skysight-inc/HackerNews huggingface dataset:
Calico probably thinks of itself as the Manhattan Project. Organizationally, Calico seems to be built in the exact opposite way from the Manhattan Project.

Imagine you were building the first fission bomb, but doing it the Calico way (which is the way most science is done these days). You'd say: we need enormous progress in a wide variety of very distinct fields: nuclear physics, isotope chemistry, metallurgy, high-speed photography...

So you'd ask PIs in all these fields to send you grant proposals related to the problem of building an atom bomb. They would take their existing grant proposal template, rewrite it to talk about atom bombs, and send it in. You would send them money. They would deliver progress reports.

What would happen? Probably, you'd build an atom bomb. The first test would be in 1986, after 45 years and 500 billion dollars. It would cause major damage to three creosote plants and severely startle a jackrabbit.

Next, imagine Calico's funders said: we will take this same amount of money, and pour it into a single problem -- rejuvenating a dog. Much like Manhattan's single product deliverable.

Moreover, we will not hire existing players to repaper their existing lines of research. We will hire the best new PhDs and tell them to do whatever want to do, so long as it represents one piece of a reasonable strategy for, or step toward, an realistic engineering procedure for rejuvenating dogs. (Or at least mice, if long-lived animals are too hard a first step.)

In this kind of organization -- ie, a hierarchical company-shaped structure with a company-shaped goal, delivering a product -- the standards of relevance and collaboration will be much, much higher. Los Alamos hired the best people in the world, but no one took their existing research and tried to shoehorn it into the Manhattan Project.

No wonder our grandparents could get big things done, and we can't. We actually put a lot of money into science and technology, and the personnel are just as talented as ever. Every PI is an Oppenheimer. But there is no General Groves.
So one orange, a large apple and a banana per day will hurt my liver (totaling 63 grams of sugar[1])?

Where is the scientific evidence supporting this?

[1] http://www.sugarstacks.com/fruits.htm
I've seen surprisingly little on running "fat" services in a serverless (like AWS Lambda) environment. We're doing this at work pretty successfully so far: Django projects with many endpoints within a single Lambda function. There are limitations to work with (50MB compressed code) but they're quite manageable for some time, and so far a nicer problem to deal with than all the things we give up by abandoning serverless. So try adjusting your example to something like a dozen lambdas for an engineering organization of 50 devs, with each lambda service boundary roughly matching the team and product structure.

Serverless enables the extreme (many tiny services with minimal upfront cost) but doesn't require it.
https://i.pinimg.com/736x/45/2c/2d/452c2d0569d1015f4a0b2ea27...

Edit: Now that I think about it, maybe the Swedish 90 (_nittio_) should be seen as "9×10" (_nio_×_tio_), since that's at least the etymology. I don't know what to make of the German _-zig_ in _neunzig_. Regarding Japanese, I dont' speak any. Finally, if you allow yourself to dig deep enough into the origins of the French and Danish 20 (_vingt_ and _tyve_, respectively), it appears that they too could be split further as "2×10".
The other interesting thing about French is that Swiss French and Belgian French have both fixed this - ninety is “nonante” instead of “four twenty ten”. Belgians use “quatrevingt” instead of the Swiss French “huitante”, though.

The oddest thing of all is apparently the simplified form is an old French usage that got replaced by the Gettysburg-Address-style “four score” more recently. Why they would change in that direction is a mystery to me.
I thought about as soon as I heard of the technologies. There is the one part, validating results of sports events to initiate payouts, the setting up of new events, that would seem to make it more difficult without some sort of scraping, or intervening party.
A lovely place in Western Europe.
I'm French and I hope we do not align with the American cultural doctrine of self-reinforcement, which has, I dare say, slowly drifted towards a worrying train of thought were everything is equal, any opinion has value, any choice you make is to celebrated.

By all means, I don't see shaming as the sign of a healthy society and I hope for people never to have to suffer humiliation or belittling, but there should be, in my opinion, a certain level of acknowledgment that being overweight has dire consequences for not only one's health on the middle to long term, but also terrible side-effects in terms of public health and the economy at large.

As we're spending dozens of billions caring for diabetes, cholesterol, hypertension, heart attacks and the myriad of other diseases that correlate heavily with the lack of exercise and an unhealthy diet, we're neglecting research, schools and the social fabric that used to make France a great country to live in.

The ultimate irony is that we used to have a formula that worked just fine to gift us with one of the highest life expectancies in western societies a few decades ago, before we decided that Burger King, Coca Cola, Subway, McDonald's and KFC really were what we had been missing for so long.
Russia is kinda actually like that. Tech usage is relatively good in Russia. Internet is cheap and fast, mobile coverage is good and mobile internet is relatively cheap, internet banking & mobile banking is better than most of Europe and USA. There's also such thing as "Gosuslugi" which is country-wide services internet portal and is actually pretty convenient innovation.
Not really, minimal bridge only has to be written once and is reusable across any language that compiles to Web Assembly.
<rant>Yes, but I get annoyed at some fat white western guy claiming that all those poor brown people a long way away are the problem. We (my family in the UK) managed to cut tonnes per year off our footprint while raising two kids in the UK; not that hard. Some would much rather blame others rather than even make any effort.</rant>
Yes, but that's actually a great thing. It allows Google to discern controversy. If people disagree about a fact, that's fine, Google can choose how to present facts that have that property. For the ones people do agree about, they can present them as truth.
The most common elements on the moon are quite common on the earth too; I don't think the value in mining them will ever come from bringing the mined materials back to earth. The value is going to come from having and maintaining an established base on the moon. The moon is a high point in the earth's gravity well that's full of raw materials that can be used to build things that can go further out. Mining on the moon is going to be about building and supplying interplanetary (and maybe interstellar) spaceships, not selling jewelry back on earth.

[0] https://en.wikipedia.org/wiki/Geology_of_the_Moon#Elemental_...
Are you talking about Chromium or Chromium OS? They are very different things. Both of them have working OSS forks, or just work out of the box.

Chromium (Browser) - Just chromium. Works without changes (except for Widewine EME). WebRTC is an open standard, and Google primarily uses open codecs like VP9 and Opus. Can you point to something you think says about restrictions?

Chromium OS - Neverware sells a fork ('support' technically) to schools. You can download it for free.

Android - Dial a phone number? Are you talking about the modem firmware? That's the phone manufacturer's fault, not AOSP's.

There are obviously differences between closed source versions and what you get by immediately compiling. This is true when you have a real permissive license (non-copyleft) like Apache or BSD. You can't expect a company to release little thing, especially when that involves divulging info about other products they don't want to.
It might be worthwhile to use a library like Flask which has less batteries included. This will force you to figure out which pieces of the puzzle you are missing and will (hopefully) allow you to learn a lot through exploration.

Once you understand what everything is doing, going back to Django, you should understand what all of the components are doing.

Django & Flask are not exactly one-to-one with the way they handle a lot of things, but I think it would still be a useful exercise.
The IP is gone apparently.

Seems that Chris Hinsley (inventor of TAOS) is working on a modern day version of TAOS. [0]

[0] https://github.com/vygr/ChrysaLisp
In English, I've noted people do not like thousands.
e.g:

- 20,000 is 20 k or 20 grand.

- 1900 is 19 hundreds not 1 thousand 9 hundred.

In Japanese numbers are also different:

- there's a word for 10,000 (man), therefore 20,000 is not "20 x 1,000" (ni jyu sen) but rather "2 x 10,000" (ni man).

- there's a word for 10^8 (oku), making 1 billion = jyu oku (10 * 10^8).
Yeah, he's kind of focusing on only his field, but that's OK. AI and genetic engineering are clearly just getting started, but if it's not in his field then it might make sense for him to not care.
Just trips, specific days, or little photos that remind me of someone or somewhere. Childhood memories are great too - just write them down with as much detail as possible.

It’s not entirely different than looking at old photos, but the SRS system keeps the memory fresh.
The linked page explains that fact checks aren't guaranteed to be displayed, but use an algorithm similar to page rank to choose which if any checks should be shown.

Fact checking doesn't automatically mean people will believe the fact checker over the top link anyways. Exposing people to disagreement to the issue from the start may be important because once people form a belief, they're much more likely to hold that believe despite contradictory evidence.
Pretty much. Google was sad when it realized that 10^x layers of "Deep Learning" couldn't detect propaganda, and it will be sad when trying to get people to do it for free doesn't work, either.
Critical software is rarely written in anything except languages with explicit memory control, usually C++, and usually with very strict guides. There is a famous programming guide for flight control systems in particular that discusses how to properly use C++ for maximum safety during flight. It includes things like never allocating memory after take-off.

You wouldn't want Clojure, Java or any languauge with GC running in a pacemaker either. Those are all also very important distinctions.
I don't know the rate of atmospheric loss, but it might be possible to introduce air at a high enough rate to outstrip the losses, making for a sustainable atmosphere. It would presumably depend on the availability of ice and other volatiles.
> Without saying how much is too much

Body weight, metabolism and exercise have to be big variables.

The scary part is how much sugar sneaks into your daily diet without noticing - I kept count of the sugar grams per day for a workday and I had about 98 gms of sugar & that's where it got labelled (unlike a tomato sauce pasta).

Anyway, all it taught me is that even if exercised like a madman, I won't lose the "moved to US" weight gain without minor diet changes - but what surprised me was that my diet was a good one in the meals, it is just the middle-of-meals grabbing of things that pushed that number up (like a yogurt).

> How many dates would be enough to damage my liver?

I was told that there's two ways to drink twelve glasses of alcohol a month - one's to hit six for two weekends and the other is to drink a glass on Fri, Sat and Sun.

And then said "it's like three pats on the back a week or two punches a month".

Bodies heal and repair damage - and at a varying rate as you age.
> Isn't it fundamentally impossible

No. Can an extrovert become more introverted? Of course.

It may not feel "right" but it's fundamentally possible. The brain (more precisely, the stories we tell ourselves) are malleable. Age, location, friends, lovers, jobs, all weigh on which type of -vert you are. That's been my experience anyway.

Although I do think it's a slope with introverted at the bottom. I.e. it may be easier for an extrovert to become introverted than the opposite.
Is it possible to buy processed foods that have no fructose.
Certainly, fructose is sweeter and that's why it's used so much. But would be great to avoid it altogether. I know you can bake with dextrose.

I wish I'd taken chemistry. I see a lot of conflicting statements about isomers of glucose.
>Too much of everything is always bad.

That's folk-wisdom, which is sort of a good heuristic but is not useful when we can actually test and demonstrate. Some things are bad even in small quantities, say poison. Somethings we can't get enough of, say fresh air.

I've mostly cut out fructose (and most other forms of sugar) altogether from my diet and it's probably the single-most impactful change that I've made in my lifestyle on my well being.
"God exists" is a bad example of progressive/conservative.

This is not the forum for this kind of debate.
Sounds a lot like Spain, rules and paperwork. Taxes are lower but so crappy that even with an accountant you often pay the weirdest things and cannot declare many of the legitimate expenses you might have so in the end I pay as much as I did in NL.

The Estonia e-residency is very good for ‘nomads’ ; if you travel a lot (say you do not reside in one country 6 months + 1 days and (but this is debatable somehow) are not in a country more than 60 days continues, you can have a company in Estonia and declare tax for that company there. Which is to say, no tax until you take money out. If you don’t travel like that it is far more complex.
Not the parent, but I think of it as analogous to running an emulator/VM. That is, if your reactions to input are those of an extrovert, does the interior process of how those responses are generated really matter?
I hear as bananas ripen, the sucrose breaks down and more fructose is available. That's why they get sweeter. So healthier not to wait too long.
Syntax similarity probably reduces the "fear of new" (different) that prevents some people from making the transition. But the biggest factor is that the creator of Elixir, José Valim, is a well respected Rails contributor.

But indeed, Elixir is so different from Ruby that one doesn't just casually move to it from Ruby without learning to think functionally.

To your question about Rails, I'm not sure I can say whether it's in decline or not. But I do know that many hiring managers are not technical enough to know what's important, so they try to replace exiting employees with people who have the same skills. And probably there are one or more Rails apps that still need dev/maintenance. As far as money goes, Rails is still a very lucrative career focus, at least in the US.
Yeah, Gusto is a big win IMO. Payroll stuff sucks, especially for early stage businesses. I've used all the services over the past 15 years, my current company is using Gusto, still sucks, but sucks the least, best price, best service. And 1000s of small businesses trust Gusto to process millions of dollars of their most sacred money each month. Underrated.
This is a silly argument. You can't seriously be suggesting that the bacteria are choosing to modify their DNA in anticipation of future benefits. For sure, nothing is ever 100% absolutely known, but some things are so unlikely that we can safely assume they are not true, rather than putting a wordy disclaimer on every single "fact" that we state.

Getting back to the original point, people, including me, will say things like "this shopping cart wants to pull to the right" knowing full well that the shopping card has no desires at all. It is a useful metaphor that confuses nobody.
> The only way the Estonian system is better is that the law dictates this number not to be treated as sensitive or identifying information

That's precisely the issue with SSN.
The reason why our satiety mechanisms don't work is because carbs upregulate insulin, which supresses leptin [1]. Leptin and ghrelin are the two main hunger hormones; leptin tells our brain we're full. The signal doesn't work too well in the presence of high insulin, and gets worse with insulin resistance, causing people to have a "second stomach" for sweet foods.

https://olumialife.com/knowledge/how-does-insulin-affect-lep...
> Are you talking about servlet filters? Because any web framework is going to have a few of these. Spring MVC adds a handful and all of them can be removed, replaced or added to. Spring Security adds a bunch and all of them can be removed, replaced or added to. But the defaults are chosen because of feedback, not just for the heck of it.

Even ignoring filters, it seems to me that Spring brings a lot of overhead. Adding an annotation to a method sometimes means that would appear to be a direct call between two of your beans is in fact separated by 10 method calls on a stack trace. In many cases this is not an issue (expecially in "enterprise" applications), but it is clear to me that performance is not really one of the main concerns of spring developers.
How People Inside Facebook Are Reacting to the Company's Election Scandal
A conduit is only valuable if they have a monopoly. Otherwise they just become a dumb pipe, with the value all being conducted back to the service.
Everyone: "We've got a problem with fake news and journalistic integrity on the internet."

Google engineers: "Oh, I can make an API for that!"
Yes, oxygen and hydrogen mixed together will eventually react to form water. To react, atoms or molecules simply need to collide hard enough to overcome their initial repulsion and form bonds. In space it is a slow process, because the pressure and temperature are both low - this means the atoms rarely hit each other, and when they hit, they don't hit very hard.
This is a great train of thought.

Are there any Manhattan Project Level undertakings out there? If not, is there a Patreon for one? ;)
That's why I said "unbound" fructose.

Sucrose is glucose and fructose with a chemical bond between. HFCS is a slurry; there's no chemical bond connecting the two.

"Broken down in the small intestine very rapidly into 50/50..." ignores the fact that it takes a while to make it down as far as the small intestine.

I can't speak more to the differences personally because I'm not the one with the PhD and I'm not going to interrupt my wife from grading papers just to correct some rando on the Internet. :)
Psychological uncertainty is tiring. When I'm dealing with a problem and I have no idea how to solve it, it causes anxiety and I feel drained. When I learn more about the domain and have a framework for processing the problem, then I feel far more assured and energetic in handling it.

I think dealing with diverse people is the same. When I have a better understanding and "frameworks" to interpret what's going on, I feel a great more certain and confident, and this makes difficult interactions easy. This means I can do more "extroverted" activities and genuinely enjoy them - with less uncertainty/anxiety attached. I still go home to fully recharge - I'm not sure if it's possible to change that, but I can drastically change how long that battery lasts.
Or say ... Russian propaganda machines. And now we've come full circle.
so we have another proof that stargates exist and ancient aliens were here? ;)
>Scientific evidence on fructose and the liver is relatively new

People have been force feeding animals to fatten them up (gavage) for about 5,000 years, but specifically feeding them sugars/grains for the purpose of fattening their liver.

Ever hear of the French delicacy Foie Gras(1)? It literally means fat liver, and after 5,000 years of perfecting fattening liver what do we force feed the animals? Corn! The same fructose we highly concentrate and load into foods and drinks and feed to kids...which goes hand in hand, per the article, with why kids weren’t diagnosed with fatty liver disease pre 1980’s and now 13% of US children have it.

(1) https://en.m.wikipedia.org/wiki/Foie_gras
I'm unfamiliar with the state of the art, but could this make it possible to target iOS with a bundled JVM?
-1 => "Not even wrong/conspiracy theory"

Honestly, this isn't the sort of thing that needs to be fact-checked. It just needs to be tagged as being baseless. It's a little different than the types of things this solution is aimed at.
> citing a book whose French author described with horror seeing Americans eating alone, or at any time of day.

> “France is a very rules-based society,” Ms. Saguy said. “There are rules about eating in France, about mealtimes, and you need to follow the rules.”

I would call that BS. French people eat whenever they want and nobody cares really. That being said, my personal experience is that French (and Europeans in general) are still much more conscious of what they eat than Americans, which is probably why they are thinner. I was surprised while living in the US to see even very educated people feed their kids with junk food and sodas.

However, this is gradually changing. More and more people eat junk food (e.g. Mac Donald's is extremely popular in France) thanks to food corporations propaganda and lobbying. Not surprisingly, obesity rates are increasing. Small relief, obese people won't be discriminated against when we're all fat.
So is gitkraken.

But I assume these apps have spent a considerable amount of time in optimizing electron, which not everyone can do.
Better off just closing your laptop then, as most sites rely heavily on JavaScript.
Browser as Botnet (talk)
I'm not sure synchronous=off qualifies as incredibly dangerous. You can corrupt the database with synchronous=off, but only if you loss power or take an OS reboot in the middle of a transaction. Even with synchronous=off, transactions are still ACID and the database is guaranteed to be intact following an application crash. It takes an OS crash or power failure to cause problems.
Pretty sure Schmidt has read all of his books.
The Virus Hunters: The Search for the Next Deadly Pathogen
The Starship delivery robot is real, but it's not really operational. One can be seen in downtown Redwood City, wandering around with a keeper following it. It's been doing that for six months. They have a few in Estonia, a few in San Francisco, and a few in London. All demos.

Starship reminds me of Better Place, the car battery swap company out of Israel. Too much PR, too many demos spread around the world, not enough profitable deployment. It looks like they're trying to make enough noise to be acquired by Amazon and exit, rather than actually providing a service that gets used.
I can appreciate your desire to share the good news about Clojure adoption, but I don't think the language is in need of defense. It's used a lot all over the place, and you shouldn't feel the need to convince others of that. Because even if it weren't used hardly anywhere, it would still be a great tool for those of us who do use it. That it is in fact in use in a lot of places, regardless of its specific role, is just a nice added bonus.

If someone doesn't want to use it for this reason or that, it's their loss not ours. Those who need to find Clojure eventually will, because there is nothing else like it.
There probably is a genetic component to obesity, but that is only a thin sliver of the problem. People 200 years ago had indistinguishable genetics from today yet obesity was rare enough that it was a curiosity. Something has changed in the last 200 years and the list of suspects is basically down to diet and/or exercise.

I feel sympathy for nicotine addicts, just as I do for the obese. It's hard to pin down exactly how, but society (meaning some combination of their parents, peers, education, and government) has failed them. Focus on genetic components to obesity isn't technically wrong, but it doesn't help anybody get better.