skysight-inc/HackerNews huggingface dataset:
Here are the links to the study (missing from the Scientific American article but in the original):

-
Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients http://science.sciencemag.org/content/early/2017/11/01/scien...

- Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors http://science.sciencemag.org/content/early/2017/11/01/scien...

Here is some earlier (cited) work in mice that very strongly showed an effect between this therapy and the mouse gut microbiome (Commensal Bifidobacterium promotes antitumor immunity and facilitates anti–PD-L1 efficacy): http://science.sciencemag.org/content/early/2015/11/04/scien.... Really interesting to see these finding preliminarily reproduced in a clinical setting.
Don't worry, I'm not completely ignorant about the work historians do.

> You can also re-discover the dates by doing your own historical research

My point was that you can put a mathematician in a closed room with only pencil and paper, and they could redevelop an entire theory if needed. A historian in the same position would be unable to do any work -- they need primary sources. I went with your "learning lists of dates" as a stand-in, since, like primary sources, you can't derive dates from scratch.

Sure, history has a "how" of research methods, but the research products must rest on the "what." Mathematics is almost entirely "how." The "what" for a mathematician is mainly knowing what's been done and what needs doing, for the purposes of directing research and giving attribution.

Also, I am pretty sure G.C. Rota was being somewhat facetious in quite a lot of the article. These are "lessons of an MIT education." Lessons aren't necessarily truth.
GParted – Gnome Partition Editor
> waste their time contributing to open source

"Waste time." I shouldn't reply to this kind of antisociality, but this is gross enough that I feel compelled to. I contribute to open source because it is the right thing to do, because I have gotten so much from it that it is only right to pay it forward. You should be doing the same, not sneering at people with a sense of community to them.
You can also move somewhere with lower taxes; say Mongolia. It's a 10% flat rate there iirc.

My guess is you like living where you do -- and it great part it's thanks to the taxes you pay.
Clonezilla
That’s true, but it costs dramatically less in places like Ireland, Singapore, or Japan to benefit from those drugs as compared to the US.
Not really - it seems that you can set your settings and get url that remembers them.

"If you haven't created a Qwant account to save your settings, you can use the following link as a homepage or drag it into your bookmarks:
https://www.qwant.com/?l=en&h=0&hc=1&a=1&s=1&b=1&i=1&r=US&sr...
The new "basic economy" fares are the ones that piss me off.

For ~16 months, I've been taking the same handful of United flights between the same locations every few weeks. When they launched "basic economy" they insisted that they would just lower the price for people who didn't care about having a carry on, assigned seats, etc.

Not surprisingly, the basic economy fare is what I was paying before and to get all the "perks" like having a carry on, assigned seating or even having the miles count towards status, it's an extra $20-30 each way.

They f*d us nicely there.
I'm nearly blind in my left eye (was born with a cataract; lens was removed at an early age before lens transplants were a thing) and I think I perhaps experience something similar.

My vision isn't really integrated between the two eyes. It's hard to explain.

I "think" with my right (good) eye.

But then I also sort of have this auxiliary eye, my left eye. I can just see vague shapes and colors through it. It's just like this... separate camera or something. I can basically pay attention to one eye or the other; they're not really "together."

Now obviously, unlike these twins, I don't have another person controlling it. But, I wonder if their experience is similar to mine. Like they have their "primary" eyes and then also this separate disconnected set of eyes they can pay attention to if needed/wanted.
ITA's Matrix[1] shows the actual price, but rumours are that Google will shut them down in the near future in favour of Google Flights following their shutdown of the QPX Express API[2]

[1] http://matrix.itasoftware.com/

[2] https://news.ycombinator.com/item?id=15594975
You make a big deal about how secondary school rankings show that Americans are idiots and use that to guess that university rankings should similarly show that American universities are poor quality.

Which is obviously why only 12 of the top 25 schools, and 4 of the top 4, are American. I'd cite the logic failures in your argument as well, but I think letting actual statistics speak for themselves works better. And FWIW, I'm citing the university rankings that's published by a non-US publisher lest you think it's merely patriotic bias.
AntiX 17, a Linux Distribution Without Systemd, Is Released
In 10 years: How Facebook is designed to be addictive
Native modules are still pretty slow. So much that we as an oss org are working with browsers to help them find ways to make them faster. Although native modules will be nice, we still believe that bundlers are still needed to ship the fastest most optimized code
That's not too surprising - Ryanair seems to have been created with all these ideas factored into their whole operation. US airlines have sort of grafted them on top after discovering how lucrative they can be.
I have programming students who come from some business or sales backgrouns. They feel guilty that they wasted all those years of experience. I tell them the same thing, the hardest thing about consulting is simply getting paid and agreeing on terms of work.
Again, disappointed. This attitude is the source of so many of the world's problems.
My experience, from shopping in Walmart quite frequently, is that they are highly disorganized and un-nimble. I guess this affords the opportunity for persistent arbitrages. For example, my local Walmart supercenter routinely runs out of certain products (not usually the same products). Sometimes it feels like GUM (An iconic USSR department store in Moscow). I gone shopping and found them missing any kind nutcracker ( a basic utensil), grapefruit juice, landscaping mulch, etc (many more examples). At the beginning of August the garden center had already moved out all its mulch for the year and filled the shelves with de-icing salt lol. The people who run the place do not seem to understand opportunity costs: they lost a sale in me and I am pretty sure nearly no-one is buying de-icing salt at the beginning of August. This is a northern USA store but where I live the weather is in the 60-70 through October: grass still grows, gardens still can be mulched. The stores are overstaffed with floor people (seemingly wandering around Lord of the Flies style) but not only 3-4 of 20 checkout lanes are open at a given time. Nearly every single canned good is dented or has a dirty lid. Their self checkout POS run on Windows 7 (lol) and update firmware automatically when they reboot which is hardly ever but for a power outage. If there are intermittent power outages in a storm a POS could reboot on the first outage and be bricked on the second one while updating firmware. There are so many opportunities for improvement with Walmart but the capital cost of a competitor entering the industry is so high. I am not sure if Amazon can be a real competitor (I think they largely serve different sets of customers).
Crank theories like this have been around forever. My dad (based on something he read in a magazine) thought it would help my eyes to go around most of my childhood without glasses on. I only used glasses for sports and when reading the chalkboard at school. It was pointless. I just went around most of my childhood not being able to see clearly beyond six or seven feet. (On the bright side, I did read a lot as a result.) Theories like this all come with personal testimonials and always have; a theory not working has never stopped someone including dramatic testimonials in their propagation of it.

And shocking though it may be, some people even put energy into promoting theories like this without any way of making a dime from it.
Oh I see.

Thank you for the example :)
Maybe they're all vaccinated? I don't know if that would cover all sorts of potential infectious disease spread through a large group of dogs.

I'm surprised they haven't started killing each other. They seem extraordinarily well behaved for a bunch of abandoned dogs.
You're very right, the internet and technology would be very different if open source didn't exist.

Basically saying, if you aren't only helping yourself and turning a profit you're doing it wrong is a little disturbing to hear.
There have to be verifiably fair ethereum gambling contracts right?
Crypto-Centives? Björk to Give Out Crypto to Purchasers of New Album
In US, Charlottesville, of course.

In Germany, well, just google for "Germany neo-Nazi march".
I recently read an excellent book about this subject exactly --

Addiction by Design: Machine Gambling in Las Vegas, by Natasha Dow Schüll.

It has research from every angle -- former addicts, the casinos, current addicts, game programmers, game manufacturers, anyone who has a hand in the industry.

It's incredibly comprehensive, and definitely worth a look, if a bit long.
Auto Complete with Redis (2010)
It even has got a broken hit counter and all... 000020083 at time of reading :)
Not sure why you're getting downvoted, I'd use the shit out of a search engine that was optimized for sites that don't use javascript for basic functionality.
I think he's referring to the ability to use boolean expressions and other more sophisticated operators. See, for reference: http://www.public.iastate.edu/~hschmidt/srch.html
What game?
I'm really liking it so far. I was able to find some obscure stuff that google failed me on with image search, using rather ridiculous queries. A few random searches also returned more relevant results on the first page. Will definitely keep using it for a while to see if this keeps up.
Prediction: no change will take place because someone else will say 'without that data, we're flying blind.'
AD Partners with New Story to Build Homes in Haiti
I really don't understand why this hasn't been a complaint at all on any other phone that utilizes an OLED display but now, all of sudden, once Apple has an OLED display it's suddenly a deal-breaker. This is craziness.
I bought a subscription to Consumer Reports and have been happy with the two purchases I made on their recommendation (headphones in the $100 range, and a new food processor).
Do you consider them compromised? It's actually just about time to renew my subscription and i've been wondering whether I should.

I've also used your strategy of reading the bad reviews on Amazon!
Yes, without a test case to sensitize a run time check, no check. Both Haskell and Python have a sane approach to types, stuff in the middle not so much.
I have one normal eye and one eye that has no lens, so I only see vague shapes and colors in that eye.

There's no shared focus, per se. (The bad eye literally can't focus at all)

I don't typically "pay attention" to the bad eye. Usually, they are "separate" and I ignore the bad eye. Sometimes I have really funny lapses in depth perception. Driving at night when the road is wet (and there are lots of weird reflections) is particularly tough. I can't see 3D movies... mostly. Sometimes that magical 3D effect kicks in for a second or two. When it happens, it's pretty cool. Then it goes away. haha.

But, my brain does seem to assemble information from both eyes somehow. I can actually play most sports pretty well. I'm pretty decent at softball and tennis.

I also avoided a serious car accident once thanks to that shitty eye. Was nearly broadsided right in the driver's door by somebody on my "blind" side, but that eye alerted me to an oncoming car (jackass running a red light) approaching at fairly high speed. She sheared my front bumper clean off (instead of plowing into my door, possibly killing me because it was a tiny little sports car with little side impact protection) because I hit the brakes at the last fraction of a second.

I would wager that the conjoined twins' experience may be something like this. (Obviously, with more eyes involved)
Your expectations aren’t reality. If you have a solid middle class job like a policeman, corporate manager, or soldier, you will be fine in Mississippi or South Carolina. The major difference is that state protections will be weaker than in places like California or New York, and you may need to travel to a regional center to get specialized care in some situations.

If you are poor, however, forget about it. Those states are openly hostile to you and generally opt to find the minimum number or services allowed by law. They are so bad that many people establish false residency in states with better systems.

The way these programs are funded, it makes little difference to state balance sheets — it’s all about appealing to particular political bases, and keeping certain taxes (typically property taxes) low to keep the old money people happy.
The Internet has become a carrier signal for advertising.
There is this one that sort of fits the bill: http://www.sacred-texts.com/

But that might not be the one you mean... I recall one with a black background... hmm.

/edit/ I also found this one: http://www.crystalinks.com/ ...I (probably badly) archived a copy of it around 2000/2001, back then many pages had dark graphical backgrounds. It seems that has changed.

There was also the Temple of the Screaming Electron, which has since disappeared. https://en.wikipedia.org/wiki/TOTSE
You do realize that you’ve just invented capitalism, right?
Microsoft built a secret network emulator it says can prevent most cloud outages
The article is very hand-wavy about the core rent seeking argument. There is much discussion about factors such as productivity improvements concentration of market power and mergers and acquisitions.

From TFA: "says Blankenburg, “the data show very clearly that the means used to obtain these profits cannot be reduced to the use of productive technologies.” Other mechanisms, such as lobbying or mergers and acquisitions, the authors find, have played a significant role in enhancing the market power of dominant companies. “You can show quite clearly how surplus profits increase with mergers and acquisitions, or how changes in regulation that favor control over intellectual property rights for large corporations have a pretty-instant impact on the profit performance of those companies,"

That's the sum total of the rent seeking argument. There is nothing in there demonstrating use of IP to extract rent (which, arguably isn't even rent seeking behaviour, but for the sake of argument may be granted here). My intuition is that profit extraction due to IP for the very large companies is most obvious in pharmaceuticals, but that's just my guess?

There are a few interesting points in this article, but it's weakly written.
Robert Zubrin, founder of the Mars Society and author of "The Case for Mars" and "Mars Direct", has a Ph.D. in Nuclear Engineering. In his review of a different article on the same topic, he writes [1]:

"On a Mars mission, astronauts would receive a dose of 1 rad per month during the 6 month outbound and return transfers, and about 0.5 rad per month during 18 months on Mars, for a total of 21 Rads. (1 Gray = 100 rads)".

In the paper, the animals were irradiated "at dose rates between 0.05 and 0.25 Gy/min".

Zubrin writes that the huge difference in dose rates (0.01 Gy per 60 * 24 * 30 = 43200 minutes vs. 0.05 Gy per minute) makes such studies completely useless because at the lower dose rate the body can self repair and at the higher dose rate it can't.

Quoting him again:

"For example, if an individual were to drink one shot of vodka per second for 100 seconds, he would die. But if the same person drank one shot of vodka a month for 100 months, he would experience no ill effects at all. This is about the same ratio of dose rates as... ".

1 - http://www.marssociety.org/r-zubrin-radiation-hucksters-stri...
Ask HN: Good resources for learning UX/UI Design?
I am studying UX/UI and searching for UI/UX design resources is riddled with graphics design, javascript, name-your-favorite-web-app-frameworks, etc.

When I started learning about Data Science, one of the best resources I've found is Hadley Wickham's books on ggplot2 and other excellent books such as Semiology of Graphics, The Grammar of Graphics, etc.

What are some of the classics in UI/UX design that are truly timeless and talk about the abstract UI/UX concepts and not some concrete framework?
Jesus, that website must have taken years to make. The reviews are so in-depth, fantastic. I've been looking for someone that reviews USB chargers, as they go into mains voltage and are dangerous if not shielded properly. Amazing resource, thanks for linking it!
This drives me nuts - not only is it more money, but it seems that most of the people with Economy-- tickets don't realize it and get into fights with the gate agents. It's amazing how effective it is for turning all of the people in the airport against each other.
> So the same action is called by different names depending on who does it?

Exactly. "Terrorism" is just a label to describe the parties involved, not a value judgement. A death is a death whether it's from guerilla warfare, a mass shooting, terrorism, an accident, or a full scale war.
Μικρό αγωνιστικό πρόγραμμα με προοπτικές
It's OK, reasonably fast, and I do like the interface, but search results as a list is so 1990s. Give me the result as a DAG. Give me sort options. Let me pin a result and then iterate in relation to it.

Show me something different, not the same thing as everyone else with a promise about my privacy and some different graphical sugar. To beat the established competitors you don't need to be incrementally better, you need to be qualitatively different.

I do prefer it DDG, at least for desktop use, because it's actually using the whole of my screen for a change. But wow me with something. I haven't had that in a while.
The words are pretty much par for the course in academic writing.

That font, though, is inexcusable.
I know you're being coy picking the example from your list where the market leader wasn't simply forced out by an even bigger market leader.

But in fact we have seen a lot of consolidation in the photographic industry. Back in the days of film everyone had to choose from a select few manufactures of chemical film. but people who created photography had a wide variety of equipment manufacturers to choose from, and those who did it professionally had a wide variety of sales channels into which to sell what they produced. Good photography was valuable and many thousands of people could support themselves as freelance photographers.

Now we still have a decent set of SLR vendors. There's Nikon, Canon, Sony. Um, probably some Chinese manufacturers. The point and shoot market has been eclipsed by the camera phone, for which there are now exactly two platform providers.

But the collapse in price of photographs also produced a collapse in value of photography. All those freelancers found their sales channels dry up. There wasn't Look or Life or Nat Geo or hundreds of other publishers who needed photographs and were willing to pay top dollar for excellent work. Instead photographers found themselves trying to sell the rights for pennies on a few photo agency platforms, or more likely surviving entirely on event work.

The choke point at film manufacturing went away for sure, but we have a new choke point at the publishing and delivery end, and this choke point exerts vastly more control over the entire industry than the film duopoly ever did.
Well, if "terrorism" is just a label, then it shouldn't matter if war is labeled terrorism on a larger scale.
Was feeling the same way. No need to end a good experiment and we don't know the ceiling yet.
Think of that one Little Caesar's pizza I can get;)
It may be this stuff is true for current slot machines, but it isn't immediately obvious if you try one. In fact, current slot machines are an incoherent mess.

When I played recently, I couldn't tell whether I had a near-miss or even a win until credits counted upward. I couldn't feel any excitement because I didn't know what was going on. It would have taken me several hundred dollars worth of play to even understand what was happening. Maybe this is part of the plan, or maybe their product gets used no matter how bad it is - as long as those rewards pay out randomly.
I swear the last five years or more of searching for products lead to the first two pages being fake reviews/ads. Google must make money from this otherwise they would fix it.
Fieldplay: visualize math
Why isn't the conclusion that the political systems are too powerful then? Regulatory capture and IP issues are the fault of a political system that can wield too much power.

The limited government people would seem to have a strong case that power should be removed from the political system since it is so easily corrupted.

I don't quite understand how the answer to a political system easily manipulated is to make it even more powerful.
I sometimes fantasize about having one of these companies as a client and billing them with fees mirroring the ones they charge i.e. add a fee for “mandated federal and state taxes” (my income taxes), maybe an “internet surcharge” and of course a “fuel surcharge”. My biggest expense next year will be insurance so I’ll definately add an “insurance fee” that in there as well. I’m getting giddy just thinking about it...
Yeah my bet was that they decided on the language first then built the tooling afterwards. Rust person was probably saying the same thing as it was happening...

Rust can be really daunting to look at, and if you compare the rust book to the go language tour, the easiest one to learn is pretty clear -- I get the feeling they won't even regret the choice because the things rust protects you from go sidesteps by giving you slow-but-safe-and-restrictive channels. Go's data race detector also is probably gonna be good-enough for a long time.
If only Lincoln has PowerPoint

https://norvig.com/Gettysburg/sld001.htm
Thank you for the expansive answer - I can really see where you're from now and I agree with your issues in Python. It's interesting to me that you go to Julia as a solution (I mean that honestly, I want to play with it when an exploration phase comes up).