skysight-inc/HackerNews huggingface dataset:
You skipped the juiciest part of one of my favorite scenes of that movie. [scared the bejeezus out of me when I was little, I didn't realise for some time it was pure satire and no adult would be expected to understand him].

So I feel obligated to post the full bit (from wikiquote)

>Wonka: [angrily] Wrong, sir! Wrong! Under section 37B of the contract signed by him, it states quite clearly that all offers shall become null and void if - and you can read it for yourself in this photostatic copy - "I, the undersigned, shall forfeit all rights, privileges, and licenses herein and herein contained," et cetera, et cetera... "Fax mentis, incendium gloria cultum," et cetera, et cetera... Memo bis punitor delicatum! It's all there! Black and white, clear as crystal! You stole Fizzy-Lifting Drinks! You bumped into the ceiling, which now has to be washed and sterilized, so you get... NOTHING!!! You lose! GOOD DAY, SIR! [returns to work]
Cutting edge scientific research is expensive. I don't know why people expect advanced medicine to be cheap. Synthesizing or extracting complex proteins, using rare medical radioisotopes, medical scanners based on the most cutting edge engineering and physics... Almost no endeavor besides physics and medicine makes regular use of superconductors, antimatter (for PET scans), etc.
Wow, this seems really amazing. I read some background from your show HN, but does your software mostly make DNA plasmids? How would you go about integrating that into a eukaryote? I think in the article they used a retrovirus. Also, plasmids have a maximum size for proteins, do you have a vector to incorporate larger proteins?
Is it really? Even just extra 10W over a month is just under 7 kWh and might approach a dollar[1]. Spinning 3.5" HDDs from time to time is especially costly and they often spin down when unused for a long time. Load spike might also make CPU freq scale up and consume more power. Same with bandwidth, you'll incur ISP wrath or saturate it (or keep wasting most of that free space), even 80 Mbps[1] is 'just' 36 GB / hour and under 1TB per 24h. And that's without including overhead from Filecoin, TCP/UDP and IP themselves.

It sounds lose-lose-lose situation: keep wasting your space or saturate your bandwidth or waste power on keeping HDDs spinning all the time due to accessing them every few minutes. It may vary with your usage patterns (if these disks are already always spinning and you have REALLY good bandwidth or two separate lines) but still, seems barely worth the effort.

And why couldn't it be optimized in a purpose built machine? Cheap Tibetan hydro and free cooling (altitude), low power CPUs, fast internet, fast switches and routers, 10 gigabit lan, many HDDs and SSDs (dug up from the Western trash piles even, it's not like failing once a month is a big deal). Chinese already have ASIC for bitcoin and this seems easier to make than that.

[1] I have no idea if I'm generous or stingy on USA power prices and network speed.
> * Frequent breakage of extensions when first switching to the more rapid release schedule.

That's why I switched. It broke most of my extensions every time it upgraded. After the 3rd or 4th time it wasn't worth dealing with anymore. I switched to Chromium and I don't remember it breaking an extension.
I agree.

Most people don't seem to realize the kind of progress that's been made in recent years with CRISPR etc. These problems are becoming data problems rather than biology/chemistry problems. The public (government) should certainly be funding many teams with small amounts of money ($10,000 to $100,000 say) rather than pouring billions/trillions of dollars into "proven winners" (big pharma) that mainly come up with therapies rather than doing basic research.

Honestly I think the same argument applies to so many areas of the economy: alternative energy, space travel, growing food, and so on. We could be finding so many "cures" for relatively modest investments that our current system has actually become very expensive due to the opportunity cost of not doing so. I've spent most of my life asking what we are all working for and towards but have come to the conclusion that keeping everyone busy is the goal now, not progress.
I'd love to see an ad system with manual review for all ads... and have a review fee when ads are changed/cycled.
code reviews are prone to human errors, even if you have the best engineers.
Building a successful tech startup is easy but extremely unlikely.
All second hand. I dunno how Lexus got to be the only luxury car in Cambodia (I assume some deal involving Japanese loans for bridges/roads e.t.c) but all those cars are second hand. Still very expensive given the average income in Cambodia but anyone who's got the moeny ends up with a second hand lexus suv.
How does one review other users' public favorites?
Low cost Cortex-A9 SBC offers GbE and up to 28K FPGA logic cells
local data can still be viewable if the device is imaged and the content is unencrypted.
One of the more important skills in this craft is the combination of intuition and knowledge to know when you don't know something well enough to achieve the goal. The difference between "ambition" and "hubris" is small but critical.
Also if people ever stop using the service your files could be gone forever.
"Most humans are dumb..."

Most humans are desperate. I prefer to view things that way, as it casts less summary judgment on the victims of Paltrow's fraud. Because that's what this certainly smells like: fraud, perpetrated by Goop, and at the very least abetted by Gwyneth Paltrow, in willing exploitation of women's hopes and dreams.

We can all buy into bullshit under the right circumstances. Even the smart ones among us fall for scams, schemes, and snake oil. Whether we're down on our luck, insecure, or even just bored, we're all vulnerable from time to time. That's when bullshit smells its sweetest.

When a predatory person or entity preys on people in those circumstances, the law mostly blames the predator. So should we.
https://github.com/paritytech/parity

About Parity

Parity's goal is to be the fastest, lightest, and most secure Ethereum client. We are developing Parity using the sophisticated and cutting-edge Rust programming language. Parity is licensed under the GPLv3, and can be used for all your Ethereum needs.

Parity comes with a built-in wallet.

How is this not a third-party wallet? They say right on the page that they're trying to be the best implementation of Ethereum. That means they're not the core implementation, right?
I started running these places to get an internship program I was in un-cancelled. When I ditched being an engineer to do nonprofit work I started another to make up the income gap but it was pretty casual. I met the OP and the 3rd person there. Together we decided to start running these places at scale to give us an infinite runway to bootstrap companies.

The three of us talked and we're open to somebody managing the place. We have done house head training when it is needed to open a location, but we like to have somebody experienced shadow them for a few months before going solo. The timelines are pretty tough for this house though. This is why we were going to sell the company for the location the three of us live in.

All of that said, if you're interested in having this conversation, we are willing to have it.
True, but that kind of dehumanization doesn't help anything, and I don't think it's a very good explanation of the problem.
You mean magnet links?
I would argue the Bitcoin author being secret has created more intrigue and possibly more noterriery. It is believed to be Nick Szabo, btw.

There is also a security issue as thought that he has a lot of bitcoins hidden away.
Yes! I'll be adding a way to apply images to PDFs soon. Do you usually have an image of your signature handy on your computer or would you create one if the image feature was available? Another thought I had was maybe adding a "signature pad" where users can scribble their signature and I'd save it for them to use repeatedly. I'd love your thoughts on this.
Right, so I guess I was asking: If you cash out everything as quickly as possible, no one from the government will ask where your millions came from?
"Adapt", "modify", "tweak", "personalise", ...?

Is forking really good for recipes, do you want to automate inclusion of upstream changes, surely not?
> Chargebacks are a blessing when you need them and a curse when you receive them, but something that the economy has deemed a necessary evil mostly because there are a lot of fraudsters in the world

This is an excellent point, and I think it's an example of how an institutional mechanism evolved to help address fraud.

There's absolutely no reason to think chargebacks would not come to exist if commerce were dominated by ETH or BTC transactions.

The difference is that the infrastructure to do chargebacks, merchant account underwriting, etc., can be built very easily with relatively few lines of code.
That's not how JavaScript works. Variable declarations are hoisted to the start of the enclosing function scope and only undeclared variables are global by default.

But yes it seems pretty asinine to use global by default for (not so) smart contracts.
What kind of bias do you need to get 10% Ivy Leaguers, given that they make up like 0.01% of the population?

Not a defense so much as an admission that the parent comment is correct.
I'm just amazed that people want to cut the courts out of jurisdiction over contracts. The courts are a legal recourse if you get screwed.

Why give up those rights and let a computer program (or rather, it's creators) dictate that you're screwed if you make a mistake? I mean, contract law exists because that kind of strict arrangement proved unsatisfactory in real life in the past.
Especially for this; it should be enterprise, bank-tier code, covered by as much red tape as possible.

The problem with cryptocurrency is that they try to be better than the system, but have to relearn all the lessons the hard way. It probably won't take too long before all of it becomes exactly like what banks are now - heavily regulated, etc.
I've never been to a festival that wasn't a mix of neon strippers and crusty dreadheads leaving all manner of chip wrappers and plastic cups on an increasingly sticky ground.

Now, granted, lots of great music and good times, but the whole "lot of people doing drugs for long periods makes a mess" feels... very accurate.
But there is nothing new about cheap small under-powered cars. [We've had them since 1950s](https://en.wikipedia.org/wiki/Trabant).
Why is it being attached to an import/export and bank bill? How are those related at all to an anti-boycott act?
Nice turn of phrase! Good writing deserves an upvote...:)
True. However, it can be against your interests, but you should always consider: what if someone else does this.
I agree IDL is a poor tool. However, it is used widely across universities and research laboratories for space science and earths science and this is not problem exclusive to NASA. Yes, many people use Python, R, or Julia (we use Python in our lab at NASA) but there are people in science who get stuck in their old ways.

That said, this article reads like he's from a software engineering branch, not a science group.
> The usually cited figure is 10%.

Right. And even that 10% is very optimistic. It's closer to 5% or 7% at the most.

> This number suggests that a startling 93% of the companies that get accepted by Y Combinator eventually fail.

Source: [2013] "DEAR ENTREPRENEURS: Here's How Bad Your Odds Of Success Are" => http://www.businessinsider.com/startup-odds-of-success-2013-...
Providing more flexibilty with deleting documents is on my roadmap but I can't get to it today. If there's a sensitive document you want deleted now, please reach out to me at mariusz [at] pdfotter [dot] com and I'll manually delete it.
Do you remember when you had to use iTunes to update iOS? Being able to update over wifi was huge...
The United States alone holds over 45 percent of the global pharmaceutical market [1]. And less then 5 percent of earths population. Welcome to the society of pharmaceutical addiction.

[1] https://www.statista.com/topics/1719/pharmaceutical-industry...
>You're saying you could declare "I now have $30 million in assets" on your IRS forms and it wouldn't trip any alarms?

Technically, it's illegal for the IRS to do so without third parties coming to them or suspicions of terrorism. In practice, they probably rat people out to LE agencies regularly.
Okay, that makes FB and the publishers more money, but how does it solve FB's fake news problem? Or does it exacerbate it?
The article you linked is way, way out of the mainstream on the topic.

That's fine and all but turning around and accusing the conventional wisdom of 'lacking a deep understanding' is a bit much.
It also doesn't address that many of those apps have local caches of data that would fall under the rules.
On a similar note, recently a lot of research has looked at the extent to which utility functions fail to explore a space, and how the introduction of novelty is a crucial new strategy:

"Novelty search is a recent algorithm geared toward exploring search spaces without regard to objectives. When the presence of constraints divides a search space into feasible space and infeasible space, interesting implications arise regarding how novelty search explores such spaces. "

http://ieeexplore.ieee.org/document/7061317/?reload=true
Google bans BitTorrent clients
The software 'compiles' down to DNA - which can be produced and delivered in any form useful to clients. Most of the time that deliverable is a plasmid.

The plasmid DNA is then used as a reagent to manufacture the physical retroviruses that are used to transduce the extracted T-cells which are then reimplanted into a patient.

Practically, multiple plasmids, each containing a single component of a synthetic retrovirus are given to 'viral manufacturing cells', and the output is pool of virus that is infectious only once, and has DNA that encodes the CAR design as its payload. That virus is then given to the extracted T-cells, where it infects them with the viral payload and integrates its genetic payload into their genomes. Once integrated, the cells are tested to ensure they are not further infectious, then reimplated - newly 'upgraded' with DNA that encodes a synthetic CAR protein that is now capable of homing in and killing the target cancer.

Getting all that payload into a plasmid is certainly an art. A lentiviral capsid has a physical pressure capacity such that it can hold <13kb of DNA. This is precisely why it's so important to have good ways of testing/pruning/evaluating new protein designs so that you can prune down a theoretical design into precisely the minimal design required for effect.
If there is a licensing problem with AXI, would Wishbone be a viable alternative [1]?

[1] https://en.wikipedia.org/wiki/Wishbone_(computer_bus)
> files could be broken up into shards and distributed across multiple nodes

You can setup any old distributed database to do this... If there was a benefit to breaking down a file rather than replicating it, AWS would be using this efficiency to provide a better service.

> the effect that a commoditized pricing system would have on the costs of a distributed storage solution

It'll always be cheaper for someone to sell their hard drive than to sell access to their hard drive, just like it is cheaper to buy bitcoin instead of mining it.

Here is why: let's say Alice is profit-driven and greedy and is making $1 profit for 1gb of space. She can use those profits to buy more hardware, make more profit, buy more hardware, and so on and so forth until she has 100,000gb of space being offered. At that point, because of economies of scale, it will cost Alice less to maintain 100,000gb then the total cost of 100,000 people hosting 1gb each (eg. reduce total electricity cost because of bulk purchase).

Now, Alice can grow her operation so big (say, 100 petabytes) that it actually becomes no longer profitable for Bob to host 1gb. Alice has so much lower costs per gb that she was able to drive the price per gb down to a point where the price is lower than Bob's costs.

This is basic economy of scale so far, right? And it's the same reason why data centers filled with ASICs make it useless for you to mine Bitcoin on your laptop.

OK now that Alice is hosting say 100petabytes and has priced out all the individuals on the network, she will be subject to data policy rules and will have to obey law enforcement to kick out users that are using her hard drives for illegal activity.

Alice is now AWS.
And even that undeclared-are-global thing is gone in modern js. It's explicitly an error in strict mode.
FWIW, I've only had a pretty basic intro to math meta-theory, and I think my most "advanced" course in that direction was about Point Set Topology (+ some discrete math courses, but that's par for the CS course).

If one is a mathematician, I think it's entirely reasonable to just "trust" your basic axioms of your "sub-field", but OTOH I can really understand the worry that the rug is going to get pulled out from under you... which is a pretty remote worry given the complexity of math nowadays.

Anyway, thank you for taking the time for that response.
@pg has the right to try and define things however he wants, but he isn't the final arbiter of meanings of words in the English language. I see no reason to suggest that a company isn't a "startup" just because they aren't pursuing "double digit growth every month". There are plenty of ways to get big, and "slow and steady" is still one.

It's also important to realize that a company's growth rate will vary at times throughout its lifetime. You might start out as completely self-funded, bootstrapping, and work very slowly for some period of time, only to reach a certain point and say "OK, now its time to turn on the afterburners and go seek VC / PE money". And as a company matures (hello, Microsoft, IBM, CA, HP, etc.) its pretty close to inevitable that the growth rate will slow down.

The important thing is just to do what makes sense for where you are and what your goals are.
This is the design of most high-level scripting languages (e.g. Javascript, PHP, Python, Ruby)...
If your adversary is the Mossad, or some equivalent thereof, they are going to do Mossad things to you, and you're going to die and there's nothing that you can do about it.

That's a bit hyperbolic. An institution like the Mossad has literally thousands if not millions of "adversaries". They don't kill all of them. They probably kill less than 1% of them.

There's plenty of downside to killing someone. E.g. in 2010 the Mossad horribly botched an assassination: http://www.dailymail.co.uk/news/article-1261435/How-Mossad-b...

If even 1% of their assassinations went that badly, the PR fallout would be devastating. I'm sure they're quite selective over who is "going to die".

Call me a stoic or a fatalist or an idiot, but this is not something I'm concerned about when I'm crossing a border.

There's a 100x greater chance, or maybe a 1,000,000x greater chance that the Mossad (or equivalent) compromise your phone than decide to kill you.
Was airbnb a month away from being evicted or a month away from asking their parents for another deposit?

Lots of rich kids play at being poor all the while knowing they can call home at any point.
I think I finally see where I went wrong:

Instead of actually getting myself well and trying to figure out how to share info on that, I should have just become a celebrity movie star first. Then I could be raking in the dough instead of being poor and ignored and occasionally pissed on for the assumption that what I am doing is anything like this.
Could the answer be to save extra money on the body work and provide less safety for the passengers? I'm wondering if it is like US football compared to rugby. In football the players have so much padding, they run into each other much harder, as they've got protection. In rugby, the players are much more tactical in how they intercept the opposing team.
If we dump everything we might JOIN on to a single document then in many cases we're going to end up with a ridiculously nested document, and/or duplicate data everywhere. Let's try mapping out the project I'm working on right now.

We've got moves, and each move has multiple stops:

move: {
shipper: string,
consignee: string,
stops: [{
address: string,
appt: datetime,
}]
}

So far this looks great. I like this. Yay MongoDB!

But I need to add a driver to each stop... Where do I put the driver? If I put him under the stop I'm going to duplicate his data all over the place. Do I put the move under the driver instead?

driver: {
name: string,
id: string,
moves: [{
shipper: string,
consignee: string,
stops: [{
address: string,
appt: datetime,
}]
}

Ok, not bad. We've got an array of objects under an array of objects but I'm still perfectly comfortable.

Now I need to get a terminal-based look at all the drivers, so I know what every driver is doing in a particular city, also drivers can actually have multiple trucks too:

terminal: {
city: string,
drivers: [{
name: string,
id: string,
truck: [{
plate: string,
moves: [{
shipper: string,
consignee: string,
stops: [{
address: string,
appt: datetime,
}]
}]
}]
}]
}

That's getting a touch nested but... Drivers actually work for vendors, and vendors might work across multiple terminals. Do we duplicate the vendor across terminals, or the terminal across vendors? Also even the driver/truck relationship is many-to-many... Do we duplicate the truck info? What happens when we need to update a truck? Do we attempt to update across all drivers? Do we duplicate that data too?

terminal: {
city: string,
vendor: [{ // many-to-many! duplicate vendor data?
id: string,
drivers: [{
name: string,
id: string,
truck: [{ // many-to-many! duplicate truck data?
plate: string,
moves: [{
shipper: string,
consignee: string,
stops: [{
address: string,
appt: datetime,
}]
}]
}]
}]
}]
}

Ok, this schema is starting to look like shit and it's only going to get worse. The shipper and consignee should actually be unique objects as well, and we might want to update the contact info on them. Do we duplicate that data and update across all moves?

Also we want to cross-reference the shipper, consignee, billing, and ordering entities for market analysis (the consignee isn't always the customer, and the customer doesn't even always get the bill!) Do we duplicate that information across moves? Do we duplicate moves across entities? More many-to-many relationships...

Maybe I'm just not creative enough to use MongoDB, but I'm really starting to feel like this is a square peg in a round hole.
Productivity on the go
I am curious. How was the cancer found? Did you have any symptoms?

How was the treatment?
The legal mumbo-jumbo of written contract is also incomprehensible to lay people..
No, being Turing complete makes it impossible to be 100% secure and trustworthy, by definition.

It is possible to have trusted contracts, iff their logic is (mathematically) proven. But the VM can't make contracts more secure by itself.
THE WINNERS OF THE 2017 DOG PHOTOGRAPHER
I'm not asking if you're an Android dev to disparage you, I'm asking because the two features are outwardly very similar, but have internal differences. And you can use one to get a result that looks similar, but is not the same, as the other.
You are aware that aol continues to exist, right? They had 15 years to implement agile. Some groups did. It wasn't widespread though.
Sure. One can imagine a 64-bit 24 core RISC-V CPU with 60 billion transistors, all backdoored by some management processor. Perhaps by then the management CPU will be an x86 core running Linux.

:)
If you rent it for a few thousand a day, it's easily profitable.
It’s a lot more subtle than that. Under certain (very) edge cases, there may be an issue.