skysight-inc/HackerNews huggingface dataset:
Here is the actual paper, with abstract:
https://www.nature.com/articles/nbt.4071

Major things that are interesting just from the abstract:
1) their targeting dna aptamer binds to nucleolin (how this isn't binding to the nucleolin in normal cells is beyond my knowledge, but my guess is that the protein is expressed somewhere other than the nucleolus of the tumor cell).
2) Doesn't seem to affect mice without tumors, so a good thing?
"Shipped and sold by Amazon" doesn't mean jack squat. They use their warehouses to commingle inventory from many individual suppliers.
Ok, who can make this happen? Let’s show them we are not useless.
As a Tcl fan, I was just clowning around; but as a matter of curiosity, there do happen to be a number of possibly-credible Tcl web frameworks. I haven’t done any homework on any of them. https://wiki.tcl.tk/40649
They are up again, since about an hour: https://twitter.com/sfnet_ops/status/970143157307559936
It's begun: 'First' IPv6 denial-of-service attack puts IT bods on notice
To anyone who isn't aware, there is a huge world of car hacking. There is of course the basics like getting an expensive air filter (pointless), and it goes all the way up to welding up your own custom car. The more common mods are things like tuning your suspension, replacing your engine with a more powerful one, or upgrading your differentials. It takes a wide range of skills, including welding, machining, panel beating, plumbing, and electrical. You can very easily nerd out on this.
My man! Let them have soap!
How about Tesla drivetrain in a stretch Vanagon?

http://cafeelectric.com/stretchla/about/
Is there any mention of his contact info?
I don't know if you mean literally sounds awesome ;). It's absurd (in a good way) how the RC-car electric sound belies the actual acceleration.
Women tend not to like to admit it, but the reality is that marrying a rich man is a common "career" ambition for many women globally.

Heterosexual men do not have that same option.

As for why an already wealthy woman would likely choose an even wealther man: I'm not sure how prevalent this is. If this does happen, I think it's an effect of the culture where men are expected to be the "provider", pay for everything, etc.

Men are expected to pay more for everything even in modern, progressive/feminist countries like Sweden. Last time I lived in Sweden, my girfriend at the time — well educated and quite progressive — expected me to pay more than my fair share even though she earned more than me. This is something you must do as a "gentleman".

Come to think of it, I had a girlfriend in California and she was the same.

Thinking more about it, dozens of examples are flooding into memory of wealthier women expecting me to pay more.
I don't see why there is such an agitated response to the term "fudge factor" (I see downvoted comments, several knee-jerk defensive replies, etc)

It's important to embrace one's ignorance -- especially when we're at the absolute frontier of human knowledge. If you've seen some of the calculations involving dark matter's effects, calling it a "fudge factor" is a fair characterization, and one that is acceptable among physicists. We postulate a component with certain properties that fudges our calculations in just the right way to match some indirect observations (circumstantial evidence).

We still don't know what is the thing which produces the behavior we expect, and what its properties might be. We're still seeking evidence that would seal the deal, so to speak. It's true that several such fudges historically turned out to be profound stepping stones, but till we get there, "fudge factor" is absolutely honest.

I'll leave some Richard Feynman quotes here:

* "The first principle is that you must not fool yourself — and you are the easiest person to fool."

* "I can live with doubt and uncertainty and not knowing. I think it is much more interesting to live not knowing than to have answers that might be wrong. If we will only allow that, as we progress, we remain unsure, we will leave opportunities for alternatives. We will not become enthusiastic for the fact, the knowledge, the absolute truth of the day, but remain always uncertain … In order to make progress, one must leave the door to the unknown ajar."
Computers used to mine cryptocurrencies stolen from data centers in Iceland
So if the culture was non selfish, why would capitalism be a problem? The wealthy capitalists would use their power for good. Thus, capitalism is orthogonal to the issue.
I maintain a puppeteer-as-a-service repo here: https://github.com/joelgriffith/browserless. It’s pretty feature rich at this point, allowing you to specify concurrency, sessions timeouts, and comes with a robust IDE (which you can play with here: https://chrome.browserless.io).

I’m working on building out a serverless model, which is the holy grail of headless workflows, but it’s a bit more challenging to operationalize than one would think.

I’m hoping that these efforts will lower the bar for folks wanting to get started with puppeteer and headless Chrome!
Also, it was an employment opportunity for many maidens, ie., not yet married women who needed some income might do laundry for people of greater means.
But what are these huge consequences people are alarmed about? A very slow increase in sea level rise over 100 years can easily be addressed. Warmer climates will mean more vegetation and a more habitable planet. Why is not more attention focused on the benefits?
I’m bitter about FAANG’s tax avoidance as much as the next guy, but these people are also under the protection of our laws. No one deserves to be shot at for working with Google; shouted at maybe, but never shot at. As a country we can’t accept that, and in any case, everyone on those busses does pay taxes.
Back in University, we had one guy in the dorms who said his Uncle Bill put a Miata engine in an MGB. We were contemplating how that would even remotely be possible; looking up pictures of forums boards of both engine bays.

"Well I guess, if you remove all of x, y and z and made custom mounts..."

We later learned this guy ones one of those bullshitters who would lie about everything; told us he was in the national guard and hat to shoot rubber bullets at people looting stores after tornadoes. He was our age and had one of those civilian IDs they give military family members.

Next semester we ask the guy if his uncle will bring his MGB to the car show we were putting together. "Oh he sold it." .... right ...

Anytime we had some crazy idea for our cars. "I wonder if I could convert my mom's Maxima to a 5spd," the respond would always be, "I BET UNCLE BILL COULD DO IT!"
It's worse than that, because GDPR in of itself, will not technically stop useds from inadvertently blasting data to any service

Decentralized services that EU citizens use will be even less in compliance as data is shared and copied between nodes by default. Sure block a few servers by spending more resources to find/go through the legal moves than it will take for a dozen more to pop up… see torrent sites/software and how people are monetizing such, because that will be the future… laws like GDPR only make such even more attractive.

And lets just set aside that nation state actors that are routinely compromised will still collect this data that will leak on to the internet… lol

These laws are analogous to those that were against the printing press… fighting the tide of reality where it's easier to do nothing than to contort something to fit a luddites dream of personal privacy provided by the state mandates (on top of building a functional product), without having to do anything oneself to protect ones interest, in the age of deep packet inspection, 0day-exploit-exfil-as-a-service, and metadata drone strikes.

Would be more effective to just make it law that users have to plug a black box onto their devices/networks so it can just filter non GDPR colored bytes lol
Here's an idea: Don't invade someone's privacy like that.
Have you seen _my_ startup (https://browserless.io/). The stability part is something I’m trying to solve once and for all with this project.
The US needs laws and a DOJ that can put an end to this kind of market power abuse. What Google and Amazon do to each other publicly they do daily to millions of individuals and small businesses that are too weak to retaliate.
Thomas Mann is a giant of European literature, a Nobel Prize read in universities all across Europe. Chances are it's compulsory reading in German high schools in some way. The Buddenbrooks alone will probably sell a good amount of copies each year.

Heinrich Mann was a very important figure during Weimar. Again, chances are it pops up in compulsory reads.

I honestly don't know Döblin, but looking at how his most famous book is described, he seems to be another key read about the Weimar years - again, likely compulsory at school in Germany.

Schoolbooks make a lot of money.
Oh, I hadn't read anywhere that Google has changed its tax strategy to increase its effective rate beyond the 2.4% they've paid in recent years. But maybe so.
well done everyone. we have made amazon the gatekeeper of the consumer market. don't make Baron Amazon angry or he will have you run out of town.
Which means a surplus of spare parts because it's too expensive to repair a salvaged car.
httperf.
I would say it's reality.
No, but individual sites have sometimes published their own data about, so we know it happens and is expensive, but not the aggregate numbers.
Remember that High Sierra update that left a nice privilege elevation bug for like a month? That never happened...
If you never admit to it, it never happened. Apple's security philosophy.
Point a is covered under GDPR. If you have German on your website their courts have jurisdiction. The language is so vague that they will have jurisdiction over all the world when it comes to PI privacy laws.
Doomsday scenarios in the public imagination. For instance, I saw a commercial in a UK theatre that showed people drowning in city streets due to global warming. That's ridiculous. I've heard claims the Maledives will be submerged in X years, even though the Maledives are coral islands that will rise with the sea level increase. Then I see lots of conjecture that this or that tragedy is attributable to global warming. In general, there is a lot of alarmism, but it is hard to pin down what exactly the problem is. Maybe you can clarify. What is a specific problem we face that is directly attributable to global warming?
Autorotation is an immutable property of variable pitch rotors. Whether it can land properly without hurting a person is a physics/biology problem

3rd answer down :)

https://aviation.stackexchange.com/questions/37360/can-a-pas...
Treat it like investing. You have a limited fund (of time).

Some things are high risk, high return. Some low risk, low return. The returns are higher the earlier you invest in them. Like someone who knew how to do cryptocurrency 2-3 years ago probably makes much more money than someone learning it now.

I feel like it's still a bit early for AI, in that the tools haven't matured yet, and so you'd end up paying more (time) to do so.

You don't want to invest a little into everything. Sit down and spend some time seriously thinking it through. Then pick a few things and focus.
> Is "amount of time and dollars spent" the only part of your purchasing decision matrix?

No, but it’s a big part.

> Something to be said for supporting jobs in your community, keeping money in your area,

The comment here was about “major retailers”. If you want to buy from a local mom and pop shop, awesome. There are great reasons to do that. If you’re going to Best Buy, those reasons pretty much evaporate. That money doesn’t stay in the area and the jobs probably aren't better than UPS provides.

> bumping into people you might not have seen as much otherwise

No thanks. People say this because it sounds good and is hard to refute but I don’t care a bit about bumping into people at the store. I bump into someone I care about at a store less than once a year. Interacting with people in a retail store is not generally very rewarding. They’re almost always either salespeople or strangers. People in stores are better referred to as crowds.

> Stores can also be great for discovery. It's a lot easier to play with laptops at Best Buy than it is to research how the keyboard might feel online.

Sure. There are reasons to buy in person and this is a good one. “Need to physically hold to evaluate” is not a common attribute of most of the things I buy, though. And generally free return shipping solves for this when I do need it.
It would probably make more sense to fly a drone with FLIR over the area.
There is an established treaty for handling this particular issue. The court in question has decided not to follow that treaty.
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is headless chrome's API just as easy to work with? Taking a screenshot or saving a page as pdf is stupid simple with phantomjs
I'd really like to use a tool like Anvil, but my experience with one-click magic solution tools is that it oftens greatly limits the customization options or doing something outside what it's built for.
>There's no technical reason Chromecasts can't be set up by Kindle Fire devices, it's an intentionally-implemented block by Google.

This is some high-level misinformation being spread on your part, and not the first time you've done this on HN.

Chromecast is an open SDK - Amazon has the power to implement it at any time: https://developers.google.com/cast/docs/terms
Or more realistically arbitrary people trying to get access to passwords and cc info.
"I like the speed but miss the vroom," she explained.
Bear in mind, this is merely an escalation (mind you, a violent one), of something that's already been going on since 2013. People have been staging protests in front of these buses for a while now.

https://en.wikipedia.org/wiki/Google_bus_protests
Ads are a feature which allow the various companies involved to provide content for free to the consumer.
My data point: I suspected that I'd work in software when I was about 10, and knew that it's what I'd go to college for when I was 15. If my wife was the breadwinner, it's what I'd still be doing (granted, less software that's useful for business, more emulation, game modding software, and reverse-engineering game engines). The money's a definite bonus, and it has made our lives much easier, but it's not why I chose my career.
I wonder how much of it is how they were managed. I'm a man working in a technical field, but I tend to be more emotional/intuitive than other people I find in Engineering roles(yes, even women). But other engineers tend to assume that I'm motivated by the same things they are when that's patently false. I gravitate to the kinds of roles that your four examples gravitate to because there's more room for intuition and more opportunities to connect with people there than in software engineering.

The best manager I ever had was a woman, because she managed by connecting and by learning about me. Contrast this with the male engineer managers that I've had, who've all been average or sub-par because they assume that the only correct way to motivate me is to give me more money, and they assume that all I want to do is work on "interesting" problems. In short, they don't take the time to actually learn who I am or to connect with me, they just assume that I work exactly like them. It's a very cookie-cutter approach to management that fails to create diversity.

If your friends' management is similar then it doesn't surprise me that they left the field. The job I'm leaving made me question on a weekly basis whether I belonged in software engineering despite management telling me I was a good engineer repeatedly. And I'm a lot more interested in the types of problems UI/UX designers solve than I am in solving traditional software problems.

Luckily I'm moving to a company where management is less "technical" and more intuitive/connected. If it pans out I'll stay in the field.
HTML5 games seem to be working fine at Disney which is about as mainstream as it gets:

http://lol.disney.com/games

I'd say your experience is not universal.
In that case, your customer is the "controller" and you're the "data processor". The whole GDPR is written with such B2B relationships in mind.

Chapter 4 is specifically all about that.
Article 28 specifies the situation for the data processor: https://gdpr-info.eu/art-28-gdpr/

And well, basically your customer has to tell you all of these things in the contract. (Article 28 Section 3)

Furthermore, if you yourself want to pass that data on to another data processor, you have to notify the controller of that and tell that data processor those things that the controller specified in the contract, too.

It's also in the responsibility of the controller to select data processors that implement "appropriate technical and organisational measures".

That's a term that you should also find plenty of literature and discussions on. The GDPR specifies somewhat in its recitals: https://gdpr-info.eu/recitals/no-78/

And you might also want to get certified that you are GDPR-compliant, just to make it trivial for customers to see that you can implement those appropriate organizational and technical measures.
This is funny, as I assume that spin is an effect of the force of gravity. Swinging and pendulum spin is just what happens in nonlinear dynamical systems. It's called ringing in sound engineering. You only need three bodies to simulate that. A binary pulsar will rotate. Crazy idea ... what if that's not a two star system of many neutrons, but just two neutrons moving really really fast, thus becoming heavy, bending space and thus appears to glow, because it act's as a lens for light.

Is that the holographic universe?
Access is controlled by limiting the supply of aircraft via regulations, not by limiting the supply of pilot licenses. It was mass production of Model T's not driver licenses that gave citizens freedom. The reason getting a pilot license requires aircraft rental is because access to aircraft is restricted to the point that few people have a family member with an aircraft that can be borrowed.
This is mostly marketing. You can scale to infinity only if you're app is architected in a very particular way and you're properly using the underlying primitives (be prepared to shard, cache, and queue everything at some point; try to put thought into where your demarcation points will be, it will make future decoupling less painful). Even Aurora Postgresql and Mysql only scale so far.

One click it is not.
If America doesn't get a handle on wealth disparity we're going to see a lot more of this, and certainly worse.

You can say that attacking the buses the wrong thing to do, but the moral high ground isn't going to stop it from happening.
Coinbase hit with 2nd Class Action for violating Unclaimed Property laws
Better than right after release.
It's worth noting that while monads themselves naively introduce a data dependency, that doesn't necessarily force evaluation order. If the compiler is smart enough and sees something like:

foo >>= \_ -> bar

It is well within its rights to evaluate bar and then foo, or do both in parallel, or not evaluate foo at all, as long as it can guarantee that the resulting value is the same. The big thing it needs to be careful of is not to introduce nontermination.

What makes this do the right thing for effects is what values of type IO actually are, and what bind means specifically for IO. It's helpful to think of an IO value as code in another (imperative) language. Bind takes two fragments of code in that other language, and stitches them together into a script that executes one after the other.

The key thing is that the order in which you compute parts of the script is entirely orthogonal to the order the commands appear in the script.

In Haskell, evaluation does not cause side effects, period. `main` is a value of type IO, which is executed when the program is run. The effects of that execution are independent of how the value `main` is computed.

Obviously, the computation itself takes time and space though.
It's an unfortunate term used for Microcephallics in Pakistan, who are bought and sold as virtual slaves, forced into begging:

https://www.youtube.com/watch?v=6kxPiRcw3oc

https://www.youtube.com/watch?v=Y1WlHl6DNas

The condition itself is often (though not always) caused by a recessive mutation, which consanguineous marriages--ever popular in Pakistan--significantly increase the risk unmasking:

https://en.wikipedia.org/wiki/Microcephalin

http://blogs.discovermagazine.com/gnxp/2010/08/the-individua...
This is absolutely true. Here's one of Jim's other builds that's sitting in our office. It's a steam powered car on a Model A frame. He and one of our other engineers are getting pretty good at this.

https://www.instagram.com/p/BbVdaa_gKB2/?taken-by=jimmy.buil...
If home automation is their goal, then why doesn't Amazon open an API for making automated purchases? They can sell more through their marketplace this way.
True that the history of physics has had many "fudge factors" but truths - mmmhhh.

I think what we have seen is that our explanations of how the universe works has changed and sometimes those changes have meant a radical change in our perspectives. However, truths are much more the domain of philosophy and religion.
I agree, a crime is crime regardless, but it raises a question nonetheless.

Additionally, if I as an individual were to go to the police claiming something similar I suspect they would tell me to claim on insurance, and to try to make myself less of a target by not advertising my identity. I doubt they'd be running fake cars on my commute to try and catch the perp.

Maybe I'm wrong, but the police seem to be going the extra mile (quite literally) in this case.
Alison Wolf's book, "The XX Factor," examines time use diaries to gather data about which domestic tasks women spent the most time on, and the conclusion that she ultimately comes to is that while washing machines did make the process of washing laundry more efficient, the end result of these efficiency gains isn't that women spent less time doing laundry, but that people started doing laundry more often. So the washing machine made us more hygienic, but it didn't really free up a lot of time for women who performed those sorts of domestic tasks.

One Alison Wolf's main conclusions is that the inventions that actually resulted in women spending less time on domestic tasks were mainly those relating to cooking and food preparation (such as TV dinners and fast food in the 1950's), because the result of a x10 efficiency gain in food preparation isn't that people start eating x10 as many meals, but that the same number of meals get produced with 10% of the time investment.
BMW are playing canned engine noises through speakers in their newer cars, for people who enjoy engine sounds.
The 350mph jet school bus was kind of cool also

https://www.youtube.com/watch?v=qvAPzGCqVG0&feature=youtu.be...
I found your same post from last month's thread, sent my application and got no reply.
No more so than if they didn't participate. It's generally suggested that if someone sues you in a jurisdiction that you care about, you show up to defend yourself. Otherwise you'll simply have summary judgement entered against you. Now, in this case since the plaintiffs won, it probably wouldn't have been any worse—and likely cheaper due to lower legal costs—but they couldn't know that going in.