skysight-inc/HackerNews huggingface dataset:
I have had ketamine infusions (approximately 15) under medical supervision, where a general practice MD, in his office, but in consultation with my psychiatrist, administers a specific dosage (usually starting at 0.50mg/kg, going up to 0.80mg/kg) calibrated by your weight and previous responses using an infusion pump, set to deliver the dose under an exact 40 minutes. Each session in (my case) costs $600 cash, out of pocket, with no insurance reimbursement, other than (in some people's' experience) potentially a small portion refunded (the "office visit" portion).

The infusion is conducted in a quiet, darkened room, and I'm checked in on periodically over the 40 minutes. The session makes you feel somewhat "out of it", but not "trippy" or "dissociative" or "psychedelic" in any way. It seems to give you an ability to put things that are causing depression or anxiety "in their place" so they cause less ongoing turmoil. There is conflicting evidence as to whether any of the perceived effects of the infusion have any of the antidepressant benefits or whether the benefits are solely chemical (and not in any way a function of any of this "enlightenment" that may be provided by the infusion).

It's a somewhat enjoyable experience but not "fantastic" or one that makes you feel like you want another infusion right away. The poster who insufflated the ketamine likely had a much higher dose over a much shorter period of time than the dosage used for an infusion, and reputable doctors generally give the infusion over 40-60 minutes, not all at once, and not via insufflation. Some doctors will prescribe a ketamine nasal spray or lozenges for use between intravenous sessions, but they are few and the evidence isn't really there for any potential benefit to this practice.

I have noticed a positive effect on my mood and depressive symptoms generally recently, but I have also had a full course of TMS during the same period of time, so it's difficult to attribute the benefits to one modality over the other. TMS, unlike ECT, does not involve anesthesia or shock therapy, and unlike ketamine, TMS is usually covered by insurance. However, it generally requires 30-36 visits to see improvement, so the timing is distinctly different from ketamine when ketamine works. I would think I'm a medium responder to ketamine and a medium responder to TMS.
We've banned this account for violating the site guidelines. If you don't want to be banned, you're welcome to email hn@ycombinator.com and give us reason to believe that you'll follow the rules in the future.

https://news.ycombinator.com/newsguidelines.html
> Sleep deprivation really has opposite effects in healthy people and those with depression

I used to "play" with my sleeping pattern a lot. I would stay up extremely late sometimes because it's impossible to go to sleep before a bug has been fixed. But being a student I could just sleep in the next day. It had that classic effect which is observed in hackers of drifting "West" and becoming completely out of phase with the Sun's cycle.

I did suffer from depression. It's always difficult to say this, though. How do I know that I really had depression and I wasn't just unhappy? I don't know. But maybe it suffices to say that I had near constant suicidal thoughts at times.

I've since turned my life around and I am no longer depressed. I attribute it to having a much more regimented life which includes regular and sufficient sleep, regular, healthy meals and regular exercise.

So the above quotation suggests that I am "healthy". Presumably as opposed to those that are "unhealthy" and really have depression. But what is the difference really? I have to do this particular thing to avoid depression, and they have to do that particular thing to avoid it? Is it just that my "cure" happens to be the same as everyone else's cure? Or am I missing something here?
> Really? Are you that immature?

Would you please not post uncivil comments to HN, regardless of how some other person behaves? It's not ok to break the site guidelines.

https://news.ycombinator.com/newsguidelines.html
ICOClap – Top 5 Unique ICOs
Go ENI! It's amazing how an Italian Oil and Gas company is working hard to collaborate with research with the aim of revolutionizing energy extraction.
This is inspiring and giving hope on the future.
Ask HN: Is it time to patch against Spectre and Meltdown yet?
I have several development systems ranging from an ancient Win 7 desktop through to a Macbook a couple of years old.

I've avoided patching until now, because I didn't want to run hastily written OS patches on systems I rely on; and because there didn't seem to be any wild exploits out there yet.

On the balance should I patch now or wait longer? What have you done?
The optimizer should remove that at compile time if it's not used.
Please don't make HN worse with ugly personal attacks.
Yeah, that's the real question. Especially since, according to the article, Swarm was already planning to make their future satellites larger after the smaller design was rejected. Why jeopardize that by launching the previously rejected units?
Now that is interesting. I had thought YBCO was easy to fabricate given I saw some amateur do it on YouTube, but I do accept they had quality control issues — important on large scale production.
Dirty (especially Russian) foreign money coming in to London had long been acknowledged as the cause of the extraordinary property prices. The sad thing is that the demagogues have managed to blame it on EU migration of blue collar workers. This was a big driver for Brexit.
Fusion is still exciting, but with normal renewable (solar, wind) costs plummeting the way they are is there still such a compelling case for pouring money into fusion? This one aims to produce a working plant within 15 years. I'm not sure that any of the other efforts are closer to being viable (if they work at all). That's the kind of time frame in which we may master offshore wind and grid-attached storage like the Tesla batteries. Might not even need fusion at the point.

(Except maybe for spacecraft, in the much more distant future)
Somehow my quackery detectors go off on this one, but I'm not quite sure.

The article talks about "recent studies" without linking to them. The "references" section at the end links to a single peer-reviewed article (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447205/) in a journal with an impact factor of less then one (compare https://www.researchgate.net/journal/0379-5284_Saudi_medical... for example).

If it works, why not give some citations in more reputable journals, for example?

Most articles, when searching for depression + sleep deprivation, talk about the correlation between the two, which seems to be pretty well-established. There's little on the possible treatment of depression through sleep deprivation.

I found a meta-analysis on the subject: http://europepmc.org/abstract/med/28937707

"The overall response rate to sleep deprivation was 45% among studies that utilized a randomized control group and 50% among studies that did not. The response to sleep deprivation was not affected significantly by the type of sleep deprivation performed, the nature of the clinical sample, medication status, the definition of response used, or age and gender of the sample.These findings support a significant effect of sleep deprivation and suggest the need for future studies [...]"

I don't have the qualifications to assess this meta analysis; at least it's published in a more popular/reputable journal.
I came to VSCode from Visual Studio with R#, which undoubtedly affects the way I perceive VSCode, but for me it absolutely flies, even when editing 200MB text files (not that I do that often, just saying)!
I use this for Django/Python development and it suits my work style very well. It does the 20% of a full blown IDE's functions that provide 80% of the value.

Apparently it is based on the long line of editors starting with scite, notepad++ and a bunch more.
Scapegoating the poor?

Who would have thought.
I’ve got the same setup at pfortuny.net/reflexiones plus amazon workmail and it costs me around 6$/month. Very low traffic, though. Anyway, the cost is 5$ for the mail, so the blog is negligible.

Amazon’s pricing is easy for this simple setup.
This is my bill estimate for March - kinda high!

https://imgur.com/a/kDmdE
I can anecdotally confirm that for me, sleep deprivation appeared to significantly alleviate symptoms of severe anxiety. Around a year ago I was having what I think you'd call panic attacks every day and general anxiety all day. I had a breakdown of I think about six weeks, mostly focused on my insecurity about not having a better job, masters degree, etc. Etc. I was non functional.

I read about the sleep deprivation studies then. One day I had stayed up very late anyway, so I decided I would just wrap it around and stay up all night. I had no job to go to anyway.

That day I had no strong attacks and generally felt far more relaxed. It was a great respite.

However, it's very temporary. For me it felt like respite, not a cure. A break from attacks and nerves. It came back over the next few days. I wish I'd kept a more detailed diary. Why I'm okay now I can't say for sure, however I sleep too little and quite badly now, being busy with work, clubbing, parties, and coding in my spare time, so there's possibly a correlation there - causation, who knows. I don't think eight hours of sleep is bad, I think it's beneficial, but I do think over sleeping is harmful to mental health and easy to do - my theory is that like high calorie foods, we didn't evolve with unlimited sleep available to us, so getting too much just wasn't a thing.

Of course, it's one data point and could be the placebo effect for coincidence, but, much like my experience using MDMA to improve a depressive attitude (careful: may make it worse for some people), the effect was real enough to me that I personally believe in it and think it can be valuable to at least a subset of people if used carefully.
For anyone really looking to recreate this and not already consuming THC: I already smoke every day! Obviously! Even a joint every 2 hours would put your lights out after a while. Go slow and use a vaporizer. I already have tolerance.
> IPv4

Don't rely on IPv6 for protection from scanning.

https://www.internetsociety.org/blog/2015/02/ipv6-security-m...
The article’s essence appears to me that that is unlikely to happen.
AI Has a Hallucination Problem That's Proving Tough to Fix
> It would be nice if the author (or someone) made available a mostly-automated process for filing similar claims by people who aren't lawyers. The same successful arguments should work for any of us.

That's not correct. Outcomes will vary per jurisdiction, judge, and the actual case circumstances.
Takeoff Aborted – Aero Glass Shutting Down
The original study: http://www.thoracic.org/about/newsroom/press-releases/resour...
Yeah it’s 2018 and still we send people in prison.
If you wanted to "lose" a satellite by launching it into a known orbit, you could design a satellite that is matte black, physically stealthy, with a very large supply of xenon propellant and ion thruster so that over a period of many months it could totally change its orbital plane into something new.

The USAF figured out how to detect such satellites back in the 1980s.[1] The Ground-based Electro-Optical Deep Space Surveillance (GEODSS) looks at the sky with three 40-inch telescopes per site. This automatic system has a big star catalog, and can detect when something blocks its view of a star. The telescopes are some distance apart, and so they can see time differences between something occulting a star and compute range. The multiple telescopes allow disambiguating problems such as clouds, aircraft, and birds.

If something looks interesting enough, one of the telescopes is switched to laser mode, and a laser flash is used to illuminate the target. Even black objects reflect some light.

GEODSS was the first fully computerized telescope system, and it generated far more usable data than film-based systems. One of the old GEODSS sites was used to look for near-earth asteroids for years, and found most of the known ones. Now, of course, everybody has multi-megapixel imagers on telescopes and enough computer power to analyze the results.

[1] https://en.wikipedia.org/wiki/United_States_Space_Surveillan...
Almost every application cares more about energy cost than energy density. I think only shipping (ocean, air, and space) care about energy density in any significant way, and the first two can fairly trivially use renewable-electrolysed hydrogen. (Space can also use it, but I wouldn’t say it is trivial because nothing about current space access is trivial).
I don't know what part of dying instantly would be painful - that's sort of the point of the "instantly" part. If you watch a video of this process on YouTube it's incredibly quick.
Once again Mozilla does its best: derailing good projects in unrelated contexts for unknown (and weakly supported) reasons.
If it helps read here: https://en.wikipedia.org/wiki/Near_money

Unfortunately this "nonsense" is the explanation that any economist would give you.

Maybe you can be the first one to propose a revolutionary alternative theory, but I haven't read it :)
I know plenty of people using Whatsapp and no people caring at all about its approach to privacy. I have not heard of those other two platforms outside of privacy-obsessed communities. Are real usage data disproving my anecdata?
This isn't wrong, but it is a simplistic model of one layer of depression, which can be a pragmatic way to look at it for some people during some periods, typically the most severe periods. I've suffered from severe depression for my whole adult life, and I am thankful that I haven't had a psychiatrist who subscribed to the medical model as an absolute, in many years. The big picture of depression can indeed be about your life, and no psychiatrist I've seen in the past 15 years has failed to acknowledge that. It's well known that major depression often follows major life stresses such as divorce, breakups, deaths, trauma, other illnesses, and so on. I've never found it fruitful to make it either all about the brain, or all about your life. It's rather a feedback loop between the two. The very nature of subjectivity makes it almost nonsensical to try to distinguish between your mind and your life, from your own perspective. And there's a reason treatment almost always includes talk therapy. I've always been able to articulate what my depression is about. Some people can't. It's just not so clear cut.
Interesting article with great formatting, I hope there will be more! Blogs like this and YouTube channels like 3Blue1Brown make maths more tangible.
Equifax already knows they were in the wrong and are just trying to stop the liability. The big wig lawyer vs yokel scenario doesn't really fit here.
Smart, fast, flexible, unbloated, and with very decent handling of the languages it knows about. Geany's one weak point is the languages it doesn't know. The process of creating a new language definition is confusing, unclear, and finicky, very much a question of trial and a lot of error.

If not for that limitation, I probably wouldn't use anything else for my editing needs.
Unless you're hosting out of your basement you have to depend on someone. I'd rather depend on someone who makes their revenue from hosting websites.

Granted I pay for S3 hosting and Github...
No, the Shanghai subway does not need IDs to use, nor do any subways in China. Buying a ticket needs no need for ID, nor does buying a pre-paid RFID-based card require an ID. The bag-check xray is bottle-neck enough.

Taking the train does require an ID card (or passport), as does taking a domestic flight.
Solar and wind will never be enough to cover all energy demand. It is a common misconception, it is not even possible to reduce energy consumption to low enough that solar and wind would be sufficient.

If we want to stop burning fuel, we must research nuclear. Of course it is unlikely that we would stop burning fuel any time soon, and that's why 15 years is unfortunately not an inconvenient timeline.

If you're interested in the numbers behind this argument I highly recommend the book "Sustainable energy without the hot air".
This is a good summary of the crisis Italian coops are going through.

It's in Italian, but should be easily translated by Google translate

http://espresso.repubblica.it/inchieste/2017/11/24/news/l-er...
> It does the 20% of a full blown IDE's functions that provide 80% of the value.

Does it support code refactoring (renaming variables, classes, moving classes or methods, ...)?
The music of Bach is pretty unique to listen to while coding. The parallel structure of the music lines goes very well for a developer that must coordinate multiple tasks. I discovered bach by myself, and it was a pretty downing task. For curious minds, I would recommend the Goldberg variation, the cello suite and the violin concerto in E major (BWV 1042) as a starting point. At first most of his work may seem like a wall because so much is happening ... but with time you see the light. I remember at first the well-tempered keyboard was like that, but now it just flows so nicely.
It's also a delight to listen to his music on original instruments such as the harpsichord. The music is so much clearer when played on a harpsichord.
From the same epoch there are so many more to discover, one of my favorite is Domenico Scarlatti and his 555 sonatas to be listened on harpsicord played by Scott Ross!
Today I am quitting reddit completely. With some of the time that I will save every day I will listen to a piece of Bach. I've read Gödel, Escher, Bach but never actually listened to Bach.
I gave it a shot because my api was fairly simple and I really did not want to go through the hassle of setting up a server. The overhead turned out to be massive, like half a second per query. So I ditched it for node.
The NHS website has just published an informative and easily readable review of recent research on vitamin D and cancer.

Vitamin D may reduce the risk of some cancers:
https://www.nhs.uk/news/cancer/vitamin-d-may-reduce-risk-som...
Sounds like what you can already bounce off amateur space APRS repeaters already for free. Just would be nice to have a few more.
>4. Put the money slider all the way to the top.

I dont see a slider on indeed. What are you talking about?

How helpful would this be for someone self taught looking for a job?
I'm very sorry, but I do not understand what you mean.
> security checkpoints

The points where bags are scanned? It is annoying. It is a security farce. It does only take a few tens of seconds, less than a minute. Unless in peak hours, then perhaps a minute more, where taxis would take 4x to 5x to take where the subway puts you.
> I've spent a lot of time around lawyers and judges and I can tell you they have absolutely no tolerance for the kind of "well, actually" smart-asses that the tech community excels at churning out.

It's really satisfying when someone articulates so well that nagging sensation that you've had for a long time but failed to expressed. Like scratching an itch. Thank you.
Evidence for either of these claims?
In the UK, the SFO has been systematically starved of funding:

"Its budget has been slashed steadily over the years. In 2008 it stood at £52m, while last year (2016) it was £35.7m"

[Paywall] https://www.ft.com/content/8751e754-6e3e-11e7-bfeb-33fe0c5b7...

More depth on the same report here:

https://www.financierworldwide.com/white-collar-crime-enforc...
Wow! I awoke early this morning from a bit of a bender last night and have a similar feeling of mania (the positive, productive kind). At first I attributed it to a GABA rebound, but thinking back, a sleep fast has historically injected a sense of urgency and vigour.

I have been fasting intermittently after reading Valter Longo's metabolic oxidation research (the term they used for aging research to get it published). I skip breakfast and try to leave 16-18 hours between meals. Have been losing weight but keeping muscle tone almost effortlessly. My skin has also improved. No negative effect so far.

Good interview about I.F.: https://youtu.be/d6PyyatqJSE
I love this idea. And the authors setup seems to have high production values!

Personally, I trawled twitch for a while looking for someone working with C++.

Does anyone have recommendations?
And here is the response to that https://gultsch.de/objection.html
PyCon SK Live Stream
The Goldberg Variations is a good starting point because it evolves gradually to builds in complexity. And it was designed to relax, so it's a perfect companion for a long session of coding.
> The funniest comedy routines I have ever seen by the most prominent comedians are almost always disparaging of a person, group, or idea held dear by many people.

I suggest that says more about you than about anything else.
Of course I can say why, but you didn’t ask that question.

His posts are thoroughly entertaining and well written. They’re long, but true to the title of “blog rants”. You might end up disagreeing with some of his opinions but that’s ok.

And if you’ve read some, and they’re not for you, that’s ok. But no need to shit on other people for enjoying them and claiming we’re in some kind of cult.

At the time they were written, his blog was one of the best in my opinion.
engineers supporting US from

It would be best to re-onshore such roles back to the USA and thereby spare you such annoyance in the future.
There are a bunch of them on PudMed, and not all are that recent. This is what I found on a quick search.

https://www.ncbi.nlm.nih.gov/pubmed/7893848

https://www.ncbi.nlm.nih.gov/pubmed/14522011

https://www.ncbi.nlm.nih.gov/pubmed/16408408
https://www.inverse.com/article/34239-how-many-solar-panels-...
To be honest I have no idea what he means either, but since I had already asked for a clarification once I thought that insisting would be seeing as confrontational and provocative and get me downvoted (like you got downvoted).
Well that’s the appearance you gave by asking the question you did and saying there are only 3 posts from 10 years ago. But you know that.
Behold the Next Generation VR Technology: Part 5 – Locomotion
> [Alice knows] no one (other than Eve) can spoof Bob's identity

If Carol or Chuck can spoof Eves "identity" they can spoof Bobs identity. This can be done in a multitude of technical or social ways.

Is it better to have this than nothing? The problem is that you have to trust your whole infrastructure if you want to do this kind of client side encrypting.
> I think it’s troubling that judges have the ability to hand down sentences far above some established norm

I agree, but that's not what happened in Shkreli's case. The crime he committed really does have a very long sentence.
Sounds like a a web app with voting would be a useful thing. In the UK mental health services have almost disappeared, especially for those who are not extreme. Maybe a list of things to try yourself is useful?
I still use Geany every day! From writing up todo-lists at work, to maintaining my Go, Python and C/C++ projects.

Geany is my absolute go-to editor of choice. Fast, stable and really clean interface. Absolutely love it!!!
ML PROJECTS: things to know before getting started.
Been dealing with these things over the winter. I'm both glad and creeped out by having read this now. I have a method to kill them that works and doesn't smell, but is quite annoying - I shoot them with my salt gun a few times. The real key is to get a near-range shot to the underside. Sometimes It takes a number of them, but I can usually do it in 3. One to knock em down from their perch, one to stun, one to kill.

The salt it leaves behind is annoying to clean, of course, but I've found it to be quite effective.