skysight-inc/HackerNews huggingface dataset:
> Well, at least with plant medicines we have thousands of years of safe human use.

Wow, that's the most obvious argumentum ad antiquitatem I read this year.

"For thousands of years Christians have believed in Jesus Christ. Christianity must be true, to have persisted so long even in the face of persecution."

Sounds familiar? Straight out of the book. [1]

What's more, just because its natural or plants doesn't mean it is safe. Example: botulinum toxin the most toxic toxin known to mankind which you might know better under the name botox, entirely natural produced by bacteria.

What matters is that it is standardised, of known origin (traceable/provable), well studied in clinical trials, and the mechanisms well understood.

SSRIs fit all those characteristics, only the latter one not.

We certainly did not have thousands of years of standardised, safe human use. Heck, we didn't even have thousands of years of safe human use to begin with.

We didn't have known origin (a good movie about this is Into The Wild [2], btw). Especially not with amateurs. Doctors were more proficient, but not for thousands of years with every substance.

And studies, back then not. You had doctors and witches.

We've come a very long way.

> Mushrooms appear to be one of the safest mind altering substances known to man, and if used responsibly, can be healing.

> Of course, they do show you what's inside, and for many people, they is going to terrify them. That is sort of the point though, to stare down the parts you've long ignored.

I have used psilocybin, A. muscaria, Ayahuasca, MDMA (or God knows WTF it was) among a myriad of other drugs (the first 3 bought online when it was legal in my country). Terrifying it was -for the most part- not. I had fun and insightful experiences, but now that I am older I realise I was reckless [because I am sensitive to drugs and have autism]. I know you too will, at some point in your life realise how reckless you were when you used recreational drugs. And then you will perhaps realise how reckless it was to recommend that to random strangers. And perhaps you will feel utter regret. Au revoir, all the best to you.

[1] https://infidels.org/library/modern/mathew/logic.html#antiqu...

[2] https://www.imdb.com/title/tt0758758/
NN has concept of 2D image built in - conv layer for example: http://cs231n.github.io/convolutional-networks/
>What if tPA worked like the starter motor that turns on a car, and urokinase was the gasoline that ran it?

No comment on the underlying science, but I will express my continued frustration with popsci writers and their counterproductive analogies. It's especially unhelpful when it's wrong on the dumbed-down end. A starter motor does not run on gasoline. It's an electric motor that runs off the battery.
Maybe because involvement of Germany is irrelevant to the article's main point. And could generate boring conversation.
I'm still using one now as my main phone. The only thing I don't like about it is how you have to hold the on-screen camera button down to auto-focus before taking a picture (making it difficult to do with one hand). Other than that, I've had no issues with it.
It's not just a political statement. He/she provides a practical effect of cryptocurrency on their life:

>>I´d rather buy bitcoins from localbitcoins in less than 5 minutes than risk my safety buying USD from some really speculating, shady people. I invest most of my crypto savings long term in alt coins

For someone whose private wealth is always at risk of seizure, and is in a impoverished country where the majority are at the brink of extreme deprivation, it seems pretty reasonable that cryptocurrency would help.
> I could be wrong, but i suspect this company is some sort of extended flight of fancy for someone who is either good at CGI, or wealthy enough to afford a lot of it.

Seems like it. Their YouTube is a treasure trove of unfundable and impractical bad ideas. It's an interesting blend of ekistics, vacuum tubes and conveyor belts and more conveyor belts. Their restaurant concept is hilarious.

The truck is basically a 3-axis CNC mill. It's a bad idea because:

- road surfaces are complex and are not always flat

- stuff underneath road surfaces are complex

- a truck carrying all those slabs of granite all the time is going to cause more potholes

- hardness differential between road asphalt and granite plugs is going to cause more damage down the road

All their other ideas are similarly easily refutable.
Don't see a way to do that in the web UI. There's a "To" box in the first page for filter setup, but no obvious way to negate so as to specify "NOT To".
I lean forward (elbows resting on thighs). I've always done it. I never even thought it was a thing not to lean forward until I saw/heard advertisements for the Squatty Potty.

That, spreading cheeks when sitting down, and a decent diet means almost zero clean up.
Owning part of a fund is equivalent to owning part of their holdings, which includes owning the means of production owned by those companies in which they hold shares. I don't agree that it's semantics to point out that the divide between "owners" and "workers" is not at all clean in the US.
OK, thanks!

Sounds like a massive business opportunity for banking. Your village may not have an ATM but I bet it has cellphone signal. Wasn't every Kenyan SMS-ing money around a decade ago?
It was OK. Nothing new that wasn't covered in 'Humans need not apply' short documentary.

I wish they'd explored some of the topics a bit more in depth.
You understand that T1 and T2 are very different diseases? That a Keri diet works extremely well for T2, but varies in efficacy for T1, ESPECIALLY in children?
Presumably, by using a physical weapon to coerce you to give them your hardware.

https://xkcd.com/538/
> The whole point of taking SSRI's is to affect the mind, so they are literally psychoactive.

Yes, they are; I meant psychedelic/hallucinogenic.

> They are better studied, but the risks you mentioned are associated with SSRI's as well as LSD.

Yes, but the possible side effects are well documented and users are informed and screened beforehand and there is professional guidance (by licensed professionals who studied for it) in contrast to recreational drugs use.

You know better what you dabble into when you follow the regular scientific path than the alternative path which is full with shenanigans, amateurs, wannabe experts, hippies, and downright dangerous, sick human beings.

> LSD not being studied as much doesn't mean it's more dangerous than any of the SSRIs.

Ultimately, this is irrelevant. You look at the current scientific evidence when you decide which treatment you want to follow. Recreational usage of LSD to self-medicate is very low on that list: actually, it shouldn't even be on that list until its scientifically tested in clinical trials. The lack of that doesn't mean we should just suggest it to random strangers; we ought not to!

> Do you have evidence/study that shows LSD is more dangerous than SSRIs?

No, stop turning it around. The burden of proof lies at you. You claim LSD is as useful or more useful than SSRIs.
Yes, that's highly Orwellian and terrorism is an absurd justification. Anybody capable of pulling off a terrorist plot requiring a phone is likely to be able to find a way to get one without such a regulation making a problem for them.

What it does enable is surveilling a person's location and some of their communication without having to do something requiring resources and the possibility of alerting the person that they're a target.

For the record, it's not unusual to be able to buy and use a prepaid SIM card anonymously in the US. There have been a couple proposals to ban it, but they came nowhere near passing.
Is a common question, don't worry.

Remote working + business within the country. I can't really leave as opportunities for me are here. Other people do have to flee as they dont have USD income or good living conditions so emigrating is their only way, most of my family is outside too so I travel back and forth alot.
> pronouncing the Danish/Norwegian word "dag" (day) in Norwegian. ... In Danish it's pronounced like the English "day". WTF?

This is consistent with the pronunciation of "jeg" (=I, as in myself) in Norwegian, where the 'g' is a soft sound.
I suggest not hanging anybody. You have reading comprehension issues.
What justification is given for this?
Link to the (development version) docs https://www.postgresql.org/docs/devel/static/jit.html
Why do men sexually assault women?
> I wonder if AWS will incorporate these improvements into Redshift, which is Postgres forked for OLAP use cases where this is far more prevalent. In the past, they haven't done a great job at this (ran into a float bug fixed upstream 5+ years ago), but this may be a big enough value proposition to justify the effort.

Redshift is forked from ParAccel, which was originally forked from Postgres several years ago. ParAccel has had code generation (via transpilation to C) since long before Amazon even purchased its source code. In other words, Redshift has had this feature since its inception, albeit via C-transpilation (compiled with GCC) not LLVM codegen.

In addition, Redshift's primary index is a column store which is particularly well-suited to code generation (you can inline and even vectorize expressions across rows, without hopping pointers in between rows). Postgres does not yet include a column store, but this piece of infrastructure is a big step in the right direction!
Amazon as a whole is willing to try things that might fail[1]. Yes I work at Amazon, yes it sounds a bit cultish, so be it. When people aren't afraid of losing their jobs because of one product misstep it's a lot easier to deliver stuff quickly. Instead of getting bogged down in endless meetings debating hypotheticals you can ship an MVP and get real customer feedback about whether the decision was correct. Every company pays lip service to taking smart risks but few actually follow through on it.

[1] https://www.forbes.com/sites/ryanmac/2016/04/05/jeff-bezos-c...
Ooh nitpicking! Okay, I’ll bite, so let’s just go through the top 10 from 1998 and 2017 to see if there is any dynamism or if it’s a static body like you’re suggesting.

1998, 2017:
1) GM, Walmart
2) Ford, Berkshire Hathaway
3) Exxon, Apple
4) Walmart, Exxon
5) GE, McKesson
6) IBM, United health
7) Chrysler, CVS
8) Mobil, GM
9) Altria, ATT
10) ATT, Ford

Wow, outstanding ! As you can see there are a number of companies that are new, dropped lower ranking, moved up in ranking, and completely disappeared.

We could keep going even further back a decade and the changes will be more visible. There’s a few companies who are entirely gone from the top 10, and I can guarantee that none of them wanted that outcome.

So to you, I say, got any more nitpickings?
Same here. I have a six character gmail address which includes a common name, and I get an average of between one and two misdirected emails a day, sometimes more. Stuff from all over the world, signup emails, invoices, love letters, confidential documents, etc. Mostly the non-dot version, but sometimes a version with one dot. It's infuriating, but I couldn't possibly change my email address at this point; it's tied to hundreds of accounts :(
How accurate is the comparison with plant fasciation, for anyone who knows more? My experience with owning/growing fasciated succulents (usually referred to as "crested" by growers and collectors) has been that they're more challenging to grow in terms of risks of things like overwatering, but as far as I know that behavior doesn't necessarily impact their overall lifespan. Sometimes a crested specimen can also revert back to normal growth. Maybe that's tangential to the article itself, but it's something I'd be curious to find more information about.
Many of these scams are based on people clicking links provided in emails. Just don't ever click on those links. Go to your favorite password manager and log in yourself.
You skipped the line to create the bare table first in SQLite: https://www.sqlite.org/cvstrac/wiki?p=ImportingFiles
They only have on app because Smalltalk if agile enough they build everything they need into it as the need arises - and this has been maintained over many years.
Demonentisation has nothing to do with cashless. it was an afterthought. So no connection to Aadhar.

So you are no different in making propaganda.

Aadhar is here to stay no matter how much fearmongerers whine. It's benefits outweighs risk. A good data protection law is what lacking.
This seems extraordinarily unlikely, google pays a lot of attention to user agents.
I'm not a fan of Obama but one good thing he was doing towards the end was cracking down on fraudulent "higher education" programs milking students and the taxpayer. He was deliberately choking off the loan subsidy fraud game. Unfortunately, Trump immediately resumed the Bush policy of pumping up the student debt for worthless degrees bubble.
Homeless in Seattle
I built an app that was 90% CRUD a year ago and I choose Loopback, but FeathersJS was on my radar. Loopback did the trick, but I just hated defining models in JSON instead of JavaScript objects. Good to hear FeathersJS on HN. I’ll check out the project again.
Oh I don't disagree. I think the entire culture and system isn't set up for proper integration of psychosis. So given the current landscape, it makes sense that outcomes are so poor. It takes resources of time and emotional capacity to make it through.

Dr. Paris Williams has an incredible book called Rethinking Madness that was instrumental in helping me adopt a framework to complete a psychosis.
Anthropodermic bibliopegy
Recently switched from a Lumia 925 to a 950, which I'm using to type this. This is my third Windows Phone and my first experience of WP10. There's a lot to like about it, but I do miss WP8.1. the keyboard is not as good on WP10 - it feels the same and looks the same but it doesn't predict the right words in swipe mode half as often as WP8 used to.

I'm torn between the eternal storage and incredible camera on the 950 and the better keyboard on the 925.

I wish there was something in between, like that Lumia 940 that never saw release
That's the whole point of the analogy. From the next paragraph:

> When a clot forms, tPA in the bloodstream is quickly recruited to the site to begin dissolving it. But too much of a clot-buster could lead to bleeds, so once the process is sparked, the body rapidly clears out tPA. Urokinase comes along, carried on the surface of platelets and certain white blood cells, to finish the job.

tPA kicks off the process, and once it's started, urokinase does the rest. I don't know the biochemistry in enough detail to say whether this is a really good metaphor (can urokinase only be activated if tPA has acted? is urokinase consumed by this process?), but the author is not suggesting that a starter motor runs off gasoline.
Theories he has stated or expressed approval of:

• Obama was not born in the United States.

• Climate change is a hoax.

• Ted Cruz's father may have been involved in the Kennedy assassination.

Want more? Just Google for Trump and conspiracy theories, and you'll find plenty of articles covering a bunch of them. Example [1].

> Unless it's well-known fact or something agreed on by everyone, making such a bold statement would require you to prove your case. Not the other way around.

He tweets about this stuff frequently. Those tweets are well covered in the press. So yes, it is well known.

[1] http://www.businessinsider.com/donald-trump-conspiracy-theor...
And sometimes it is difficult to aquire and hold USD.
The Curse of the Bradford Pear
I should have been more clear. I'm talking about after filing of returns. You have to verify it. It's either sending the signed acknowledgement to CPC or everify it digitally. Have you sent the signed acknowledgement to CPC? It's mandatory to send acknowledgement to CPC if you haven't digitally signed it using DSC or Aadhaar. Please check with your CA as the rules are same for personal and corporate income tax.

EDIT: Procedure to verify your submitted tax return: https://www.hrblock.in/guides/itrv-download-guide/
Ask HN: Command Line Analytics Tool Buzzfeed?
Trying to find a post from the past 6 months or so where the author may have submitted the command line tool to Show HN that helped summarize and run quick look analytics on CSV data sets. I believe the author was an employee at some point at Buzzfeed in their data group.

I know this is fairly generic but I'm hoping someone remembers this post or if the original author can link to it. I wanted to experiment with the tool. Thanks.
Yes. I have 20 years of experience, so I know their pain points.
The comment above is the one of them. Short after revolution in Russia, top communist had meeting about how many people they need to kill (so new, better Homo Soviet, will emerge and build communism). They decided that top 10% of population must be killed.

These meetings notes were secret, but after drop of Iron Curtain, American scientists were able to read them for few years, so they scanned them on microfilm, then digitized back to text and released to public, so I read them. I forgot name of University where they are, but I will try to find them again, if somebody is interested.
>Because depression isn't a lifelong thing, it should be at worst episodic.

Says who? The DSM-5 specifically lists Persistent Depressive Disorder, formerly known as dysthymia, which is defined by chronic depressive symptoms for a period of two years or more. Many people suffer from frequent episodes of major depression; there's fairly good evidence that antidepressants can reduce the risk and severity of relapses.

Patients shouldn't be taking antidepressants in the long term by default, but it's a very good option for a lot of people. If you've had two or three previous episodes of major depression that have been successfully treated by antidepressants and you find the side-effects tolerable, taking them indefinitely might be a perfectly sensible decision.
Kinda like Airbase. Trying out the app. I guess you’re hiring SF only. Not Seattle remote.
Exactly that.

Most of the "bargain rates" usd comes from small transactions of people sending USD to their family in Venezuela and are not up to date with pricing or inflation.

You can see people still selling USD at 210,000 VEF while bitcoin usd is almost hitting 400,000 today.

Others just buy alot of merchandise of any kind in VEF (stock it few months) and sell it at big prices later.
The favored course of action is interventional radiology and those guys like to get done and move onto the next patient to rake in the dough.
In fairness, that was the lens the narrative played up. The other side is, “doctor pursues combination of two apparently shitty drugs for decades without anything but armchair hypothesis for support despite massively accumulating evidence that they suck independently, fails to garner attention/interest.”

He might be right, but I’d hesitate to lean too hard on the lone genius angle.
The surface hub actually ended up being close to a billion dollar business for Microsoft, which I would say is pretty good for something that costs 5k+ and is out of reach for most consumers.
We're talking about a phone OS here.

If they just wanted to haul out a 2009 phone out and use it, they could do that just fine, with no open sourcing. You can still buy them off eBay. Since they haven't done that, you might consider that they want something else.

I also disagree that using one of those today would make somebody not miss it. What they could reasonably miss is what it could have been. That's certainly what I'd love to see: a WebOS grown up, with a decade's investment along the lines of the original.
Corporations are more multicellular organisms than cancer. They are capable of achieving far more than a single cell or person, for better or for worse.
I still use it, and will continue to until I can't anymore. I'm on my third Windows Phone, which I bought just a few weeks ago. I've tried to switch to android, but after a few weeks I missed pinning tiles, and the simpler gallery and superior keyboard
A large portion of my gmails are incorrectly sent. I have a standard response ready.
I can appreciate that, but to me it feels like a deux ex machina given how the events unfolded up until the end. I think it demonstrates a cultural difference between Americans and British- by taking the route of personal growth, the book goes against the dour, nihilistic ending British would expect. I don't remember any buildup to Alex's epiphany, so I found it unsatisfying.
Would Legalized Sports Betting Help States Get Out of the Hole?
>why would anyone do that with bitcoin when they can buy USD

How is a Venezuelan suppose to buy things online with paper USD? If you have to order medicine to stay alive because there's a scarcity in Venezuela, you cannot use paper USD for that.
Celiac disease is far more severe than what's now called "gluten intolerance". But maybe they're related.

I get that "Celiac disease results from genetic abnormal immune response to gluten."[0] I'm not sure what that means, in detail. Perhaps there's a particular allele of one of the immunoglobulin genes. But whatever it is, perhaps other alleles cause "gluten intolerance" of varying severity.

0) https://www.ncbi.nlm.nih.gov/pubmed/16095159
I don’t understand what you mean by a “CF that creates exactly one conversion”.

Anyways, your response isn’t relevant in that I’m not suggesting an email address should (not) be verified. Rather, we’re discussing whether verifying identity needs to come before or after (or alongside) the transactional email - e.g. a receipt of purchase.

At the same time, validation and verification are not the same thing - and sometimes it’s not necessary to perform address/identity verification.
Again voter ID or ration card is not unique.
Have a look at what the ancestors of the current Pacific Islanders were doing for a few thousand years. They lived in an environment where growing food is easy and starvation almost unknown, contagious disease minimal, yet the population static. Which of the four horsemen was responsible?
That works for the usual, accidental missing-dot case. Won't work for phishing that injects a '.' in some other position.
> to the bone

You would work to the bone too if you were getting rich off of AMZN stock options.
Show HN: Paint Brush,Snapchat AR lens where you can doodle/sketch in your world
https://www.vox.com/new-money/2016/12/28/13889840/amazon-inn...

"… experiments start small and grow over time … Amazon creates a small team to experiment with the idea and find out if it’s viable. Bezos famously instituted the “two-pizza team” rule, which says that teams should be small enough to be fed with two pizzas … new teams get limited funding and clear milestones; if a team succeeds in smaller challenges, it’s given more resources and a larger challenge to tackle.

… Amazon doesn’t spend too much time on internal testing. “They prioritize launching early over everything else,” … Bezos has been fanatical about letting teams operate independently of one another … discouraged the kind of standardization you see at companies like Google and Apple, encouraging teams to operate independently using whatever technology makes the most sense … to make Amazon a modular, flexible organization with a minimum of company-wide policies.

That has made Amazon’s internal culture somewhat chaotic and balkanized. An engineer on one Amazon project can’t easily jump to another the way they can at Google or Apple. Friction between teams with different cultures may explain why some people find Amazon a stressful place to work. But this chaotic culture is also hospitable to innovation. A new team can use the tools and processes that make the most sense instead of feeling pressure to conform to company-wide standards."
“German language needed”. That seems to severely restrict your application pool right?