skysight-inc/HackerNews huggingface dataset:
IgG is usually implicated in fighting off pathogens like viruses and bacteria. It doesn't typically cause an allergic response. IgE is usually implicated in fighting off pathogens like parasitic worms or mosquito bites. It's the antibody that regularly get confused and binds to peanut proteins and pollen. There is speculation on why the IgE mediated immune response gets confused. One hypothesis is IgE evolved much more recently and "needs more work".

The immune response to IgE binding is intense. Allergic reaction is an IgE response to a harmless antigen. However, IgE can be downregulated by repeated exposure to the antigen in question. If the body uses IgE too much (eg. from repeated exposure), it starts to replace IgE antibodies with the more subtle IgG antibodies.

The immune system is very fascinating really. IgE might be the key to effective cancer immunotherapy. Imagine if we could program your immune system to fight a cancer as intensely as it fights a pollen grain or peanut in an allergic individual. There is a lot of research in this area these days.
The article title is suspiciously ambiguous. It's almost as if they _wanted_ to encourage outrage and motivate people to click through...
all said and done I get around 6 - 6.5 weeks of vacation time when counting personal days, sick days, and national holidays.

I would love to have a full 7, but that's pretty unheard of in the US.
This is complete and utter nonsense. WW2 was started by the Germans under direct supervision and order of Adolf Hitler, by attacking Poland under false pretense. Later on Hitler attacked Russia despite a peace treaty he had signed, and yes, a large majority of the victims of WW2 were Russians who had the highest death toll among all nations.

Your comment and many others in this thread are a shame for humanity, and I mean that seriously without hyperbole.
Where that analogy fails is that IRL you still do enjoy police protection even if you can't afford private security. Even if they're not patrolling 24/7, the cops should still show up if someone's trying to burn down your unpopular place.
Costs are probably not that high anyway. For most logistic companies, volume determines capacity for trucks, not weight. Transporting a washing machine amongst other deliveries will not cost much more than other deliveries of that size (except for the additional fuel which is probably low). Carrying it in place can be done within minutes, not much longer than other deliveries.

That's probably also the reason why machines are cheap to buy online. If shipping was a constraint, buying at big stores would be cheaper.

Therefore, concrete can save some CO2 but probably not much cost. The cost of replacing faulty water tanks could be higher than the saved cost.
"Cancer" is such a broad term, with ~200 different "types". I agree that "cancer" is a huge problem (my brother had childhood leukemia at 9 months until he was about 6 years old), and its effects on the family cannot be understated. Unfortunately, we've only begun to scratch the surface towards a cure for very few of the 200 types of cancer out there.
My Journey from Struggling Actress to Successful Tech CEO
Cereal Box Solar Eclpse Viewer [pdf]
You should edit the submission description to make https://www.pullrequest.com/ a clickable link. I've seen that done for other Launch HN submissions.
Why not? Concrete is cheap in China and shipping is cheap right now.
How does anyone travel with less than two weeks time? I'm about to go travel and the two weeks I took seems too short!
Sure...that's a different thing though. Python 3's choice to introduce new types and change behavior of existing types means no automated tool can really decide what to do.

The snippet I posted is a little different in that it runs on both Python 2 as well as 3, but the 2to3 tools choke on it.
Note that this post links to the "about" page, and clicking on the page's title will take you back to the home page. It's a job board.
10% compound interest, compounded weekly?

I can't believe you made it a a year, to be honest.
So don't distribute the actual papers? Even a complete citation graph with basic info (title, authors, abstract, doi) and a link to the publisher's canonical version would be a very useful tool.
Spin zone: The Sun’s core rotates four times faster than the surface
The Winds of Winter finally get released (extra points if it is done concurrently with the second season of Firefly).
I guess we all had that FP click at some point in our lives, but then we got back to our regular (imperative) flow, hopefully as better engineers :)
> Keeping an LFS system up to date with security patches should be virtually impossible unless you set aside a decent portion of your daily free time for this task

It's really not that hard once you know what software is actually on your system. LFS enforces discipline because you're less likely to blindly install hundreds of useless packages just because your distro bundles them. On a nice svelte system, all you need to do is monitor a few mailing lists and decide if something is worth upgrading.

More often than not, you'll be able to patch your systems faster than a distro will be able to release an update, because the source is in your hands at the same time.
Ask HN: Thoughts on spintronics?
Any thoughts on spintronics would be great, such as the difficulties of realizing spintronics and anything else you might think of.
Where'd the title come from? This doesn't have much information about the value of college.

> Are companies willing to hire tech people who do not have a degree?

> I don’t know, but I want to get some answers.
> For these reasons, people should consider the possibility of starting a career in tech without going to college, and employers should consider the viability of hiring such candidates.

How does this differ from the status quo?
Are there torrents or similar available of SciHub's collection?
/r/marijuanaenthusiasts/ is my personal favorite (its a tree related subreddit, since /r/trees was already taken)
WWW.JEZTERAPP.COM
Had no clue what nonplussed was and went searching. Interesting read: http://www.punctuationmatters.com/nonplussed-definition/
The domain is in limbo, not the hosting. They already bought a new .ru domain and created a tor hidden service apparently.

Whenever I see yet another article about that site, I think of the free advertising they are getting. It used to be a fringe site nobody had heard of but now that they are the media's public enemy #1 they've been elevated to mainstream status. Reminds me of something James Randi once said about debunking fraud psychics on TV, it didn't matter what he proved about them, people just saw the psychic on TV and immediately signed up for whatever they were selling in droves so he stopped doing it.
I doubt its a kickback.

It's probably a more strategic decision to standardise on one stack.
Gotcha, when he said "due process" he didn't mean it in the legal sense, but in the "we have to follow the right procedures internally to make sure what we are doing is right" sense.
I've never been convinced about the idea of serious engineered failure for this type of device. I think there are two problems, both consumer-related; price sensitivity (adjusted for inflation, these machines are far cheaper than they used to be) and demand for features (more modes, smartphone integration, bigger drum, higher spin speed), and something has to give.

If you compare a low-end washing machine, say a Whirlpool or Inndesit or something, to a mid-range one (Bosch etc), to a high-end one (Miele), it's immediately obvious what's going on. On the low-end one, costs are cut to the bone; everything feels flimsy. The door, the drum, even the buttons feel cheap and flimsy. The mid-range one, things feel better (and repairs become easier; easily replaceable drums etc). The top-end one feels like an industrial machine (and durability improves; high-quality motors, the afore-mentioned iron counterweight and so on).

To a large extent, with washing machines, you get what you pay for (as long as you avoid smartphone integration and other nonsense). There's consumer demand for really, really cheap ones, so manufacturers make them, and they break quickly. You can still buy a top-end one which will last, but it'll cost you.
Scheme.

Simple, strongly typed, and really really easy to write and read.

On top of that, its fairly easy to compile as well, which gets rid of a bunch of distribution problems that come with other Lisps.

My first in-production experience was converting a monolithic Python web app to Scheme.

We wrote a library that brought a lot of Python conventions over to make things easier. Like an import macro that automatically namespaces things. (And we copied Clojure's "->)" macro for closing all open parentheses).

Total conversion for ~18,000 LOC Python to ~7,000 LOC Scheme took about nine weeks. The speed-up was about 2.5x.

And despite the much smaller codebase for Scheme - we actually added a whole heap of features, whilst matching all old features. (A bug or two as well, but that's to be expected).

Scheme is just really well suited to parsing, and rewriting itself as necessary.

So far as I'm aware, that stack is still running three years later, so Scheme wasn't just a fad for the team (who picked it up in about a week or so).
I'd still think it's awful because I don't see being gay as a bad or immoral thing - there's pretty much no imaginable situation in which allowing gay people to exist unhindered causes damage to anyone. I'd suggest that if being gay were a conscious choice, the shop should have a right to refuse service to gay people, but again, I'd have a right to stand outside their shop with placards, shout about it in the news, etc etc.

On the other hand, allowing neo-nazis to go unhindered may quite reasonably result in people's deaths, so.
Mine too, but it took years and a fairly complete change of people I interacted with and longterm exposure to various ideas and life experiences. It was not a decision/choice. This kind of change is a long process of learning new ways of thinking and abandoning the old ways.
Other than not having to write another app, what are the advantages of something like Elixir/Drab over react/(relay/redux/flux)?
He talked about a whole FP-powered architecture to solve this.
> In the 5th or 6th century. Christians were doing the same in the middle ages. Is that true of the Islam and Christianity people follow today? No.

All that is still there in the scriptures. Not many people are "doing horrible shit" to people in the name of those religions/ideologies today, sure (though do look at how the Islamic world treats apostates or women) - but nor are today's Nazis doing any extermination in practice. The idea that people in one movement whose core beliefs include support for genocide must really believe in it but people in another group whose core beliefs include support for genocide must be into it for other reasons seems rather dubious.
Yeah, the smoke is considerable, and smells delicious. Definitely an outdoor activity (or be near an open window w/ a fan).
Universal basic income.
The title is pure link bait. Why not use the original title "Tech Jobs Without Degree"?
Huh, I thought Bosch still had replaceable bearings. That's disappointing.
Link to the original 2013 study http://www.jacionline.org/article/S0091-6749(14)01737-0/pdf
I was referring to primarily text/emoji based, person-to-person apps/platforms (similar to Allo). That's why I listed only WhatsApp and FB Messenger and intentionally ignored the other ones.
I'm surprised the article makes no mention of this book which covers the exact topic extensively, and which has (AFAICT) received a lot of exposure and publicity.

https://weaponsofmathdestructionbook.com/
>By the mid-90's it was trying to compete against IT rags that were definitely for "mass" consumption.

Yes, I agree that BYTE eventually expanded (or diluted if one chose that viewpoint) their coverage into areas that overlapped with PC Magazine etc. But they still had more of a niche audience. Here's an example issue from 1994.[1] If one flips through the pages, it has stories about CISC/RISC and Object-Oriented COBOL. It also has ads for a disk hex editor and Watcom C++ compiler. The typical computer enthusiast that's playing around with WordPerfect/Lotus and games like Microsoft Flight Simulator didn't care about geekier topics like that.

My first IT director was a programmer and even he didn't subscribe to BYTE. He did subscribe to PC Magazine and ComputerWorld.

[1] https://archive.org/details/ByteV19N9
I am curious if the law is enforced more strictly now, because the son of the long time king seems to be a drug addled loser, who took the throne in late 2016.

http://www.thedailybeast.com/prince-of-thailand-maha-vajiral...

Could the lesser amount of respect for the new king, and the increase in enforcement, be linked?
I re-read what I wrote, and I believe I was clear.

Here is my statement

> , in the face of people intentionally releasing material designed to hijack human brains via emotion.

And then later

> They aren't debating Marxism or porn. They're trying to drown out other ideas, and to tie Down people who present cogent counter arguments.

>Want a non tech example? Take a look at anti vacc or creationism.

How you went from there, to

>Wait, so you're saying censoring creationist and anti-vaccine sites is acceptable too?

I am not sure.

SO let me re-iterate my main point.

The battle being fought right now, is between people who are using techniques to stymie actual discussion and actual trade of ideas.

The idea is to "hack" the human brain, to target emotions, logical errors, rhetoric and so on, and to then build a block of people who can be counted to work together.

The active target is free speech itself, science, and so called "liberal" values, which is now just a label for an ever expanding field of targets.

You want to look at creationism and anti vacc to study how those non factual ideas were propagated.

Remember that these ideas won in the country which had the greatest claim to carrying the torch of civilization and science.

You look at those topics for study, not censorship.

You then understand the techniques used once you study those topics.

Once you do that, you realize that this is not about free speech, and that nothign in free speech can really deal with what is happening.
I didn't go to college. I started teaching myself when I was 10 to write PHP/MySQL/HTML/CSS/JS. I got my first "real" job when I was 18, fresh out of high school. I'm now nearly 22, making more than either of my parents, with no student debt, and I am so glad I didn't decide to go to college.

My advice is to take a gap year before college. If you can become gainfully employed during that gap year, why bother?
Support a Great Partnership: PyCharm and Django Team Up Again
100 miles per gallon cars.
Oh, yep, it'll do a better job than the cheap stuff. Most people just aren't willing to spend this sort of money on an appliance, though.
How to go from paper wireframe to interactive prototype
I don't have kids yet, but I just wanted to thank OP for starting such an interesting thread. Definitely bookmarking for future reference.
This, but I also think we can't just do this in a pure "freedom of speech" way. In order to have a space where we can talk about things calmly and respectfully we will need to shut-out "bad faith" actors, supremacists and ideologues. Otherwise they will pervert the dialogue in order to win some political battle and we risk the wrong outcomes.

We have to come at this very directly from the perspective of the outcomes we wish to achieve and those that we wish to avoid ("consequentialism") rather than through some mindless repetition of an ideal that we believe to be sacred ("free-speech is so important"). Free-speech might be important but maintaining peace and achieving good outcomes for all involved should probably be held in higher regard [0] than some abstract principle, particularly when that abstract principle is a shibboleth of the people on one side of an issue but not the other.

[0] I'm talking about people that want to argue about racism and sexism while incidentally subjecting those they're arguing with to the most extreme and potentially toxic people in their group in the name of 'free speech'.
I used to be a Vonage customer (service was nice, as long as my Cox internet was working - but I shut it off after my wife and I finally both had cell phones - this was at least a decade or more ago).

I had always wondered how you guy's were doing it, but I had always thought that the router Vonage handed out was something special that used its own reserved ports or something that wasn't easily visible. I never looked into it deeper. It's interesting that instead something like this "hole punching" technique was used.

I've heard about the technique before, but never investigated it before...
I agree. The point is that one's political orientation is not a simple choice no matter how radical. It may not be as fixed as sexual one, though, but still difficult to change.

It's kind of a water a person swims in. It's the way he thinks. It's too meta for most people to even think about it as something chooseable.
I believe you have the right to express your views freely and I agree with you that violence on any end of the spectrum is unacceptable. Groups like Antifa and BLM have legitimate grievances which their violent actions completely undermine in my eyes. The narrative of the "middle class rural uprising" we've been presented with as the reason for Trump's election has, at its core, exposed perfectly understandable issues regarding middle American economic and political disenfranchisement, which have unfortunately been taken up as a banner by white supremacists, and twisted into a justification of their ideals.

However, I have to object to what I see as an attempt to portray yourself as a politically unbiased observer:

>Friends of mine are members of both Left and Right-wing political parties in my country, and I refuse to be associated with either, because parties and wings create division and move us further apart, and distract us from the same values that we do share.

Prior to this, you assert that "the Left" is "the only group wanting to stop freedom of speech, and impose tyranny on all others." Earlier, you refer to the "tyrannical Left" and mention that you consider James Damore to have been a victim of censorship, and their "(obviously) intellectually lazy and inaccurate narrative."

You may reject political parties but you appear to disagree with one ideological wing far less than the other. Such language only serves to poison the well, and encourage exactly the distraction and emotionally charged polarity you claim to oppose.
Reminds me of reddit.com/r/stormfront which is a subreddit for storm photos.
But China abandoned socialism in the '70s. It's only been since then the country started to turn it around.
An interesting animated video on disciple:

https://www.youtube.com/watch?v=cPn3UOt1lxw
Clean Architecture in Django
Code hot swapping is not particularly friendly at all. It's impressive that you can, but the time required to write the code carefully enough and QA the upgrade doesn't seem to be worth it for most applications.

Sure, a telco switch that has to be up 24x7, hot swapping makes a lot of sense. Most applications can spare the brief downtime to reload the old-fashioned way (or have multiple servers to allow upgrades to be done without downtime).
For a bit of extra anecdotal evidence - in Israel a common easily-digested semi-junk food is Bamba, peanut puffs. Rates of peanut allergy are very low there.

What you have instead is milk allergies, and briefly doctors recommended delaying introducing milk to infants. (This advice has also changed.)
One of the amazing things about X was how easy it was to snoop on others. There was one prof at my university who appeared to be working long hours until a grad student came up with the idea of dumping out the prof's frame buffer - and it turned out he was playing Tetris! Default settings were very permissive...
Hi,
eul is a very lightweight and fast native desktop client for Skype, Slack, Gmail, HipChat, VK, FB, Jabber, Telegram, and Signal. Right now only the first four are supported, and the rest should be done by the end of September.

Why did I create this? To solve two big problems I see with the current IM solutions: there are too many of them, and the clients are ridiculously bloated for what they are built to do. For example, everyone knows what a huge resource hog the Skype client is. Even the Telegram client, which is supposed to be lightweight, is using 1.3 GB of RAM on my desktop right now.

I'm obsessed with performance. The entire application is about 4 MB, and it's never going to be more than 10 MB. In fact there are still many things to optimize. It's native, so you don't need to download a 100 MB browser just to use your IM client.

eul can display thousands of messages in one conversation without the constant page fetching. The scrolling is instant and smooth. You can jump to any message without waiting. I've tested it with 50 000 messages in one chat. No lags, instant scrolling to any point, instant search. That should be enough for most :)

This is a beta release. Some essential features are still missing (for example, images and other attachments are not supported yet). Automatic updates will be released every day. There's a built in contact form, please use it to submit bugs and suggestions.

Looking forward to hearing your feedback.

Thanks
CloudFlare is a private business. Its their prerogative. The only thing the CEO did wrong here was explain himself.
I'm sure those Nazis can figure out by themselves why they got tossed out.
This was a keynote at a Quakecon, a conference for game players, not a technical presentation for software developers.
This is a good one, to add to this I would love to see 4 day work weeks become more popular in the US.
That being the case, we still can't rule out the possibility of general-purpose treatment methods.
If your only definition of "value" is "monetary value," I think you have larger issues. To quote Oscar Wilde (over a hundred years ago, to boot):

Nowadays people know the price of everything and the value of nothing.

To me, college was extremely valuable. College forces you to interact with people and ideas that you either disagree with and/or were completely unaware of. It's the single best way to reduce the number of "unknown unknowns." Was it overpriced? Yes. Were the loans "worth it"? Not sure. But the solution to this societal problem is surely to make attending college more affordable, not to erode the fundamental importance of an educated society.
Why not make everything free? That would benefit the customer dramatically. The reality is that 'customer first' is a good idea, but not actionable.
Sorry to hear about your daughter's healthy issues. For a while I've been dealing with food intolerance issues myself though things are much better now. One working theory I have is to have a high protein diet to build up the the lining of the gut. Maybe incorporate more high quality protein into your daughters diet and see if any improvement. I have no scientific evidence for this, just anecdotal experience... I don't think even doctors have all the answers based on those I dealt with.
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Major revamp of the Google app starts rolling out to Android users
Gitlab.com offline
I think we need biologically inspired robots. Have you seen a ground digger wasp (Eastern Cicada Killer)? They can mine many times their body weight in hard soil each day.

Landing pods on the surface and then covering them in regolith is going to call for heavy machinery. A boring machine is also heavy machinery. These cost an enormous amount to get to Mars. But insect-like robots over a large timescale could do the work at a lower cost.