skysight-inc/HackerNews huggingface dataset:
Is this gRPC the same thing as golang net/rpc referred to here: https://news.ycombinator.com/item?id=16170116? I don't think so but I've never used either one.

>seniorsassycat: I don't understand why AWS released Go support instead of binary support and I don't understand why they chose to rely on go's net/rpc [...] which encodes objects using Go's special [gobs] binary format
Show HN: GridFS style file storage for your SQL database
Homo Erectus, obviously.
I think that new approaches to doing drug R&D are always welcome and if you know of any particular interesting and useful approaches id love to learn more. The "bottoms up" approach you mention seems like it could be really powerful and definitely complementary to whats being done now. I have however seen a lot of approaches "sort of" like that not work that well. I also know of a lot of less quantitative approaches taht actually work really well, and thats how a lot of R&D is done today

I disagree w the statement that we'll never cure cancer w/o info on mutation rates. Many of the most impactful medicines we have were discovered without this kind of low level, quantitative info. Many through serendipity. Penicillin is the classic example. We have actually made huge progress in treating many cancers in the last five years. We can turn many melanomas from death sentences into relatively manageable chronic diseases, and a lot of blood cancers are being completely eradicated in some patients (at least for a time). We have a long way to go, but most of these insights come from triangulating various pieces of molecular biological and chemical information to create testable insights

There has been a move lately to more "genomic" medicine where you identify a specific genentic mutation, and target that to treat disease. Most diseases aren't that simple though, and these are rarely curative

There was also a move in the early 2000s to measure expression levels of hundreds of thousands of cancer genes to try to understand which ones would metastasize, how to treat them, etc. In some cases algorithms got pretty good at predicting rates of metastasis, but most didnt, and even fewer yielded clinically actionable insights. And I dont know of any drugs that were developed based on this work

The idea of the moment is the "liquid biopsy", measuring pieces of DNA or proteins in the blood, and using machine learning to correlate these "biomarkers" with risk of getting cancer or other endpoints. The jury is still out on whether this works to my knowledge, though frankly i havent followed the science too closely

No one is giving up, not in the least -- in fact more money is being invested into drug research than ever before. Its just really hard, and "triangulation" and insight are more powerful right now than purely quantitative methods. I hope that changes. But for things to change, we probably need better tools for collecting data before algorithms could be really powerful
Yeah, I submitted it with the original title (used the bookmarklet). It doesn’t let me edit it now.

How does one summon the moderators to correct the title?
Not exactly. We used to have to keep many more paper records, which are really hard to manually encrypt/decrypt. Those were easily available to law enforcement.
Hello, thanks I'll take this in mind. The resolution could be made to be accepted in milliseconds, and it should be simple to honor it with an error for example of 50 milliseconds or alike, but to get true 1 ms resolution requires non trivial changes to the system that must act like a real time scheduler in some way...
Selling the Future at the MIT Media Lab
$50M is a minuscule AUM for any ETF, especially one meant for trading (volatility hedged vehicles are not good for buy and hold). Institutional investors, Hedge funds, etc will not touch such an illiquid fund.
Things you might be forgetting when traveling
I made $2900, didn't even know it was a currency back in 2014 when I signed up
Speaking as a former hitchhiker who used it to travel through 39 states, it's actually legal almost everywhere. What is illegal is to stand in the path of travel of a roadway, and in some locations standing on the shoulder is also illegal. But on a sidewalk, onramp, etc, as long as you're not physically in the road, it's almost always ok.

Some exceptions being Utah, Delaware, New Jersey, and maybe another, where you're specifically banned from soliciting rides using signage.

Sadly, the best resource for seeing what the laws are in each state was digihitch.com, which went down in 2014, I believe when the founder passed. Quite sad, they had pamphlets for every state with relevant laws written down -- it came in handy a few times when police stopped me. They were always respectful, but I did have to clarify the laws a few times, since it's clear if read, but not widely understood.
Why? Is it really that impossible to spend a few hours without being able to communicate with whoever is taking care of ones kids? I don't think so.
that's a bizarre complaint for a brokerage. Every brokerage exists to make money on trades.
Why apt should use https
> 4. If the majority of citizens do not consider want to forgo their privacy for additional safety,

If only it were so ...

https://yougov.co.uk/news/2015/01/18/more-surveillance-pleas...
It is uncivil to try to gaslight one person for the sins of society, and I would consider it unethical to not call someone out for having done so.
> Why was no one ever so militant against advertising in newspapers?

Because newspaper ads weren't audio-video presentations that jumped over the text you were trying to read and prevented you from reading it, among numerous other differences between modern web ads and classic print ads.
It'd be funny if all these state governments end up having trouble getting internet.

Let's say Comcast & all the others violate net neutrality in some small ways. (I.e. A plan where you normally have 100mbps, but youtube can go faster because their servers are well-spliced with the internet backbone. That's a thing that violated net neutrality.) And then-- well hey, they're violating it. And most other businesses end up violating NN because of other optimizations to delivering internet content.

As a cynical libertarian, I love this. There's the potential for state government to lose internet access. That would be _so good_.
Lawyers are one of those costs that can be a lot, or controlled, depending on how much negotiation happens. For billion dollar acquisitions usually you will pay $1-2mm in fees in my experience. For smaller acquisitions I've seen anywhere from 100-500k. Those are very loose ballpark numbers.

Other closing costs -- usually there will be an escrow service for any holdbacks. That usually is only tens of thousands of dollars - not expensive relative to deal size.
It truly is. I wonder if we're being told the whole story though: some woman shows up at another person's door with no connection at all, but has a signed court order as their guardians? It is mentioned that the couple's daughter visited almost every day. She couldn't find a lawyer to immediately file an injunction?

EDIT: Yeah, looks like the authorities stepped in[0].

[0] https://www.reviewjournal.com/crime/grand-jury-indicts-nevad...
Can you recommend a good primer on what we know about evolution and the history of our species, and the supporting evidence?

I thought The Selfish Gene would be this, but it seemed primarily focused on more abstract/philosophical questions, like group selection vs. gene selection. I'm more interested in concrete information about what our DNA and the fossil record can credibly establish. I want to know what facts are indisputably known, and which are more speculative.
So happy we (Boston) gave them tens of millions of dollars to move here!
Startup makes labs smarter
Math is hard. Let's go shopping!
I prefer Kant.
Read up on the Bitcoin whitepaper
Thank goodness for those people that worked to uncover the diesel scandal, also thank goodness for the efforts of Tesla in changing the automobile market. These old auto manufacturers have the option to sell people nice new electric cars instead of taking the 'tobacco/lead-in-petrol' route.
I'm specifically arguing against the generalizations the parent was making in particular. "Striving to reduce rights" of US citizens is generally anti-constitutional as a concept, especially for non-lawmaking organizations.

The 4th amendment doesn't really affect any of the original crypto argument, because the search cannot be performed. Cryptography prevents the "this is the way that's acceptable" act from even starting. Note that the amendment simply says that a warrant is allowable in a bounded implementation; it doesn't demand that warrants must be executable.

For instance, if a warrant is issued to search a non-existent building it's just as moot. It doesn't require the building to be created if it's not there.
That's from Predator
those are concerns of every project , we will see if timescale is different

But is it good enough , as a product it needs to prove to me its good enough to switch. Many people dont need a specific time database. Many people have created solutions on top of their current database.

We have hadoop and other post processors that can allow us to off load old data but raise features to the user to get data in the past.

Is this better? And how much more does it cost? Oracle didnt get successful becuase people couldnt store data before them. They were successful becuase it became a need: You have a DB solution or you dont and if you dont you cant be secure in your "data assets" (Martin Fowler talks about this).

So if I dont have a Time database ... what cant I do? Who is going to not do business with me unless I have a time db? I hope you have some good enterprise friends.
The thing is, there isn't going to be any large scale nuclear exchange. For one, North Koreans don't have that many bombs. On the other side, it wouldn't take that many bombs to glass the entire country of North Korea.

During the Cold War, by contrast, the Soviet Union had approximately ~48,000 warheads.
The way to make it not tricky is to be //remote friendly// in your work culture and get the interactions externalized and committed to information storage and dissemination systems.

Make processes phased and allow for multiple inputs (maybe blinded) during each phase, followed by a digestion step. Repeat this cycle until a strong consensus is reached.
It's a private beta. What's the basis for trusting the peer nodes?
It's a cool tool. But for a really small audience. Most professional designers take care of these things first up.
Agreed. I especially enjoy the code review episodes.
Looking forward to reading the postmortem.
No I believe gRPC is a different thing. Don't know what net/rpc is.
Dutch intelligence first to alert U.S. about Russian hack of Democratic Party
Indeed, this is my biggest issue with all the market-cap numbers we keep seeing.

The market-cap is a made-up number calculated by (current_price x num_tokens). Except that current_price isn't fixed and the buying and selling will change it. You aren't selling to an infinite buyer market either, so you can't just sell everything at once to extract that value in one go.
> Infinite time horizon

I get what he's going for here, but this phrasing just sounds too TED-talk-y for me. I also don't get what they'd change as a result, but I guess that's TBD.
And there are plenty that do. What's your point?
Don't feel bad.

I made and lost 30k speculating on dumb stuff like Mazacoin and Auroracoin. I avoided looking up any numbers for a long time, but my non-tech friend asked me the other day what it would have been worth. If I had invested 20k of that in the Ethereum presale, it would be worth 30 to 40 million dollars (or would have been when the market was high).

Could kick yourself for stuff like that (I read the initial posts about Eth here on HN, figured it would be valuable, didn't know how soon it would be valuable), but the market was scammy even then. Mazacoin was supposedly going to be the first official coin of one of the Sioux reservations; that was exaggerated, didn't keep it from spiking 10x overnight.

There's nothing special about making a fortune gambling and taking money off other dummies throwing money into the hype. Regular people are getting hurt by this. For every big winner, there's some family who had a dad who mortgaged their house and lost it all. Maybe that's post hoc justification of missing out, but there's nothing to be proud of.

edit: doing the math as of today; $24k would have bought you about 80k Ether at the presale price of 2k eth per Bitcoin (about $600). 1 eth is about $1050 today, at a value of $1k that's 80 million dollars. The fortunes that people can and have made at out of this are absurd.
Except for all the cases in which things didn't turn out fine, but would have if a cellphone had existed, and that you never really heard about. (minor grammar edit)
all human beings should be allowed to record their thoughts and communicate without those thoughts being surveilled. What is so different in 2018 that the ability to think and communicate in secret is somehow a threat to law enforcement? Law enforcement has always had to work hard to crack a case. Now that computers exist, they want to have a comprehensive record of everything that's ever been uttered, retroactively play back anything that the authority deems inappropriate, and make arrests on that basis. It is fascism in a can. There could be no clearer indication that political protections are inadequate to safeguard this than the current president, who has run amok without legal consequence (to date).

I cannot understand how any thoughtful person can support anything more invasive than hard police work and a warrant... any legal case can be cracked with human tools, because no criminal operation has 100% operational security. The need to spy on the thoughts of innocence is an insane price for any extra crime fighting ability we get on top of this.
One bit of immaturity I just remembered: InfluxDB does a terrible job of telling you when you've fat-fingered a query. You can select from a series that doesn't exist or reference a tag that doesn't exist inside a 'where' clause, and InfluxDB will happily return 0 results instead of giving an error.

I've spent some time trying to figure out why I'm not getting data, and it turns out that it was because I typoed the name of the series.

I still like Influx though, warts and all.
And I pretty regularly stay, for roughly the same price, at "extended stay" hotels (where I am not staying for an extended stay) with a kitchen, albeit a small one.
On paper, yes, that's exactly what they promise. In practice, they "suspended" this last April:

https://tether.to/announcement/
Gaswagen
Here is Forbes making the point:

https://www.forbes.com/sites/timworstall/2011/06/28/gdp-for-...

GDP to market cap is worse. The net worth of a country is not it's GDP. The total wealth of the US is about ~90 trillion.

https://en.wikipedia.org/wiki/Wealth_inequality_in_the_Unite...

The estimates for total wealth, however, are really fraught and fluctuate, as does market cap in other currencies.
From the perspective I gathered through understanding a very beautiful unified theory (not my model) - this is exactly my point.
EM waves as we use it are useless for long distance communications. I even doubt that those waves will still be detectable in a different solar system as the general assumptions that our vacuum is a very homogeneous is not true for me (the underlaying dimensions are for me, but not the vaccum as we know it). I have much more effects that cause disturbances of such waves.
Inside a solar system, there are also better techniques that are more stable in propagation then our Hertz EM waves. But unfortunately, we adopted a form of Maxwell Equations that are not suitable to describe the phenomena (the original equations in quaternion math can however). Nicolas Tesla did a lot of research in this area, but it is not very well known/understood. (From the model I'm using 3 forms are derived. As far as I dug into Tesla, he worked with 1 form. The 3rd form is the interesting one but very hard to produce /detect.)
Moreover he has no response to the question of how to scale the idea of "expensive to break" into even the near future. And then he is aggrieved and asks for "proof of impossibility" never mind the more fundamental problem with that ask, it's not something his suggestion even approaches needing. It's trivially insecure. He has done nothing to suggest that the assumption that "we could do it right" holds water. And who is "we?" Even "we" is a tendentious notion.
There is no one magic bullet to deal with such a problem. Instead there are several things you can do in parallel to help. Whichever of these works for you depends on the industry and age of the company you are in.

If the company is fairly new, then bad code is kind of expected. There is a rush to get a product out the door, so shortcuts are taken. Given time for things to settle v2 will be better.

If its an established company or the code is legacy you can fix little bits as you go along. If documentation is lacking, write some - maybe even set up a wiki and bug tracking system if need be. If comments are lacking add some.

If you can demonstrate the bad code is costing the company more in man hours (and therefore money), then maybe propose a a series of refactoring projects in order to help improve the code and increase efficiency. I worked at a company that would have refactoring parties once a month with pizza and chipper. On the last Friday afternoon of the month we would review 10 random code files changed in the last month and tidy messy code, add comments, docs, unit test etc.

Suggest the company adopt some coding standards if they already haven't. Ditto code reviews and unit testing.

Of course not all companies are receptive to such changes. Some take the view that if the product works, why wasted time on frivolous extra like docs and code reviews. Sometimes when the code has been primarily the work of one person they might not take kindly to criticism - even if valid. In those cases all you can do is just do is to write your own code as best you can and not worry about what goes on around you. Bad code is a lot more common than you expect and life is easier when you accept that.
Simple economics. People will weigh the value of being able to use their phones and/or record the performance versus their want to attend.
Nice. I will be sure to only upvote you sometimes so you stay on HN a long while.
It's an interesting contrast.

Uber was much more problematic in terms of culture (at least until recently, if you're inclined to be generous) and they seem to have been more directly involved in actively thwarting laws, etc. And they've created this big gig economy workforce that is barely scraping by in most cases. On the other hand, with relatively few exceptions, existing taxi companies--and especially those built around medallion monopolies--were extremely user-friendly and generally pretty awful in a lot of places.

AirBnB, on the other hand, seems at least more reasonable as a company but has still turned largely a blind eye to its hosts evading their legal requirements in a way that's arguably much more damaging to communities than Uber.
For extra extra fun, the Hopi Nation, completely surrounded by Navajo, does not observe DST.
'Calibre'?

People without spare money are of the wrong 'calibre'?

We weren't all born with latte money to spare. A CEO, brain surgeon or astronaut might have had a shitty car and been happy for an easy $5 when they were in grad school. Calibre my ass.
Compression ignition engines are a big breakthrough–we got to try one
for certain species of geckos yes, not for any type of dragon.
Adsense, Analytics, Docs/Sheets/Slides, and Google Earth belong in the acquisitions bucket.
Culturally though, people do for the most part. Whites hangout with Whites, Indians with Indians, Chinese with Chinese, etc.. it's not racism, it's human nature.
Bicycle Riding Robot
It's all speculation. There are tons of markets out there seeing similar inflation, though the geek crowd only focuses on the cryptocurrencies.

Like all speculation, for every winner there are hundreds of losers, and hindsight is 20/20 but it's impossible to reasonably predict the future outcome.

Don't worry about it :)
Sounds like they're talking about car ownership.
I'm with you, hotels are instant to book while airbnbs you have to correspond and have this whole personal experience, no thanks. Also I can't in good conscious support them after having to buzz in a drunk airbnber at 2AM who was ringing every single apartment in my building because they lost their key.

Likewise, Cabs are much cheaper and faster to grab than Ubers in my NYC neighborhood (east village). Don't believe the hype...
gRPC uses protobuf, they are not synonymous.
Andddd still not available in the UK. Exactly as it was the last time I looked into Robinhood (probably around a year ago).
I believe copper piping is most-common, it's always the first thing building-site thieves go for!
Yeah, I think a similar video played before the start of the show, about how you paid all this money to be here, why see it through a small screen as if you were on YouTube, combined with a few people actually getting kicked out, would work wonders.

They can have a moment in the show for everyone who "needs" a picture or a brief video can take one. And just let everyone know that the whole show will be on YouTube in good quality later-- no need to take your own.
Why not both?!! (summarizing tweets occasionally)

Perhaps a resurrection of the Redis Watch newsletter is in order! Are there any existing alternatives?
I tend to agree with you, but it just seems like Steam would need a way to prevent people from abusing the system.

I don't just get to ignore laws when they conflict with my goals. I mean, that's kinda the point of laws, right?

I'm sure Steam can avail themselves of whatever legal mechanisms ozzies have for fraud in general or w/r/t returns in specific. If Steam is, in fact, obligated to honor a return with no legal recourse, even in cases that they still classify "abuse," then that is exactly the point of the statutory consumer protection. Just because they call it abuse doesn't mean the Australian people agree.

They might be able to convince the government that what Valve perceives as a weakness in the boundaries of consumer protection is, in fact, against the public interest. They're also free to leave the market.
Hi, you've posted this notion that partitioning a column store by time would yield the same result as TimescaleDB a few times, so thought we'd jump in and clear things up. We fully agree that column stores have their place, particularly if you have a massive number of metrics, and all you care are roll-ups on single column axes. There are some major differences between TimescaleDB and column stores. Namely, TimescaleDB supports a lot of features that column stores in general do not.

- Secondary Indexes.

- Transactional semantics.

- Can operate on data sets greater than available memory (doesn't have to be all in-memory unlike memSQL and some others). Time-series data is voluminous.

- A whole bunch of specialized time-based optimizations that optimize query plans when working with time-based indexes and data.

- Constraints - Including foreign keys.

- Triggers

- Joins with relational data.

- Full SQL - allowing you to use complex queries and window functions

- Compatible with data tools that use SQL - which gets you gets you the richest ecosystem of tools in the data world

- The full gamut of Postgres datatypes including JSON/B and GIS location data

- 20+ years of reliability, tested backups, live streaming replication, etc.

- Geospatial support through best-in-class PostGIS

And of course, we're only getting started :)