skysight-inc/HackerNews huggingface dataset:
For stop codons to be relevant the first step would have to be to transcribe the synthetic DNA into RNA, which would require the presence of adequate promoter sequences. Given their complexity and spacing, this would already be quite unlikely — so most of that DNA would never produce RNA. But actual gene expression isn’t the only side-effect of introducing random sequences (although it would be by far the most severe): The synthetic sequences might also contain spurious regulatory motifs, or destroy the spacing of existing regulatory regions (not to mention that altogether random insertions would potentially destroy existing coding sequences).

At any rate, this is all purely academic since it makes very little sense to inject synthetic data DNA in living cells: Living cells have a very xenophobic attitude towards foreign DNA (as they see it as potentially viral) and try to destroy it. Once that’s solved, the synthetic data DNA now sits in a cell. Wet, and full of enzymes. These are actually not very good conditions for DNA molecules to persist. Cells age and die, and fragment their own DNA in the process. Or if they don’t, they copy the DNA and, while doing so, introduce errors.

No; DNA as a storage medium for data makes most sense when it is dried up and frozen. Better yet, vitrified (but so far there’s no way of undoing DNA vitrification without damaging it.
What sites were you watching video on? I found the h264ify plugin to make a huge difference in performance and battery life watching YouTube in Firefox. I think non accelerated codecs get used otherwise.
Indeed. I actually mentioned this before they ever mentioned "Project Quamtum" (last year), that if they ever plan on releasing a major overhaul of Firefox based on components written in Rust, it also needs to come with a new look as well as new branding. Otherwise, most people wouldn't perceive what's really new about the new release, even if it's indeed faster, more secure, etc.

This is what Microsoft also did with Edge and at least from a branding point of view, it worked quite well for them, because people do believe it's a new start from Internet Explorer. It's just that many didn't think that this new fresh start was better than Chrome for the most part (the fact that even now it only works with 70 extensions is a big reason for that belief, too).

I think Project Quantum hit the right spots for the most part. Headlines didn't just mention "Firefox 57" but "Firefox Quantum edition."

Hopefully the Mozilla team is writing down all of the things that worked well for them this time around (as a tactic checklist) so that they can repeat them for future major releases, too.
That was indeed EA, they do this type of matchmaking in FIFA.
You fork bitcoin into a local currency. It might be some time before the world is back online anyway.
You haven't answer the core question, which is: Why can London do this, while NYC cannot? Is there less red tape with accountability in London?
I think the reasons for "Facebooks fake news problem" even being a story are two-fold: elites in the corporate "journalism" cabal understand that its a great distraction from the important discussion of data retention. & it also helps to shift the blame away from Hillary's party for losing the election because of a terribly run campaign.

Call it a conspiracy theory. I really don't see the actual cause being, primarily, anything other than those.
I almost always buy textbooks through alibris. Thier prices are typically much lower than Amazon for used books. Sometimes I have to purchase an international or the next newest edition, but I almost always get out for less than $30. I actually just bought "the dragon book" 2nd edition for $25 shipped.
15 Proven Ways to Increase Creativity That Simply Work Pt.3
What you did was not vandalism, but it was rude, since it violated the moral right of the other user to control the words associated with their authorship. When one contributes to the article space, one is explicitly relinquishing that right, because Wikipedia is a collective effort, but that does not hold for talk space content, particularly when it is signed.

And what you did was doubly rude because you acknowledge that your version was "preferable"; that is, it is conceivable that the other user prefers their version. They may be wrong to do so, but by editing their words directly you are denying them their right to an opinion. It is not surprising at all that your edit was reverted.
No, the Roman culture always considered themselves in a state of decline compared to the mythical "golden age", so that would be the mainstream viewpoint.
Judging from post-WW2 germany, cigarettes were the most valuable thing on the market.

Probably because Alcohol and Food can be fairly easily self made (germany, tradition of beer brewing, you'll find someone, also lots of farmes, even today)

On the other hand, tabacco is from overseas and requires some difficult manufacturing. Same for bullets, mostly.

I think alcohol and food would stay cheap. The things that would replace money are things you absolutely need but are hard to produce without modern civilation. Ie, cigarettes, bullets, gasoline, rifles and toilet paper.
Ask HN: Resources on how to improve abstract thinking skills?
If Syria has taught is anything I hope it is that Hobbes is right -- however bad you think your current government is, civil war or revolution is worse.
It's downright embarrassing to walk through a Redux-using project with someone competent who's not immersed in the JS world. Source: had to do this recently. It helps if you translate "action creator", "action", and "reducer" to terms that are less misleading in the first two cases, and less uselessly-generic in the last one, but only a little.

I tolerate it for basically "no-one got fired for buying IBM" reasons, i.e. the devs I work with think it's good and it's better to have twice as many problems and none of them be my fault than half as many and all of them be my fault.
It could be good for me. We ($work) have some embedded devices running BusyBox that we only have limited (i.e. non-root) access to. I'm looking forward for a way to escalate privileges on these devices as a result of this!
:CueCat this device allowed you to open up a link from a magazine or newspaper without typing it, truly a timesaver! I can't figure out why everyone wasn't using these. Also had a really cute form factor.
I guess using chum is better than just having a big "If you're stupid and have disposable income, click me!" link.
The world's best subway by many measures is the MTR in Hong Kong. Not only is it entirely privately run but it turns a profit which they then take to build more lines. The MTR Corporation is also building London's new 73 mile Crossrail line which opens up next year after being under construction for less than 10 years. 13 Miles of Crossrail is in underground tunnels beneath the densest part of the city. In terms a New Yorker would understand, this project is like if the entire length of the 2nd avenue subway in Manhattan got built along with extensions into the Bronx and Brooklyn in 10 years and under budget.

I can't see NY selling off their subway to a private entity anytime soon but what if a Mayor allowed MTR or another corporation to come in and build a competing line in some part of the city? The amazingly efficient new line might light a fire under the ass of the broader NYC subway to start operating more efficiently. Or as the new line begins to make more profit it could buy NYC lines one by one until it's running most of it. This way the debt bomb of the MTA won't destroy the city because it won't affect all major transit lines.
You need a better system in place to prevent bugs from happening.

- Separation between development / staging / production environments.

- Integration tests.

- Service / System Metrics.

- Central logging.

- High availability.

- Alerts.

When you have a solid deployment pipeline things don't usually break. Errors and regressions are caught in the staging part of the deployment pipeline and errors in production can be rolled back automatically (and then you add a integration test for the regression!)

All this devopsy work at my company is done by software engineers with advise from systems engineers.
And we do it because neither of the groups want to get called in the weekends :) it has been working really well. Last year we had 0 calls. Before we had this in place things would break in a weekly basis.

You can build all of what I mentioned with OSS like:

- Ansible (deployment)

- Jenkins (ci)

- ELK stack (metrics / logging)

- Zabbix (system metrics)

This system has been serving us, on premises, without much maintenance.
More or less continuous increase in demand along with constant supply.
Muchnick deserves a second edition. He’s retired but someone should take on the task.
Honestly, if society actually collapses, the only things you need in your bag are guns and ammo. With enough of those, everything else becomes free.
I have these in my zshrc

btc='echo "Btc(usd): $"$(curl -sL https://api.coinmarketcap.com/v1/ticker/bitcoin/ | jq ".[0].price_usd" | cut -d\" -f2 )'

eth='echo "Eth(usd): $"$(curl -sL https://api.coinmarketcap.com/v1/ticker/ethereum/ | jq ".[0].price_usd" | cut -d\" -f2 )'
But has Bitcoin been run over LRRF before? And in a sustainable manner?

And why would anyone actually bother when they can just use something that doesn't require power to spend? Especially considering that international trade would be toast anyway.
I can't really pinpoint it, but somehow C# dosen't seem so cumbersome as Java. Perhaps it's the libraries.
Like the explanation a lot. Even when you've understood redux, and want to use, the amount of upfront boilerplate can be a turn off. I liked this approach of parsing out the boilerplate piece by piece.
Many, many good things come from re-invention in our world. I only wish there were a longer-term awareness .. because there is a devolutionary angle, where people sort of forget why its important to do/not-do things certain ways, and end up leading us all into the abyss; cf- encryption, video games, internet, etc.
Yes I trust more computer calculations than humans, way more.
It will take a while, but It will happen.
Anyway, I think there will be better ways to transport than trucks and cars.
Wow, spam works. No wonder it’s so popular. /s
I didn't call for the infrastructure company to be split up along state lines, just the company doing the equivalent of being the Mastodon admins for a given state's instance. So, at least in the beginning, no new data centers need to be constructed. Because the API is publicly published, new companies may spring up to sell their own implementations of the FacebookInfrastructure API, and existing infrastructure businesses (AWS, GCE, OpenShift, etc.) may decide to write their own implementations as well, which provides more competition.

Both states have the power the block - the state hosting the post may block the post from being posted on it's instance, and the state accessing the post may block the post from being seen. Again, because the API is publicly available, oppressive outcomes will probably result in competing solutions implementing the federated API and adopting more liberal administration.
When you ssh to your device are you not running Busybox shell on the device? I don't understand why this is less of a problem?
Yeah, and very few brown children end up being in that 900, wonder how that is?
What about Florida, Georgia, Louisiana? Humidity doesn't seem to be an issue with homes there. How is Japan any different?
That ship sailed many years ago.

Public authorities are quasi-government entities controlled by the the bond covenants. You have to line-up the interests of the bond holders with whomever controls the authority and is desiring change.

With something as broad in scope and rich as MTA is such a deep well of political capital, it's incredibly unlikely that anyone would give up any control. It's such a large enterprise there probably isn't one roomful of people who actually understand how the organization works. The current situation was created when the whole NYC transit system was completely insolvent back in the bad old days!

Read "The Power Broker" by Robert Caro. It will open your eyes to why things are the way they are.
The new Quantum is super fast for browsing in general, but I've found some snags with some videos. Not sure if I just need some sort of plugin to make it work, but at this point I'm back to Chrome.
Very interesting! Can you talk a little bit about the reliability of your data?
There's a gradle plugin for that:

https://github.com/ADTRAN/gradle-scala-multiversion-plugin

https://www.youtube.com/watch?v=_U816K3xFz8
> You do not need monads everywhere. Once you have a hammer, every problem looks like a nail. Monads are as ad hoc as any other solution listed there: that is, not ad hoc at all.

Clearly they're not ad-hoc, since they can be used for all of those examples and more, whereas each of the ad-hoc solutions has to be implemented separately as a language-level feature.

> A generalized solution (shoving monads everywhere) may as well be much worse than a specific solution to a specific problem.

I think this is true in the small. Of course a dedicated syntax like async/await is going to be better suited to that specific problem than reusing a general-purpose solution like do notation. But once you're working on a larger codebase, being able to support new effects in a plain old library rather than having to have them built into the language by the language maintainer (or, worse, hacked-in by bytecode manipulation configured through annotations or something), and being able to generalise over multiple different effects or different representations of the same effect, is much more important.

(I do hold out hope that it's possible to get the best of both worlds by having dedicated syntax but only as lightweight sugar over the general-purpose syntax)
> "...on my Mac"

Unfortunately 3rd party browsers are at a disadvantage because it is harder to automatically detect and use video acceleration hardware capabilities.
Bird Flu Is Spreading in Asia, Experts (Quietly) Warn
Hyperdimensional nearest-neighbor search is a tough problem; there are index algorithms such as ball trees that work, but they don't deliver the big wins that b-trees give in 1-d space, quadtrees in 2-d space, etc.

In many "as a service" offerings computational costs are not a big deal. For this one it would be, thus making the pricing work right for everybody would be a toughie.
>What were you going to buy computer-wise in 2001? A desktop or laptop that came with Microsoft Windows whether you wanted it or not. That was your practical choice, and the courts found that though it was fine for Microsoft to own the OS market, it was not fine to leverage that into driving Netscape out of business.

And this year, I bought a laptop and found out that routine BIOS updates via UEFI capsule don't work if I've installed Linux. Microsoft still has an OS monopoly to such an extent that OEMs feel fine about failing to support any situation in which you run anything but the bundled Microsoft OS, even at the hardware/firmware level.
Yes, they don't have the stability to be used for 9-to-5 work, and they don't have the performance to be used for gaming.
Don't forget comfortable footwear. If The Walking Dead is any indicator of Doomsday, there's gonna be a lot of walking.
Call me pessimistic, but "purchase 24,000 of its XC90 SUVs between 2019 and 2021 to form a [Uber] fleet of autonomous vehicles" sounds rather unrealistic and more like an over optimistic marketing story to me. I know, a lot of good engineers are working on it and automatic vision, sensors and AI are improving constantly. Nevertheless, the Uber use case IMHO requires a solution for the most difficult level of autonomous driving - urban traffic. And without any kind of driver/ safety person/ driver awareness. For 2019 I could imagine autonomous Uber on preselected highway routes, but not in inner city during rush hour with hundreds of people chaotically crossing the street during heavy rain.
Challenge your performance intuition with C++ magic squares
Not all doomsday are equal: I see a crisis scenario where economies are in tailspin but infrastructure is mostly working - albeit getting more expensive (in ordinary currencies).

Having assets in a non-inflatable currency can be very good hedging against this kind of scenario.
NYC, have also done road trips up and down east and west coast. Never been to the middle. I think I've experienced 3 power cuts in the UK in my entire life.
Since the kotlin runtime is rather small, you still have to deal with platform differences.

I like kotlin for several reasons but this one isn't on the top of my list. If you like cross-platform development, you might want to check out haxe.
I always loved this line:

"It has not escaped our notice that the specific pairing we have postulated immediately suggests a possible copying mechanism for the genetic material."

(Your link appears broken, btw)
Thanks for the insight
It can be. But if you just need a distributed cron, you can just use the raw_exec or exec driver type and run a shell command.
Last week to submit talk ElixirconfEU – ends Sunday
Top Telegram Bots of 2017: 8 innovating and fun chatbots
The black kid who lived in the bad neighbourhood can't make it into Stuy because they already fell behind by going to their local elementary school. So now what, you want to test 4 year olds to see what school they deserve to be in?
Unless the "supply store" is shootin' back.
From Manhattan, you need to take 3 trains to get to EWR. Subway, Path (NJT), shuttle.

LGA: None

JFK: Subway,AirtRain

Compare this with HKG or LHR, it is pathetic.
Python list comprehensions (at least IME) are not that complicated or incomprehensible, at least up to two levels of nesting, with say one if clause, maybe even two. In fact, the language designers even took care (for the sake of comprehensibility :) to ensure that the two fors (in a two-level nested listcomp) have the same meaning (aka order of priority) as a two-level nested for loop, i.e. outer for wraps inner for, in both cases. It's mentioned in the spec somewhere.
Agreed. Also, the last time HN discussed this, PTX came up: https://news.ycombinator.com/item?id=15658031

> My view is CUDA has already won, and everyone else needs to get over it. Even clang supports PTX now, which is a reasonably device agnostic representation, albeit controlled mostly by Nvidia. Perhaps intel will introduce their own extensions to this ISA.

> Even if my precompiled CUDA application could run on Intel GPUs at 50% of the throughput, I'd be happy if I could later tweak and recompile it to get the full benefits from their hardware.
>"This was my experience of the US as well. Not only the state of the roads, but the poor quality of the buildings, and the incredible number of power cuts."

Power cuts? This comment can not be taken seriously. Power cuts in the US are quite exceptional and generally concern circumstance such natural disasters or a severe heat wave. An "incredible number"? Yeah right.
I'll be impressed the day this is turned on by default, or at least proposed as an option to the user after installation :).
The problem is that "Let the product speak for itself" is actually Step 2.

Step 1 is "Get people to (re)try the product".

Unless there's a magic wand waved that gets people unaware of a milestone release to (re)install and (re)launch FF57, Mozilla needs to put out some marketing just to even seed the basis for word-of-mouth of the product's merits.
How do VCs internalize startup risk?
What language is that in the examples? Yes, I've dropped out of the Javascript train.
Because it emulates gold somewhat, scarcity ( not much BTC left ) and a high demand.
I especially like when courses are not watered down. For instance, many coursera courses are simplified to be accessible to a broader audience with limited background. When I want to dig deeper, I really enjoy some of MIT opencourseware classes.
For non cattle class: comfy seat, drinks, hot stewardesses

For cattle class: carry on bin space
That's an interesting point I had not thought of before. For me, it does not make them unusable, but tastes differ. Also see my sibling comment.
I have seen structures many decades old stand just fine after hundreds of earthquakes here in Japan. I really don't think earthquake standards are an issue - more a sales point.
If you're using GNOME 3, pressing Alt+Ctrl+Shift+R screen recording will start. There should be a red icon on the message tray in the right-bottom corner of your screen. If the message tray is hidden, Super+M will activate it. Pressing the red icon will stop the recording.

Posting the videos of Chrome vs Firefox Quantum somewhere like YouTube might be an interesting thing to watch.
Ask HN: WRT Doing things that don't scale – How do I validate a SaaS idea?
So it's been repeated to death. Don't build your product until you validate your idea has strong product market fit. To do this, you should do something that doesn't scale, like set up a web page and do the work manually, like DoorDash.

OK, but what if the idea can't be validated like this because the whole value proposition is automating stuff.

To give specifics, I want to build something around setting up automated builds of Blockchains. I don't see how I can validate this idea without actually building at least some of the product first. Like, I can't manually mine blocks.

Am I over thinking this? (probably I reckon)
Only in "The Walking Dead." In real life, a raging fool with a gun can only last so long.

What you really need if society collapses is adaptability, resourcefulness, really good negotiation skills and like-minded people that help each other out.
Firefox's private browsing lets you restore closed tabs, unline Chrome, which is a small but noticable improvement for me.
Do you mean Pants is a clear winner compared to SBT, or compared to Bazel and Buck?
Show HN: A simple, scalable, flexible and economical URL Shortener for Web
Yes I know a real person that works for MTA police but no he didn't make 130k, he made 195k. Go on seethroughny.net and look it up. Try to find MTA police NOT making over 130k. Keep in mind this also includes 20 yr retirement with state tax free pension.
Apartheid seems to highlight a big difference here. Romans and Gauls could fuse into a single local culture, but Europeans were determined to keep Africans under their thumbs. It's hard to imagine the locals being "better off" for more generations of oppression.
No it shouldn't. Sometimes videos like this one are a source of unique information.
Well, that way around it makes sense. But what you wrote here could have been written in the paper, so people like me would have understood it as well.
Doomsday people are crazy to start with! Anyway, something that depends on a lot of electricity (in China!) to keep afloat, is not really doomsday-compatible!
The discovery of the structure of DNA*. DNA had been known as one of the components of cells for a long time, and the Avery, Macleod, and McCarty paper from 1944[0] showed that DNA was the substance that carried information, rather than protein.

[0] http://jem.rupress.org/content/79/2/137
Sorry to go off topic but since you mention Bosnia and it's near Christmas time I'd like to recommend reading this:

https://en.wikipedia.org/wiki/Christmas_Eve/Sarajevo_12/24

The section on "Background and Writing" tells an amazing story.

To bring it back inline, maybe a prepper needs a cello too.
Why would anyone local agree to someone having more money than them post-apocalypsis?

I am just imagining a bunch of post-apocalyptic farmers in a faraway China suddenly becoming pure slaves when someone comes with a few million BTC from Africa. Isn't happening.

The only reason BTC would survive is if it would provide the means for inter-planetary-government-independent currency. But that's not going to happen since double-spend is only alleviated with a centralised (as in - globally available) blockchain.