skysight-inc/HackerNews huggingface dataset:
And further, whenever anyone turns up to say "metformin is great", just point them at the studies showing that aspirin does a fair job of extending healthy life span in a variety of laboratory species. Arguably the aspirin life span studies show more consistent results than metformin, though there are fewer of them. And we all know what aspirin does for human life span.

For senolytic therapies, look at Unity Biotechnology's pharmaceutical trials starting this year, Oisin Biotechnologies' gene therapy approach, SIWA Therapeutics with an antibody approach. There are a dozen or so candidate drugs worth looking at, in addition to the non-drug approaches.

If you have the connections you can order any of the various senolytic pharmaceuticals today and try them. Though this would be unwise for the chemotherapeutics with animal data, since they are not friendly compounds, and worth waiting for a year or two to see how more targeted things like FOXO4-DRI work out in human tests. A year or two from now will be a great time for self-experimentation on this front, given the range of candidates and the size of the effects in mice where there is data. Today the situation is in an awkward state where some of the easier pharmaceuticals to handle are either going to have tiny effects or have no animal data, while the others still need human data. Still, I would expect medical tourism to flourish for these things quite soon: the drugs are cheap, the beneficial effects sizable.
I actually am happy for you that you feel that way.

Unfortunately, politics being what it is in the US right now, I can't be certain that my opinions would survive such scrutiny. It's part of why I don't have social media accounts other than LinkedIn (which is just used for job hunting). I don't want to accidentally say something so controversial that somebody will be motivated to take the time to dox me. So why bother sharing anything on the net?
At which point you have the government making the decision what to mandate.

If the service is important enough that it has to be mandated in some cases then why shouldn't it be mandated in all cases? If it isn't that important, why should it be mandated in any case?
What to do if you find yourself stuck in a crack in the ground underneath a giant boulder you can't move, with no hope of rescue.

Cut off your arm, then sell the film rights to it?

https://en.wikipedia.org/wiki/127_Hours
Bring some Canadian charm into your terminal, eh?
I like how this gets downvoted on YCombinator of all places.
I find it odd that all the reported consequences of global warming are negative. Why wouldn't a modest rise in temperature do some good in at least some ways? I suspect that that would not advance the demanded panic, and is therefore ignored.
> Paypal isn't a government institution

So tired of this argument. The fact that Constitution does not prohibit them from doing it does not mean what they are doing is a good thing. "It's not unconstitutional" is a very low bar to clear, and clearing it doesn't mean you are doing everything right - it only means you are not directly violating the law, which you should be doing anyway. Nobody should get any praise for just not violating the law. And paranoid panicky reaction to literature that mentions sexual relationships is idiotic on the paypal side, is just wrong. I can see how dealing with certain kinds of shady sites in adult industry may be a burden, but dreamwidth is clearly not one of them, and it can be seen very easily if somebody at paypal was willing to spend 10 seconds on it. They just don't care.

> They can choose who to partner with by whatever metrics they want.

And, of course, this is not true for a long time - there's a number of non-discrimination and social-engineering regulations that substantially limit by which metrics you can choose your customers.
Slight nit: you want to add http to that so it gets linkified.

Thanks for posting it. It's super-interesting. I always suspected the chance for my country (Australia) was _reasonably_ good. This bears that out. In fact it might even be higher (5%) than I'd expected.

That being said I tried like 6-8 times and never won. But that's not too surprising even at 1 in 20.

In fact I think I've only ever met one person who had won this. As it happened he was from Russia.
Pretty sure nobody in Charlottesville was actually at work at the time.
How is that legally sound?
> There are a multitude of mobile apps for consumption of HN, most of which solve the code-block-line-overflow problem by adding a horizontal scroll,

HN does that natively - just drag the code block around with your finger. Still sucks to use though, so > quoting is the way to go.
100% ? IIRC we might have prevented it with serious changes a couple years ago, but now it's going to happen and is already happening.
Vanguard is owned by funds that are owned by shareholders. Essentially, it's customer-owned. That's a very different proposition.
So, Canadian Desi, you want to go back to India to settle?
I recently installed a fresh version of GIMP (for the purpose of running the exporter script so I can import the layers from photoshop files into the Spine animation tool). I'm only using it as an elaborate runtime for that script, but my impressions are that the UI is basically the same as I remember it from 15 years ago. So, while it's features may have improved, the UI does not seem like it's improved at all.
Now we just need some phones to blow up while people are using them.
> C#, F#, C++

Ok if C++ is memory safe, what's a memory unsafe language then?

If concurrency units (threads, co-routines) share a heap they are not memory safe. In Rust they do but Rust provide compile time checks for make sure access is safe.

awk, bc not production level languages. I think you're being disingenuous there.

> the only thing that prompted you to talk about Rust is memory safety ?

Yes

> they bout emphasize memory safety", as if that was the only defining factor of a programming language.

If you know anything about both languages that's at the top of their features list, which I mentioned.

> I also mentioned FORTRAN.

Ah interesting. So initializing a variable in FORTRAN would put that in thread local / separate heap?
You've also just described modern times, unfortunately.

Our current era is pretty much that, plus the germ theory of disease, plus near-lightspeed communication technologies and rapid material transit.
I'm just super jealous every time I see they pay 10k over market on average.
I accept that it sounds intensely condescending and harsh. I present it as an alternative to either screaming profanity (which they hear non-stop, all day), or meekly accepting the "there's nothing that can be done" lie they are instructed to feed you to get you off the phone in minimum time.

Nine times out of ten, you'll get a dismissive hangup but every once in a while it shatters the script and you'll get a quick story of someone trapped in a bad situation and then a quick word of advice on how to proceed in a a way that will get results.

Its a rhetorical phone nuke. Use it carefully. I started using it about 5 years ago when I noticed that the "heartfelt plea" had utterly stopped working.

I also use it often when "Microsoft tech support" calls me to tell me that they have detected that my computer has a virus. Its a touch more appropriate in that situation.
Would you say that switching to Gimp added to your professional toolset, or enabled you to do anything that you weren't able to before? Does it make you more competitive professionally?
Sorry, can you flesh this out a little more? I'm not quite grasping how paying academics high wages is ravaging our country.
> Phones have indeed allowed people to both need and satisfy that need for constant stimulation. It's pretty sad.

Why is it sad? I think it's fantastic. It's the elimination of boredom and the ability to be interested, productive or entertained at any moment. It's not like anyone is forcing you to look at your phone. I'm quite capable of putting my phone away and staring into space if the mood takes me. Your communal TV example is rather more intrusive by comparison.
I'm interested in talking about it. Email is in my profile. I have a couple other apps in the same situation as well.
I read this as "Google Express is dead." I paid for the membership but never used it as it was sub par compared to Amazon Fresh, Amazon Prime Now, and Instacart.
I totally agree. The US should withdraw all its military personnel and equipment from Europe as quickly as feasible.
Carrying the sign is a danger now? How about printing it on your clothing? Must one cover up to go outside and only protest when one is licensed to do it? Could he have worn a full-body protest costume instead and traveled in it? If not, how is this more dangerous than a Big Bird costume?

There are multiple ways to handle a safety concern, one of which is just by talking to the individual and observing. Someone with a sign acting like all the other passengers isn't much of a worry, I think.
IF skin color did correlate to higher fraud rate or expenses for PayPal, then requiring them to service people of all colors equally would be unfair to the company. In this case PayPal is refusing service apparently because processing payments for the adult industry is inherently risky and correlates with higher rates of fraud or illegal activity or chargebacks, etc. Since the same issue doesn't exist for skin color, you can't really draw that as a parallel.
The original comment is condescending, and is not unusual on HN. To call that out is not rude.
Hi Peter,
I recently moved to US (from India) on L1B. While I was in India, I had an app on App Store and making small money. I developed this app in my personal time and this is not related to my job. Can I continue improving the app (in my personal time) while I am in US on L1B?
Sure, but it's not coffee, it's one cup of coffee - and you can immediately get another cup for yourself.

That said, they still often lose out in that comparison.
just saw your email in your profile... I'll make contact.
Religion is a tricky one.... It is mutable, but most people (a) don't change their religion in their lifetime and (b) use religion as a proxy signal for social identity, including many things that aren't mutable.

In practice: I'd take the bet that a white person of Muslim faith could get around a "no Muslims" rule most of the time. "No Muslims", then, can be a proxy for "no middle-Eastern looking folks".
Not likely, unfortunately: "Our proprietary pattern recognition algorithm efficiently detects even the latest web technologies and plugins used on websites." (https://www.whatruns.com/about)
C# 7 was release a few months ago. The video is just a prototype of what C# 8 could have.
Street cred
>I published in Science and Nature during my PhD

you have my admiration twice, then.

it doesn't count for much from me to you, i know.

but improving the human body of knowledge is, in a wide sense, its own reward.
I don't think that there's anything archaic about using SFTP to move files around!
Bill Nye the Science Guy Is Suing Disney
> If they are attacked we have to defend them and they know it. They would contribute a relatively insignificant amount if we were ever attacked.

If? In the entire history of NATO, the mutual defense provisions of the treaty have been invoked exactly once, and that in response to an attack on the US, and the non-US NATO contributions were not insignificant.
Do you really believe there is a conspiracy amongst the experts who study these things? Are there other areas of science in which scientists conspire to withhold information? If not why would you think this is the unique area of science that withholds information?
Solving a Danish Defense Intelligence Puzzle
I have recently tried Flutter and found it light and smooth.
The article explains the reason well.

I think Flutter is promising.
If you're a developer and want to help out, there's a list of GIMP bugs for newcomers here: [1]

More info on how to participate (including not only development of GIMP itself but also filing bug reports or creating web content): [2]

[1] - https://bugzilla.gnome.org/buglist.cgi?bug_status=UNCONFIRME...

[2] - https://www.gimp.org/develop/
> They would contribute a relatively insignificant amount if we were ever attacked

Many Europeans gave their lives in Afghanistan, responding to an attack on the U.S., and also in Iraq on a fools errand. The U.S. is the predominant power, but that doesn't make others insignificant.
> the UI does not seem like it's improved at all.

I've always disliked the large widgets (very tall buttons, sliders, etc.). Every now and then I look at some screenshots from the newest GIMP version and there's no indication they're going to change.
Hybrid sweet spot: Native navigation, web content
We detached this subthread from https://news.ycombinator.com/item?id=15099632 and marked it off-topic.
"things you should never do"
Many libraries only have online subscriptions to these journals nowadays...
> As a result it is very transparent what is sacrificed - e.g. you can find NICE [1] documentation on evaluations of individual drugs and treatments and their benefits, and documentation of the decision making processes of the NHS trusts, so they can be debated and used as a basis for deciding funding, or you're free to sign on to additional private cover if the exemptions worry you.

The decisions that NICE makes are not fundamentally different from the decisions that insurers make when deciding which medications and treatments are covered for various conditions, and in fact, you can find analogous documentation of these decisions from every major insurer.

> The difference is that those systems goes to great lengths to ensure that the decision is done based on clinical needs and objective measures of what achieves the most patient benefit for the available money.

Emphasis mine.

NICE is not operating in some magical world where "revenue" and "costs" are somehow not intrinsically linked with clinical decisions. They're doing the same thing that insurers do - make decisions about treatments based on objective measures of clinical outcomes, subject to a finite budget.

Ironically, this entire thread is about HIV, and HIV treatment and prevention are one area in which the NHS falls drastically short of what's available in the US both to people on private insurance and to people without insurance coverage whatsoever.
I just looked at the support matrix: IE10+. So it is reasonably supported nowadays, nice :-)
Are you sure they were in the military? I wouldn't be that surprised to see armed people in camo who aren't in the military at a Trump event. I think open carry is illegal in DC though, so if they had obvious weapons they were probably officials of some sort.

Also, were there other people in the station? Were you the only one asked to leave, or were they clearing the whole platform?

I ask because I was in DC for the inauguration and the women's march, and there were thousands and thousands of protesters with costumes and signs of all sorts. It seems weird that they would single you out.
It's always so weird to see maps from the arctic perspective. That these routes are all fairly close parallel lines, and moderately short by global standards, is so strange. I remember thinking the same thing when first seeing the ICBM routes from USSR to USA, how they just straight over the arctic and how counterintuitively close USA and USSR really were.
And even then, saying "this is the cost of a cup of coffee" is basically asking me to give up a cup of coffee to pay for their app. If you break out the whole logic argument, it's saying "I don't want to pay for this app", at which point the value proposition is "you know that money you were about to spend on coffee? Spend it here instead". I know they want to say "look how cheap it is", but what I hear as a budget-oriented person is "if you don't want to spend the money for it, just stop buying something else". My aversion to buying an app isn't how expensive it is, but rather how much I'm going to use it. Stop insinuating that I'm too poor to buy your product.

And like you mentioned, coffee is actually pretty expensive. Even at $1, if you drink a cup a day that's $30/mo which is more than the cost of GitHub Enterprise. If it's $5 for a cup and you drink one per day, that's $150/mo which could get me an absolutely massive Digital Ocean droplet. We pay an assload for coffee. Bad comparison.

And not to mention coffee is addictive; many people drink it because they feel like they have to, not because they necessarily want to.

Comparing your app to coffee is just an awful comparison all around.
I don't know about online, and it's pricey, but I got a lot of good information from attending training at Xilinx. https://www.xilinx.com/training/atp.html
Hello, fellow Park Slope yuppie!

Y'all have a good thing going. I just don't think the co-op model necessarily translates to that many scenarios. Park Slope Food Co-Op depends a lot upon volunteer hours, and operators are customers. I think that's been the distinction in every co-op or co-op-like that anyone has cited as successful. They're customer-owned as much as they're employee-owned.
Well I guess this is a classic case of the grass is greener on the other side :-).
Enjoy living in here.
Defends against who and what...

If US stops initiated wars, I bet the world can be a safer place already...
The original comment was written hastily. I clarified what I meant in a separate comment (my mistake for not editing the original):

>>> Yea didn't phrase that correctly. What I really meant was it's largely the standard stuff you come across if you spend a handful of hours browsing on the subject. But there is a convenience in having it all in one place and extra assurance in seeing it validated with actual research (Dr. Oakley is especially good at collating relevant academic papers/articles).

So what I meant is that the content mostly isn't earth-shattering for anyone who has already spent a decent bit of time trying to explore learning methods independently. I made the obviously poor assumption that the HN crowd would be disproportionately interested in that sort of stuff.

The course is longer than it needs to be in MY opinion. For instance, of the notes I posted, only about 10% was in bold in the native styling and that's the part I considered useful. I also noted elsewhere that the book is a better alternative.

People are always welcome to disagree (and many have).
Would applying for a green card on a TN Visa be considered a violation of the non dual-intent of the visa and prevent me from renewing/applying for TN Visa at the border?

Context: naturalized Canadian citizen (Indian born) on a TN Visa working in the states.

From what I have read, green card applications are determined by country of birth, and for India are upwards of 3 years. So, I would like to know if an application for a green card would jeopardize future TN Visas at the border.

Thanks a lot for doing this AMA, Peter!
There's some historical arguments that without fossil fuels, the industrial revolution doesn't happen and we'd never get beyond that block.

I.e. if man/animal labor is more effective than crude machines, then societies never make mass investment into crude machines and don't prepare large numbers of people working with said machines, so there's no stimulus that might ever reach fancy machines that might be actually useful. We'd have the same fate as the medieval Chinese society, which invented lots of nifty tech centuries before Europe, but didn't go beyond that to the industrial revolution for social reasons until the progress elsewhere forced the social reasons to change.
Since most of this thread has turned into comparing the terribleness of insurance companies I'll say it again:

A good said of less than legitimate identification documents are probably far more useful to someone needing urgent medical care than insurance coverage is.
Yes. It is now.

Legislation to make it illegal was an act of society deciding that an otherwise-legal business decision was so unpalatable it must be prevented. -- That's what makes it such a good hypothetical. You can ask yourself "if such business decisions were legal, should they be prevented or discouraged? And what mechanisms would be appropriate?"

So I don't understand your point. Yes, it's illegal now.

Are you arguing for companies to always operate as they see fit, as long as it's legal, and regardless of moral opinions of anyone other than themselves?

Are you arguing that there shouldn't be any moral-based laws to stop discrimination like this one?

Are you making a point that companies should be stopped from making immoral decisions with the force of law beyond the current limitations?

Are you making a point that the current set of groups legislation gives legal protection perfectly overlaps with the set of groups that that morally should have protection from otherwise-legal business decisions?

Are you simply being a pedant about the current boundaries of law without meaningful contribution to clean up the hypothetical or clarify the questions raised by the conversation at hand?
Do good for whom? Sure, some species might benefit even if it's a disaster for humans.
@korzun

I'll explain.

We use several signals like code snippets, filename, directory name, header info and several others to accurately identify technologies. However, there are many possibilities where this can go wrong even with few signals correct. Every time we detect a technology, we calculate a probability of its accuracy and filter out the rest. This system self-learns and improves the identification over time. Hope this helps.
You are only an "indentured servant" if you're not good enough in your field to demand a competitive salary. Please don't put everyone in the same bucket as you.
Do I have any chance of getting a H1B or any other kind of work visa with no formal education but a proven track record?
Sorry but this is incorrect.

I'm speaking as someone who went E3 -> GC.
been meaning to try exercism for a while, thanks for the reminder
Python absolutely kills Javascript in the library department (particularly when it comes to doing stuff with tabular data). In my opinion the APIs for the built in data structures are also more intuitive and flexible. The __method__ protocols are also very elegant relative to what Javascript brings to the table. Of course, if you aren't doing anything fancy with data this point is partially moot.

I do admit that Javascript's object and array destructuring is extremely nice. The combination of destructuring and the spread operator makes working with heavily nested JSON much more enjoyable than in Python.
The future of work and why it starts with entrepreneurism
Ram Rahim Singh: fatal clashes follow Indian guru's rape conviction
Enterprise apps and data visualization if you prefer, but I was actually curious about the broader answer for web.
My memory of DSE is that it parsed the entire document prior to doing any script execution; it didn't merely run the script when it became available. That said, I probably touched it only marginally more recently than you.
Cool! Happy to help. My contact info is in my account, or just use the chat on our homepage. Curious to hear what you think.
That has nothing to do with this article or your claim that Google is violating net neutrality by offering different networks for different prices.