skysight-inc/HackerNews huggingface dataset:
> This will lead to a massive rise in availability of human eggs for scientific research, accelerating many fields.

It will also mean a massive rise in the availability of human eggs for turning into embryos, which in turn will mean the ability to be much more selective about which embryos to to implant during IVF.

Currently egg harvesting is such an arduous process that embryos can only realistically be selected for viability and a handful of generally fatal diseases. When you are choosing 1 out of 7-10 embryos, you can't be all that picky. But between having access to hundreds of eggs, sperm obviously not being an issue, the ever decreasing cost of genomic sequencing, and the ever increasing knowledge of how specific genes relate to traits, parents undergoing IFV could start to apply many selection criteria. That wouldn't be genetic engineering in the classic sense, nothing would be available that wasn't in one of the parent's DNA, but it would get a lot of the way there.

Edit: If I was going to be beaten to the punch by anyone on this subject, I'm happy it was gwern.
You do toss someone a couple hundred million in private equity for an immediate end to the damage to the company's brand, legal fees and recruiting efforts.

If Uber was in any real jeopardy of being found liable here they would have settled for far more. We know this because if Uber lost the case outright they would face an injunction against their self-driving business that would probably force them to license Waymo tech or put an end to the whole endeavor. Uber ATG is worth a lot more than what they paid in equity, and this is not an amount that matters at all to Google. The dollar figure is just there so Google can say they didn't come away with nothing.
HelloSign (YC W11) Is Hiring Its First SFDC (Apex) Engineer. Remote OK (US Only)
Auto Clicker Mac
This isn't true competition. This is vertical integration.

Amazon isn't offering to deliver Walmart packages for a price.
Edgewood Arsenal human experiments
There used to be Facebook lists (NOT groups, lists are a private sorting friends can’t see). I would make a list of friends I most want to follow and open just that list. But that feature seems gone (I also used list to limit friends visibility and access to my wall... honestly google plus has this right)
GKS – The First Graphics Standard
A proposal for “.md meets JSX”, mdx
I agree. I think the Oxford comma is a necessity; but so far as I can tell there is only one grammatically valid parsing of the sentence.
Coingecko has been tracking this too, for example https://www.coingecko.com/en/coins/ethereum/developer
Five major psychiatric disorders have overlapping patterns of genetic activity
> If I need to look at a calendar, I'd typically open a, you know ... calendar application.

Years ago, Mozilla created a calendar application called Sunbird [1].

[1] https://www-archive.mozilla.org/projects/calendar/sunbird/
No... Knowledge of money
It never ceases to amaze me that there are people who own pugs, yet refuse to eat a GMO tomato.
Forgot to note that fortnite had an ongoing "friend list" problem before

Most notably, whenever you wanted to add someone to your party. You had to do the following.

1. You Send user friend invite

2. User would have to accept invite

3. User would have to disconnect to refresh your friends list (due to friend-service issue mentioned in blog)

4. User would relog back on (took approximately 3 mins)

5. You could then see them on friends list

6. Send party invite
The industry lobbied for them, and there was no workers' union to tell the other side of the story.

It seems to me like the intent is to avoid economic waste due to spoilage of perishable goods that might otherwise be sold, but for a dearth of timely labor.

It also seems like the burden should be on the employer to hire more laborers if they have need of more labor, or to demonstrate some reasonable level of urgency that would have prevented hiring.

Since this suit covered years of unpaid overtime, it is clear to me that someone bought themselves a "F U" law that only benefits their own selfish interests, at the expense of someone else. It is likely responsible for the failure of the business to hire an additional permanent driver employee, or to ever employ a contractor to pick up the slack during rushes and crunches.
> I have a $1M antenna near field scanner at work.

tingle

Just add if one thinks a bit one can find a lot of industries that depend on renting out expensive capital equipment. Consider a taxi. A taxi might cost $25,000. Smog machines that auto shops have are not cheap. An Boeing 787 costs around $600,000 a seat. Rent a hotel room lately?
Olympic athletes are known to sell some of their team clothes after the games. I overheard a well-to-do family at Mammoth saying they bought the jackets off some US Olympic ski team members who were broke.
If we extrapolate this into the future, we'll eventually have, "Escaping data from Computers through an Event Horizon."
There are a bunch of other new ones as well, such as red haired man and pirate flag. Cool!

https://emojipedia.org/emoji-11.0/
> I don't think people notice how difficult rollback is.

Yep, while we always had a plan in release/upgrades for a fallback, everyone knew it would never happen.

We had enough testing in qa/preprod that no matter what happened, a fallback would cost much more time and money than any methods (manual or otherwise) to rectify the problem.
Was coming here to post the same thing. The vans in my area are unbranded, the employees unprofessional and the delivery is sloppy. "Soft" expenses such as uniforms and paint make a difference on perception, as would better supervision and training.

I also wonder, in the drivers' defense, if the delivery schedule is unrealistic. I can better understand lobbing a box on the lawn if you're 10 deliveries behind.
The point of overtime pay is to incentivise employers to employ extra workers instead of overworking the ones they already have into the grave. It doesn't matter whether it is expected or not, unless the job intrinsically requires overtime and cannot be done by hiring extra workers. So exceptions for trucking, perhaps, but exceptions for "packing for shipment" are definitely total bullshit!
Hrrm. Gave it a spin with a HDR 4K video on a non-HDR screen with default settings. Washed out, over-saturated, unwatchable colors.

Tried finding tone mapping options. Apparently, those are only available for the OpenGL for Windows output. Changed to that (automatic is D3D11). Great, nice colors.
Full-screened. Then back to windowed. Crash. Happens on many (but not all) 4K HDR MKV files here.

So yeah, not really working at all that well. Back to Potplayer for now (I had been using VLC for years, but for 4K videos it just wouldn't work all that well).

Nice on the Chromecast features though! :-)
Facebook still has lists. It's a little convoluted and only really works well from a desktop/laptop browser, but they're there.
I feel like so much of these conversations lack the high level questioning around why IVF and related technology has become so prominent and increased in usage. Is the rate of fertility problems increasing? And why?
American Spies Paid $100,000 to Russian Who Wanted to Sell Material on Trump
- human eggs - check

- artificial uterus - check

- human factory - pending
There are not any clear signs. Normal flu is the same as deadly flu, until it is not. That is the frightening part. We are helpless against bad luck.
I would be surprised if the bank complained. They are only on the hook for $250K per the FDIC and could cover it with a low interest interbank loan from the FED. Since their mandatory reserve is only a fraction of the cash on deposit they will happily leverage it for greater returns paying you your paltry .7% while collecting much more than that.
I'm more relying on my experience in trading with Goldman and other banks than I am assuming anything. I also don't see where I said anything about zero sum games.
Other problems remain, such as genetic degradation and questions about epigentic content.
There are many use cases for reliable, long-term storage. This is why some places still use microfilms.
This could be a product by itself, and finance the whole enterprise.
What's the reason for thinking the gains are unbounded? AFAICT we could reasonably suppose something like 50 IQ points is within reach via embryo selection, but what would a something like a 300 IQ even mean, and even if it does mean something tangible, why should we assume that's biologically reachable in the same way that a 150 IQ would be?
There is no evidence Uber has any trade secrets from Waymo that they would have to stop using. That was why Google settled. If Uber did have any trade secrets they would have lost the case outright.
I agree with you, and I think your experience is more typical than you may think.

It's a chore because you often get zero positive validation out of it (ghosting, relationships that go nowhere, blah blah)... You begin to not want to "play the game" which is what I'm reading from your post and I very much relate if that's the case.
A couple of things:

I can't manage to copy and paste it from the article, but one section talks about these guys hiring friends and family, not for their expertise, but as a favor. This inevitably goes bad places.

The old boys club is about knowing you well enough to vet you on two things: 1. How trustworthy you are generally and 2. What you are good at.

Having connections matters and if you can't establish those connections, you will go nowhere fast. But when it is at all healthy, establishing those connections is about vetting you. These athletes never got the memo. They haven't learned that the reason you hire someone you know is because you can literally trust them with your life, not because they need charity. If they need charity, give them charity. Don't entrust your millions with them.

Second, I really appreciate the section where they talk about divorce and that it often happens after retirement in part because these guys can no longer avoid the hard conversations. A lot of marriages seem to only work in X circumstances and to fall apart if circumstances drastically change. The two people are compatible as cogs in X machine, but the personal relationship isn't really that strong. They don't adapt well when that situation goes away.
> THROUGH an in-series LED

That's a pain electronically since the brightness of the LED would vary depending on the current drawn by the camera and/or microphone. In order to not blow the LED, the circuit may have to be set such that the LED wouldn't be bright enough to notice reliably when the camera is in a lower power (but still functioning) mode.

You could easily get what you actually want by putting an LED in parallel with the power supply to the camera and/or microphone though. Then the LED would maintain a fixed brightness but wouldn't be able to be switched off unless the power to the camera/microphone is cut.

Separately, it's possible to have unpowered microphones. I suspect laptop microphones are of the unpowered type (and amplified elsewhere). It's still quite possible to have a circuit which is hardwired to be incapable of passing the microphone signal without lighting an LED.

I'm just saying that your "in series" demand is unrealistic, and instead you should prescribe what you actually want rather than specifying an electronic circuit that can't necessarily achieve it.
"The audience" was a western social media site blocked in China. Are we truly going to censor ourselves on our own platforms that the offended can't even reach?

I get that the answer is a capitalistic 'yes!', and I don't particularly have any love for the feudal Tibetan llamas but we do need to recognize what is happening here.
It's surprisingly difficult to come up with a syscall that is guaranteed to enter the kernel and come back out on a fast path. Old choices for this were things like getpid() or gettimeofday() which are now handled in the VDSO. This seems fairly clever, honestly.
Even then, the consumer of the package is still dependent on the security practices of the holder of the key. It's more secure, but still not something you can depend on universally as a consumer.

"I promise you can trust me" is not something you can trust.
Ask HN: Best way to advance your programming career only with small companies?
As a programmer, I have always worked for smaller companies. Mom & pop places, web agencies, early stage startups, you name it. Typical size is 10-20 employees. The largest company I worked for has 250+ employees among their offices, and it also had the most regimented work environment. I didn't stay there long for an unrelated reason (very long commute times).

While I'm not writing off applying to large companies, they're also the least likely to give me job offers, so I gotta be a realist and think about how to advance my career with small companies only.

That is, as a programmer, I want to develop the skills to become more of a leader and go-getter. At 35 and with 10 years of experience, I don't feel like I really grew much in my career. I have never lead a project, never guided less-experienced programmers. Or never even participated in interviewing others. Also, I am not interested in starting my own business, or doing another less technical role such as product/project management.

It doesn't seem as easy to move up the programmer ladder with smaller companies, because you can become a big fish in a small pond, but your responsibilities and capabilities could still be dwarfed by what lead programmers at larger companies have.

But it isn't impossible to do, right? Using small companies, to grow your skill set and reputation so you are actually growing in your career? What would you do in this situation?
You can get source rpms for say Centos or Scientific Linux and maintain your own set of patches and flags.

Minimise your deviation from the stable stuff that everyone else is using.
Robots can love.... https://web.archive.org/web/20170203093457/http://www-formal...
Even if you don’t think the product itself is novel, the technology infrastructure behind Facebook is absolutely novel, from the news feed to TAO, their massive graph database. I’d wager to say TAO is the highest throughout OLTP database in the world. They were able to get ahead of MySpace, the market leader, because their technology was vastly more nimble and reliable.
It is an extremely popular approach. It might not be the best way, but I’d argue it is the default for most people.
Run YugaByte DB in Kubernetes StatefulSets
For me, Mailspring (successor of Nylas N1) works, but it does use Electron... (Therefore IMO not suitable for mobile, but I wasn't suggesting that either way.)
Because IT workers make a lot more money than the average voter so they are more likely to be the victim of animosity than the subject of pity.
More relevant-to-HN headline:

American Spies Paid $100k to Russian Selling NSA Cyberweapons, Trump Kompromat
This Osmo [1]? Well, good for you. But this software is not capacitive/finger friendly. Its for resistive/pen usage. The rest of us need a mobile e-mail and PIM client which works with a capacitive touch screen (and fingers). Also, many do want online synchronization so that their desktop, laptop, and mobile phone are synced. You can even self-host with Nextcloud as an individual or company.

[1] http://www.clayo.org/osmo/
I'm starting to this we need namespaces for open source projects so we could refer to deep-learning:impala and database:impala. The java reverse domain name notation does handle this to a degree but I feel something could be done in this area to make the naming issue easier.
To be honest I more often have difficulties in telling the gender of black and asian people than caucasians solely by their face.

Edit: why downvote? It’s just my observation.
Bug: https://emojipedia.org/smiling-face-with-smiling-eyes-and-th...

I only want to express myself with 3 hearts, not 4, but now I'm being forced to use 4. This does not align with how I'm feeling. How insensitive.
It is sobering math to figure out that a million dollars is only about $25k a year for the rest of your life.

A million bucks will make the rest of your life easier as long as you don't 1) spend it all and 2) don't make yourself unemployable (injury, bad PR, etc)
What do you propose then? If you can't trust the person, then why trust them at all? That argument doesn't make sense.
My phone does a much better job of redefining "normal tasks" than it does solving problems I had before smartphones.
Man Subspace/Continuum was such a great game. I do recall issues with packet loss, but in general the game functioned really well even on my 33.6kbps modem with hundreds of players and pretty frenetic gameplay. It's not until you mentioned it that I realize how amazing that feat is.
I'd argue the reverse: that in software, very small errors can have vast consequences, but it's virtually impossible in many cases to tell what those consequences may be or where they'll fall.

The reason is that software systems are at another level of complexity.

The Space Shuttle is often given as an example of the most complex machine every built, with more than 2.5 million parts. The Airbus A380 has about 4 million parts.

https://www.quora.com/Whats-the-most-complex-machine-ever-bu...

The Linux Kernel, not necessarily the most complex software ever written, has nearly 10 million lines of executable code, over 12 million with comments, scattered over 36,000+ files.

https://www.quora.com/How-many-lines-of-code-are-in-the-Linu...

Google's back-end cluster and services are frequently given as the most complex software existing.

The full LoC in Debian GNU/Linux has been estimated as 324 million as of 2009. This is the stable archive, which includes somewhere between about 30k to 70k individual software packages (I'd have to do some digging to see what the count was for the stable release as of 2009).

https://unix.stackexchange.com/questions/111281/exploding-am...
Recording at a low (but still intelligible) bitrate and uploading it when connected to power would be pretty easy on the battery.
Maybe something deeply cultural in this. An American couple I knew went to China back in the 90s, to teach English. They discovered all they had to do to request say, more towels was to mention it aloud in their room. Must have put a bit of a damper on their love life.
Wasn't aware.. should probably watch that movie
Microeconomics: Theory and Applications
Hm... I am reading the replies and yet again I've grossly oversimplified the problem in my head :(
IMO the financial industry tries to make it seem so much more technical and complex than it is. Even for how an average person can invest money. A lot of people are perceiving it as such.
Yeah, or you just piss off (or just attract the attention of) the wrong person or group. I can't imagine Ken Bone envisioned someone combing through his entire Reddit history or Justine Sacco imagined her joke would lead to people tracking down her employer and getting her essentially blackballed from her profession. And that's just nobodies working with only public information.
Same for Blizzard with Battle.net chat.
It would be great to see performance deltas for AMD CPUs too, especially since Meltdown only effects Intel and AMD patches for Spectre Variant 2 are considered optional. I would also be nice to see a discussion of AMD's ASID and any differences it has with Intel's PCID when when PCID is addressed.
Mostly I just reminisce about getting then monthly print version. Those were the curated days when I didn’t need to worry about missing an interesting article.
You're right, the Bill of Rights only protects criminals.
The equity he received from Otto's acquisition was also clawed back because he was fired with cause. He ended up with nothing from Uber.
> Additionally, Battle Royale style games are the most demanding multiplayer games ever created.

I'd like to draw your attention to Planetside 2. A pretty recent FPS that was run a lot like WoW, with 3 'continents' and complete seamlessness on those continents.
Firefights where 100 people were actively engaging each other were an almost constant experience back when I played it.
I think there was a cap of 1000 players per continent. Those players could gather wherever they wanted. I'm pretty sure I was in some 300 player battles, and nothing but lag would prevent all 1000 people on a continent from going to the same base.

It has to be said that in the big battles (at around a 100) lag became an issue. I'm not sure whether this was clientside, serverside or both.

(There is also eve-online where recently there was a 'fight' with 5000 players in the same location, but that is a different beast from FPSes, and the main logic of that game is single-threaded)
No, NPM hosts the tarballs itself. A project is not linked to a Github repo at all. It's just taken for granted that the repository on the tin (if there is one) is what you're getting when you npm install.
in regards to sick time keep in mind that you do not have to tell your employer any health related information
I wasn't implying that, just giving him credit for a great quote.

> In an interview for the Huffington Post, Vincent Connare, designer of Comic Sans, said, “if you love Comic Sans, you don’t know anything about typography. But if you hate Comic Sans, then you don’t know anything about typography either…and you should get another hobby”.
Do you have any book recommendations? I have some younger relatives graduating from college soon, and although they are bright, I worry about their financial sense. I talk to them regularly, but something more concrete would likely also help.
Well, good. Really. I thought that it was likely going to kill him, so this is about the best possible outcome.
If you just need basic writing/drawing functionalities, there is xournal on Linux. It is extremely good at what it does. You can overlay images and PDFs too!
If you bind crux-kill-other-buffers[1] to a key, you might end up with a workflow you're happy with.

[1] https://github.com/bbatsov/crux/blob/master/crux.el#L496
Why would I ever want to split up that table into two columns? Maybe this works in a blog where everyone is an amateur, but any professional worth their salt would stay away from that in the business world.
(Full spec at http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1060&contex...)
If you dislike it this much, your colleagues and investors will probably be picking up on it. They might even be thinking what do we do with this person. How do we deal with the situation?

Maybe the best thing to do would be to have an honest conversation with your co-founders and investors. Explore your options. Including going part time.

Communication is important and most of us need to be better at asking for help.

Your co-founders and investors will probably be relieved when you bring it up. The hard part is starting the conversation.

For the VCs this isn't their first rodeo. They've probably seen this before and they would probably prefer a discussion and a transition out rather than a blowout/suprise departure.
Does anyone know what kind of microbe this is?

Sidenote: for a second I read "emoji" as plural, and envisioned a handful of different microbes (e-coli, amoeba, cyanobacteria, etc). I got excited that finally, 400 years after microbes were revealed to us, USB microscopes had so democratized the technology that the Unicode Consortium saw fit to familiarize us with our tiny fellow inhabitants of Earth, our distant cousins on the tree of life.

Hey, I can dream can't I? ;)
It's also because this isn't a problem well-suited for addressing by individuals. I doubt even Richard Stallman audits every line of code he ever runs on his computer, and I doubt most of us would want the extreme level of inconvenience that comes with living his life.