skysight-inc/HackerNews huggingface dataset:
Thanks, here is an example of the type of questions I would expect a doctor to ask (which is impossible if no study is published).

Looking at your paper I can't really tell what they did to determine CR. Did they only do PET-CT? The paper they cite[1] mentions some biopsies (for some cases), etc but they only show any results for that assay.

Assuming it was only PET-CT for now, they say[1]:

"Typically FDG-avid lymphoma: in patients with no pretreatment PET scan or when the PET scan was positive before therapy, a post-treatment residual mass of any size is permitted as long as it is PET negative."

So positive/negative is apparently based completely on relative metabolic activity. Just looking at figure 1B in your paper, it appears that baseline vs 30 days is done perhaps using different exposures. Or for some reason the intestines were much more active at 30 days (patients ate more recently?).

1) How do they ensure there isn't some response to the drug/environment that has increased general metabolic activity, thus decreasing the relative signal from the tumor?

2) Were the people processing and examining these scans blinded to the fact they were part of a drug trial? There seems to be ample room to play with exposures, etc here.

[1] http://ascopubs.org/doi/10.1200/JCO.2006.09.2403
> Your original argument implies that if killing someone is easier with a sharp blade, then I should be more willing to attack someone as it becomes cheaper for me to satisfy this unexplained demand for murder.

Your problem appears to be in elementary school reading class, not in statistics. I didn't say a person with a gun or a better knife will be more likely to attack somebody. I said they would be more likely to kill somebody. Once you understand that, you can move on to the statistical reasoning to understand why that is so.
Are there any sort of dead simple Wayland compositors, like MWM or OpenBox, for people who doesn't want the full KDE or Gnome desktop, but still prefer a tiling windows manager.
RDBMS makes sense for most applications. Most applications store data that can be fit to the relational model. Most applications aren't big data or data mining OLAP.

Most RDBMSs can do key-value stores very well now. Most applications also care more about consistency over availability, which is what RDBMSs do (CAP theorem). Many NoSQL data stores choose availability and partitioning and sacrifice consistency (i.e., "eventual consistency"). There's a lot of applications that you can't sacrifice consistency for. Electronic health records, financial records, student records, employee records, etc. You care that the data are accurate and up to date, and you want the system to error if it can't provide that. Wrong answers and "close enough" answers aren't good enough.

Now, if you're running Reddit or Wikipedia or Facebook or HN... do you really care if a user doesn't get the absolute latest version of a document or comment? No, not really. If the content is hours old it's a problem, but it's not a big deal if it's a few minutes out of date. You care more that your users get a version of the document more than you care that they get the latest version of the document.
Don't let the gratuitous negativity get to you! I may only see a very small slice of what the BBC does, what with being one of those continental imperialist and all. But what does find its way to me has always seemed to be excellent.

(Not a job application. Unless you know something about the EU/British future that I don't.)
> the instructions of the red light have to be followed regardless

No they don't. If there's no enforcement, and no moral reason to follow the law, you've reduced yourself to a robot if you follow it.

As far as red lights are concerned though, you'd better be damn sure cars or bikes or pedestrians aren't going to leap out from around a corner before you run them. Especially if the intersection is empty at 3am and visibility is poor. In fact in that situation it's better to play it safe.
Yes, I enabled Python and Go (and other things I use), but only the standard library is covered. The language reference is not available. According to the README on GitHub, it looks like it's a design choice to focus on APIs...
I thought that the primary constraint here was hardware, and specifically resolution?

Is it actually possible with current hardware to have a workable development environment... err... ... world?
I wonder if people see the word Google and just freak out. If you read closely you'll see it's a bid. They are preparing a plan but City officials still would need to approve the plan. Y'all acting like Google bought the land, which isn't true.
> Profitable in their current markets. Once they expand internationally they will need to subsidize heavily.

Why would they need to subsidize outside of the US?
+1 to this. KVM and virt-manager Just Work for me on Debian 9. I don't know what I was doing wrong with previous releases but I just installed it, added my user to the correct group, and there I go.
I use KM Player, which allows up to 3 subtitles at a time, although the 3rd subtitle is placed right in the middle of the video (the first is on the bottom and the second is on the top, which works very well).
>It seems to me that there may also be a market for people happy to pay $70 for the same thing, with the ability to specify which browser, and have the list of available browsers include the ones that are kind of inconvenient to support (older IE).

Mark me down on this list. In particular, I'd like an API that lets me have a more detailed look into the web page - for example, list all images used by the web page (this is a lot harder than it sounds once you consider images can be loaded by CSS, IMG HTML tag, can be delayed loading, etc).

In short, I'd love an API where I can see the same details of a webpage as Chrome's debugger shows. I looked into Chrome headless, but there was some issue with hooking into the debugger (admittedly I know only the basics about Chrome headless).
When you get the design right, there's no need to change it. :)

Jokes aside, I refuse to let Arc die. There were genuinely good ideas embedded in it, amidst the rough edges. People just never forced themselves to use it. It's like if Vim was invented but had no documentation, so no one ever realized it's powerful if you embrace it.

But yeah, I imagine my version will have a different name and a shiny website. Being a decade out of date does matter, especially for hiring purposes.
You may be better served by Lektor: https://www.getlektor.com/
It's been an Oracle product for 8 years, I wonder why you chose this particular release to think about searching for alternatives. Maybe you just wanted to pay tribute to John Dunsworth.
In short, they're going to build a neighbourhood from the bottom up.
I have no idea what that site is, or who those people are, but I agree with them. I also have to say that I’m in for anything Braga cares to bring; he’s a real talent, a true Trek fan, and a genuinely decent guy. Some of the best TNG eps were written by him.
For intellisense/documentation it means having method names, arguments, types, and short summaries pop up as you’re typing. E.g “print” might complete or printf and give you all you need to know to use it on the spot. While vim has autocomplete, I’ve never seen this documentation feature (even typed argument listings) and it’s extremely valuable to me.

Tags require a lot of manual work, so I consider them in the “worse” category of vim support for ide features.

Also, you shouldn’t mention gdb because the Ux is awful next to IDE integrations. Really. There’s no comparison here.

For unit tests ides can run individual unit tests with a single click.

Again, vim may support some of these features, but it’s UX is awful next to IdE Ux.

Also, I’ve been able to use VSCode over sftp, although it’s true vim can be pretty nice here. Personally don’t want to cart around a whole folder of plugins on top of vimrc, sounds like a pain.
Hyperbole, the first resort of trolls.
I didn't mean that the city itself was founded recently, more like compared to other east coast cities such as New York, Boston, or Montréal, a lot of parts of the city was built recently.
Should we be reminded that bugs such as Apple's GoTo Fail can exist? Or like Heartbleed, which actually was in open source software?

If they were to put a backdoor in it, whoever would find it would probably just take it for some error they made in coding.
actually, i beg to differ. my wife has a 90% remote job and has a desk @ wework in berkeley. i've met a ton of her weworkmates and while a large percentage are entrepreneurs, many are remote workers or self-employed.

even the small amount of infrastructure that wework provides to it's members is incredibly useful: wifi that always works, coffee, lounge area, meeting/phone rooms and generally a quiet place to focus and get work done.
Powerful is a strange choice of word. Did you meant to say more expressive?

I feel like if anything, Rust sounds more powerful to me, greater performance, control over memory, low level unsafe access, etc.
One idea is if the call to the random number generator was designed to return either random data OR an error code indicating failure. Multiple failures of the same type would therefore produce the same numbers, barring any sort of "mixing" with other random or non-random data.

This is wild conjecture of course
Try not to remove context like that. My reply looks quite strange now. :)
Just a pond and wide angle:

https://www.google.ca/maps/@45.4325043,-75.6175154,97a,35y,1...
This is cool, and props for scratching your own itch, but this does seem like an incremental/niche improvement over Hugo. I'm curious if you talked to the Hugo community about supporting those features? I don't mean to imply that you should have done so--"I wanted to build my own" is a totally valid reason not to bother.
They even got through Jepsen just fine after wiredtiger.

With non-default settings[0].

The Jepsen tests passed with the "linearizable" read concern. The default read concern is "local", which "Provides no guarantee that the data has been written to a majority of the replica set members (i.e. may be rolled back)."[1] This is like having "READ UNCOMMITTED" be the default read level in a traditional database system.

The Jepsen tests passed with the "majority" write concern. The default write concern is "1", which means only the "primary" in a replica set needs to acknowledge the write[2]. This does not guarantee safety in the face of network partitions.

It's still not safe out of the box.

[0] - https://jepsen.io/analyses/mongodb-3-4-0-rc3

"With the v1 protocol, majority writes, and linearizable reads, MongoDB 3.4.1 (and the current development release, 3.5.1) pass all MongoDB Jepsen tests:"

[1] - https://docs.mongodb.com/manual/reference/read-concern/

[2] - https://docs.mongodb.com/manual/reference/write-concern/
Solar panels, electric bicycles, and not completely-effing-crazy urban design is actually a pretty easy answer.

But everyone wants to live on an island of asphalt with a sterile, depression patch of grass in front, at least three miles away from the nearest place to buy a cup of coffee (a disposable cup, natch).

Actually, not everyone does, but those who do, made it illegal to build anything else. At least in the US.
As a species, we are the apex predator. As an individual in any particular encounter I may or may not end up being the apex predator. I usually have bear spray with me, but I only have a rifle when I'm hunting. I'm not sure I could kill a bear before it took me down, so I'm actually happier to carry bear spray than a rifle for protection from bears. Of course, if we're doing rescue work where bears may have already been acting predatory towards humans bear spray is not an option and we carry several bear-stopping rifles.

I've run into 30-40 bears in my lifetime, and all but one of them ran away as soon as they saw me. One lingered a bit, and that was a scary but life-affirming encounter.
> I would love to get away from Android, but this is helping as much as Ubuntu on Windows is helping to get away from Windows.

I'm not sure how much this helps, I'm just replying to the idea that we "Android already IS linux". That is technically true, but not practically true. I also don't want Debian to run on top of the android kernel, but I want to use Debian's kernel. The android one is pretty neutered and crappy.

And yes, it is half-assed linux precisely because it's intentionally not compatible with desktop-like environments. Android has different goals than I want out of a phone, and that's perfectly fine, but that doesn't mean I have to be happy with Android as my only option (excluding IOS as that is a different beast altogether).

Just because you are OK with it doesn't mean that I have to be, and every step further we take from Android, the better, IMO.
Please don't break the site guidelines by going on about downvotes. It's tedious and does no good.

https://news.ycombinator.com/newsguidelines.html
Ready to have your mind blown? SV is not the only place where businesses exist. WeWork has 14 locations in the SF area and 44 locations in NYC. I work in one in NYC, and I bet only a handful of the businesses in the building are VC funded. They'll do just fine because tech isn't their only source of income.
It sounds like you haven't given it a whirl. I've been on neovim for about about 3 years now after 5 years of native vim and it's been a complete drag-and-drop.
Reminds me of the scene in Mr. Holland's Opus where the title character rigs up a system of lights to operate with the band he's directing, so that his deaf son can "see" the music.

It makes me wonder if there is a way that we can convince the part of the brain that interprets sound to operate on signals from other senses, such that they can actually be heard by someone without working ears, like a controlled synesthesia. Way beyond my knowledge and I'm sure many smarter people have considered this in the past, so I'm sure there are reasons.
DevHints.io
It really is an interesting story. They aren't best in class in any of the metrics we think of as mattering. It's not the highest scale system out there. It's not the most durable. Or the most available. Hell it's not even particularly reliable (at least throughout its history).

It is however..simple. Very simple. It's easy to reason about. It's easy to setup. For 90% of use cases it's very easy to administer.

It turns out the market for that type of data store. Something you can apt-get install and just start dropping data into is pretty massive. I've used MongoDB on a few occasions. Usually thinking I'm just using it to bootstrap a project, but three years later it's still running because it's just good enough to keep me from moving on to something else.
> That said, it's pretty hard to make sense of when you would want non-relational dbms these days. Write-scaling is still a pretty obvious reason, though things like Citus might help here.

Personally, I find a non-relational database useful when my data model is non-relational.
I'd go with a ThinkPad X60 or T60 keyboard + trackpoint plugged in via the ribbon cable. Hundreds of them on eBay + many loyal fans looking for a modern housing.
Admittedly I have to drive 3 hours to get to the closest whitewater to where I live. But cycling is pretty easy to do anywhere. There are loads of interesting ways to exercise, I just listed ones that I happen to have done. Like I say, you sound very unimaginative.
> Communicating with Wayland clients

> Xwayland (X11) support

Is this still the only way to use Wayland that doesn't require running everything on a single machine? I still don't understand why Wayland is getting so much attention when it doesn't seem to have any native clients.
I was thinking more like the Renaissance fair today. You'd visit the fair that recreates a hack-a-thon in the late 90s.
At the fair, you'd see the old programmer at his terminal, coding in Perl in an emacs window... instead of turkey legs, you'd have Fritos and Mountain Dew...
Our curriculum is all designed from scratch by our linguistics team in house, so it will certainly be specific to each language.

However, I'm sure that as we do several languages, we will reuse patterns and exercises that transfer well. A situation to practice shopping or numbers can work the same in Japanese or German without having to reinvent it. Certainly all of our grammar drills and exercises will be customized to each language, though.

I think it's pretty important to remember as well that one of the main things here is the a lot of your time in the system is spent talking to a real human. You can get the exact same live exercise several times and still have it be pretty different if you have different tutors. It's not really possible for that large part of our system to be really "generalized" in this way. Our system is very human, not just technological.
This looks awesome - is there a way to get an offline version of this?
Google is copying GE's playbook. It's fascinating to watch this tech company turn into an investment vehicle.
The degree of engineering required to detect gravitational waves, level of precision, it’s both incredibly difficult technically, and very expensive. Unless you’re looking to detect gravitational waves we would have no reason to engage in that kind of expense and difficulty, so no fiber optics will never be that for us.
(FWIW, the parent edited their comment significantly. They made a comparison to Napoleon / kings. I didn't just say that out of nowhere.)
All of those things can, in this day and age, be somewhat usefully summarized like this:

Airplane mode!

That is to say: turn off your radio for a while and just sit down, or maybe go for a walk or a swim.

Marshall McLuhan, who was extremely interested in the nervous and mental changes brought on by network technology, wrote in 1966:

With the telegraph Western man began a process of putting his nerves outside his body. Previous technologies had been extensions of physical organs: the wheel is a putting-outside-ourselves of the feet; the city wall is a collective outering of the skin. But electronic media are, instead, extensions of the central nervous system, an inclusive and simultaneous field. Since the telegraph we have extended the brains and nerves of man around the globe. As a result, the electronic age endures a total uneasiness, as of a man wearing his skull inside and his brain outside.
You might also be surprised at how effective bear spray is. You have to know how to use it; you have to wait until the bear is close enough to you, you have to not run, you have to pay attention to wind, and you need to know a few things about bear behavior.

The nice thing about bear spray is that if you know how to use it, most or all of your bear encounters will end with the bear running away from you long before you could use the bear spray anyway.
> 2-4hrs on a road bike and I've never found it boring

Same here, which is a bit surprising whenever I think about it. Especially since I never listen to music/podcasts/anything, it's always the same place [0], and it's an out-and-back route only. But I hate driving, which seems like a relatively similar activity... no idea.

[0] https://en.wikipedia.org/wiki/Washington_%26_Old_Dominion_Ra...
s,com,&/amp,

https://www.wsj.com/amp/articles/wework-a-20-billion-startup...

Then view in "Reader" mode. Most of the major browsers have it.

Alternatively, extract the text from the page and leave the Javascript behind. The Javascript is not needed to read the text.
You’re not really comprehending what I am saying. If I create an account, never post or comment, and just browse HN from the IP in question, that account will be banned. It has nothing to do with behavior.
When SF made a deal like that with JCDEcaux, they got pay toilets.
We aren't currently hiring, but we would love to talk to you for future reference. We have many plans to scale. :)

I agree that there are a lot of features we can and will add. This is only the very beginning of what we can do to improve this process, I think. I would love to hear any ideas.
The cost is actually inline with what would be expected from a cancer cure. The NHS uses 20000 - 30000 pounds/quality adjusted life year https://www.nice.org.uk/advice/lgb10/chapter/judging-the-cos... which would be about $40,000/quality adjusted life year.

If this drug provides on average 10 quality years of life, then this would fall under the guidelines as cost effective.
Explanatory theories, frameworks and the like are always a work in progress, ergo, never complete - ref Gödel's theorems. What's standard knowledge in the future can easily be utterly incomprehensible today, thus that (being part of a theory or framework) shouldn't be taken as a necessary criteria in talking about things at a level that's more abstract than a theory (which by definition must be about the (mathematical) specifics of specific phenomena), as the parent thread does.

If, as you rightly claim, everything is just interacting fields, should it make or break the argument if the specific interaction of particular (as yet unknown) combinations of fields is as yet unknown?

It can also be questioned if an individual's thoughts are special enough in the grandest scheme of things - or if they're merely a mechanism, that seems special to the body where those thoughts are occurring. For example, moving away from humans: animals have thoughts too, yet their behavior(s) can be abstracted into proper theories (apex predator theory, food chains, etc.) backed with sufficient evidence, without much regard to the thoughts of individual creatures, or even entire species - classifying creatures as predator vs prey is sufficient to study a lot of large scale ecological phenomena.

Of course, there can be various kinds of explanations for why one feels empathy for others - evolution: humans evolved to live in groups and empathy was an asset to group-living, incentives/economic: those that show consideration for others were similarly reciprocated, etc. etc.

PS: I wrote the parent, different alias.

PPS: the dog breeding problems are very real, and I do hope a rich dog-loving American can hire veterinarians and lawyers to simply sue some of the organizations involved in setting/promoting the ludicrous breed standards (resulting in GSDs with sloping backs, pugs that can't even breed without human assistance, etc.). The difference with cows and chickens is one can find enough dog lovers to make an actual issue out of this, compared to (live) cow lovers or (live) chicken lovers.
It's not hip anymore, but it's still relevant. A company might need to be hip to hype up their technology at the initial stage to gain audiences but eventually they need to settle on a mature business model that might not seem exciting but would let the company survive.
> The only reason Instagram isn’t a $100B company in its own right is because Facebook had a better vision for it than investors.

What has FB done with it that was so great, though? IMO Instagram's user experience has declined since FB bought it. I personally don't like Stories, though I understand why many people do. The timeline used to be strictly reverse-chronological, and now it's a useless mess like the FB timeline. It's also peppered with ads, which I hate. Nowadays I use Instagram a lot less than I used to.
HN and CNN are different mediums, use different designs, and have different limitations. As such I have different expectations of them.

I'm starting to lose my patience with you. I think you are intentionally being obstuse and I don't appreciate it.
Coffee in general is a lifestyle choice. Not disagreeing with you just saying that in my opinion everything about coffee is lifestyle.