skysight-inc/HackerNews huggingface dataset:
I found this announcement of a follow-up study [1], which

> will see 140 people with Type 2 diabetes spend between eight and 20 weeks consuming just 800 calories per day, mainly in the form of nutritionally-complete formula shakes.

The phrase "nutritionally-complete" indicates a meal replacement; probably not Slimfast or Ensure, neither of which is suitable for 100% meal replacement, but something like Huel or Soylent, which are. However, being a medical operation, I would bet it will be some hospital-approved TPN [2] such as Jevity [3].

[1] https://www.diabetes.org.uk/About_us/News_Landing_Page/Low-c...

[2] https://en.wikipedia.org/wiki/Parenteral_nutrition

[3] https://nutrition.abbott/uk/product/jevity
OK, changed. Thanks!
there isn't the information required for it to sound like indentured servitude.
Healthcare costs in the US shows no signs of dropping long-term.

There's also no radical developments which change or automate prescribed or preventative care, with some illnesses resulting in very expensive hospital stays.

Healthcare salaries are also not expected to drop long-term, and will probably increase.

Cancer rates also go up as you age, resulting in chemotherapy and other expensive forms of healthcare and tests.

Insurance also fights to avoid paying out, and they're probably not keen to stop doing this, either. You generally become more expensive to insure as you age.

Healthcare law is also subject to intense debates within the US, and every change of administration brings risk of those laws changing.

Costs of developing drugs and procedures is also probably not going to go down either, resulting in pharma companies having to charge more per pill to recoup their costs (even if you ignore price gouging from Wall Street investors and free handouts to poor people).

And in the background, you have chronic illness costs (diabetes) and insurance premiums which always add up the longer you live. As well as environmental regulation and disasters which may expose you to harmful stuff.
I keep all my external drives ExFAT so I can use them easily everywhere.
I really don’t care about amp for email. But I’m very worried about amp for the web because it means we give up control of our content and features and will need to live by googles rules.
What use is calling it out when you "don't care what side you are on"?

You are ready to assign equal blame, when there are unequal incentives.
The Soviet Tetris Triple-Cross
8 Lessons from Reviewing 20 Years of Technology Hype Cycles
Large-scale GWAS identifies multiple loci for hand grip strength
But the title of the post uses the word preventive.
Something is wrong with his numbers.

"Johnson boasts that his electrolyzer can produce hydrogen at about three or four times the rate of electrolyzers with similar footprints, using about a third the electrical current. That represents a stepwise drop in costs."

Three or four times? Current efficiencies are 65-70% for larger plants.[1]
There's a theoretical maximum here; it takes a known amount of energy to break down water into oxygen and hydrogen. This isn't magic or perpetual motion. Electrolysis is energetically uphill. You can get most of the energy back recombining oxygen and hydrogen in a fuel cell or by combustion.

The "with similar footprints" is very suspicious. His demo unit is small. Little electrolyzers are known to be inefficient. Industrial units are bigger and more efficient.

As an emissions control measure, it might work out.

[1] https://en.wikipedia.org/wiki/Electrolysis_of_water#Industri...
Columbia University is doing a study on it: https://clinicaltrials.gov/ct2/show/NCT03336398
If you use a credit card - you instead instruct your credit card company to initiate a transaction with them - and, if you aren't happy, you file a chargeback and then it's on the vendor to prove that they fulfilled their end of the deal.

I've filed about 5 or 6 chargebacks, and, with the exception of a gym membership, (which, admittedly, did have a contract from me stating I would send them a request via registered mail to quit) I've always been successful.
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> * Keep that schema file updated by hand every time something like Sudan breaking in two happens (no).

There is a lot of use for libraries dealing with time and dates. When you want to cover all cases, at some point you get to the situation when you have to allow variable number of seconds in a minute - not always 60, but sometimes 59 or 61, or may be even different numbers. And you don't know in advance - for arbitrary long future - which minutes will have which number of seconds.

So, for your timekeeping system to maintain precision, you have to allow external updates for when a minute will be considered non-60 seconds.

And those cases could happen more often than changing a list of valid country codes.

What would you do with time then?
Esketamine[0] works as a NMDA antagonist. Most nootropic drugs, and anti-AD drugs have some interaction with AMPA, NMDA, and glutamate.

I have a hunch that most mental illnesses have to do with a dysfunctional glutaminergic system, with some misbehaving AMPA/NMDA signaling thrown in there for good measure.

[0] https://en.m.wikipedia.org/wiki/Esketamine
Sorry to hear that...
>It removes odor that soap alone doesn't

Assuming it removes onion and garlic odors, how does it follow that it would remove body odor?
Is it more readable? I'm even less familiar with D than APL, and that D code only looks more readable to me right now because it's mostly comments.

Wouldn't adding 8 lines of comments help newcomers to APL, too? This seems like a rather unfair contest.

Familiarity counts for a lot. 25 years ago when my primary language was 6502 assembly, I would have said 20 pages of assembly code look more readable than either of these.

In the long run, though, in every field I've worked in, being able to turn 20 lines of code into 20 characters has turned out to be a huge benefit. Once you familiarize yourself with the vocabulary, you can operate at a higher level. Nobody fears concise names and symbols when it's in a context they understand. I think even the most APL-phobic would admit that "a←b+c" is more readable than "assign(a,sum(b,c))".
Agreed. I'm a big fan of free markets. But the modern tendency toward a sort of fundamentalist capitalism is repulsive.

A good way to make a profit is to make something people need at a price they can afford while paying your employees well. But you can't work that backwards. Not everybody making a profit is creating value or contributing to society. If you don't have a conscience, or even if you're just not thinking very hard, it's easy to privatize a gain and socialize the losses. It's our job as citizens to make sure that is minimized.
Really interesting. As well he seems to re-derive and implementation of Forth.

In episode 6, Right under the diagran for Crema di Marscapone he has a formula.

Does anyone that uses Forth know if it has that circle-plus operator? It seems to really lend to conciseness - and I hadn't remembered anything like it last time I looked at Forth.

https://graphicallinearalgebra.net/2015/05/06/crema-di-masca...
While visiting LA I went to a farmers market. I paid $11 for a single cup of coffee that I was promised would blow my socks off. Bourbon barrel roasted something.

It was _good_ and the novelty was nice, but I probably wouldn't choose to do it again. Instead I just do my own pourovers at home for ~$0.30 each and add my own flavors at brew time (e.g. ground cinnamon sticks.)

I can't say much though, I grudgingly support my wife's Starbucks habit at $5/drink and just a few years ago I found that just as ridiculous.
Web browsing for badasses: Hacks and tricks for people who are okay at computers
It is just a subset of HTML (as is amp). Most email providers that accept HTML formats already only accept a subset of HTML. This is just a different, more formally defined, subset.
I still wouldn't pay $18 but I'm sure some would.

That said the best coffee near me is in the little market and it's both cheaper and vastly better than star bucks, I go there after Chess Club on a Saturday and review the games I just played, it's so good I would pay £5 (~$7.5) for that one cup a week because it's an experience not the caffeine, the rest of the time it's LIDL's Columbian instant (which is a damn fine instant).
See-Through Hair and Awkward Sexual Problems: The Woolly Mammoth’s Bitter End
That diagram is pretty cool :D

It explains the terms in a visual way with 5 ascii lines (probably a little exaggerating and not 100% correct, but easy to grasp).
> Go 1.10 is the last release that will run on Windows XP or Windows Vista. Go 1.11 will require Windows 7 or later.

The OS X >= 10.10 and Windows >= 7 requirements of Go 1.11 is good reason to maintain compatibility/support for 1.10 for some time. I don't have a sense for the impact to *bad systems in use.
They are trade secret, so can't describe them here, but currently using algorithms created by my skip level manager [1] to make actual physical money.

[1]: https://www.cranecurrency.com/rnd-banknote-security-thread-f...
> Last time I checked, XML was uncertain which validation should I use. DTD, Schema, other solutions

DTD was considered obsolete more than a decade ago.

Nobody uses anything but XSD nowadays.
It you control the redemption rate then you can just force redemptions below some level that keeps you profitable.

Airlines do this already, frequent flyer-eligible tickets are a small portion of the overall tickets available, blackout dates, etc...
“I can't say much though, I grudgingly support my wife's Starbucks habit at $5/drink and just a few years ago I found that just as ridiculous.”

Well, in this case what you’re paying for is not the coffee per se.
They are both under heavy development. MySQL is still increasing revenue for Oracle, and MariaDB raised another $27M towards the end of 2017. They're both here to stay. The less clear question in my mind is how long they will remain compatible.
Weird, I dont see any scripts other than disqus and google analytics.
For example they had to decouple their browser from the OS. In Europe they were forced to offer alternative browsers.

I also wonder if their investment in Apple was at least in part motivated by them being investigated. There may be no Apple today without that.
The gnu utilities are fairly well documented in info pages
The Fuzzy Math of Funding Iraq's Reconstruction
In their native habitat or at a standardized temperature?

I'm Scandinavian, and I'm comfy and dry when I can wake up seeing my own breath. After moving to California, though, I'm pretty sure I'm single handedly ending the drought.
I'm not sure legalizing IP theft makes a country freer, because the person who owns stolen IP is deprived of the opportunity to profit from his own ideas.

This applies to other types of theft too. Would you say that a country where people can legally steal food away from each other is freer than a country where this is not the case?
are perhaps specifically not piracy

Well you'd still get to do all the pirate stuff, buckling your swash and splicing the mainbrace and all that. And there would be pieces of eight aplenty. You just wouldn't get hanged afterwards. Win-win situation!
It pretty much comes down to weather.

Importing water is easier than importing sun and heat.
I agree. It just seems that police is converting into a wannabe military force because it's cool to wear camouflage, helmets and big guns.
The hourly employees are paid significantly more than Walmart/Best Buy/Target employees. In my home state, they start at $14-$15. About 2x Walmart.They also have programs for veterans to make even more.

They will also pay for community college degrees for those employees -- and it doesn't have to be related to their job nor do they have to stay at Amazon. I believe only in certain fields though, like STEM degrees.
This comes up a lot here, but in theory a government is supposed to make hard decisions to prevent that tragedy. On its own simply saying “tragedy of the commons” is like a trauma surgeon saying, “sucking chest wound,” without stepping in to fix it.
I'm class of '05 and remember it being something you could get.
Their competition has data too. Maybe not as much, but plenty. Walmart sells more than they do, I bet they have more data...
> You can likely get an antidepressant effect out of Esketamine in the same way that you can get an antidepressant effect out of psychdelics like LSD-25 & Psilocin.

LSD-25 and Psilocin simply amplify your emotional state at a given time, because they act on 5HT receptors. That’s not what an anti-depressant does. In fact, anti-depressants help one regulate emotions correctly. In that sense, Esketamine is truly novel for being a rapid anti-depressant, because it acts as a NMDA antagonist.
Human Rights Advocacy in the Dawning Age of AI
Making native UI in Java on Android is such huge PITA. While I've never used js/html app that was not bad, it's still 10x better.
The best, hands down on YouTube.
Methanol is commonly sold as "octane booster". It's definitely around.
No radical developments? Near all medical expense is at present due to age-related disease. When the distinct and understood causes of aging can be treated as medical conditions, which at present they are not, then that expense will be reduced. Rejuvenation biotechnology to repair the causes of aging is a going concern. The first legitimate, actual, real rejuvenation therapies that turn back one of the root causes of aging are in early human trials and preclinical development. They are largely low-cost. Efforts to slow aging by slowing those causes are a larger going concern. Those approaches are similarly largely low-cost. It is clearly the case that a tipping point has been reached in support for efforts to treat aging in order to, eventually, indefinitely postpone the mortality, cost, and suffering of old age.

Just ahead, in the next few years, there is the start of a massive shift in medicine for the old, medicine associated with the greatest costs. It is beginning now.
Yep, recently I've been buying Chess sets and Amazon sucks absolute balls at that, I can't filter the over priced shite from the decent stuff and figuring out who is supplying what is hard.

In the end I just bought from a uk chess specific supplier and all my questions where answered on the page.

Now that's a niche I acknowledge that but still with all their data and product ranges a small online retailer beat them.
I'm skeptical of your claim, may be on the books but enforced?

Even taking you at face value this is a clear case of whataboutism. Finally errors of almost 30 years ago give these assholes a pass how?
Oh, if you're talking about anything on the front end more rich than simple classic forms and full page reloads, I agree. It just wasn't clear what you meant by "non-trivial".
Call me ignorant, but isn't Vue.js effectively what backbone and ember were trying to do all those years back? Feels like React sort of changed the paradigm for the better. ::shrug::
Plymouth man completes 20,000-mile pub adventure
No, but the links are by default not clickable.

https://news.ycombinator.com/newsfaq.html
It is pretty unique in the US. Most other vendors will take 5-7 days to get to me in the north east (probably because a lot of imported goods end up warehoused on the west coast).

I don't think too many other online vendors in the US have their own delivery vans/trucks.
"Doggie" pronunciation just makes more sense.
Ask HN: Why does it take Apple so long to unlock an iPhone?
Right. I don't mean to dismiss the "value" of the C64. But it was more like Commodore accidentally released something good, and then sold at or below cost to run their lower-end competitors out of business. Commodore 64 obviously had a enthusiastic user base, but the users recognized the "value" more than Commodore did. Commodore's business model was selling a lot of cheap computers to people who wouldn't actually use them, so the Plus/4 was just as good as far as Commodore was concerned. And yes the Commodore 64 was seen as cheap -- you could walk into Target etc and get a computer for $250!

On the techie side of the internet now, a lot of people have a positive perception of Commodore because they got one when they were 13 or whatever and got into it. We don't hear from all the people who couldn't find a use for it or never bought the disk drive (another $250) and ended-up shoving it into their closet. At the time, Commodore was not considered a reliable well-run company. There's a reason the schools bought Apples.
I think the answers to your questions are unfortunately not scientific but business related

Fast track designation must be requested by the company developing the drug. J&j is developing esketamine; I don't know of any companies developing arketamine

I think a big reason j&j decided to develop esketamine vs ketamine is because ketamine is an old approved generic drug (i.e. Cheap). they chose it over arketamine probably for all the pharmacologic and therapeutic reasons cited in the second to last paper you link to. Last December they released phase 2 data that looked pretty good though there were dissociate side effects

The new data on arketamine are interesting but I view them with a grain of salt. There's only so much you can conclude about depression biology and structure activity relationship from animal models. Plus the mechanism of action of ketamine is so complex and poorly understood that by trying to be too precise with our receptor targeting we risk losing desired traits. We don't really know that AMPA is a better target than NMDAR; and we don't know the right ratio, and we don't know whether there are other important receptors beyond these
But what about the oceans?
...until said water runs out, then you’re hot, sunny, and dry.
On the other hand Amazon is notorious for tax shenannigans in Europe and that's something that a small company just can't do effectively, so Amazon can leverage it's size and reach to compete on a field the small retailers can't get on to play on.

That isn't an Amazon problem though, that's a "the smart guys are on the wrong side of the table" problem, big business pays better than government.
sorry I should have said it is a fair reason to dismiss.
Exfat is also painful to use in OpenBSD. There is something called exfatfuse but it is quite buggy.

The only way I could make USB drives that were usable on other machines was to use fat32 with mkfs.msdos.

OTOH NTFS read support is excellent on both FreeBSD and OpenBSD. But overall I admit that it is painful if you need to work with USB drives.
> It still seems illegal under UK law

CMA doesn't apply: https://www.legislation.gov.uk/ukpga/1990/18/section/10

The powers of GCHQ are basically unconstrained by the law: "[GCHQ shall] monitor or interfere with electromagnetic, acoustic and other emissions and any equipment producing such emissions and to obtain and provide information derived from or related to such emissions or equipment and from encrypted material [...] in the interests of national security, [...] in the interests of the economic well-being of the United Kingdom [... or] in support of the prevention or detection of serious crime." per http://www.legislation.gov.uk/ukpga/1994/13/crossheading/gch...
Thanks. I doubt this could be a security issue. Typical usage like so

var name = one(users, '[_.id==?].name', 123)

uses parameterized queries, same idea as with SQL to eliminate injections.
Ok, we changed "truly native apps" to "native UIs" in the title above.
It would be interesting to see a performance comparison between libdill and goroutine for concurrent network requests.
Given what I’ve learned about fraud in the wine world, the nature of individual taste perception, and the inflated value of wine... I’m sure it is entirely similar.

Useful references: https://en.m.wikipedia.org/wiki/Wine_fraud
I do not think IEEE-754 is mandatory for any work load, it is just that using fixedpoint arithmetic, especially if mapped onto of a number of common integer types tends to be more complex to implement then simply using float.

With fixed point you have to be much more aware about e.g. the min-max-range of values and the precision needed, potentially changing them between different computation steps.

If you have any complex math algorithm you should also look into this aspects with float for error calculation etc. So maybe using fixed-point would not be so bad there, but for a lot of "just get it done" tasks people want to just have a float and not bother about it.

If you have a way to quickly translate math specific programs using floats + little amounts of meta data into math specific programs using fixed-point arithmetic including error analysis/correction* you probably would get ride of >90% of float requirements, through you would "still" have all that legacy software ;=)

[*] If I remember correctly someone did that for Neural Networks using tensorflow, but I don't remember the details
good luck going through all those places with different legislations on self driving cars without getting arrested a billion times, even twenty years from now, I'm sure
Not sure if it was intentional or not but I enjoyed the irony of putting two Amazon links to the book "The Box" directly in the article.
I think it's more like the surgeon is being held back by people saying "No, don't step in because you'll make it worse! The human body can heal itself." And you, the surgeon, can do nothing but mutter "a punctured lung ain't gonna heal itself."
HomePod Rings and Apple Problems: Explained
I think the much better question is why are only 2 U.S. states allowed to grow coffee?
Is there a definition of "perfect health" in the QALY framework? One year of life in twenty year old body is probably better than in one that is sixty, for example.

I ask because at some point we could be asked to consider treatments that could take the "perfect health" score above 1.0. I'd argue that people who do potentially dangerous things like taking steroids already do something like this, valuing a "1.1" year of health now over a potential number of "0.5" years later.
It doesn’t compile it to JVM, it runs a JS engine, and then passes some calls into the native side over an asynchronous bridge, and the native code then builds native views at runtime. It’s a middle ground, and it’s super useful in some cases, and super dumb in others. It’s not a silver bullet, it doesn’t solve all the problems, but it has some good use cases.
This is the 100th thing claiming to be native when it's not.
Like putting a "native" in it's name does not make it so.
Traces of Old Egyptian in Eurasian languages?
Why adding value to other people always comes first
Overpass?
I had never heard of the commodore KERNAL before and I had no problem following it. In addition, the term kernel has many uses in computing besides OS kernel.
By far the best description of what’s happening at Apple.
> focusing on longer-term growth and success

Traditionally, the market has not supported this. Government parties need funding now not some time in future. That said I do not know about the US. I think if you run a big business, you need to keep everyone happy which includes investors and governments for that you need money today. The easiest way always has been to extract more money from customers.
AndStatus: libre Mastodon/GNU Social/Pump.io social networking app
That depends though on a bunch of factors including base price of electricity, renewable potential and how easily hydrogen can be shipped.

There are a few developed countries I can think of that have vast renewable capacity but the distances between the optimum location for renewables make it impractical at present.

Also modern nuclear plants are an option if you want to produce vast amounts of electricity with a smaller carbon footprint than coal/gas.
A good surgeon should step in and accept the consequences, while saving a life; that is ultimately what they signed up for. No one said it would be easy or make you happy to do good, right?

Still, I’m not ignoring your point, which is solid.