skysight-inc/HackerNews huggingface dataset:
Protein staining in the study of Alzheimer’s disease is a common (and old) element of its analysis. This is part of how we identified tau protein plaque formation as part of the disease.

Prions are not part of the disease. They would stain, and be visible on microscopy. They are exactly the (type of) substance that has been stained for, and are more than large enough to show up on the various types of microscopy regularly performed on these tissue samples.

I’m trying to find a more explicit way of saying: these are easy to eee in exactly the ways that we examine these brains, so no, it’s not a prion disease.
I think it's far more likely that you are lame now.
I think the bias of this article against the cameras is obvious. I never thought the purpose of body cams were to improve police behaviour by some psychological effect (though a great benefit if it does), but to provide a record of what actually happened. They are also about protecting officers when they use force that is justified, or other situations where the need to defend their actions.
Filtering tweets based on bad language sounds like an easy user-based-configuration.

Do you think that Google's search results should contain pages with foul language or hardcore pornography? Or are you OK with Google's "safe search" functionality, which defaults to "safe"?
Well then quit acting like a bigot.
Some shoes have limited editions where only a specific number of pairs are manufactured. e.g. Yeezy Boosts by Adidas. They are Kanye West's design and very exclusive. So when they go on sale they run out within seconds. Most of the people who buy them then put the up for auction on other sites like eBay where they can fetch up to 20 times the price.

So people who want them have to get them quick so they need automated scripts that can add to cart, fill in credit info and check out the moment they are released. (The manufacturer usually announces in advance exactly the date and time they will be released).

People pay a lot for these bots. I once wrote a bot for somebody off Craigslist for a certain clothing brand that was selling exclusive jackets and shirts like this. ( I do a lot of automation and scraping for my day to day work so it was not difficult). The guy paid me $600, didn't even try to negotiate downwards. The bot bought 10 items (max allowed in the cart) at like 250 each. I looked the items up on eBay sometime later and they were going for slightly above 1k. So I actually felt I could have asked for much more.

Anyway, long story short, people put a big value on exclusivity and brand so they are willing to go to lengths to secure these limited items.
A complete cadaver does require some organ of humility however.
Create-react-app recipes
Cara Daftar Judi Poker Terbaik – QQ Dewa Poker 99 – Online QQ Poker
> in practice police, prosecutors, and judges all too often don't treat it (or even actual rape) seriously.

You might have more experience with police, prosecutors, and judges than I do, but in my experience this isn't the case. I've known many to be dismissive of drug crimes and even property crimes, but sexual assaults and rape are both addressed earnestly.

That's not to say that sexual assaults and rapes are not nolle pros'd and often. As recent events demonstrate, unless people feel comfortable coming forward, then it is impossible to prove the case. The Confrontation Clause is an obstacle that is difficult to overcome in these cases without a profusely willing victim.

This is to say saying that law enforcement is the problem is an oversimplification.

> With regard to judges, the Stanford rape case is the banner example recently; but earlier in the chain the fact thatany departments collect but then do not process rape kits is a huge problem.

In a lot of states, crime labs are independent of police departments. There are severe backlogs because they are understaffed. If you want more processing, you need to ensure your state representatives properly fund these bodies.

Consequently, it's not up to the police in many cases when and if a rape kit is tested. Thankfully, there are organizations like SAKI[1] that are pursuing rape kit testing reform in many places where there are impediments to testing these kits.

[1]: https://www.sakitta.org/
> Price is volatile, depending on weather and season

Not sure why you think that is a problem. Emissions depend on weather and season. It would not be a market if it didn't react to relevant aspects of reality.

> price per metric ton should be $50

There are too many certificates, agreed. I wasn't surprised to read that Parliament advocated stricter rules.

> Politics - elections, growth, and other factors play a significant role in setting cap and price.

I don't find that in the article. It does say that the Commission screwed us over by empting airlines, but well, that's what we expect from the Commission.

Anyway, so far I'm not convinced about the alleged loopholes mentioned above. The system doesn't work as an efficient market, that is true. As far as I can tell, that could be fixed by stricter caps.
I'm not sure what you mean by "amazingly, it looks like they still use Sanger sequencing". Sanger is considered gold standard-- all HTS genome methods are validated against it.
Actually it's mostly on niche stores that sell limited edition items like Yeezy Boosts, Supreme, BAPE. They even do it for clothes now. They have a release date and time and sell out within seconds
> For seven months, just over a thousand Washington, D.C., police officers were randomly assigned cameras — and another thousand were not. Researchers tracked use-of-force incidents, civilian complaints, charging decisions and other outcomes to see if the cameras changed behavior. But on every metric, the effects were too small to be statistically significant. Officers with cameras used force and faced civilian complaints at about the same rates as officers without cameras.

...

> Another possibility is that officers without cameras were acting like officers with cameras, simply because they knew other officers had the devices.

Or it also causes organisational changes. You can imagine the kind of things high-ranking officers will be telling their reports if they know things are going to be recorded.

Is the problem a few bad apples? Or is the problem training and discipline? If it's the later, then cameras can probably do a lot more, by scaring the Inspectors into doing their jobs properly.
Top Data Mining Algorithms, Explained(2015)
Human death is an industry and cemeteries are some of the players. Cemeteries would be obsolete if all humans had evolved the habit of cremation instead of isolated burial. Cremation costs zero units of space, isolated burial costs a finite amount of space in a world with scarce space.

If the market prefers isolated burial, then there's a market for space-consuming cemeteries. This probably costs a lot in government regulations, so cemeteries have to be big enough to absorb the initial costs.

Cemeteries are kind of a dumb idea and part of a backwards industry, driven by some silly need to bury people in quaint suburbs of death.

That sentiment is my bias showing, but it's kind of a no brainer: cemeteries are superfluous and are basically societal debt at this point. Let's hope we can count on people to move towards more economically friendly means of disposable:

1. Dump your dead friend in the woods.
2. Dump your dead friend in the ocean.
3. Dump your dead friend's ashes somewhere.

These are all better options than hogging some space, digging a hole, dumping your dead friend into the hole, then telling everyone that this land forever belongs to someone who can no longer use it.
Fuck amazon so hard. Wait... after they deliver my pumpkin carving kit.
> a system that had a hardware EFI variable reset button

Ooh, that sounds useful for hardware hackers. What was this?
> people describing things as beautiful in an objective way

All people who have passed a certain intellectual threshold recognize that when another person says "beautiful" or "lovely" or "right" without giving reasons, they're expressing a personal opinion, although perhaps one informed by years of experience in a particular field.

It's not necessary to preface every opinion with boilerplate signifying that the writer is a human being with a limited perspective and that the opinions they express aren't intended to be absolute pronouncements on the nature of objective reality. It's understood.
Wow this article is pretty condescending towards the biotech scene in Europe...

I'm going to go out on a limb here and say, maybe there are fewer biotech startups in Europe because profiting off of people's illnesses is generally frowned upon?

My guess is progress in that area falls more into the realm of government grants, with maybe the exception of classical pharmaceuticals (there are plenty of old companies like Bayer).

Biotech is not my field so I'd be interested in hearing other people's opinions.
Um, excuse me. This is hacker news, not poetry masturbation corner.
Near-permanent coherent identity continuity
I thought you were completely dissolved to the core making some kind of primordial soup, it was beautiful, until I read there are still bones at the end they can put in an urn. Could be better. The device is still worth it. Maybe the 500k model can do it?
I like the fact you go into the sewage system or be used as fertilizer (if you are a pet). At the end, you can be drunk or eaten by other people.

Only beaten by: A/space burial to the sun or frozen in the middle of total vacuum B/cryo C/science.

Btw, it's the mobile version of the page. Here is the full one: https://www.nytimes.com/2017/10/19/business/flameless-cremat...
Hak5 Packet Squirrel – a pocket sized man-in-the-middle
He could go and join Gab with all the other scum.
Despite having better internals, none of my smart phones have felt as well designed as the original Droid, that had the sliding keyboard, solid metal case, and bevel that did a lot to stop fall damage. My current phone even has a similar size screen to it -- the only feature difference is that my current phone is thinner and every other feature is worse.

If anyone knows a smartphone with that style of physical keyboard, rugged style, and good battery please tell me.

I'll trash my cheap, thin piece of plastic and buy one instantly!
Yes - reason being it’s not a signature and chargebacks happened.

This was a long time ago btw.
Ha! You're Max Woolf! Awesome, I have heard good things about you. I might want to pick your brain on something one of these days :)
Impressive how HBAL199 has been able to hang out over the island. I guess that's by altitude changes into different winds?

https://imgur.com/a/OuC3r
Individual liability of all the shot-callers. When you have to worry about jail and losing your yacht, you'd be more vigilant.
Well, when the president praises Nazi's as 'very fine people', what do you expect? Also, when the European far-right whips up fear and bullshit beyond all proportion against groups of the EU's own citizens, what do you expect?
PS3 for the most time allowed people to legitimately run an other operating system on it, so these was less of an incentive to build ‘jailbreaks’ and cracks.
20+ Free Press Release Distribution Sites and Results
The iPhone 5C models with colorful plastic backs were on the market less than 5 years ago. They also make a rose gold iPhone now which isn’t my cup of tea but Apple seems to be opening up to exploring more color options these days.
There's also a short YouTube video trailer about its functions: https://www.youtube.com/watch?v=R0xEnIXCl2g
Designing for customization with readily available third party accessories is a design choice, and one that reflects a different consumer products ecosystem than existed in the mid 20th century. I don’t mind starting with a minimalist phone and then adding my own splash of color or protective bevels. And a benefit of this system isn’t just mass customization. I can give a used phone to my mother or my son and they can re-customize it with a new case appropriate to their needs. I have no desire for someone at Apple to take away my choice of case.
The introduction is misleading about what tradeoffs it makes

>>> from bounter import bounter
>>> bounts = bounter(size_mb=1)
>>> bounts.update(str(i) for i in xrange(1000000))
>>> bounts['100']
0L

should give 1. The description should be more upfront that you are getting inaccurate answers.

> Bounter implements approximative algorithms using optimized low-level C structures, to avoid the overhead of Python objects.

"approximative algorithms" isn't a commonly used phrase (at least according to Google) and this sentence doesn't say anything about what the actual trade-off is (loss of accuracy in the counts). A possible alternative would be writing to hard disk so what trade-off is made isn't obvious.

I also don't know what the precision and recall percentages in the example table mean.
That makes a number of assumptions.

1. That wealthy people's money can dry up.

2. That wealthy people know this and it provides an impetus to spend.

3. that that impetus to spend is constructive.

4. That poor people, promised basic income, will differ markedly from wealthy people in this respect.

I can't speak to all of these but I can speak to some of them.

1. Certainly wealthy people may lose their wealth. But most don't.

https://blogs.wsj.com/economics/2016/05/19/the-wealthy-in-fl...

https://www.washingtonpost.com/news/wonk/wp/2014/10/18/poor-...

Also see this swedish study which indicates that wealthy kids save less then their parents but still tend to be wealthy, and that this is true for both adopted as well as natural born children, indicating that it's not some sort of genetic advantage
http://www.nber.org/papers/w21409

as for 4, I think you have this idea that poor people are poor because of intrinsic characteristics. This is a more common belief among conservatives (http://www.people-press.org/files/legacy-pdf/1-23-14%20Pover...).

Here's some evidence that it's not an intrinsic quality.

https://www.nytimes.com/2015/05/04/upshot/an-atlas-of-upward...

There's also evidence from things like free meals and early childhood education. Links are probably easy to search for if you google free lunch benefit and HeadStart benefit. Basically giving kids proper nutrition and free preschool make a big difference.

There aren't a lot of studies on giving adults help to get out of poverty though. People like helping kids and young adults, but once you are grown up you are kinda out of luck. I think there is some micro loan data out there though. That said there was canadian basic income, which showed only modest decreases in hours worked, and better health outcomes overall.https://en.wikipedia.org/wiki/Mincome

But even if basic income only effects children of poor people and not the poor people themselves, it seems like it could provide a marked difference in a generation.
I have many but I'll tell you this one.

I once worked on a building that was essentially ruled by the office manager (henceforward to be referred to a the wicked witch, WW for short) of one of the buildings companies. The building manager would physically shake everytime she was near.

Anyway to cut a long story short I went to the toilet without asking (yes you heard that right) and came back to find this WW at my desk basically vibrating with righteous rage. An argument ensues which ends up with WW storming off to make a complaint about me going to the toilet and my "bad" attitude which according to WW left to whole building insecure.

Up comes the building manager. I had to call him when I needed the toilet from now on.

Anyway I had noticed that the vast majority of the employees of the office WW managed had invalid passes, they were meant to have photos and employee numbers, but practically all had worn away. So I started to do my job "properly" as per the instructions set forth by WW. Every one with an invalid pass had it removed and they could not get back to work, WW was called to verify identity and she would just give them their pass back and allow them in. WW was not impressed. This lasted until lunch when no one got back into the office. They were queuing out into the street. WW was livid and tried to publicly ridicule me, just a lowly security guard messing thing up.

By the end of our second argument during which I was overly polite in tesponse to the screaming banshee the WW had turned into it was obvious she had lost.

End result. All employees allowed back into work after reissue of invalid I'd cards, I was allowed to go to the toilet when I wanted, I was sacked from that building that evening.
You should go back and reread the entire article. This isn’t a US is better than the rest of the world post, it’s a Boston/SF are getting really good at the whole life science startup thing.
Show HN: See data flow from JavaScript code to the DOM
I have never heard of anything like the following, but here is a reasonable yet very much theoretical explanation for what you described:

This virus loaded itself somehow at early bootup (maybe even launched via an altered bootloader) and then sequentially accessed every single sector on the disk and deliberately marked it as bad at either the FAT32 or ATA (hardware) level.

The bustlework involved with actually issuing tons of such ATA commands could explain the thrashing.

Ref/inspiration for this theory: ^F for "--make-bad-sector" in https://linux.die.net/man/8/hdparm

(Just to be redundantly, obsessively clear, this parameter is several orders of magnitude more dangerous than "rm -rf --no-preserve-root", as hdparm will use ATA/SCSI commands that will be preserved by the hardware across infinite reboots until exactly the right --repair-sector command is issued.)

And FWIW, I do see a lot of holes in this (very simplistic) interpretation, and would be genuinely stunned if this is what actually happened.
Keybase: PGP encryption made easy
Using Java 9 Modularization to Ship Zero-Dependency Native Apps
Yes but the problem with sky burials are the environmental contamination of leaving hundreds of bodies (or whatever remains after the vultures have their supper) to slowly decompose in one single spot. You can easily google for images of typical Zoroastrian "Towers of Silence" and see that quite a lot of stuff is left over, which the villagers just sweep off the ledge into the center hole. The idea that the corpse is "picked clean" is really debatable and demonstrably false in many cases, as you can clearly see in the images of Towers of Silence. I don't pretend to be privy to the facts -- and perhaps someone will correct me with a citation -- but from my understanding, "environmental contamination" is often one of the arguments against allowing the construction of Towers of Silence.
> were pretty uniformly proud of the job they and their men did

Individually, I'm sure there's plenty to be proud of. But as a group, they did a lot of terrible and evil things extremely well.

Since starting that documentary, when I've been thinking about large protests, I'm struck by how often the protestors are right. I know going forward it's going to change how I see big protests.
Show HN: Hasmin – A Haskell CSS minifier
> My understanding was that that was only in the beginning, when the system was introduced. Businesses that previously polluted for free could continue to pollute for free for a transitional period. I may be wrong.

You are wrong:
https://ec.europa.eu/clima/policies/ets/allowances_en

The free allowances are declining slowly, but there's no plan whatsoever to discontinue them.

> Do you have a good source to read up on this?

It's a complicated issue, but roughly things like this can happen: You can get extra certificates if you can show that you funded some kind of climate project somewhere outside of the EU ETS. This is called Clean Development Mechanism.

Then you could do something like this: fund a particularly bad industrial plant that creates severe emissions of highly potent greenhouse gases. Then you create a CDM project to reduce these emissions again. You get emission certificates for a plant that you only built dirtier in the first place.

Plenty of such schemes have been done in combination with HFC 23 (a very potent greenhouse gas that gets created in some industrial processes), wikipedia is a good starting point:
https://en.wikipedia.org/wiki/Clean_Development_Mechanism#De...

For HFC 23 this loophole has been closed. But there are plenty more such problems.

Further reading, there's an NGO focused on such issued called Carbon Trade Watch: http://www.carbontradewatch.org/

My examples are a bit dated, because it's been a while when I was following it in detail. But it's a weird system that's so corrupted by lobbying that it hardly does any good.
> Waves and spirals

Like "swings and roundabouts"? I've never come across this variation.
Suggested build over Intel Core i7-7700K below 2000 USD
So Twitter is big because it's big?
Not going to discuss specific stories for confidentiality reasons, but when I was a security guard, bad clients only had two things to say:

When things are fine: "Why are you in the way, doing X?"

When things aren't fine: "Why didn't you do something?"

Nevermind if the X they explicitly tell you not to do is related to stopping bad thing.
I never saw yours either (is it a common saying ? I'm not a native english speaker anyway, that would explain that).
Experience with an incorrectly heatsunk laptop GPU has demonstrated to me that the BIOS will yank power to the system if it hits 100°C.

Yeah.

Well, in all honesty I'm not sure if it was Linux, the BIOS, or some low-level thermal monitoring circuitry, but yeah, I one minute I was messing around with WebGL and the next minute I got confused about whether I'd forgotten the power cable. (Then I realized I hadn't heard any beeping (this was a ThinkPad and I didn't have the beeper muted) and realized it had overheated.)
Still, the choice should be there for those who prefer the rubber shell phones.

And no, devices like the Cat S60 don't really count. They are abandoned basically the moment they leave the factory. It's questionable if you'll see a software update on that device, like ever.
Honestly I've been planning for a good old-fashioned Roman funeral pyre after I'm gone. Complete with some kind of monument with an inscription imploring passersby not to shit on my grave.
You don't always have to.

For example, I use a CDN for some of my assets, except for users in the EU.

It turns out, for users in the EU I can get faster speeds with my own systems, for almost two orders of magnitude difference in traffic pricing.

If a large amount of your users happen to be in such a region, it might even make sense to use no CDN at all.
Yeah, like, those are actually the extremist groups with ties to terrorism that this kind policy is designed for. It’s not Twitter’s fault that mainstream politics has gone haywire... I mean maybe it is, but point stands
Why and how I unsubscribed to 163 newsletters in 10 minutes
Most of security instruments (guards or metal detectors) are made for shows and to make people feel secure. If you want to break into the building, just bring your friend and arm yourself with an AK-47 and kill the motherfuckers~.

~Just kidding. Don't do it.
Any insight on the possibility of transmissible amyloid pathology? http://www.nature.com/news/the-red-hot-debate-about-transmis...
> as phones got bigger I don't see many sites utilizing responsive design so that I can still use my phone with one hand.

Is 6.5" or 7" a phone such as the Galaxy Note, to be used with one hand?

Or is it a Nexus 7, to be used with two hands?

If you buy a tablet or phablet — a device larger than 5" — you'll have to expext that you'll have to use it with two hands.

You can always buy a smaller device if you prefer to use something else.
Show HN: Rebuilt nevercompletedgame.com using domain-driven design (DDD)