skysight-inc/HackerNews huggingface dataset:
David Liu's lab last week published [1] an updated version 4 of their genomic "Base Editor" that is capable of switching a C to a T with sequence specificity within a living genome. I try to break down the sequence and componentry of the genetic machine that provides the edits.

I'm trying to help demystify the mechanical nanotechnology being used in genetic engineering. In some senses they're quite simple, 5 or 6 component machines. This is one of the more 'advanced' proteins I've seen built, and it only contains 8 different kinds of components.

[1] http://advances.sciencemag.org/cgi/content/full/3/8/eaao4774...
Amazon does the same thing, once they lock up your account there is nothing much you can do except make a lot of noise and hope you'll be heard.

I had a horrible experience with a buyer account, they locked it up, and I didn't even receive a notification about it (I thought it was hacked...). The problem is that I had some packages on their way and I could not access any tracking info, etc.

After a couple of distressing days, access got restored with no explanation as to why it was locked in the first place, and I still have to hear from them what happened.
Absolutely no one cares to suppress palatable, well meaning, everyone agrees to it speech.

One of the demonstrators from the Bret Weinstein debacle at Evergreen can be seen and heard on the Vice video saying, "...F### your Free Speech!" That is pretty much what the demonstrators and those aligned with them did to Bret Weinstein -- all just for saying, Maybe there's a problem when you demand that certain ethnic groups "absent" themselves? Why would anyone who stands against racism ask that of a Jewish man?

https://www.youtube.com/watch?v=9ys2ihv_wSs

https://www.youtube.com/watch?v=2cMYfxOFBBM

https://www.youtube.com/watch?v=-fEAPcgxnyY&t=327
I truly appreciate the feedback :)
Cassini's Last Photos Will Be Spectacular
The main two reasons for divorce are infidelity and money issues.
Hi guys, I asked this question on Twitter as well. Is there a way to model proof of work vs proof of stake using something like Jepsen/Merkleeyes.

I'm looking forward to see some Jepsen style testing of the different blockchain protocols, but doesn't seem to be anything out there that can model these aspects.

In building Tendermint, did you figure how to test and validate these aspects of blockchains ?
I think it's a near perfect solution to the problem of recording and transferring ownership of deeds and titles.
Registering a business should not be a problem.

In terms of opening a bank account, SEB now offers a way to do that through a video meeting: http://www.seb.ee/eng/remote-advisory, although right now if you're not yet a client, you can not use it. They promise to open it up for new clients as well, but no ETA I think.
But I'm not, so I'm not allowed to. I wouldn't have a problem with it if I could - paying for ad-free YouTube with added features seems like a fair deal to me.
As a Puerto Rican preparing for Irma, yes, we're pretty freaked.
Correlation is not causation but it's rarely accidental.
So we should sacrifice all the things that actually make a Data Scientist's work valuable in the name of fun and obscuring mistakes?

Fun I almost get, obviously good for productivity (though I think you'd really be sacrificing productive output for non-productive output), but I just don't get where you're even coming from with the "making mistakes more obvious" angle.
I've got a Christmas vacation booked in Providenciales and I give it a 50/50 chance the VRBO I booked will still be there.

People are trying to get off Grand Turk as fast as they can.
The airlines have overbooked outbound flights and the airport is closing on Thursday for 48 hours. I'm hoping the damage is minimal. outoftacos mentions that eastern sides of the islands take more of a hit which gives some solace here.
Yup, if Make was used extensively for Javascript, I wouldn't have had to file this feature request:

https://github.com/webpack/webpack-cli/issues/152
I love the soundtrack. Many lines of code were written to it

https://www.youtube.com/watch?v=RRI-o9JDfCI
Are ICOs binding?

Can you claim failure after a best attempt at building the proposed product?

Can you build a shitty version of the product via outsourcing via Upwork to a third world country. And then claim surprise when it barely functions at all?
Infidelity is definitely higher, maybe they are better at keeping secrets?
It shouldn’t be too hard: [kilo](https://github.com/antirez/kilo), the editor on which this is partially based, is modeless. All of the modes are thus addons that I’ve built. You’d have to tweak a bit of the code to make it usable as a modeless editor, but it could definitely work!
User Auth with Ionic and AWS
I know. We all did.
As a dev, comparing technologies given that I've already used Vue and React, I still see lots of code that I've become accustomed to not needing to specify, making even Polymer 2 still feel clunky and bloated: there is still no reason for that "is()" or "observedAttributes()" (tooling should take care of that), and the fact that you manually need to initiate the super chain in connectedCallback instead of having a side call to a function with a name that indicates what it's actually for, with the chain taken care of by the super class (if your callback function has the word "callback" in it, that's already a wasted 8 characters that could have been used to actually name the function after what it does) still makes me go "this is silly, why would I go back to such a verbose technology?".

Polymer 2 looks better than polymer 1 for sure, but if I'm comparing what I need to write in React vs. Polymer 2, the former still beats out the latter in terms of low effort, high productivity.

And to be clear: the reason I think (and the numbers bear out that) React and Vue etc. beat out Polymer still is because they can do the same things as polymer: the on-page result is identical. Except React and Vue offer a better dev experience... provided you buy into the development model, of course. But this is also true for people who first start with Polymer: they have to buy into the idea that the classic web stack is the best solution to the problem of needing custom components.

And that reveals the major difference, in turn revealing another reason why Polymer is not as popular as one might hope: Polymer is a web presentation and interaction technology, whereas for instance React is a universal UI technology. They're not even remotely the same thing: the latter is effectively a superclass of the former. For example, as long as you call the functions that React tells you need to be used to effect UI updates, you will never have to think about "where this code runs". Web? Mobile? Desktop? Someone's GTK+ application on embedded hardware with JS support? It literally doesn't matter: call the functions, and it will work. The fact that the DOM is used in the browser is pretty much irrelevant to React - it's only relevant to devs who want to explicitly tie their UI to APIs that are only available in a browser. Polymer takes an approach that is diametrically opposite to this: it keeps things as "webby" as possible, making you write DOM, and only DOM, elements.

So that is another reason for the difference in dev experience: React has abstracted as much as possible so as to only expose what you need because it wouldn't be able to do its job as UI technology if it kept exposing platform-specific construct, whereas Polymer can keep things explicitly tied to the browser stack, and thus never got pushed to be as self-contained as possible, with as high a productivity:effort ratio.

(and whether that's a good or bad decision is irrelevant when discussing 'why is one of these more/less popular than the other', even if I certainly have opinions there. I'd love for React to be more webby, like polymer, but if it was, it would be much clunkier)
By this logic Elizabeth Taylor would have been a great marriage councilor and anyone with a great marriage should STFU about it.
I really hope they updated the audio stack to make latency lower. Right now doing anything sub 10ms with audio is impossible.
Why is it so difficult for a forum to accommodate different political views? Is this a problem of human nature?

The idea of a uncensored reddit it a good one, but the first thing I see going to the page is an administrator complaining that they apparently cannot effectively ban "nazis".

https://raddit.me/f/lobby/6159/we-re-being-brigaded-by-nazis...

From the comments I've read here, it definitely seems as though the site has the typical heavy handed administration banning opinions it disagrees with.

Why can't any of these sites just allow people of all political ideologies to post? 4Chan is the only site I can think of which has never had censorship of this sort. Why is this such a difficult thing to accomplish?
Lenovo Wasn't Paying Attention: 750,000 Laptops Had Spyware
WinBtrfs – A Windows driver for the next-generation Linux filesystem Btrfs
Lenovo settles FTC charges that Superfish software compromised security
I tend to agree: it is largely true in the US. Not so in the rest of the world (outside of the Western world), and not necessarily so in certain parts (more precisely, social strata) in the US either, such as the ghetto.
Twitpic got bullied, it didn't lose in a court of law.
Huddle sold to PE firm Turn/River for est $89M
I feel like agreeing with your sentiment, though your example seems a bit off. Becoming cardiologist is like a decade of school and certifications, so in my opinion, the better analogy would be criticizing a movie without writing/directing a Hollywood-scale production.
Lilium, a Flying Car Start-Up, Raises $90M
So maybe audio engineers have the lowest divorce rates because they make good money and are quite concerned about fidelity? (This is my bad pun for the day).
This is unclear. Do you work for Youtube or Android?

E: This is a simple and earnest question. Why the downvotes?
Absolutism has the virtue of simplicity, to be sure. The human world, in my experience, has not.

The judicial system is pragmatically absolutist in its operation. It's quite complicated, it's not perfect, but it does work. The system of rights it's constructed on is necessary to prevent tyranny. Look up and read the history around the Magna Carta and the founding of the United States.
Bioengineers develop robotic device to help disabled kids
> So how long is long enough? one contribution? ten? Serious question.

The formal name of this is Proof Of Work (PoC). The idea is to make "mining" blocks take non-trivial amount of computational work in order to forge another transaction block. When a miner finds a valid nonce, it announces it to the rest of the network so others can begin working on that chain.

When I say non-trivial amount of work, it would take my computer (nVidia 1080 @ 20MH/s) ~3.5 years to mine one Ethereum block as of now. Comparatively, the combined power in the Ethereum network (119.4 TH/s) mines blocks every 24 seconds.

Additionally, the miner that finds the correct nonce that makes a valid block is rewarded. This incentivizes each miner to keep up to date with the latest blockchain and abandon lagging branches and work.

> How does one know with certainty that work was accepted by group consensus?

Through these rewards and the large computational work involved in mining new blocks, the majority of the miners aggressively gravitate to the longest chain. That means that the longer chain continues to grow longer much faster than the other branches. It's this aggressive growth combined with the reward incentives on the longest chain that keeps the whole network honest. Why mine a block that the network won't reward you for? For the individual miner, it's in their best interests to always be working on the longest chain.

> This uncertainty seems to undermine the idea that blockchain is a trustworthy, predictable, verifiable ledger of activity if the work contributed cannot be known as reliably preserved at the time it is submitted, only later in review.

This is part of the security of the blockchain. This prevents malicious agents from pushing "valid" blocks, even if they manage to get all the dots in a row. The computational work involved in building the next block is vastly outpaced by the general network; by the time you minted you "attack" block, many many many new blocks were already minted by the network and they won't accept your block. This "consensus" keeps these attacks from happening.

However, this still can be attacked. If an agent gained control of the majority of the network computational power, then they can mine blocks faster than the honest miners, thus growing the longest chain and thus control exactly what transactions/blocks are mined. This is referred to as the 51% attack because they become the Consensus.

But, using my calculations above, I would need somewhere around ~6*10^6 nVidia 1080 cards all working for me to gain majority in the Ethereum network. So I sleep comfortably at night knowing my ETH is safe.
I think the biggest question here is what saves more dirty energy. Obviously, these units will compete with solar for roof space. The sun beats down in the summer, where these panels would be most useful, but also where solar would hit peak power generation. As long as solar can supply at least 20% of the power required to cool the building, it seems like it will be a better option, as solar is also useful for other things like charging electric cars during the winter, when A/C is not required.
It says right in the article that there is a new low latency audio API.
All of your prep/efforts could be worthwhile, you just haven't found your opportunity yet. The path to wherever you want to go might not be linear.
I would love to see Police officers and Firefighters... anecdotally, I would expect a very high divorce rate.
There's another graph that shows that divorce rate and average occupational income are linearly correlated, with higher income yielding lower divorce rates. This is all pretty well known, AFAIK.
I learned the hard way that my own health comes first even to my kids. I had a kidney stone episode that really put me out of my mind. The pain was so bad I could not think on anything but to survive. I couldn't even remember I had a family in the first place. So my health comes first, if it deteriorates, all the external world goes away.
Stay safe and I hope all goes well with minimal damage.
You don't really need to know all of these. But the list is great.
I made my own Kilo and have wanted to eventually build it into something like this (Vim-ish and Lua extensible.) Eventually, I will find the time.

Good stuff!
a hard steer to the right would be nice... but many of them do a slow steer and would get me right in it... http://www.stuartflelectrician.com/wp-content/uploads/2015/1...
Had Taylor found herself in a good stable marriage after her poor one your comparison would match the authors. But I guess it doesnt and you're being flippant.
Tendermint doesn't use Proof of Work (PoW). PoW is hard to test with Jepsen because it only supports probabilistic safety, which means the chain can constantly reorganize. If I'm not mistaken, Jepsen would consider PoW's routine reorgs as linearizeability failures. That said, Jepsen could potentially be modified to support this better, for instance only considering something accepted if its buried X blocks deep.

Tendermint, in contrast, provides deterministic safety, and serves as a building block for Proof of Stake networks.
Quoting from the OP:

Many economists say there is no need to worry. They point to how past major transformations in work tasks and labor markets – specifically the Industrial Revolution during the 18th and 19th centuries – did not lead to major social upheaval or widespread suffering. These economists say that when technology destroys jobs, people find other jobs. ...

As one economist argued: "Since the dawn of the industrial age, a recurrent fear has been that technological change will spawn mass unemployment. Neoclassical economists predicted that this would not happen, because people would find other jobs, albeit possibly after a long period of painful adjustment. By and large, that prediction has proven to be correct." ...

These economists are definitely right about the long period of painful adjustment! The aftermath of the Industrial Revolution involved two major Communist revolutions, whose death toll approaches 100 million. The stabilizing influence of the modern social welfare state emerged only after World War II, nearly 200 years on from the 18th-century beginnings of the Industrial Revolution. ...

Today, as globalization and automation dramatically boost corporate productivity, many workers have seen their wages stagnate. The increasing power of automation and artificial intelligence technology means more pain may follow. Are these economists minimizing the historical record when projecting the future, essentially telling us not to worry because in a century or two things will get better?

The author's answer is, WE SHOULD WORRY, because the adjustment already is and in the near term will continue to be painful. It's hard to disagree with him.

This article brings to mind John Maynard Keynes's most famous quote: "Economists set themselves too easy, too useless a task, if in tempestuous seasons they can only tell us, that when the storm is long past, the ocean is flat again."[1]

[1] https://en.wikiquote.org/wiki/John_Maynard_Keynes
Why didn't you just choose to not have a heart attack? That is half of the writer's thesis.
> Because your employees are human beings and not machines. They have a life, they have needs, etc.

...they also have access to gmail and a thousand other services, no?

> People have rights, even while working for an employer. They are employees, they are not slaves.

being asked to use gmail (etc) instead of company systems for your personal stuff doesn't 'make you a slave'.
The link above has a graph showing the industries by medium income. There's a pretty clear correlation, with some outlier professions.
Can someone explain to me what the x-axis means in the "Divorce Rate By Occupation" chart? It seems to be just a random distribution from -1 to 1, because the author wanted to use dots to represent each title. I suppose that's a very space-efficient way of representing the data, but it's also pretty tedious to have to mouse over everything, and it doesn't work well on a small screen.

Might have been better just to put this in a list.
I used to think that but it turns out that arranged marriages are quite successful: http://www.statisticbrain.com/arranged-marriage-statistics/

Obvious it's not as simple as comparing the divorce rate of love vs arranged marriages, cultural factors play a huge part but from what I've seen in India the fact that they're committed to making it work seems to make for happy couples.
The title is mis-leading and click-baity, but the article argues a more reasonable position. A more appropriately named title would be "Before giving advice on how to climb out of poverty, think a little harder about all of the consequences of a given decision before recommending it to the poor, especially if you haven't had experience living in poverty."

She uses the example of "getting rid of your car", which sounds great until you tally up the costs of increased child care, reduced hours, and limited comparison shopping.
Also, I recommend that any concerned intellectual read this book:

http://a.co/bAOViyI

(Warning, the cover has a picture of the Hitler salute, but it's squarely anti-Fascist.)

It details the ideological underpinnings of the above. They say explicitly that they want to replace the current social order. The erosion of human rights is one of the explicit ideological goals of the leadership of both the far extreme right and the far extreme left.
No it's more than that; perhaps you haven't discussed with some people, but a great many people actually do believe fish are not animals. It's not mere semantics, they don't actually consider them animals at all, as if animal, plant, and fish are all different categories. Don't dismiss as pedantry what is actually a very interesting topic.
Most military positions aren't overseas or combat-related. I'd imagine it would be higher for those ones though.
I have an email address that's on the old Mt.Gox leaked database.

I get spam every day now advertising this or that new ICO. And I check up on them and every time they're making millions.

New way to earn cash from spam I guess...
Magic Leap appears to be so focused on "cinematic reality" and the impressive demos that it enables that there is no effort being spent on the kind of practical applications that would actually give a shipping product value beyond a tech demo.

Worse, even ML's occasional stabs at something "practical" are all art and no design: Witness their conceptual Gmail interface, which transforms the web UI into a Rube Goldberg-esque mechanical device, giving scroll views a third dimension that adds zero utility while requiring new gestures to do the exact same things everyone already knows how to do in a web browser.

Microsoft may still have yet to deliver on any of the content creation and collaboration ideas proposed in the Hololens demos, but at least it was the start of a coherent vision.
Show HN: Boostnote Mobile – Markdown notepad for programmers
I think if you don't put forward a bona fide best effort, you are vulnerable to fraud charges. Yes, you can probably build a shitty version. But if it can be proved via any email or conversation or some other means that this was your intent, you will be vulnerable to fraud charges. You can't just steal the money you raised in an ICO
If exchanges followed KYC, which they eventually will, then this would also not work. If you had to prove you are an American to use the USD -> x-coin pipeline, then good luck turning your Francs into x-coin.

But maybe Zimbabwean exchanges don't follow KYC. That's great for you, but going Franc -> ZD -> x-coin exposes you to a lot of other problems.
Military does cut spouses checks, so there is direct financial incentive to remain married (at least on paper).

Long deployments / remote spousing also leave room for other arrangements. As long as the checks come in, why not remain married in name only?
Rust 2017 Survey Results
I really like the amount of info spaghettimodels.com gathers into one place.
Yeah, but I have a feeling that we're both outside of the set of people who would make the statement I was quoting in my OC, which might explain why you and I can't find such a rule.
>> The game is now what it could have been

Do you mean that like "it's got as far as they can reasonably take it, it could never have been more than that" or "it has fulfilled everything that it was ever supposed to be"?

Because the former is a little tautological but likely correct, and I'd be surprised if it's really the latter.
Well sure, no touch is much safer, but the introduction of the trapezoid still made things much more dangerous. Icing worked the same way before and after (until a couple years ago) 2005. You didn't have defensemen getting drilled as often before 2005. No touch icing was introduced because the rule changes in 2005 made the game faster and more dangerous.
Romania and Poland were never soviets. Communist, yes. Behind the Iron Curtain, yes. Members of the Warsaw Pact, yes (Poland is kind of obvious on this). But never soviets.
Don't Confuse/Conflate Database Consistency with Truth
She claims her rent was half her income, but dismisses the suggestion she should have gotten a roommate. When I was poor and in college, I shared a one-bedroom apartment with 2 other students to cut expenses. We took turns sleeping on the couch. I also worked in restaurants where your compensation usually includes a free meal. But, I feel sympathy for the author. Those years, and the years just after that were tough financially. I can say that your later years will be much better financially.

https://smartasset.com/retirement/the-average-salary-by-age