skysight-inc/HackerNews huggingface dataset:
> It wasn't until Celera started embarrassing the NIH effort that shotgun sequencing was taken up in earnest.

Sure.

But I disagree with the overall premise and think you're over-simplifying in the extreme. What really made the Human Genome Project possible was the Moore-like curve in sequencing throughput that occurred throughout the lifetime of the Human Genome Project. There were many contributing factors that kept the curve going (including the other Moore curve!)

Also, Sangar never got a Nobel in Medicine (just in Chemistry). So even if shotgun sequencing is the idea that deserves the Nobel for Human Genome Project -- which again, isn't exactly an incontestable assertion -- then it's Sangar, not Venter, who was robbed. Awarding Venter with a scientific award for his political work pushing Sangar's science would be an odd choice, not to mention at odds with your apparent overall feelings about the role of politics in Nobel awards.

Which... maybe they both deserve a Nobel for their contributions to the Genome Project. Probably so, in my opinion. It's almost like the supply of Nobels is artificially constrained and not everyone who deserves one can get one...

> Later, his idea of then taking shotgun sequencing and applying it to whatever DNA you could find floating in the Sargasso Sea or any random teaspoon of dirt literally opened a whole new world of evolutionary biology.

Lots of people use shotgun sequencing for all sorts of high-profile and important stuff that is literally opening a whole new world of all sorts of important fields.

And there's a lot of stuff going on outside of genetic sequencing that also deserves Nobels.

> Finally, his more recent work on creating a fully synthetic organism is continuing to push forward the bleeding edge of biotechnology by laying a foundation all of humanity is sure to build on for decades to come.

So maybe a Nobel will be awarded in the decades to come. Nobels are given for impact, not promise, and impact takes decades to accrue even for the most impactful work.

I would never say someone like Venter "doesn't deserve a Nobel". But getting all bent out of shape that he doesn't have one is kinda weird, especially since he's not exactly starved of other sources of recognition -- both inside and outside Academia -- for his contributions. Lots of people who played outsized roles in the Human Genome Project exist in relative obscurity relative to Venter. Which isn't to say he doesn't deserve his recognition, but I just don't understand the particular drum you're beating here.
I guess this is Github's issue then? Things should settle down in a few days, it might just be having trouble with the HN traffic.

I'm not very well versed with the web, what does 'bundle.js?<anything>' do? Will adding that to my code solve the problem?
Convoy | Software Engineers | Seattle, WA | Full-Time | ONSITE

https://convoy.com

Help us optimize trucking and logistics - a $800B industry that still runs on fax machines and phone calls.

We would love more engineers, up and down the stack, and anywhere on the generalist <-> specialist spectrum. We use pretty cutting-edge tech (React, React Native, TypeScript, Node, GraphQL), but we're more interested in engineering chops than any particular tech skills.

I've been here since the beginning (over two years now). The team has grown quickly, but we still have a tight-knit and incredibly smart group of engineers. We have an endless supply of interesting problems including machine learning, service architecture, mobile/desktop/web UX, complicated business modeling, and much more.

Some of our backers include Y Combinator (Continuity Fund), Jeff Bezos, Bill Gates, and Greylock Partners. You can read more about us:

http://www.mosaicventures.com/mosaicblog/2017/7/25/our-inves...
https://www.theverge.com/2017/7/26/16027650/convoy-trucking-...

If you're interested in hearing more, reach out and grab coffee with me or one of our other developers. Help us grow an amazing tech team from a very early point in our company's history!

http://jobs.convoy.com
Nice try Mr. Smith...
The New York Public Library | Android/iOS Engineer | Full-time + On-site in NYC | http://www.librarysimplified.org

The New York Public Library is reshaping the world of e-books and library lending with its SimplyE and Open eBooks mobile applications. Our small, dedicated, and compassionate team is looking for an exceptional mobile software engineer to help us in the quest for ever greater public access to information. Join us in our efforts at the main NYPL branch location (of Ghostbusters fame) and you'll experience the pleasure of working full-time on open-source software, enjoy a healthy work-life balance, and sleep well at night knowing you're doing what's best for library patrons, not someone else's bottom line.

Our native apps are written primarily in Objective-C and Java with new development being undertaken in Swift and Kotlin. We're looking for an Android or iOS expert who is eager to eventually contribute on both mobile platforms. You should be competent with Git, know a thing or two about SQL, and understand the basics of JavaScript and DOM manipulation. Knowledge of the EPUB format, familiarity with building accessible apps, and a good understanding of functional programming are major plusses.

Ready to improve the experiences of library patrons around the US? Send your résumé to "info@librarysimplified.org" and let us know!
Tapad | Unify Life Across Devices | Onsite: New York, NY or Oslo, Norway | $100K - $160K/YR + Bonus

Tapad is the true cross-device partner. By leveraging the power of our proprietary Tapad Device Graph™, we unify data across all devices to understand the interests, passions and behaviors of the audiences that matter most.

Tapad's Open Source tech stack (below) handle:

30+ PB of Data,

Sub 10 ms response times.

___________________________________________

Distributed Applications... Scala, Python

Distributed Computing... Mesos, Kafka, Zookeeper

Distributed Databases... Aerospike, Cassandra, Vertica

Distributed Analytics... Hadoop (YARN), Spark 2

Distributed Storage... Ceph, Hadoop (HDFS)

Global Networking... VXLAN, BGP, EVPN, VPLS

Here are our open roles in Engineering:

Data Scientist (NYC) - http://grnh.se/6c1pdb1

Site Reliability Engineer (Oslo): http://grnh.se/hadlum1

Senior Software Engineer (NYC): http://grnh.se/5giaqb1

Senior Software Engineer (Oslo): http://grnh.se/v4bnl51

Senior Director, Solutions Engineering (NYC): http://grnh.se/801s3q1

Senior Solutions Engineer (NYC): http://grnh.se/4mxjky1

Summer Internship (NYC): http://grnh.se/l78ofb1

Summer Internship (Oslo): http://grnh.se/6lvijp1
EDITED | Engineering Positions | London, UK | Onsite | Full-Time

We’re currently hiring for front-end, back-end, data scientists and DevOps Engineers. Our stack is primarily Python & JavaScript, with frameworks like Django/Flask and react.js/d3. We aren’t afraid to integrate new tech and like to keep exploring what’s out there.

We're an established startup, focused on doing important things for retail, the fourth biggest industry in the world, helping them reduce waste and be more efficient. We have a beautiful web app, used everyday by hundreds of people at Topshop, Saks Fifth Avenue, GAP and more.

Our engineering team is a group of smart people from really varied backgrounds. We’re solving diverse and interesting problems on a daily basis, like image analysis, big data visualisation and a load of other fun things that come with having a rapidly growing data set. We love good practices like extensive testing and continuous integration, and enjoy giving back to the community, so open source contributions are highly encouraged.

Our office is large and sociable; people eat lunch together every day and we have drinks and snacks in the office every Friday, as well as team days out and all expenses paid trips abroad. There’s a video on our jobs page of our most recent one: http://edited.com/jobs/

Half of the team has actually found and joined us through “Who’s hiring”, so don't hesitate to get in touch, we're always happy to meet new people!

See here for more details about current vacancies and to apply directly online: https://edited.com/jobs/engineering/
Have you tried exercising before work? I've been doing 1hr to 1.5 hr runs before work once a week and I'm always relatively sleepy by the time the sun goes down those days, as long as I haven't had caffeine after 2ish pm.
"I don't think it's particularly controversial, that static typing in general has advantages"

That's not really true, just a belief. I give you an example to start understanding these things: the exact same program written in a very high level and very expressive language, like Perl, instead of Go, is going to have at least 3 times less code and since defect rates per line of code are comparable, you would end up with at least 3 times less bugs. Suddenly reliability argument of static typing doesn't make any sense. That's because in PL research there is a huge gap in understanding of how programmers actually think.
A dark magic mouse and keyboard at the very bottom of the page. Thats new.
CRITEO (http://labs.criteo.com/) | Paris, France | Full-time ONSITE | Machine Learning Engineer (VISA sponsorship)

• Click prediction: How do you accurately predict if the user will click on an ad in less than a millisecond? Thankfully, you have billions of data points to help you.

• Recommender systems: A standard SVD works well. But what happens when you have to choose the top products amongst hundreds of thousands for every user, 2 billion times per day, in less than 50ms?

• Auction theory: In a second-price auction, the theoretical optimal is to bid the expected value. But what happens when you run 15 billion auctions per day against the same competitors?

• Explore/exploit: It's easy, UCB and Thomson sampling have low regret. But what happens when new products come and go and when each ad displayed changes the reward of each arm?

• Offline testing: You can always compute the classification error on model predicting the probability of a click. But is this really related to the online performance of a new model?

• Optimization: Stochastic gradient descent is great when you have lots of data. But what do you do when all data are not equal and you must distribute the learning over several hundred nodes?

Missions of the team in more details: http://labs.criteo.com/wp-content/uploads/2015/04/Software-E...

Feel free to drop me a line at n.rassam[at]criteo.com
One small missing feature I noticed is when I have my cursor over a parens (or bracket, or brace) it does not highlight the matching parens.
https://emailoctopus.com | LONDON | ONSITE

We're a bootstrapped (and profitable!) startup offering mail marketing for up to 10x cheaper than MailChimp. Looking for an onsite PHP developer to join us - experience of AWS essential.

Email jonathan [@companyname] .com
Google Home is quite good though.
We are in the process of rebuilding our app in react native. As a test, we created a portion of it in react native and did a side by side.

Our app is your basic slide out navigation with pages and forms and some animation. There is literally no detectable difference.

The only thing that I am still not sure of is performance on older devices. But on iPhone 6 and Galaxy S7... I wish we had started with react native from the beginning.
> constitutional protection against tyranny

The idea of a right to armed revolution is the whole problem. This is indistinguishable from terrorism.
Exascale Computing to Accelerate Clean Fusion Energy – InsideHPC
Personally when I take melatonin, I fall asleep quickly but I get weird dreams and I feel my sleep quality isn't the same. I took it for a little while (a couple of months) and now only take it when I'm really struggling to fall asleep.
Bring MacOS “Quick Look” Feature to Windows
LitCharts | Front-End Developer with Rails experience and strong design/UI/UX skills | REMOTE (USA) | https://www.litcharts.com | Full Time

Come help improve literature education with LitCharts! LitCharts provides high quality literature guides, analysis, and related literary tools and resources. Over two million students, teachers, and general interest readers use the LitCharts website and mobile apps every month.

We're looking for someone to help design and implement our front end. HTML/Haml, CSS/SCSS, jQuery/javascript skills required. Design/UI/UX experience would be ideal. Must also have experience and be comfortable with Ruby on Rails.

We’re a small team, and the code you write will have a direct impact on our success as well as reach millions of users. You can work from home or anywhere. We work flexible hours but typically stick to 9am-5pm EST and are looking for someone able to do the same. All applicants must also be legally authorized to work in the United States.

Please email your resume, Github profile, samples of your code/work, or anything else you'd like to us to know about to hiring@litcharts.com to apply. Thanks for reading!
Correct, it's irrelevant. The scale of the universe, and where it came from, is already beyond our comprehension. We might as well just be living in a computer simulation, because ANY explanation would make just as much sense to us.
I agree actually. I'm just explaining why the person gets downvoted in other threads.
Believing that any technology has no cost is poor engineering IMO. There are costs to that rigidity, and they're rather self-evident.
not only that but if we are able to simulate life in a computer, and we are a simulation as well, then most likely those who watch us on their computer's screen might be simulated as well.

Nevertheless learning that someone simulate us does not answer the question where the live came from... because those simulating us had to have a beginning too. And if they started in a computer simulation, then who is simulating them? And so on... its truly a question that can give you a headache!
eero (https://eero.com) | San Francisco, CA | Full-time | ONSITE
We're looking for backend, data, mobile, firmware, and hardware engineers. We are also looking to hire senior PMs and designers. Our mission is to be the gold standard in Wi-Fi and to become the backbone for your smart home. Our stack includes but not limited to Scala, C, Python, React, Swift, Java, Go.
Apply at https://boards.greenhouse.io/eero or email me at jsorenson@eero.com.
I must admit I didn't know about the feral cats wandering around farms. But I do imagine that farmers wash their produce more consistently than home growers do, and that feline density is higher in the suburbs.
Yeah, as much as I like tinkering on my own machine, if someone has a machine go down at work, or gets approved for an upgrade, etc., tech support gets a call and they come drop a new box on our desk. Not enough time in the day for us to make it more complicated than that.
The author goes to lengths to explain how bash sucks at embedded null bytes in variable values (strings). But Bash is fine with nulls in pipes:

$ printf 'foo\x00bar\x00baz' | xargs -0 -n1 | wc -l
3

The real bash solution is you'd write a command to escape HTML entities, and set up the pipeline so that bash never has to assign any values that might have nulls. If I wanted a shell that was better at programming & manipulating test data, I'd use perl.
Are you all interested in remote full-time engineers? Graduate student at Cornell specializing in Deep Learning with CV experience? My email is aem336@cornell.edu
Blue River Technology (recently acquired by John Deere) | SW & CV/ML | San Francisco & Sunnyvale | Onsite

Come make smart things in big machines:
http://careers.bluerivertechnology.com
On the other hand that would basically a proof for "God" which give me a real motivation to try to communicate with those running the simulation.
Previous article's thread https://news.ycombinator.com/item?id=15291809
But how can you offer any refactoring or auto-complete inside a function if you don't know what type to expect as an argument?
Epam Systems | .net developer | Guadalajara, MX | http://www.epam.com

RESPONSIBILITIES

-Develop high quality Microsoft stack ASP.NET WebForms applications using C#/.NET, SQL Server, Visual Studio, TFS;
-Ensure that deliverables are self-certified before going to QA and customers;
-Work within our engineering process using TFS, TDD, continuous integration, and continuous deployment;

REQUIREMENTS
3+ years of experience as a .NET Developer;
Advanced SQL knowledge;
Basic JS knowledge;
Basic knowledge of Web API;
Experience working with XML files;
Strong capacity of analysis and debug;

PERKS:
-100% under payroll;
-Law benefits (IMSS, INFONAVIT, 15 days December, bonus, 25% vacation bonus, Mexican holidays plus December the 24th and 31st);
-Major medical expenses insurance;
-Dental insurance;
-Life insurance;
-13 % employee savings fund;
-Vacations starting with 10 days plus 2 floating days;
-Grocery coupons

* Send your CV: jesus_flores@epam.com
If it's exponential then even that size difference wouldn't help
Not bad. But hey there's always a chance the simulation skips the computation and just writes something plausible into the scientists' computers.
That makes a whole lot more sense.

Tangentially related: It's a bit of a strange feeling to recommend 32 GB of RAM as a base amount. My, how times have changed.
Is there no topic that you like to discuss at length, that others don't enjoy and wonder why it is important to you?
I agree with you on the media being biased (by both sides). But I don't think this should be about the numbers. I only stated that percentage to make clear the point that there was no census and multiple ways to hack the polls...

In any case, my arguments apply wether that percentage is 15 or 50.
Also, I believe we shouldn't differentiate between regions that could have the privilege of voting and regions who wouldn't have it (specially when the reasons aren't solid) , it just intensifies the feeling of false superiority and xenophobia between different populations.

I could agree on the possibility of self determination for any region (or city), but I'd like people to think a little bit more about what that could mean in the long term and if that's something good for the world overall.

Sorry again if I was too arrogant, I fully respect your love for your hometown and your people.
Healx | Full stack developer | Cambridge, UK | ONSITE | https://healx.io/

Healx is a Cambridge, UK startup using computational methods to identify existing drugs that may treat rare diseases. We have data coming out of our ears, including biological data, scientific literature and the results of our analyses, so we've built internal web tools to help our team to make sense of it all. We're hiring a full stack developer to help us find better ways of presenting the data, whether it's for pharmacologists exploring the evidence that a drug may treat a disease, or salespeople finding information about a disorder and related charities.

To apply, please email jobs@healx.io with your CV and a few words explaining why you're interested in the role.
If our universe is deterministic there's no difference between existence and inexistence.

If you have a piece of paper with seed written on it then you already have in possession any moment of history of our universe.
they assumed the real world is anything like the simulation we're living in. we might be as close to resembling the real world as flat world is to us
You can totally break some product functionality somehow without necessarily triggering a software exception or server crash! You really do need to know the target events per experiment group.
It would depend on the simulation.

Are other people still real people, living alongside you in the simulation, or are they too simulated?

(Whether there's a difference depends on one's philosophy, mind.)
Deutsche Bahn // DB Drive | Senior Android Developer | Frankfurt am Main, Germany | ONSITE | Fulltime

We are looking for great Android developers! Do you have a passion for building mobile applications? Do you love working on and shaping products, using best practices and state-of-the-art tools, developing software in a modern way? Then we should talk!

But first, who's "we"? We are a startup being founded inside Deutsche Bahn AG. Our mission is to modernise today's mobility through innovation and disruption of existing solutions. Autonomous shuttles, on-demand mobility and learning, growing, digital systems that help to shape and to change the mobility of tomorrow? Yes, we're on it and we want you to join us in our office in the heart of Frankfurt am Main, Germany!

Are you skeptical about Deutsche Bahn being able to move fast and innovate? We totally understand, but we want to tell you that we are completely autonomous and try our best to offer the best of both worlds: the benefits that come from working for a large corporation and the joy of working for a fast-moving and creative start-up that wants to ship.

Interested? Shoot me an email with your CV/GitHub/StackOverflow and a few words about yourself: thorsten.ball@dbdrive.io
I never bought into the theory, but I don’t think this is a good proof. I won’t pretend to understand the scientific details of their argument, but it breaks down if you assume that the creators live in a universe that does not follow the same physical laws as ours. Our universe may be simplified (possibly by necessity) and could be incapable of creating full recursive simulations of worlds as complex as our own, but that says nothing about the original universe that its based in.

Like any arguments about the existence of a higher being, it is impossible to prove that a higher being that doesn’t want to be found doesn’t exist. Just choose whichever theory you find to be more convenient, and live your life to the best of your ability.
So, finally can we collectively say to Ray Kurzeweil "SHUT UP AND SIT DOWN" because frankly, this is like nought for six

no, there is no uplift
no, for the third time, you did not predict ubiquitous AI around the corner correctly
no, we are not living in a simulation
You may want to consider something a little more casual. I like this breathing pattern:

https://www.youtube.com/watch?v=_Wg-UAYGa2A
Ethical egoism is not my position; I'm not making a moral claim. I agree, though, that psychological egoism is yours. And as Wikipedia explains, psychological egoism is considered tautological and lacking in explanatory power.

Given that you apparently understand that people mean different things here, your intervention in this conversation is especially irritating. Rather than just recognizing that jrs235 is using a different definition of self interest, the one that Smith was using, you post an faux-naive question, wasting at least his and my time, and likely that of others.
Hah, good to know. I guess that’s what you get for installing a beta OS on a machine you care about.