skysight-inc/HackerNews huggingface dataset:
>Our rapidly growing species has only accumulated mutations that don't cause us to die

Hygiene, nutrition and medicine (all good things!) also cause us to remain alive where previously natural selection would not have favoured those bearing too great a mutational load.

I doubt that existing mutations have been fully 'tested'. We know that the majority of mutations are harmful and that the brain is far from fully-developed prior to birth, for instance. Being complex there are many genes which control its development and it seems plausible that the result could be sub-optimal without obvious signs of disease or disability. Other things being equal, we could be slower, less resilient, less fertile, etc, than our 18th century forebears.
Foxconn has more factories in China than in any other country and their largest factory is in Shenzhen.

The implied "Made in USA" vs "Made in China" is fair.
Seems like a repackaging of the arguments against socialism. Arguments which are ridiculed here on HN "Just because most socialist states collapse into hotbeds of corruption doesn't mean it will happen here!"
Twitter's spending is just bonkers out of control. And from my understanding, they haven't even tried to curb it. Twitter could be a happily profitable company if they just shed some of the fat.
what you describe just shows that the old business model - pill in exchange for money - starts to show its limitations in the globalized world. Facebook would never get where it is now if it charged $10/year in Africa and $100/year in US. The pharma company who figures out that new business model would become that trillion dollar company.
You can actually work out roughly how far away the horizon should be surprisingly easily. Just use the fact that if R is the radius of the Earth and you are at height h, then from you to the horizon to the center of the Earth back to you is a right angled triangle with one side of length R and the hypotenuse of length R+h. Therefore the distance to the horizon is sqrt(2Rh+h^2) which is roughly sqrt(2Rh).

The Earth is roughly 6370 km which is not far from 6400, so if your eyes are 2m = 0.002 km up then the horizon is about sqrt(264000.002) = sqrt(25.8) km away, which is roughly 5 km or a bit over 3 miles.

If you apply this to a 6 km tall mountain, the horizon is about sqrt(263706) km away which is about 276.5 km. So something of the same height at the opposite end of the horizon would be 553 km away. So the top distance of 538 km is pretty close to the maximum that we would expect.

What about an airplane? An airplane flies about 11 km up. So it can see around 375 km. If you work it out, that puts the horizon about 3.37 degrees below horizontal. This isn't much, but if you take a plumb line and a right angle on an commercial flight, it is enough to actually see that the horizon is below horizontal.
Ask HN: How do you keep your energy level up?
I recently graduated and started a full time job as a software developer. By and large, I love my job. I usually spend my days solving interesting problems which is what I love doing.

That said, after working 8 hours a day (I usually do 7-4 with a 1 hour lunch break) I find myself exhausted afterwards. I sometimes find myself going to bed not long after dinner. I don't have time for any of the hobbies I had in college like gamedev or video games despite having a similar if not greater workload in college.

It seems like the main difference is that the work was broken up by classes in college which spread the work out more and made it less exhausting.

To be clear, I'm not talking about "burn out", at least not in the sense that it's normally talked about. I still love my job (I just started!) and the work it entails.

I take vitamins, and I get a reasonable amount of sleep each night (7-8 hours). I tried working out but that just seemed to make me more tired.

As I look at my future, I hope to one day have kids and get married, and I'd be a pretty poor parent if I came home with this level of energy every day.

So how do you do it? Do you have any tricks to keeping your energy level up throughout the day?
Mostly due to it being "mobile devices" - where every major platform has good support for IPv6, and the carriers need a massive amount of IP's - which are simply not available.
I was only addressing baking while camping. As a man, I also bake while I'm not camping, like many other men.
Shit. If David Cameron's pig story was Black Mirror coming true, this is Orphan Black's moment.
I think your use of it is pretty clear, but it's interesting to note that quotation marks are also used for scare quotes. Two possible usages in this case with almost entirely opposite meanings.
Why is this even a consideration, people seem to create a new one every now and then and become all giddy about it. If there is no shortage, we should not be creating more humans. I wish human birth was more regulated. Once born, if people can't afford, properly maintain or educate their kids, it automatically becomes government's problem to fix, with all of us having to pay with taxes or otherwise having to live with. There is little if any, personal or economic benefit to having created one as individual.
Some terminals (like urxvt) also support running as a daemon and spawning a new window just attaches to that terminal daemon. Faster and it saves you a megabyte or two over actually opening a whole new terminal.
Surely You're Joking, Mr. Feynman!

Edited biographical anecdotes based on taped conversations. If you've enjoyed any of his videos, it's hard to read and not hear his voice telling the stories. I'm about a quarter the way through and am enjoying it so far.
We detached this subthread from https://news.ycombinator.com/item?id=14849089 and marked it off-topic.
That should just about cover Trump's first term.
I think it's a mistake to describe it as taxpayer financed. The text I see in the article is all about a reduced tax bill.

"$1.5 billion in state income tax credits for jobs created, up to $1.35 billion in credits for capital investment and up to $150 million in sales tax exemptions on construction materials"
Dogs are fertile at 1 or 2 years of age. You can do an awful lot more in 100-150 generations than you can in 10-15 generations (probably more like 6-8. Checking my family tree, many of my great-great grandparents were born ~1850, so for me personally, 5 or 6 generations).

In any case, we have to go back to the question that the GP asked, that dogs are malleable doesn't help us. Does reduced child mortality really cause more mutations to accumulate?
Ethics questions need to be raised now, and guidelines have to be decided. The future of humanity is in gene editing. It should not depends on the lazyness of law makers and outrage of godfearing creatures to decide the fate of humanity. It is time we take our evolution into our own hands.
The state didn't; market forces did (ie insurance companies).
Better math is one good reason. Grammars are also a great feature of Perl 6.
Well, only if you want to explain away the fact that the Estonians should have won the tender based on the official scoring and criteria. In other words, you are rationalizing. There's a reason why tenders always have a fixed scoring system. And this is it.

Maintaining good relationships with the Russians wasn't part of it, of course. We'll pay them enough for Pask2 (awarded without tendering). But even if not, because enough does not exist, more is always better, if this is the price of a 'good relationship' then we already have a bad relationship with them. I.e. they are blackmailing us. (Of course, it's not the case, but they are probably more willing to pay back than the Estonians...)

No, these problems are not like other problems, though Siemens and Alstrom were also both involved in corruption cases (I mean outside of Hungary), these are more serious and didn't happen with the others. It's not simply only integration problems.
Macdown is nice. I use markdown and vim for my journal and use some shell aliases to create the files with some snippets. Macdown will be a good addition.
But in that sense it's not literal at all. Again, chemotherapy.
Doubtful alot of the Recovery Act was for One Time Construction projects, like paving a road.

There were also alot of one off projects like sending people out to help with Energy Efficiency in homes.

There was not alot of long term stable jobs in there.
This is why I still suggest keeping it on ext of some method and then just backing it up to zfs. Though now I'm wondering if you could put a raid1 on a zdev that matches the real disk and get benefits that way.....
Sourcegraph founder here. We love it. The more developers who are using code intelligence in their tools, the better the language support will be for all the various languages and repositories out there. That's good for developers everywhere, and we (Sourcegraph) could never build it all alone.

Our master plan at https://sourcegraph.com/plan describes what we're building on top of these basic "code intelligence" primitives, to help developers in all of their dev tools (not just GitHub), in all of their workflow, and in companies that have lots of code. And just like GitHub, we let people use these things for free on open-source so they can see how useful they are.
Tarpaulin – Rust code coverage tool
Says free now, which implies not free later. How do you compare with the numerous other similar services?
I'm not making a formal claim just sharing my thoughts. Though I do believe at least one evolutionary biologist has written about this: Hamilton W.D. (1999). The hospitals are coming. Narrow roads of gene land (Oxford University Press). Btw the phenomenon of 'mutational meltdown' is a closely related topic and may re-pay googling.
So I just subscribed to WSJ online to read this article. Went to cancel my subscription before it renews for next month. There's no option to cancel! You have to call a US phone number. I'm from the UK. This should not be a thing in 2017.
Ether Tokens Are Likely Securities (2016)
I'm dying to hear you expound on exactly what Marx actually says and why what he says shouldn't be taken seriously. Cites and quotes while you're at it, please. (No third parties, please--he clearly doesn't need the help.)
I feel like Katie Moussouris switched from SDL to bug bounty stuff at MSFT in like 2011, but I may have the dates fuzzed up a little bit.

Really the only point I want to make is that this is not Microsoft announcing their first bounty program.
> Point being, there is no reason to hold any of these chemicals to a standard higher than that of a strawberry - that is, we can give people a bunch of strawberries and say any negative effect is below some acceptable level. And, in fact, we have found many "natural" foods containing absurdly high levels of arsenic and other dangerous compounds, and that has affected their preparation for consumption. The scientific process has in this way even outperformed the naturalism heuristic.

That's incorrect. We've coevolved with many of the foods we eat. Things like strawberries and broccolli have been, more or less, with us for thousands of years. While it may be true that there are harmful components of those foods, we know that eating them is at least not making us worse off than we were. When introducing some new chemical, we really have no idea what its effects might be. And we have no, in principle, reason to assume those effects are benign. We've had a very very long time to adjust to the organic components of most foods.
So your considered recommendation is for 60% of recently bought device owners globally to all replace their phones, tablets and laptops with devices containing Qualcomm chips, immediately.

And this is preferable to a software fix.
The rocky road to Emoji 4.0 support
Why would that be crazy? Snap is new to the game and their active user base is an order of magnitude smaller than Facebook or Google.

If Snap starts showing signs of accelerating DAU/MAU growth, then there's a chance that they'll be >1% of the market.
Modalert, caffeine, workout about 3 days a week, consume a small amount of carbs(smoke sativa weed instead of drinking beer before calling it a night), and a very fast internet connection.
I barely use Facebook anymore. Are there any reasons other than user growth to justify the profit jump?
This seems unlikely. (Or maybe that's the reason given, but it seems implausible to be true.) Competitors have more than enough know how to determine if you're infringing a patent, source or no source.
Uh, sabotage? The author indicated that this company underpaid employees and treats their needs and quality of life with indifference.

If you're talent is a resource, then the company mantra should be "We are lucky to have you as an employee" not "you are lucky to work for us as your employer".

That, or actually make the place a lucky place to work. Pay well, provide great benefits, create a great workplace. There is a HUGE difference between saying people should want to work for you vs. actually being a place people want to work.
Hawaii would be where I'd start looking for that.
I think you're misunderstanding my point, but maybe I shouldn't have taken vertebrates as an example; we can of course imagine some island where massive selection pressures lead to speciation. I would be interested if you have such an example.

However, dog breeds are not species and, given their non-random mating, don't really tell us much about whether 200 years is long in vertebrate evolutionary time.

As far as humans go, I will grant that allele frequencies may have changed if you pick an isolated subpopulation of humans (say, everyone in Greenland) but even that seems extremely unlikely.

As an aside, there are researchers who are using the caste system in India as a way to explore genetic architectures within a civilization. As these castes have existed for considerably longer than the period we're discussing, meaningful allele frequency changes may arise.
How, specifically, is iOS "security by obscurity all the way"?
5 ways we’ve improved flakey test debugging
Yes, my 2017 Subaru Impreza has it. However I find it very clunky... the screen is not terribly responsive at all. Not sure if its my phone (an aging iPhone 6), firmware in the head unit that can be fixed, or a poorly engineered hardware in the head unit.
Do you ever feel a little creepy wearing those?

I've seen a few people with them on, and my immediate gut reaction every time is to get out of their eyesight. I'm sure I'm not the only one and it makes me wonder if most spectacles owners even think about it.
HTC teases a standalone Vive VR headset for China
curious, how old are you?
In case anyone else was wondering, the longest line of sight from Mt. Davidson, the tallest hill in San Francisco, is 148.9km, looking southeast over the length of the bay. Here's a panorama:

http://www.udeuschle.selfhost.pro/panoramas/panqueryfull.asp...
Simple and neat. :)
That's a really thoughtful answer. Thanks!
I suspect Adobe isn't interested in committing man hours to that process.
Seeing that your name is green, "Modalert" made me think of some app or something that alerts mods when something needs attention.
>I don't have time for any of the hobbies I had in college

>but that just seemed to make me more tired.

>I'd be a pretty poor parent if I came home with this level of energy every day.

This isn't energy, it's depression. Even if you are not talking about "burn out", talking about your energy levels is a mood issue, unless you are overweight, have a bad diet, or have irregular sleep (which, as you say, you do not).

I would mention these concerns to your doctor. 10% of US adults (http://www.healthline.com/health/depression/statistics) suffer from depression, and it has nothing to do with whether you enjoy your job. The difference, if treated, is that you will enjoy your job and have energy at the end of the day.
Edge is also behind webviews in UWP apps, also WWAHost [0] apps and Store-delivered PWAs [1] will run in Edge

[0]: https://blogs.windows.com/buildingapps/2015/07/06/project-we...

[1]: https://developer.microsoft.com/en-us/windows/projects/event...
Dan Tepfer's Player Piano Is His Composing Partner
I already updated my phone. Is the iOS update that patches this available over a cell network? If not, as is usually the case, isn't that Not Good?
Google's researchers: 95% traced ransoms were cashed out via BTC-E
Well, I don't see how Windows 10S helps push adoption of UWP since you can already distribute Windows Forms, WPF, or Win32 desktop apps on the Store today. At that point, why bother making a UWP app?

Also, Edge only have a handful of extensions. If they want to compete against Chrome, they have to do something about that, otherwise people will just use Chromebooks.
For each trillion dollars of company, you'll need a billion people to pay $1k each.

I'm not sure current demographics allows for more than one such company in any given sector, and it would need to have a virtual monopoly on whatever it were selling.
IPv6 on your home LAN lets you to connect to IPv6 addresses on the Internet. Otherwise, they return ENETUNREACH.
Command line interface to Google translator
It seems to be a philosophical position more than anything:

http://wasdarwinwrong.com/korthof97.htm

I would guess it is wrong; we are on a track where genetic manipulation to treat blatant defects will (relatively shortly) be cheaper than the traditional medical treatments.
While I understand that the use of the term 'mathematical limit' is meant to imply a stable equilibrium, in this context it does make it sound as if there are rigorous mathematical proofs that these unmentioned things are indeed inevitable. I'm not sure if that's what you meant to convey.
Reaching for the Stars, Breakthrough Sends Smallest-Ever Satellites into Orbit
I think he meant "proof of crypto ownership" and not "cryptographic proof of ownership". So probably a screenshot of your balance on an exchange.
I really liked instant too, except I just liked it for the keyboard shortcuts. After submitting a query, I could press <tab> then use the up/down arrows to select, then <cmd>+<enter> to open the links in a new tab.

Does anyone know of Google search keyboard shortcuts even without instant?
Win 10S can run desktop apps that have been "converted" using the Desktop App Converter (nee Centennial) and uploaded to the Store. This is how iTunes will be coming to the Store later this year.

Currently the only device shipping with 10S is the Surface Laptop, and it can be upgraded to regular Windows 10 Pro for free for the rest of the year.
I suspect that step 1 of the Surface Laptop setup experience for users-in-the-know will be to do this upgrade, just like "uninstall craplets" has been for previous Windows laptops.
What is Braille SmartWatch Know all the Features in 2 minute
Unless you're a farmer in a developing country.
You sure? At Google, network storage has been faster and more reliable than local disks, for years. See bradfitz' talks about the dl.google.com rewrite.
Really awesome. Will definitely be usefull for a project I am working on.

Any plan to support other languages beside JS?
K2 incorrectly listed as being in New Zealand?
Imagine if we can get cheap AR glasses or contacts out to the world with new batteries. Maybe you can block them all.
If you keep more of your money through a change in tax policy, you are suggesting that the government gave you money? I'd argue that you are keeping what was yours all along.

Being bled less isn't the same as receiving a blood donation.
10.3.3? "This update requires a Wi-Fi network connection to download." Frustrating. I read this update may be 80-100 MB. Apple, please let me use my mobile data as I see fit. (And a security patch is certainly a worthy use!)
which is probably why the site is called "Beyond Horizons"
Since bitcoin is deflationary (max supply) it's technically possible that 0.0001 might be worth something one day.
Most of those games you're referring to are on mobile, and even Android hasn't received a Flash update in 4 years.
The answer depends on how corrupt your local law enforcement is...
>Then the alternative hypothesis is true and the null is false. (Though normally if the tested hypothesis was X > 100, the null would be X ≤ 100.)

Mathematically, yes. Practically, not always.

In many real world effects, we're not 100% accurate on what the null hypothesis is. We may think the existing process suggests a the temperature increase of 1C, and so we set that as the null hypothesis.

But in that problem domain, we may have difficulty being more precise. Suppose that 1C in the existing process came from the mean of measuring a sample of 100, so the current belief is that the expected value of the increase should be 1C. Suppose in reality it is 1.02C. Now we're proposing a new process and claim it is better than the existing one. This time we take a much larger sample, and see the number hovering at 1.02C - we can then claim the new process is better than the existing process and have a p value to demonstrate it.

The math will be correct, and the conclusion will be wrong.
That is very nice. Here from Reykjavík, Iceland, you can see Snæfellsjökull on a clear day (about 118 km away; featured in Jules Vernes’ “Journey to the Center of the Earth”), and it seems very far away indeed. I can only imagine 216, or let alone 500+ km distances.
This isn't an academic paper but at least one academic, John Tooby, has gone on the record as strongly believing that mutations are accumulating in the human population due precisely to this: https://www.edge.org/response-detail/26714.
Let's say you want to take a portion of my income in exchange for career services that has a cost of 1,000 dollars a year for you to provide.

You say "pay me 20% of your 100k job" netting you 19k, I refuse to pay that steep of a fee and counter with "take 10% or nothing" netting you 9k.

I don't believe its fair to say that you have lost 10k if you accept my terms as the alternative is receive nothing. You have increased your revenue by 9 thousand dollars as opposed to earning 0 dollars. The option you proposed is simply not on the table and can't really be considered.
I disagree with the last sentence. Should being in the police be the privilege of the not-so-poor ? This is what it was like in the middle ages.
The problem with not editing the germline, is that that could easily be used to implement a DRM scheme. The recipient of this sort of editing might have a very high chance of only producing disabled or dead offspring, as they themselves would have been, without intervention. They, and their descendants, would have to procure this same treatment in order to procreate.
With both Linux and FreeBSD being open source, I am curious what is it that prevents ZFS from being a first-class, stable component in Linux right now, just as it already is in FreeBSD.
How old would I have to be to make my comment look understandable to you for my age?
Adobe Animate isn't being EOL'ed.
The medical dogma never comes down to do no harm, at least today. The Hippocratic oath is largely symbolic today. The main goal of a physician is to ensure the well being of their patient. This means that they will judge the risks/harm to the benefits and make a judgement, and receive informed consent.

Anyway what’s abhorrent about the blastulation method? Furthermore, I don’t think there is a need to only let those with a large number of recessive deleterious alleles use it. It should be more open to let people edit the genome of the embryo to remove even one or two dominant or recessive deleterious alleles. There’s no reason that if the technology exists, is safe, and is regulated that it should be only used for people with a huge number of genetic defects.

And can’t you just sequence or test one of the cells from the morula stage?
i assume theyre talking about payroll tax
Are colleges still legitimate now that they are debt mills under Bush Jr.?
I miss Asimov's idea that they could act as churches under law and be safe places for intelligent conversation.