skysight-inc/HackerNews huggingface dataset:
Yes fast track and breakthrough destination and priority review allow you to cut review time down and get more FDA input on your dev plan, but none of them allow you to ignore getting safety data as the person I responded to said.

Accelerated approval actually does reduce the number of studies you need to do to get approval. One of the reasons cancer is such a hot space is that FDA has been lettingamy drugs get accelerated approval from phase 2 studies looking at tumor response endpoints or progression free survival, rather than overall survival, which is a more relevant endpoint but one that takes longer to measure

I work in the field and find FDA is generally ok but I've been in situations where FDA used its power to enforce its will based on internal politics rather than scientific evidence. Very discouraging but that isn't the norm
The DEFCON guy used 15 grams of thermite. An AN-M14 TH3 incendiary grenade contains ~750 grams of thermite (technically thermate). Those are two different things. Entirely.
Experts Say Universal Basic Income Would Boost US Economy by $2.5 Trillion
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Canonical is the company behind Ubuntu Linux. We are a globally distributed team passionate about open source. We're looking for python/go developer who has devops experience and a test/QA passion to join our juju engineering team. Juju is a modeling and software orchestration tool that is capable of deploying to clouds, containers or bare metal.

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> Stoker could, for example, have sent Valdimar an older version of his story

Back in the old days, I could see happening as purely a mistake and considering how global communication worked then I can certainly see this not noticed for quite some time. Stoker's publisher could have grabbed the wrong manuscript and sent it out. Considering the Amazon reviews claim that the second half of the book is, at best, a rough outline, then I'm guessing this is probable. It sounds like an unfinished and abandoned work that somehow got into production.
Unfortunately not open source, but BazQux is an excellent RSS reader written in Haskell: https://bazqux.com/faq
Unsolicited suggestion: try https://www.regenexx.com/

I have following Chris Centeno, M.D. for some years. As far as I know he tries all/some approaches including stem cells, chiropractors, exercises etc.

If you do end you being treated by them, let me know the outcome - good or bad.
I can't envision a future where they are anything but a scam. The tokens have no legal or economic connection to any business activity produced by the token creators so I don't see why any ICO token would be worth any more than any other besides hype.
This doesn't work. I've gotten many bad reviews, because people thought I was being "curt" or "mean" because I was replying to their question with short replies.

None, of my emails were intended to be mean, I just didn't see the point in fluffing up my emails, and only responded with the required information, but I guess people require the fluff or they get their feelings hurt.
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To quote Buck Turgidson in Dr. Strangelove, Well, I don't think it's quite fair to condemn the whole program because of a single slip up.

The PAC-3 is based on the SDI ERINT, a missile which itself failed several tests and then finally passed a rigged test.

https://en.wikipedia.org/wiki/Strategic_Defense_Initiative#E...
I love this. I think both of you are right, but your perspectives are for different time frames, with one side having an ideal view about a future time frame, while the other thinking about the now. This is the kind of situation that leads to innovation and how projects like Linux or neovim started. It's a natural way to progress. I hope jackpot51 gets pissed off and takes redox to the point where it proves the naysayers wrong, which will take time and effort, and doesn't serve the now.
> missed their target ... A kilometer is a pretty normal miss rate for a Scud

Assume a target of 0.1km x 0.1km, but the missile may hit anywhere in an area of 1km x 1km around the target. That means the area of the target is 1/100 the size of the overall area. They'd have to launch at least 50 Scuds to have even a 50/50 chance of hitting the target.

Can someone tell me if that calculation is way off? It sounds like this attack, other than spreading fear and panic, was very unlikely to work.
Perhaps, but on the other hand too many managers wrongly think that their organizations are unique and special snowflakes. Sometimes plain vanilla is the best flavor, and many organizations would get better results by implementing a modern methodology exactly as written rather than wasting a bunch of time customizing it.
> And if you're implying that Rust is easy to read, for a beginner, because it uses curly braces, I'm not entirely sure what to say.

Rust is easier to read because the visually natural distinction between words and punctuation has the same kind of meaning in Rust that it does in prose. Reading Haskell feels like reading a paragraph without any punctuation; there's no structure to grab onto. A lot of the time you can't tell whether something is a type parameter or a value.

Also $ is utterly alien compared to any other remotely mainstream language, . means something very different from what it usually does and what it usually means is rarely used ("subject verb object" is very rare in Haskell code), the :: type syntax is obscure, the mandatory split/duplication between function declaration and definition feels weird...
not sure if that's a viable alternative for the web. It will most likely consume more computing resources which makes it hard on mobile and the responsive web goes out of the window.
It can make sense for certain interactive elements though.
> HN is an English site mostly written in American English, do you therefore reckon its content is intended for an American audience?

Yes. The coverage and topics are heavily weighted towards companies in the Bay Area + local US events.
So, you say Python is totally missing the point and is wrong? Even when encoding videos, performance matters.

Also, that optimizing compilation is important is no reason to not work on i386. This is a point Rust needs to fix. And not only i386 support, but also other architecture families, as host.
There's lots of food for thought in your essay. There are aspects of UBI that appeal deeply to me, since I could happily spend the rest of my life reading, making music, and writing software that scratches my own itches, and I've never been very status conscious. If I think about it, most vocal UBI proponents I've been exposed to probably have a similar personality, but as you say, it's not clear that the long tail of the population operates this way.
A fast edit-compile-run cycle makes development a lot more efficient in my experience.
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Given that this article is about a regulated US exchange introducing trading for btc, I'd say chances of US outlawing it are slim. Possibly more regulation around it, but outright banning, not likely.
Can you explain why the update rate is 10 Hz? It seems orders of magnitude away from current tech, and even from tech of 20 years ago.

Perhaps I misunderstood what the update rate was, but I interpreted as the rate at which the "chaser" can update its trajectory or take action (kind of like the main loop running 10 times a second).
I'm interested in what fields you would use this methodology. Machine learning?

In most fields we have a sample of known input vectors, including edge cases, that map to known outputs. A unit test is enough to test these methods with different implementations.
There was a book I read about "are parents coddling their kids too much" and whatno, I forget the title...

They spoke about all the concepts of "hellicopter parenting", "kids being spoiled nowadays" etc. Then they go on to mention that literally every. single. generation that ever was written about since as far back as our records hold, was written about in the same way!

Yes, that's right, EVERY SINGLE GENERATION, since as far back as we have reporting, has been spoiled rotten, has no respect for elders, is entitled, and so on.
Years ago, in my high school Phsyics C class, the teacher gave us an exam which was just the process of calculating how to intercept an (IC)BM. It was a really great exam, leading you through all the steps required, and gave the answer really clearly.

It's incredibly hard. I won't repeat sibling comments about how difficult the actual interception is, but will add that you likely have seconds AT BEST for your own launch to take place. You can do guidance mid-air, but miss the window...
Thanks god my assumption was wrong.
Location: New York, US
Remote: Yes
Willing to relocate: Yes
Technologies: Python, Android, Java, Bash
Résumé/CV: https://cloud.mdefrances.co/nextcloud/index.php/s/qumKxO6mlPsKsA8
Email: midefran@outlook.com
This might be a better model:

https://www.fitnessmagazine.com/weight-loss/tips/motivation/...
I preordered the book back in September. Will I need to pay separately for the Kindle copy?
Again, a slight social hit that is completely excusable (no investor is perfect) is a far cry from losing your home, savings, car, job, etc like a middle class person would have.
She started writing shorter and more concise emails (but, alas, not shorter and more concise articles) and liked it.
"You could still see the scars of those years in his health and his relationships with his spouse and kids."

How so?
I didn't expect people to comment on the game itself... It is indeed quite simple at the moment. Maybe your opportunity to get your feet wet with Rust by improving the game logic?
Tensor networks, as in the condensed matter theory sense - i.e. matrix product states, DMRG, time evolution, many different physical systems, some different tensor network topologies etc.

Unfortunately closed-source (though open for collaborations), otherwise there’d be a link here.
It's become clear to me that a lot of the Rust fanatics don't actually know how C++ works and and Rust is their first low-level language. The ones I'm talking about know enough to make them sound like they know what they're talking about unless you actually know what they're trying and failing to accurately describe.

It sounds and seems like a language worthy of more investigation on my part, but I have to agree that the militant, presumptive attacks on any language besides their Chosen One has left a bad taste in my mouth.
One day only about 1 bitcoin (worth 1 trillion) will be actually tradable. Everyone else will be holding.
Racial discrimination may play a role, but it does not explain the discrepancies in crime rates that we see: https://www.channel4.com/news/factcheck/factcheck-black-amer...

I'm not saying that black people commit more crime because they're black. In fact, that's exactly the point I was trying to make: blaming black crime on their skin color is bad because it ignores the socioeconomic forces causing them to commit more crimes than other races with lower poverty levels. Just like how blaming boomers ignores the geopolitical and economic forces that gave them an advantage at the time. Not all black people commit crime, and not all boomers were privileged or lucky in life.
Some more checks done:
- Roadmap: check

They're missing the Whitepaper and Telegram group though. I assume the later would be used to pump the ICO.
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While technically true, in practice GHC is Haskell is GHC, and so the GHC runtime is "the Haskell runtime".

I think the energy that used to go into alternate Haskell runtimes is now going into alternate languages, like PureScript.
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GeneralizedNewtypeDeriving and DeriveAnyClass (although this is fixed in 8.2)
Project management is more of a pyramid than a triangle: risk is the fourth variable. There are sometimes circumstances where you do well on the other three variables by accepting a high risk of outright failure, for example by adopting an untried new technology.
This is sort of beside the point, but I wanted to point out how great a piece of journalism this is. The integration of maps, video, and pictures is exactly what old print-media organizations can provide online and take advantage of. This is a really compelling narrative that shows real, honest reporting. That's worth noting.
Preprint at https://arxiv.org/abs/1705.07621
I find most of the programming/lang/framework subreddits intolerable. I dip into those waters occasionally, but unsub pretty quick. Too many egos, trolls, asshats, and too much noise. There are notable exceptions, like /r/elixir. But I abandoned /r/python and /r/django months ago, and won't be back. I'm an adult, and prefer to discuss things those who will show at least a modicum of respect to others.
Show HN: Truck.app: an SSH browser with rsync
no, it is cash settled only
There is always cone on uncertainty around the missile position and speed and interceptor position and speed.

Both the missile and interceptor must meet at the same place at the same time. The time window decreases with speed, so timing is everything.

Faster the incoming missile, harder it is to intercept. If the speed delta between incoming missile and interceptor is to high, interceptor can't correct it's course fast enough to hit the missile. Interceptor has inertia and it's deflectors or thrust vectoring can correct it's course only so fast.

Interceptor positioning on the ground is also important.
On some level it's a statistics game. Even in the absence of a defense system X/Y missiles will hit the target depending on the details. A defense system reduces that number further.

Better to get the system refined when the stakes are low. When the Houthis miss the airport and they're a lot more likely to hit sand than city. When NK misses some city in SK (not necessarily Seoul because they can hit that with conventional artillery) they're much more likely to hit something we don't want them to hit. Now, the latter situation may not be relevant within the lifetime of this system but having the system be "battle tested" serves to make it even less likely.

This sort of scaled to all defensive and deterrent systems. The more successful they are the more the generals in the war room will say "We can't just do $offensive_thing because it's not likely enough to be effective in the face of $defensive_thing"
> ... crypto-nutcases view of the world ...

I'd suggest that discussing your point without the ad hominems makes for a stronger argument.
Location: boulder, USA
Remote: Yes
Willing to relocate: possible
Technologies: python/ javascript/ objective c
Resume: Location:
Remote:
Willing to relocate:
Technologies:
Résumé/CV: https://docs.google.com/document/d/1Qn11IeoCK8HLYPTBapzMEJuJ...
Email: sam.barranco@gmail.com
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I guess the GP is a fan of abstracts.
Which should make it easier to convince MPs to change things, a little thing like showing all of their dirty linen to the public. Though being a US citizen, all of this is coming here soon as well.
When goods and services start being quoted in BTC you would have that argument.
If compilation of rustc runs out of memory it represent an upper limit on the complexity of actually viable Rust programs, and given how much software is larger than a compiler it is a discouraging performance level.
The difference between your situations is probably meaningful because industry perceives CS students and self-taught web developers differently when it comes to entry level jobs. For example entry level jobs at places with Glass Door reviews are far more open to the CS student than a self taught web developer. A self taught web developer is more likely to land an opportunity in a local web-shop than at a big company or a startup. For the self taught web developer, applying for a first entry level job at Google or Apple or Uber or Github is a waste of time.

CS students tend to get a pass when it comes to the problem of finding great developers. [1] Self taught web developers tend not to.

[1]: https://www.joelonsoftware.com/2006/09/06/finding-great-deve...
Show HN: Augmented Reality Smart Kitchen
The chance of a hit is even lower: 1 - (0.99^50) ~= 40%
Yes, Scuds go Mach 5 (3800 mph) which is indeed stupid fast. That Patriot PAC-3 only goes Mach 4.1 but then it's not chasing its target down.
Bosses are under increasing pressure to take stances on social issues
Ah, so what non-millionaires like me are doing wrong is we're not starting a bitcoin ETF. I'll have to start one in the spare time between my two jobs. Meritocracy!
Wow. What would be the possible reason for blocking incognito?

You still get the full ad experience? I can't support any company that is demanding that they not only serve their ads but also be allowed to track the visitor after.
> Nobody cares about the security implications.

Assuming he's innocent for a moment, I'm going to bet Damian Green cares...
Yeah, I think I will add the terminal emulator in the question

Edit: changed my mind, will just let it about beauty & artistic appearance, not app features
uBlock Origin works fine for me, but blocking incognito mode is next-level skullduggery. I hope these guys fail.
Thanks for the response. I just googled "canada pronoun hate speech" and felt lucky, that is picked the first response. The situation appears more nuanced. Third link: https://politics.stackexchange.com/questions/20038/why-is-ca....

The fundamental issue with the "ever expanding slur list" remains, until we all speak the language certified by the party bureaucracy.
> why would I spend this currency on _anything_, including other investments, if holding onto it is the best investment out there?

Different people value different things differently, thus there is no universal agreement on what the “best investment” is. Remember that the price of Bitcoin cannot change without both a seller and a buyer. Each bitcoin bought is a bitcoin sold. The most obvious and simplistic example of a reason people might sell Bitcoins right now is that they are hungry and want food, but that generalizes to more complex differences between individuals’ time discount functions.
> Programmers love language wars

Programming Language Advocates love language wars

Most programmers just like to be aware of ALL the PROs and CONs of the languages and choose the right one for the task at hand.
Lead developer here! I enjoyed exploring how a projector-camera (pro-cam) system can create great hands-free augmented reality, and I wanted to share the project for any interest and feedback on the project.

Please reach out to my email if you want to learn more aem336@cornell.edu
> My impression of Haskell is that the main issue is that laziness is simply wrong, since it causes space leaks that are hard to reason about, and seems generally less efficient than eagerness; furthermore, it seems rarely beneficial, so it seems more appropriate to explicitly request laziness rather than the opposite.

Agreed; Idris is strict by default and I expect other post-Haskell languages will be too.

> The next problem is that complete immutability is also wrong, because controlled mutable aliasing with linear types (like the system available in Rust) is what you really want since it's more general, efficient and expressive (allows mutable data structures), and complete immutability is just a special case of controlled mutable aliasing.

Disagree. Mutability is so rarely what you want that it's better to have immutability by default, and a clunkier syntax for mutable is ok.

> The third problem of Haskell is the weird syntax, that doesn't follow the common C/Java/JS or Python syntaxes for no good reason, making it hard to read and learn the language.

Yes and no. Curried-by-default is the source of a lot of Haskell's power, and that requires a certain amount of unusual ordering. The terseness of pointfree style is worth some learning time. $ is a big ergonomic advantage, though I'm not entirely convinced it's worth the cost. There are a few cheap wins, some of which Idris has (e.g. single colon for type annotations, standardised syntax highlighting) but you don't want to throw away the good stuff.

> And if one were to change these things in Haskell, the result would essentially be Rust (or more precisely, a future version of Rust once all the missing abstractions like HKT, specialization, etc. are added), so I think that's what one should use instead.

Agreed, but that thing doesn't exist yet, and the Rust that exists today isn't an acceptable substitute (it's 2017, I shouldn't have to use a language without HKT). For the moment I'd say Idris is as close as you can get.
If millennial people are unhappy, unhappy people are millenials.
YouTube Randomly Translating Titles and Descriptions?
There are no goods and services inside your model.

There are only 2 currencies. Your assertion that the exchange rate is bogus because it is possible to buy 1 BTC for $400 applies just as well in the opposite direction.
I just bought one, used, on eBay last month. I'm pleased with it, although the keyboard action is very stiff -- and I speak as an IBM Model M fan.

As a modern version, some kind of enclosure for a Raspberry Pi would seem the obvious answer. Then all it needs is a text-only Linux distro -- easy enough -- and a decent editor with a modern standard UI, such as TextGrinder or Tilde.

ErgoEmacs with a facelift and modernisation might do, but not without it. Ditto Vi. Seen the joke?

"I've been using Vi for a couple of years now. Mostly because I can't work out how to exit."
This is actually the APL way. You make the language so high level and dense that even complex methods are one-liners. When you need to update it, you rewrite it. APL people have been screaming this for years.
> and if there are biometric sensors that make
> sharing login information impossible (but that
> would annoy people more, not help them).

Just add 2-factor-authentication tied to their phone. You can use Google Authenticator (RFC 6238).
How old is “too old” to be an entrepreneur?
Black lives matter? Science demands action? NoDAPL? Womens March?
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