skysight-inc/HackerNews huggingface dataset:
It is funny what does and does not catch the attention of the popular science press. This really isn't all that important as an example of research. It is a very incremental increment in exploring the connections related to cellular housekeeping and stress responses. There really isn't anything that can be done with this knowledge that couldn't be done already with the existing knowledge of the ribosome.

This is an example of the broad, dominant class of aging research that is purely investigative. Most research into the detailed mechanisms of degenerative aging is very far removed from any thought of application, and it is lucky happenstance when such an opportunity does arise.

Unfortunately, systems very closely tied to cellular housekeeping, or responses to stress, or replication seem unlikely to result in the foundations of truly effective therapies. We can look at calorie restriction or exercise, both of which alter all of the above items quite profoundly and throughout the body, to see the plausible benefits that might be attained through manipulation of these fundamental aspect of cellular behavior. We can also look at the past fifteen years of research into these mechanisms to see just how slow and expensive it is to try to produce therapies to slow aging - there is very little to show for all of the effort invested.

Searching for means to adjust metabolism to modestly slow aging is not a winning strategy; the expected benefits are just not large enough. We must find ways to add decades of vigorous life, not just a few few healthy years.
By the time its descendant Firefox came out, it was a much safer, stable, standards-conformant browser. Still have memories of just how complacent MS got when IE6 was released.
Well, I didn't study senescence but actually did do something similar.

It required training myself in math, programming, history of the topic, and stats in addition to the normal grad school stuff (memorizing stuff for classes, data collection, etc) which amounted to about 3 years of working almost nonstop.

Turns out nobody cared, all they wanted to know is if there was a significant difference between groups. My attempt caused me health, financial, and social problems for literally an anti-reward so I would not recommend anyone try it. I also don't believe anyone would get a nobel prize for that in the current environment, they would be ignored or fought against because some holy cows would need to be sacrificed.

EDIT:
As a more concrete example. Look at the pushback against Tomasetti & Vogelstein for daring to point out that there is a base rate of mutations per cell division and accumulated mutations lead to cancer, so cancers arise more often in tissues with more divisions. This is almost common sense, but people cannot handle it for some reason:
https://www.theatlantic.com/science/archive/2017/03/no-cance...
Take the same music, invert phase, add to original: sound recovered. Very loud white noise would be a lot more effective.
If you're trying to minimize the pain of waking up, a better bet is probably the watch alarms that identify gaps in REM sleep.
Compare this to free public transit in some European cities
Have you tried weight lifting? I hate pretty much all rote cardio but I have been lifting for almost 10 years now. Since it is low reps, you don't get that progressive burning. Plus, it is cool to see progression as you get bigger and stronger over time.
do let me know if I'm missing any good shortcut to put.
data alone is kinda worthless. time + granular data is valuable.
Found this great Marc Andreessen keynote from the Netscape Developer Conference in 1996. Netscape wanted to be everything simultaneously. Youtube, Slack, Gmail, Amazon, AWS, Dropbox and about a dozen other businesses. Wonder if they just focused on one product. Say "groupware for Fortune 500 intranets". They would have increased chance of survivability. Even considering Win98 bundling its competing offering in their OS ;)

https://www.youtube.com/watch?v=e8wdc9qkkV4
A major reason, unfortunately, is that they don't want to be interfering with the distribution of scientific articles. For example, if there's a very well-read journal in a specific discipline, but whose contents are only visible with a subscription, then if one countries prevents its researchers from publishing in those journals, research by that country's researchers will be less read. And the reason they do not want to do that, is because they by all means want to avoid being able to suppress the reach of research whose conclusions they might not like, to prevent situations like when the Catholic church was able to do so.

(That is, if they are actually actively aware of and see it as a problem. Lots of governments/funders also don't have an active Open Access policy, although this is starting to change.)
You can try to grab it for you with a net or something.
For content-based buffer opening, I use fzf's Tags command - it fuzzy searches ctags and open the file containing the definition.
Our Aquatic Universe
Especially considering you can fly Orlando to Miami, possibly in less total time.

Granted, flying is not a cost effective means to commute, but I don’t think rail service from Orlando to Miami will have too many true commuters on board compared to less frequent travelers.
Google’s “customer service” policies have always been trash.

IMO it’s a part of the culture there that will never change. Good reminder to switch as many services as possible from Google before something irreversible happens to our entire company and all of our personal email accounts / domains.
It’s not a rule but an observation. We can certainly become more self-aware and change our behavior.

Munger’s Psychology of human misjudgment, for instance, is enlightening:
https://youtu.be/pqzcCfUglws
Cheaper RAM and faster cpu, bloated software and lazy programmers.
Getting product strategy right
TeaCode 1.0 for Mac Released. Write your code super fast
Understanding Deadlocks in MySQL and PostgreSQL
Some laws should be ignored; it's how the law system improves. A law that is obeyed by everyone will never be changed, because the opportunity cost is not made visible.
Take rock music, played by a $0.20 shitty chinese speaker. Indistinguishable from white noise.
First measurement of subatomic particle's mechanical property
> our IT guys were trying to get a hold of Google but couldn't get in touch with anyone.

Try your legal team, if your badly-run company has one (I am not a lawyer). lol
That’s the same excuse that’s trotted out in every field with a piracy problem—up until someone finds a way to do it and it turns out it wasn’t an insurmountable problem after all. That’s how we got iTunes, Spotify, Steam, Netflix, and so on.
Because the hjkl key bindings are invented by touch typists for touch typists.

Touch typists are more comfortable with using hjkl than the arrow keys as the hjkl keys reside in the home row; so they are extremely cheaper to press than the arrow keys for touch typists.

And, you don't need to move the cursor in insert mode. vim and more generally the modal editing concept is invented just so you don't do that. I'm not sure if you are a rookie vim user or have a niche use case that requires moving the cursor in the insert mode.

I think it is funny that vim supports arrow keys at all. It's probably to reach a wider audience, and for compatibility. And a related fact is that the original vi doesn't support using arrow keys in insert mode in the way you expect.
The Line Between Big Tech and Defense Work
It’s not free though. So figure out how much of your tax goes towards public transportation and _then_ compare.
The main point of this article is mostly misguided, IMO. The real one is that you don't know which tech innovation will have a great impact before hand.

Most of the things that has big impacts are actually things we skip through. For example, we have a pretty decent camera in our pockets at all times. We take pictures constantly. The "selfie" revolution, one that has big impacts in how we perceive ourselves and want other to perceive us is enabled by having an small quality camera around. At some point passing from "terrible quality" to "good enough quality" made a jump in that.
Sure, not everyone takes selfies. But it has been a big change in photography in the last 10 years or so. So big we have a new name for something it exist before.

I'm pretty sure that being able to track a run and share it on social networks is a big motivator to do exercise, for example.

I seems weird to me talking to AI, and even weirder that "the future" is calling to a shop with an AI instead of using some sort of web shop/app/whatever to get an appointment.

But who knows...
Really great tool. Using it every day!
Definitely check it out
NPR, Where Are the Landing Pages for Podcast Episodes?
I bought their software. The software stopped working properly and nagged me to buy a subscription - despite having purchased the full product previously.

I lost my interest in being their customer. They did offer my a 1yr subscription for free, but by then I had wasted hours trying to get a new install to work and had lost my goodwill with the product.
Really excited to see YC Bio longevity startups when they launch.
Any incidents where Google terminated the paid account? No longer a paying customer at that point.
> The TLAs have fairly healthy cultures

Weren't the CIA caught red handed spying on congress?
It's disgusting how bad its gotten. It's assuredly partially nostalgia, but I think also partially truth, but the internet of my younger years I remember as being filled with labors of love, pasionately created content most places you look. Now it's difficult to find much that isn't lowest common denominator pandering or essentially white noise.
Is Elixir being used extensively outside Silicon Valley? Can you list some well known success stories? Looking at job listings and open source projects, it doesn’t seem to be widely used. In fact, I don’t know anyone outside Silican Valley who has built anything non-trivial in Elixir.

I am not saying it is bad. But I’d like to know about it before I dive in.
For those interested in Internet history, there's a very interesting roundtable discussion hosted by Walt Mossberg with Steve Case, Marc Andreessen and Brad Silverberg at: https://www.wsj.com/public/current/summaries/hyperoun.htm.

If you scroll to the question: "Brad -- you seem much less interested than Marc or Steve in the prospect for non-PC hardware to access the Internet. Can you really make the PC simple enough and cheap enough to make it a ubiquitous access device?

Brad's response seems to foreshadow Microsoft's notorious mobile device strategy for the forthcoming decade leading up to the release of the iPhone: "...Given the choice of a Web appliance with a sub-optimal Web experience (because by definition it can't do everything a PC can) or a PC that gives the best Web experience, plays games, runs productivity applications and everything else you can do with a PC, we think the overwhelming majority of customers will continue to choose the PC. If the Web appliance is a 10x opportunity relative to the PC, Netscape's investments certainly don't match their rhetoric. Finally, everyone is in favor of the subsidy model, but no one has agreed to actually spend their own money to subsidize devices...."
The best tip i had when using vim is to almost never actually use h or l.

w and b are faster because they move you horizontally between words, so pressing w 5 times will get you to the fifth "word" on a line, and b will go backwards. You only really ever use h or l after getting to the "word" you want, then going over to a letter using h and l.

I still mostly use j and k to move up or down lines
Quantum Physics May Be Even Spookier Than You Think
Sure it does, ART was AOT only during Android 5 and 6.

Android 7 brought the VM back.

Now it uses an interpreter hand written in Assembly that gathers PGO info for the JIT, which also performs PGO data gathering, then only the hot bits are AOT compiled to native code, when the device is idle.

Any change on the execution path or updates trigger the execution process from the beginning.
People are risk averse; predictable expenses are easier to plan around than unpredictable ones. What if you're unlucky and it breaks twice in a year? Or the first repair is bungled and you have to go to a different shop, and argue the first one into giving you your money back?
the site is down so I don't know how many miles his commute is.

but what if he factored in riding a bicycle when it isn't raining (into work) and using Uber on days when it's raining in the mornings?
> Every now and again, at some huge auditorium, a senior staff member at one of the big firms based in northern California – ordinarily a man...

Absolutely irrelevant to the topic. I already ignore the hype, but I think I'll also ignore this author's hyperbole.
Ahh, classic MacOS. Those were the days. I once locked the entire system so hard neither mouse nor keyboard responded.

(14 year old me had opened the System file with ResEdit. Turns out opening a System menu resource for editing while it was in use was a really bad idea).

First proper computer. Learned a lot with it.
How to Subvert Democracy: Montesinos in Peru
I thought that was Bloke 101. Actually, the hardest part is getting the lugnuts off. When your tyres were fitted, they likely used air tools to put the nuts back on. I’ve found you always need to ensure you can remove them with the spare hand tool later - otherwise you may end up with a flat somewhere and be unable to remove the wheel.
I once read a memorable analogy for European explorers "discovering" Africa:

It's like (today or 18th century, does not matter) some African dude showing up in the middle of a busy European city center yelling "I discovered Europe!"

I fear I've mangled the analogy, in the original it also was pretty clear what was meant, of course the explorer discovered it from a European perspective. The original storyline included the self-important and presumptuous attitude of the Europeans that made it seem like there was nothing there of any consequence or sophistication.

Another story was about the African drums [0], ow they actually work, that saying "drums talking" was not a figure of speech, but that that actually was exactly what they were doing! The drumming follows some aspects of how you would actually speak the words (the languages are tonal), "The pitch of the drum is varied to mimic the tone patterns of speech". Since lots of information is lost most words are ambiguous, they compensate by embedding every word in a context, saying (drumming) longer phrases instead of one word for disambiguation. And they could just talk over long distances relaying information faster than anything the Europeans had at the time (like semaphores).

[0] https://en.wikipedia.org/wiki/Talking_drum
You need more information on why you need to constantly start services, and why there are long running queries.

The latter is actually one of the easiest problems to find a solution for. If your problem was too many concurrent transactions/high load, then that would involve distributed solutions. But slow queries? That is solvable with less work.
The New Passport Poor
Truly an awful line of reasoning. To add a little substance to that comment per HN guidelines: they could be being investigated now, the gov may not have caught up with their illegality yet, etc. etc. etc.
Who was waking up the knocker ups?
It was a better browser. It’s fashionable to hate on IE6 these days but it was the first browser fast, stable and feature-rich (XmlHttpRequest) for serious use. That’s why it became so ubiquitous and hard to unseat.
It's nothing out of pocket though. And that's the point. Also your argument cuts both ways. The US as a whole subsidizes car ownership to a huge degree. Do you want to factor that in too?
The Android world only has to loose by dropping compatibility with Java libraries written in Java 9 and newer versions.

Or do you think now everyone is going to rewrite their Java libraries into Kotlin, using JVM 8 only features?
> And that would mean that a younger generation of scientists would have to wait much longer before their ideas could be discussed without opposition from the established elders who see their pet theories attacked by these uppity youngsters.

Okay I will accept that premise for the sake of the argument even though I don't actually believe it's true.

Based on that you go on to conclude it's a good thing that scientists die, so that science can keep advancing.

You're essentially faced with a trolley problem, where pulling the lever one way will make everyone immortal at the cost of slowing down scientific progress, but pulling it the other way will euthanize everyone in the world, and euthanize the countless billions that might live in the future. Somehow your morals (or whatever you call it) tell you that euthanizing everyone is better than slowing down scientific progress. I disagree with you there.

Why not even try to solve the problem some other way than killing everyone? I don't know, why not, say, create an off-world colony outside the reach of those evil progress-impeding elders. Just throwing ideas out there.

Taking your logic to its limit, why not just kill every scientist after their first paper is published? But I don't think you actually want that, so lets hear your argument against my strawman.
I've heard of the practice of knockerups several times before but always they used a rod of some sort. The title is misleading as it reports plurally but the story states that Mary Smith was unusual in singularly using a pea-shooter and only reports on her, and later - on her demise - her daughter Mary, using a pea-shooter [possibly the self-same one?].
They can hold up really well. However you’ll find that generally the economy of a newer car is staggeringly better.
Ionic can get you the most code sharing. Ionic uses a web view to render the UI so it will never get you the same as a native UI, but it is actually really good. Expect a few delays here and there, though. Make sure to try it out on the oldest phone you plan on supporting to see if you’re okay with the performance before moving forward. Ionic will get you the most code sharing.

React Native is a great for cross platform iOS and Android native. If you want code sharing across native app and web app, look into ReactXP, or come up with your own code sharing technique, which apparently @sdcookie’s team did.

Titanium from Appcelerator also supposedly targets Native and Web.

Also consider focusing your efforts on native and not doing a web app. RobinHood stock trading app went a long ways without having a web app. Just throwing that out there.
Can we? We've built the system to replace it have seen it transition into widespread use. However, it turns out that there are strong emotional ties to the old system and few want to let it go.
For what value of "last several"? Honestly, I'm not at this point sure whether I read any Byron in high school English. I have the impression that he was very popular in the US curriculum until the modernists devalued the romantics.
Not entirely sure about that, they have very extreme driver turnover and are constantly offering very expensive incentives to drivers.

I wouldn't be surprised if they are somewhat profitable in established markets but I'm not sure if it's 'healthy'.
You should consider your target audience and your own resources. For consumer facing apps, I'm not sure an hybrid (cordova / ionic / webview shell) approach is really up to par, as the UX is really challenging to make right and performance will be lacking. That said, a native approach requires twice the codebase and twice the resources (man hours) roughly, so the challenge becomes maintaining feature parity and team expenses.

Apps targeted for B2B users are considerably more flexible in terms of UX, the goal is mainly to help users get stuff done, so hybrid is more viable here. Which is what we usually do with cordova. Some considerations to bear: using cordova, the team doesn't really get much expertise with the proper platform, so problems are sometimes harder to debug because of lack of developer maturity in the platform. You need to design with an eye to light performance requirements, which usually means facilitating inputs and maybe have a separate web interface for complex UI like dashboard and management.

If you absolutely have to share code between apps, your options are:

- hybrid approaches like cordova, or build your own native web view shell and load your web code manually

- react native, which is not v1 yet, and looking at it recently I'm personally not sold on it yet, many unkown unknowns to actually double down and build on it. But that's just my opinion.

- Black box compatibility frameworks like Xamarim, Nativescript and the like. They work by giving a common platform middleware that builds to multiple target platforms. There are a lot of trade offs here, specially the lack of control. If a feature is buggy or not supported there is little recourse.

- I have read some big companies share code via C++ bindings used natively on each platform (loaded in Java and Objective C). I imagine this technically "solves" the problem, as you can share code and build natively, though I have no idea what tooling there is to help with this, and imagine the developer experience gets the short end of the stick.

edit: typos
The comments here seem to focus on the specific examples, but this misses the point of the article, which I take to be that _every_ new product or feature, no matter how minor or how incremental, is treated as the second coming of the 100x engineer and the cheering crowds hand-picked to promote whatever they see aren't helping by covering it rabidly.

He's not wrong, but I've heard that complaint about the tech press in general for years, so I'm not sure its bringing anything new to the table on HN.

But at the same time, "some of these will surely turn out to be revolutionary eventually" isn't a great excuse to treat everything as revolutionary before it has a chance to even be seen in the field.
Trump eliminates national cyber-coordinator job, gives Bolton keys to the cybers
Same here. I studied for an EE degree in a very demanding university. Learning exclusively from books proved to be more effective.

> Most people are not like this, they need the structure, they need the help.

Only because they've been educated to be passive learners!

For centuries, aristocrats could afford large family libraries and were very self-directed in their studies. Today we expect scholars and researchers to be avid readers and able to find their own sources.

There is no evidence that the remaining 95% is born without the ability to learn from books. (No, IQ is not very relevant here.)
don't know why you are getting downvoted, this is exactly what people are saying. all someone has to do is google "brightline train criticism" or "brightline train deaths". there are tons of stories backing up your claims.
The enduring mythology of the whiz kid
Why Engage in Proxy War? A State’s Perspective
Ask HN: What are some college courses run and taught solely by students?
Such as https://github.com/RPISEC/MBE
It's quite a bit cheaper than that per-mile for the existing segment. Not sure where the above poster got "30 miles" from, since there are already 70 miles of track in service (Miami-W. Palm Beach). The $1.5 billion figure is for upgrades to the entire existing Miami-Cocoa corridor, which is 200 miles, so about $7.5m per mile in upgrades. Another $1.5b is budgeted to construct the new 40-mile line from Cocoa to Orlando, so that'll be $37.5m/mile for the new-construction portion if that comes in on-budget (remains to be seen).
Had the same thing in Brighton. Uber was quoting £90, taxi stand was £48.
I don't think the vast majority of 60 minutes viewers would have been aware about any of the details mentioned in this piece. Not everybody follows Google anti-trust chatter.