skysight-inc/HackerNews huggingface dataset:
N-terminal sequencing service
Almost all of the protein synthesis starts at the N-terminus, and the N-terminal sequence of proteins has a great influence on the biological function of the protein as a whole. For example, N-terminal sequence affects the half-life of proteins, meanwhile, it is associated with protein subcellular organelles. These are closely related to the function and stability of proteins. N-terminal sequencing of proteins is helpful to analyze the high-level structure of proteins and reveal the biological functions of proteins.

At present, the N-terminal sequencing of proteins is mainly classified into two major categories: non-mass spectrometry and mass spectrometry. Traditional non-mass spectrometry includes classical Edman degradation method that takes advantage of transcription-RT-PCR to get cDNA of corresponding protein, and then protein sequence will be obtained by reverse counting. Mass spectrometry is an important method for the accurate mass determination and characterization of proteins, and a variety of methods and instrumentations have been developed for its many uses. Its applications include the identification of proteins and their post-translational modifications, the elucidation of protein complexes, their subunits and functional interactions, as well as the global measurement of proteins in proteomics. Each of which has its own strengths and constraints.

All the above is about the details of protein sequencing which can be applied for protein identification, also will be helpful for studying the biological function of the peptide/protein.
So do most contractors.
Given how much Kaspersky has done for the security and research community (the article lists several of their research projects and disclosures), it comes off as a bit paranoid not to trust their software on the basis that it's made in Russia. As far as I'm concerned, Kaspersky Lab has proven, time and time again, to be an agent for good, not ill. The Snowden leaks showed direct US government involvement with several tech giants, and yet we haven't blacklisted use of their products yet. Arguably, we "trust them more," but I think that trust is misplaced. Kaspersky, on the other hand, has earned a lot of trust by actively participating and engaging with the security community regularly.
Yes. These people are so far removed from the actual products they create that you get this type of drivel. I can't imagine how much time was wasted with all this.
1) It will be very soon: http://www.cs.princeton.edu/~appel/certicoq/
CertiCoq is a formally verified compiler from Coq to assembly (using Compcerts backends), not just an extraction to Ocaml/Haskell/Scala.

2) Extraction is not the only approach to verifying software with Coq (see Verifiable C, or Bedrock). In other proof assistants, e.g., in Isabelle or HOL extraction isn't even available and so other approaches are common. For a nice example look at the bootstrapping process of CakeML (https://cakeml.org/).

3) Even if it wasn't, the point is that the trusted base with verified software is tiny compared to anything else that people are actually using. "It's not perfect" is not an excuse if it is basically perfect in practice. See the Csmith paper ("Finding and Understanding Bugs in C Compilers", https://embed.cs.utah.edu/csmith/) and what they had to say about CompCert.
It'd be nice to use NFC to temporarily activate Bluetooth for a given device, for the duration of use. Even better if it generated a random MAC address every time you established the connection, and handle auth entirely in userspace through encrypted channels. You could bypass the stupid Bluetooth auth.
This is a condescending attitude. People vote against their interest all the time. The HN crowd is generally in the top 10% of income and they vote for Democrats who will raise their taxes.
NOAA Hurricane Hunter Flight into Irma
You grew up and realized it barely matters.
Ah, the "report circulating in the Kremlin today". Has to be true.
From the BBC recently an article about a CEO who dyed her hair and wore glasses to increase odds with VC.

"I dye my hair brown to be taken more seriously at work"
http://www.bbc.com/news/magazine-41082939
I note that your mailto: links don't include an email address.
e.g. at the bottom of the page https://www.forthepeople.com/class-action-lawyers/clergy-sex... the mailto link (black envelope image) has the email address "?".
This reads and looks like it was written by a teenager. Quite ironic that it is preaching professionalism.

Edit: I did not mean this as "only girls are unprofessional" so I removed that part. Teenage boys are equally as unprofessional, but I don't think they express it in the exact same way. If this was filled with dick jokes and the like I would have written "teenage boy".
I see $3-4b in R+D per year
As a happy customer, I came for the custom sieve script many many years ago, and I've stayed for many other reasons.

Thank you.
I've heard the former but I have never heard the latter unless it's been one of my friends in PE trying to justify it.

It's the investor's job to make sure their investments are producing an adequate risk-adjusted return, not the government's job to help you get there.
Solid article, there is a middle ground that is missing, that or a base plus bonus of the team. Some of the best sales teams I've ever know work based off a bonus for the whole company meaning they have a huge incentive to help the other members of the team get better and collaborate for the betterment of the company.

This will create the best sales team, but will not attract the top X% of sales people.
I wonder how it affects people from China and other non-alphabet-using countries.
I deleted the FB app when I had a nexus 5 as it was a major battery drain. I barely go on facebook these days.

What every tricks they are playing, it has reached saturation in my mind.

I just don't find it that interesting or providing any value at this point in time.
Hackers could program sex robots to kill
What's the value of a credit card number? It can quickly be changed and you would be hard pressed to exploit a billion of them at the same time.

What's the value of a psychological profile built from FB data? People say Trump won the election because Cambridge Analytica built a psychological profile of most Americans and targeted them with customized propaganda. Probably an exaggeration, but it's early days. This will only get better. Can you make your psychological profile invalid the same way you can change your credit card number?
Yes, it matters who does the job. Good teachers have measurably better effects on students than bad ones. Here's one essay with a lot of statistics: http://www.nytimes.com/2012/01/12/opinion/kristof-the-value-... . I also remember hearing a few years ago that a good teacher can teach about twice as much in a year as an average teacher, but I'm not sure if that's the same as the 40% number from this article or something else.

The effect is an especially big deal in math, because it is so cumulative. One of the worst things that can happen to a student is to have a bad math experience (whether it's the teacher, the other kids in the class, or whatever) one year, and then have future teachers never go back and cover the same material. That leaves students with permanent gaps in their knowledge, which hurts them later on.
Tesla was conceived, according to Musk, to kickstart the industry.

https://www.tesla.com/blog/all-our-patent-are-belong-you

And that's what it's done. Interesting that in three years, the landscape has changed a lot.

> At Tesla, however, we felt compelled to create patents out of concern that the big car companies would copy our technology and then use their massive manufacturing, sales and marketing power to overwhelm Tesla. We couldn’t have been more wrong. The unfortunate reality is the opposite: electric car programs (or programs for any vehicle that doesn’t burn hydrocarbons) at the major manufacturers are small to non-existent, constituting an average of far less than 1% of their total vehicle sales. (2014)
>I've written a few times about how the different tax rates on income, vs dividends vs interest income vs capital gains, and even business vs personal tax rates all work together to ensure the 1% come out ahead of the average income earning individual.

I don't think that's right. If you look at the dividends in isolation, it looks like a low tax rate. But if you ask "what's the tax rate on capital income?", then you have to adjust for the fact that, before the capital can pay out anything, the investment must pay taxes on profits (35%), taxes on dividends (15%), and taxes on undistributed gains when selling (capital gains, 15-35%).

So, trace out the taxes on a $100 investment that miraculously pays for itself and throws off $200 in profits on top and pays $50 as a dividend. I exit the position. How much was I taxed at?

$200 profits -> $70 in corporate income tax. (35%)

$50 dividend -> $7.5 dividend tax. (15%)

$115 capital gain (it retained $115 of the $200 profits, raising its market price by that much) -> $17.25 capital gains tax (15%)

Total investment (capital) income: $200.

Total capital income tax: $94.75 (17.25 + 7.5 + 70)

Total capital income tax rate: 47.3% (94.75/200).

(That understates it since you can't deduct inflation.)

And keep in mind, investment is believed to have positive externalities!
Monkey selfie copyright case settled
Depends on the newness of the attack. It can take awhile for an attack to get into the CVE DB. Though usually it says "this CVE is reserved" rather than "not found."
I don't really care how they're computed, right? All I want is someone to tell me where to eat and be good at it.

It could be based on my preferences, and how I've rated things before, it could be based on social data, it could be based on a conversation with a chatbot. It could be a combination of all of the above.

The way the information is derived is really unimportant, the important thing is that I am happy with where you tell me to go.
Do you trust yourself? You can choose whatever compiler(s) you want as the 'trusted' one(s), even writing your own. It doesn't even need to be a very good or complete compiler.
https://breakingmalware.com/documentation/windows-pssetloadi...

For the full technical details.
I'd like a screen reader that read the graph like "One hundred twenty three. Boop. Boop. Boop. Boop. Boop. Four hundred twenty four." with the pitch of the "Boop" proportional to the value.

Sounds like a job for aQuery! ;)

http://donhopkins.com/mediawiki/index.php/AQuery
Is Google Down? Google Apps Accessibility Issues
Seriously, your post would have read a lot better if you'd trimmed it to the Upton Sinclair quote...

> Except this isn't about who invented the false premises modern economic thought is based upon, it's about who perpetuates them and why.

Right wing academics at predominantly state-funded academic institutions have obviously promoted a particular economic worldview for the past century and a half because they want to be made redundant, not because they believe in them? I'm not convinced everybody who doesn't agree with your views on the economy is only in it for the money, especially the most influential economists on the right who became recognised and even died long before the Kochs started spraying money around.

> I wasn't even aware the Koch brothers were pro-gold standard.

That says a lot about how effective they are at influencing economics...
The Kochs fund the Mercatus Center, pretty much the only academic economics department that takes gold standards seriously. Their much-favoured CATO institute was founded by Murray Rothbard.

> The front page on their website right now is an article downplaying inequality. Karl Marx would be so proud.

The front page on their website carries articles about elite financial networks running the world, disappearing middle classes and where modern macroeconomics went wrong (and yes, an argument for spending tax dollars on poverty alleviation rather than just looking at inequality stats). Obviously this is all part of the conspiracy to promote mainstream economics and the interests of the rich. And Stiglitz and Volcker both taking funding from the same source is a clear sign that economic thinking is entirely dictated by where the money comes from.

As for Marx, it's lucky that literally no economist has ever written anything complimentary about him, although I suppose if they did it must have been for Russian funding.

> Note that one of the most cited & praised economists in this thread (keen) for his (actually) heterodox approach was actually made redundant from his university not that long ago.

Keen's version of events is that the university shut down the faculty because his neoclassical colleagues weren't popular enough and he took voluntary redundancy rather than be a professor on a business course...

> Obviously. It's a simple jump from state university professor to a trader raking in $1 mil bonuses.

Obviously state university economics departments are full of professors who would sacrifice their beliefs for fast career progression and high salaries who just couldn't find anyone else that would hire an economics grad.
I had read this as Bots slamming into buildings, and was looking for a discussion of lidar and stereo vision systems.

But won't lidar have the same issue, with a clean glass surface? Similar with stereo vision - if there are no features at the surface to correlate.
I have a hard time taking this website seriously. There are a ton of anti-semitic "resources" listed. https://screenshots.firefox.com/jf2JY3rYUwAI6ZaZ/theunhivedm... https://screenshots.firefox.com/9ThjB3mgov2gKcUM/theunhivedm...

I'm not going to take a website seriously if it is denying the holocaust.
As a recipient of those emails -- not really. Clients block remote content by default and there's almost never a reason to load them, especially when they're used for tracking. Those 'pretty' emails will almost always look like a soup of image placeholders interspersed with text.
Check out these 5 startups from AngelPad’s 8th batch
FYI, LinkedIn has somewhat fine-grained email/notification configuration so you can stop these at the source.

Have a look at Me (menu) > Settings & Privacy > Communications (tab) > Email frequency (controls not only overall frequency but frequency per message type, i.e. group message notifications, invitations, job notifications, connection update notifications, etc.).

Also, you can entirely disable classes of notifications you no longer want to receive/see (even when you're viewing the site) by going to the Notifications tab, then clicking the context menu ("...") on a given notification and selecting "Turn off" (stop receiving this type of notification) or "Unfollow" (stop receiving updates from the given source).
Yes they have immense amounts of personal data and that is worrying. It is worrying they share this data with government agencies, marketing agencies etc.

BUT, unlike Equifax they haven't been completely compromised by hackers. Equifax is unique it's level of incompetence. I'm surprised the equity is holding up as well as it is. The company is grossly negligent.
The author updated the post [1] with " It details a workaround for this bug, again, not a vulnerability."

[1] https://breakingmalware.com/documentation/windows-pssetloadi...
Whoa, where do you live? I live in a cheap-as-hell nowhere mid-sized Midwestern city and $85 for a contractor's... not top of market. Closer to $125, maybe a bit higher. You might get a discount for a long-term gig, but $85'd be a steep discount. You'd pay even more for someone who has actual skills in a rarely-needed (locally) field or specialty (most of those people move to Colorado or get locked up by a handful of large local companies).

[EDIT] Nevermind, saw your post clarifying/emphasizing the W2 angle down below. That's probably about right, then.
How about not remember right-from-left hand? Not remembering if the hot water is on the right vs left? Switching syllables in longer words? <- all of these are me.
The real problem is Google is opaque in dropping such mail in recipients spam folder. Hotmail can sometimes be annoying in this regard too. As far as I've managed neither does the sane thing and add a header that report on how they've divided that "this mail is spam" - so the recipient doesn't have anything to go on either, other than hoping "mark this as bot spam/add to address book/send email/reply to address" help Google/Ms treat it as "not spam".

Maybe it's worse for non-English mail (maybe the statistical models are biased against "not English" even for people whom don't have English as a native language).

But I'm quite convinced google's (and to a lesser extent Hotmail/ms') "magic" spamfiltering is subtly (but annoyingly) broken.
You can elect to have your LLC taxed as an S-corp to avoid some of the self-employment tax [1].

1. https://www.thebalance.com/what-is-a-reasonable-salary-for-a...
Functional Client-Side ClojureScript UI Programming with Webfui
The key is to reduce the friction of getting features out on the open web and getting feedback from real users. have just one generic domain that can be repurposed to any idea. Attach it to a static ip on aws do or up cloud as an example. Use a rad framework like rails django or laravel and launch a permanent hello world by pushing to github. Now find a small group of users that have a problem you can solve. Spend an hour a night adding a page to your site and gather feedback. Rinse and repeat. The key is to have a basic ci/cd pipeline setup at the outset. Then iterating on ideas becomes much more easy.
Facebook encourages a lower level of discourse than other message systems, somehow.

I participate in a couple of groups which have come to replace older forums running PHPbb or VBulletin type software. While the old style forums offer too many features and almost excessive permanence for discussions, Facebook offers too little in that regard.

Conversations are not meant to be searchable, archived, permanent, or long or detailed. Unlike VBulletin, where it's easy to find a post you saw 3 days ago or all the posts you've made in a forum, on Facebook everything effectively disappears after a week or two. The content is still there, just very disorganized and difficult to access. Search is inconsistent and very basic for groups.

Most significant is the impact this has on the discussions that take place. On the old forums, posting seemed like a bigger deal and people rarely posted one word responses or sentence fragments. The FB format seems to encourage that. Long, detailed responses about technical matters are difficult to post and read, so people don't post them as often. Discussions are often repeated because nobody can really find the last one to link to it.
Evolution is the change in gene frequencies over time. Accepting my premise is just knowing the textbook definition.

I think what you are trying to describe is "novel fitness increasing mutations" - these won't be detectable for ages as it takes time to spread through a population.

Single isolated events matter - All mutations start off in an individual, they then increase or decrease in frequency.
I didn't know about noprocrast! Nice.
I can't find an authoritative source on the claims of the "US exploding" in response to "Kaspersky closes CIA backdoor"

* GSA already pulled it from their recommended list months ago: https://www.wired.com/story/why-the-us-government-shouldnt-b...

* Yes, a Senator was pushing for banning Kaspersky from government infrastructure: https://www.theregister.co.uk/2017/09/06/banning_kaspersky_f... - not much traction yet

* Best Buy, as of a couple days ago, was pulling Kaspersky out of fear of Russian influence: http://www.reuters.com/article/us-usa-kasperskylab-best-buy/... - so far they are alone

Now look at the rest of this website and rank their trustworthiness from 1 to 10. Check out those drop-down menus at the top, the sidebar content, their other posts... how trustworthy is this site?

This seems like click-bait lies at best. Shouldn't have made it to HN in the first place.
copying verbatim relevant sections

" the estimation error quickly increases with the population size due to the underlying truthful distribution distortion. For example, say we are interested in how many vehicles are at a popular stretch of the highway. Say we configure flip1 = 0.85 and flip2 = 0.3. We query 10,000 vehicles asking for their current location and only 100 vehicles are at the particular area we are interested in (i.e., 1% of the population truthfully responds “Yes"). The standard deviation due to the privacy noise will be 21 which is slightly tolerable. However, a query over one million vehicles (now only 0.01% of the population truthfully responds “Yes") will incur a standard deviation of 212. The estimate of the ground truth (100) will incur a large absolute error when the aggregated privatized responses are two or even three standard deviations (i.e., 95% or 99% of the time) away from the expected value, as the mechanism subtracts only the expected value of the noise."

"In this paper, our goal is to achieve the notion of scalable privacy. That is, as the population increases the privacy should strengthen. Additionally, the absolute error should remain at worst constant. For example, suppose we are interested in understanding a link between eating red meat and heart disease. We start by querying a small population of say 100 and ask “Do you eat red meat and have heart disease?". Suppose 85 truthfully respond “Yes". If we know that someone participated in this particular study, we can reasonably infer they eat red meat and have heart disease regardless the answer. Thus, it is difficult to maintain privacy when the majority of the population truthfully responds “Yes".

Querying a larger and diverse population would protect the data owners that eat red meat and have heart disease. Let’s say we query a population of 100,000 and it turns out that 99.9% of the population is vegetarian. In this case, the vegetarians blend with and provide privacy protection of the red meat eaters. However, we must be careful when performing estimation of a minority population to ensure the sampling error does not destroy the underlying estimate."
Corporations have both positives and negatives, yet somehow there's never a debate over whether we should have those.

It's very strange to me that employees organizing and working together is so controversial, but management doing the same thing is not only expected but we can't even envision anything else.
The Obama tax hikes were largely aimed at high capital incomes,
though the accompanying high pay tax hikes was hardly "screwing the voters" either.

See http://money.cnn.com/2015/01/30/pf/taxes/obama-taxes-rich/in...
So what's the end game for Tesla ? owning the best charging network with large network effects, and getting high margins?
"primary focus of an automotive manufacturer is their powertrain"

The VW Group re-uses the same engines across lots of its different brands - for a high-performance or electric car then of course the powertrain is important. For everything else its just one component and as long as it is good enough I suspect people aren't really that interested.

Edit: Other manufacturers may do this, I'm just more familiar with VW Group cars.
This is a Sorcha Faal article.
Sorcha is a well known hoaxer.
http://rationalwiki.org/wiki/Sorcha_Faal . Even on conspiracy forums, when the author of some report is found out to be Sorcha Faal the thread usually ends as that guy has been hoaxing conspiracy theorists with plausible sounding made up articles for at least a decade if not longer.
Surely this? https://twitter.com/1990sLinuxUser/status/669488129150177280
That seems questionable. In a lot of school systems, the best teacher may be the difference between a kid ending up in jail or not, but kids that are flirting with that line aren't going to be particularly successful on aggregate. And American society loves sending black kids to jail. So, what's the value add there?

It's so much more complex than that.
One of our bigger apps is showing about 1%.
Overriding Equals and Hash Code in Java