skysight-inc/HackerNews huggingface dataset:
> "It doesn't appear (to me) that selective lethality would account for this data."

Please go into more detail about what selective lethality is not explaining. Under that explanation

1) They started with ~35 wild type and ~35 mutant.

2) The treatment killed about half the mutants (but no/few wt) via inducing toxic double stranded breaks.

3) They end up with the original ~35 wt plus ~16 mutants, thus increasing the proportion of wt.

Regarding heterozygosity:

4) In some of the surviving mutants the cas9 damaged the DNA during the 2-cell phase or later, thus knocking out the mutant allele in some cells but not others.

As I said, I do not see what is difficult to understand. It seems to me guaranteed that a process like this accounts for at least some of the "editing" (ie, it is impossible to not be happening at all). Really, it is only a matter of what percent of the results are due to this.
Honestly, I think the future is going to be iOS and Android for consumption of media and basic tasks, consoles for gaming, and Linux for development.

Apple and MS both ruining the desktop.
Is Trump the most eloquent politician.

Is bieber a musical genius ala Bach.

Is mcdonalds fine dining.

Not a single field that ever was has amicable correlation in regards to position to talent or knowledge. Yet the ones mentioned own their fields.

Likewise it hasn't totally fucked up society either.

We will deal with it and compensate where we can. This might even be human nature or the natural evolution off things.

As a coder one must see that it's statistically highly unlikely that after millennia of society turning out this way, now is going to be the nexus point in time where we find our figurative salvation.

If one cannot take this into account, one should perhaps evaluate their own critical thinking skills.
Yup. I imagine that running Proforged caused him to want to simplify EDI.
> And vertical farming, hydroponics is cool tech and RGB LED's are cool to increase size, weight etc for increased profits. None of that has a positive influence on sustainability.

Did you even bother to read the article? That has massive implications on the amount of water, energy and chemicals used.
Yes, the most important operation: string validation!

UTF-16's validation concerns are:

1. Broken surrogate pairs, which is mostly benign.

2. Byte-order confusion.

While UTF-8 has:

1. Invalid code points, for example, code points for surrogate halves.

2. Invalid code units, such as 0xFF.

3. Non-shortest forms, where a character may be encoded multiple ways.

4. Representation of NUL, and potential for confusion with APIs that expect null-terminated strings.

In practice the UTF-8 issues have caused much more serious vulnerabilities.
So Zello is a battery flattener? Perhaps a few Signal groups with a bot would have been better, as the other cited issues with it were around rescue request tracking and a breakdown in communication when Zello channels were too busy.
> At my job in 2011, every single member of my team was on using a different client...

This persists today - every single person I communicate with uses a completely different app, including SMS and email. I only know one person who uses WhatsApp, but serval have dumbphones.

Coordinating with more than one person involves at least 2 chat programs and a website. "Group chats" are impossible because in 2017 we still can't group chat between 1 person on Skype, 1 SMS, and a Facebook.
He has tutorials on Python 2.7, MySQL, PHP, Assembly language, C++, C#, Objective C, Java, Android dev, OOP, Design Patterns, UML, JavaScript, AJAX, JQuery, Angular, Git, HTML, CSS, WordPress, XML, Investing, Marketing... I watched some of the Android development videos. It helped for me to slow them down, but then I hardly listen to English lately. I did like that he used large fonts in his IDE and zoomed in on the text.
Talking to Seth Godin Changed My Life and Business
>>But if you run a website with open source software, you of course would still be liable for anything that happens to your customers' data. So you would probably want to buy that same open source software from someone (e.g. Red Hat), who would also be liable.

As others have said, this idea is really bad.

Red Hat will start charging obscene amounts to support the legal side of the license, especially if it is used in eCommerce platforms. What about the wife and husband who want to sell hand-knitted socks online, or small businesses who do less than $250k/year online? Will they be able to afford an alternative to the LAMP stack and fully shield themselves from legal liability and the horde of lawyers who will gladly step into any loophole?

Like many, my servers were affected by Heartbleed. So if I ran OpenSSL and someone found out before I patched it (took me 24h to do so), I could be sued in that window if I hadn't bought the license to Red Hat - oh, and how about all the licenses to all the open source software that depends on it underneath, OpenSSL being one of about a hundred of those projects? Do we license GNU toolchain? What if there are buffer overflow exploits found in various tools?
But if people didn't care about counterfeits, you could make your own cards, right? For any non-collectible card game, noone would care if the cards are "authentic" or not.

This is sort of like the difference between original art and a high-quality replica. Market value has its own logic that's often independent of use-value.
>Sure, but if you want to have real influence, you need lots of money.

Real influence for what? Power over people?

You can change the lives of people around you without "real influence" that comes from money. Not even need to do volunteer in some organization or whatever. Can start by being around for relatives and friends in need. Or some neighbor that has some problem -- perhaps they're old and nobody ever visits them, or can't afford even a basic medical procedure. Even political influence, if that's what was talked about, can be attained with almost no money at all -- just sticking to your ideas, telling people about them, organizing others to help, etc.

>We are talking about things like owning media conglomerates and shaping the way the world thinks and behaves.

Are we? Who the duck cares about "owning media conglomerates" -- if it wasn't for the money it implicitly also means that is?

TFA's author talks about feeling behind in his work/life progress, and the parent comment in this thread as well. How did that escalate to "owning media conglomerates"?

The idea that "owning media conglomerates" is really an actual important goal to achieve in life lest you just "run through the motions", is incredibly dismissive not billions of loving, caring, happy, heroic, etc people living totally normal lives. And even if it was valid, that just leaves around 100-200 positions in the world. Heck, 10,000 if you like. The rest 7 billion - 10,000 just go "through the motions", really?

Besides, the kind of people that do own "media conglomerates" were either already the scum of the earth to begin with, making their way up by being in bed with power etc, or become that in the process.
It saddens me that these folks will soon be made into political chattel and inevitably labeled as racist Trump supporters. Sad state of the country
And their wealth was distributed evenly? Hell yeah the poor would have it better, is this a trick question?
All I ask is the headline not be "Physicists want..." but rather "Some physicists want..." A couple of people I've never heard of don't speak of all physicists, in fact most

>[...] just shrug and say we have to live with the fact that quantum mechanics is weird.

In fact, I don't think it's weird, I think it's reality.
Different incentives. Imagine a programming language team composed of a bunch of world class experts (expensive) worked on an amazing programming language that was a joy to use for millions of programmers worldwide and got a lot of academic interest and free work on it in the form of research etc. and they sold some books / support / services / consulting / certification / sponsorship that covered their salaries but did not bring in any more money than that. You and I would be very proud to be the corporation/manager that "owns" such a team, even if they don't make us a lot of money or increase the price of our stock options. But LPOD looks at this and tries to design it into a huge money maker. He realizes he cannot turn it into a long term cash cow like Oracle RDBMS but he can squeeze some profits out of it for a few years until it dies. Some profits is better than no profits. So that's what he does.
Fun fact: Windows 7 is now older than Windows XP was when Windows 7 was released.
Once you start targeting public market holdings, it would just create an even stronger incentive for companies to remain private. Soon enough you'd have secondary markets for high rollers dealing in shares of private entities, which would be completely inaccessible to the average Joe - and congratulations, you've increased inequality. In fact, this is already the situation in technology investments to a large extent. Companies remain private for longer to avoid post IPO regulations and restrictions, and the only guys who can invest are the insiders who get the opportunity through their network. The companies are only pumped to the public when the ascent in value has pretty much diminished (SNAP, anyone?).
I was in Brazil during the WhatsApp ban last summer. It crippled communication, it was fascinating to see.
“That's just colossally egocentric and incompetent.”

You forgot narcissistic. And those attributes explain why.
Books are good if you do the exercises alongside each chapter. Blog posts are also useful if you need a breakdown of a specific technical subject. However the best way to improve, in my opinion, is to play in your mind with mental models of whatever you're studying. Thus, if you wanted to be a great programmer, I think you should build up mental models of many reputable open source software projects and play with those mental models. That basically builds up your neurons to quickly recognize patterns in new software situations.

It's like music. Play a lot, listen a lot, and you'll build up a mental library of riffs and sounds that you can use to build a song or phrase. If you play with software a lot then you'll see those patterns and become a better composer, and you'll also be comfortable answering questions about optimization, architecture etc.

But not huge on blog posts. Not engaging enough.
If one can create $1 million/year in revenue for $BIGCORP it's completely plausible that they could create $5 million/year in expected value on some better, innovative idea of they own (or a startup's). The only problem is that the second option comes with a double-digit probability of failure. Extremely progressive tax systems artificially distort this decision towards complacency and mediocrity.

You mention people are risk averse (logarithmic utility of money). I posit that that is only true for non-altruists. An altruist prefers to save 10000 lives nearly exactly 10 times as much as they prefer to save 1000 lives. Given a secure enough financial base off of which the logarithmic personal rewards factor is a non-issue, this is the primary driver for plenty of people that I personally know.
It is time to buy tulips.
Except I work at such one big company, and talk to its security guards, shuttle drivers, cafeteria cooks, every single day.

And what do they tell me?

That once this ends, they're headed to Whole Foods for another shift.
Or that they'll sleep in their car for a few hours tonight before heading to the next job, not seeing their kids.
Or that they're struggling to pay for their mom's medical bills and have no clue how they'll ever get out of it.

This NY Times article pushes buttons so well because it resonates deeply with what I, and many others, have been hearing every day since they've set foot in Silicon Valley.
Meh. A lot of those systems are in offices where there's really not been a compelling reason to have upgrade cycles less than 5 years. Even a first or second generation i3/i5 has more than enough compute power for anything in most office environments, and if a machine is sluggish day to day it's almost always addressed by taking it from 4gb (or even 2!) up to 8 at very low cost or by replacing that overloaded 10/100 switch in the closet. An upgrade to SSD may be appropriate for a few, but that gets close to the "just replace it" point.

If you're a small company paying for outside support having someone do the upgrade would likely have been $100+ per machine, for what gain?

I'd expect a surge of replacements this fall as Office 2007 goes EOL and systems get replaced instead of upgraded (unless there's a shift to Office365 subscriptions) since non-subscription Office upgrades will die with the machine, at least for companies with decent IT staff or contractors. Note that this is for small companies not doing volume licensing, which is its own separate and special hell.
I found that out very soon in NL where you see mostly Dutch cheese in the shelves and just a very tiny small section with "world" cheese. Cheddar cheese became rarity at home these days.
you re going way off topic . this is about AI discoveries which in retrospect were found to have been discovered by neuroscience. you 're complaining that a potential theory (which is only partially supported by evidence) might one day hypothetically be found useful in AI.
Please teach calculus before teaching trigonometry. There's no prerequisite to learn trig first, and forcing people to learn trig-calc excites many mathophiles but is a major turn off to other students. Calculus can be taught using just basic algebra, and most students will benefit from already understanding calculus, when they are learning trigonometry.
That makes sense. I really hope that takes off for you.

Regarding a CTO, though, maybe a business manager would work for you. That certainly sounds cheaper to me, and you'd still control the product direction if desired.
sure do - John Titor... I still think of him often he was an interesting piece of internet history/culture...and brought up lots of interesting questions...never did have that 2008 civil war...but 2017 looks close...lol
All Ultrasparc silicon engineers were already laid off, this is seldom a big news per se.

I just wish google bought Sun for its Java and mysql, personally I do not want to have anything to do with Oracle as much as tech goes.
Okay, so this is not a joke and apparently not an advert either. A dubious claim.

I'm so confused. Paris Hilton must be close to the last celebrity on earth I would have thought to endorse a coin sale. Who exactly is the audience, here? I've never even heard of Lydian coin before.
At the end of nearly all civilian investments, stands a consumer with their wallet out. Take them out, and you are left with unused infrastructure.
> instead of actually supporting POSIX

POSIX support is in the API, not the syscalls. musl libc places great emphasis on POSIX conformance. So if you ran a musl-based distro atop WSL, that should give you what you want, or at least something closer.
>> In FP, nearly everything you like about OO exists

Is there an FP pattern that's analogous to an immutable object? The reason I like objects has nothing to do with mutability or state, it's the convenience of organizing a bunch of related functionality into a named class. When I instantiate it, I effectively get a named value through which I can access a bunch of functions that have all been closed over the same immutable values.
Support is one reason. If your database goes down, they'll send a team of engineers to figure out what's wrong. If they have to, they'll bring in hardware to duplicate your systems, and have engineers working on it 7x24 until they find out what's wrong. Not many vendors can provide that level of service, and if your business requires it, you're willing to pay for it.
see also: https://qntm.org/files/hatetris/hatetris.html
"The C++ version has no pointers but instead uses value types. This means that all data is stored twice: once in the array and a second time in the hash table."

This is interesting. Are they using modern C++ and making use of moves and perfect forwarding? Or are they just throwing std::strings around and doing millions of copies (e.g. remember std::vector must support copyconstructable, so copy constructors & operator=) in the process? That would explain the allocations in C++ being higher perhaps, particularly if they're using the "wrong" containers. Why not sure unique_ptr or shared_ptr?

It is worth remembering that move constructors and assignment operators only get used in very specific places and you have to ensure that any constructors you write yourself are explicitly noexcept.
They still collect all the metadata. They know with whom you communicate, and how often. They know with whom you're in a group chat and the names of those groups. They know your profile picture.

(Disclaimer: I'm a bit biased though since I'm affiliated with Threema. I think privacy in day to day communication is very important though, that was my reason for quitting.)
> The growing environment is kept at optimal temperatures year-round by heat generated from geothermal aquifers
It will be interesting to see if theoretical physics and computer science converge at all over the next century. Intuitively there’s much to suggest that our understanding of computational limits on things (not to mention the idea that the world itself is a simulation of some kind) has analogs in fundamental physical limits (speed of light, quantum noise).
that the Solaris code is closed source and I can't point you at a github repo to show you all the cool things in Solaris.
Yeah, this has been a SUPER week let me tell you....
What you changed in your environment?

(I ask because I had same experience, except now that I am diagnosed I am struggling to find what I am supposed to do... I am kinda spinning in place without going anywhere)
I would experience accelerated battery use after system updates were installed. Same deal, as I recall: Something buried within the "Android System" categorization.

For my case, I found that a hard reboot -- turning the phone off and then back on -- brought resource/battery use back in line. That is, an additional reboot, after the one initiated by the update process, itself.

I never did encounter an explanation for this.

After my Nexus 5X -- whose battery life was already starting to shrink more and more -- bootlooped at about 1.3 years old...

Well, I look at my friends with iPhones that "just work" and last until new features compel them to upgrade their device. And it's increasingly tempting... (Just, I don't want to drop a grand on a phone, per the reported upcoming pricing for the iPhone 8.)
Well, until Snowden's dump, stuff like XKeyscore must have seemed enigmatic enough. I mean, I doubt that people disclosed that they'd worked or consulted with the NSA, or NSA contractors. So only people who had would have known what those acronyms / code words meant. Rather like a secret handshake or whatever.
Remember, if you are not one up, you are one down. - S. Potter.
> Oracle routinely sues its own employees.

For what?
I agree with many of those points, but they describe the U.S.'s actions before Trump took office. Since then the U.S.'s behavior has been exceptionally isolationist; for example, the U.S. withdrew from the Paris climate agreement, is trying to withdraw or renegotiate multiple trade agreements, wavered on NATO commitments, has openly stated they embracing 'America First' policy, etc. etc. etc.
The rents would increase everywhere the next year to capture all that new cash.
At this point one begins to realize that "Reaganomics" is more than just a dog whistle and actually had a huge impact on the working class.

It's a twisted joke that Reagan was just inducted into the Labor Department's Hall of Honor.[1]

[1] http://thehill.com/homenews/administration/347840-labor-depa...
"Alcohol: the cause of, and solution to, all of life's problems." -- Homer Simpson
Wow what a stupid article. Follow this advice if you want to end up destitute.

You can make a great living without a being a complete retard and taking needless mistakes. The advice is retarded.
Just imagine if this were just "how things worked at TBTF banks"? I would not be surprised at all.
I have a simple test before I subscribe to anything: I call the support hot line. If it is answered by a human who introduces themselves with their name I'll give them my money. If there is no phone #, if the only kind of support is a bot or some online tool then forget it. Companies that want to do business without interaction with their customers will not see my patronage.
Noooooooooo. I love that app.
Threema. Self funded, no investors. Hosted in Switzerland on own hardware. Focus is on maximizing privacy and not having/storing any customer data. (Disclaimer: I'm an employee/developer.)
I believe it was Cheney and possibly Rumsfeld whose organization, in the late 1990s, published a paper advocating invasion of Iraq.
Second this. Choose a good variety and plant in good soil and you will have lots of amazing tasting tomatoes, especially cherry tomatoes are super sweet if you let them ripen. I have been doing this for a few years in London and it's always rewarding - will grow a bigger batch next summer.
Tinder and the Dating Apocalypse (2015)
In case you missed Mayweather https://twitter.com/FloydMayweather/status/90045925678433485... this seems to be the trend nowadays. My guess is these scam companies approach these celebrities for a one time promotion deal, and since there's nothing to lose they just tweet it out.

I believe the "audience" is not so much different from those who fall for Nigerian prince scams.
Unfortunately, without a laboratory to test such hypotheses, that is all that economics (as we understand it today) can ever be.

Edit: also, TFA gives some good arguments for validity of the model.
Pretty much all you need to know about working at Oracle:

Making his point about the "creepiness," not only with Ellison but with Oracle's power structure, Gosling said he sparked a notion to try to improve morale amongst the Sun faithful who endured the Oracle acquisition. He said the company decided to rent out the Great America amusement park in Santa Clara, Calif., and allow the Sun folks to have a day of fun. Scott McNealy and Sun CEO Jonathan Schwartz signed off on the project that came in well under budget and all systems were go, Gosling said. Except a few days before the event was to occur, Oracle Co-President Safra Catz got wind of it and put the kibosh on the thing.

"Safra found out and had a fit," Gosling said." The word came down that Oracle does not do employee appreciation events. So she forced the thing to be cancelled. But they didn't save any money because the money had been spent - so we ended up giving the tickets to charities. We were forced to give it up because it wasn't the -Oracle Way.' On the other hand, Oracle sponsors this sailboat for about $200 million."
Bell Labs, Xerox Parc, nuff said.
San Diego Declares Health Emergency Amid Hepatitis A Outbreak
Fantastic! Started using it, just now.

One request :)

- Can you do some backup/restore system?
I am the coordinator of MadridJS, one of the largest JavaScript meetups in Europe. AMA
I found trigonometry a lot easer than calculus, which even today usually takes me forever even for what I'm sure are simple problems.
IMHO, Just apply a BSD license and let the community handle everything else. Wish AmigaOS 3.1 would have done the same several decades ago.
I would be interested if anyone knows about the connection between information theoretic entropy and physical entropy.

I think thermodynamics and statistical physics are really interesting. In Parallel Distributed Processing they discuss an extension of the entropy metaphor to learning and neural networks

https://mitpress.mit.edu/books/parallel-distributed-processi...