skysight-inc/HackerNews huggingface dataset:
>With that in mind, you'd expect that fast-changing environments would select for genes that increase mutation rates

I've seen the opposite in a bioreactor (about the most stable environment you can have). Variants slowly emerged and outcompeted each other until a variant emerged with a DNA repair pathway deleted. The spawns of that variant quickly out-competed the old ones and from then on there were ~10 dominant variants at any given time instead of the previous 1-3.

Because the environment was so stable, the genes did not need to "remember" previous states of the environment and were free to optimize for the current state. The way to do this is to increase the mutation rate, as you potentially delete old genes that are no longer necessary and create new genes that are right for the moment.

Edit: I suppose this points out a difference between "fast-changing" in a single direction and "fast-changing" that repeats states, such as seasonal changes.
Lesson #1 in why developers shouldn't be unilaterally in control of the packaging & distribution and why I hate "wild west" style package repositories.
I'm pretty sure I'm the only person in the world who can say this, but I've been working with SWI-Prolog as my home automation controller for around 15 years. Last year I rewrote the system to make use of a library to allow SWI to publish/subscribe MQTT messages for communication between the components.

Logic programming just sounded like it would make sense for describing the behavior of a home automation system, and I think it works well.
The original designers of the macro system absolutely had Scheme firmly in mind (source: I was there). The most telling giveaway is that the identifier for declaring macros, "macro_rules", is a reference to Scheme's "syntax-rules". As for a comparison, Rust macros have to jump through hoops to account for the fact that Rust has syntax (and types), and the Rust system isn't entirely hygienic yet (work in progress).
There are laws against driving above a certain speed. This is exactly the argument that was being made above.
Written about a scumbag who holds the ultimate divisive belief.
There are cars being sold outside the US as well. Several big brand car manufacturers try to make that car.

They’re just not good. Yet.
Ciena | IT Cloud Architect | ONSITE (Baltimore, MD) or REMOTE, USA | Full-Time

IT Infrastructure Enterprise Cloud Architect

Diverse existing and new business system workloads needs to move to AWS, Azure (or Oracle?!?!) clouds.
Large migration project.
Hands on cloud and automation experience required, as well as ability to drive discussions and vision at executive level.
Candidate would be able to get to Hanover, MD office easily. Either local or remote.

Ciena is a major network gear and software vendor, probably this message went over our gear to reach you. In addition to using cloud providers, they are our customers.

https://ciena.wd5.myworkdayjobs.com/en-US/Careers/job/US-MD-...

Copy me as well please pwarner@<company-name>.com
Amazon Web Services - Lambda | Software Engineer | Seattle, WA | ONSITE

Come and join Lambda’s backend data plane team:

- Software Development Engineer, Lambda: https://www.amazon.jobs/jobs/601562

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Police have also gained the hard-fought-in-court prerogative to screen candidates on the basis of intelligence, excluding anyone unusual in any direction. It creates a monoculture as opposed to an ecology of diverse intellectualism.
Microsoft | Software Engineers | Bellevue, WA | ONSITE | Full Time

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Show HN: Who is hiring script to filter and search
Cheap, fast and great generally don’t go together. Depending on the problem, you have to pick either one or two but not all three. It will be interesting to see how this experiment pans out in India. I wholeheartedly wish success for them because this is something we have to put behind our back before we enter the next decade.
IMHO I think you've hit the nail on the head. iOS main attraction for many users I know is the simplicity. You can complain all day about Apple's guidelines and iron fist enforcement, and I'd occasionally agree with you too, probably many times. Simple fact is though that outside the walled garden everyone complains about is a jungle of terrible UX, laggy interfaces, slow loading web pages dumping megabytes of trackers and advertising through a connection you're paying for.

I'm not saying the App Store is perfect, not by a country mile is it. I'm just saying if you compare it to the Play store, and the wider Internet, holy moly do walled gardens look nice.
Davos to Tech: Drop Dead
Even Dimon, Buffett, and Bezos Will Not Reinvent U.S. Healthcare
Well, the idea behind offering insurance is that you typically don't need to account for everyone claiming it at the same time.
My wife is a dentist so, using similar reasoning, I once asked her why people don't do this. She said the problem is that implants ultimately connect into bone and that connection fails over time -- your body is designed to renew the connection from jawbone to tooth but without a tooth it eventually degrades.

Edit reply to your edit: I am sorry about your teeth. It is amazing how dental education still isn't pervasive -- she gets teenage patients in Oakland who've never been told to brush their teeth and who will lose them all at a young age. Modern dentistry can work some wonders, so long term I hope you are doomed only to some discomfort and costs and not more severe problems.
I'm not sure an experiment with non-human mammals would give you much either. How would you control how much sleep the subject gets? Only thing I can think of is sedatives to put them to sleep, and stimulants or flashing lights/loud noises to keep them awake. And those all come with fairly significant side effects, to the point that I imagine you'd really just be measuring the effects of those medications on the subjects rather than the sleep. But this isn't my area, and this is based on like 10 minutes of thought, so maybe there are more reliable ways to control sleep with fewer side effects?
> coinbase already FDIC insures USD holdings

Which is totally irrelevant to the cryptocurrency.

> 3rd party insures crypto holdings.

Yes, approximately 2% of their crypto holdings, so effectively nothing from the perspective of a customer who loses funds if their cold wallets are attacked.
[unhelpful question deleted, in response to parent's edit]
Why join? Start your own, run it like you want it to be run, and not only will you have the reward of working at a healthy place, you'll also have the reward of enabling dozens of employees to live fulfilling lives.

I like to think that Jason Fried/DHH went to the bother of writing all these books and blog posts because they legitimately want to see more businesses run like theirs in the world.
You hate Java but you know JavaScript, then try React Native. You can create most of the applications using React Native which works for both IOS & Android. Or you can try Flutter which uses DartLang.
Sysco LABS | Austin, TX | Onsite | Fulltime | Director of Architecture, Senior Software Engineer, Training and Implementation Manager | Competitive Compensation

Sysco LABS is a technology-focused division within Sysco Foods ($55bil/yr revenue), dedicated to reimagining foodservice through innovation. An extension of Sysco’s longstanding commitment to deliver exceptional products and services to the foodservice industry, Sysco LABS leverages customer and market intelligence, data-driven insights and agile technology development to rethink the entire foodservice ecosystem — from farm to table to check. Sysco LABS’ innovations will improve everything from the ordering process, inventory, pricing and automation to the in-restaurant customer experience. Operating with the mindset of a startup and backed by the authoritative expertise of an industry leader, Sysco LABS’ mission is to enhance the Sysco customer experience and consistently deliver revenue growth, cost savings and new innovations through technology.

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ctrl-f: javascript, react, es6, enterprise, b2b, hospitality
As a, slightly facetious, addition. I think Rust macros are better than either the C preprocessor or C++ templates because they're so bloody confusing.

They require someone with a great deal of energy, knowledge and will to win in order to tease anything useful out of them. This, I submit, is a feature. It dissuades the programmer who believes they are better than they are from being too clever by half.

There are worse things in the programming sphere than crap meta-programming but it does have its own circle in hell.

I appreciate that the Rust team are working hard to spoil my happy idyll but happy I remain for now.
People used to do it in the past, I remember reading about a groom who paid for his wife to have all her teeth removed as a wedding present.
TRAIN BY DAY JOE ROGAN PODCAST BY NIGHT ALL DAY!
Well to be fair, the reason we're having this discussion now is because people have been watching and questioning the expansion of the Tether supply via its transparent blockchain.

Someone could probably argue this is a step in the right direction from the days of Mt. Gox and its complete lack of transparency.
This post has a bit of info about what class migrants report of the attitudes of their original classes toward the more privileged classes:

http://www.andrewlangman.com/articles/class-culture-gap.html
We got really burned, multiple times, by Twitter. After the first time, shame on us, right? Never again.
That’s a long way to go to just proselytize without addressing any of the previous concerns. You seem to be reading from the same script all of the “new accounts” use to boost cryptocurrency as well. Finally you claim governments can’t stop something which creates a cryptographically secure “paper” trail.

No.
Apologies to hear about your wife's cancer. Hope the best of luck fighting to fight.

For adjuvant therapies for cancer, I highly recommend looking into sulforaphane.

Dr. Rhonda Patrick has a tremendous corpus of scientific research and plenty of anecdata on the internet about how it is helpful and has helped others with cancer.
Sr. level software architect actively looking as of last week. Several interviews lined up and looking to move quickly. Full-time telecommute positions are strongly preferred.

Learning, exploration, and new stuff is good; kool-aid is bad.

Location: REMOTE; Orlando, FL; Kansas City (with relo); Salt Lake City (with relo); Texas (with relo)

Remote: Yes. I have been full-time remote for most of my career.

Willing to relocate: Yes, to some places. Warning that most tech hotspots would require stellar offers.

Tech: Docker, Kubernetes, LXC, SmartOS, Java, node.js, Haxe, Kotlin, Python, Ruby, C, and much more.

Email: hn@jeffcook.io

Résumé/CV: https://jeffcook.io/static/JeffCook-2018.pdf
Product designer with some front end chops, interested in working on design systems / design tooling / complex application UI.

http://ricksteeledesign.com

Location: Seattle

Remote: If the company is remote-only

Willing to relocate: To SV/SF or DC

Technologies: Sketch/PS/AI, JS/framer/proto.io/invision for prototyping, AE for motion, css/html (scss/pug),the occasional react.

Portfolio: http://ricksteeledesign.com

Email: In profile
I'm not familiar with Chicago, but do you mean a street like this [1], under Carl/Lake station? It has two lanes given over to parking cars, plus a parking garage in one of the buildings.

At Nørreport [2], there is no car parking, except a taxi rank for three taxis.

A little further away from the city centre, at Forum metro station [3], there is a little car parking, but still plenty of space for bicycles.

There are counterexamples — parts of London or Rome, for example, although these areas are often so compact that there's little reason to leave 500+ bicycle in one place.

[1] https://www.google.dk/maps/@41.8857466,-87.6305372,3a,75y,26...

[2] https://www.google.dk/maps/@55.6842867,12.5731007,3a,75y,204...

[3] https://www.google.dk/maps/@55.6822581,12.5516201,3a,75y,124...
Metricstory | Senior Full-Stack Engineer / FE Engineer (React) | Seattle, WA | ONSITE, Full-Time | https://www.metricstory.com

We are a seed-stage startup helping companies with high-value web traffic detect and diagnose problems and opportunities in their funnels.

More concretely, large online retailers have complex operations that span marketing, design, web development, and fulfillment. Mix together several teams, multiple marketing channels, a large product line, and a diverse customer base, and the data quickly becomes overwhelming.

Our goal is to use statistical and machine learning methods to find hidden issues and provide a shared workspace for resolving them (think sentry.io for e-commerce operations + beyond).

Who do we need? A couple experienced engineers to help build out our BE and FE infrastructure, e.g., a senior full-stack engineer (5+ years experience) and a FE engineer (3+ years/React).

What are we built on? Go, Python, React, Proto3/gRPC, Docker, Kubernetes, Postgres, Airflow, with more to come!

Want to learn more? Feel free to contact me at jonathan@metricstory.com or on LinkedIn (https://www.linkedin.com/in/jonathanmrhodes).
Yeah, that's a fair point.

I think factories and beans are a sign that object construction in Java is a mess. In the applications I work with, most calls to "new" are dealing with data structures (lists, maps, protocol buffers), and behavior-heavy business objects are a mostly static call graph. Not sure if there's a name for this pattern though.
It would leave too much room for fraudulent or abusive behavior. Would exponentially increase the time their claims/customer service team has to spend digging through refunds to sort the real ones from the bs.

As a bad customer: I don't like the drivers name - refund. I thought the driver was too slow - refund. I just want to see what I can get away with - refund.

Believe it or not, most people will exploit systems to the fullest extent.
I spent a summer in NYC a few years ago. While living in NYC I did get a flavor of higher class living with some roommates of mine. It really is true that there are unspoken codes and mores to follow, and it was uncomfortable when I didn't.

However, this is one issue that's hard to put solely on the foot of the rich or a broader system. Passing in many avenues, not just by class, is really deciding you want to be there and what the terms of your presence will be. It felt at times like trying to get into a club, if you look like you want in, you don't get in. If you don't want in, they let you in. You have to learn to look like you don't want it.

I think rather than teach young children how to hold spoons, or castigate the rich for yet another divide they were born into, probably we should just teach improv skills, confidence skills and encourage people to engage in open dialogue with others. Some solutions don't require us dismantling a system.

If the next time a rich person gives you an askance look and you immediately ask them to explain themselves, guess what, you just equalized yourself with them socially without having to learn which fork to use first.
There was one just last night in BGR. It even invoked Woz in the headline to imply there was something fundamentally wrong with the phone.

For more, Google is your friend.
You have to be licensed to fly an airplane. You have to log a flight plan. I'm not an expert in aviation but I imagine if your flight plan includes something excessively risky that endangers the lives of yourself or others, someone is going to question it.
Ask HN: What should I do with my life?
I'm a full stack developer and I quit my last job about a year ago after having a personal crisis that I've now recovered from. I've traveled some the past year but have mostly sat around not doing much.

I have no real interests other than hanging with friends and family and socializing. I browse reddit all day due to a lack of other things I want to do. If I won the lottery I don't think my life would change at all.

How am I supposed to figure out what I want to do for a living when I have no interests? I've tried many things in my life but I find them boring after trying them for a while. I have all the time in the world and a decent amount of money and I'm under 30 and healthy. I feel like I'm throwing away my life.

I used to have an entrepreneurial spirit and worked on a startup for a bit before I had my crisis last year and had to stop. I feel like the passion for that is gone now because there's nothing I'm interested in and want to work on.

What's my first step supposed to be when there's nothing I really want to do?
This seems like a good opportunity for people to recommend some excellent and well-researched podcasts for various topics.

"Hardcore History" by Dan Carlin is such an example and I wish it was easier to find other such podcasts of similar quality.
We lived for so long in a world where Javascript was so flaky and non-standard that wise programmers stuck to a lowest-common-denominator style. But now you can really take advantage of the language.

I'm writing a compiler in JS that uses higher-order functions all over the place and I haven't been bitten yet by language inconsistency or performance gotchas. So I think you could go a long way showing how to do the sorts of metaprogramming tricks that used to be only attempted in Lisp or Haskell.
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Artificial Intelligence Put to Work on Voynich Manuscript
Or you just say "yes, this trip was in the following dates and not during my claim, which you can see from (provided documentation or other posts you made)" (and you can also untag yourself from other people's photos)
You have to keep in mind that prices are, generally, not magical. The price is a balance between what people are willing to sell something for and what people are willing to buy it for. Of course that's elementary, but thinking about this will explain why drivers, in general, will not be well paid.

Driving is a low value skill that the vast majority of people have, and if they don't have - they can learn it rapidly. Let's imagine now being a driver was lucrative. Well you'd have a ton of people racing to become drivers, no pun intended. But with so many people willing to drive people around, it'd mean a shortage of work for all the drivers. And so somebody would offer to drive people for a little bit less. And that'd repeat on downward until we reached the equilibrium point at which not enough drivers were willing to go below.

There are some exceptions like truck driving where people spend hours and hours on the road driving vehicles that do require some degree of skill to manage. And so the wages there are still pretty decent. It's not just driving per se, but unpleasant work that requires some degree of skill.

Ride sharing apps bring market efficiency. If you're willing to drive for $x and people are willing to pay $x, well - why shouldn't you be able to? They're still centralized of course, but I think it takes us one step closer to decentralizing the entire industry which would be amazing, as it entirely removes the middle man and let's people simply directly offer and purchase each others' labor. Of course this ideal is pointless in this particular case as automation is imminent and will super-centralize the industry. Although there prices will likely be lower than even a decentralized market could offer.
What I Learned Running 1,000 Miles in a Year