skysight-inc/HackerNews huggingface dataset:
>This is setting the bar rather high, no?

I understand what you are saying, but "signatures of positive selection" has a very specific technical definition and associations are not it. It means allele fixation in a population due to quantifiable selective pressure (or quantifiable selective pressure proxy statistics).

When it comes to quantifying evolution, I want to see them attempt to validate molecularly or an attempt to infer selection mathematically. For example, show that the SNP is non-synonymous and causes protein change, and then rescue. Show that it's in a promoter, splice site or enhancer and rescue. Show extended runs of haplotype homozygosity thats significant. Show a selective sweep in the region, or a peak of LD. Show a higher than expected diversity in the target gene between species, and a derth within-species. Run PAML or do some comparative genomics to show the SNP being novel and adaptive. Show me a skewed allele frequency spectrum. There are lots of ways to show positive selection that are outside the toolbox of a lot of GWAS people. HAR1 for example was an absolutely beautiful story of a bioinformatic prediction of adaptive evolution, followed by amazingly solid functional validation : https://www.ncbi.nlm.nih.gov/pubmed/16915236

Alternatively, this paper is a tour-de-force of detecting adaptive evolution bioinformatically. https://www.nature.com/articles/nature10944

If feel like there is this big disconnect between the world of GWAS and the world of population genomics, and this paper was really frustrating because I was open to the hypothesis but it fell flat on the delivery.

Anyway, if you want to know more, check out https://www.ncbi.nlm.nih.gov/pubmed/16285858 this review. It's by one of the eminent population geneticists in the field and really covers the different signals of selection well, and intuitively.

> It is at least a step up from people who come to me (bioinformatics) and ask me to use my divining rod to guess what their SNP 100Kbp from the nearest gene might do.

Hey, I feel you. I know the struggle all too well.
Aren't they working on that?

I mean there is stuff like kinesis streams, AWS IoT and Lambda@Edge
I remember the early days of Tinder when they would allow unauthenticated API calls from anywhere and returned location information accurate to a few feet.

This doesn't seem like much has changed.
Just a minor technical quibble (because that's what HN is for, after all)--"too cheap to meter" refers to the expected cost-effectiveness of fusion power, not fission, and "too cheap to meter" doesn't necessarily mean that power is free, just that the costs of power delivery are dominated by the delivery infrastructure rather than the generation of the power in the first place. In other words, you'd pay a flat rate per month for unlimited power to keep the power grid up and running.

Fusion power would also be cost-effective enough to literally turn CO2 and water back into hydrocarbons, desalinate ocean water for large-scale irrigation, sustainably produce nitrogen-based fertilizer from the air, and otherwise solve virtually every sustainability problem we face or will conceivably face for centuries. (The rest can be solved by harvesting mineral resources from asteroids instead of the Earth's surface, but that problem can be solved through better orbital infrastructure, which turns into an energy problem.)
The "deregulation" of Ajit Pai's FCC is just picking winners. It's hands massive market advantage to an oligopoly of telecom companies at the expense of everyone else.

All markets are constructed. Markets constructed by self-professed "deregulators" seem to be particularly skewed and corrupt.
I’m only referring to mainland. 1980s obviously building up to 1989, where there was a huge regression after Tiananmen. Then it started opening up again, working it’s way to the Olympics to show the world that China was no longer closed socially and economically (we could even access Facebook and gmail back then, note that CNN was blocked in 2002 but not in 2008 and not today). After the Olympics, everything was cut back: more censorship, internet great fire wall blocking, crackdown in minority areas, and so on, building continuously until today.
Yes. You just need a tiny wrapper to convert your Express endpoint to a API Gateway Lambda.
It's interesting they have invisible small white text under images with embedded text so that you could do a text search.
Astu (अस्तु) is imperative, asti, (अस्ति) is what would be used.
10 Basic Interaction Design Principles to Boost the UX Design
Your concern is unnecessary. Real issue is that PIN lock is not secure enough in first place. Even if Chinese or US government doesn't have the PIN they can still decrypt a phone given the abundance of computing power they posses.
Eclipses git support:
right click on a file, show history, navigate between classes, notice eclipse hanging every time you switch between classes because it’s spending unreasonable amounts of time loading the git history while blocking the main thread every time with no caching whatsoever

Facepalm

I run into thousands of moronic things like that on an average work week
That is a completely different beast. I was talking specifically about uploading and downloading files I intend to open.
segwit will indirectly lead to centralization... when lightning network gets fully implemented
Isn't Lambda just the glue?

I mean there is also Kinesis Streams, AWS IoT and such.
Not sure what is new here at all. They require full 3D camera vision/processing, only support pneumatic picking, the speed is low, they require a third party expensive general industrial robot arm and a full 3D scan ahead of time, the motion envelope is large, and the price is high.

We have a better in-house solution we developed over the last few months which is higher speed, does not require a large motion envelope or full 3D camera vision/processing, doesn't need 3D object scans ahead of time and works out cheaper.

If anyone enjoys this stuff we are hiring here in Shenzhen... http://infinite-food.com
Cool. So if it’s in the same table, it’s just as secure as one salt sitting in a config file. When the table gets leaked, so does the salt.

Also, is he? More than one salt sounds too complicated for him.
Your income is in large part due to the environment created and protected by the government, even the parts you find distasteful.
If you feel guilty about that, you can donate your income to charity and deduct it from your taxable income.
I guess I was imagining it when I used the features myself internally starting in 1989 or so.

Distributed client/server was first implemented in Informix-SE in the late 1980s but was more widely used starting with Informix-OnLine. Version 5.0 (general release in late 1991) had two-phased commit, but I think 4.X did also no later than summer 1990 because I did some onsite diagnosis/fixing for a major client then.

There are references to OnLine 5.0 features and general release in the Informix 1991 Annual Report[0].

[0] http://archive.computerhistory.org/resources/text/Informix/i...
Dropbox was an unusual case in that Drew built the product and got into YC before getting Arash to join. I guess maybe a lesson is that you can invent and code up something like the early dropbox on your own but it's useful to have a cofounder when employing a bunch of people and building a company?
Yes sexism is alive and well. I always assumed it would die with my dad's generation. But no.

I assumed geeks would be the last kind of people to be sexist, but no.

I don't really have a solution, although things do seem slightly better than 50 years ago.

The only thing that seems to make a difference is women shouting to be heard and telling their kids to be less sexist.

It clearly takes generations to change.

Not that that helps you. But I do at least respect your comments.
There is a way to do this in Tensorflow, where you try to expand your training data images by altering them, moving them around, etc. However, this is not used with large training sets.
In a just world, any musician, actor or artist that 'steals' time from an audience to espouse political opinions should be subject to unlimited free file-sharing of their content.

Yes, I like that idea.
UTorrent: various JSON-RPC issues resulting in remote code execution
I learned on just basic about a decade and a half ago and it was my segue into becoming a developer
The executive team each has a base salary of 400,000. That's a lot of money, with a 65% target bonus. That is so much money.
I disagree. Read day 2.
If Apple and peach had very similar word vectors, an English apple and a French peach would have the same too. And there is a risk of mistranslatuon. How is that situation handled?
It is true that money doesn't come out of thin air, but it doesn't always get passed on. I worked at a place that had some billing issues. It wasn't cheap to correct, but it was the correct thing to do. Where did the money come from? Out of the next few months of profits. Things were tight, but customers were happy.

If there were regulations forcing an expensive audit, I'm sure we would have built that into the cost of business and passed it on - but not the results of our mistakes.
BitTorrent client uTorrent suffers security vulnerability
Curious coincidence how that sounds like 'it's so' and 'itsso, eh'!
Loved that pun from Baudolino by Umberto Eco:
"I know, Master Niketas, that the center of the universe is your city here, but the world is vaster than your empire, and there's even Ultima Thule and the land of Hibernians. True, compared to Constantinople, Rome is a pile of ruins and Paris is a muddy village, but even there something happens every now and then. In many vast, vast regions of the world people don't speak Greek, and there are those who, when they want to agree with something, say, oc."
"Oc?"
"Oc."
"Strange. But do go on."
This is very common. It's an easy way to improve accuracy on a model with a fixed amount of data. They typically crop the image as well as rotate and scale it in order to get a larger data set.

It does make the model more robust, but doesn't seem to help much with finding adversarial examples in the model.

Generating adversarial examples and training on that might be a better approach to solving this.
Never heard of bodypump however I would recommend body weight exercises. A lot of injuries come from muscle imbalance which happens abruptly when muscle is gained quickly.
I recently saw a yellow banana-man in a moshpit at a metal show.

Don’t put breaking expectations past humans. We are adversarial by nature.
multiple times?

I that because the landlord filed a form but the tenant didn't file a form to match?
Interesting subject tainted by crappy narration.
Thanks! We've updated the link from https://choosetoencrypt.com/news/tinder-lack-encryption-rais....
Rowing is also an exceptional full body exercise to do indoors.
Would be intersting to see relapse rates for those doing another tour.
You have to remember that there’s a large group of people to whom $300 means little more than $5. That’s the target demographic for these products, and to them, there is no predicted risk in spending $300 on chocolate. In other words, they have no problem spending the money because there will be no pain if the product disappoints. The money just doesn’t matter.

Knowing that, you just have to figure out how to reach them with the promise of a novel, luxurious experience.
I had to look up OODA, because I had never heard of it. But I have to say that this has been a personal strategy of mine as long as I can remember. And I think it has been mostly fueled by a constant desire to learn. Just sheer curiosity.

I think building up a massive collection of mental models and consciously linking new concepts to previous knowledge where it might be valuable has allowed me to quickly grab ideas from varying sources to solve problems in novel ways. In my opinion, the enabling factor to this strategy is to continually amass a wide range of theories, ideas, strategies, etc and imagine how they might help each other. Like building up a great lego collection. You have all these parts from various sets, so when you want to make something new, you have all these pieces that didn't come together originally, but you can create novel solutions with.

Having all of these strategies in your arsenal, allows you to more quickly iterate on actions, while continuously learning more about your problem, allowing you to zero in on a best strategy.
Facebook and Google Struggle to Squelch ‘Crisis Actor’ Posts
If you have the cash there are some great electronic resistance direct drive indoor trainers you attach a real bike to. Search Google for zwift enabled trainers (brands like tacx)
WebAssembly does not. However, for UI presentation you would want Servo and Stylo.
Bitcoin or not, if you bought it with money and sold it for money you have a gain or a loss, in money. And if you bartered it for non-money tax laws about barter apply.
A question from ignorance (I don't have any of these devices), but couldn't the weirdly unique accent problem be solved by reading a list of standard vocabulary words a few times to the device while training for accuracy?
Thank you for your feedback! (author here)

Our intention is really to provide a sound comparison. I think we agree that these kinds of comparisons can be hard given the constraints (e.g., lack of available technical information on TPUv2 or public implementations of optimized models for certain architectures). As I stated elsewhere, we are collecting all of the feedback and will run additional experiments.

If you know of an implementation of a mixed-precision/fp16 model that you'd like to see results for, please let us know! I may also reach out directly to you for that if you don't mind.
Mark Cuban says studying philosophy may soon be worth more than computer science
A fourth option, for those in physical datacenters who do not need to run active/active, is of course to eschew network replication entirely in favor of a RAIDed JBOD shared between two or more servers. If you have the hardware, this is often the easiest to configure, and the most efficient.

EDIT: I should clarify that, like the other HA solutions in the article, of course you need to couple this with a backup solution, like periodic dumps to S3, such as the article suggests.
Federal taxes apply nationwide.
you can't just enact regulations that take place immediately

For example, look at the huge volume of new regualtions that weren't even published until after the 2000 and 2016 elections (the final 8 weeks of 8-year terms). If you're waiting until the final 2% of your term to make new regulations that only affect your successor, those regs warrant a critical eye.
I'm a big advocate of strength training, and becoming strong has impacted my life in ways I never expected before I was strong. That said, it's likely that when it comes to impact on memory, aerobic exercise is the way to go. [1]

Only somewhat related, but besides finding this to be anecdotally true (big improvement in memory since I started running), I've also noticed that running certain routes--or perhaps past certain landmarks--will dredge up a memory that I've somehow linked with that specific place.

[1]https://www.health.harvard.edu/blog/regular-exercise-changes...
They are both trying to make things more simple, for themselves.
Writing some test cases with proper method naming will greatly mitigate the need for code comments
More power to you! You should know that Millennials are not the only victims of the current system. I'm 71, and I have to live in Mexico because I can't afford a home near mass transit and a culturally vital environment.
Palantir Must Turn Over Internal Files to Investor
'Serverless' has to be the stupidest idea I've seen in a long time. How could it POSSIBLY be a good idea?
I am sorry you are being downvoted as I live here and fully agree with your "same as anywhere" notion. One great example of this "everywhere else" is the EFF domestic surveillance post today: https://news.ycombinator.com/item?id=16446716

I do think that China would look at foreign residents or corporation's data, but they would really have to have a reason to care and this is a kind of moot point since if you had any secret data you cared about, you wouldn't be trusting third party cloud storage anyway.
I got my start with programming in QBasic. Now I work at a Prominent North American Enterprise Linux Vendor. FWIW I don't write much code that gets merged into anything important, but I wouldn't be working in the tech industry at all if it weren't for the curiosity QBasic sparked in me twenty years ago.
>7. "It is my understanding that..."
That sounds like amoral sociopathy. Whatever works for you...
> those are things that can be fetched at build time

At least for Linux distributions, the package builders are normally not allowed any network access; this was an issue for packages using Rust before cargo-vendor and the introduction of a flag to cargo to never try to update the lockfile.

Not allowing network access for build hosts is probably not limited to Linux distributions, so this use case will have to be addressed sooner or later.
There are a lot of high QOL countries with specialised tax systems that don't tax all income.

However, since the US government taxes your entire income above a certain threshold globally, there's not much you can actually do to optimise taxes.

Nearly all non-US citizens can move to a country that does not tax capital gains (on crypto) to avoid tax.
Well, AlphaZero doesn't use expert knowledge of Go, specifically, but it still uses Monte Carlo Tree Search, which is a very strong encoding of what matters in games in general, so I'd say, no. It's not learning from nothing.
The better response to this situation is to vote in a different government, not to beggar our nation through tax fraud.

If you don't like what our government is doing (and I'm with you on the examples you cite), put in the time and $ to make it different.
Personally quite shocked that anyone in this community would endorse FBs behaviour in general by being users.

A closed version of the internet controlled by a corporation? We should be yelling from the rooftops not nitpicking things like this story
The point of that section of an S-1 is to try and disclose every possible risk so that investors can't accuse you of hiding risks later on.

So, when quoted out of context it sounds really extreme.
LoL. Many engineers at Google make more than that with their RSUs.
What do you mean “the same in the grand scheme of things”? By what metric?
Huh, I'd thought Lambda covered smaller components than those asked. TIL.
the economist would say...

"affordable" is a opinion.

the market price is the market price, if you want one you have to pay more.

you are not entitled to a good at the price you think is "fair"
Honestly, this comment depresses me so much. We've all got Stockholm Syndrome.
Pretty sure tax software rounds every entry (that means input data and "worksheet" numbers), not just the numbers on the final forms. Also there are no "intermediate" numbers in tax calculations as each step is always an elementary arithmetic computation (+,-,*,/).

However, if you do things by hand there is some ambiguity whenever you have a choice to bundle or unbundle accounts, because if you enter them separately, you've rounded before the sum, but if you enter one total, you are supposed to round after the sum. You can save a buck here and there if you want.
Lucyd – Fundraising Scheme Wrapped Around Worthless AR Patents
We’re all talking about an announcement that Google Assistant is supporting over 30 languages.
Why would you pay for what is essentially sophisticated blog spam? The quality of 95% their 'journalism' is abysmal.
was A Fire Upon the Deep not good?
Hacking Der Spiegel's paywall
I just started using cron to keep my cloud functions warm at a cost of pennies per month. It feels like a strange ceremony to let more knowledgeable people game the system. Even figuring out the time that your functions go 'cold' is a secret handshake you can't find in proper documentation.

I'm curious what's going to happen when everyone else does this too. It goes without saying this isn't the intended use for the price they've set and it's also apparent that >75% of customers will, likely, choose to make this performance optimization before going to production or after complaints of bad latency.

Also it is a bit scary that even with keeping a single server warm, you still pay the cold startup penalty on subsequent scale-ups. Afaik, no cloud provider has claimed to have 'solved' this (yet more secrecy in how the platform is managed)
Even in principle, this is similar to saying a bridge is "too cheap to meter". There's no fuel cost, but it can certainly take a long time to pay for pricey infrastructure via tolls.

I don't see why anyone would charge a flat rate for unlimited electricity when you can pay off the enormous debt faster by charging market rate.
Other systems might work the way you described, but in the US (and England, whose legal tradition the US inherited), judges certainly do make new law.
As long as you understand that "you" don't exist, you are just fine.
I really feel that any article that quotes the founding story of a startup/company/product is just being plain lazy and it's an instant turn off for me.
Big deal, you can do the same with milk: https://youtu.be/ToZ4Z9qlb4k?t=29
I did ask myself and I have a plan for each of those things. Except for FB, because I don’t give a damn.

Basically the plan is to own your domain name, and build things around email that can be moved to any provider.
I didn't want to sound offensive at all, sorry if it happened. I agree that it fixes nothing in terms of curing sexism, but if it could fix the problem of not getting paid gigs I would try it, and I know several cases when it works for female freelancers. They just have male handles and don't contact their clients in person (offline or with voice).
Just a random guess, but they may have been hunting for a self-incriminating admission of drunk driving. I got pulled over for speeding once, and the first thing the cop asked was "Why do you think I pulled you over?". I shrugged, and said I had no idea. He claimed I was speeding, but let me off with a warning. In another instance where I got pulled over for speeding[1], the cop told me as much, but then asked how fast I thought I was going. I told him 65 (which was 10 over the limit of 55). He claimed that I was going 70 (15 over 55), but wrote me a ticket for 65 in a 60 zone (5 over, notice that he went with the speed that I claimed, but changed the speed limit in my favor). Apparently the fine varies based on the amount over the speed limit, so he basically gave me a lower fine. My hunch, is in both cases, they were just looking for admission of guilt.

[1] Just so people don't get the wrong idea, I am generally a very cautious driver, there were the only two speeding related encounters in 15+ years.
Nice! How long does a post remain online before you need to do any cleanup (inactive pages, etc)? I didn't see mention of that in the faq/terms.
That's a weird reason to downvote. Most people don't know what either of those terms means.
Beinecke Library Digitized Gutenberg Bible
IBM's SMIT did this, and did this 25 years ago (although it generated shell scripts instead of Terraform/CFN/Ansible/Chef/Salt/Etc you mentioned). You could have SMIT just go ahead and do whatever, or you can have it show you the sequence of commands it would do.

And it worked both from the command line and the GUI. I can see no issues with it having a web interface as well.
If you had really perfect sound/airflow control you could maybe get what looks like a movie hologram I guess, if you really miniaturize each light
Dropbox needs to be seen like Atlassian, not Box, to avoid a downround IPO
Thanks for the correction. Botai is a lot easier to remember and type for me I guess :)