skysight-inc/HackerNews huggingface dataset:
There are existing immunotherapies that already target PD-1 receptors, which is what the article’s treatment of T cells is doing ex vivo.

Pembrolizumab, for example, is an FDA approved first line therapy for all cancers expressing high microsatellite instability or mismatch repair which is a highly conserved attribute among people who smoke and drink, one of the main reasons for why China has such an abnormal amount of cancer in their population in addition to additional extraneous factors like rampant pollution, due to their extreme carcinogenic effects.

This article seems to imply that the risk aversion taken by the FDA is resulting in lives not being saved, but is incorrect in it’s assertions. Especially since the utilization of CRISPR is still at a stage of, what is in my opinion, the creation of an unnacceptable mutational burden, immunotherapies like pembrolizumab which work to inhibit receptors through the usage of monoclonal antibodies are the best forms of treatment. In no way do I doubt the potential of gene editing and the good it can do, however, when I say this. The point is though, is that when you rush things too quickly, it inevitably ends up hurting the patient.
moms are loved almost 3 times more.
I'm Thomas.

http://warinheaven.net
If happiness is relative and based on perception, could you make the argument that making everybody equally poor would be just as beneficial as contributing to everyone's success, rather everyone willing to work for it? If you continue to move the "goalposts of happiness" you could end up in a situation where there is the potential to do right by 98% of people, but you decide against it so that the 2% don't feel bad.
Note that gun regulations are actually rather stricter in Norway than in the US. For example, automatic weapons and many high-powered guns are completely banned.

That said, I do believe that the relative safety of Norway is due to other, cultural factors. (I'm Norwegian.)
I suppose the question is how much faith you have in oversight boards to actually produce ethical outcomes.

My worry wouldn't be "they'll cut down on competition to ensure ethical behavior", it would be "they'll block competition and protect their member instead of ensuring ethics."

I think the top-level essay here is extremely cogent: oversight is almost always limited to ensuring competence. In medicine, that gets us 'ethics' when ethics means "providing good care and avoiding bad care". (It hasn't gotten us ethics when the question is anything complicated, like defining mental illness.) Competence in data science and software is largely orthogonal to ethics, so I expect an oversight board would achieve very little in that regard.
Sorry for the late reply. I am aware of the keyboard issue. It's a bug in iOS 11 and its already reported to apple (bug : 34229664). you can access the share screen by clicking on the 3 dots at the bottom.

The new update (v 1.0.2) also added Ad blocker.
Your second point, as specifically phrased, is probably factually false.

SCotUS ruled in Feist Publications Inc., v. Rural Telephone Service Co. [0] that, "Many compilations consist of nothing but raw data — i.e. wholly factual information not accompanied by any original expression. On what basis may one claim a copyright upon such work? Common sense tells us that 100 uncopyrightable facts do not magically change their status when gathered together in one place. … The key to resolving the tension lies in understanding why facts are not copyrightable: The sine qua non of copyright is originality."

This is the source of what I've heard called the "phone book doctrine" of copyright (though I'm not finding any hits on that phrase in a cursory search, so it may not be a widely used phrasing).

Publications "which contain nothing more than factual scores / play statistics" per se contain no originality, and are consequently not copyrightable.

(IANAL)

[0] https://en.wikipedia.org/wiki/Feist_Publications,_Inc.,_v._R....
Almost like health insurance is some kind of Giffen good, or like some other economic sink, gobbling up alternative destinations for resources.

Here's some random critical analysis on the topic: https://randomcriticalanalysis.wordpress.com/2016/09/25/high...
> [...] instead force everyone to accept long lines.

You don't need to accept long lines as gofmt respects your own line wrapping. It's easy to write code that never exceeds the 80 character limit. The main annoyance in go is it's use of tabs, so you have to change tabs in everything to a reasonable amount of space.
I've slowly been working on a native version for Windows 10, source available here: https://github.com/signal-csharp/Signal-Windows
> However, I got a lot of feedback from V1 along the lines of "simply blocking 320M passwords is a usability nightmare". Blocking half a billion, even more so.

What, why?
"a federal judge ruled that a case against supercomputer manufacturer Cray could be kept in East Texas because the company employed a single work-from-home employee in the district."

That seems crazy. Poor Cray guy....company is pulled into his backyard in a bad way because he worked from home.
dep will ignore the library's vendor directory entirely. You don't need to do any of that work yourself. dep will do it for you.
https://github.com/golang/dep
Where the money goes. Seriously. We routinely see Angel and Series A rounds raised by Professors with little business experience that are 5-10X the amount an early stage AI company would get.

I'd really be interested in seeing the blueprint for how to bootstrap a successful synthbio startup starting with a single, garage-sized DNA foundry.
I hate people abusing ccTLDs for "cute" domain names. It breaks everything about how they are supposed to be assigned/used.

The biggest assclownery was .ly, IMO -- an islamofascist rogue state (then; now just a generic failed state) being used for various domains.
You might want to research the legal cases regarding copyrighting recipes.
How to find innovative ideas?
"my wife was also poor but she is the best person I've ever met"

You still make it sound like you see it as some black mark against someone. I doubt you meant to come off that way, but you really did.

Imagine if I said:
"Xstartup is (gay,black,jew), but is a really great person"

Sounds bad huh?
Yeah the snow plow issue is a problem. I've had google send me horrible ways to avoid the highway. I get what they're thinking with the math generally, but it was terrible advice.

Google wasn't wrong that those roads were clear... because nobody wants to take those roads because they're not plowed and dangerous in bad weather.
There is a great Freakonomics episode on exactly that.

tl;dr was that people don't like buying stuff via auctions.

http://freakonomics.com/podcast/live-event-ticket-market-scr...
All things being equal, you're always better off taking care of yourself. But you're better off investing your energy in proven strategies and not whatever nonsense you see on the internet.
I would suggest you actually try and base things on facts not gut feelings. Because that's not what actually happens at a factory. I have no objection to saying the 50 people laid off will likely be worse off for the next few years. But, automation tends to reduce the need for visual inspections a machine that did it correct on a random sample of 5 / 1000 is likely to do a good job on the other 995. Someone might glance at the rest but that's ~1% of the effort of making something and likely 1 job out of the 100.

At really high levels of automation say 10,000 people replaced by 50 that might be a different story, but I am taking about gradual shits not massive and very rare disruptions.

The question of what happens to everyone else is interesting, but the standard of living has generally increased slightly with increased efficiency. Healthcare may be expensive today, but it was not available 200 years ago. Look back say 20 years and you can get basically all the top drugs from 1997 for cheap today.

Even land is not that bad, you can get an acre of farm land for in some parts of the US for under 1,000$, look at remittances from day labor's and the early American dream is within reach of just about anyone. The real change is people's expectations not their absolute earnings.

PS: Now, what separates factory jobs from most work is the power of Unions and the ability to strike effectively. Unions tend to increase worker pay irrespective of the free market, but that's a different story.
> In reality, this ill-conditioned model can arise for two reasons

> + The equations represent a physical system that is ill-conditioned

> + The physical system is not poorly conditioned, but the model is

In my experience, there are other ways this kind of problem can come up where it would have nothing to do with the model or the system being ill-conditioned. I'll give one example below, but I expect there are more I'm not thinking of.

One that I recall encountering is, say you have a model, and you compute the time 't' at which some event occurs (say, the time at which a condition x < h is violated) in some part of your model. Once you find this 't', you plug it back into your full model and evaluate the model at that time. Now you try to compute the time of the next event and repeat. But there's no guarantee that x = h (or even x >= h) at this time 't' here, even though that's the condition you solved for... and if x < h again, you can get stuck here re-evaluating the same event forever. And notice this had nothing to do with the system being ill-conditioned; it was purely due to FP round-off making x just a tiny bit smaller than h.

Now, there are two ways to fix this example. The usual hack (once you notice the implicit x = h assumption, which only obvious because I just told it to you, not when you're actually coding) is to just set a tolerance parameter for |x - h| being small... but introducing tolerances doesn't always solve the problem and in addition can introduce more messes of its own, since tolerances become quite difficult to reason about and deal with in the presence of feedback (they can cancel or compound themselves, for example) and you don't want to have to keep figuring out reasonable tolerances for every condition. On the other hand, there's another (nicer) solution: simply force x = h here, because that's literally the condition you solved for. The trouble is, this is a very unnatural approach, and hence very, very far from obvious when you're coding it for the first time. You have to introduce a mechanism for forcing the state of one part of your model externally, while the rest is computed internally. And you have to explicitly invoke this mechanism. It's something that makes sense after the fact, but it's very difficult to foresee because it makes no sense when you're thinking about the problem purely mathematically (i.e. in \mathbb{R}), and yet it can bite you just when you think your code that switches to finite-precision is fine (as it has bitten me).

My main point is, I wouldn't assume you can predict when these sorts of problems come up. They're not always due to poor conditioning or due to poor modeling, or poor coding for that matter. They can be products of reasonable, competent work and still crop up when you really don't anticipate them, no matter how "nicely-behaved" the inputs to your solver are.
Yes, that's been important too. But it's complicated. I gather that women are in greater demand in sectors that have benefited from globalization. Whereas globalization has cut labor demand in traditionally male blue-collar sectors. Except for trucking and construction, anyway.
Or people who love their moms are 3 times more likely to choose a bad password.
With interest rates being so low, they don’t have that either. What are they going to do? Lower it below zero? Just wondering how high they can get it before the next recession.
There were lots of people in Cruise’s seed round.

Justin founded Justin.tv and Exec. Justin.tv became Socialcam and Twitch.
Bad food habits, food choices, culture, and very low activity levels have far more significance to obesity than genetics. This is obvious if you just look at historical obesity rates, it was virtually non-existent a few decades ago.

But yes, the obese consume massive medical resources as any doctor or clinician will tell you. At some point you have to acknowledge this and find a way to adjust for that massive cost increase. Allow insurers to set premiums based on BMI, tax BMI, or have a tax credit for healthy BMI, tax junk food, all of the above, etc. Get creative, but you have to find a way to pay for the cost of being fat. Otherwise, obesity and the myriad related illnesses is going to bankrupt the entire US health system.
$500 a month? Daaaamn I'm in the wrong business.

Would anyone like to rent a private office in walking distance of beautiful Hampton Beach, NH? (Price negotiable.)
See Part 5: https://research.swtch.com/vgo-repro
Because normal humans will only be able to generate so many passwords on their own before they give up.

He also later makes the example of understanding the frequency matters — abc123 is mathematically equivalently bad to mno678, except one is far more likely than the other.
I stumbled across PKD in a Borders; I bought a collection of his short stories with "The Short Happy Life Of The Brown Oxford" on the cover. I had never seen this before, so thank you for that. These two weirdos were practically made for each other.
True. And those have all worked synergistically with globalization.
Just moved my startup(www.getpei.co) from Los Angeles to Austin for an accelerator and can attest that software is sprawling! There are tons of great meetups supported by a ton of great innovative companies and with amazing events like SXSW (which will be our first) they environment is growing for engineers.

The reason I see this happening is because I believe with the roots of live music in Austin, there is a lot of creativity growing around here. When you mix it with effective development and adventurous culture, there is a great mixture of support systems to really build a software-based community.

Weirdly enough, my company is actually looking for a CMO now in the area, and we are finding it difficult to fill the position at an early stage company. So shameless plug, if you are in the area ( which I am finding a lot of Austin is HN), please feel free to reach out!
Automation and the Use of Multiple Accounts
Unclosable pop up.
How about the advancement in steal or gasoline. Batteries are old tech. CPU advancement is very similar to increases in engine horsepower over the first 80 years which steadily doubled up to rockets and then almost completely stalled out.

Saying it's only they are only 10+x as good in the last 25 years overall is a silly standard. Recharge increase * weight decrease * cost decrease. Remember each of them are independently large improvements.

If you see the same increases happen again electric cars in 25 years would have 1,000+ mile range and charge in ~30 seconds.
$400K income in Silicon Valley is still middle-class
Boring Company tunnels free for Teslas? A prediction
Same is true for old laptops if you happen to keep them. Kind of a fun nostalgic experience to look through.
Intel releases new security patch for Spectre and Meltdown
Is facilitating committing a crime somewhere else better?
> > it's a viable packaging system that isn't NP-hard. Is there any precedent for that?

> Yes, Rust's Cargo: https://github.com/rust-lang/cargo/blob/master/src/cargo/cor.... For comparison, on my low-end VPS Cargo takes less than a quarter second to select the versions of the 289 transitive dependencies used by Servo

That's kinda an answer to a different question. The question you replied to was asking about other non-NP-hard systems and you replied with how much time your system took.
Note this relevant comment from the author of the article:

'My original title was: "Aging: where physics meets biology". Nautilus changed the title to the above more provocative version, which seemed to have worked - judging from the number of responses!'

Comment URL: http://nautil.us/issue/36/aging/physics-makes-aging-inevitab...
...this is a joke, right?
The registrar is merely the path to edit registry records; most of the ICANN agreements and registry-registrar agreements are structured to minimize exposure of registrants to bad/failed/incompetent/evil registrars.

There are some registries which don't have registrars, and in that case "suspend the registrant's domain name until paid" would be a reasonable expectation, but it's definitely the expectation of most registrants that their registrar isn't providing availability-critical service, merely facilitating updates. (Unless the registrar is also providing DNS hosting, which is generally a bad idea IMO.)
Detroit might be okay if you like long commutes, no transit, and (typically) conservative workplaces. Pay seems like its increasing a bit, if stack overflow jobs is any indicator.

It would be an awesome place for a startup with all the cheap property and rent.

People here are nicer than anywhere else I’ve ever lived

I miss biking and walking to work. And while thats possible here, it’s not easy to find.

But Detroit’s not an easy city and that’s one of its charms. Heh, though people generally don’t talk about Detroit’s hardships in terms of biking to your tech job.
Some large services do use the actual dumps, and correlate them with the email address associated with the current user, in order to give users a personalized warning that they're reusing a leaked password that's already associated with that specific email address. This is a much different proposition from forbidding that specific user from using a half a billion passwords.

A full 80% of the v1 corpus can be avoided by simply requiring a minimum password length of 12. As Troy has pointed out elsewhere, this wouldn't be great UX, either. While it would dramatically increase the chances that they came up with a word that would be A) not in the existing blacklist, and B) harder to attack offline ... it would still be significantly bad UX compared to the best-practice alternative that I lay out in a separate thread branch.

But it would still be much better UX than use of the full blacklist.
> I believe it is true because otherwise the movie maker would be sued like crazy if it was a lie.

That's a truly terrible standard of evidence. The fact that a documentary maker hasn't been sued isn't evidence of anything.
> There isn't a human alive who hasn't been taught most of what they know by other humans.

This was my first thought. Self-taught humans aren't that great at dealing with the real world either, so expecting self-taught computers to be awesome at it seems a little unfair.
Fair enough; that's a good point. I'd still argue, though, that gofmt isn't doing what people expect pretty printers to do. Long lines are some of the most common style violations in most projects.
in my experience traceability of the versions of the dependencies used is as important as tracing that you use them... having that all in source control and being to replicate an immutable build from that tag at any time in the future is useful especially for large and complicated projects.
Long story short? Don't use shitty registars. And that cute two letter extension? Don't use that either.
> This shows me that you aren't actually reading what I'm writing.

> What is my claim? Based on the above you don't seem to have any idea.

After your comment on me not engaging in discussion and not understanding what you said I actually sent this thread to someone that is professionally trained in debating to gain better understanding. There is no point in being right on the internet, and a learning opportunity is always worthwhile.

The professional debater I sent this thread to got the same impression as me on what your line of argument was and suggested I respond in the way I did. If you mean something else then I am therefore not the only one at a loss, and like me I suggest that you introspect so that you can improve. Show this thread to someone you trust to be good at discourse and get feedback. We are all fumbling when formulating our thoughts and that is ok. What is not ok is to act rudely.
You should never use only 2FA for something you don't want to be locked out of. You need a 3rd authentication method to replace the 2nd when you lose it, such as backup codes, that as well as a 4th one to recover a lost password.
Interestingly enough, Kanye West had a nearly identical religious experience and breakdown, down to witnessing a divine pink beam.

https://www.washingtonpost.com/lifestyle/style/philip-k-dick...
Yes, as a software dev, this would be something that I am interested in. Though as others have noted it might be better for existing remote friendly towns to simply try catering to this group more. One example that comes to mind is chattanooga and their gig municipal broadband.
Great to see you guys doing so well. As a BCOV'er, we really miss you guys!
In the same spirit, our lab is experimenting with a new approach to scientific publishing via Github: https://twitter.com/AndrewGYork/status/965765089373515776

No paywall, no delay, straight to the web. Open data, open code, interactive/animated figures. Transparent, rolling peer review, version control, CC-BY license, citable DOIs. I was worried no one would read it, but it turns out science twitter is awesome. Very positive experience, so far.
This is why I configured my dovecot instance to use - instead of + for the mailbox delimeter
Please link to a tag of the repository, not master, or else the docs may shift out from under you.

https://github.com/rust-lang/cargo/blob/0.25.0/src/cargo/cor...
Yes, but the actual education is carried out by the au pair. Like it or not, if she doesn't like your decision, she may act otherwise. Execution is more important than decision.
by the way, i can sympathize with your experience. i have been through wonky recruiting/interview pipelines myself. hang in there.
Which profiles / h264 settings? I know that YouTube prefers "streamable" files, which I've never really understood.
I think this is a passage from Valis. Was Dick being slyly autobiographical in that book?
Regarding your last statement- while doing these things help, the lack of doing these things isn't necessarily the cause of the problem.

I know that plenty of programmers have never contributed to open source, nor written a single line of code outside of work, and they still have no problem finding or maintaining jobs.
Warned about what? You didn't answer his questions or explain what you meant.
Nautil.us seems to have a tendency to publish pesudo sciency article with grand claim and irrelevant random thoughts.
Those are great questions.

Especially provocative point about how mobile devices would most likely be leeches in a p2p world. The world wants easy to use mobiles. A system like this may need to constrain leeches. There will be some tension serving both goals.
I found myself with brogrammers that had 0 engineering style hobbies

What is an "engineering style hobby"? I work in the SF Bay Area, and the most popular hobby of my coworkers is "parent".
Get started with Salt
Show HN: Paste a text with your (not big) life problems and use EMDR
Some people have different views of what work should be. Don’t need to start name calling.
I assume it is this, doomsday paranoia. (just because you're paranoid doesn't invalidate the thesis)
I just kept all my old drives. Really should start transferring to newer ones, some are pre-IDE, and hell, idk if i still have an ide/ata interface, much less the older interfaces.

I recall there being a wave of hdd failures in the early ipod hard drives (yes, they really did have spinning disks). Amazing so many still work at all.