skysight-inc/HackerNews huggingface dataset:
All fair enough. The two big immediate challenges in the field are i) that the tumor-derived fraction of total cfDNA can be as low as 1:10000 (stage I) and ii) that it is difficult to make Illumina sequencing more accurate than 1 error in 1000 sequenced bases (in which case the 1:10000 signal is drowned out). This paper uses some clever statistical tricks to reduce Illimina sequencing error; one of these tricks is to leverage population information, i.e. the more samples you sequence the better your understanding of (non-cancer-associated) systematic errors. This follows a long tradition in statistical genetics of using multi-sample panels to improve analysis of individual samples. There are also biochemical approaches like SafeSeq or Duplex Sequencing to reduce sequencing error.

Not-so-obvious point #1 is that the presence of cancer-associated mutations in blood != cancer. You find cancer-associated mutations in the skin of older probands, and assumedly many of the sampling sites would never turn into melanomas. A more subtle point is that cfDNA is likely generated by dying cells, i.e. a weak cancer signature in blood might also be indicative of the immune system doing its job.

Point #2 is that it's not necessarily about individual mutations, which are, due to the signal-to-noise ratio alluded to above, difficult to pick up. One can also look at the total representation of certain genes in cfDNA (many cancers have gene amplifications or deletions, which are easier to pick up because they affect thousands of bases at the same time), and the positioning of individual sequenced molecules relative to the reference genome. It seems that these positions are correlated with gene activities (transcription) in the cells that the cfDNA comes from, and cancer cells have distinct patterns if gene activity.
Nope. Nazi speech is banned in Germany cause they learned their lesson.
As an addendum to this, I'll relate my own experiences.

The YubiKey NEO-n (and I'll assume the more recent 4 Nano) are phenomenal if you can (semi-)permanently spare a USB-A port. The ability to generate TOTPs and FIDO tokens without having to dig out your keys is an amazing convenience.

Unfortunately I can't say the same for their 4C, which I'm using with the new USB-C-only MacBook Pro. The plastic it's made from begins cracking apart within a month of use, and completely disintegrates within three months, rendering the device inoperable. To their credit, Yubico has replaced my device twice so far, but how this made it past their quality control I have no idea.

I deeply hope they fix the plastic durability on this device, as well as offer a nano version with USB-C support that I can leave in my laptop permanently.
Indeed, if they've got an oligopoly then customer comfort is not something they're optimising for. In fact, it never was, in that customer comfort was just a means to attract a larger market share. If that's not a concern market dynamics demand a maximisation of profit including maximisation at the expense of, now irrelevant due to lack of choice, customer comfort.
It was not a debate really, it was a popular error that was much remarked upon. It was as much of a shibboleth then as people saying "SystemD" now is.
I don't really know what to tell you, there. Are you generally familiar with the C build process, and bash?

The only "unusual" things I'm seeing there are the $@ (target) and $^ (dependencies) automatic variables, the wildcard and patsubst functions, which have the description right in the title, and the general ``target: dependencies \n\t command-list`` format of Makefile rules.
I was surprised by this too, but Google is one of the biggest kids on the playground right now, so I guess it's natural for them to throw their weight around.

Obvious note: Outsourcing your stuff to a 3rd party like that is risky, and should be considered so
What do you do when the boycott is ineffective because the service has a network effect that borders on monopolistic that doesn't allow for others to compete?

How do you boycott your power company? There aren't a lot of options...

(p.s. thanks for the civil discussion).
I've never asked before reclining nor have I ever seen anyone else ask, ever.

As for laptops, I've completely given up on them on planes. It's just not feasible anymore.
ElixirConf 2017 is coming up in the US, and there have recently been some conferences in Europe.

Erlang's conference is coming up too... so people are gearing up and getting excited again.
Gnu xargs since circa 2009 has had a '-P' option that will let you execute simple tasks in parallel.
In the Netherlands a 6'4" male is in the 94.6 percentile.

https://tall.life/height-percentile-calculator-age-country/
That's a great way to put it! I am going to use that.
Maybe the meaning changed in the US. I'm not from/in US. I just use English.

The only country that was mentioned was Thailand, so I thought that "the country" would have a clear meaning.
Nah, I have fond memories of when it was all against MS Goliath. Common enemy, etc.

Apple and Google made a great partnership.

It's now 2017 and iCloud/web services still kind of suck while Apple continues to make the best OS and hardware (IMO, of course). We used to be able to have both.
I believe it's a combination of things.

- everyone gets a trophy/self esteem movement. We've been taught that no matter what happens we will be told it's good. We never learned to challenge ourselves.

- the move to socialising primarily online. It's very easy to find people who have the same opinions as you. People avoid useful discourse that allows both people to grow and become more aware. It promotes extremism on every side.

- a quickly changing world. The path our parents and grandparents followed to live a good life isn't guaranteed to work today. Blindly going to college and getting a degree is one of the biggest mistakes young adults can make today.

Humans are emotional creatures that don't have a modern guide to living their life.

There's two ways this can change: on the level of the individual or at a societal level.

The individual changes by realising their own needs aren't being met and taking responsibility for it.

Socially I believe things can only change by having something quite dramatic happen. Though the recession was something dramatic yet everyone complained about "the economy" rather than doing something for themselves.
Just a question, I don't have a strong opinion. I will say that you CAN buy double width by buying two economy seats, but cannot do the same for legroom.
Yep. My reaction to this article exactly. "Hm, I guess I get to keep donating to the EFF."
TLDR:

> In this paper, we present a new system called EKLAVYA which trains a recurrent neural network to recover function type signatures from disassembled binary code. EKLAVYA assumes no knowledge of the target instruction set semantics to make such inference.

> [..] we find by analyzing its model that it auto-learns relationships between instructions, compiler conventions, stack frame setup instructions, use-before-write patterns, and operations relevant to identifying types directly from binaries.

> In our evaluation on Linux binaries compiled with clang and gcc, for two different architectures (x86 and x64), EKLAVYA exhibits accuracy of around 84% and 81% for function argument count and type recovery tasks respectively.
U2F/UAF/Webauthn are a really interesting chicken/egg problem.

Right now, not too many providers support these auth protocols, even though they are more secure than current 2fa alternatives and provide a better user experience. The aren't widely supported because that costs development time and many of their customers don't have security keys.

Customers won't buy security keys because it's an added cost that isn't supported by many websites.

The author of the post briefly mentions SoftU2F at the bottom of the post, but it's important to recognize how significant SoftU2F is to the U2F ecosystem.

We're just now starting to see consumer hardware come with HSM's built in. Apple SEP, Intel SGX, etc. are examples of this. SoftU2F _will_ be able to leverage these consumer HSM's to do secure crypto operations - see the pull request at [0] about storing keys in the SEP. This will effectively put U2F and UAF capability into the hands of your average consumer with no additional cost. Things can be just _built-in_, which is what it'll take to start seeing increased protocol adoption across browsers and service providers.

I'm stoked about the future of security keys and the associated protocols. Both external keys and HSM's built directly into consumer hardware.

[0] https://github.com/github/SoftU2F/pull/29
What happens when /bin/sh is dash or bash? I despise /bin/sh, it is basically PHP. There isn't a terrible amount of basic functionality that would enable makefiles to cross platform (even cross distribution would be nice). Interacting with files, file metadata, processes, exit codes, etc.

Absolutely love your oilshell posts. Keep it up. I think a concatenative language would be great as the embedded logic for Make, but a Lisp would also work.
Why the Brain Needs More Downtime (2013)
A lot of airlines will let you pay extra for the extra legroom seats - my experience on Malaysian, Singapore Airlines, FinnAir so being an FF or paying for business isn't always necessary if it's just height/legroom. Width wise there's no answer in economy.
Look mate, I am sorry to break the news for you but the woman in front of you was totally within her rights to push her seat down. This is not something that is granted from the back passenger in a plane. BTW, there are seats with more space near the emergency exits that can be bought for a small fee. If you are big you may want to consider that.

Actually reminds me of a crazy bitch that insisted that I don't push my seat down, while at he same time had her seat pushed down (guess it is called "maximizing space"). But this was nothing that could not get fixed with a short yelling at her.
I've long had this idea to build a decompiler (a program that maps binaries back to source code) using machine learning. The problem in decompilation is that you loose information when you compile source code. Machine learning could help even recover things like most likely variable names. There is also tons of training data that can be easily generated.
Amazon Opens Alexa Voice Services SDK to All Developers
PlanGrid (YC W12) Is Hiring Android, DevOps, Machine Learning Engineers and More
It costs a lot, unfortunately. Sequencing is still fairly expensive, and the methods in OP are fairly complex on top of that.

There's also the interesting question of: if the test came back positive in a seemingly-healthy control, how would you know if that was a true positive or a false positive? It's still early in the game as to how to work up a cancer detected only in blood. The gold standard is tissue biopsy, but how far are you willing to go to hunt that down? It's a tough one.

Source: My spouse is one of the authors of the study in question.
Being rich is having enough capital to escape the trap of wage slavery that is a 9-to-5. It is really hard to fathom the idea of money working for you instead of you working for money when $15/hour sounds like a lot of money though so I understand where "a lot of people" are coming from. However, raising the highest marginal income tax rates isn't raising taxes on the rich. It is raising taxes on the upper middle class - the most highly paid of the wage slaves.

The Micawber principle (from David Copperfield) comes to mind here: "Annual income twenty pounds, annual expenditure nineteen pounds nineteen and six, result happiness. Annual income twenty pounds, annual expenditure twenty pounds nought and six, result misery." 20 shillings to a pound, 12 pence to a shilling, so the difference between happiness and misery is a single shilling (or 1/20 of a pound).
> I literally don't see how anything TDS says is physically harming anyone.

That's your fault for not knowing about their propensity to violence.

Their rally this week resulted in 3 deaths.
Oracle: “Opening Up Java EE”
True to their tradition, the legal disclaimer on the announcement is about half as long as the announcement itself!
Should strong encryption software be accessible and defended? Do not forget the fight for PGP.
ZFS - native encryption, resizing, bleaching | The FreeBSD Forums
<https://forums.freebsd.org/threads/56869/>

> I hope that FreeBSD will be not too far behind. …
Game of Thrones Season 8 Episode 1 Script Leaked – Digitalample.com
Someone who wants to publish an app to Android cannot easily go somewhere else to publish their app.

I do get your point and I understand what you're saying, but at the same time this is not the same as "if you don't like Twitter just go somewhere else to post your microblog", because Android users don't have any other alternative.
I thought that it disabled SMT, not the actual cores.
That would make it 16c/16t not 8c/16t.
also: much more screen-space as the keyboard doesn't have to take over.
All build systems suck.

You are trying to solve a Turing complete problem in a simplest low impact way as possible.

There is no good solution. Everyone will fall short in one way or another. Hence a new build system. The wheel never stops.
Have a look at the lesson on Make from Software Carpentry! http://swcarpentry.github.io/make-novice/
If you had a newsletter like "new dead website of the month" if something died, I'd sign up.

I also would appreciate a gallery of screenshot for each product to get a feel for what it was.
Did you enjoy build.rs?
I'll take it. It is going to 10x in a few months, right?
This almost happened to me. My screen got caught on the lip and started to flex. I barely managed to get them to stop in time
>Being able to write asynchronous (multi-threaded or not) code so easily using FP is most definitely not a pitfall.

Your point? You're saying this as if I disagreed with you. What are you trying to argue here? That FP is the better than imperative? Did I ever dispute that claim? Where are you going with this?
Naming things (2015) [pdf]
Seats are getting smaller and people (particularly Americans) are getting bigger. Last month I was in a full flight and I had the bad luck of having a 300+ pound man sit next to me. His physique extended beyond the boundary of the seat, taking probably a ~quarter of my space. The situation was ridiculous but all that the flight attendant could do was to be "sorry" because the flight was full. There should be rules against this. Big people out there - buy two seats.
Right, but the fault is still entirely with the airline, not the passenger who reclines their seat.
While I absolutely agree with you, it seems far more likely that native implementations by Apple, Google and Microsoft will dominate the market. Windows Hello is a great early example of this.
Apply Advanced Microsoft Excel Filter and Import Data to Worksheet from Access DB
There's a lot to unpack in your comment. I do want to address a few things:

> People told me that I was using a slippery slope argument when I said using the wartime powers act against "terrorism" was a quick sink to unjust presidential powers.

Is it different to you that the actions here were taken by companies, not by the government? To the best of my knowledge, there was no mandate to take these sites down.

> Be consistent

Sure, this is my original takeaway from the article -- establish clear boundaries, openly follow those rules when someone violates those boundaries. It causes confusion and uncertainty when you don't follow your published rules.
Supervolcanoes could be the key to our battery-powered future
With those buzzwords in the name? Quantum AND blockchain?

To the moon.
The hype is real.
Company Announces First SEC-Compliant Public American Ethereum ICO
No, I'm an idiot. It turns off one of the Zen modules, to kill the intermodule latency.
Forbes is ad-infested hell, here is an Outline link:

https://outline.com/mntwGu
Man. You are arguing with me as if I disagree. When did I bring up threads and locks? I'm just elucidating the problem Carmack brought up. Jesus.
In 7 months?
Hardware device brute forces iPhone 7 passcode
It was dangerous, but also their right to do. The CEO of Cloudflare called out his own action as capricious and not good practice, but he still did it. Because hey, they're literally nazis. And anyways, one of Cloudflare's major services is filtering out spam, noise, and malicious traffic...
TOTP is phishable. U2F isn't. It wouldn't be good for the world if TOTP became universal, as phishing would adapt.

However, the single TOTP hardware device for multiple sites that you postulate converges on the U2F design if you wrap the OTP in signatures so both sides know who they're talking to.
'Highly expressed' here simply means that the variants in question tend to be located in/affecting genes that are more active in CNS stuff, it doesn't refer to the variance explained. You could identify a gene which is active only in cells in a particular organ yet variants inside that gene might affect little in the way of differences from person to person. This is useful for giving mechanistic hints as to how the variants are having any causal effect; it's also a useful sanity check, as if the IQ GWASes were turning up SNP hits mostly in non-nervous-system expressed genes, it would be highly suspicious.

That said, one of the more counterintuitive aspects of GWAS is that it is possible to identify many variants which affect intelligence while explaining trivial amounts of variance - this is the central limit theorem in action on the thousands of variants, because on net in normal people most variants just cancel out and the genetic contribution to intelligence is relatively few variants (most people differ by only 10 or 15 IQ points, so even if most of individual differences are due to different sets of variants, and we know from GWASes that single variants typically explain something like 0.10 points...), you have to identify with great precision the effect of a great many variants before you start being able to predict anything in normal people (This is weird and counterintuitive and I don't yet have any good metaphors or examples which can make it immediately understandable.)

Finally, on the gripping hand, 4% is weirdly small because the same people with a smaller sample (albeit boosted using MTAG/genetic correlations) were able to produce a PGS explaining almost double the variance, 7%, in "A combined analysis of genetically correlated traits identifies 107 loci associated with intelligence" http://www.biorxiv.org/content/early/2017/07/07/160291.1 , Hill et al 2017, and just yesterday "Large-Scale [n=107k] cognitive GWAS Meta-analysis Reveals Tissue-Specific Neural Expression and Potential Nootropic Drug Targets", Lam et al 2017 http://www.biorxiv.org/content/early/2017/08/16/176842 turned in the same 4% PGS despite different analysis & sample size, so I am suspicious that the validation sample being used is misleading in some way such as using lower-quality IQ measurements. (One of the problems in using independent validation samples rather than something like cross-validation.)
Given that almost every original thought as we know it is a synthesis of many different pieces of data rather than a burst of light out of a void, your argument is based on some very liquid ground.
Hello. Could I interest you in Quantum Magnetic IoT Coin? It's got learning AI.
Why haven't other companies been able to get lawyers to issue similar opinions?
That seems like it could less destructively be done by setting CPU affinities appropriately. And, by extension, automatically through better kernel code.

Or is there more to it than that?
> Few months back I was in coach working away on my laptop and the person in front decided to jam their seat all the way back. I barely managed to move my laptop before the screen got caught in the table lip thingy.

If it was really pressing down on the top of the laptop's screen with significant force, wouldn't it push the tray table to extend toward you, relieving the pressure? Or are you not opening your laptop beyond 90 degrees?
How does this contribution differentiate from https://arxiv.org/abs/1604.01383? This work just seems way too early + applying quantum-safe crypto to existing Bitcoin ECDSA seems like an easier and more practical solution.
Can't agree more. Today it's Nazis, tomorrow it's not showing enough support for the chosen candidate. This is the one slippery slope. It's evident in PC-speech. Today's PC speech is not the PC speech from the 90s.

And it's not that I don't like Pc speech. I prefer it. But I also don't want it to be the only kind of speech one can use for discussion. Try and have any good philosophical argument without breaking PC boundaries.

It's a scary thing when one group controls the narrative of what is acceptable and unacceptable speech.
I'm not the GP, but I have a client who uses Lync. We usually have conference calls with three or four people, and someone always has an audio problem.

The screen sharing also seems to take a while to sync up. Worse, it silently stops updating somewhere in the call. Lync seems to have the worst real world performance of any screen sharing / conferencing app I've used.
I am a bit concerned that between the Scala, Dotty, Typelevel, and now the Reasonable Scala Compiler, that the Scala community might become fragmented. Hopefully the rsc's claim of "making our findings available to the Scala community at large" holds true.

Edit: should have keep reading before commenting. In their related work document:

>we are definitely not declaring Lightbend Scala dead. To the contrary, we view ourselves as complementary to Lightbend Scala and hope that our results will create new opportunities for the official compiler. We are planning to keep in contact with Lightbend to discuss our findings and facilitate technology transfer.
This only works if the confrontee assumes the same. Which is often not the case. People usually think others can read their mind, and don't communicate their issues sufficiently well. The natural response to that lack of information is to make things up to have a coherent mental model. Over time this model tends to diverge from the ground truth, sometimes exponentially. As a result you get conflict, assumed malice, and other kinds of misunderstanding. The frustrating thing about all this is without grounds to unconditionally assume benevolence of the other party (i.e. without being close friends), this is largely unavoidable.
This seems like a false equivalence to me, given that Google (et al) are not the government nor acting due to pressure from the government. I do understand and value the concern around legislating free speech, but I think different rules apply for governments and corporations.
Oh come on — you are violating AGF in guessing about the "attempt to sell…". It's far more likely that this "assume positive intent" idea and post is just by people who were unaware of AGF as an existing principle. Follow AGF and just help point them and everyone here to the worked out Wikipedia concept. No need to assume bad faith of the people writing "assume positive intent"!
Because dongles are a guaranteed money-maker.
Have there been serious contracts without major flaws? Not just basic token contracts, which would be better served with something other than a Turing-complete half-broken language.

We were considering implementing some of our blockchain IPO and corporate governance via a smart contract, but decided to punt on it. It's flashy, it'd help us raise more money, but it just does not seem like a smart idea at the moment. We'll use a basic ERC20 contract to account for who owns shares (and pay dividends) but nothing more involved than that for now.