skysight-inc/HackerNews huggingface dataset:
US doctors are prescribing far more opioids that doctors in any other country. The US uses 99% of the world supply of hydrocodone, for example.

The opioid crisis is far worse in the US than in any other country.

> I don't think it's a coincidence that heterocyclic/tricyclic anti-depressants have come under extreme scrutiny. Basically--do they even work. Oh yea, that double blind study, in India, proved they work 62% over a huge Placebo response? Meaning 6 patients answered three positive questing, more that the control group, on that poorly worded psychological test.

SSRIs are good at treating depression if you actually have depression. (something like 60% efficacy) If you don't have depression they don't work at all. The lack of efficacy of SSRIs is just US doctors again overdiagnosing and overtreating.

The theme is US healthcare is not very good for very many people..

> There are studies, done in nursing homes, that state that patients on opioids can stay on tge same dose of opioids for years, and don't feel the need go up their dose.)

Do you have a source? Because all the studies I've seen show that long term use of opioids causes tolerance, and doesn't work to treat pain.
To elaborate a bit on what amenghra said, the information you are asked for when you use your card for a "card not present" transaction (card number, card security code, name, billing address, expiration date) falls into three categories.

• information required by the bank,

• information that the bank will check if you supply it,

• information that is not checked by the bank.

The first category, required information, is just the card number for most banks (and the amount to charge, of course).

The second category, checked by the bank if supplied, is everything except for the card number and the expiration date and the amount. This information is used for fraud control. If a merchant supplies it, the bank tells the merchant if it was correct. With many banks the credit card fees are slightly lower if this information is supplied. Even if the merchant supplies this and the bank says it does not match the merchant can go ahead with the transaction, although such transactions have a higher risk of fraud (and therefore chargebacks).

The third category, information not checked by the bank, is the expiration date. The expiration date check is at the payment processor, and that check is simply:

if expiration_date < current_date()
reject_transaction()

The expiration date on a card is just when that physical card is no longer supposed to be used. It is not an expiration date on the underlying account.

This is one reason why many people have gotten a surprise when they have had some kind of subscription they no longer wanted, and instead of actually cancelling it they just let their card expire and think the re-billing will then fail. There are three problems with that approach.

1. If the merchant marks a transaction as a recurring transaction some payment processors skip the expiration date check.

2. Some merchants include something like this in their re-billing code:

if expiration_date < current_date()
expiration_date = date_add(expiration_date, interval(3, 'years'))

3. Visa, Mastercard, and Discover (not sure about Amex) have updater services. Merchants can send a credit card number and expiration date to the updater service, and the service will tell them the current expiration date and the current card number for the underlying account. This one can be especially surprising to people because it can update both the expiration date and the card number.
London tried exactly this post-WW2: https://en.wikipedia.org/wiki/City_of_London_Pedway_Scheme
My style guides to avoid this:

- Only use {}-free object literals in assignment

- Always add () to nested single-line function calls, and calls with expressions.
> The 'cost' of doing drugs in society right now is pretty dam high. Social stigma, the possibility of going to jail, various professional licences lost.

Is it? I've never heard of anyone who wanted to try drugs and was unable to get them. Maybe it's different in the US, but in Europe, you can always find a supplier.
Sorry but if you cold emailed this to a VC, it makes sense that you didn't receive an answer. It's a rambling wall of text packed with irrelevant technical information. I now know your tech stack, infrastructure and the text editor you use, but I still have no idea which problem you are trying to solve. All I know is that you're doing some kind of applied math that you don't want people to call AI.

Instead try to look at your cold email like a pitch. If you apply the advice from OP, I'm sure this post will be much shorter and actually explain the product you are building and who the customers are.

Also, a pitch is two minutes. This post took me forever to read.
One Leak Will Sink a Ship: WebRTC IP Address Leaks
It no longer has a hard dependency: "since Signal 3.30.0 that is not a hard dependency anymore." [1].

[1] https://copperhead.co/android/docs/usage_guide#signal
Amazon has free returns for now as only a tiny minority uses that as an option. Also returns work largely if there is a defect or you genuinely bought a wrong product(Like a wrong shoe size).

If most users start doing returns, they won't be free or even possible, given how much logistical nightmare that will be.

Beyond all this, that turn around time to buy a single product will be high.

Stores offer a good middle ground, and you can get a good hold of things before you actually make a purchase. I'm not saying toy purchase or any other purchase online will go down, but there will be a lot of buying will be waste.
One would think they would know better, right?
I use a company called Revolut to manage a card of mine. One of the options in the app is to explicitly disabled Magstripe payments, so one wonders if you could ask your bank to disable it?
You can't be a criminal gang that murders people to smuggle the drugs into the country.

You can't be a criminal gang that forces modern slaves to grow cannabis in squat houses.

You can't be a criminal gang that uses violence to control a street corner.
Interestingly, I have been traveling in Ireland recently, and well over 90% of my transactions are Apple Pay.
> In fact, JMLR, Inc. didn’t even have a bank account until recently; there was no need.

Heh. Those Elsevier and Springer profits look gross but from the other direction. What are they doing with all that revenue?
Every single manned space flight since the beginning in the 1960s has been more or less automated. Some early landings and dockings were flown manually but even those are mostly automated now.

It's not really a cost saving measure, it's just that machines are much more capable of performing the precision maneuvers it takes to fly spacecraft under normal conditions.
Former defense contractor here. I trust Microsoft to have put more time and money into making that controller maximally usable and useful than whatever subcontractor would have made the thing otherwise.
A proposal for readable cryptocurrency addresses in DNS
> that takes years of training is a dead end profession.

The sky's the limit!
I've worked on HyperPHP / HipHopPHP (HPHPc, known by a million different things in its lifespan) in the past doing a lot of documentation and edge case testing. I absolutely loved the compiler, turning PHP scripts into C++, and running it through its paces using ANN libraries. I have a lot of love for the project and was onboard very early in the lifecycle. I really, really miss it. I thought it was a great learning tool.

Anyway, it's proven that without competitors to Zend Engine, the PHP team simply doesn't care to pay much attention to performance. (Snide comments about performance from maintainers and internal PHP contributors can be found all over the Internet to prove this point.) I am afraid this will continue as HHVM splits from PHP and moves more towards a JVM-type future.

Hack will be the "serious" language while PHP7 will serve a solid niche, and one I'm continually proud to support and use in production.

Nuclide works well enough with Hack and the typechecker is really solid.

I'm excited to see the future of both projects, but again, it is important to note that HPHPc by Facebook pushed PHP's project team into caring about a lot of this stuff over the years. I hope it doesn't take that kind of disruption to continue development, as I think PHP is in a really good spot now and don't want it to stagnate.
> Get rid of the magstripe and bad
> actors will steal your card info
> using cameras

They probably won't though, they'll probably just skim people who don't do that.
> That wasn't stated anywhere in this thread.

It's an extension to your "double zipping" analogy.

> nothing can prevent the fragmentation and need for garbage collection

Nothing prevents fragmentation entirely but these tactics can decrease the write amplification by an enormous amount. If the initial comment was only saying that filesystems can't improve on what drives already do, it was accidentally worded in a very misleading way.

And are you sure filesystems can't arrange writes to make it more effective?
Traffic Titan..How to Make Money with FREE Traffic – Reviews and Bonuses
Cliff Click (Java HotSpot): Java vs. C++
Wouldn't it make more sense to take the parts of the PHP runtime environment that enable rapid prototyping and figure out how to implement them in a language that has a working == operator rather than trying to graft type safety on a language that has both strpos() and str_rot13()?

Remember BML, bradfitz' attempt to do this with Perl?

I would love to see someone do something similar for Python.
Two Powerful Updates for Applications Using Bluetooth or 6LoWPAN
Care to share how you do this? Last time I tried, my self compiled Signal wouldn't work with Signal's servers. I just assumed I needed some sort of key. Perhaps my problem was something else?

A self built Signal would go a long way to be usable for me. One that didn't depend on Google Services would be even better.
You've said why it is expensive. Not why it needs to be expensive.
And XP and 2000 and maybe earlier versions too
Grsecurity 4.12 Updates
> "Previously" in this case would have been four years ago, would it not? Ever since then, EME has already been reality. If EME has been reality and commonplace since then, what does this W3C decision really change?

There is no FUD here. The W3C should not be involved in standardizing DRM API. If browsers want to implement DRM it is their problems. Everybody dropped the ball here. Mozilla, the W3C ... they could have just said no, that's not our problem, they were too corrupt to do that, they just signed the death of the open web.
Maybe ':' would be a more familiar separator because of hours, minutes and seconds (yeah, hours don't go up to 60, but whatever).
I can easily believe that.

Next time you're sat in a meeting with 5 other highly paid software developers, discussing a two line bugfix, think about how much that bugfix will have cost.
Everyone else answered your questions/misconceptions about Laravel, but Laravel owes a lot of its popularity to Laravel Forge [0] and the tooling around deployment and code management. It is a tremendous tool.

[0] https://forge.laravel.com/
That's not degraded only for Linux. The 720p limitation in Chrome and Firefox is also there for Windows and Mac.
With all those controversial statements Moxie was making and questionable decisions in development Signal lost its initial attractiveness and, in my opinion, relevance. Even Wire opened their server-side source code by now (not that Signal hadn't). While this was happening, we got Matrix[0] and GNU Ring[1] in a usable state, and I can't see any reason to use Signal (let alone Telegram) any more.

This is all very unfortunate, because the success of this type of services depend strongly on its initial user-base size. For a while, with the rise of mobile there seemed to appear a critical window (from the public perspective: ICQ forgotten, XMPP not even noticed, Skype annoyed everyone, Google talk ?) for a new IM to fit itself, but it seems lost. I fear enticing users to switch to the reasonable solutions, like those mentioned, is already a Sisyphean task. Don't know about you, but I'm not valuable enough contact to keep one more application installed on someone's smartphone to contact me exclusively. "Cut showing off, use what everyone's using!" Even in a rarest occasion when I manage to successively tempt anyone, with the first bug or UX flaw they jump ship and become even more opposite to the idea of trying what's supposed to be a better solution.

[0] https://matrix.org/

[1] https://ring.cx/
Does "lifetime use" mean "percentage of people who ever tried it"? If so, I can totally see that. When stuff is legal, more people are going to try it.

However, using it once or a few times is nowhere near being addicted. And all the other bullet points in your source [0] look pretty great:

- Increased uptake of treatment

- Reduction in new HIV diagnoses amongst drug users

- Reduction in drug related deaths

- Drug use among adolescents (13-15 yrs) and "problematic" users declined

- Decreased street value of most illicit drugs, some significantly
>>Have a look at Python & Flask! There is nothing easier than that!

What? PHP is significantly easier to roll out for your beginner/intermediate junior developer on a VPS. There isn't any comparison.

This comes from someone who leans on Python hard for ML work / scraping / signal processing (what it was born to do) and PHP for web development (what IT was born to do).
The apk can be directly downloaded on their website [0]. It is signed by OWS, runs without gapps installed via websockets and should be 'auto-updating'.

f-droid would be nice, I agree. I did not really follow the whole political discussion about why moxie refuses to cooperate, but at least I can use signal again after some years without gapps.

[0] https://signal.org/android/apk/
> it's ridiculous to claim that Web Components can stop the Framework Churn when they predate most of the frameworks

How on Earth do you figure that? I'm well aware that e.g. the <video/> element is basically implemented as a Web Component in most (all?) browsers, but the reason people are excited is that it's now possible for non-browser developers to use Web Components and have those components work just like native elements.
What does the "plus" sign on a Phenom 100 panel mean?
> Nitpick: Can you actually hollow out an asteroid?

You'd probably need expertise in boring to pull it off ;-)
+1 for using KiCad to draw the schematic - it's important to use open source software when you're developing open source hardware. The licences for Altium, Eagle and co can cost many hundreds or thousands of dollars/euros/pounds a year, which bars entry to a lot of hobbyists. Improving what is already a fantastic piece of software (KiCad) is a big priority in my view. It's good that places like CERN are getting behind it.
> Shibboleth

I don't know what that is. Should I?
In what way is it not simple? It's hard to tell what you mean. The syntax is actually a bit of a nightmare if you are writing a parser, but from the perspective of a human reader, it shows you exactly what's going on under the hood.
> And yet, drugs are clearly bad

No, they aren't. There's a spectrum. Some are bad all the time, some are bad if they're abused. And I'd like to look at it the other way: some are great if not abused. Are we going to continue throw that away because abuse is possible?

> They provide excuses about why they need it and explanations of what it does for them. As an outsider, it seems like total and complete bullshit, and I don't want any part of it.

That is of course your choice, and I have a ton of respect for you for setting your own boundaries and sticking to them, as so many people have trouble doing that (myself included, sometimes!). But at the same time, I and others have different boundaries, and people like you need to stop trying to legislate what those "must" be.

I'm sick of people being told how to live their lives, especially in cases where doing so doesn't harm others. But guess what: sometimes people will harm others, and so you deal with that. Assault is already illegal, whether you're high or not. Maybe penalties for assault should be higher if under the influence of a drug, but that in no way means the drug itself must be made illegal.

I saw a cited stat in this thread somewhere that 1.1M people in the US were arrested for driving under the influence of alcohol in a recent year. That seems like a lot until you read that 111M people admitted to driving under the influence, whether they were caught or not. I'm not sure what percentage of the 1.1M arrested hurt or killed someone, but even if it was every single one, that's still less than 1% of the total. Also not sure how many of those 111M hurt anyone, but one can expect that to be a pretty small number since alcohol-related car crashes don't often go unnoticed by the police. So it's not even true that people who drive drunk hurt people even a decent percent of the time, let alone a majority. I'm certainly not in favor of legalizing drunk driving, but it's a fine example of how hysteria and fear campaigns make problems seem much larger than they are. I think that's a fine example: alcohol itself isn't illegal, but if you do certain potentially-harmful things while under the influence of it, penalties are higher.

Assuming humanity survives another 100 years, my guess is our current attitude toward drugs will be one of those things that our future counterparts will find crazy, and shake their heads ruefully at those silly primitive past humans.
> I have observed that people that I knew many years ago and that use weed daily, now have psychological problems.

That observation, by itself, does not say anything about what's cause and what's effect. It may very well be that cannabis causes all these things. It may also be that the sort of people who have psychological problems are drawn towards smoking weed either because of these psychological problems (i.e. seeing cannabis use as a relief for mental stress) or because of a common cause of both desire for cannabis and psychological problems.

I'm not saying which is true (not an expert on the subject), just that you cannot deduce it from your observation.
I do not understand DRM/silverlight properly. Does this means that I won't be able to see what code is running in my browser for eg. JS collecting data in the background or use things like adblocker, greasemonkey etc.
> That's a scary thought. Building this type of software takes a lot of money.

I'd argue that this is the point of raising investments prior to there being a product which may generate revenue.
Why US Companies Choose Ukraine Over India, China and Latin Countries
>The first item on the list is written in an interpreted language.

Could I see the code? Because I'm pretty sure you can't write a fast numeric code without the knowledge of which type you will get on input. That's why fortran still rocks and we do nat have anything beyond fortran, c and c++ in the field of computation.
> convert?

I'd wonder about that. But, all the IP is on just a little portable, USB interface, hard drive I own, so I bring a copy with me when the C-corp is formed? Shhh, don't tell anyone!

For two steps, easy: For a solo founder and 100% owner, an LLC is a total sweetheart and a C-corp. with a BoD is a forever continuing total pain in the back side. So, very much do not want a C-corp until need it for equity funding where the founder is no longer 100% owner, and such equity funding is chancy. Equity funding is not easy to get.

I'm not counting on equity funding and, really, have given up on it -- by the time VCs will write me a check, I will long since have not been willing to accept it. My startup is deliberately designed to get to plenty of money for growth with just my labor and my thin checkbook. And, I'd greatly prefer to remain 100% owner of an LLC.
Why do we accept the out of control increase in cost to get a degree? Why is it possible to get a loan for a degree that will be highly unlikely to lead to a career that will pay off the loan?

The schools seem to have way too much power here. If this was any other industry, there would be more oversight and regulation.

The easy money from lending immunizes the schools from being cost conscious because it shifts the burden to the students, who are told they'll go to heaven if they only get a college degree.
Upvoted because of the use of AWS Lambda instead of a cron job, I believe Bitstamp offer such a feature as there is clearly demand for DCA :)

Coinbase already has, but with 1.5% fee!!

How do you make sure the transaction happens? What if my order doesn't get executed, and then 5 of them executed next week then it's not DCA anymore.
> their desktop client is based on a dead technology (and limited to a single machine without SMS support)

They're working on an Electron version (Chrome apps aren't dead yet, so they still have some time), and I'm using Signal Desktop on two machines.
I don't really see what's absurd or outrageous about the claims in this piece.
I did some research on this a few months ago and landed on this book, which is highly recommended by physicians with interest in the relationship between gut health and autoimmune diseases.

https://www.goodreads.com/book/show/15802745-the-immune-syst...
The thing that made climate change controversial is the interests (and deep pockets) of the fossil energy lobby. Science communication can be improved, but you can't reasonably blame it for this.
> If this would actually happen it would mostly just expose a tremendous shitheap of "enterprise" code created by consulting firms whose entire business model is based on delivering and "maintaining" overengineered crap with huge maintenance costs.

They deliver the same code over and over again to different gov agencies, charge them and leach from tax payers money each and every freaking time. The problem is that politicians know this (heck they even approve it), one would need to eliminate corruption to get it solved unfortunately that's easier said than done.
Behind the scenes.Short story why this News app building platform got on Android
Nope, the trackpoint is simply inferior, especially for scrolling.
in more civilized parts of the world:

cc companies (and country acquirers) have a thick book of rules and complex/expensive certifications.

if you don't follow the rules either the device doesn't get to connect or any loss due to fraud is applied on the site owner.

also: emv + single unit sealed/tamper resistant payment component (the reader, screen and pinpad are one)

also: pumps are remotely monitored for case opening and video surveillance (at the very least to counter staff theft).

this isn't a problem in some countries.
I'm sorry to say that but... have you actually tried GNU Ring? It is the least usable IM-thingy I've ever tried.

I tried it in 3 different plaforms (OSX, Android, Linux) and in every case I found (different) experience-breaking bugs (>30min to find a contact, registration timeouts, missing GUI buttons, and so on). Also, you can have multiple devices connected but not all messages will reach all devices, and of course an offline device will not receive messages sent since it was last online.

I really wanted to like it and push for it, but I just can't in its state :(
Are any of those less susceptible to any of the flaws mentioned here than Bitcoin is?
You're right[0] but it looks like it depends on age group[1,2].

[0] https://kek.gg/i/6vgYNF.png

[1] https://kek.gg/i/7-w6PD.png

[2] https://kek.gg/i/3Jn4G6.png
> all prices of everything need to adjust because the 'stupid currency' is fixed.

Thats a price system like at the gas station, right?
Sounds good to me.
Is ‘Revolutionary’ Law Firm Atrium a Case of Clearspire Déjà Vu?