skysight-inc/HackerNews huggingface dataset:
Histatins are the major wound-closure stimulating factors in human saliva as identified in a cell culture assay

ABSTRACT

Wounds in the oral cavity heal much faster than skin lesions. Among other factors, saliva is generally assumed to be of relevance to this feature. Rodent saliva contains large amounts of growth factors such as epidermal growth factor (EGF) and nerve growth factor (NGF). In humans, however, the identity of the involved compounds has remained elusive, especially since EGF and NGF concentrations are ∼100,000 times lower than those in rodent saliva. Using an in vitro model for wound closure, we examined the properties of human saliva and the fractions that were obtained from saliva by high-performance liquid chromotography (HPLC) separation. We identified histatin 1 (Hst1) and histatin 2 (Hst2) as major wound-closing factors in human saliva. In contrast, the d-enantiomer of Hst2 did not induce wound closure, indicating stereospecific activation. Furthermore, histatins were actively internalized by epithelial cells and specifically used the extracellular signal-regulated kinases 1/2 (ERK1/2) pathway, thereby enhancing epithelial migration. This study demonstrates that members of the histatin family, which up to now were implicated in the antifungal weaponry of saliva, exert a novel function that likely is relevant for oral wound healing.

Oudhoff, M. J., Bolscher, J. G. M., Nazmi, K., Kalay, H., van 't Hof, W., Nieuw Amerongen, A. V., Veerman, E. C. I.

http://www.fasebj.org/doi/pdf/10.1096/fj.08-112003
As I've argued here previously (https://news.ycombinator.com/item?id=16209310) the plunging prices of photovoltaic panels will result in plunging energy prices, starting in the early 2020s. (They're already exerting some downward pressure, but so far it's only in limited areas and for marginal capacity.) Perhaps in Tennessee these plunging prices will not result in increased demand, due to poor planning and institutional inflexibility, but in many places in the world they will.

So the statement, "TVA will sell less electricity in 10 years than it did 10 years ago," seems very dubious. It's predicated on electricity generation continuing to cost the same as it has for the last half-century or so, modulo minor improvements. But at this moment we are seeing the beginning of a dramatic disruption in those prices. So this is a pretty bad way to make that prediction.

It seems a lot more likely that the plateau in electrical energy demand in the US from 2005–2025 or so will turn out to be temporary, not a "new normal".
It's probably safe to err on the side of caution and assume that any application that stores personal data in permanent storage is a data-intensive application.
You also have to consider whether or not you accidentally restored a deleted user's information if you restore one of those backups.
In my experience, chronic lateness is a function of the person. The person who is late at 9am will be late at 6pm or when they choose the time or when it's a block from them or a city and a half away. (Note: I used to be this person when I was younger. I now leave for any meeting in my city one hour before and then hang out until the start time.)
How about, paint gun, nail gun, staple gun, there are so many products with the word gun in them.
Replacing an Else-If Sequence with a Ternary Operator
Yes, Europe is sending us their best so the sample in the US is not representative.
I think you are responding to someone talking about people who share the cultural upbringing of Europe rather than race. Unless you think race is a powerful indicator of criminality?
Arrest when you have a layover in the EU for some reason, on purpose or because of an emergency.

And a default judgement.
Did anyone else notice that FB mentioned accessibility as one of the reasons that people should opt-in to face recognition? I wonder whether this was something that the FB Accessibility team actually asked for, or whether this is just a do-good sounding excuse for a program that FB wants to (clandestinely, apparently) launch.
I am very happy that they are not supporting JS. I am absolutely tired of JS and it's "ecosystem" trying to edge their way into every facet of computing.
Lack of libraries is a valid reason for preferring another language.

But, when Go came out, there were no libraries. And it didn't get so much bad press.
> Why is simply insisting on something that is listed in the universal declaration of human rights something that should warrant a tinfoil hat?

But you're not insisting on that. You're insisting that no-one takes a picture of you, even (presumably) if you're standing in a public place.

You might want to read what the rest of the UDHR says before you try and infringe on the rights of others.
Looks like you are active on social media (Twitter, anyways) which seems at odds with your extreme privacy stance regarding pictures. Why the distinction? (not trying to attack, just curious)
I don't think I'm reaching. Read the comments below, about the fact that children learn this spine-bend posture early on, way before any sedentary lifestyle. I'm pretty sure 3-year-olds aren't using washing machines either.

I'm speaking from firsthand personal experience, and overwhelming experience seeing others go through the same cultural conditioning I described in my post.
> Oh. And many remember Dart being optional-typed (like Typescript).

So? Some could argue it's a very productive approach.
What if, instead, you were talking about those items because Facebook's algorithm manipulated you into thinking about them?
This is a bit confusing, I have a website and I log IP addresses in my web server log and I use google analytics, what do I need to do?
Based on my understanding of the Bay Area, where I've worked, my usage is definitely more frequent and in larger dosages than 99% of employed individuals, but many people consume cannabis on a semi-regular basis. Dunno about the narcotics or amphetamines, it's not something I hear about regularly.
The Trump adminstration was literally exploring changing the First Amendment:

http://theweek.com/speedreads/695695/reince-priebus-admits-t...
I'm sure they're on the lookout for that, as well. If they have enough confidence in their model, I'm sure they'd raise an eyebrow at something that only has 30% confidence, say "thanks", and then simply flag my account to not be trusted to train their models.
And people will have the FBI going through their mail because an algorithm written by someone who lived by "move fast and break things" flagged them as a commie (or whatever the equivalent is 30yr from now) over some combination of things they posted in high school.

If you spread incompetence around just right the end result is approximately the same as malice.
It's a municipal utility chartered to serve the public not profit from them. And they don't want to make risky massive capital expenditures on another discrete block of capacity.
A lot of energy is spent on things like transportation and heating though.

At some point, the rooms you occupy and the time you occupy them hits a ceiling. I'm not going to heat my room above room temperature, I'm not going to be in my room more than 24 hours in a day, even if energy efficiency made it as cheap as my current pattern of heating.

Similarly, there is a ceiling as to the amount of time I spend traveling in a certain day, I wouldn't drive to another country on a 5 hour trip on a daily basis for a better job, even if energy efficiency made it as cheap as my current travel pattern (1 hour a day).

That probably wasn't always the case, but there are indeed diminishing returns to spending money. Just look at Bill Gates' energy expenditure. It's waaaay higher than any of us in absolute terms, but relatively speaking a fraction of ours.

So I think the intuition you responded to is probably pretty solid. The other intuition I have, which is very much related, is that our gdp growth is increasingly service-oriented. i.e. it's not just that industries get more efficient, thereby seeing gdp growth and energy consumption decouple. It's also that the relative share of our gdp is possibly moving away from energy-intensive industries, which aren't really growing much at all, to low-energy intensive industries. With agriculture and manufacturing being quite energy-intensive compared to services industries like education, legal services, finance (ignoring proof of work) etc, a deindustrializing economy should also fuel a decoupling of energy consumption and gdp growth.
> I'd never use Dart otherwise

Why not? I write Dart as part of my day job and it's a very nice language. It always does what you expect, gets out of your way. All my mistakes are my own bone-headed mistakes, not due to the language. That's a great trait in a language.
3Ms graphic cards went to cryptocurrency mining farms in 2017
Not true. Optimization of chemistry is going to happen unless explicitly hindered by something else. Here, they basically crippled a protein that increases the fidelity of protein synthesis, so there's a fitness advantage to any bacteria that can increase the effectiveness of the ancestral version. It wouldn't matter if the bacteria were in a swamp or someone's intestines or a petri dish - better protein synthesis is always better.
That's monopoly in action. Given right-of-way exclusivity, there's little reason to endure the enormous costs of upgrading. Were other companies given opportunity to compete, you'd see a lot more improvements in shorter times.

...hence the explosion in wireless technologies: multiple providers can easily cover the same areas, and must compete with improving services. It's almost to the point of overtaking wired services in both data rates & cost (just get those monthly data caps up and I'll switch).
There’s a little bit at the end of the article saying Khronos is doing the same thing to put Vulkan on top of DX12.
Reminds me of one of my favorite lines in The Big Short:

"I told you we'd meet again. Unfortunately it's a place like this I would never be in... I had fashion friends."

https://www.youtube.com/watch?v=enxLiMNGpkA
> you're less inclined to talk about work stuff because neither of you will understand the nuances of the other's job.

Yes, thank you for this! I was struggling to articulate why those novel conversations happen, but this is totally the reason.
Service Workers are a subset of web workers and are heavily used.
The article only refers to electricity demand in the US. World demand is stil growing, and I think the energy system is most properly viewed as a global one.

I would be interested to know whether the embedded energy consumed by the US has been growing or shrinking. (To calculate this you would add in the energy used to make American imports.)
I'm not afraid of anything, I just want a modicum of control over who has access to my data and Facebook is one of the companies that I would not trust with anything.

Why does there have to be a scenario attached to this? They've shown time and again that they don't give a rats ass about the people whose data they collect.

The default is not 'on' when it comes to sharing your data, the default is 'off', and even then it should be grounded in need. As long as I don't see the need there is no other reason that I would need to justify my behavior.

On the other hand, there is a very large need for FB to explain its behavior but hardly anybody seems to care. So I'm happy to be the exception.
I'd actually considered implementing a "soft delete" function for my service (knowledge management SaaS), out of fear that a user would accidentally delete something important.

Now with GDPR pending, I think I won't. I'll just leave my 'no sh*t delete' function in place. If I get a request to restore any data I can say, "Sorry, the Europeans made me burn your data when you unwittingly clicked the red 'delete' button (as well as the confirmation dialog you didn't read)."
I am confused. What exactly did Microsoft buy if Nokia can come back with everything they had previously?
If you want to be purely structural, why even use an interface? You can just as easily write:

type MyType = { a: number, b: string };
Ryzen Boards Reign at Embedded World 2018
Growth doesn't seem to be a prerequisite for capitalism. Rather, it's a shortcut, a cheat, that hides or forestalls your sins and indiscretions.

Picture a MLM or Ponzi scheme- as long as growth is maintained, the problems can be swept under the rug, and you don't have to go to the trouble of running a sound business.

(I'm not calling capitalism a Ponzi scheme, it's just a good illustration)
This is something I do normally as an adult in the West, but only because for whatever reason I never got out of the habit from doing it as a child.

It was my default position playing outside in the dirt or the sandbox. I didn't like getting my clothes dirty so squatting, as opposed to sitting on my behind or knees, made sense.

These days when I'm working on anything below waist height I'm usually squatting. People always remark how child-like it looks and I remark how comfortable and easy on the knees it is.
It doesn't use JavaScript or the JS ecosystem.
That was meant to be a rhetorical question. ;) But I'm glad you see this too!
So as soon as I serve my JS from a CDN I should be marked with an insecure icon?
https://en.wikipedia.org/wiki/Stratified_squamous_epithelium

Mouths heal faster because of the type of cells in there. Licking your wounds is a good way to get them infected. Use antibiotic creme and a bandage.
Why don't you use a type alias instead of an interface for pure data?
Show HN: Story Graph 2.0: first major update incl. conversion to TypeScript
So having been through the preliminaries of GDPR, I took away a few things.

First of all, the enforcement path is as yet unclear. If they (europe) see you are doing something (like not responding to "right to be forgotten" request) it is not clear what enforcement they will attempt.

Second, there is the customer perception. If you have one European customer that buys something from you, or enters their email for you to give them some product information, and they request later to be forgotten and you don't, there is then a chance of public perception that you don't comply.

But there can be other avenues of exposure. For example, if you are dealing with a US bank that does comply with GDPR and you don't, there may be some pushback from the bank. So while EU may not come for you directly, there could be a secondary effect.

From a little conversation with European partners, I got the sense that US was taking GDPR more seriously than some EU companies.
Not to be snarky but a couple of these points could be used on article submitted on Hacker News:

* Speak to your reader (customers) - Engage them here or on other articles to build a following whne you post

* Rebrand or reposition your story (product) - If your target market isn’t ready for your product, perhaps there is an alternative market (website) that is ready for it.
Reminds me of Thundershirts - basically vests you put on small dogs or cats - to give them a bit of compression to help them feel better.
As I understand US law, when you're in public you have no expectation of privacy, and you can't do anything about having your photo taken. This is tangental to your point, but does that also mean that Facebook is legally free to ID you in photos which are taken in public? I really don't know.

(FWIW, I'm with you, it makes me crazy when family members post all their holiday photos on Facebook and tag me in them.)
Your assumptions are not borne out in practice. Others that purposefully take my picture in order to share that on social media does not include total strangers making pictures on the streets.

But if a stranger on the street wants to make a close up picture of me then it could get interesting, so far nobody has been that impolite.
Dart is indeed a cool language but there was a huge resentment when the Dart VM was about to be shipped with Chrome and create a Google only web. It's a great burden for the language, I hope it could succeed without being put under our throats.
Downvote for using amp links.
When I did my product I would have paid serious commission to someone who does the "dirty work" of selling and is actually good at it.
How Movie Darling Mary Pickford Became the Most Powerful Woman in Hollywood
Imagine you were driving a car with a stuck accelerator an no brakes. The car always moves at 100 MPH. So you can't change the car's speed, but you can change its direction. So you can drive north, at which point your east-west velocity is zero, or you can drive east, at which point your north-south velocity is zero, or you can drive in some other direction, which will give you a mix of north-south and east-west velocities. The faster you move east-west, the slower you move north-south and vice versa.

You are kind of like that car. You (and everything else) are always moving at the speed of light, but through spaceTIME, not through space. When you move through space you are not changing your speed through spacetime, you are only changing your direction. The faster you move through space, the slower you move through time, and vice versa.
Launch HN: Slite (YC W18) – Note App for Teams
Hi HN! I'm Chris, founder of Slite (https://slite.com). We’re building a tool for modern teams to write down and retrieve things that matter.

I've launched two companies in the past and basically ran them on note-taking apps. The first was a hiring SaaS and the second an on-demand fashion-delivery service, and while the two were pretty different, I needed to write down a lot of stuff: interview notes, mentoring, email and article drafts, notes on customers and so on.

I had this habit because notes are versatile, incredibly user-friendly, and immediate. They made up my personal knowledge base but the biggest frustration I had was sharing those with teammates. So I decided to build a note app that would work with teams from day 1.

This is in line with the current problems in team collaboration. A lot of people were thrilled to dump email to get on Slack, but recent conversation has shifted towards Slack killing team productivity and leading to loss of information. This topic even trended on HN a week ago: https://news.ycombinator.com/item?id=16355454.

We’re building an asynchronous writing tool for teams to organize their work with one simple yet crucial goal in mind: make sure teams stop losing valuable information and find it more quickly. We want to remove the back and forth you have on Slack, via email or even offline to find information.

We use the same channels pattern as Slack, mainly because this avoids the folders structure where content is hard to find, organize and where permissions are a nightmare. But using Slite allows you to separate use cases: channel chat a la IRC or Slack to communicate instantly, Slite to write and retrieve information.

Another major product focus is search: existing tools such as Google Docs or Dropbox Paper make it hard to organize and navigate through content (not to mention Slack where everything get lost between cat gifs). We put huge efforts on making it seamless in Slite.

With these basic differences we've already convinced hundreds of teams and thousands of active users to switch their content over from Google Docs, Dropbox Paper or other tools. We’re now entering a new phase where we’re focusing on integrations, allowing teams to push and access their information from anywhere in their workflows.

It’s an exciting time and we’d love for you to check it out and give us your feedback. And we're eager to hear your ideas in this space. Please share your thoughts in the comments!
I'm good at the emotional intelligence thing. Some things I have done:

I have taken college classes pertinent to the topic, like Intro to Psych, Social Psychology and Negotiation and Conflict Management.

I have attended conferences with pertinent info. I also attended parts of the conference that were more social and less technical in nature in terms of the kind of info covered.

I have read a lot about how the mind works and how different people experience life differently because of various issues.

I constantly wonder what the first person perspective is. When we take a third person perspective, we often feel people are just behaving badly. But people generally have reasons why they do the things they do. Trying to see it from their perspective is powerful for problem solving.

If you do nothing else, do that last thing. Always wonder how people are experiencing what they experience and their motives for making the choices they make. Context matters and most people seem to forget that.
And people say they hate cold callers! Why could this be??
A good chunk of europe isn't common law, how much does case law apply in these cases? In those countries the statute matters a lot more.
Good point, I was wrong. The road tax policy should be updated to take NOx levels in to account. The recommendation remains :)
The point is that a Dart library can write a parser for XML, but if XML was the only supported format, it's hard to go in the other direction. Also if you read example Flutter code, you may notice that their UI spec DSL-like is 'declarative'.

In terms of a 'change' as you point out, change is a comparison between two points, and when you compare XML to this declarative paradigm, the main difference isn't along the declarative-or-not axis (because they are similar in that regard), but things like programmability (often with 'templates' in XML) or parseability, in which case in-language DSL-likes work really well (you can write, for example, a lambda returning a UI fragment that closes over some parameters, or you can `.map(...)` a UI fragment over a `List`, ...). The change you may be pointing at is against maybe original GTK-like or Android-Java-like imperative constructs, but this discussion is about a Flutter-XML comparison.

Of course, in the Flutter case, the DSL-like is actually just function calls and doesn't involve macros or a separate code generation step.
A Statistical Search for Genomic Truths
I think demand is far greater than what is currently visible, but the price is still way to high.

I'd move to electric heat in a heartbeat, but it's 2-3 times more expensive than coal, natural gas or oil (those are the most popular choices in Poland). If the price was 1/3rd of current, tens of percent of all citizens would move to a different heat source, using a lot more energy than they do now.

So it's just a price problem. Make it cheaper (maybe renewables will) and the demand will come quickly.
Supposed inventor of Bitcoin sued for $10B
I think it is changing.

My personal opinion has definitely shifted, maybe partly because I'm tired of inferior Android experiences of the same app, but also because the looks of Android and iOS seem to be converging anyway.

While maybe they couldn't before, many apps seemingly can now get away with one UX for both platforms - that is a strong simplifier and gives a potential branding advantage.

It may be a good idea to still implement some "platform sensitive" widgets (some behaviors are still slightly different), but the demand for them seems to have drastically gone down.
I don't read that as "no one can take my photo", though. Certainly that language should protect me from people invading my private space to take photos of me, but if I'm out and about in public, I should have no expectation that no photos will be taken of me, and I would feel very wrong asking someone to delete a photo of me in a public place. I would consider that to be infringing on their rights.

I get that photos of people can be a lot more harmful than a casual photographer might assume, but I would never accede to a request from a random stranger to delete a photograph that they just happened to be in. If someone requested that I not take a photo of them, I personally would comply out of a sense of politeness, but I don't believe anyone has a legal or moral obligation to comply when in public.

(But yes, I know, this is just my opinion and preference, just like yours is yours.)