skysight-inc/HackerNews huggingface dataset:
"Here we argue that vaccines are less vulnerable to pathogen evolution than are antimicrobial drugs because of differences in the way drugs and vaccines work. We contend that two key features of vaccines have large, synergistic effects on the rate at which resistance arises and then spreads"

"(a) Timing of action - For most infectious diseases, hours to days elapse between exposure to a pathogen and symptomatic infection in a host ... Pathogen replication during this incubation period creates opportunities for mutations to arise"

"(b) Multiplicity of therapeutic targets within and between hosts - The benefit of combination therapy is based on the premise that resistance can only be acquired by the simultaneous acquisition of resistance to each component drug. The probability of simultaneous acquisition becomes vanishingly small as the number of drugs increases. A vaccine, however, often exposes the host immune system to multiple pathogen proteins (antigens), and multiple potential binding sites (epitopes) on each antigen. Epitopes are recognized and bound by components of the immune system analogously to how biochemical molecules would interact with a drug or its downstream products. This means that immunity is in effect acting like combination therapy, but with substantially more component effectors (and hence targets) than any drug cocktail."

------

"One set of differences between vaccines and drugs stem from the fact that vaccine effects are mediated through host immune responses while drugs effects are mediated through chemical pathways"

They discount this as being a major factor but the only evidence they provide is that "resistance is seen against drugs such as solfonamides that also act indirectly."

It could also be considered that the immune system is adaptive and its capacities evolve during a person's lifetime and that the collective immune system within a population group evolves depending on the spread (or lack there of) of disease within the population group.

With vaccines we are triggering the evolution of individual and group immune systems in ways that we don't fully understand and so unlike with drugs where once resistance is formed we have to develop a new drug, individual and group immune systems continue to evolve even if the vaccines don't change. The same vaccine administered now may be triggering different responses than it did 100 years ago.
We, the people, need to address this. We mustn’t rely on government as government is always self interested with the interest being toward the top of the hierarchy.

Without education, our community will have serious problems.

Let’s fix this now.
I had CS classes but in my work I do 80% front (because I enjoy it actually) and 20% back. Not using anything fancy in my work though. So how does one avoid being classified like you do ? (well you edited, your original post had Just call it "frontend dev"., but my question still stands, how can I counter the prejudices you seem to have ?)
Yeah, they could have allowed filtering by language like Tagalog (something learned) rather than race or "nationality", which would have been just as easy. The other place I can see them doing this is Brazil, and there I'd admit that European vs South American Portuguese would be different. People like to segregate though...
> Which law are they breaking at this moment?

Fuck if I know, I'm not a Federal prosecutor.

Point is, it's not hard to draw a line between legal history (United States vs. Microsoft) and various software giants and their practices.

We've got a collective short-memory.
When I was in Kolkata a couple years ago, the sheer level of noise was quite impressive.

I would not want to live there, for a variety of reasons, but that is the biggest one.
Yeah, I don't get it. Is Pilipino a race? Isn't it a search by country of origin, or ethnicity or whatever, not race per se?
The mechanism for breaking up the companies would be new laws. Yes, it's generally considered fair for democratically elected governments to draft legislation regulating companies.
Much work is being done on Wayland compositors and window managers to change this. Among other expected results are also the security aspects where the user is able to know which program is reading certain inputs and outputs, and might be able to control this data. As a basic example, a desktop app is only able to read/write the pixels inside the rectangle assigned by compositor, and it only receives keyboard events and mouse clicks that were sent inside this rectangle. I think this is an assumption one could make about a modern desktop. Sadly not enough users care about this type of security, so we stick to the old, X11 style of altruistic desktop computing where every program can see everything.
I think the main focus here is to not hurting yourself rather than "focus on the flaws".

I mean, if something is harm to you, you may need to consider stop doing it before you been damaged permanently. Reduce the volume in this case for example.

It's not saying you should stop listening music or enjoying your life, but you need to protect yourself from been hurt by doing those. After all, how can somebody listening music after became a deaf?
Just How Did Sonic 2006 Happen?
Worry not, dear author! Being mindful of your inner-ear health is certainly a good habit, but (moderate) hearing loss is not as scary as you might think.

I have oteosclerosis with accompanying inner-ear damage after stapedectomy or -dotomy, I forgot. I lost 10-20dB on one ear, 20-40dB on the other. I am amazed how much psychoacoustics save the day. Music does feel a little different, but it is no less beatiful to listen to. In some pieces I discovered brass sections I never truly appreciated, but most songs did not change by much. More importantly, my kids and I are still able to sing together as before.

The bothersome bits about hearing loss are having to ask "could you repeat that?" a lot, not hearing quiet sounds (kid's breathing at night, oncoming cars at a distance), and being more sensitive to loud noises. But so far, music stayed beatiful.

ps: If anyone from Netflix is reading this, it would be amazing if I could set a N-second delay for subtitles so that they don't spoil the jokes for me and everyone else. Even better would be if I could view them on my cell phone while we all watch on the big screen. I don't need subtitles all the time, just occasionally, for the bits I didn't understand.
Even the usual car parts stores (Autozone, Advance auto, etc.) stock a lot of parts going back at least 30 years. My car is over 20 years old and I'm surprised how many basic parts I've been able to just walk into a store and buy (radiator, alternator, starter, etc). The amount of warehouse space in those stores does not seem that big but they manage to keep a very useful selection of parts spanning several decades. Much more convenient than going to a dealership and paying 3x the price and waiting a week because they don't actually stock the parts anyway.
> And then we have XMPP which doesn't support things like video or voice calling

The Jingle extension is about a decade old and it's what Google based its support on. They even played ball for a while and released a good quality open libjingle, then decided that fighting spam from the other open XMPP networks is not worth their time and killed the whole openness concept - despite being an orders of magnitude simpler problem than email spam.

I think now the only escape from the walled gardens is regulatory pressure forcing interconnect of the larger players (Facebook, Google, Yahoo etc.) at least at text chat level.
Why bust it up? Just don’t use something if you don’t like it. Vote with your wallet.

More regulation means more government power. They are more powerful then all the tech companies you listed.

Why give them more power?
How and why we moved to Vue.js
It’s funny you said that.

One of my colleagues pointed out that the IM client from Exchange 2003 era (I think it was Live Communications Server) and LiveMeeting were a better collaboration platform than SfB, even given the severe limitations on bandwidth and cpu.
It's not exactly what you're describing, but to see an example of a video conference running within a Matrix client...

https://youtu.be/y0-j4Q77KXM?t=14m47s
property markets still collapse. Towns turn into ghost towns, it’s not bulletproof. The absolute safest thing is cash in a bank. It’s an absolutely terrible investment, and you’d be an idiot to do it, but it’s safe.
One Cause of Market Turbulence: Computer-Driven Index Funds
The Sacred and the profane
You can't build a BPM using a BPM, however there is a time and place for a BPM.
> A programming language is not supposed to match human intuitions.

I'd say that's a flat out false conjecture. Given a choice between two programming languages, one which better matches our intuitions and one which doesn't, the one which does will always yield programs with fewer bugs because we will simply be better able to express our solution to the problem being solved, and we will be better able to understand the program and so extend it.

It's like saying that door knobs are not supposed to match human intuitions, they're just supposed to open doors in the best manner possible. Well guess what property opens doors in the best manner possible when humans are the ones opening doors? A door knob that's most intuitive and natural for the majority of humans to use. HCI and ergonomic factors are seriously underappreciated in computer science.

> you really need to understand the spec fully and experiment with every paradigm in production to claim that JS is a poor language. Can you genuinely say that you have?

I've used OO, FP, prototype-based, logic and constraint-based programming languages. Yep, I think I can say JS is not a good language. It's improved somewhat, but still not great. It's not Brainfuck-bad, but it's not particularly good either.
And yet probably 95%+ of the content will just be entertainment to us, not used productively.

Maybe for all of you fortunate to work in tech get professionally useful info here?
The USA now evaluates monopolies based on just one thing: their ability to control and manipulate prices charged to to household customers. Using market power to raise prices to household customers, the way Enron did to California electricy users, is against public policy.

The anti-trust dismantling of the tech behemoths advocated by this author cannot happen unless public policy changes so it also discourages monopsonmies. https://en.wikipedia.org/wiki/Monopsony In other words, companies like Amazon and Walmart don't increase prices to their customers. Instead, they have power to decrease their payments to suppliers. But that's not against current US public policy.

Also, I wonder about the wisdom of using market cap as a measure of a business's size. That's a peculiarly sili-valley way of measuring things, and can be very inflated. Take Uber. It's a pirate (informal) cab company with an excellent app. It loses money every year. Most cab companies would run out of gas if they did that. But not Uber.

It may be better to measure company size by revenue or even, gasp, by size of payroll or by profit.

And, the word "firm," used by this author, is jargon from the academic field of economics. It's a tell about theoretical vs. real-world advice.
The argument is certainly not attempting to be rational.

If you want to break up Apple due to its economic power, then you have dozens of other corporations to slice into pieces. How? Who knows, some bureacrat with likely zero relevant qualifications will get to decide.

If you take apart Apple, then you have to rip apart:

Berkshire Hathaway, 3M, Johnson & Johnson, Caterpillar, Intel, Oracle, Cisco, nVidia, Netflix, Adobe, Activision Blizzard, Priceline, Exxon, Chevron, Pfizer, Merck, Amgen, AbbVie, Abbott Labs, Gilead, Qualcomm, Broadcom, Lockheed Martin, Visa, JP Morgan, Bank of America, Wells Fargo, Citi, AT&T, Verizon, Comcast, Procter & Gamble, Coca Cola, Pepsi, Kraft Heinz, Walmart, Costco, Home Depot, Lowes, McDonald's, Starbucks, Nike, DowDupont, Disney, Boeing, CVS, Walgreens. I'd add GE to that list, but they've decided to take care of it themselves.

You also reasonably have to start dealing harshly with similarly massive corporations HQ'd outside your jurisdiction, when they attempt to operate within your borders. Whether that's SAP, Toyota, Alibaba, AmBev, etc.

Now, on some of those, without question, a large audience is shaking their head yes. For example, the big banks. There is a large segment that overwhelmingly thinks they need broken up. How do you forcibly break up 3M, Boeing and Home Depot? That's just begging for disaster.

Then after you're done screwing with the economy, you have to pass a law that prevents nearly any acquisitions, so the giants outside your borders don't just scoop up the now weaker smaller entities and so that new giants never get constructed again.

Good luck.
Interesting. I often ponder how to approach creating a training set for a match making AI. It seems like the most difficult part is getting long term feedback. Analytics on first date compatibility would be easy, but metrics on long term relationship success would be very difficult.
I found it horrible, clients are Electron monsters (but still bo Linux version..) that they shove in your face whenever you try to use the web version.

So far I can stick with Lync/Skype for Business at my day job, which is bad too but.. slimmer, and does the job. Most of the time.
Compensating for something.
https://jmp.chat/ is a good alternative. Text and picture messaging over XMPP, and voice over real SIP (with voicemail transcribed to text).

There are lots of great XMPP clients, such as Conversations on Android, and Gajim or Adium on desktop. Or use https://movim.eu/ if you like a web client. iOS has a few options as well, including Tigase Messenger and IM+.
What options do you have available besides running for office in Oklahoma or leaving Oklahoma? Making up the difference out of pocket? That reinforces the bad behavior of local government.

If your problem is with the government, coordinate to fix government through elected office.

Worst case scenario is other states (that can pay teachers a living wage) recruit teachers away en masse, which is unfortunate for Oklahoma residents but the best outcome for those teachers.
I thought it was by 70% by delegate count, but yes it looks like 62%
Thanks, I think I've used that before but I hadn't bookmarked it yet.
That's clearly not viable, as displayed in the linked article. One of the examples of a good use for this was 1Password reading QR codes from a browser. Additionally, how would screen capture software work?
KhanAcademy?
Not a hacker but definitely came a long way. Boils down to one thing for me:

- Raw motivation. Be like a pig in the mud, "really" enjoy doing it. While everyone else considers it work.

If strong motivation is there then logistically you might also need things like:

- Persistence over the long run. This shit takes years. Choose the hard way if it can teach you more. Read the source. Practise ruthlessly.

- Optimize your rate of learning. Understand your weaknesses and use that to become faster. Be methodical.

- Optimize your work and life environment. Your goal should be to be in the zone, focused and productive. Things that can help: excersise, minimize distractions, stable/no relationships, have basic needs sorted, etc.

- There are many many disciplines that you should explore and work in.. algorithms, code optimization/perf, architectures, security, etc. etc. At work, university and online, there are people that can teach you things and guide you. Try and find these key individuals.

Just a few points from the top of my head.
Embarrassing. People in the rest of world must think this country has lost its mind. Perhaps we should go ahead and eliminate all taxes and see what happens.
What to consider when creating pie charts
I read it again. The author does say that it strikes her as a version of the barber's paradox, but also says that most critics invoke the liar's paradox. I don't think she's shown clearly which it's closer to, but your point is taken.
I second your Netflix suggestion. I can't watch dialogue-driven comedy with subtitles on, due to the timing.
I don’t think so. Cisco maybe, but Microsoft is printing money with this tech.

Capturing email, files and love communication drives subscription revenue for E5 SKUs of 365, plus most companies will need Azure AD to meet their security and compliance requirements.

We ran the numbers at work... taking the blue pill and going all on Microsoft will 3x our lifetime value to them vs a standard E3 shop.
In many cases, there's no choice, unless you're willing to accept a certain level of inconvenience, or a monetary cost.

Need a phone that is reasonably modern? Google or Apple, that's your choice.

Need to stay in contact with a diverse and spread out group of friends, without manual mailing lists? Facebook is your choice.

Sure there is actually a cost, but it is invisible to most people.

It is borderline impossible to live a reasonably connected life today, without at least one of the big four, and probably most of them.

Big companies basically own the US government.
In the press conference after the Falcon Heavy start a journalist asked the question of how much the investment was. Elon answered “around half a billion [silent for 1s] propably more.”
That's technically and conceptually easy but it costs a lot of money. One approach would be to put a large DC-DC converter on the car and run a 48V bus next to the 12V one. That's a very expensive device, needing to be perhaps a few kilowatts depending which devices are on 48V. It's also a lot of extra wiring, and the need to manage the extra variations in vehicle systems.

A second approach would be to put a DC-DC converter only in the devices that need 12V. But that's asking every supplier to change their design to accommodate 48V and the vehicle manufacturers will bitch about the cost increases. It'll be a moderate increase across a LOT of devices.

I'm working on a product that uses a highly integrated SoC that has all the regulators needed to connect it directly to the 12V line (it'll run on 6-20V or so). It even has an on-board 5V regulator for additional off-chip devices. The best thing for us would be if the same chip existed but could be connected directly to 48V (not sure what the range is on that) but from a silicon standpoint there is a big difference as well. Adding an external regulator would add cost, and invalidate some of the wake-up features and low current standby capabilities of the chip.

There are always "reasons". The only way to make the transition is for someone to make it happen, but again the suppliers who participate may be seeking premium pricing in the beginning because there aren't options.
I'm working on a lightweight native client for all major messengers:

https://eul.im

It's only 90 KB (!)

Right now there's an old barely usable alpha out, but a new release is coming up next week.
No, you can change the number associated with your Telegram account.
The original article: https://www.economist.com/news/united-states/21736102-low-te...
I know. I'm happy it's winter in Denver now, because the amount of motorcycle traffic is so much less. The noise motorcycles with pipes produce is right up there with emergency sirens.
hello -- forestry.io looks great, but I had a big problem with it -- there is no support for MathJax within my markdown posts.
I had math equations within double-dollar signs and the forestry.io editor removed them, making my math-based post render badly. Looks like there is no support for MathJax. I find it hard to see why forestry.io should mess with the MathJax in my markdown file -- why not leave it as raw text that I can edit?
Nitpick: don't conflate conglomerates and other corporations, like BH and Apple. BH owns a lot of smaller companies but themselves don't do much as a holding company, whereas Apple is one big company that does a lot directly.
A tale of performance debugging: from 1.3 slower to 48X faster than Apache Kafka
I am a full stack senior with quite some years of experience. I use the internet when I have the tiniest bit of doubt about any of these questions. To get my app right and have fewer bugs I tend to use my own memory less because it's simply not reliable. Another reason to look up things is that standards change over time.

Why would you need a handbook like this in the first place? Clearly because your memory is not reliable. So the interviewer acknowledges his own poor memory, using this handbook to find a candidate with better memory? Oh my..

I know hiring is hard, but this doesn't cut it at all IMAO.
Lessons in containerising a cron job
I have a small art collection of small pieces of art by local artists. I generally get them at open studio events or local art fairs. I don't have a lot of wall space.

The ones not on the wall I rotate displaying on a little stand that sits beside the door when I leave.

I enjoy them and they seem to lift my mood.
Hearing loss is one thing, but the tinnitus that often goes with it can at the worst destroy your career and your life (people do commit suicides because of it).
No, you can do the complete setup with the Telegram desktop app, but you need a device which can receive SMS or a phone call.
Using Sam Harris as an example is way too charitable to the average person.

Most people are not first-principles thinkers about politics. They are self-interested. Where that motivation is considered unsavory, they will deny it, even to the point of deluding themselves. Race is a prime example, because, like all forms of identity, everyone is biased in favor of their own ingroup, but admitting this bias is far more stigmatized than admitting other forms of ingroup bias.

If you take nearly everyone in the United States at their word, then racism has been effectively wiped out. And yet the indirect evidence of it is everywhere. Which means people aren't being honest with others--and possibly even not with themselves--about being biased in favor of people who look, speak, and act like they do.

This gets even worse when we start talking about politicians, who are trained to routinely lie, to the point where the media starts to safely, and correctly, assume that what they say is motivated entirely by self-interest and completely detached from the truth if it deviates in any way from what would advance their self-interest.

Notably, politicians who buck this trend--Justin Amash, Bernie Sanders, Thomas Massie--aren't generally stigmatized by the mainstream media as self-interested troglodytes. Their views are criticized, surely, but few question that they genuinely hold those views from first-principles reasoning, because they've demonstrated that they're principled people.

This suggests that the media is actually pretty good at distinguishing troglodytes from the truly principled, and while that may rub off on people like Ben Affleck the wrong way, directing your hatred at "the media" is misplacing it.

Also, the guy who wrote this article wrote a conspiracy screen about Obama's "plot to overturn the 2016 election" literally two days before. So him calling out others for impugning their political enemies' motives as coming from bad faith is pretty rich.