skysight-inc/HackerNews huggingface dataset:
This isn't news, nor is it necessarily even exciting. There are thousands upon thousands of chemicals that destroy HIV (bleach is a good example), the tricky bit is working within the confines of the human body. Delivery, dosing, etc, etc, etc. As far as drug efficacy is concerned, those issues far outweigh anything else.

Unless you are a drug researcher, ignore news of this sort, when you start seeing drug trials then you can start paying attention.
Interesting, this week I'm in the interview loop for a PM position at a notable company.

I come from a background as a botched startup founder & 'jack of all trades' consultant (developer / designer / project manager / team lead). Anyone have any advice? What challenges would I face in transition?
How many other people have half-started implementations of the same thing? That's why it's important to publish your code somewhere, even if it's "not good enough". Someone else can make it good enough.
I'm disputing the prediction that the future, if we remain on our current course, will be more of the same. Here's what you said, "If the past 40 years are a guide to the future". I'm disputing the idea that income inequality doesn't mean anything because the "poor" will have a higher standard of living that the middle class does today. Again, incomes are on the decline for most americans, and energy prices are rising. There is no way that we will get more of the same if that remains true.

Also, most people I know live in smaller houses than their parents, but that's purely anecdotal and based on the obvious fact that there are more people living on the same amount of earth. I happen to live in a major city.
WePay (YC S09) for Facebook
These look just as geeky as any other to me.
The WRX has been mentioned in this thread, that's one that I would definitely stay away from second hand.

People that drive those usually push them as far as they'll go (and further) whenever they get the chance.

MR2 is a great little car and about as reliable as sports cars come.
It seems obvious to you and many others here that everyone slides down the slippery spending slope. I have the same problem understanding this position that I have understanding "compulsive shoppers" who buy luxury goods on credit cards. Wouldn't one just... not do it? It seems that the type of person who overspends when rich will also overspend when poor, i.e. that it's more a function of willpower than income level. I don't overspend now; why would having more money make me any more likely to overspend?

I'm starting to think there's some major psychological division here; why is it so hard for you to imagine having willpower, or for me to imagine not having it? I'd like to say it's just that there aren't that many more things I want, but perhaps that feeling is a higher function of willpower, and I've just conditioned myself not to want things I can't afford. If this kind of cognitive shielding is involved, it might partially explain why the two sides have so much trouble relating.
A lot of folks were worried about the future of Sun's open source offerings, and it seems this might be the beginning of the end.
The US inflation rate over the last 40 years is readily available from the US Department of Labor based on the Consumer Price Index.

http://www.bls.gov/data/inflation_calculator.htm

$35,594 in 1970 got you the same as $200,000 today.

So why does it strain credulity to believe that $200,000 today will be equivalent to $500,000 in the year 2050? Inflation was much higher over the previous 40 years.
Interesting. One could have concluded that it was a bad example, but you concluded you have no overconfidence problem.
Ex-CEO of MySQL on Oracle, Open Source, Startup and Lessons of MySQL
Sure. I've yet to find a site that allows me to say, I'm in Amsterdam and want to fly somewhere for 7 days in October for less than 500 Euro, show me some options and a facet navigation to drill down further.

It's my most frequent use case, and I strongly suspect I'm not alone.
That again is a false assumption. I have professors who are great theorists but can't use a computer very well. It doesn't take computer savvy to be able to do computer science well. Hence my statement that you are confusing computer science and computer programming. The tutorials you see online are for practical applications. What you're seeing isn't computer science at all. Just a byproduct of it.
I think this has a chance of catching on.

You just have to find the right nitch to go after. Is it online dating (listen to the mixergy match.com interview - their key was gaining women's trust)? Do people want to talk face to face before going out on a date? Could it be founders looking for founders? I don't know. But what I do know is that you should find a segment that could benefit from this the most and go after them. Who's pain is the biggest in this area?
A version of Rapportive is featured (free) in the Google marketplace. See http://www.google.com/enterprise/marketplace/.

If that doesn't settle the fairness aspect for you, take a look at http://code.google.com/apis/gmail/gadgets/contextual/ - improving Gmail is something Google is interested in.

Edit: Rapportive's listing specifically can be found at
http://www.google.com/enterprise/marketplace/viewListing?pro...
Do not put seriously ill anywhere on your resume.

So what if you got bad grades as an undergraduate? If you did ok on the masters, everybody will think that you was a lazy guy who's grown up since then. Also, if your grades where remarkably bad, don't put those in. People will assume they were average bad, now awful.

On the other hand, if you disclose you have had serious health problems, you raise a yellow flag. Does not matter if you have no long term sequels, if there is a suitable candidate with no yellow flag, H.R. is going to take the safe bet. You will not even get a chance to explain yourself.
Shouldn't that be 'if DuckDuckGo tanks'? Or do you know something I don't? ;-)
Given that Rapportive runs client side and has full access to browser internals, I'm sure Google would lose the Rapportive-detector war.
Times are different. I walked to school since kindergarten, but no way I let mine when it came time. (Certain years we drove just because we lived where there were no bus routes, and making a small kid walk that far with heavy backpacks just never made sense from a time POV.) Imagine that though, they actually survived my paranoia.

But now? No way unless they were a few years older. NYC needs to watch more of that news they dismiss: Attempted kidnappings happen a lot in the burbs. All paranoia is local though.
I don't really get the obsession with wanting to be retired at 30. What would you do for the next 60 years? Honestly, the math here is pretty encouraging. If you're the founder of a company that makes a smallish exit, you've just freed up about 20 years of your life when you've only been alive for 30 years.
How to Travel 12 Countries with No Baggage Whatsoever
If you need more than one line, you can say

git commit -F -

to specify that the commit message should be read from standard input.
that should probably be network advertising
North Korea: We Didn't Tweet, It's A Filthy Western Habit
Or it could be the start of the community building something from the Solaris source?

Here's a blog post from Peter Tribble, one of the ex-OGB members: http://ptribble.blogspot.com/2010/08/new-light.html
Vancouver, Canada: $72,500/year
Toronto, Canada: $65,000/year
Hamilton, Canada: $55,000/year
Halifax, Canada: $47,500/year
as an addendum, since none of the results seemed overly technical to me, here are the "technical" words they used to gauge geekiness:

CS, Clojure, Debian, Haskell, JavaScript, Python, Rails, Scala, algorithm, compiler, engineer, frameworks, jQuery, macros, open-source, process, servers, stack
Although iOS will have lower market share than Android, the iPad will probably have higher market share than any individual Android tablet, and thus the hardware economy of scale actually goes to Apple.

Also, is there any additional economy of scale beyond, say, 10M units per year?
'Muslim' harassed at anti-mosque rally
From most accounts he is Puerto Rican but that didn't stop the mob from nearly assaulting him.
Mutual organizations sound like credit unions.

Thanks for writing that very detailed response, there is lots of concrete information in there.

I've visited Latin America several times, Bogota, Colombia and Coronado, Panama but never got around to visiting Uruguay. I hear lots of good stuff about Costa Rica as well.
Will Windows Phone 7 users buy apps?
Funny that you should try gaming it. This week we're using the platform to do blog comment spam filtering. Is the comment off-topic (or just not on-topic) for the post?

Edit: To clarify, I was just saying that we have spent a lot of time today thinking about how these things can be gamed by evil spammers, not calling anybody or anything off-topic; apologies for any confusion
More to the point, of course, is how much you will have to work to have that number of nominal dollars.
Heh, yeah. Add a 10.1 there then that says "Ignore future infinite loops" :)

There is something we all need to remember.

-Have a great time doing it.

It's one in a life time experience. Find good people to do it with and rock the hell out of your market :P

Cheers!
Maybe you just picked the wrong building? The only noise I hear from my neighbors is when the windows are open and the kids are screaming two doors down. But no insulation is going to fix that problem.
Bathroom Monologue: You write a lot.  What's your secret?
I like this explanation better:

Intel CEO: "We need antivirus, can someone buy me McAfee?" Few hours later: "Done." "Great, which version?" "Version ... ?"

(From http://twitter.com/paulmutton/status/21646042097)
Ask HN: How to recruit video chat app hackers?
I have experience looking for fairly "standard" sets of web skills, but my company is now in a position where we need to build a native two-way video chat application. This goes outside my area of expertise, from both a technical and a procedural perspective.

The app we're building is really cool and very unique, and we need to build a top-notch team to pull it off. I've done a quick scan of the major job boards for representative examples, but haven't found anything.

Is this an uncommon need? Any advice from the HN community?
Ask HN:A script writing mediawiki gig for you.
Hi,

Note to the Mod: I haven't seen small gigs like this posted here before so if this is out of place please delete it

I operate a website that uses mediawiki and I use it to categorize software (and other) tutorials I write. The way that I do it is I write the software name, colon and then the tutorial topic.

here's an example for clarification

http://en.wikiaudio.org/Category:Reaper

What I'm looking for is somebody to write a script that automatically hides the colon and anything before it from being displayed in category listings.

I would make browsing easier.

This a paying gig of course.
admin@wikiaudio.org

Thanks
Yeah, exactly. I rarely have to call out to C in my Haskell applications. When I do, it's only to get or send data to a C library that I don't want to rewrite.

Internally, things like Data.Vector work just like the C equivalent. The internal representation of the data is the same (i.e., Vector.Unboxed Double == a big block of memory with CDoubles in it), and the machine instructions that run on the data are the same.

High-level languages need not be slow. It's just that Perl, Python, Ruby, and PHP are.
I ran a modestly successful affiliate site from 2002-2006. I did very little work, and could have done much more to succeed (in retrospect), but it did provide 20% of my income during that time. I recently attempted to relaunch the site after a few years away, but found that the market is much tighter than before (I made only a handful of sales during a two month test run; I also believe that consumers are now more skeptical of affiliate marketing sites.

I think that given the right market and some hard work, it's possible to make enough to live from affiliate marketing, but I've found that I prefer to work with friends on more ambitious projects.
So has this strategy of ad replacement been officially blessed by Google?
tl;dr:

Introduction

zsh is UNIX shell.

So what’s zsh and why would I want it over my current shell?

It's more bloated than just about every other shell! Bash isn't nearly
bloated enough! Feature, features, features!

Ok, You Convinced Me. How Do I Start Using zsh?

Of course I did! One catch though: You need a big config file to get
access to all that bloat.
Ask HN: running startup as a sole proprietorship until you receive funding.
So I am entering an agreement with someone who is starting up a company. He asked me to work for the company in exchange for a percentage share, and the agreement states that until the venture receives funding it will be run as a sole proprietorship to save on legal fees. Is this a good idea? Are there any risks, for me or for the startup? I'm not familiar with the legal aspects of business, so I'd really appreciate the guidance.
Congrats on the writeup Rahul, Sam, Martin, and team!
My favorite part: "They invested over Skype, which was kind of cool, and we all got drunk that evening.”
Honestly, how likely is it that the demographic using Rapportive is one that clicks on ads? I would imagine there is essentially zero money lost for Google.

Besides, how is this different than ad blocking? I install in my browser plugins that improve my browsing experience. That includes flashblock, adblock plus, pop-up blockers (a feature historically so popular that it is now built-in the major browsers), and other addons that alter the content I see on the web page.

Another example: People share hosts files that block different annoying services like intellitxt and Snap Shots. This is no different in this regard.

Rapportive is actually better because the space previously used by ads that I would never click is now actually useful. It's a step forward from simple ad blocking.

Edit: various grammar/clarity fixes.
I believe you can. Some rough estimates:

- 3 room house on nice neighborhood $150,000 USD

- A 2010 Toyota corolla. $15,000 USD.

- A maid visiting twice a week. $1,700 USD a year. (This is really nice!)

- Private school for kids $3,000 USD a year for each kid.

- Dinner for two twice a week. $3,100 USD a year.

Edit:fixed number formatting
Google's Android Market License Verification Easily Circumvented
it seems to me that predicting the distant (20+ years) future based on the past never really works out.
"These days, most Gmail users never even glance at the ads filling the right-hand column."

What sort of idiot writes that. I mean seriously. Do people really believe that Google just serves up those millions of impressions for the hell of it with no payback?

People look at them. People click them. Google makes a ton of money. Advertisers get a shedload of traffic.

It's an absolute douchebag move to mess with other peoples content. Reminds me of the free wifi services that inject their own adverts at the top of every page on the internet, or rewrite affiliate links etc. I don't care if this plugin is useful or not, I don't want it to mess with the DOM.
Yes, but disclosing it in the resume/CV is way to early. You are basically asking potential employers to pass on you before you have a chance to show how valuable you are.
How does that help? I can change my server every second. The only way rapportive can change their parser is to get the user to download a new version.

In fact it's quite the opposite of what you're claiming.

And anyway, sod the browser internals. Google has lots more lawyers than rapportive. That's who'd win that fight.
EDIT: Daring Fireball just linked this ridiculous story (with a big old selective quote), right on schedule. Now that Gruber has led the way, expect it to appear on many other iPhone/Apple sites over the coming hours.

So predictable.
"most people I know live in smaller houses than their parents"

But do they live in smaller houses than their parents lived when they were your friends' age?
Cooking for Geeks Book Tour: Where should I go?
Kodak intros world's thinnest 5x optical zoom camera
there are guys pushing a few hundred thousand dollars worth of offers a day. It's a huge huge industry, but you can't just toss up some banners and expect to profit.
The job of product managers is not to know, it is to learn. Far too many people have that backwards, including product managers. The best ideas rarely come from the product manager. But the best product managers do a good job of finding ideas that are out there in the users, QA department, developers, etc, and figuring out which ones deserve to be tried, how to integrate them into the product, and how to judge their success.

I remember one product manager. Her first time being a product manager in software. I handled reporting. Within 3 days I knew she was good. She knew absolutely nothing, but she asked the right questions, and put the answers together in good ways to come up with insights other people hadn't had. I was on my way out the door, but I kept in touch with the company. I was entirely unsurprised that 6 months later she had emerged as a superstar.

Still there is always a challenge in telling the difference in an interview between people who are good, and are good at BS. This seems to be particularly true with product managers. But I suspect (never having hired for the position I can only suspect) that digging into their willingness and ability at asking questions is revealing.
Some ads are CPM you know... eg aim is to get exposure / mindshare rather than traffic.
I use etacts.com, which seems like the exact same thing. Is there a difference? I think the major benefit to me is mainly just to see the person's face. It helps humanize the person on the other end of the email, and often prompts my memory if we've met before.
Rypple gets Pivotal Tracker Integration
What if you could combine "no intellectual privileges" (and therefor unlimited and natural dissemination of intelligence throughout the population) with an unconditional basic income for every citizen? That way "creatives" are payed enough to take the money issue of the table.
Sense Of Entitlement? TV Show Creator Wants A Cut Of Hulu IPO Proceeds
yes, thank you!

and I've sold non-iPhone software outside the App Store so I know what the alternatives are like. It is definitely a bigger challenge getting eyeballs but is better in most every other way.
http://news.ycombinator.com/item?id=1624312

http://news.ycombinator.com/item?id=1623241

Also, from http://ycombinator.com/newsguidelines.html

> If you submit a link to a video ...
> please warn us by appending [video]
> ... to the title.
BTW, I didn't mean to imply that the Dutch are cheap. I just thought that their overwhelming interest in an app that provides a more fair split of the check (versus an even split) is indication that they do indeed like to "Go Dutch" (ie split the bill according to what people ordered)
Startups are stepping stones.

Where I grew up in Ohio, there were two kinds of jobs: entry level jobs that paid nothing, and jobs for older people and experienced professionals that paid well. There was nothing in between.

If your city has no "startup scene" (no entrepreneurship), then there is no class mobility. People have to leave to move up, and they often never come back.
I can't think of a fix for paying people for their votes since that problem still exists today (albeit to a lesser extent than if a voter's vote were verifiable), but I imagine they wouldn't be able to keep it under wraps for very long. Anyone offering to pay money will definitely risk drawing attention to themselves, and I believe ethical people will report suspicious people to voting investigators.

As far as the UUID/pair frauds, we could mail a confirmation letter to the voters stating that they voted. Since I don't think we could tie the UUID to the actual voter, we could tell them they participated in this year's election and to verify the results to the receipt. This part is compounded in difficulty partly due to federal voting regulations that don't allow us to tie a voter to his votes, so I think the only real way is to verify videotapes verifying that said voters appeared in person to vote.

Again there are flaws and it will take more people to resolve the issues with electronic voting.
No love for the iPad either. was looking forward to making a streaming dashboard with this
Very cool! They have just made themselves visible to 500 million people.
Wrong, the apps version looks totally different. Check the screenies:

http://rapportive.com/google/home

Rapportive is at the bottom of the screen, not at the side replacing ads.

So no blessing by Google.
There is a big difference between that and going from poverty to upper middle class. By your logic those stuck in poverty in 1967 will now have graduated to upper middle class by 2010. Even if that is how you define middle class I don't see very great strides. I rent because the housing market is a mess (http://seekingalpha.com/article/115464-new-home-prices-vs-me...), I wash dishes by hand and don't care for an iRobot vacuum with a state of the art cat fascinating feature, health care is very costly or down right unattainable, but yes I do enjoy my Xbox 360. It hasn't convinced me of your point though.
Why SLAs are redundant, but Zencoder offers one anyway.
Well, it was closely related to the comment I replied to, but that comment was probably off-topic for the thread.

Generally, if you put "sp332" into http://www.swimwithoutgettingwet.com/discourse/hn_comments/ the comments around 75% are all on-topic except #5. I don't understand why #14, "Update: nope." gets a rank of 62.09?
It doesn't matter what type of ad, it is getting blocked anyway. Besides, banner blindness is why these things don't perform well. The CPM ads have, usually, very low CPMs.
But the bacteria growth in Petri dishes is limited by resource, and bacteria has no way to change the situation.

Maybe we are really limited by available resources. We know for sure that we have limited supply of the solar energy. At the other hand, we are just using what is available on the surface of the Earth. Maybe we are going to figure out how to utilize more resources outside the surface of the Earth, or efficient way to use and recycle resources.
Trains are a fair bit more expensive than buses. We don't want scrappy startups sending mixed signals ;)
I agree with what you're saying in terms of the ads. But if I'm Google I let the social CRM players duke it out as well as play with alternative ad models - pick a winner and acquire them. Then I can do what I want with the competition.
Actually these days I'm not even sure which is more offensive, Mac OS X which has always been smugly bastardized Unix, or Ubuntu which has most recently been making everyone think their crappy Linux modifications are the only proper ones (and making "Ubuntu" synonymous with "Linux")
Changing the content of someone else's page in flight is already murky enough when translation services do it, but when you actively start messing with someone else's revenue stream I feel some line has been crossed.

That line is probably labelled 'symbiotic' on one side and 'parasitic' on the other.
Scala, my pet python, bit the rails of his cage's framework wide open-sources say the process takes stacks of CS (chewing sounds).
sounds like a bet that corporations and consumers will return to buying PCs in the very near future since they have delayed their purchases because of the recession.
Automatic Detection of Vulnerable Dynamic Component Loadings
So a new strategy for acquisition is to mess directly with someone else's revenue stream? Instead of building a competing product with the feature added?
Not sure why you're being downvoted. I laughed!
20:20 Vision - IT Skills Needed
I think one big strength of RDoc over other documentation formats is that it gives the README a fairly prominent place. Seeing a few usage examples, high level thoughts makes using a new library so much easier.