skysight-inc/HackerNews huggingface dataset:
It's curious, the hard 'scientific' challenge is finding the N6 antibody sequence. That code/blueprint produces the atomically-precise nanomachine that is capable of neutralizing HIV. That work is done. Here it is:

>RAHLVQSGTAMKKPGASVRVSCQTSGYTFTAHILFWFRQAPGRGLEWVGWIKPQYGAVNFGGGFRDRVTLTRDVYREIAYMDIRGLKPDDTAVYYCARDRSYGDSSWALDAWGQGTTVVVSA [1] [2]

Yet the current, engineering-style challenge is getting that protein sequence expressed in the right place, at the right time, without disturbing its environment, etc.

It's hard to compare the difficulty or danger of trying a therapy with 'scientific' risks versus 'engineering' risks. At first glance it might appear that now that the scientific problem has been solved (to a particular extent), that the engineering challenge is easy. However, the details really do matter. And not having all the facts, can in fact be lethal. On the other hand, to some extent, the scientific challenge really is the limiting capability, whereas the engineering challenge could be considered one of degree and risk. One this guy, for better or worse, was willing to take.

[1] https://www.ncbi.nlm.nih.gov/protein/1079417984

[2] http://www.cell.com/immunity/fulltext/S1074-7613(16)30438-1
> I have more choices for an ISP than I have choices for a cell phone OS.

That's lovely for you, but here's the whole picture: In the latest FCC Internet Access Services report, 13% of census blocks with housing units (that is, empty census blocks are not considered) have three or more broadband providers. 37% percent have only one option, and 21% have no provider at all. Having a choice is not the norm.

https://apps.fcc.gov/edocs_public/attachmatch/DOC-344499A1.p...
In other words, doctors salaries are so extreme because it saves the state government a few bucks when training doctors.

This is pretty common knowledge among doctors of course, who starting at least a decade ago, have started clamoring for more and cheaper places in education programs. These it's tough finding any doctors at all who aren't asking for more doctors in training.

But systematic decisions to defund education, starting a long time ago (like 30 years ago or so) and have continued under every government since. That is the root cause here.
Are you sure it's not just a case of Hollywood style accounting?
Yes some drop out and residency positions go unfilled, but please see Figure 1!

http://www.nrmp.org/wp-content/uploads/2017/06/Main-Match-Re...
Do you want your system to kernel panic every time the security code gets a false positive about a problem? The security code is just as likely to have bugs as the software it is securing.
The Transformer is dead i can't believe it
> Much of what we choose to spend money on is stuff that we as Americans seem to value. Much of that value, unfortunately, isn’t all it’s cracked up to be.

This speaks volumes, far beyond just the healthcare system too.
Good comment. One disagreement I have is the implicit dichotomy that it's either the doctors or the insurance companies who are soaking the patients/consumers, and not both.

Both the MDs and the insurance companies are rife with a number of rotten incentives and bad actors that contribute to expensive medical care without quality commensurate with costs.

In fact, the entire policy debate over risk-based vs fee-for-service payment models is essentially the payers and providers arguing over who gets to rip you off.
Interesting. I never had that problem. Some people can't tell the time in the 'other' system, but they always recognised that it's a system they don't know.
Amen to this. Like every other government regulation, government interference in the medical field simply limits competition and protects entrenched interests, it does not keep people safe (and that is not the real intention.)
That's how Tinnitus Retraining Therapy works, but there's also a physical component that makes it more likely. Researchers have hypothesized that if you have sharp notches in your hearing thresholds at certain frequencies, your brain is more likely to try to fill in with tinnitus than if you had a flatter loss across the spectrum. As the article states, this is still an active research area -- we don't really have a comprehensive understanding of the mechanisms that create tinnitus yet.
Altman is peanuts in terms of influence compared to Zuck and Thiel
I think you missed my point. I’m not saying psychologists should prescribe meds. I’m saying that medicating psychological problems should not be done in the absence of an appropriate diagnosis of those problems. This can be done only by a psychiatrist or psychologist (edit: and most psychiatrists aren’t trained in testing either, and will generally refer you to a testing psychologist if they think your problems are complex in nature). GPs and NPs do not have appropriate training in diagnosis.
Going against the popular opinion.

Sure, but when the salaries are too low like they are in Southeastern Europe doctors don't want to schedule surgeries($500+), do a proper look-up ($50-100) or even bother to check on you or when an inadequate doctor/nurse/practitioner checks on you or does a procedure and screws up what happens? Nothing. Tough luck pal. Healthcare is public, you're required to pay for it and it's deducted from your salary. What do you get in return?

Two nights ago I brought my girlfriend's sister to the ER, her appendix was inflamed, she couldn't walk, talk or move due to pain and was left waiting for an hour. They did blood work and gave her an IV and sent her home, told her "we cured you" after another blood work was completed and her leukocytes dropped a bit. No ultrasound, ct or anything advanced, they haven't even properly checked her stomach. Her leukocytes were >19000.

I was later told by a friend that I need to give a 50 to the nurse to push her through the line and another 100 to the doctor. Great world we live in.

Don't get me wrong, but I think you should not fix something that is not completely broken. Your doctors still do their work and don't expect money, expensive gifts, bottles of whiskey and roasted pigs like they do in my home country.

In my country number of doctors you're allowed to have in a Clinic/ER/Urgent Care is proportional to the number of people living in the region. There is 1.3 gynecologist on a region of 10,000 people. Is that normal? My grandmother has to schedule a month and a half in advance to get her prescription medication and check ups are every two-three months. Not sure how it is in the States now, but in my 10 year tenure there and 10 times I was in the hospital, I never waited for more than 10-15 minutes after my scheduled time.
Sure but people still have bodily autonomy. Nobody has the right over anyone's body. You can tell them the risks, you can try to convince them to get rehab, but they ultimately have the right to do what they want with their body. Whether or not you disagree with someone's right is irrelevant, it's still one of their inalienable human rights.
Restricting access to medical education (certification) is only one way to restrict supply.

Another way is to require certification for more kinds of activities in the first place.

If Americans want access to less expensive healthcare, why not make it so that some kinds of medical treatment are available from people with ~2 years of education instead of 10? (Yes, the treatment would be inferior, but also much less expensive.)

Also, when IBM's Watson becomes the world's best diagnostician (Any Day Now), what will its legal status be? Probably IBM would be happy with a special exception to the law that makes it hard for other computer companies to enter the market?
Is Google's Nest home automation system a worldwide failure?
Importantly, the costs of our medical system relative to other systems will never be fixed until we fix this problem. But this is the hardest problem to fix, because nobody wants to talk about it. It's political suicide.
It would probably kill open source in the US and put us in a competitive disadvantage globally.
' “I remember I was very happy to be a bride. I wa,” Khan said
> Are you sure it's not just a case of Hollywood style accounting?

Yes, for the reason I said:

> An easy way to reason about this is to remember that nothing's stopping hospitals from opening up residency slots that they self-fund. If residency programs predictably broke even, you'd expect them to do that. Except, almost no hospital does this, because the programs don't predictably break even - in fact, they pretty predictably lose money.

Even if you don't trust the accounting numbers, you have to trust the overall (lack of) incentive for hospitals to create self-funded programs.
Well the alternate is capacity. They only have so many doctors on staff to supervise which limits the slots. Think of it as a management problem.
I'm pretty sure that marketing is the purpose of their secrecy.
If you want to reduce doctor salaries, then you need to reduce the exclusivity of their skillset. You need to reduce their working hours, their student loans, and you need to automate the detection of issues/mistakes.

Their hours need to be limited to sane levels. Medical schools need to get cheaper. Robots, IoT health and fitness devices, and nurses need to take over more functions that Doctors perform.
I agree. The first thing I did when I heard about the limitations was question Facebook's intentions there.

I think their walled-garden approach, if it received an overwhelmingly positive or at least unquestioned reception, would have set an even more dangerous precedent.

Governments don't (AFAIK) set up internet services as social welfare for the poor in other countries. Facebook doesn't have any borders. Unless they're actively told to keep their rabid growth in check, they will just keep going.

Nothing directly against Facebook here, but I definitely think it's better that the poor and uneducated throughout the world are not normalized into a Facebook(TM) world of knowledge. We've seen what's happened with a much milder and more open situation in the United States (and elsewhere) quite recently.
Good question, and worth investigation. While you do, please keep in mind that employers are not monolithic, but made up of lots of different humans with their own agendas. (And lots of those agendas include the objective of "cover your ass".)
Looks like Reason is drinking the Kool Aid.
No. Just looked, and the only large file generated is the dependency cache (~7000 lines of json) which you never touch and can always be regenerated with dotnet restore.

The rest is ~100-150 lines code+configuration and a readme file (~180 lines).
If you still want to use a Git repo, at least use an encrypted Keybase teams repo[0].

[0]: https://keybase.io/blog/encrypted-git-for-everyone
I can confirm that on a coworker's MacBook 12,1 running ArchLinux mei-amt-check[0] reports no AMT.

I'd rather have a more thorough ME test than just AMT I could run though, coupled with a statement from Apple that ME is or will be entirely neutered on Macs in the future.

[0] https://github.com/mjg59/mei-amt-check
It will be interesting to see how well the HomePod will integrate with other devices.

It will most likely integrate perfectly and seamlessly with other Apple devices, and maybe not so much with other manufacturers.

I have fiddled some with home automation and unfortunately, working with Apple products has been a miserable experience.

Really? They are generally considered to be the UX/UI standard and have, arguably, built their entire company on optimizing these two things.

If it takes Apple this long to ship a smart speaker, how do they think to keep up with integrating (or producing their own proprietary) building blocks for the smart home vertical?

Apple generally releases products with a more narrow scope, and then iterates on those products. This has been their general approach, and it seems to be working well for them.

If their devices on the smart home vertical continue to be as closed as the Apple TV, people will be completely locked-in Apple's ability to produce new devices, which certainly hasn't seem to be in their recent past interest.

People have been "locked in" into their services and devices for years now, yet they keep coming back.

I just think Apple's take as of now is a lost cause if they seek to dominate the space with the same sort of walled-garden approach

Every single reasonable business metric (stock price, sales, growth, etc.) would indicate that you are wrong and those folks in Cupertino must be doing something right, but hey I guess this could be the thing that dooms Apple to mediocrity.
I’ve been repeatedly denied by gatekeepers disinclined to let me inside

They say stay at the perimeter. Keep to the outer limits. They’re the ultimate limiters. Competitors can’t get in it.

If we can’t even begin, they keep taking the win. We stay thin like we’ve been. They keep raking it in.

Good luck plucking a chicken or an egg from nothing. Success flows to success, and so far I hear no clucking.

I’ve jumped through enough hoops in my lifetime. More exclusion? No thank you. If we take cues from anyone, let it be tradespeople, e.g. apprenticeships.
It’s relevance is in how clearly it illustrates the ease of being able to correlate two unrelated things, but despite this fact many people repeatedly try to use correlation to imply causation.
My son is 6 now, and he has loved these two books since he was about 3:

The Boy Who Loved Math: The Improbable Life of Paul Erdos
- https://www.amazon.com/Boy-Who-Loved-Math-Improbable/dp/1596...

Bedtime Math: A Fun Excuse to Stay Up Late
- https://www.amazon.com/Bedtime-Math-Excuse-Stay-Late/dp/1250...

We also started this book recently, and he has really enjoyed it so far:

Women in Science: 50 Fearless Pioneers Who Changed the World
- https://www.amazon.com/Women-Science-Fearless-Pioneers-Chang...
Sure but the real risk here is normalizing self administered gene-therapy. When people read about it in the BBC they will naively assume its safer than it actually is. This opens the market to layperson when in reality we should be guarding against this stuff until its further along.
It probably self perpetuates b/c the AMA and doctor lobby have enough excess money to buy out members of Congress.
Unless you have a horrible incurable disease, you have absolutely no right to comment like this. You have no idea what it is like to live like that. People with such diseases are often on the verge of suicide anyway - you are unlikely to be able to put yourself in their position sufficiently to be able to judge their choices.
Though if NoScript is any indication, they will not work as well and the user interfaces will be inferior.
I have produced thousands of reports in excel format in the financial services industry. If there were an easier api to just have an excel sheet pull/push data from/to a web service, this would be the best of both worlds.

The interface is very familiar for many professionals, its just a matter of coordinating and working off a the same data.
Henceforth known as "jasode's corollary."
Send a message through a safe, private and encrypted link that auto expires
In the age of the IME and the hundreds of billions of dollars the US spends on US covert operations. I'll let you guess what the path of least resistance is.
Regulations may slow down innovation, but they also protect against companies who try to socialize the externalities of their business activities.

To me, full laissez-faire capitalism is a lot scarier than a system in which everything is overburdened with regulations.
There's a long queue of people around the globe who would be eager to move to the US to participate in the American labour market, if they could. So labour shortages are easy to solve, if there's political will.
The new American Dream. Get to C-suite as quickly as possible, offshore as much as possible. Even if none of your "strategic" read consultancy driven plans work out, ka-ching! F-U money for life.
Right, but the BBC wouldn't dare run an article about squirrel suits without talking about how dangerous they actually are. In this case they should have done the same thing. I'm all for people experimenting on their own bodies, but when we talk about what they're doing we better portray the magnitude of the risks they're dealing with.
If the ear doctor you saw couldn't diagnose the problem, you might want to look for an otologist or neurotologist. It's a more specialized version of an ENT that deals with problems of the inner ear.
Macros have their problems, but automated code generation is almost always worse.

In any case, I would like to point out that there are other answers to the problem than macros. For example, Haskell has lazy evaluation, currying and strong type system, and many use cases for macros can be implemented just as ordinary functions.
> Even the medicaid/medicare procedures are reimbursable.

Medicare reimburses rates below-cost. About 7% below COGS, which means they lose money per-patient, even before they have to pay doctors, nurses, janitorial staff, etc.

> Or you know, hospitals with residency programs could just use of the massive insurance money they make to fund residency positions.

The "massive insurance money" is used to subsidize the losses that hospitals make on Medicare patients.

> It's not like the residents aren't employees or something

Great point. And that's why companies generally don't hire employees unless they work they do is profitable for the company. As it turns out, residents are not profitable for hospitals, which is why hospitals don't "just hire more of them".
> where they're not as worried about global competition

Because, in general, it's difficult for 99% of customers to drive to another part of the world for care. It does happen, of course, for those with such resources.

> have strong professional organizations who not only set competence standards and control labor supply

That decide who can and can't create simple REST apps and games? That charge huge amounts for certificates that they've lobbied be required even though they'll be universally panned as useless?

> lobby the government to mitigate competition and legislate who-can-do-what, with results very friendly to M.Ds

So, yes. Ban out everyone that was self taught. Or went to the wrong schools. Or in the wrong country. Build huge walls around who is allowed to learn the mysteries of the machines sitting on most desks and in most pockets so that a chosen few can become rich at the expense of all those locked out

> stark contrast to the free-for-all race-to-the-bottom that characterizes tech labor

Goodness forbid you be required to be more useful than other people in order to make a living. It would be a better world, surely, if you could just get your stamp of approval and be set for life, knowing people had no choice but to choose you

I see constant need for developers everywhere. We cannot hope to create all of the programs that need writing right now, and you want to cut out a huge segment of developers for being distasteful in order to pad your pockets.

Don't forget to make users get licensed to use Access and Excel et al while you're at it. Those are pretty program-y applications.
Wrong, worst case scenario isn't that he just kills himself. The worst case scenario is someone else points to this story as justification to sell their off-the-shelf gene therapy kit and thousands of naive people die as the result.
Did they actually drop? From what I remember, illegal migration has been dropping for years now.
Saying — based on evidence — that somebody is stupid isn’t an ad hominem. At worst it’s shorthand for “his actions are stupid”.

Which, given the evidence, they unarguably are: Virtually every expert in the field, as well as other biohackers, think that what he’s doing is a bad idea, and based on dangerous superficial knowledge. The comparison to Barry Marshall (the stomach ulcher guy) is particularly unhelpful since Marshall was an expert in the field, and acting on a solid theory and with a contingency plan. But even his actions are still rightly called reckless.

All that said, I’m still impressed with Roberts’ self-experiment, and curious about the results of the long-term follow-up. But it is stupid.
Are you fucking serious? Say Verizon strikes up a deal with Huffington Post / MSNBC or Fox and Breitbart ... (The one you're less politically aligned with)..

Now you can get wonky news from a source you don't trust for Free because it's 'included' in your package OR you can pay an extra $10 per month to get the other sites, and you may need to pay $5 per site that you want to visit.. Paywall nightmare.

But the worst is-- now Verizon has full control of your political beliefs because they're ONLY allowing you to view specific content UNLESS you pay. THAT IS CENSORSHIP!

This is not a good thing.
For low frequency sounds, earplugs make it worse - they reduce higher frequency sounds much much more than they reduce the vlf sounds. The result is a more acute awareness of the annoying low freq sound.

But hey, if it works for you, great!
Main issue is enforcement. Engineering is a good example. Engineers become licensed have guilds etc. Thing is they tend to work on things that are in the physical world and if they break they will cause death and destruction. So the government will force a company to have an engineer stamp that this design doesn't suck and hold them liable when it does. More importantly, most infrastructure projects engineers work on tend to have government involvement to begin with meaning that someone with power to enforce the law will decide that it is appropriate to work with a licensed engineering firm. This becomes much more challenging at a typical software shop that is working on some run of the mill web app that won't really impact anyone's life adversely if things go wrong and generally have an opt in mechanism to begin with (i.e. Facebook or Google). I'd say where it would be very very useful is making it so that license software engineers are the one's who sign off on something like Equifax to prevent security breaches, or basically any software that impacts someone's life directly and can't be reasonably avoided (think banking software, medical software etc.)
Marketing consultant, nyc, 300k a year
> The fact that residents aren't paid much by the hospitals doesn't mean that the hospitals aren't making a net profit,

No, the fact that hospitals don't just hire more residents is what demonstrates that it's not profitable for hospitals to simply hire more residents.
Deploying an SPA as a Go Binary Using Webpack and Statik
Woo Launches Virtual Headhunter for HR, Job Candidates
There are plenty of reasons to eschew short term profitability for long term profitability and prevent flooding the market. Fwiw my information is gleaned from "An American Sickness" where the Harvard MD writer claims that a resident costs something like 180k but makes the hospital 300k.

If it is the case that the author has intentionally neglected to mention other factors that contribute to a resident being a cost center, I would sincerely be interested to learn about this.
That's why it's going to take automation to finally drive disruption in health care.
At my company (mostly a Windows and Microsoft shop), my domain credentials are used to log into the VPN, and TFS, and Octopus. Compromising just that one set of credentials could effectively "own" our company. And I'm just a senior-ish developer.

Lateral movement by an attacker is a real thing. And while credential reuse is something most security focused web companies are trying to mitigate, a push for "sso"-like account management is seemingly undoing most of that effort inside the network if not done properly (specifically, auditing and monitoring of behavior).
And now let's look at the size of US drug market and it's 4.6x the size of estimated salaries from the article. Almost looks like article was sponsored by Big Pharma
It's not a strawman, the amount of resources X required to deliver at least Y bits per second is not a linear relationship.