better/cheaper option: https://www.ebay.com/itm/OEM-Bluetooth-Mini-ELM327-V2-1-OBD-... (it connects to your phone via bluetooth, it needs no external power and there's a bunch of apps on the Play store that you can use).
Hi Vapemaster and others,

Currently doing some research on the industry and curious if you could link to some of the "dead bodies"? Also curious if you know how Verseon's model (https://www.verseon.com/) stacks up versus some of the others mentioned? Obviously it might be hard to say since all their drugs are currently in the pre-clinical trial phase but would appreciate any info you might have.

Thanks in advance
if you wanna know how freedom of speech in EU is gonna like in 2 years, just look at China. 5 years? Kim is nodding at you
This looks very similar to Vuepress.

https://vuepress.vuejs.org
Even if blockchain DNS systems were production quality - which they're far from - why is a 'central authority' inherently bad? The entirety of cloud computing, and the modern internet, is based on the pretense of giving your entire infrastructure to a centralized authority. "Oh, but what if your centralized cloud provider is actually evil and incompetent", the free markets allow you to change providers until you have a provider with absolute highest quality.
Where does math impostor syndrome come from?
Uber Lite: Built in India, Designed for the World
Gitlab working document https://docs.google.com/document/d/1WmOMKq63Rap2wfQ-yy7sHyoc...
There has been sudden glut of articles about scooter startups here on HN and elsewhere. And I am scratching my head trying to understand what exactly is the end game plan here? If self driving cars and Uber etc succeed then all commuting will be through cars, how will these scooters fit in that picture?
Gitlab Postgres Issues
I initially started off with Headspace, and once I became comfortable enough, I started using a countdown timer on my mobile device for arbitrary number of minutes (swings between 5-15 depending on my capacity for the day) and started doing it by myself.

I look at Headspace like more of a water-wing for beginners than a tool for serious meditation.
“I think moats are lame,” Musk told analysts on Tesla’s first-quarter earnings call Wednesday. “They are like nice in a sort of quaint, vestigial way. If your only defense against invading armies is a moat, you will not last long. What matters is the pace of innovation, that is the fundamental determinant of competitiveness.”
There no technical reason for it to be that high. Perhaps I should reach out to them.
My understanding of economics is that capital and love are inputs to the productivity formula, but don’t raise it.

There are lots of externalities (pollution) that are hard to measure.
60 seconds in the case of iplayer for the fa cup. 1m20 in the case of BBC News channel right now. HLS tends to be packetised in something like 15 second chunks at the end of the process.

I know why there's a delay, I'm just amazed that people aren't concerned about it. The BBC used to offer multicast sources of live TV, which is a far more sensible solution, far more bandwidth efficient and allows end-to-end transmission in the satellite (or even less) range.

Wowza did a talk at demuxed last year about how to do "3 second latency end to end at scale", which I found amusing given that TV people have been doing sub millisecond latency at scale for nearly 100 years, so at least some people in the industry recognize the problem (which is mainly for sports events)
The scale of the Universe
In the comments the author says, "Blockchain is amazing technology - but it is a solution in search of a problem." That's really the tl;dr of this article. Blockchain has a lot of potential value but arbitrarily throwing it at problems won't magically create the value (not counting investors blindly throwing money at buzzwords).
>> why isn't there more of a focus on material science?

There is. A huge example of one that has a lot of crossover is battery and energy storage technology, which at its core, is material science.

3d printing is more popular now than ever before and continues to rise in popularity. SpaceX prints their SuperDraco rocket engine entirely out of Inconel [0], which is a good example of a major breakthrough in material science.

The "scientists" you seek often wear welding aprons, face shields, and are creating stuff. The material science revolution is what we call the "Maker" revolution.

[0]: https://en.wikipedia.org/wiki/Inconel
I've dabbled a bit with digital sculpting, and for me, Blender's sculpting tools feel really odd. I haven't tried out Dilay, but both ZBrush and 3D-Coat's sculpting tools are a more natural fit for me. Blender has a certain inaccuracy I can't articulate very well that makes it hard for me to use effectively
Ya right. I have wasted many years of my life dealing with Debian/Ubuntu audio packaging.

Here's the 20 step process for the layman if audio doesn't work -
https://help.ubuntu.com/community/SoundTroubleshootingProced...

God help you if you are building enterprise software that requires that audio stack across a hundred different sound cards. Never had any such problem on Windows.
I started this two months ago, too. My motto is "Showing up is the victory."

Once I'm in there, I give it my best. Some days my best sucks. I don't worry about that. I got my ass into the gym. It's the habit that matters.

It's about consistently showing up.

For context, I'm 34 and clinically considered morbidly obese. My relationship with exercise, like virtually all obese people, is one of yo-yo diets and countless failed attempts at getting fit. I never before lasted more than a few weeks.

A big part of the problem, I came to realize, was being too results-oriented. I'd be highly motivated those first couple weeks when the pounds seem to drop so quickly, then lose all motivation when the weight loss slowed down to a healthier rate. Then I'd get depressed, quit, and binge eat until I reached a new low of physical fitness and self-esteem, and start over.

This time around, I just get my ass to the gym. That's it. I don't care what the scale says. I do try to eat better, but I don't beat myself up about it when I fail -- because beating myself up just causes me to binge some more. I just pick myself back up and hit the gym the next morning.

Here are some results so far:

1) I've discovered I actually LIKE lifting weights. So I do mostly that. I look forward to the feeling of my limbs being like jelly. It feels like accomplishment. To be clear, I've never, ever liked any form of exercise before. By changing my focus to "just show up", I've freed myself to find something I like, rather than trying to keep up with anyone else.

2) I've been tracking my weight, and after an initial loss of 25 pounds I've put back on another 10. But, my waist line has gone down 3 belt notches, so I try not to take the number on the scale too seriously. Sometimes it's up, sometimes it's down.

3) My focus at work is through the roof. I just feel better. Less sluggish. Able to concentrate more, which is mega important as a programmer (preaching to the choir, I'm sure).

4) I sleep better and wake up on time without much of a hitch most of the time. I'm still not super chipper first thing in the morning, but I don't hit snooze either.

5) I have more energy to give to the people I love, i.e. my kids and my partner. I'm still not superman, but I'm not sitting on the couch begging to be left alone either. I play. I do stuff.

6) I just plain like myself more.
With this and GDPR the EU is seemingly begging to be cordoned off from the broader internet.
Aching muscles means you do something right. Don't shortcut yourself. I like ATHLEAN-X on YouTube. He has a lot of advice on how to do full reps and how to hold your body for maximum gains.

Note that the 7 minute apps have just 30 seconds per exercise and a few seconds between them to adjust your posture. I like it that most are just using your body. And yes, just push-ups can be challenging. For people, who don't think so, try a close grip or one hand push-ups.

I'm also 186cm. I went down from over 82kg to now a bit over 75kg. I'd like to stay there and just get further lean.

Oh yeah, I do it everyday. Use a streak future so you don't skip a day. Try to get a longer streak than your friend or brother if that motivates you!
Yes, I confirm the same. They are both returning server 500 errors. That is quite a coincidence.
Interesting thanks! How do you get your engineer's public keys uploaded to the ldap server? Do they generate keys themselves and upload to some portal?

Also what makes you distrust teleport -- is it just third party code? I think you can (or have to) self host it but maybe that's not true for enterprise.
Finland tends to have very restrictive zoning, but they still managed to turn old public hospital stone throw away from city center to startup office space (https://maria.io/). I'm sure there are some local governments where they don't want something like that (likely with attitude similar to "we don't want any changes"), but generally speaking things that bring jobs & capital are very welcome almost everywhere.
They hit a big setback here in Nashville. People are leaving these things all over the place. The city is looking to regulate these types of devices. Please, Bird, don't pull another Uber. This is not an existing market to be disrupted. Work with the municipalities to get a working framework in place so we will all be better off.
Fostering a web performance culture
What's up with the vinegar? Just for flavor?
You're saying it's preposterous that people use coded language to affect racist policy goals in order to avoid political backlash for anti-social beliefs? Really, that's preposterous?
In 80s 100 reactors were in planning and the price was lower then a coal plant.

Many of those are still running and they are safe.

Understanding why the cost has gone up 10x can not be explained simply by 'slightly higher security regulation'.

Something else went wrong in the whole process and the regulated utility market.

> If you think there is going to be some magical world where people get rid of safety regulations for nuclear power, after the Fukushima nuclear accident I think you need to reconsider.

Nobody wants to 'get rid' of safety regulation. However talk to any expert on nuclear energy and you will see that the current way to to regulation is highly ineffective and damages the industry.
The Magician of Meat: How Pat LaFrieda Reinvented the Burger
There is. It's just that materials science is a bona fide Hard Problem that requires tens and hundreds of millions of dollars in lab equipment (synchrotrons, free electron lasers, the good stuff), supercomputers etc. to advance, so it's studied by top universities, National Labs and so forth. It's not really something you can "disrupt".
All the eggs in one basket.
There is something to be said about kicking someone when they're down, and finish them off. Democrats had the votes, they should have made it a law. But both parties do like to play the regulation pendulum swing game. This is not the Democrats' first day at the rodeo, they knew full well this had a good chance of swinging the other way with a Republican administration. And so here we are.
Uptime on broadcast is different because it's not on demand. The reason people use Netflix is because on demand is better than broadcast, because broadcast has implicit uptime issues. Anytime that I cannot watch something on broadcast television is downtime, not only that, but it is unrecoverable downtime. There is no comparison to a service whose downtime functionally compares to the latter's "commercial break.
1) Do malls exist in Europe?

2) If yes, are they also failing?
it happens, but its rare. I've been doing this for a year and no way I'm going back.
Since that server is very slow in USA, here's a mirror: https://www.docdroid.net/i1zITmK/evidence-for-biological-sha...
First four words are enough for me.
A fine read ... a piece that teaches us so much about the human side of things that matter in engineering management.
The four lobby groups!
That difference is due to a systematic change in how arXiv generates URLs for submissions, starting a few years ago. No arXiv submissions today will have a URL with a category. Articles (each with a unique arXiv id YYMM.xxxxx) can have multiple topic tags; the article under discussion has two tags, one of which is "quant-ph". Cranky articles which cannot be refuted on technical grounds are often found on the "general" topic tags.

As an aside, since the above comment is essentially trying to infer the quality of the paper from metadata, it might be worth knowing that the author is a well-regarded quantum physicist with many highly cited papers.
Wages have to stagnate for a whole long time for our 200k+ salaries to lose their value.

I'll worry about that in 10 years if that happens. Plenty of time.
> Are you saying that individual Swiss banks are currently free to make up their own reserve requirements?

No, but bank lending is not made from customer deposits or bank reserves - lending occurs first, then reserve requirements are met afterwards. See for instance this research paper from Standard & Poor's:

Repeat After Me: Banks Cannot And Do Not "Lend Out" Reserves

https://www.kreditopferhilfe.net/docs/S_and_P__Repeat_After_...
Anybody building a colo facility in Antigua?

old: https://www.wired.co.uk/article/antigua-legitimate-piracy
>The key argument that finite volume contains finite information seems potentially true but suspect.

Look into the Bekenstein Bound and maybe the Pauli Exclusion Principle. A finite volume of space certainly does have a finite limit to the amount of information (physical information, quantum states and the like) it can contain.
Bit drastic considering this was their first major global outage...
You can't switch ICANN... Unless you count onion addresses but then Namecoin is very similar.
>In my career lifetime as a software engineer, I worked for five different companies in my career lifetime. These jobs lasted from 3 months to 2 years, with a few periods of no work in between, also lasting anywhere from a few months to a few years.

It sounds like your employment history might be a little bit streaky. Nothing that is insurmountable, but it might be worth having someone look at your resume you are portraying your experience in the best light possible.

>What things can I do for my peers that would help out the situation? I have the experience, but none of my colleagues really comes forward to me to ask me if I'm looking for work. I'm always the first one to ask.

Maybe buy them a beer or just tell them that you are looking. At this point they either trust you and want to help or they don't. The time to build those relationships are before you need them. This doesn't mean that you need to be best pals, but at this point you just have to ask and see if they will help you out. Most people like to pay it forward so you'll be surprised how much help is out there.
Perhaps because a small part of the cost of the product comes from the sticky stuff itself. Selling a quarter of the quantity may have 90% of the cost of sale. So it might have to be $12 for a pack or, $11 for a small sachet, to be worthwhile.
Vue Native
You-drive cars haven't replaced you-drive scooters. Why would self-drive cars replace them? Sometimes you want to be out in the fresh air, they're cheaper than a car to rent/maintain, and they can get places cars can't.
Thanks will give it a try.
I have yet to come across any problems that are solved better with a blockchain than with any other traditional technology - except for the original one, a distributed electronic currency.
If anybody can provide an alternative source for the text thanks in advance. It requires a google login for reading.
That just seems like an unnecessarily negative perspective to me. The point is, we are starting to de-carbonize the economy. And it's being done because market forces are a tailwind, not a headwind.

All the moral imperatives in the world won't be as effective as a profit motive. I'm not one of those silly people who finds a moral valence in market forces, but I'm always happy when I see them working in my favor, because they're as relentless as erosion.
> https://outage.report/stackoverflow
Wegman's attracts a pretty affluent type of shopper, doesn't it? The one in Taunton has Round One, a massive bowling alley/billiards area/video game arcade/karaoke center as its anchor. Which is a lot of fun but probably would have been considered an undesirable tenant a while ago (although I guess in Natick you guys did have Game Underground for a while).

The Taunton mall is actually kind of fun. The run-down nature means that there are funky little stores you wouldn't see in a more upscale mall. But on the other hand it's also half-shuttered.