skysight-inc/HackerNews huggingface dataset:
Elizabeth Rosner isn’t a biologist, and (unintentionally, I’m sure) misrepresents the research. The majority view in the field of epigenetics is that trans-generational epigenetic inheritance of things like trauma currently lacks compelling evidence and, just as importantly, a plausible mechanism. The studies from Emory University and Mount Sinai, for instance, were widely panned (see article) for lack of controls, lack of mechanistic insight, and weak statistical analysis.

What little evidence there exists shows a very narrow range of effect in model animals. I’ve co-authored one such study that specifically shows the heritability of stress in mice. I can confidently say that this only works in very specific, artificially constrained instances, the evidence is tenuous, and mechanisms are elusive.

To clarify, this isn’t to say that trans-generational epigenetic inheritance doesn’t exist. Rather, we know that it does in specific circumstances (in particular in invertebrate models). But the claims by Rosner and in some of the more sensational (and flawed) papers require a big leap of faith that most scientists in the field aren’t willing to take, lacking evidence and a mechanistic explanation.

What’s more, none of the scenarios described by Rosner requires trans-generational epigenetic inheritance. It’s much easier explained by social/cultural transmission. Invoking epigenetics in this context is pseudoscience.
Edit: of course universities are tax excempt, so why do we care at all?
> Let's please at least take a moment to appreciate what's been gained for humanity as a whole

The ability to interact faster? It’s a big wash: positive and negative.

It’s hard to see the internet as objectively good for humanity.
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You got old.
Yeah, to be clear, I wasn’t saying it’s definitely the wrong choice for all library code, or anything so strong. More like, it’s worth considering the case your users will be using, since for several of them it is likely not the right choice.

For dense matrix multiplication it’s probably worth it, but the article is phrased much more broadly in its conclusions, and does not mention the fact that this issue exists (possibly because the author isn’t aware of it — which I don’t fault them for).

To be clear, a 2ms stall when calling certain functions has the potential to be devastating for anything that wants to run at speeds approximating realtime.
We recently started to purchase Ryzen 2700 for our office, and us used to be all Intel 4790K and Intel 7700K. These AMD CPUs are pretty great price for what you get and way faster than the similarly priced Intel CPUs for our needs.

We sort of make fun of the multi-colored CPU coolers that come with the CPU though. It seems weird to have these in business machines.

(We have also invested in another 16 AMD Threadrippers, they are just amazing power for the price. It is sort of weird that is less than 6 months, we have become an AMD shop after being Intel for as long as I can remember.)
He is clearly referring to the guys charging 50k / year to 19 years old.
> using npm or bundler simply feels sane

I feel the opposite. Lock files are awesome when your developing a package, but after you release it, you are at the mercy of all your dependencies in making sure that they don't break semvar. Each "npm install" will ignore any lock file your package was using during development.

It would be awesome if I could distribute a package-json.lock file with my npm package and have yarn/npm use it when resolving packages on fresh installations.

Yeah, this would mean that there may be duplicated libraries in your node_modules tree, each with a slightly different version, even if semver compat. However, people break semver to often anyway.

I want to deploy a package to npm and be sure that it will never break, ever.
> I feel like the decline of traditional television is behind a lot of the push to destroy net neutrality.

It's the decline of TV, news and traditional media in general. Look at what the news industry has been able to do against social media/tech companies. Brow beat them into serving as spammers for their own news content so that news companies can make more money. The same thing is happening with TV. Youtube is now spamming traditional tv content at the expense of regular youtube content. I used to get variety of recommendations from programming to sports to "trending comedy". Now I get recommendations for things I've never watched on youtube - John Oliver, Late Night Shows, Saturday Night Live, CNN, etc.

They couldn't compete in the new internet/social media environment, so traditional media is forcing the environment to change for them. It's been working for them in the short term, but will it work in the long term? I hope not, but who knows.

The changes have been incremental, but people truly don't understand how much google search, youtube, reddit, facebook, etc has changed in the last 4 years.

The internet/social media has gone from local/non-traditional media content to predominantly corporate content. And it's a trend that's going to accelerate as tech/social media is pushed to favor corporate content over ordinary user content.
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A single position could easily represent the bulk of what this article reports. The article generalizes this far too broadly.
I really hope they improve also tab sync - for some reason it usually doesn't work (or better yet it works but I see tabs from months ago, which is quite useless)
hmm, they will develop more intelligent systems which will have applications in all domains.
Even Alan Turing have done some biology-related work: https://en.wikipedia.org/wiki/The_Chemical_Basis_of_Morphoge...
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Or VPNs. :)
I'd like to make a complaint that Meatspace is inaccessible for n00bs and amputee character classes. Also, higher level characters seem to be stopping new players from leveling up.
Check out the sed and awk tutorials here: http://www.grymoire.com/Unix/Sed.html

sed in particular is really amazing in what it can do, very simply. (Note, depending on your system, you might want to get GNU sed, for "extended" regex support.)

Those pages do a great job breaking down the basic behavior and explaining pitfalls. They're skim-able, and pretty easily searchable after than, so you can come back and remind yourself of the thing you learned last week.
https://jakdojade.pl/ - city travel planning site.

Very clear info about privacy plus list of c.a. 100 'trusted partners' that they share info with and you can disable each and every one at any time.
nice, you could do something similar using direnv[1]

[1]: https://direnv.net/
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I came across this list of GDPR compliance statements just recently: https://track.siftery.com/gdpr-checker
Visual changes are an easy feather-in-the-cap for both front-end developers and for management. A design overhaul is immediately obvious to everyone. It's something you can show off. It's something you can add eye-candy to. Changes like that are more glamorous than performance improvements. People that are trying to justify their position love to attach their name to those types of things.
Excellent book. Although it says 2015 in the title it's still actively being worked on.
In the G4 days you could do that through authorized distributors who would sell you the boards directly as “replacement parts”. It was completely possible to build your own beige box Mac running on a real Apple board.
That's annoying when jumping between apps, but it does in no way prevent your from running an alternate browser of your choice for 99% of your browsing needs.

Yes, having to copy-paste URLs from Safari to Firefox sometimes is cumbersome, but it's a million times better than having to use Safari as my main browser.
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Your presumption is wrong. Science has shown repeatedly now that your assumption about carcinogens in marijuana is incorrect (I'd describe it as a "zeroth-order hypothesis", simply imputing properties by superficial similarity but no other evidence).

In fact, with the except of one non-invasive prostate cancer, marijuana seems to have a protective effect against lung cancer.

It still does cause respiratory health problems in heavy smokers, but not nearly as significant as tobacco smoking.
Hmm, the problem was not that paper bags inherently kill trees, it was that virgin forest was being destroyed and not replanted in order to make paper products. So the obvious solution of using sustainable forest growth and recycling was rejected (however, maybe by "The Market" - aka refusing to accept responsibility for externalities) presumably because plastics were marginally cheaper.

Market forces just don't work for these things because the negative consequences are decades away and don't necessarily affect the producers/consumers at all.

Your position that people who didn't want rainforest destroying for one-time use bags are responsible for one-time use plastics is way off the mark. Such people use reusable bags from sustainable sources invariably, for example.

When these issues hit the mainstream, and the public don't fully understand the position, then it's easy for the Capitalists to shift to the 'next-worst most profitable' thing rather than shifting to a sustainable production.
I thought that was entertaining before I learned biology, but after knowing more it's far less entertaining.

They didn't know a map of the cat, they knew a map of mammals. Evolution is really cool that way. Also perhaps it was easy to catch up because it wasn't that much knowledge.
Baked goods also contain acrylamide and probably cause very small increase in rates of cancer. Not worth it from a health perspective.
My mistake. I should have replied to "then they shouldn't buy OS X".
Yes this is fair, I just havent seen any occasions where this was necessary.

You usually have a senior person (or a few) that knows everything and calls the shots anyway.

Heck, even when I had to pick up the pieces of a mess, I found the code easy enough to pick up.

Btw I think frameworks are a far bigger deal than a language. Languages look similar enough and it seems like the biggest challenge is using libraries.
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Some of it I honestly feel a lot of it is more the deep commercialization of the Internet, frankly. A lot of modern "commercialization" has involved "clickbait" that is designed to produce some sort of emotion (often outrage at frankly incorrect information). This goes beyond the adverts -- a fair bit of Youtube entertainment feels like cheap stunts chasing clicks to me, reminding me more of the type of tactics reality TV engages in than anything else.

The Internet of the 2000s was more about blogs (eg Livejournal) and forums (like Something Awful, Fark, etc.). A lot of these were not solely advertiser-driven businesses (LJ and SA in particular relied on premium features for revenue from what I recall) and maybe that's a key difference. True, maybe some of it was because "we were young" -- I am in the same age group. But I dunno -- there was a time when I used Facebook quite a bit as well. This is no longer the case. Yet I'm still on a few obscure phpBB forums that seem quite fine to me.
I was 16 when I first read Spinoza's Ethics. I didn't understand much by then, what I did though radically changed my conception of the world. It's not an easy philosophy. It creates havoc in our conception of human society. No free-will, thus no sin nor merit, for example.

Spinoza is also a great philosopher for people not used to the "canonical" philosophical methodology. The treaty looks and works like a formal mathematical proof with definitions, axioms, and propositions systematically proved by pure logic.
This is a non-issue, and the people writing about it are either A. Trying to smear the subject of the article B. ignorant.
>Seeing how badly a 'hegemony of the aged' cements in most places in the world in the form of wealth and political power

I don't see the problem here with age. The problem you're describing seems to stem from other social issues, namely nepotism, classism, etc. People living longer isn't going to change that much I suspect; people have had these issues for thousands of years, and if anything, it's much better now than it was centuries ago. There's far more social mobility now than there was in Medieval times.

>Just go to you local city council planning meeting and see how gray haired and crazy the NIMBYs are

I think I already addressed that: age has an effect on the brain, so if we figure out biological immortality, we should also figure out along with that how to eliminate these aging-related problems/diseases.

The other problem you describe there is basically classism, and the ability of locals who gain power to shut others out of power. Again, this was much worse in the past when people didn't live nearly as long. The way to fix it isn't to have people die off early, it's to come up with laws and policies that counteract it.

The way to fix the NIMBYism problem is simple, and they've done something like this in Japan: you remove power from local government to set zoning policy. Obviously, local governments get people like this in power who don't look out for the overall good of society, and instead look to maximize their real estate value through manipulation of zoning, so you strip them of that power and move it to the state or national level. In the Bay Area, this means the state government needs to grow a pair and pass some strict laws about zoning, and severely curtail the ability of local governments to reject development.
starts at 400k? where do you get that number? I can imagine a director 3 type position, which would be true for most fields. But interviewing, talking with recruiters, and looking at salaries on glass door, facebook pays a median 130k. Amazon pays closer to the 100k side with a maximum of 165k, an absolute ceiling that shall not be passed. There is stock, but even being equal to base, still no where near a starting 400k
Not quite. I could say "I support colonizing mars" and "I support the colonization of mars" and those both mean the same thing, don't they? I'm not actively participating in either of those acts, am I?

I think a lot of it is implicit and context based. And maybe it's even based on personal interpretation, but even in your examples, I see those two sentences meaning the same thing.
It's still around, and lately there's actually new stuff on it.
some radio stuff here that may or may not be of interest FWIW: https://meanderful.blogspot.com/2017/05/lines-radios-and-cab...
I think this is a Pocket premium feature, no idea what their plans are regarding bookmarks and Pocket.
Historically this has been a little tricky to add due to some peculiarities with addons. That shouldn’t be an issue anymore, although I don’t think anybody’s jumping at implementing the bug, presumably since it seems like it will require walking on eggshells to avoid upsetting search contracts (for example, it becomes tricky when you consider that search contracts are by location but users could have devices in multiple locations. There are several other headaches around this too).

We do sync bookmark keywords FWIW, which can be used as a sort of search, but it’s a bit indiscoverable and not the same as syncing settings like your default search engine.

(I work on firefox sync)
They are durable, very durable, compared to vinyl and latex. But they're not some kind of exotic metamaterial; eventually something will tear them open, and car internals can be rough environments. The much-thicker mechanics' gloves are more durable for a lot of that stuff, but they really limit you because of their thickness.
If only youtube makeup tutorials were so easy...
You see old and crusty, users see a stable software API that receives security updates for decades.
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It’s highly unlikely that Amazon (or anyone) can reliably find or build datacenter space that is high quality _and_ within a few miles of other such space across all the regions they operate. If they had gone to to such lengths they would clearly state that zones are fully independent from each other. Instead they only say that about regions.[0] So even though I have worked at neither company I’m going to say their concept of a zone is mostly equivalent — independent in terms of power and network domains but in the same building or at most on the same property. This allows them to have the low latency that is touted between zones of a specific region.

[0] https://docs.aws.amazon.com/AWSEC2/latest/UserGuide/using-re...
"I support the division..." and "I support dividing..." both indicate support for the act of dividing, whether you have the authority of decide on whether or not the division is happening.

If I'm at a birthday party and there's one piece of cake left but three people still hungry, I could say "I support the division of the piece of cake" or "I support dividing the piece of cake" even if the person celebrating the birthday is the ultimate authority on whether we will divide the cake. I'd convey the same idea, just with slightly different words, and likely different intonation, too.
It shouldn’t unless your device is unable to sync for some reason. You may have error logs in one of your firefoxes at about:sync-log. Either way it’s probably worth either filing a bug or asking in #sync in mozilla IRC.
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I detail the more-or-less complete timeline here:

https://threadreaderapp.com/thread/980789585801351168.html
You don't recycle plastics in your country?

A problem in the UK has been that plastics have been passed on for recycling only to be sent to China, for example, and dumped.

The issue as I see it is that we expect waste processing to be profitable and only do it if it is - waste processing should be handled from the profits of waste production.

So many companies conning their customers with half-empty packaging, products designed to break, etc., seems to be a large part of the problem.
> licensing macOS to PC users

Never gonna happen. Mac's are very secure, performant and polished exactly because Apple controls its hardware. Done right because they can. Amen :)
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Hebrew, not English.

But yes, it would be interesting how this compares between languages. I feel like this is a common pattern in many languages though.

EDIT: another angle could be social status: some might perceive this negatively as bureaucrat speak or phony?
This is true at the surface level. However, biological systems are organized by principles. Source: degrees in both fields.

Memorizing large numbers of facts give way to understanding and intuition in my experience.
It’s quite similar to how a chess player’s experience regarding strategy starts out by exhaustively enumerating potential futures and eventually turns into an intuitive understanding of future plays and how training a neural network leads to a high dimensional manifold representation of a concept.
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>Biology is immeasurably harder than physics

Statements of this form are essentially always false: basically everything has the same difficulty because the standards for what constitutes progress in a field are set according to what the people working in it can do on average.

It's easy to write down what you thought of Infinite Jest, but in order to achieve any special success as a critic you're going to have to beat out everybody else that's doing the same thing. That makes it very hard. Likewise in an alternate universe where physics was easy, the standards for how much you had to say in a paper would rise until the average paper was about as substantial as it is now.
I spent about 30 minutes reading, but I didnt understand why this has 140 points and is the top thread.

Can anyone explain?
I would appreciate Intel NUC-style box with GPU equipped Ryzen Pro. I know about NUCs with Intel CPU and Vega M GPU but they seem to be too expensive.
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A straw man question. That's not the problem with which.

* https://github.com/koalaman/shellcheck/wiki/SC2230

* https://unix.stackexchange.com/questions/85249/
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As a counter example I am a fan of this website design. It's nice, readable and does not distract.
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To me it sounds like Tequila
In the past I've suggested that these string prefixes be made user-definable. I was just starting out learning programming for serious back then (which I never really did BTW), as a uni dropout, so that was a bit stupidly audacious of me maybe. But I still think that this is what Python should do. Because the way things are, they keep changing the syntax all the time and they have nothing like Perl's "use v..." syntax, which can cause problems like a script written for python 3.n can fail with a _syntax error_ when run with an interpreter 3.(n-1), and that _is_ a fiasco, compared to an error like "AttributeError: type object 'str' has no attribute '__prefix_f__'". I guess same goes with the "@" operator, this sort of things are what major versions are for.
Wow, thanks! I'll have to check this out.
I was referring to deploying one's own application.

Obviously, anyone can screw up anything, so the fact that an application installation won't work on a particular OS instance/version can very well be an issue with the application, and not the OS. But, that's basically my point: it's okay if the application screws something up, but the OS should present consistent and backward-compatible APIs for application binaries, and any application-specific libraries should be bundled with the application and installed into application or user-specific locations.

You mention DLL hell: this really stopped being an issue in Windows XP because of two things:

1) MS made it so that you cannot very easily drop DLLs into system directories anymore, and strongly discouraged anyone from doing so going forward.

2) MS made an effort to add features like assemblies to allow versioning, etc. to be used in the case where you absolutely, positively needed to do the above:

https://msdn.microsoft.com/en-us/library/windows/desktop/aa3...

However, almost no one besides MS uses assemblies (.NET uses them extensively) because they're complicated to manage and they're not necessary (this is the lesson that Docker advocates are not learning). Global, shared user libraries are a feature for a past that no longer exists where disk space was at a premium.

Linux distributions need to a) figure out what a standard Linux API consists of, and b) make the changes necessary to keep these standard APIs in place across all distributions (with backward-compatibility). The browser vendors were able to do this pretty well, and JS in the browser wouldn't work at all without it.

Finally, my motivation here isn't to bash Linux because "yay Windows !", rather it's my frustration of watching this go on year after year with Linux, each year hoping that this kind of thing would get resolved and that I might be able to start targeting Linux wholesale. I just cannot understand why this is not a priority...
Your comment gave a better and much shorter explanation of what Fuse is than the blog post did, and confirmed for me that it's not related to the identically-named filesystem tool. Thanks for the explanation :)