skysight-inc/HackerNews huggingface dataset:
If you are old enough to remember the hype about resveratrol and sirtuins, that eventually resolved to nothing at all of any great use for human medicine, this is basically the same people singing the same song about roughly the same area of biochemistry. On the face of past events, they can't really be trusted to tell you how great it is and how promising it is, so just read the facts and compare with other studies.

About the most one can say about this is that manipulation of NAD+ levels is a better exercise mimetic than manipulation of sirtuins proved to be. What it helps to do is explain some of the underpinnings of studies that show a great deal of muscle loss is secondary aging - i.e. disuse. It also suggests that loss of capillaries is a more important mechanism in sarcopenia than other groups believe to be the case, though I think it very possible that this is secondary to stem cell activity loss. The evidence for stem cell decline to be the primary cause of sarcopenia is very good. [1] There is a faction that thinks capillary loss is important in all tissues. [2]

Go look at the studies showing resistance training to be pretty effective in seniors before getting excited about NAD+ boosters. The resistance training is probably cheaper and better. One still has studies such as the one showing that dietary nicotinamide doesn't do a great deal in mice [3] - like sirtuin manipulations, it helps fat mice a little, but is distinctly unimpressive otherwise.

Remember that calorie restriction extends life by 40% in mice, but probably five years or less in humans - the effects of all these stress response related mechanisms of metabolic manipulation work through a few overlapping core processes, and scale down with species longevity. That's why I see them as a dead end in comparison to other strategies.

[1]: https://www.urmc.rochester.edu/news/story/4788/stem-cells-ma...

[2]: https://doi.org/10.1159/000477402

[3]: https://doi.org/10.1016/j.cmet.2018.02.001
Isn't that why the individual mandate and the minimum coverage standard existed?
So old...
It isn't what I think about prices, it is the facts, ACA exchanges up 34% YoY. https://www.cnbc.com/2017/10/25/most-popular-obamacare-plans...
That’s still roughly the case, I work for a medical billing company owned by a physician group, we have a pretty large group and are essentially self-insured.

I pay ~$220-ish a month for my family of three, the company pays $800+/mo. Boy am I glad to work for a company that pays such a large chunk of my benefits, many other places cover maybe 50% of your dependent costs.
one of the problems with staying off blacklists, is that unless your smtpd is hosted at a very attentive ISP (not a bulk VM/VPS host), blacklists can encompass the entire /24 of IPs that your single server resides in. You have no control over the abuse of other VM/VPS tenants with adjacent IPs in the same block and may never successfully get it taken off some RBLs.
While true, I think it is important to emphasize the difference between 4 platforms and 4 carriers. With both postal mail and email, its not just that there are alternative systems, but rather that you as the sender can choose any of the offerings to reach anyone, even if they use a different carrier for their own needs, so there is a lot more competitive pressure on those 4 carriers than with 4 platforms where network effects keep people locked in.
A little data that agrees with your impression:

https://www.forbes.com/sites/theapothecary/2016/07/28/overwh...
This is great! But a shame no 32-bit ARM, for (slightly) older/budget android devices.

Although android is a kinda java, many things aren't available, such as invokedynamic (only in Android 8+), and javadoc (uses javac).

This is not to mention the functional and other stuff in later javas.
I agree that I do not exactly like forcing business models to companies. But I think especially facebook and google are currently so difficult to avoid that their users should be given a fair choice on how to pay for their services, with money or with data.
I don't see how Paxos or RAFT could be considered proof-of-stake? Nothing is staked in Paxos or RAFT, and there is no disincentive for bad actors.
You're going from a simple CMS to video hosting is like saying why ride a bicycle when you can build a lamborghini from scratch. Sure some people have the bank roll to try and launch a youtube, very few, but everyone can afford to spin up a wordpress or some other sort of CMS on a one click host.
I've been saying for years that software engineering needs to be elevated to the same standards held by other engineering fields; like civil, mechanical, biomedical, and so on:

If an engineer or a firm is negligent and people die and/or millions of dollars are lost, they are kicked out of the industry/lose their right to operate as a business.

For example: To work on cryptography and security, you need a degree and to have passed certification, perhaps at regular multi-year intervals. Then if you build a login page and store the unsalted passwords in plain text and someone pwns your site, you lose your license, could be fined, sued, or possibly go to jail if your negligence is criminal.

Then, if you are a company and you need a login system, you either (a) hire certified software engineers to write one, (b) subcontract a certified firm, or (c) license a certified off-the-shelf solution. If pwnage happens, the company is liable if they failed to do one those things. Therefore it becomes in the interest of companies to do security correctly, and of engineers to only attempt it if they are competent and qualified.

It's really simple: In other fields of engineering, there are consequences if you fuck up. If you design a bridge that falls down and kills people, you lose your career, are sued, and/or go to jail. Not so in CS. That needs to change.
Did you get any sense of how they ran their businesses?

My doctor was part of a medium sized practice that was swallowed up by a big regional system. Since that acquisition, they make the .gov that I work for look efficient and streamlined. They literally added 5-6 non-billable staff to an office that was staffed by 2. Per my doctor, that’s typical in most offices!
if you are interested in this or other projects, GSoC is now and the deadline for student applications is 27 March (tomorrow).
And by what mechanism does insurance linearize individual risk? The fact that if I get cancer, it's less likely to bankrupt me. But if it's not bankrupting me, someone else is paying for it. Who's paying for it? Someone who didn't get caner. So how is this not "less risky people subsidizing more risky people"?
The correct title is "How can Facebook change when it exists to exploit personal data?" (Looks like a 'N' got typo'd in there instead of a 'H')
Financial Aid Funding Cryptocurrency Investments
So current free to user companies just get to hold their market forever? Are you that happy with them?
That's only true if you ignore the long-term externalities of centralization.
Whose 'they'? And after all those sketchy apps asking for your friends list all these years? Yeah. Yeah I did.
I definitely agree that PoW is very hard to understand because it is not a computer thing, it's about the relationship between large number theory, thermodynamics and statistics/probabilities.

I describe it to myself as a clock, I've written my thoughts down here, you might find it interesting: https://grisha.org/blog/2018/01/23/explaining-proof-of-work/
Simple, just void the warranty on your brand new $5000 computer. Something you can't easily get parts for, and Apple is the only person who can repair it. It's not worth it.
Worked well for me. I imagine when most people import their trades they will be very surprised by what they owe. I had no idea (but it makes sense) that when I gave some bitcoin gifts it followed the FIFO rules despite the fact that I had just purchased some to gift.
How do you make sure you're actually getting catastrophic coverage for $3k? The information asymmetry between insurance providers and customers heavily incentivizes the creation of "value" plans that achieve their "value" by appearing to cover more than they actually do. Since only a tiny fraction of customers ever make catastrophic claims, most people will be unaware that they are buying garbage even if a policy were to never pay out (100% lemon-drop rate). Is your due diligence sensitive enough to pick up even a severe 50% lemon-drop rate (affecting, say, 0.5% of customers)?
The injustice of the system is that self-employed have to pay with after-tax dollars while your employer can deduct the cost of providing those benefits.
Is Sunnyvale a 'ritzy' city? I've visited the Valley more times than I can count and that's not my impression of Sunnyvale. Am I mistaken?
Apple's epsilon reset problem is real, but it's worth pointing out that they use additional heuristics based on hashing that plausibly add another layer of privacy [1]. Plausibly, not provably, but it's a bit more than just resetting epsilon. I believe Google and Microsoft use similar tweaked forms of differential privacy. In particular, note that all of these companies -- again, going off public papers -- use the "local" variant of differential privacy, which requires less trust on the user's part.

The question of "lifetime" differential privacy, for a single user across different computations and datasets, is still fairly open as far as I know.

[1] https://machinelearning.apple.com/docs/learning-with-privacy...
You're still the one paying the $800, the only benefit is you get to do it with pre-tax money. It's not like that money comes out of the aether, it's part of your compensation.
I was referring to the concept of delegating decisions to a (somehow selected) single node, though in those particular cases there is no "stake".
It is impossible get their real profit so they are taxed 2% on their revenue. Oh and I forgot, when the authority requested them to hold a meeting on how should the taxation be, they didn't even bother to reply! That's like asking for trouble.
Even things like Goyo? Then it's pretty damn great. Even though I hate Electron apps. Thanks, I need to try it.
Managers are basically information routers:

1. They make sure info goes from one place to another with minimum delay. If the team needs tool X, they get them tool X as fast as possible.

2. They work on a lower level, closer to the team, to discover any issues the team has before it's too late.

3. They understand their team better than any seniors, and can give a good estimate of how much resources are needed and how much the team can output.

Managers also work out of the team. They work on it like it's a machine. If one part breaks, they don't simply fix the part, but tweak the process so it doesn't happen again.
I'm not sure how you interpreted that, especially since I'm arguing for regulation.

It's not that others can't comment but that their ideas (in this linked article) are poor and betray the lack of experience of the advertising industry that underlies it all. Facebook is not a new threat and focusing on it as a special instance completely hides the other major actors in the world that are doing and allowing the same thing.
Andi f anyone can find it the documentary "The box that changed Britain" http://www.bbc.co.uk/programmes/b00scpzn is really good, especially on the social aspects (e.g. dock workers and indistrial heartland collapse).

EDIT found a version online: http://www.dailymotion.com/video/x5f7n8v
I plan on picking up solid health insurance coverage as well, of course. This is just so that my insurance company and health care provider can't screw me over through balance billing.
Most dictionaries have a broader definition. Here's the ACLU:

> Censorship, the suppression of words, images, or ideas that are "offensive," happens whenever some people succeed in imposing their personal political or moral values on others. Censorship can be carried out by the government as well as private pressure groups.

https://www.aclu.org/other/what-censorship
How well does that system work for a generation that produces fewer adults than are present in the generation?

Instead of paying for other peoples health insurance and then other people pay for mine, why can't I just save the money that I would be paying in premiums above and beyond what the rational amount would be and then pay for my own health care when I get older(or, pay for the higher premiums when I get older)?
As I understand it (I hope I understand this, because I rely on it), LLC principals are allowed to deduct the cost of health insurance.
> Medicare is why hospitals exist, period. Private insurers make it as difficult as possible to stay in a hospital, because they are more expensive and usually result in worse outcomes

this is not true. check out the annual financial reports for the UC hospital system as an example [0]. the majority of revenue comes from commercial payers. looking at data from HCA (largest public hospital company in US) tells similar story [1]. this is despite the fact that medicare patients are more costly overall

the bigger issue, however, are the margins. in 2010, UCSF, UC Davis and UCI had 3.5% profit margin for medicare, -27% margin for medicaid, and 21.8% margin for commercial. for UCLA they had -30% profit for medicare, -36% for medicaid, and 34% margin for commercial. private insurance literally subsidizes public insurance here. without private insurance, those hospitals die [2]

looking at other hospitals id imagine it is similar, though dont have data offhand

as to the reimbursement rates being squeezed bc of glut of beds, i dont think that is true and have seen data in the past to refute it, though i dont have the sources offhand.

[0] http://regents.universityofcalifornia.edu/regmeet/nov13/a4at...

[1] https://www.sec.gov/Archives/edgar/data/860730/0001193125180...

[2] https://www.oshpd.ca.gov/HID/
No, that is not how insurance works. Insurance works well when you group people with similar risk profiles together, not by grouping people with dissimilar risk profiles together.

Imagine a world where a 20 year old would be able to buy a 10-year term life insurance policy for the same amount that a 90 year old can. That is essentially what the ACA attempted to provide.
I feel like someone should also give Zuckerberg the memo that it's only a matter of time before an insider also goes rogue and abuses data access (edit: or otherwise; see below). Facebook fundamentally seems to trust itself way too much, and it worries me that it thinks the only threats are external entities... to me, this is another silently ticking time bomb.

EDIT: And don't forget that going rogue is just one scenario. Another is just a bigger attack surface: the more insiders have broad system access, the more credentials there are that can be phished by/leaked to/stolen by outsiders. Really, it would be completely missing the point of security to have arguments about how exactly insiders' credentials might get compromised.
That article, aided and abetted by the terrible writing in the Brookings article it's criticizing, is comparing apples (the rate of increase) and oranges (the actual increase). There's no controversy that health insurance rates are increasing; they've been increasing dramatically since the turn of the century.
Apple became the most valuable company in the world in 2012 (https://www.forbes.com/sites/davidthier/2012/08/20/apple-bec...) and had been a leader for the better part of ten years before that.

A recent change in procurement doesn't change the fact that they grew their business on the backs of teenagers who were sent into unreinforced holes in the ground to dig while kindergarten age children crushed the ore without the benefit of any protective gear.

I'm an iPhone user and I understand the world is a messy place. My point is it's rich of Cook, whose sub-contractor had to install nets outside of windows to prevent suicides, to lecture Zuckerberg about morals.

At the end of the day, Facebook has built an incredibly powerful adtech platform. An unpopular person used it to get elected. That's bad. Tim Cook's career has been spent building workplaces that either crushes spirits, leading to suicide, or literally crushes bodies in mine collapses.
Seems like good advice, but harmful if followed through to it's ends. How do you approach it when you want to learn many things, but videogames are what give you the most pleasure? or drugs? social media?

I agree that life is too short to not being doing the things you love, but how do you reconcile that when the things you love are not practical and can never lead to a bigger paycheck? are you just expected to do work you don't love to make rent and have some pocket change for food? long term be damned?

I love music, I've stuck with it for most of my life, I also recently found a deep interest in programming. but like music, programming takes work to get better at. But you know what gives me a rush beyond both of these? videogames. Should I set aside my lofty interests (which I won't improve at without frequent experience) and just do what gives me short term pleasure?

Maybe in a society where I didn't have to work to live. If music could pay the bills (lol) then I could envision not even diving that deeply into programming. But as far as life goes, I'm hellbent on finding a place in society that doing something I love, that will not leave me impoverished.
It should be noted that the military and athletics are both areas that tend to select for people with good sleep to start with (since poor sleep has negative impact on the things they look for) and then often overwork people. So the high success rate is not surprising in those conditions. Sleep is not just the result of both physical and mental relaxation, although most people are likely to be able to sleep in that situation. Every self help book on sleep has varitions of this technique and many people find it helpful, but not everyone is able to sleep quickly even with relaxation.
Empirically, I have brought modded Macs to Apple Stores and they have fixed unrelated issues without saying a word. IANAL but there are consumer protection rights keeping your warranty rights depending on where you live if you don't actually cause a damage while you're adding a HDD (FFS, it does not even need soldering or anything; more like playing with Legos: https://www.ifixit.com/Guide/iMac+Intel+27-Inch+Retina+5K+Di...).

BTW, iMac 5Ks have been out for a few years now. Many of them are probably out of limited warranty anyway. $5k is quite a bit of stretch on the price approximation for an average iMac out there too.

In my experience, going to an Apple Store as opposed to an authorized repair shop is the way to go (I have had bad experience with the latter). Charming the "genius" on the other side of the bar is not a bad idea either. :)
Man up and resign...
It’s the asthma for which you are near-guaranteed to need $5,000 worth of treatment for that’s the issue, not the small chance you get cancer.

You’re not looking to insure against the chance you get asthma: You have asthma, and you’re looking for someone healthy to help pay for it. If too few healthy people sign up for Obamacare relative to the sick (and remember, all else equal, they have to be charged the same regardless of their health) those healthy folks will get an increasingly bad deal as their premiums are covering the costs of more and more sick enrollees and more and more healthy folk drop out of the exchanges. That’s the “death spiral”.
This story is couched in terms of how bad things were before Obamacare, but I’d like to point out that things aren’t great now either. To prevent Obamacare from bankrupting them, insurance companies are resorting to legally dubious mass-denials, one of which affected me personally.

A few months ago, I woke up the next morning after eating some fast food and began vomiting. I couldn’t stop throwing up, and I couldn’t eat anything, for 2 straight days. I had a 101 degree fever at the worst point. At the beginning of day 3, when I vomited so hard that I passed out for a few seconds and fell on the floor, I went to the ER. They gave me IV fluids and anti-nausea medication, which worked.

About 2 months later, I received a letter from my insurance company (Anthem). They had determined that my situation didn’t qualify as an “emergency,” and therefore they were denying the entire bill for this ER visit. I have appealed, and so far it has not been overturned. I am now on the hook for thousands of dollars, even though I had already covered my entire deductible for the year.

I thought that this had to simply be a mistake, but then I learned this is actually a new policy that insurance companies are implementing in the era of Obamacare [1]. Patients are expected to self-diagnose whether or not their situation meets their insurance company's definition of an “emergency,” and are rolling the dice as to whether or not an ER visit will be covered.

[1] https://www.vox.com/policy-and-politics/2018/1/29/16906558/a...
Neither me the OP said that but to suggest that a brokerage or crypto exchange is being unprofessional by not being able to provide a 1099 in all cases is to ignore reality.
I'm not familiar with the service, why isn't a it good for individual/small/medium teams?
Who says it hasn't happened already? How would we ever know? For that matter, how would Zuck?
You'd think so, but most companies have pretty strict internal controls for this sort of thing. Access is also carefully logged so a leaker is pretty much guaranteed to get caught at which point they'd immediately lose their job and likely face criminal prosecution.

With so much to lose and so little to gain internal leaks of this sort are extremely rare.
What could they possibly do to fix things that wouldn't destroy their business model?
These performances by CEOs before their employees to “calm” them reminds me of Jonestown or some other cult.

Everyone kind of knows the leaders are corrupt liars and false prophets. It’s all a scam. But they’ve invested so much of their lives and identities into the ideology, there’s not really any turning back. It’s like some “When Prophesy Fails” inflection point for the whole industry.

https://en.wikipedia.org/wiki/When_Prophecy_Fails
I've only dipped into Go recently (and not for any production code) but your article very nicely summarises my impressions with it so far. I've found a kind of fluid pleasure in writing Go that wouldn't be apparent from a bullet list of its (lack of) features. It really allows my attention to fall mainly on the problem domain in a way few other languages afford.

I can't resist while here thanking you for i3. I've been a mac user recently, but will likely be back to linux in the next year or so. Using i3 again will be probably be the greatest pleasure involved in that return ;)
Grep'd the articles and the comments (thus far) and I'm amazed that nobody has mentioned matrix,

Check it out - matrix.org

PS: Even more importantly, the Host Identity Protocol. The US army has been using it for over 10 years. If that doesnt speak volumes ...
Yes. But the mandate was always pretty toothless and has now been completely defanged.

Regardless, the idea that under ACA “the healthy pay for the sick” as expressed by Ryan was certainly not an oblivious truism about the nature of insurance as it is being portrayed.
Last year I didn't care because I couldn't afford the ACA, and Christian Medishare met the Obamacare requirement to carry insurance or face a tax penalty. The "health care sharing ministry" operates differently than insurance, my concern isn't denial of coverage but that the entire enterprise will collapse.
https://en.wikipedia.org/wiki/Health_care_sharing_ministry
And I actually worked in insurance. The Fortune 500 company I worked for paid for me to go to school 8 hours a day for 3 months. I got a certificate from a technical college and additional training.

Obamacare is a terrible solution.

But don't let industry expertise stop you from your usual antics of feeling like no one is allowed to disagree with you and you need to win every argument, even if it means harassing anyone commenting, never mind that they weren't replying to you.