skysight-inc/HackerNews huggingface dataset:
Ask HN: Did Ping GPS close up shop?
Ping GPS started as a successful crowdfunding project and sold a massive amount of units, according to its website.

However purchasing is disabled for a long time now, redirecting to a waiting list, and none of its social branches seem to be active.

Is the project still alive? If not, what is the best alternative for a good durable GPS tracker?
>Targeted chemotherapy consists of drugs that are meant to specifically kill cancer cells and not healthy cells.

Putting immunotherapies (like nivolumab) under this category I think will only confuse the reader about the state (and direction) of oncology.

Nivolumab doesn't target cancer cells, it blocks an inhibitory receptor on T-cells, which then kill cancer cells more readily. It's been approved for a wide range of cancer types since it's really a treatment of the immune system:

https://www.drugs.com/history/opdivo.html

Approvals to date: melanoma, lung cancer, kidney cancer, hodgkin lymphoma, head and neck cancer, bladder cancer, MSI-H colorectal cancer.

The distinction between targeted therapies and immunotherapies is very important since, aside from different mechanism, they also tend to have very different trajectories of relapse/resistance. Any metastatic cancer is essentially guaranteed to become resistant to a targeted therapy within 6-18 months. Drugs like nivolumab, on the other hand, offer a minority of patients (10-40% depending on the cancer) a chance at durable responses (cancers either cured or prevented from spreading by immune surveillance).
Actually, I once worked with someone who adamantly refused to go through a door being held for her.
I can understand why women wouldn’t want to be engineers because I can understand why most men also don’t want to be engineers. Engineers are a small subset of the total population and it’s difficulty to say whether we have optimized for either sex but trying to make a one-size-fits all environment seems sub optimal if the goal is to increase total numbers of CS professionals. CS programs should be as popular as ever for males, but it does seem like they could be more popular for females if there were environmental adjustments. Rather than trying to adjust the entire environment (which may discourage men from entering) to one-size-fits-all, I think it makes more sense for some schools to specialize in attracting and training women and in turn those companies that provide meaningful opportunities and environment that are important to women can also more easily find a larger pool of talent.
So maybe he is one of those "I'm so passionate about my job, I would literally do it for free" kind of guys?

I do hear that "bullshit" everyday from countless people and think it's refreshing if people would share what they would truly do if they had the freedom to choose.
One of the very best programmers I've ever worked with is female. She said almost this exact thing to me, basically: "On the one hand it's awesome that I can have my pick of any job in the business, on the other hand it sucks that I don't know if I'm just a statistic for them."
Ask HN: A stackexchange site vs. a subreddit, which do you prefer to use?
Example: bitcoin.stackexchange.com vs /r/bitcoin
Yea that's what I am doing now, but don't have the push notifications to make it useful.

I am not required to access my work emails outside of my core hours, but it comes in handy if I could get notified of a new email directly to me (I get 100+ emails a day with maybe 10 requiring me to do something).

I like to be prepared knowing what I need Todo before I come into my office the next morning.
Read a bunch that has piled up (amazing books from writers I admire).

Meet up with friends that I mean to meet for a long time, and somehow don't manage to.

Maybe do some day trips to places nearby but still off my beaten track...
> What else is there?

Immunotherapy?
I am happy to help with either task if you require gratis. Happy to provide references upon request.
More Things I Wish I’d Known About Bash
I have already opened an issue for this. However, it doesn't resolve the underlying and rather harder to fix problem of different language-specific package managers embedding copies of C and C++ libraries which can end up in a horrible incompatible mess. It's not specific to pip/pypy, it also applies to Java jars with embedded libraries and other systems which also embed.

Sometimes, this embedded copy can be more up to date than the system copy, but the convenience of embedding is often outweighed by the binary compatibility problems and being neglected and out of date.
If it were a month of free time to work on anything I wanted, I'd spend the time working on learning various new technologies that I really haven't had the time to get started on.

If it were a month where I truly didn't have to worry any damn thing, I'd pack my luggage, jump on the Harley, turn off the GPS, pick a direction, and just go. No particular destination, other than back here in 30 days..

I'd ride until I felt like stopping, find some random, relatively small town, and spend a few days there. Check out the little hole-in-the-wall dive bars, hang out with the locals, and, after a few days, jump back on the bike and pick another direction.

I've done this on a smaller scale, but never for a whole month. It's incredibly relaxing and stress free and a great way to spend time. You can meet some really cool people from all walks of life, too.
It is definitely not encryption. I believe it initially came from non-interactive zero knowledge protocols. See for example Schnorr signatures: https://cryptologie.net/article/193/schnorrs-signature-and-n...
I think the author chose a more efficient table-driven approach, due to the extra 0 in your 0-x expression.
Yes, sorry, the search space.
4 Things I Learned as a Junior Engineer
Focusing only on one gender will take your attention away from the other. You will be automatically reducing your pool of talent just to make some numbers look good.

So no, you will not be hiring the best talent that way since it can be on both sides and you won't know which one.
This sort of "assisted multi-ender" solution is a good alternative to a pure VoIP call, and elsewhere in the thread I posted links to more of this kind of remote recording solution.

The main problem with them is that they put more of an onus on the interviewee, which often isn't an option with high-value guests.
Excellent, I'm happy (and feel validated) that this exists.

As this would replace Skype (or whatever conferencing tool you're using), it's not really an additional dependency, is it?
Amazon's First automated brick-and-mortar Store opens on Monday
There is at least one [0], but I'm frankly not sure where you can buy it.

[0] https://www.asus.com/Graphics-Cards/MINING-P106-6G/
And my favorite: is lab meat vegetarian? is it vegan? Its certainly not cut from some animal, and nothing got killed to obtain it.
>industry stuffed with the finest minds

LOL. I worked in pharma/oncology. There are a lot of very smart people, but no risk takers and the smartest people I was schooled with do not work in life sciences research. Research, and by extension pharma, does NOT pay very well compared to most industries. If you are literally 'brilliant' it is a really terrible ROI for you. Additionally, if you are of the type that likes to take moonshots and think outside the box, pharma is not for you (though research in some other areas may be more fitting).

For some reason, every other industry talks about how they need to pay well to attract the best talent. Biotech/pharma/life science researchers talk about how terrible someone must be as a researcher if they care at all about money. It's quite frankly, disgusting.
So, a lot of people are annoyed by Wolfram, but this is relevant as I think that's something that Wolfram does in his free time: http://blog.wolfram.com/2007/09/11/my-hobby-hunting-for-our-...
wasd for movement versus f for picking up things is very hard to use.
Excellent! That solves the distribution problem, due to the size of the release. Nobody will notice anything off, in enterprise deployments.
> (I'd quote Office Space here if I could remember exactly what Peter said)

"... two chicks at the same time, man."

No, wait, that was Lawrence.
Uber ignores security bug that makes its two-factor authentication useless
Got a link to the ones you are invested in that are down?
While I'm sure this won't be what you want or care about, FWIW they do offer export into plaintext that could easily be massaged into any form you'd like (I'm sure it'd take at most a line or two of lisp to get it into org-mode) and can do so daily to dropbox.
For me it's not about leaving hungry, but more about having an actual taste of the food you're eating. For example I've eaten at 42 grams which was a fantastic 2-star in Chicago but I can't really remember any dish as they were just a few bites each. On the other hand Anglo in London is still a tasting menu but each dish is larger which let you appreciate what you're eating more.
> medical profession's record of responding promptly and appropriately to information showing that it needs to change its methods has never been great.

Why do you think that? Medicine is one of the most data-driven industries out there, and usually very promptly responds to new therapies, etc. Particularly for cancer.

I'm not sure what you're thinking of with regards to this.
If the rotation needs no meaning, what stretches the rope then?
> or my favorite is to export to latex+pdf, because everyone knows latex makes the most beautiful documents.

Hah, my observation from early days of using org-mode: LaTeX makes the most beautiful documents, but writing tables in them absolutely sucks. OTOH, org-mode has the most productive interface to plaintext tables that I've ever seen. When I was working on my BSc thesis, I would make tables in org-mode, and then export them as LaTeX to paste into the thesis code.
I suspect there are a lot of current hiring practices in tech that are going to be ruled illegal over time. I know first hand the university recruiting policy of at least one major tech company is specifically not to recruit anyone who is male or white, as they want to use recruiting to change the companies racial and gender make up.

This is very similar to redlining and other implicitly discriminatory practices in the past, and the longer it goes on the more likely I suspect it will end up in court.
I would search for nice enumerations of graphs, hash functions, types and functions. I doubt I would make any progress in a month or perhaps ever.

1. Find a nice numbering system for graphs. (Rooted trees already have a nice numbering system called Matula numbers. I rediscovered this independently but haven’t made any progress on graphs.)

2. I want to label every possible hash function with an integer.

3. I want to label every possible type(that can be expressed in a programming language) with an integer.

4. I want to label every possible function that can be expressed in a programming language with an integer. This might be somewhat related to #2 and #3.

I don’t care about arbitrary mappings to integers. The mapping has to be “nice”, preserving some of the properties of the underlying system it is mapping. It needs to be one to one, and cover every possible element. I don’t know how to decribe it in general, but I get a good feeling when I see it. For example, I would be surprised if a nicer mapping between integers and trees than Matula numbers was found.
It's possible that "public" could also mean areas controlled by the state [1], in contrast to the "private sector".

[1] https://en.wikipedia.org/wiki/Public_sector
Nano cranes form molecular assembly line
The article sounds pretty negative, but if you look at 5 year survival rates for cancer you see slow but steady progress: https://pancreaticcanceraction.org/wp-content/uploads/2012/1...
Is there any sort of analogue for this with Android devices?
As far as I understand it, the Higgs field isn’t resistance to motion but rather resistance to acceleration.
I'd do a 10-day meditation retreat, and spend the other 20 hanging out with people I care about.
It is whatever the marketing department says it is.
> (Normally we associate decentralization with freedom; but consolidating authority in a small number of people rather than a bureaucratic process can make it easier to get things done quickly and iterate.)

I would hardly call 'bureaucratic process' decentralization.
> Animal farming is such a historical constant, I wonder what the unintended consequences of artificial meat are?

I know what you mean, but animal farming at the scale we currently do is not a historical constant. The unintended consequences of having 7B humans eat meat every day is a much bigger concern that not eating real meat every day.

Our current meat consumption accelerates global warming, drives wild inefficiencies in the market, and is a hell for the animals themselves. (Edit: Also represents disease vectors in humans, see shared farm resources and things like e. coli).

We need to move to lab meat to avoid the distaster that eating meat is bringing.
Perhaps people using Go, Elixir, Rust, or Kotlin to build something in a startup are expecting to make money selling the skills they gained building it rather than expecting to make money from the software they build.
The purpose of the question is to find the winner of the "I conform to the hive mind opinion of cool recreational activities better than the rest of you".

That not a leisure activity I participate in, or I already do things the hive mind feels is cool, is breaking the rules of the primate dominance game while being possibly good true answers. We're supposed to be fighting over if urban bicycling is cooler to the hive mind than homeless shelter volunteering, not pointing out its a ridiculous question for real life or mentioning there's no real reason why anything listed so far would require a month off. Its supposed to be more important that going to hipster bars is better for the hive mind, than pointing out we don't need a month off to go to the hipster bar.
My employer at least offered an incentive to BYOD. You supply your own phone and plan, and they cover a portion of your carrier bill (you have to supply your invoices to prove you still pay for the plan).
In my experience, the only mutually interesting topic is for them to spend time with their parent. If whatever you're doing is interesting to them and you spend time with them doing it, they'll remember it for the rest of their lives.

I helped one of my sons learn some basic electronics and he showed a lot of skill with it, but he soon lost interest when I tried to turn it over to him to explore. He didn't seem interested in pursuing the topic as much as spend time with me. Nowadays it's mostly talking about the software projects he's implementing and how best to architect or design his code. He gets annoyed when I become too pedantic, so mostly it's asking questions and validating (and guiding) his choices.

I've had a challenge doing activities with my oldest, as our interests hardly match up, and I wasn't able to keep the interest (I'm stubborn and self-centered). Mostly I have to listen--I'm not sure whether he enjoys me listening, but he keeps doing it when the opportunity presents itself.

My youngest--I'm at a loss. He's high-functioning autistic and plays games most of the time. He's smart and witty, so he enjoys the nuances of conversation and actually doing things with the family. He often doesn't care what we're doing, just that we're doing it together.

We do some activities (plays, musical performances, etc.) as a family (most of the time minus the eldest, as he works, etc.), and they remember and appreciate and are fond of those times when they think on them. It may not be that they were necessarily interested in them, but the fact we enjoyed the time together is what counts.

Which is to say that trying to find a mutually interesting topic is futile--they all have their distinct interests and you can't change that. But what you can do is spend time with them, pursuing their interests. It takes a ton of energy and effort, but they will appreciate it and hopefully take the same habits into their own families.
There's nothing particularly "radical" about it; if you weight everyone's utility equally when you design, e.g. a city, then the result is one that is definitionally egalitarian. And that is precisely what it means for governments to, as you say, "focus on the preferences of the populations they actually serve." Egalitarianism is only "radical" in the sense that, in most real contexts, some the desires of some subset of people are considered more important- for instance, the people who can pay more, or are a more effective voter bloc.

Not that I think the above is the decisive factor against wider adoption of public transportation. The bigger issue is an activation energy problem- public transit is only bearable and useful when a substantial portion of public funds are allocated to them, but the bulk of the public isn't currently inclined to have that happen since they don't presently use the (unbearable and useless) public transit option. Cars are a fairly vicious local maxima.
The premise of this blog post is flawed. Despite the madness of the pharmaceutical industry, we are currently experiencing a revolutionary improvement in treatment.

Essentially nothing interesting, from the patient's perspective, happened between the time that effective chemotherapy combinations were formulated (60s & 70s) and roughly ten years ago.

More recently, however, there have a surge of approvals in immunotherapy which have turned death sentence diagnoses (e.g. metastatic melanoma) into potentially survivable diseases. The 2 year survival rate for stage IV melanoma has increased from ~5-8% to 20-40%. The tools used to achieve this increase in survival are broadly applicable to other cancers and have been achieving gains in survival for lung cancer, bladder cancer, &c. More importantly, immunotherapy research is just getting started and there are lots of promising approaches (personalized vaccines, engineered T-cells, oncolytic viruses, more interesting routes of immune modulation). Many of these approaches seem to synergize. So, treatment has improved dramatically for many indications and looks like it will continue improving. There are some cancers which a patient is still unlikely to survive (pancreatic, GBM), but the industry's output of useful drugs is definitely not stagnant.

Now, the pricing of those drugs once approved is a whole different problem...
> Not sure why you're being downvoted.

Thanks, I was also confused, but according to some weird social customs enforced on HN, I cannot sincerely ask that question. On the other hand, I am not sure about the upvotes either.

I actually didn't mean to develop some new physics theory, I just wanted to play a mathematical game (like Game of Life, for example), which would alter its own space/geometry. And this seemed as a good place to mention it, and get some feedback if somebody was aware of something similar. Because I found it quite nontrivial (to make it work "decently", in a vague sense), despite my lack of ambitions to explain physics.

CDT looks interesting, but it's not quite what I had in mind.
I am not from Greece, so can't comment, but I agree with you and bet it's happening.

Definitely has been happening here as long as I can remember.

People pickup cartons coming back from US trips and resell them,, you can get it at less than half price locally. Cartons can be had for 30-40$ usd at duty free.
I have coworkers who travel 90%, they always bring back cartons and charge $20 markup.

Bringing cartons across from another province as they have less taxes.

Buying from the "native reserves" as it's tax free.

Buy from Asian convenience store, cause they are importing illegally at a lower cost.

Heck, not sure how easy u can pass customs nowadays, but you could buy cartons online from europe 5-10 years ago with ease illegally.

There's many options.

Smoking is a convenient crutch for people addicted, it's crazy that something that can make you feel like shit, but can also temporarily make you feel better.
(Mindset of a smoker... I could chain smoke, feel like crap. My next thought is, maybe I should have another one).

If anyone wants to quit, I suggest the following as mandatory Reading:
Alan Carr: easy way quit smoking (many iterations on title).

This is a magnificent book that has helped many people I know, including myself.

Helps you understand the addiction, the hold it has over you (which is mostlt mental), and helps put you in the right mind frame to quit.
Hacking is illegal in many jurisdictions.
Without a doubt....travel. Domestically, internationally, secluded nature, popular tourist places, all of it.

OK, I might need a year instead of a month.
The difference between liberalism and centrism
These exist.

What doesn't, and what I'd pay nontrivial (but not vMix Call) money for, is a tool that separated out individual audio and video streams into separate NDI streams for video mixing and composition.
I wouldn't say the first two are redundant. Trees are directed graphs where each node has at most one parent. Most build systems assume DAGs though, hence the second bullet point.
I'm not from the US, but I've had sarcastic (but not acerbic) comments from people who didn't know I hold it for everyone. Sometimes people will judge prematurely, it's not that surprising.
This article seems to me like a prime example of part of why these communities have these sorts of problems. People outside the communities look in with an attitude like "look at this poor people, it's such a shame that they have to live like this" and imply that a lot of the negatives are enabled by their culture, beliefs and how they live their lives.

That kind of thinking is exactly why these sorts of communities become so closed to outsiders. When communities are more closed they must rely more on each other internally which means they must work harder to keep the peace and can't challenge abuses of power within their community. That paves the way for more abuse. More abuse paves the way for more contempt from outsiders. If your ancestors were all arrested by the state police for living the way they believed they should live and outsiders generally looked down on you you wouldn't exactly be in a hurry to rock the boat by calling attention to the community's problems either.

What a wonderful feedback loop it is. Society really sucks at not isolating groups with non-mainstream belief structures.

It's nice to see that this particular group mostly broke its way out of the downward spiral before it got too bad.
Ask HN: What IoT development boards are you using?
We are interested in writing a series of blog posts comparing how existing Fog Computing frameworks play with various IoT development boards. Naturally, we want to learn as much as we can and make it useful to the broader community. Thus we're wondering:

What devices are you using? What boards would you like to see evaluated? What type of applications are you writing? And what is the most time- or resource-consuming function within your applications?
EDUCATIEPAKKET OVER VERSLAVING JONGEREN MET LVB UITGEBREID
Show HN: .colors() – A color picker for people who live in their text editor
I’m not the parent commenter but I recently spent almost a month in Nepal. Most of it was trekking in the Annapurna region. There are “teahouses” along all the trekking routes (some areas have more than others), which are mostly very basic but very cheap. I wasn’t alone but I met many people who were. It’s easy to befriend other people on the same route and stick together for awhile.

Aside from trekking I spent a few days in Pokhara and Kathmandu (Thamel), but much preferred the mountains to the cities.
What is lambda?
I think that's what roll20 uses for it's video and it leads to constant "Oh I can't see you but I can see everyone else" and just constant fiddling to reconnect people.