skysight-inc/HackerNews huggingface dataset:
If you mainly work in one place, the current Mac Pro is great for developers. I still travel with it but it is to another house where I have a monitor and keyboard setup.
Brown, green, hazel eye colors are variations in the amount on melanin in the iris. This amount can change as one gets older. Babies can have lighter eyes that become darker.

Blue eyes are believed to be caused by an isolated, inherited gene, OCA2. This gene is present in all people that have blue eyes. It disables the production of melanin in the iris.

All blue eyed people are believed to have a common ancestor from 6000 to 10,000 years ago, the first person with blue eyes (originally caused by a random mutation). It’s harmless enough that lots of us have it now.

See [1].

[1] https://www.sciencedaily.com/releases/2008/01/080130170343.h...
The very moment neo-feudalists appropriated the label "libertarian" from the left-anarchists.
For one, it would give the resulting entity a majority stake in Hulu and control over a lot of content that they could potentially yank from the likes of Netflix. It's also the default position of regulators that horizontal mergers are bad for competition, so I'd expect a fight regardless of the ultimate basis [1].

[1] https://www.ftc.gov/tips-advice/competition-guidance/guide-a...
See my reply to ak_yo.
Nwzer: Artificial Intelligence and Blockchain Powered Citizen Journalism
> One caveat with Bitcoin is that the network is so slow (effectively just 3 transactions per second) that a crash would be spread out over time.

This is false, the majority of people selling already have their coins on coinbase or other exchanges and would not add to the transaction volume hitting the blockchain.
Are you saying ideas you consider inherently dangerous are good candidates for censoring?
Great offer. I am self-taught (to some extent). I would like to get involved in your code review n
Decentraland: The new platform for exchanging virtual goods
Security Evacuates FCC Net Neutrality Vote Meeting
> anymore

and I'd also add "to the best of our armchair knowledge"
"You bet"? This is one of the core questions in human genomics/health research today and nobody has been able to make a convincing argument in general that your proposed approach would work.
It has all the important functions like left-pad.
FCC evacuates during net neutrality vote ‘on advice of security’ – The Verge
I hardly see him presenting China as a bastion of freedom. But I do understand how one could feel safer voicing their mind on a certain subset of topics among a crowd of Beijingren versus a crowd of San Franciscans.
Also Quran 46:15:
"And We have enjoined upon man, to his parents, good treatment. His mother carried him with hardship and gave birth to him with hardship, and his gestation and weaning [period] is thirty months. [He grows] until, when he reaches maturity and reaches [the age of] forty years, he says, "My Lord, enable me to be grateful for Your favor which You have bestowed upon me and upon my parents and to work righteousness of which You will approve and make righteous for me my offspring. Indeed, I have repented to You, and indeed, I am of the Muslims.""
What about whataboutism?
Periscope! Interesting!
CBSN has a live feed showing the empty room after it was apparently cleared by security.

https://www.cbsnews.com/live/?ftag=CNMe94798
At this point both W3C and WHATWG are not where innovation on the web is (or should be) happening. It's up to the individual browser makers to innovate. W3C and WHATWG's job should be to document any consensus among browser makers.

It shouldn't be their job to decide how browsers should work, that's the browser makers' decision. (Which happens to be large corporations, for the most part.)
Those things are part of the reaction I describe. The right is also creating its own enclaves.

I would not be surprised to see the United States physically fragment and balkanize in the next 10-20 years. I get the sense that some on the hard-right and possibly also the hard-left have that as a goal.
The crypto market trades more on sentiment first, then technicals.
"microbiome" therapies has been one of the hottest areas in biotech the last five or so years. some of the hype has died down, however. microbiome therapies work well in c. difficile infections and some other gut diseases. in this case, you give a patient a set of "good" microbes that fight the "bad" microbes (c. diff).

people are studying microbiome therapies for cancer, autoimmune disease, cns disease, etc, but its way too early to tell if any of it is real. there are many challenges: how do you ensure the microbes you administer stay in the body, colonize, and actually produce the molecules you want them to? how do you manage the risk that they interact with other microbe populations in ways that are impossible to predict accurately, but potentially very harmful? how do you manufacture these things in a consistent, high quality way? what is the regulatory path? how do you justify a huge risky r&d investment when you can't patent a microbe? not to mention the biology risk; the "microbiome thesis" sounds nice, but how confident are we that microbes can treat cancer, depression, parkinsons? right now, not very
Love this paper.
I've lost quite a bit on bitcoin between nicehash and now having trouble withdrawing my money from bittrex.

Also, have what's probably $1000 or more floating in the bitcoin and splits void because I lost my private key.
Listen to this debate

https://www.intelligencesquaredus.org/debates/free-speech-th...

plenty of examples by the side arguing for the motion.
Can't you just snap one window to the left and the other to the right of the screen? That's built in to Windows too and should give the same effect as two fullscreen monitors unless I'm missing something.
Come on, it's $5000 and you can't upgrade the RAM.
Thankfully artificial pancreas are looking like a good option until we can get to curing type 1. Not only does it save the number of shots like pumps we have today, but it can measure the sugar level and keep the swings down to a minimum. http://www.jdrf.org/research/artificial-pancreas/
We’re barely using the best tool we have to fight obesity
React Article: Components, Elements, and Instances
Also, backed by the Google Digital News Initiative: https://medium.com/@karimmaassen/nwzers-wisdom-of-crowds-mac...
Yeah, someone always brings up mining, Alaskan crabbing (was it crabbing?), etc. Anyway sure, 4 years ago we had the same conversation... I guess someday greed might overcome the risk. Still, the lawsuits over loved ones could get expensive.

My observation is that we can start immediately with attainable goals, at a cost we'll likely accept, with no risk of human life, and with immediate economic and technological benefits.

In the meantime, we've lost 4 years... with another decade more with no real goal.

My suggestion makes forward progress every year. At some point, sending humans to Mars, for example, becomes a small inexpensive step, rather than a giant costly leap.
I really don't get why people are upset about this. A company trying to make money by going for mass appeal. For shame.

Until someone shows that an unsafe movie can be popular it's going to continue just how it's been since Gilgamesh.
Okay but how do you solve that? You take away the right of companies to fire people for speech? I see no way to increase freedom from the status quo here.
"Love letter to developers"?! If Apple wants to send me a love letter, they can tell their design team to put 32gb of RAM into a MacBook Pro that has an upgradeable drive, expandable memory and a reasonable configuration of ports.
Since not everyone regularly submits to HN, I think reposting the link from the footer is relevant:

https://news.ycombinator.com/newsguidelines.html

"Hacker News Guidelines

What to Submit

On-Topic: Anything that good hackers would find interesting. That includes more than hacking and startups. If you had to reduce it to a sentence, the answer might be: anything that gratifies one's intellectual curiosity.

Off-Topic: Most stories about politics, or crime, or sports, unless they're evidence of some interesting new phenomenon. Ideological or political battle or talking points. Videos of pratfalls or disasters, or cute animal pictures. If they'd cover it on TV news, it's probably off-topic."

This isn't anything groundbreaking as Harvey was already exposed, this is just another data point.
Why does he think all this is so funny!? Ugh!!!
FCC evacuates meeting room due to security threat just before net neutrality vot
I'm giving Sam the benefit of the doubt that he's just trying to make a point and didn't think that line through.
> Talk about effort not time

I can't understand this. You can measure time, but you can't measure effort directly, unless you're maybe doing some physical work like pulling weights. Also, you can't usually increase a mental effort, except by spending more time (e.g. by working overtime).

I can only see points or other non-time measures as proxies to time intervals (with uncertainty), but we can't know the function points -> time beforehand, we can only measure and map it from experience.

If you could explain "effort" from some other angle, I'd be grateful.
I totally expect that the next administration will create new regulations. Then the next administration will remove them. Lather, rinse, repeat.
HAHA Autodesk strikes again. Google should buy them..a match made in heaven.
I agree with you.

The best argument for life extension here would probably be to say that technologies like cell phones, which we now consider to be liberating technologies that almost everyone can afford -- even people living in poverty -- also started out as affordable only by the ultra-wealthy, and there's simply no way to arrive at a new tech without going through that stage.

If the tech were only useful to the ultra-wealthy once developed, that would be a flaw demanding criticism. But criticizing a technology for having a first stage of not being affordable before it becomes more affordable later seems to miss the mark.
>Isn't this just asking for your ideas to not be criticized?

No, he's asking not to be critisized for his ideas. And it's troubling to me that you think what you presented is a proper discourse but I guess that's where we are today. The "someone else" in your example is simple minded and potentially dangerous in large enough numbers. It is not at all a given that people living longer would be disasterous for the environment [1] and therefor, no, people working on this may not be unethical.

Your "someone else", whom you seem to think responds in a completely reasonable manner, makes a highly oppinionated statement and then judges people based on that oppinion. How far is it from "they must be unethical" to "we should boycott their means of feeding their family" or even "we should probably put them in jail before they do something bad".

[1] In fact I find the idea beyond ludicrious. If people live longer, they're likely to put off having children until much much later (people in the west already wait about as long as they physically can). Further, if people like the Koch brothers knew they would have to stay on this planet for 10k years maybe they wouldn't be so willing to destroy the next 50-100 years for a nice 5-10 now.
It's interesting that even after all the scummy things the movie industry has done, people still desperately want to pirate their content. People who base their opinion on a principled opposition to copyright, should be leading the charge in promoting other means of compensating content creators. Stop signalling how much you desire the copyrighted product, and start signalling how much you desire the non-copyrighted one! IMHO The only people who should be pirating are the people who don't have a principled stance on copyright.
> We need to accept that some of these ideas ... are inherently dangerous.

This line of reasoning leads to censorship. It's the same line of reasoning used by every dictator and demagogue as well as China today. Why? The idea of democracy seems dangerous to a king.

Ideas are not dangerous. Ideas are never dangerous. Ideas acted upon might cause danger or harm, but an idea itself never does, never has, and never will cause harm directly.

Open debate of ideas, or the testing of opposing ideas to find the best among them, is necessary for progress... not only to find and establish new ideas, but to question widely held ideas today in the hopes of finding something better. To have open debate--to find the best ideas--you need to listen to ideas with which you might not agree, or which you might find--if acted upon--dangerous.
I agree there are lots of reasons to be discussed, but it's my understanding that access to postpartum healthcare is certainly one of the factors, one that varies widely by insurance company. Medicaid, for example, only covers two months of care for mothers after they give birth,[1] and even then care compares poorly to other countries with more equitable healthcare systems.

[1] https://www.npr.org/2017/05/12/527806002/focus-on-infants-du...
Detection of FRB 121102 at C-band using BLGBT
IIRC, Fox sold Firefly to Universal for Serenity.
Borges work is available in two translations, one done by a friend in cooperation with Borges, one done after his death when his wife commissioned a new translation to avoid paying royalties to the first translator.
> I keep hearing that from people saying things like...

Are you actually hearing that, or are you reading someone else's disingenuous over-simplified interpretation of what someone else said? Maybe just doing the incorrect reading yourself? Or are you reading an anonymous 4chan one-liner that could have been posted there by anyone for any reason?

> What if the ideas are unethical?

Then explain why. If you can't explain why something is unethical without resorting to intimidation of the people expressing those ideas, then maybe they are more ethical and your concept of righteousness is flawed or missing something important.
David Silver's Keynote Speech at NIPS 17 on Deep Reinforcement Learning
I'm rather assuming OP was referring to the sort of culture that produces this sort of discourse:

http://quillette.com/2017/12/11/problematic-poor-taste/

If the US Academic reaction to such a straight forward request was so hostile, then I can imagine many people feeling unable to voice actually difficult opinions
... pardon my assumption, but those four people don't look like college students. Are they?
Sure you can - if the intent is to destroy the free Internet that exists now.

Follow the money.
I remember they mentioning it during the iMac Pro announcement. I think it was Phil Schiller.
I mean. I guess not all love letters need to be reciprocated so I'll save my nits on the headline.
Yet the economists they're mocking were asked about bitcoin.
looks amazing! mind giving some insight about the stack you used to build this?
Because the whole point of a market is that it acts as a process to discover the most efficient way to do something in a complex system.

Every individual market has huge amounts of complexity by itself and competes for the same resources as many other market creating huge amounts of complex dependencies.

If in these system a particular structure emerges, there is reason to think that it is actually pretty efficient compared to most alternatives.

Just willingly going around trust-busting because 'cooperation are evil' or some other popular phrase is a terrible idea most of the time it will hurt more then it does good.

If you want to do something useful make sure the citizens have rights and that there is a good legal system to arbitrate the interaction of people, companies, non-profits, clubs and so on.

Real change happens because a change in the rules of the system, not in a temporary heroic political trust-busting campaign to score political points.
That's why I stopped using FB. The last election unhinged some of my friends, and it became tiresome.
Cryptocurrency dashboard for traders and investors
My son also has hemophilia A and I'm fascinated by the possibility that he may someday join one of these trials.

The increase in the pipeline of gene therapies just in the past few months has been incredible.

Here are the ones I'm tracking:
BioMarin valoctocogene roxaparvovec (BMN-270)
Spark SPK-8011
Sangamo (Pfizer) SB-525
Bioverativ BIVV-001
Shire SHP-654 (BAX-888)
Will add Amazon pulling Twitch from the Roku as additional anti competitive behavior than just the banning of Chromecast.
And Tesla.

Oh wait, too soon?
https://app.put.io/ Put.io is absolutely the best way to download torrents. I am not affiliated with them in anyway except that I am a massively happy user, and assume you will use this service only to download legal torrents, like me :)
You’re leaving out the part where B whips up a Twitter mob to demand A be fired and ousted from the industry.
Which is a nice hypothesis, but Nielsen says it isn't so : http://www.nydailynews.com/life-style/average-american-watch...
I moved to ATL (midtown) in '07 and a car was a basic necessity.

But today? I think I could easily live in the midtown area and not need my car. I mean, I'd walk to Whole Foods from 10th and Piedmont regularly (there's a shortcut at the TJs ;P)
What’s in your Android’s December security update?
If a lender is going to approve a sufficiently large loan to someone with $200k in student loans and tax debt, and without a high income, they would not be in business for long.
One of things no one talks about: correlations. I have seen several of people lose their careers after become right wing spokespeople. These people work in difficult, ambiguous fields including patent prosecution (IP Law) and network security analysis. The fields are all about considering probable outcomes from ambiguous or untrustworthy data. They weren't pushed from their jobs; they stopped being able to juggle the ideas. Both employer and employee wanted them to leave by the time the left. They never succeeded again.

This terrifies me.
Link to the actual product: https://www.photopea.com/ Nice photo editor. Cool that you can edit photoshop files online.
My reaction to that would be to tell them there’s exactly one correct way to treat people. As soon as you categorize someone not by what they reveal about their individual characteristics you’re being prejudicial. An individual will reveal that they’re more likely to commit crime in individualistic ways, for example. Ie pulling up a criminal background check is Ok (though you’ve got to read the contents), but segregation by skin color is very definitely not.
There have been low transaction fees in the past and they can return. Currently that is not the case.
So it's similar to how HN competes with Reddit?
The original comment was not suggesting that all genetic diseases and cancer (!) can be easily cured. Based on similar techniques, many single-gene disorders are effectively cured. Unfortunately, our disease-specific drug approval process does not scale and prevents us from realizing the benefits of these techniques and technologies.

As a personal example, a close family member was recently diagnosed with shwachman-diamond syndrome (SDS). I have confirmed with multiple leading physicians (Dana Farber, Mayo Clinic, etc) that all of the tools necessary to cure her are presently available. At a high level, this would involve:
1. Extracting marrow.
2. Isolating blood-cell producing stem cells & amplifying in a dish.
3. Modifying using a product like [A]
4. Validating/re-sequencing to confirm transduction.
5. Re-insert modified cells into patient.

Yet doctors can't engage in this work without going through the lengthy drug trial process. So instead, they recommend much riskier treatment options including some that would complicate future gene-therapy attempts.

[A] - https://crispr.sigmainformatics.com/templates/CRISPR%20Custo...
> Was interesting until I saw this.

> Good for decorative concrete, though.

It goes far beyond decorative concrete. This process can be used for concrete blocks, roof tiles, drainage pipes and boxes, prestressed slabs, and virtually any other product that is manufactured off-site.

For the record, I don't think I have ever seen a basement where the walls were solid pour. It's a waste of concrete when hollow block with poured columns is sufficient.
Looks like it's happening:

"Modified blood stem cells reverse type 1 diabetes in mice"

https://www.diabetes.co.uk/news/2017/nov/modified-blood-stem...

And type 2 got cured by an extreme diet in 86% of patients:

https://sciencealert.com/extreme-diet-reverse-type-2-diabete...
FCC hearing room evacuated ahead of net neutrality vote
I'm just excited to see the full-width bluetooth keyboard with numpad. Unfortunately it doesn't look like you can order it on its own in spacegray color (call me vain but it looks fantastic!)
Fearing damage to your reputation if your ideas are unpopular is literally how society works. Unethical ideas aren't just unethical out of the ether, they usually involve harming someone or some group. Putting those ideas forward should come with risk to yourself because it definitely comes with risks to others.
It's an interesting project, but I'd never rely on it without some idea of what the goals are. Why isn't it open source? What's the business model? Will you charge me $1000 in two years, once I become dependent? Will it stay online in two years? Etc.

There's a certain transparency lacking.

It's fine to say "It's free for now, and will be $0.50 per month once mature" or "We plan to make it free for open images and charge $5,000 for proprietary use" or whatever. Or "We'll support it by doing machine learning to find naked images and pay for it by hosing a porn web site." Or "I'm developing this until I can sell it to the highest bidder."

But there needs to be some answer as to what the goal or business model is.
The right control experiment here would be to do more business in other areas.

Open a YC branch in another city. Sam and other partners can spend more time there and find out if it really is more conducive to new ideas.

If the other location(s) really does turn out to be more conducive, ramp it up and close down the Bay Area operation.

Maybe the Bay loses out, but other places and the wider world win.
Did you know that in an efficient market lower cashier prices equal lower food prices?
The results of a straw poll after a debate are not evidence for anything beyond what the people who saw the debate thought of the debaters. People vote for all kinds of reasons - the underlying merits of the case, the impressiveness of the speakers that they've found to present it, even sympathy for someone who got obviously crushed by their opponent. When I was a debater I've seen some truly outrageous motions get passed simply because one side was funnier.
Show HN: Flockport – A massively simplified alternative to docker and kubernetes
What If Loki and Kylo Ren Were Roommates?
While you're right in theory, in practice, the OP is right. Pai is chair because Trump was elected, the balance of the FCC board was skewed because of this as well, and so the only thing between us and a non-neutral internet is now gone.

In an ideal world, we would pass a law demanding ISPs provide neutral service. However, this is far from an ideal world, and that will never happen.
Can you expand on the last part? I don't view a publicly accessible webpage as a protected private space, just as I do not view an ad posted in a (private) window as a protected public space.
golem looks interesting from a technology prospective. Lbry is minable if you have a GPU.

if you want to get your feet wet just buy a GPU and start mining.

you can checkout whattomine.com it's pretty accurate.
I remember hearing the lack of a 32GB option was due to the chipset or something.
Ah that’s fair, different cultures will have different heresies.
Google Play Gift Card Code Generator 2018
It does not make much sense to use avg tx fee to see if a currency is suitable for micropayments. You should be looking at the min tx fee.
I hate Facebook with such a passion I really hope this is true.
The State of JavaScript – 2017