skysight-inc/HackerNews huggingface dataset:
Epigenetics is not "how the genome is read" -- you're describing the normal action of transcription factors.

Epigenetics is heritable information that is not encoded in DNA base sequence. Common mechanisms include DNA methylation patterns, histone binding patterns, and histone modifications, all of which can be stably inherited from one cell division to the next, but not necessarily transgenerationally, from parent to offspring, through the germ line.

You are also confused about turtle sex determination. The master regulator of sex determination (which must respond directly to temperature) is unknown. The epigenetic regulator KDM6B is required to mediate the temperature signal for male development, but there is no evidence that it is the master regulator. Maybe you read a press release instead of the actual paper in Science.

Environmental sex determination is not that unusual, and need not depend on epigenetics or even transcription factors.
You might be able to trace the execution of the iterative code more easily, but in my experience it is often much less clear why that produces the correct result and how that code was written in the first place.

Take a look at the wikipedia page for computing Levenshtein distance: https://en.wikipedia.org/wiki/Levenshtein_distance#Computing...

The recursive version needs barely any explanation. But ask me to carry it out by hand and I'm sure I'll pretty quickly get lost. The iterative version needs a lot more explanation for why it is the way it is, but I also think I could carry it out on paper quite easily.
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I'm currently trying to switch from Eclipse to vim: to ease the transition I'm using gvim.
One difficulty with vim is that you have to configure it because by default it's pretty dumb..
This is exactly the recipe I used and sold a company for $10m. Also, I am a absolutely terrible programmer and v1 of the product, with which this recipe was executed, was full of copy pasted code, unhashed passwords, all of the hallmarks of terrible programming. I got to $100,000 revenue before a friend of mine joined who actually knew how to program and rewrote the whole thing (literally zero lines of my original code were preserved).
They waited until 10 days before flyby to upload a shit ton of code?

@_@
I think it solves the major issues with docked scooters/bikes which is the infrastructure cost of installing the large docking stations which increases the rollout costs. This artificially creates a monopoly on bike sharing in a given city. It also limits the number of stations that can cost effectively exist.
Some. It's proportional to level of effort. Good luck to you if their APIs are broken and you need engineering to fix it.

Co-sponsored events (as in conferences) + AdWords 360 + Attribution 360 + high 8-digits/year spent on AdWords and another high 8 spent on YouTube isn't enough to get that sometimes.
In the 2000s, I was a happy customer of BT Ireland when they provided residential broadband to customers in the South (unfortunately, when Vodafone took over, the quality degraded drastically within weeks). If an Irish ISP provided IPv6 to residents of the Republic, it would be a big incentive for me to switch providers.
It's neither stupid, nor indicative of a "malformed world view". It denotes the aspects of masculinity which are toxic. You can't even pretend to tell me that's the empty set.

You're absolutely right there's toxicity everywhere. To infer from the presence of toxicity in a given domain — say, "masculinity" — that the phrase "toxic masculinity" somehow means "all masculinity is toxic" is, I submit, more reflective of your worldview than it is of the term's legitimate users' views.
No, very far from it
> It's rare that I come across comments about China that are legitimately racist on HN

Perhaps your threshold has a different set-point from mine (and from people who are the target of similar comments). I include conscious and unconscious bias, and Chinese people are just as capable of anti-China racism as women are capable of being sexist.*

The same people who criticize the Chinese government for not allowing Facebook and Google to operate in China (even after Cambridge Analytica) will defend not allowing Huawei to be sold by carriers in the U.S. The same people who, when it is pointed out that Foxconn's suicide rate is lower than the population average, will say that any non-zero number is too high. Do they change their tune if it's pointed out that Foxconn is a Taiwanese company and not a Mainland one? You know the type -- in a later breath, they will just as easily say that Chinese people can't / won't innovate, and can only copy.

There was a story in Sheryl Sandberg's _Lean In_ about an experiment where 2 resumes were being considered for a police chief: one candidate had more solid work experience, and the other had more impressive education history. The 2 experimental conditions assigned a male or a female name to each resume, and most subjects (including female participants) chose the male resume, and they'd say it was because of work experience or education that they picked it. If your threshold for sexism includes that, and you adjust your racism threshold similarly, you'll find that a lot of comments have this ... _unconscious bias_ for some reason.

* Criticism of what the Cultural Revolution has produced does not fall under the same umbrella. No one likes what it produced, even the leadership currently in power in China, who suffered in their youth.

Edit: comment in threads down below include ">his stupid uneducated bimbo of a wife" in reference to China's first lady. Here's what CNN has to say about her:

"Peng is arguably more famous than her husband. She has millions of fans... She is a major general in the People's Liberation Army and is China's AIDS ambassador to the United Nations."
http://news.blogs.cnn.com/2011/01/20/thursdays-intriguing-pe...
yeah if someone slips on your property and gets hurt, you're looking at millions potentially

But a $600+ billion dollar company that steals millions of dollars from thousands of publishers? $11 million . It's as if they measured it down to the penny exactly which is rare because often you see these huge settlement numbers like for tobacco companies, where it seems excessive. But the case where there are the most victims and the most hurt victims and victims that are the most innocent gets the most pathetic, most measured payout. It's the exact opposite of the frivolous lawsuit.
Yes, but only up to a certain point. Larger semiprimes are still a pita to get the primes out of.
"While we don’t know the deal USPS crafted with Amazon, we know it’s not losing money. A 2006 law codified profitability into law, and an independent regulatory commission that reviews their deals annually gave it a green light on March 29.

That said, it’s possible that the Postal Service could be charging Amazon more for package delivery and therefore get a better deal. That still doesn’t mean USPS is losing a fortune.

We rate this claim False."

http://www.politifact.com/truth-o-meter/statements/2018/apr/...
We shouldn't assume we know all mechanisms, true. I do believe I've read of RNA changes retained over generations but could be wrong about that.
Exactly. I've been a C, C++, and java developer for the past 12 years and never used Big-O for anything other than a shibboleth to get past the door. A couple places practically used C++ itself as a gatekeeper: they want people who are smart enough to program in C++ and survive it's rigorous interview process, but their main product is filling out forms and routing documents through a document management system.
That’s not really as effective though. Sometimes you need to be an asshole to get your point across. Civility will make you look like a weakling and you will be continually passed on promotions.
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> You need to re-read my comment, especially the sentence after the one you partially quoted.

You're not fooling anyone when you say that you're not accusing people of being propagandists, but rather that they're just "perhaps like" them.

> Anyway, you are not acting like a stable, sensible person. You're getting too worked up.

Says the guy whose two month old account has 75% of its comments about one topic, but nice try. I also wonder if you are subconsciously channeling some tactics from the past:

https://en.wikipedia.org/wiki/Political_abuse_of_psychiatry_...

EDIT: And of course, recalling Cato, I will end by nothing that you still have not responded to anything I've said but rather have devolved to calling people who disagree with you crazy. Gee, it's almost like you're just trying to divide people instead of actually trying to have a good faith discussion.
well dang! :-)
There are chemical means of removing methylation. Early days, and you basically get the equivalent of a disk wipe, I gather.
The only really interesting part is finding and keeping OS bugs secret. I wonder how many more the NSA is sitting on?
The vast majority of books I noticed at my local bookshop were dedicated to different openings or certain subcategories of those openings. Batsford, I think, is the most famous publisher of these.
Is this using Unicorn, Puma or something else?
You're assuming rich and high IQ go together. We don't live in a meritocratic society and as such, that's not true.
Authentication for the decentralized web
This happened to me as well, virtually the same story.
This appear to use a Cyclone FPGA from Intel, which was previously Altera: https://www.altera.com/

It will be interesting to see how this compares to some of the existing designs based around the Lattice ICE40. The Lattice FPGA programming information was reverse engineered and this triggered a lot of interest around the open source toolchain and many boards were designed around this FPGA:

http://www.clifford.at/icestorm/

https://www.tindie.com/products/Folknology/blackice-ii/

http://icoboard.org/

https://www.olimex.com/Products/FPGA/iCE40/iCE40HX1K-EVB/

https://blackmesalabs.wordpress.com/2017/02/07/icezero-fpga-...

https://www.crowdsupply.com/qwerty-embedded-design/beaglewir...
Your idea about food brought to mind the food deserts that are common in many cities, where the only places people can get to to buy food are convenience stores that have little to no fresh produce.

How might people be able to pool their resources so that they could bring more produce into the neighborhood? Or even so that one person who is able to visit a further supermarket could bring back produce for a few neighbors who can't, and be assured of being reimbursed?

That's actually a small part of a larger issue around transportation, too. There are many cities in the US where people who don't have cars (can't afford them in the first place; broke down and can't afford repairs; etc.) are utterly cut off from opportunity. Some walk several miles each way to get to and from school or work. Those who are physically disabled or simply not in excellent physical condition are entirely cut off from opportunity.

What about software that helps people ride share not in the sense of "anyone can be a cab driver and work for Uber/Lyft", but in the sense of carpooling; maybe with the carpoolers covering the driver's fuel costs or otherwise contributing a small amount of money (far less than the cost of a cab or Uber) so that everyone wins?
More of a marketing phrase than a code of conduct. Google realizes the sham is up so there is no use pretending anymore.
This is definitely something everyone has been waiting for.

The only question I have is.. why? One generally hopes that everyone is out to do no evil, including those that do so unintentionally.

So why remove something that's been so closely associated with the company for so long? Did some executive find it "tacky"?

At any rate, this is truly a loss for the internet.
Two big problems with docked remain with “pseudodocked” — 1) need to get approval to eliminate a parking space and 2) users have to walk a bit at the start and/or end of the journey.
Many AP English classes teach Byron. Many an English teacher loves a hater like Byron
Inside the telephone exchange for the universe
For those of you who don't need the newer features of Shoes 4, there's the "green shoes" [1] version of the project, which only needs GTK and doesn't need Java. You just need to do "gem install green_shoes" and "require 'green_shoes'" and you're good to go. I've used green shoes for a bunch of simple utilities :)

[1]: http://ashbb.github.io/green_shoes/
Reminds me of one of Microsoft's first Dynamic HTML demos:

There were two buttons, one labeled "Our Web Site", the other labeled "Our Competitor's Web Site".

When you moved the mouse over the "Our Competitor's Web Site" button, it would quickly slide out from under your cursor before you could click it!

Then when you stopped moving your mouse, the "Our Web Site" button would slyly slide right underneath your mouse!

Dammit Microsoft!!! ;)
How heavy use of social media is linked to mental illness
I've done a fair amount of interviews in my professional career, both as an engineer at Google as well as for my own startup.

In an eng. interview you want to maximize information divided by time, i.e. you want to learn as much as possible about whether the candidate would be a good fit for the company and spend as little time as possible doing so (because you have other things to do -- such as interviewing more candidates).

In my experience these kind of interview questions have a very poor information by time ratio. They are poor on information because they may give you an idea how well the candidate can do on puzzle questions but not so much how the candidate would do on actual real-world assignments. And they are especially poor on the denominator (time) because you are probably going to spend at least 1h with the candidate before you get past the obvious stuff.

Also I guess about 70% of (pre-qualified) candidates would outright fail the question, so if you let this influence your hiring decision, given that the question is really quite "puzzly", you're inevitably going to miss out on a lot of talent (the kind that does well on actual work assignments).
Crap you're right, I don't know why GitHub would present a link and the content is missing...

I'm sure I have a copy but this should be the source. I'm actually on the Shoes maintainer list, so if nobody knows why, I know who to ask at the least...

This link got me there

https://www.google.com/url?sa=t&source=web&rct=j&url=http://...

http://evc-cit.info/cit020/nks.pdf
Another counter-point. I and everyone I've talked to love the idea. I mostly commute by my own bike, and generally prefer walking for most errands or short trips. The scooters are an easy (and fun!) way to make short trips more practical especially when I don't want to deal with trying to secure a bike in SF.

Of course there are serious issues to be worked out and there will be growing pains. I'm particularly concerned about the number of riders (scooters and e-bikes alike) without helmets, as well as the influx of people who are finally realizing that they don't have to take a car everywhere they want to go learning to navigate a crowded urban area (and a bike lane/sidewalk!) for the first time.
No, I meant the readability in .json file. Should I care for that anyway?

Also, great website! :D
Mine was terminated before that, and to this day I can't open an adsense account, even with a site that gets a million views per year.
Agreed, following the SV mantra of work under the radar to prove the business model until the cities legislate a la Uber/Airbnb, this makes sense (and seems to be the path chosen). The paid dedicated scooter parking zones would be the fallback option if the city puts forth a plan to outright ban dockless scooters or the scooter companies want to start playing nicely proactively.

"In the ideal scenario you're proposing, we should just get rid of some street parking to make room for other uses. Let's start cutting down on the massive amount of money we spend subsidizing car ownership."

>> Yup agree - maybe start putting car parking meters up where there is free car parking and use that money to repaint some of the spots for dockless bikes/scooter parking zones!
Talent allows some people get away with being jerks. If you think talent and bad behavior go hand in hand, you should meet some new talented people.
Again I'm bad at chess but that sounds like mostly a waste of time until you're already very good from what i understand. That stuff might be entertaining to learn but if you're rated like 1500 I doubt you're losing cause your oponents are getting out of the opening with a 1/4 pawn advantage. And it takes a lot of study to get to the point where you worry about that (imo)
Some publishers lost over $1 million I think. After the fees and lawyer cut, I don't think much will be left. The $11 million is a reduced figure. The initial figure probably was enough to cover all payouts and fees.
PayPal does have options now (actually, they've had them I think for a decade at this point) to support straight up credit and debit card processing for customers who don't have PayPal accounts.
https://www.youtube.com/watch?v=_fHfgU8oMSo
3/3:

Impossible, you say? Well, we all do it on a daily basis. In deep sleep. And maybe that's the key to the craving of silence. For we find deep sleep very restful, and we crave it during our wakefulness as well.

I am just contemplating here, typing in real time -- have experience with meditation, and extrapolating it vis a vis the article at hand. I have kinda learnt to "sleep" while being awake and aware. The trick is to let the perceptions come and be, but not do any "work" with them. No interpretation, no labeling, no drawing of boundaries around objects. When thoughts arise, just automatically forget them, not even remembering that they arose. It can be quite restful and rejuvenating; perhaps because it is a silence of sorts.

[Edit: N/N => 3/3]
But is that something she will like ?
Interesting that Steve Jobs was not a fan. Didn’t the original iPod use a physical pie menu?

Edit : oh man, totally misunderstood the distinction. I’ve axtually never thought about these menus before... but now after this post I saw one within five minutes in Fortnite!
It was this or manipulating all search results for "evil".
Nonetheless, even though it's highly embarrassing to the parties involved, with a little bit of self-deprecating humor if I was the doctor, I could tell people at parties that I, along with Newton and Leibnitz have been published on a foundational numerical integration method. ^_^
Still, it's the opposite of what you'd want. Instead of those people asking if you could help them, you have to go out and find forums where people might need your help. Imagine that doctors had to find patients like that. In fact, perhaps I should start a consultation hour for people in need of IT solutions.
I'd recommend Kim Zetter's book on this subject: https://amzn.to/2rQUGnq
If you try both the vive and the rift you'll see that the default for the rift is fake hands that mimic yours. It's cool but I personnally couldnt get fooled. I prefer the vive controllers.
Fun fact: if you google “git blame” it returns his wikipedia entry.
I agree it was more of a marketing phrase. The code of conduct is more likely something like "Only do evil if it makes good money and don't get caught."
I mean if you label all your variables i,j, and k and use minimal formatting or bracketing then I see your point it is harder to read. Whats complicated about an iteration. If it works properly after the first one chances are it will continue to work for the millionth one. If you see problems, its because something is modifying it between runs, but that wasn't a fault of the iterative strategy, it was the fault of a bad programmer.
Conversely, you must always make sure the stopping condition and all base cases are met during recursion. Forget one corner base case and you got a rare production bug.
one possibility is the refund is done to create the illusion click fraud is being prevented . It's like a manager telling the owner only $100 was taken from the til but $150 was and he pockets the $50. Not that I'm saying google is like that but you have no way of auditing this figure.
Child malnutrition can be substantially mitigated with those peanutbutter balls.
Yes, these are valid concerns.
1) I don't know how to encrypt logs and send them. If you can help please open a PR on GitHub or walk me through it :)

2) How else should I store it? Should I encrypt the json file with a master key?

3) This is correct but I just wanted a quick way to do it :) Thanks for the concerns.
Map editing is an excellent application of pie menus, to save you the many trips back and forth between a tool pallet.

When working on the SimCity user interface, whenever I considered popping up a window or dialog on top of the map, I thought about how many acres of prime real-estate I was covering up and hiding from the user. Or how many miles I was forcing the user to move their mouse back and forth between the map and the toolbar. ;)
I've heard both of those stories from multiple places. I don't know exactly how you'd define "technical," he clearly wasn't a strong engineer, but I have heard multiple examples of him managing technical things. I remember around the same time he was known for memorizing chips and vendors very very well that he could source them very cheaply.

I think a good firsthand example is a one hour q&a with developers he did in 1997 soon after returning to Apple:
https://www.youtube.com/watch?v=yQ16_YxLbB8

He doesn't necessarily show off deep technical knowledge, but he is able to discuss strategy about technology directly with developers. Managing technology is his competitive advantage.
Must one have something to live for? I expect it's pretty common not to know, and to keep going from day to day driven by base animal instinct to survive. Many of the common answers are just rationalizations.
So many stories of people who had their account terminated.
The GDP, the consumer spending market and the consumer spending per household is all higher in the US than the EU. You can cherry pick out a few industries where other countries spend more than the US, but it's still the most valuable market by far in most industries.
More examples of things like pie menus

- Messagease that I've been using since Palm Pilot days http://www.exideas.com/ME/index.php) is pie-menu-like

- Inspired by pie menus and Messagease, I experimented with a touch-screen native calculator (instead of skeuomorphic) back in the Maemo days: https://wiki.maemo.org/Ejpi

cross-posting from reddit: https://www.reddit.com/r/programming/comments/8k9ylk/pie_men...
Interesting thought - maybe, there is a cure. Bear with me now, but isn't the main problem here the fact that massive ego builds a wall between you and other opinions? If so, there is a whole group of substances that do exactly the opposite - promote closeness to peers and temporary suppress ego.
I'm guessing they're not happy about the whole drone assassination debate going on internally. It's so disadvantageous that their staff can call the leadership outright hypocrites based on their own professed values. This makes everything so much easier for everyone.

Information on the drone program: https://theintercept.com/drone-papers/

Google's complicity in Project Maven: https://www.defense.gov/News/Article/Article/1254719/project...

Google's Internal Debate: https://www.bloomberg.com/news/articles/2018-05-14/inside-go...