skysight-inc/HackerNews huggingface dataset:
I'm trying to fathom your point. Regardless of how much rent or mortgages cost, do you think it's acceptable or fair for individuals with chronic illnesses to bear the cost of a treatment which would cost them more than their rent (i.e. an additional cost which healthy people wouldn't have to pay?). That sounds like a pretty bad deal if you ask me - not only would one have to deal with a chronic disease, one would also have to budget for a (very considerable) additional expenditure which healthy individuals wouldn't have. At the end of the day, that is what makes the price of Humira unfair and immoral - its ability to severely financially disadvantage its patients (by being priced disproportionately compared to the cost of R&D / production).

Now, if you're talking about spreading the cost of all medical care across the entirety of the working-age population (essentially, national insurance) - that's a more sensible proposition. In fact, that's (broadly speaking, of course) what the NHS does in the UK - and the system works quite well.
Fat isn't bad per se. Excessive fat consumption however is as are saturated fats.

Peanuts mostly contain unsaturated fats. Peanut butter though might contain all sorts of other ingredients that are rich in saturated fats (like some plant oils).

The problem with salt is that in general Western diets already tend to use too much salt and too much salt can lead to an increase in blood pressure, which ultimately if untreated can lead to heart attacks and strokes.
Your comparison is hugely unfair. The accounting nonsense for universities "paying" themselves for a PhD student's tuition is ridiculous but it's not classified as charity.
Avocado is King. I have it with everything I eat these days. They are a bit expensive (but 4 for $5 at whole foods isn't too bad) and they ripen quickly but they are an amazing source of fat and are very versatile.
Typo in title: Canery -> Canary
Is there a way to "recognize" this? For example why the blue blobs and not the green ones?
https://www.mims.co.uk/drugs/skin/psoriasis-seborrhoea-ichth...

40mg/0.8ml soln for inj in vial (for paediatric use), 2=£704.28.
40mg/0.4ml soln for inj in pre-filled syringe or pre-filled pen, 2=£704.28.
As far as I understand Wechat pay is more or less PayPal. So no crypto anything.
Show HN: AreYouHappyToday.com – Microblogging to track happiness
I fail to see why this is valuable in any way. Why would this raise even a million, let alone half a billion?
I can't speak for the US, but I've been told by the clinical specialists at my local hospital that Humira cost £400+ per pen (this was back in 2015). I don't think that AbbVie can offset any of that price as a charitable donation, so I guess that price must be what they actually charge.
It really depends on what is between them, which doesn’t appear to be much.
That sounds like heaven.

The constant distraction environment of cubicles severely hampers my productivity. I work from home as often as possible, but even then I'm no longer accustomed to being able to focus on one thing for so long that I feel like I'm becoming more ADD.

People complain about the social impacts of social media etc... I wonder if anyone has tried to identify/quantify the impact of cubicles/shared workspaces.
I tried IF, but I couldn't find a schedule that worked. I work out with high intensity at 5am. So I want to start eating then to maximize nutrient intake. This made "lunch" at 9am and "dinner" at noon. I'd find myself lethargic for the morning workout.
Becaude you can't observe directly how much every person really values the assert, only the market-clearing price. No serious economist/trader thinks that 5% of the supply can be bought or sold for 5% of the market cap.

This is exactly the same whether the assets are commodities, cryptocurrency or equity yet we still talk about market cap as a useful proxy.
Can you propose another way of financing the cost of drug discovery, research and testing for safety? The current system works reasonably well but if all you’ve got is outrage I would prefer at least outrage and a plan.
Sounds like a false dichotomy.
I'm curious about your viewpoint on the Arab Spring. For me, the only role of technology in that incident was that it opened up a window into many of the issues and various conflicts that were often ignored by the various theocratic / dictatorial rulers there. Technology may have made communication a bit easier but it was not the root cause.

Most governments have not resolved these issues and conflicts at all, they have merely suppressed them (the recent Iranian protest flare ups show that). So, if anything, I see the governments in these regions as the ones being naive or worse.

In the mean time, the country that launched the Arab Spring (Tunisia) seems to have become better off for it as a result -- it was the only one that actually made major structural changes to their government in response.

(I do agree that one cannot simply throw technology at these sorts of problems and expect magical solutions to come out of thin air.)
I am pretty sure this is quite an unpopular opinion, but I think that the biggest issue we have in computer security is culture.

Information security breaches are not victimless crimes. The ubiquity of massive security failures shows that they are not rare occurrences. I believe that this symptomizes a failure of our culture, related to an inability to integrate information technology into the proper context within our society.

Sure, we need to be aware of exploit patterns so that we can make structural improvements, but we don't need to become jolly experts in them. We should stop glorifying cyber-criminals.
That’s clearly different. Same question could be asked for any banking app.
Start everyday as a producer, not a consumer.

https://lifehacker.com/5887345/start-every-day-as-a-producer...
I would agree with this, but it isn't even just straight ads. Think about something like Netflix - the $10 a month subscription is nothing to the rich person, so if they don't use it or use it for one or two shows they don't care. To the poor person they need to use it to justify the expenditure. So essentially they are incentivized to consume more, in a very indirect way.
Ketamine is being used by quite a few doctors to treat depression. There are actual "Ketamine clinics" that specialize in it. The big guys are catching on to the fact that is works, and are devising analogues: http://adisinsight.springer.com/drugs/800037644
Isn’t Apple only seeking a cut of sales of digital goods? You can sell physical merchandise like a real book, but you can’t sell an ebook without cutting them in.
> You might be a bit careful with criticizing the US on Hacker News, I have been permanently banned for similar remarks.

People criticize the US without problem all the time on HN; if you have been banned, it wasn't because you were criticizing the US (you may have been critical of the US in the comment that provoked the ban, but that wasn't the feature of the comment that provoked it.)
Maybe an expert will chime in here, but I recall learning that several concepts in ML are derived from or in parallel to the BIC. Many use feature AIC/BIC measures for feature selection.

On a separate note, AIC/BIC are prevalent in linear regression models because they are extremely well-behaved in comparison to some other models. This has generated enormous amounts of field-specific experimental literature. For instance, economists can form expectations for AIC/BIC measurements dependent on the study-type.

Additionally, we already have some decent tools for regularization (albeit model-dependent ones). Counting the nodes of a NN to establish an AIC may not lead to a proper understanding of the free parameters.

This wasn't meant to be an apologists take on why I'm not using AIC/BIC for model selection. If we're talking about "deep learning", then it's definitely a worthwhile goal to examine how to optimize network topologies. The link below mentions using reinforcement learning to learn architecture.

https://research.googleblog.com/2017/05/using-machine-learni...
What is preventing every app/service to launch their own crypto currency? It looks like in these times it is in their own interest to launch their own crypto currency than adopting an existing one as they stand to make billions. In that scenario do we say bitcoin and their ilk is failing or succeeding?
Dogecoin reaching a certain market cap shouldn't move the needle on that view one way or another, IMO.

(Personally I believe most cryptocurrencies represent a bubble, doubly so for Ether tokens. Not Doge though, that's going to the moon)
The story behind AYHT is that I was at a job that I knew I wasn't delighted at, but I wasn't really sure how long I had been unhappy or what exactly I wanted.

So after burning out of that, I built AYHT to help better track my happiness by the day to find patterns and how to help myself improve.

Mostly it is nice to get a message every day that forces me to reflect on the day and whether I was happy. It helps me appreciate the happy ones and learn from the bad ones.
TIOBE Index for January 2018
I had some free time on Friday and I was perusing https://coinmarketcap.com/
And all one has to do is look at the entire list all at one glance and you start to understand what a complete sham cryptocurrencies really are. There's three different kinds of Bitcoin on there, untold versions of Ethereum or derivatives of it, and yet no emergent use cases for blockchain or any of it. Despite all that, the bottom line alleges a nearly billion dollar market cap. You don't have to be a SpaceX engineer to figure out that something isn't right about all of it.
Jeffree Star Liquid Lip Gloss Matte Lipstick
> If every large corporate publisher on YouTube is suddenly having takedown claims filed against them, the system isn't going to stay the same for long.

That's wishful thinking, they'll just be whitelisted.
I love the way telescopes are named.

Can't wait for the "JFCTABT".
I am a happy user of Telegram but I don't think re-inventing ethereum with a small team of developers is a great idea. But then again, using existing tech gives you fewer opportunities for cash grabs...
Startup Practice Fusion Acquired for $100M
Vali Admin 2.0 is here, It's based on Bootstrap 4 with lot's of improvements
On the plus side, they are always short of Class C personnel if you don't mind.
I'm not well versed in all of this, I suspect it comes down to Bombardier being able to do this due to (allegedly illegal) government subsidies rather than being about the specific act itself.

http://fortune.com/2017/04/28/boeing-bombadier-anti-dumping-...
The AITO Dahl-Nygaard Prize Winners for 2018: Lars Bak and Guoqing Harry Xu
I don’t know if I have IBS, but I’ve noticed that lately if I push it too much with spicy foods I’m being punished in the form of unusually unpleasant and urgent BMs later. This is particularly annoying as I really, really like spicy food.

I started doing intense (for me) cardio every morning and without significant diet changes I’m already seeing the symptoms disappear. I sort of came to the same conclusion the article did from personal experience. I wish the study did more frequent samples so we could see how long it took for the changes to happen as I fully recognize that my own experience could be coincidental.
I suspect that once you get big enough, Apple is reluctant to touch you. Remember, Uber broken Apple's app rules, and were not banned, merely threatened[1]. If Apple removes the app, then who will people blame? The app or Apple? I suspect Telegram might be betting on that.

[1] https://www.usatoday.com/story/tech/news/2017/04/24/ubers-ka...
How do most people eat peanut butter? I like it spread on oatcakes - it's just ground peanuts, so it's like eating a handful of unsalted, unsweetened nuts.

USAmericans have a confection confusingly also called "peanut butter" that is high in sugar and salt, sadly most UK supermarkets now only stock the confection and not the nut-butter.
Nothing is preventing them. So expect everyone to do it.
I wonder what the author would think of today's Lisps, or languages like Haskell and Prolog that embrace non-sequential execution, allow you to freely define infix operators, and have a where syntax.
Been watching SRL performances since the 80's... Went to one in the early 90's and feared for my life. Great fun!
Na alcohol- en drugstest: vermoeidheidsmeter
Blockchain, VR, Bitcoin, AI are the buzzwords that bring you $$$. Businesses will throw money at you just for using AI/ML, blockchain, even if these use cases can be solved with a few if/else or fuzzy logic or distributed NoSQL database.
The overall trend in aviation is point-to-point routes and
frequent flights on smaller planes.

Somebody tell Delta. I'm sick of having to connect through Atlanta.
Kik has their own crypto called Kin

A lot lot lot of crypto projects use Telegram for their official chat lines.
I guess I'll take the ferry next time ;) See https://www.youtube.com/watch?v=73X6pur0rEk for more context.
Telegram still concedes to Apple.

You cant join Telegram chats marked as NSFW on iOS devices.
One thing I find odd about the index is that perl is still so high up. I've only once encountered it in a business and even then it was on the way out.

I do mostly web dev so I might have been working in the wrong places, but it's still an interesting observation for me.
Nitpick: you meant & for a bitwise AND, of course.
Integrating cryptocurrency within an easy to use chat environment has added value. Gitlab and Github have chatops, irc had chatops for ages, there were bots for twitter... chatops for payment solutions/providers/oracles is just automation. 'Ok Google, please pay HN 1 Gbyte for the inspiration.'

See for a good example how Byteball is doing this in their Android client, encrypted chat inside their wallet, chat with bots and oracles and chat with other people to send 'MBytes' to their wallet or using e-mail with a 'claim' link. I paid my lunch that way to colleagues (who are now stuck with MBytes to play with).

To get around the Apple walled garden you could even make gateway GBYTE/NEO/XBT bots for Discord, Matrix/Riot or IRC.

https://medium.com/byteball/sending-cryptocurrency-to-email-...
Yes, exactly. Click-throughs are great and easily measurable, but showing a product name/image in the context of a user seeking content has value in itself.
I updated markers as you suggested, thanks again
http://www.paulox.net/2017/12/22/full-text-search-in-django-...
Zero Power IoT Electronics
Read the findings from [1] - it appears that in a very considerable number of cases, there's actually a disconnect between the cost to research, develop, and produce a drug - and the price that's charged to customers (or insurance). The conclusion is that the price is mostly determined by "what the market will bear", rather than much else. This suggests (to me, at least) that in cases of a particularly expensive drug like Humira, a large proportion of the profits are not reinvested into R&D.

[1]: https://jamanetwork.com/journals/jama/article-abstract/25456...
> Nothing is preventing them.

Fear of the SEC is likely preventing plenty of them.
I didn't know anything about the film so I looked it up.

Spoiler: the summary given in this comment is not accurate and the film spouts a bunch of quackery.

He didn't eat he "recommend healthy amount of sugar," that would be no more than less than the equivalent amount in a can of soda.

He didn't get liver disease.

http://www.slate.com/articles/health_and_science/medical_exa...
And that is the problem with cryptocurrencies, everyone and anyone can produce on.
It's also interesting because Australia only has 25M people. All the others in the top 10 [1] are in countries with much larger populations.

[1] https://en.wikipedia.org/wiki/List_of_busiest_passenger_air_...
> I liked the explicit purpose of the community to not be a speculative instrument. You should always use it as currency and most users were against holding it as wealth. I guess they lost that battle to the speculative greedy forces.

Every coin lost that battle. Bitcoin was also intended as currency. At the moment, the amount of speculation far outstrips any legitimate use as currency.

The world has gone nuts. And what's worse, my co-workers talk all day about what Redcoin and Ripple and Verge are doing and whether they bought or sold at the wrong moment.
>It's a productive programming environment (for a certain type).

I'd go insane there. I need social interaction.
I thought surely you can buy ebooks on the Kindle app for iOS. But a quick search and you are right - nope, you cannot buy books on the Kindle app for iOS. The option just isn't there.
Given the age of the band, I'm not sure it's so raucous anymore
Changing the proof of work algorithm (usually) means relying on GPUs and thereby subjecting yourself to attacks from all GPU miners, whether they're currently mining Eth, or Monero, or Zcash, or any of hundreds of other coins.
The decent way is to unfollow them.
The food pyramid would be okay, if you’d actually eat the bread that the authors envisioned – full-grain rye bread, unsweetened, unbleached. That has a much higher fiber content, and much lower glycemic index.

Look at the images in the article. Notice the huge "unrefined carbs" part, and the tiny little "free sugars" part?

This is the bread the authors envisioned you to eat: https://www.baeckerei-guenther.de/cms/upload/sortiment/brot/...
That depends on age...handing a 4 year old a laptop is probably not feasible
I had some swelling in my legs and chest pains recently and had to make a trip to the ER. It was very difficult to weigh the threat of the symptoms against the potential cost of an ambulance ride and emergency care, and it occurred to me at the time how ridiculous it would be if I were sitting around performing cost benefit calculations before calling the police or the fire department. I've really been thinking hard about whether I want to continue living in the US as I age.
The theoretical basis for that metric, with stocks, is the whole being worth at least as much as the sum of its parts. That is, a buyer of every last share of Apple stock lands up owning a company throwing off $60+ billion a year [1]. A buyer of every last Bitcoin ends up with nothing.

I can't think of a non-currency asset that shares this property. For currencies, measuring the size of the monetary base can be meaningful. But it's not as meaningful as market capitalization is to individual equity securities.

Epistemologically, we cannot choose good summary metrics for Bitcoin until we know what it's useful for.

[1] https://www.sec.gov/Archives/edgar/data/320193/0000320193170...
Also interesting link within the article:

https://www.bloomberg.com/news/articles/2017-09-07/this-shie...

TL;DR Humira is protected by over 100 patents, covering how it's produced etc. That's partially what's preventing other companies from coming up with a replacement, despite the main patent having already expired.
I still fail to see how "economic inequality" is a bad thing.

If you accept that we will never be equal (aka aren't a communist) then the question becomes, what is a "good" level of inequality? How do you determine that? Does inequality increasing actually mean anything?

I'd argue inequality is quite meaningless. Especially on a national basis. Everyone can be equally poor, what good did lower inequality do then? Why focus on inequality instead of something like poverty? As Louis CK tells his daughter in an episode of Louis "The only time you look in your neighbor's bowl is to make sure that they have enough. You don't look in your neighbor's bowl to see if you have as much as them."

https://www.youtube.com/watch?v=Jtxuy-GJwCo
Reading the comments here, I wonder how many are aware of the use of social harmony which justifies this type of tech and why that core thesis is not identified and argued upon when compared to "more freedom is good". If this thought is too naive please point me to better reading resources
Pretty much the same story here.

Also I just checked my password manager and saw I had a bunch of Dogecoin sites. Tried them all. 5 out of 6 are completely dead, an one is just a price aggregation site.

Also Dogecoin blew my GPU at the time, luckily I got a free replacement from MSI.
Ask HN: How to generate a truly random and verifiable number online
I need to generate a truly random number. Of course, I could go on Random.org but it needs to be verifiable by anyone online. I need a public board or pure randomness.

I'm thinking something along the line of: "The number will be extracted at precisely 00:00 of the 21st January, from XYZ. XYZ could be the last digit of a stock price or something like that. Another idea would be to use the national lotto.

However, my problem is that the number needs to be between 1 and X and I don't know what X is/will be in advance.

I need to be able to get a verifiable random number between 1 and X which can be verified by anyone.

Is something like this possible? How?
Looks much better, good job!
Not really, no. Sometimes I accidentally touch the trackpad while typing, but rarely and it's easy to avoid.
Take the 2018 Stack Overflow Annual Developer Survey
> What is preventing every app/service to launch their own crypto currency?

Yeah, they will. Cryptocurrency in 2018 is the machine learning of 2017.

Startups will get asked "what is your blockchain strategy" instead of "what is your machine learning strategy".
at a restaurant, in a plane, in the train... it's so freagin annoying. The implied social contract that you use such devices with headphones go out of the way the moment there's "omg a kid so cute" involved.

Kill me.
I have found over the years that it isn't difficult to get useful content to surface on Google; the problem is that a lot of content isn't useful and is merely an SEO play.
Here's my modified version of Kill Sticky:

javascript:(function()%7B(function()%7Bdocument.body.style.overflow%20%3D%20'auto'%3B(function%20()%20%7Bvar%20i%2C%20elements%20%3D%20document.querySelectorAll('body%20*')%3Bfor%20(i%20%3D%200%3B%20i%20%3C%20elements.length%3B%20i%2B%2B)%20%7Bif%20(getComputedStyle(elements%5Bi%5D).position%20%3D%3D%3D%20'fixed')%20%7Belements%5Bi%5D.parentNode.removeChild(elements%5Bi%5D)%3B%7D%7D%7D)()%7D)()%7D)()

The nice part is that some websites do the stupid scroll block thing, where you can't scroll even after removing the elements. This script undoes that.

I'll give yours a try too.
Is that a typo or do you really consider a 1600 kcal/day diet a fast? Wikipedia lists 500-600kcal as usually being allowed on a 5:2 intermittent fast. https://en.wikipedia.org/wiki/Intermittent_fasting
Yeah...I think the generalization of smart phones being bad is the issue here.

As I pointed out in another comment I think we need to be more nuanced...I agree that YouTube is mostly just like TV with infinite channels...luckily it’s not the only App though...just think of the fun kids can have with google search or Wikipedia.
True, but sometimes just getting private key from the memory will be enough to gain access to the system as it could give researchers ability to build executable that will look like they came from the manufacturer/developer.
I may concede that it can perform “adequately at a lower price point” (I use Google myself when I am not in my hometown), but the parent wasn’t talking about price.
With their volume of transactions: no. As another comment said, they act as PayPal (same goes for Ali Express)
The higher level can catch the error, and context, and re throw.
More than 90% of the patients with end-stage renal disease are covered by Medicare (regardless of age).

“Perhaps no other Federal Government program can lay claim to have saved as many lives as the Medicare end stage renal disease (ESRD) program.”
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4194691/
There's a good long-ish read about why open-plan offices are terrible here: https://www.newyorker.com/business/currency/the-open-office-...