skysight-inc/HackerNews huggingface dataset:
There are a lot of people thinking about beneficial factors in young blood and harmful factors in old blood. Some are looking at period apheresis of blood to remove harmful factors, some are investigating transfusions, some looking at delivery of factors directly.

I don't see this area of work as a useful way forward to major impact on human aging and life span, though it will no doubt increase understanding of the way in which metabolism reacts to the causes of aging as they increase. Like much of what goes on in the research community, it is an effort to tinker with secondary and later aspects of aging. Changes in factors in the blood are not the cause of aging, they are the consequence of cellular reactions to the causes of aging. So this sort of work is changing the oil and cleaning the spark plugs in the hopes of small gains rather than repairing and replacing the failing engine parts in the hopes of large gains.

But that is somewhat beside the point. The important thing here is that organizations like the Society for the Rescue of Our Elders have come into being and are surveying the field for things they can do to impact aging, ways to accelerate the otherwise very slow progress of clinical translation in a field of research that is, on the whole, still pretty reluctant to actually make waves and public noise. Given who is involved in the Society, it will mean a lot of garbage in addition to the actually useful stuff like senolytics, but overall it is much better to have people actively trying to organize trials to gain evidence rather than not. That speeds up the process of winnowing out the useless, marginal projects and promoting the useful ones, on the basis of the results rather than debate over mechanisms.
Fascinating stuff.
Flight service resumes at SSR airport after forecast of tropical storm
Yeah, that's one of the hypotheses.
Yep, and for the millions of people who can't statistically be outliers we have to figure out how to live with being normal.

That means living with not being rich or famous or actually being particularly good at anything on a global scale.

Phelps was supported by a society that brought him burritos and clean towels and factory workers who made swimming caps and if he has stuff to teach all of us regular people about depression I think that's good to hear.
Skimmed the piece. Was there any real imsight about dealing with chronic illness?
Jeff Minter also created Tempest 3K, but as other commenters have already pointed out, it was for a very obscure system (the Nuon).
Slack ruins all my laptops from $3000+ latest Macbooks to my HP Pavillion - it eats up memory like Crazy. Using Slack for 2 years now and they still havent fixed it.
Good point. Indeed it is interesting to follow the Firefox Quantum approach (which breaks with XUL) or KDE's open source office suite, aka Calligra (https://www.calligra.org/) which is "plain C++/Qt" and thus not a sole effort to solve the cross-platform UI/object model problem such as Mozilla and StarOffice did in their time. Thanks to this, Calligra devs can probably concentrate much more on implementing features while getting a modern cross-plattform UI for free (literally: Qt is free).
Using named return variables to capture panics in Go
Japan's Biggest Bank Is Releasing Its Own Cryptocurrency in March
I wrote about creating adaptive streaming over HTTP (MPEG-DASH) using ffmpeg and mp4box before [1]. It is nice to see that ffmpeg is incorporating more and more of the same features.

Has anybody got ffmpeg to create HLS out of mp4 fragments as well? It would save some conversion time and space, since the same MP4 fragments could be used with the two different manifest files, DASH and HLS. Mp4box is not quite there yet, sadly.

[1] https://rybakov.com/blog/mpeg-dash/
'Liquid biopsy' promises early detection for cancer
What a lovely article. Was interesting and learned about the comma operator, which is really awesome.
Interesting connection to apply flow to this issue and point out drawbacks from not reckoning with the things not focused on. Mihaly Csikszentmihalyi wrote about applying flow to much more than one’s main skill, such as personal relationships and free time. The back burner should be maintained using the primary skill of achieving flow state. Sertillanges is another writer who wrote about setting the stage for focused work, and for him maintaining health in basic life areas (diet, exercise, spiritual exercise) was a given to support the main work.
Parent I responded to does not know. He is just horrified that couple would save on healthcare. If you live in system with socialized healthcare, you don't have to make these decisions.

However, if you pay out of pocket then you do have to make those decisions personally. Else you will be taken for financial ride.
> Why give up on performance?

We don't need to give up on performance, even with low-performance RISC-V chips. What we need is a new architecture which takes advantage of low-speed multicore processors. If it is possible to produce thousand-core RISC-V chips [1] then any core could be assigned a single thread - which implies that there is no need for a complex multitasking OS.

[1] Towards Thousand-Core RISC-V Shared Memory Systems (PDF)

https://riscv.org/wp-content/uploads/2016/11/Wed1000-Thousan...
I was interested in an answer to my question to understand your perspective. You won't give me an answer. That's okay, but so is my desire to set parameters on conversations that I engage in.
You do realize this is exactly what made Trump president right? Shout one thing the public wants, shout it hard and repeatedly to mask your incompetence in all the other things that are important to have a prospering nation.

The public will vote for one thing in plain sight and complain about their own choice the day after because all the other things in their life suddenly take a bad spin.

TL;DR; do not vote blindly on a single action point. Do not bewilder others to do so. Instead vote for the complete package and learn others to do so as well.
The language itself isn't coupled to LLVM outside of some underspecified details around things like unsafe and the memory model, which will eventually be better-defined.

The compiler has historically been fairly strongly tied to LLVM. This is changing for several reasons as the compiler is refactored, which should enable alternative backends like directly generating C or even plugging directly into GCC.

There is also an LLVM backend for generating C, at various levels of maintenance, that might be made to work.
Publish front end tutorials
>If that's the killer app, I wouldn't be too optimistic.

You could have said the same thing about the internet after seeing the web in Mosaic.

People are using VR Chat, and adoption alone is what makes a "killer app." Complexity and depth and such can come later, but only after the masses have cared long enough to build on the foundation.
It will be interesting to see the financial world move toward blockchain. It's a better technology in many ways, but adoption is slow in big institutions. There will be an arms race between cryptoanarchists (who want total anonymity, and can cryptographically ensure it) and governments & banks (who want total traceability, and can cryptographically ensure it).

It's hard to predict, but I expect to see a corporatization/cephalization of blockchain over the next 10 years similar to that of the internet in the early 2000s, which had also been something of a wild west.
Self-Hosted Project Management Tool – Output Time
You live in a rich environment where people can afford gopros - where I'm from(Poland) for a lot of people even the cheapest Session camera is 1/2 of your monthly salary. I've got some friends who work as C++ programmers, and for them the Black 6 is 2/5 of their salary. It's just completely unaffordable for vast majority of people, but there's plenty of Chinese knock-offs around, re-branded by local companies(Manta for example), and those sell a lot. If you go to an electronics store looking for an action cam, 95% of their stock is gopro knock offs, if you want a GoPro it's not that easy to find.
A semiotic analysis of the genetic information (2006)
pi-hole is fantastic.

Plus, you get free ad blocking for most of the native apps on your mobile devices when using wifi at home or outdoors with VPN (haven't tested the latter yet).
Jamais vu – a 1.0.0 TrustZone code execution exploit on the Nintendo Switch
Ask HN: Is the “don't roll your own crypto” culture making us crypto ignorants?
Sometimes I ask myself if this generalized crypto mono-culture is something being implanted in our brain to spare NSA money.

I would see how much effort ingelligence agencies would need to handle the proliferation of many privately developed ciphers by the open-source community.

What do you think?
"Let me get this straight… you're saying we should organize our societies along the lines of the LOBSTERS?!"

Harsh, perhaps. Honest, not so much. I found most of her ripostes a dishonest caricature of Peterson's position, or downright lies.

https://youtu.be/aMcjxSThD54?t=1331
No, the widely accepted interpretation of that law is that, if I have a coworker who wants to be called xe/xem/xyr/xyrs/xemself, I have to comply or face punishment, since not be accommodating of this can be construed as harassment. Ideologues want to dismiss everyone who is against this law as transphobic, but this is demonstrably not true, one can be accepting of the human rights of trans people while simultaneously disagreeing with the extend of protections and privileges granted to them.
I think what most people ultimately take issue with, is that this law was evidently ideologically motivated and it felt like no logical arguments could ever be discussed.
My first son was born 10 weeks too early, we lived in Denmark at the time, cost 0.

My second son was born in New York and we had good health care coverage costed us nothing.

Right now we are on Cobra and we are fine. But once thats up we will have to find something else and I worry about the cost of that plan.

One thing I have learned though is that it's normally possible to negotiate the price down quist substantially (more than 50% sometimes) especially because these days it's the hospitals themselves who need to do the collecting and they simply aren't prepared for that (patient cost sharing up 230% and deductibles up more that 60%) They just want some money.
How does Vala handle debugging info and compiler diagnostics? Do the end users have to analyze the emitted C when something goes wrong?
10.6% of Iceland's population consists of first-generation immigrants, first and second generation make up 12% of the population. By comparison the US population is 14.4% first-generation immigrant. How is that a low level of immigrants? It's every 10th person on the island.
Was fortunate enough to take Dr. Gupta's undergraduate-level version of this class over a decade ago. To this day I still remember how enjoyable and simple he was able to make this material, despite it being actually somewhat tricky. Definitely one of the best CS lecturers UIUC had to offer at the time.
Interesting read. I quite like the pipe operator as I think it would make a lot of code easier to read.

I would caution people against using some of these "features" though as writing clever code that leverages obscure techniques is NOT good for readability and maintainability.

The person who has to maintain your code will probably be able to more easily grok some boring if else statements than some weird ternary thing that leverages the comma operator.

Just because you can doesn't mean you should.
>> Whole foods has a lot of very niche specialty food. That is what they are probably scaling back on.

A lot of people go there because of those items. But hey, if they want to compete on price with Kroger more power to them.
I'm not sure if this is related but maybe egoless programming is what I am thinking about here... I felt uneasy reading the OP. I follow much of the advice myself, and I can see how it is necessary to be diplomatic when there are tensions in the team.

However, I much prefer it when people give me their raw and direct thoughts on the code. "indentation wrong", "really hard to follow this code", "why does this class exist?"; now we're two developers looking at code, and we both want it to be as neat as possible.

If I can tell that the reviewer goes out of their way to be diplomatic (e.g. by following the OP or by randomly praising code that is not broken), they're obviously worried about hurting me; and suddenly we are not managing my code, but me! Why? Am I on the brink of being fired? Did I ever overreact? Am I too attached to my source code? It also becomes impossible to tell how strongly the other side actually feels about their suggestions when everything is posed as a "what do you think" question.

It could be a cultural thing too? I'm German and American politeness often makes me paranoid because every flowery statement could be criticism in disguise.
DDD and co., part 9: Coding the read model
I hope you are not involved in public health because you are dangerously misinformed.

A major cause of flu death in otherwise healthy people is secondary bacterial infections and high quality home care would really help.

Your statement re: antibiotics is accurate re: the primary problem but not in terms of actual cause of death which is very often secondary infection.

I would choose hospital care over home care any day of the week, but if there were a serious outbreak then government paid time off for carers plus basically universal antibiotics would be a logical response.

I think you are being too directly logical and not thinking systemically.
There are many events you could have chosen, including those with mass media.

If you think the science is wrong (as I do), you might have selected Kitzmiller v. Dover Area School District. Or Ng v. Jacobs Eng'g Group, where an employee was fired for using "company equipment and facilities to proselytize for her evangelical Christian faith."

As you believe the science is essentially right, the Scopes Trial could be another comparison.

If you are for free speech, you might have selected Abrams v United States.

But since Google has no power to enforce house arrest, or levy fines, or apply other coercive power, all of these comparison are far grander than the case deserves.

Best would be to compare it to similar cases, like those described in the EEOC guidelines regarding a 'hostile workplace' at https://www.eeoc.gov/laws/types/sex.cfm . For example, it says "it is illegal to harass a woman by making offensive comments about women in general", and gives guidelines on what 'offensive' might mean.

Along with https://www.eeoc.gov/policy/docs/currentissues.html : "Unless the conduct is quite severe, a single incident or isolated incidents of offensive sexual conduct or remarks generally do not create an abusive environment. As the Court noted in Vinson, "mere utterance of an ethnic or racial epithet which engenders offensive feelings in an employee would not affect the conditions of employment to a sufficiently significant degree to violate Title VII." ... A "hostile environment" claim generally requires a showing of a pattern of offensive conduct". )

So perhaps Meritor Savings Bank v. Vinson and similar workplace-related lawsuits are the better comparison. There are quite a few.
Not mentioned in that list of downsides is that you need to at least embrace the calling conventions, threading models, and memory models that C supports, at least for the flavors you target.

> The biggest loss is that a lot of error and debug info will be relative to the C rather than your language. This means the user will be exposed to the internals.

In other words, sometimes the end user has to debug a bunch of code they didn't write. I wouldn't underestimate how much a pain this can be.

> Probably the biggest win, is that it’s almost trivial to integrate C, and potentially C++ libraries into your language.

Again, subject to adhering to threading models, etc. If you're writing a language as a hobby, this may not be a big concern, but at scale, someone will be using memcpy or memory barriers or thread-local memory somewhere. It is certainly possible to support those use cases, but I'd be careful about overstating how trivial that is.
I love it, it is like playing with Lego but with infinite blocks and for free. And you have cool modules already built on GitHUB for free again.

It's the neverending joy :)
Lossless Brownian Information Engine: convert information into mechanical work
Tricks to Strengthen Your Body Against Winter
C16 refers to the Ontario human rights commission for interpretation and policy which is a huge problem.
Front end in 2018: More consensus, less complexity
This looks pretty awesome..

I was hoping this was about the command-line tool, which is quite daunting to learn once you start getting into the filters and combining/merging multiple audio and video sources.

In a recent project I eventually had to write a script to do 2 passes of ffmpeg after spending a good day trying to figure my way through all the filter documentation to do a 5-step process in one pass..

This isn't a knock against ffmpeg, which is an amazing open source package, but it's complicated, so I'm sure this repo will be of great help to many.
Why is that? Why can't you keep an open mind, traverse multiple sources and draw your own conclusions? Think of it as a diversified portfolio. I'm not asking for more time, just that it we spread out.

Without that, we get the barely binary system that we have. The MSM can be lazy and non-journalistic because no one bothers to notice. No one cares.
My question is specifically about the phrase and a lot more say in what kind of policy I could get to better accommodate the needs of my family.

I'm wondering where the other poster thinks they would save money vs insurance that covers things like child birth, hospitalization, emergency room visits, etc.
Or an MVP.
2-year-olds can use simple apps on tablet computers.

I don't recall any desktop app from the 90s whose features would be discoverable by even a 3-year-old.
How is any case comparable to that of a millionaire Olympics winner?

He has all the possibilities in the world to cure his depression, including long vacations in any place of the world.
not even close. the average gap is closer to log(n).
Linear regression by hand
20 Deadly Mistakes That Kill Startups (According to Experts)
This seems like a prologue for something interesting, but where the actual mass? It ends very abruptly.
Too bad, i'de read more of there was any.
When I wrote "old fashioned", I refered primarily to the look-and-feel but also the status of the code base (+20 years), the fact they don't use a widespread UI toolkit but rolled their own, etc.
Organizations Are Not Families, Part 1
That I don't believe that many of those experts spreading this message are paid of by the NSA or similar orgs.

And that being crypto-ignorant is not connected to only using known tools for real systems. In many cases, self-made crypto is done from an uninformed perspective, which is why it often is so bad. Just as using well-known crypto doesn't mean you haven't spent the time trying to understand why it is recommended and how it works internally, why alternatives are bad, or having made your own crypto and learned from that.
>In summary this is the very basic idea behind a video: a series of pictures / frames running at a given rate.

>Therefore we need to introduce some logic to play each frame smoothly. For that matter, each frame has a presentation timestamp (PTS) which is an increasing number factored in a timebase that is a rational number (where the denominator is know as timescale) divisible by the frame rate (fps).

Constant framerate is a very dangerous assumption to make. It's true for video recorded by professional cameras, but if you check video recorded by most mobile phones you notice that it's wrong.
> I don't think there's a reason the name GoPro couldn't be put on a variety of high end outdoor gear--surfboards, snowboards, etc.

GoPro is kept alive by the huge margins they can ask for on the basis of being the recognized inventor of the action cam market. The company knows absolutely nothing about operating on tighter margins.

The markets for "surfboards, snowboards etc" are even more brand aware, but that cuts both ways: GoPro would be seen as the outside giant trying to buy their way in.
where log(n) is the natural logarithm of n

https://en.wikipedia.org/wiki/Prime_number_theorem
Sometimes its a good idea to use a faster probable prime test when searching, and then use a slower test to verify the result. As has been done here.
They'd spend much less, because most private efforts would fail. For a real world example, consider how many crypto locker malware examples have been found broken in a way you can recover your files without paying. These is a proliferation of privately developed apps just using standard ciphers, not even creating new ones. They mostly fail at using the most basic form of symmetric encryption.
This doesn't seem particularly courageous, plucky, fearless, valiant, valorous, intrepid, heroic, lionhearted, manful, macho, bold, daring, daredevil, adventurous, or audacious.
With UBI, you have two important new options:

- You can move away from expensive locale to a cheapest one.

- You can find supplemental income: do something with your hands, provide services, etc. You have all day to do that. It shouldn't be that your time is worthless and nobody is willing to pay anything for it.

- You can pool with other people to form a community, save on bulk.

Three actually.
Its surprising how effective trash-print still is, even today. In Europe, its a very significant form of propaganda; the free daily trash-mag at the train station, literally provided free for the taking at the exclusivity of all other rags, is nought but fodder for mind control.

Its a principle means of influencing the minds of commuters; and it works so well, because nobody ever thinks "this is free, therefore its good", but rather "this is free, so everyone has it, so I must too.."
Alternatives to Acceptance Tests
> I want the latter to continue to be a practical option, for me, my children, and the world.

And I want world peace and a free Mercedes.
The case against ORMS
Aren't the VAT requirements going in the exactly opposite direction then? Is it good for privacy that a bunch of different - and of questionable security - tax offices have to know who and where you were exactly when you purchased your sex toys?

C'mon man the cookie thing is a silly PR gesture, with measurable economic cost in the time it takes to dismiss all those dialogs in your tiny phone screen. It has done nothing, absolutely nada measurable in attitudes towards tracking.
Do you load the hosts directly as a remote pointing to the raw file? Gas Mask is complaining about "unknown content" when I try that.
We should only use language features which spark joy.
One thing in flamewars is arguing about performance. Another one (which is more related to the OP) is readability and simplicity. If you compare a simple GUI program written in Vala/GTK+ with one written in C++/Qt, without doubt the Vala version is easier to read for the uneducated. Of course, things may reverse if the problem is complex and C++'s OOP or the moc stands out compared to GLib ones.
I'm running on Wayland at this moment (Gnome 3 on Fedora), and just tested on the terminal. It has two: I can copy something with Ctrl-Shift-C, then select something else, then paste with Ctrl-Shift-V, then paste with middle-click; the selection didn't override what I had copied, and middle-click pasted what was selected.

So you still have two, at least with Gnome 3 on Wayland.
Spaceradar supports this feature https://github.com/zz85/space-radar#reading-from-a-file-