skysight-inc/HackerNews huggingface dataset:
You didn't make it, but you hear far too often that drugs for management of chronic conditions are more profitable than cures for acute conditions, and that's what determines what goes into the development pipeline.

The truth is more complex than that. The reason that you don't see investment in antibiotics is that the low-hanging fruit is picked and you cannot use the new compounds unless as a treatment of last resort, and sales would be far too low to be profitable. They will be needed, though, in the medium term. The financing model in pharma is broken and there is no change on the horizon in that department.
>Getting feet on the street is probably one of the most impactful things a city can do.

This is a very naive comment. Most people dont no want to walk 1 mile, let alone 2 or 3. Walking 1 mile takes almost 30 to 45 minutes.

If the weather is PERFECT people are happy to walk a few blocks. But outside of that most people do not want to engage in serious walking.

Many cities are not walk friendly due to their temps in summer or winter or both. Walking in 100 degree or 30 degree temp is very not fun.

Walking serious distance CONSISTENTLY is also kind of rough on your feet, knees and hips.

Bicycle friendliness is way better. Bikes are very cheap (the bike I ride full time cost $125) and even people with very low levels of fitness can easily bike 1 or 2 miles. 1 mile on a bike takes about 15 minutes or so.

Cycling is very easy on the body and one can move a decent amount of goods/weight with relative ease.

If you bike in 100 degree temps (I have for years) riding gives you a breeze. You dont realize how hot it is until you come to a stop. If you bike in 30 degree temps (I have for years) riding will warm you up.

source : Have ridden and walked full time for 5+ years

My grocery store round trip is 2.2 miles and Ive made that walk hundreds of times carrying groceries. The walk adds about 40+ minutes of time to the grocery store visit. It takes considerable effort and fitness and is not for the meek. The same trip on a bike is much faster and much easier.
This is a personal decision but I can say this about your doctorate, universities are not going anywhere. If having a doctorate is important to you, you can do it now or you can do it later. I was just over 40 when I started mine and 43 when I completed my studies and defended my dissertation. If you want it bad enough you will do it.

The girlfriend and missing your family is another matter altogether.
I think it's something that should be sort of pushed by folks who are upstream. As long as people can continue to use dangerous protocols without friction, they'll keep doing it.

I think it has value for users to say, "Oh, so I need to go install a package in order to continue using this protocol." Maybe that'll trigger a change on the server-side.
No, when Google just lists local businesses and puts them on a map, that's NOT ads. Businesses get listed at no charge.
I think you should read the rest of this conversation thread. Some population groups are surviving hybrids but the percentage is very small (my own Neanderthal percentage is just 2.4%, so I'm actually almost more Jewish than Neanderthal), not evenly distributed (Asian is much less AFAIK, it's mostly a European thing), and even in the ones which are, the percentage of hybridization is decreasing steeply over time; and yes, all the Neanderthals are gone, which doesn't speak well for their fitness.
Lets try not to incite language flame wars in a discussion that could be super helpful without it.
Show HN: Light Diffraction – A light wave interference simulator
This behaviour is encouraged by Chrome. The address bar prefers to suggest searches over the user's own history, ensuring that even a website they visit every other day will likely trigger a Google search. Firefox, on the other hand, has a strong bias towards history, allowing the user to go straight to their destination.
> Not true, WebRTC was designed to address this and is already supported in all major browsers.

False, you cannot build decentralized p2p networks on webrtc because you always need a signalling server. the session establishment protocol needs one-time tokens which need to be exchange some way, which means you can't build a self-sustaining network.

For example Kademlia DHTs require the ability to quickly send requests to peers you have not contacted before (that's why it's UDP-based). If that requires a session setup and teardown every time that negates the advantages of iterative lookups, even if you could decentralize that part.

> Not really, creative DRM is common in desktop applications.

None of the ones I'm using on a daily basis have DRM.

> Not true with new web APIs that expose traditionally native functionality like Bluetooth and the FileSystem.

My understanding is that the FileSystem API is an emulation of a filesystem that stores things in a database in the browser profile. That's not interoperability with native. IPC, file access and sockets are some cuicial features for interoperability.

> Lots of web apps are being built for offline usage with new offline-oriented web APIs. Web apps can also be packaged as offline Chrome Apps or "native" apps with Electron.

aiui chrome apps are dead except on chromebooks. those offline-apis (service workers) don't give you portability, depend on the browser cache and so on. that gives them volatility.
And Electron... well, that just makes it another desktop framework which does provide interoperability with native, I guess I'm kinda ok with that case. But you don't really need wasm then, you can just link to existing libraries. A bit of a pity though that mozilla canceled its positron implementation, would have been nice having two implementations.

But that's besides the point. As I said previously, it's not about the best possible outcome you can achieve with the technology, it's how it will be applied to the masses. And that's where I think it will be used as a tool to move more users into walled gardens.
That's an interesting choice; I'm not sure it's a good one. While I don't want anyone using the old r protocols, I also don't really want transparent redirects to other protocols. What if a Debian user was in the habit of using "rcp file somehost" and found themselves working on a non-Debian system where rcp was not linked to a secure command?
Only if the choice between PPI and H2 blockers is random. If there's some self-selection going on, there isn't much to say about PPI's impact on patient health given what we know about H2.
Sure, but a despicable company may still have legitimate complaints about other companies.
I used to do this with Twitter, but that's impossible these days.
Anecdotally, I do a lot of exercise and for a year I'd always wake up with a sore back (top of hips, either side of spine), or after sitting down. Physio eventually told me my hip flexors were really tight and that was the cause of the referred pain. 4 days of long stretches on those a couple of times a day and I'm good as! Crazy I went for a year with it irritating. If it helps someone, glad it did. Something like this (first result on google) http://www.stack.com/a/4-hip-flexor-stretches-to-relieve-tig...
What? How could it predate telnet? That was RFC 15 from freakin' 1969 and before that, there isn't really anything. But even if you consider RFC 854 to be telnet, well that's https://tools.ietf.org/html/rfc854 May 1983, rlogin was released in 4.2BSD, that's July 1983 http://www.informatica.co.cr/bsd/research/acrobat/830721.pdf
And in chrome the address bar is hijacked to be a Google search
The r-cmds still have a place within cluster environments where their use is protected from the outside world and the overhead of encryption could adversely impact performance. Given the high percentage of Linux systems on the Top 500 list that's not going to change anytime soon.
Did you try a physical therapist? I had knee pain from rock climbing, and the usual "treatment" in this sport is just to rest and heal, but after 4 months I had no improvement. I had little faith in PT because I was convinced I had some kind of tear, or maybe a bone spur, etc.

Anyway, the physical therapist put me through motions and he showed me on the skeleton how it was actually supporting muscles that were much weaker on one side of my body. He gave me basic exercises to do every day to strengthen those muscles, and in the end it worked beautifully. No more knee issues.

I'm glad you found something that worked, but I'm also curious if you tried out PT, and what they told you?
"but" is not appropriate. You aren't contradicting anything I said. I'd agree with you completely, but your points are only "and" from my post, not "but".
This is purely speculation, but judging by how gun-ho they were about OPEC production cuts, they may have much less oil than widely believed. It could be they would have needed to cut production anyway since the wells are aging, and they're just making the best of it.
Free online income-daily $1+ for doing easy task
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Strong SSL Security on Nginx – Raymii.org
very edge case, but you can't network-install an SGI machine without an rlogind on the other end.
What are you basing this claim on?
Previous discussion: https://news.ycombinator.com/item?id=14688616
This isn't just collecting as investing. Many players collect not to be collectors but because they just get obsessed with wanting to have certain instruments that they hope to (and in some cases actually do) play.
Do its arithmetic operations use some sort of polish notation or am I missing something clever here?
Yeah, a log/log plot of incidence of cancer against age shows that about 6 mutations are needed in a cell to result in cancer. A decent cancer needs invasiveness, metastases, vascularization and evasion of the immune system. The last two are especially important and that's where current research is directed.
There are like 100+ cancers and likely not all genes affect all cancers.
A biometric ring could replace your passwords, cards and keys
Inside the Manipulative World of Film Color Correction (2015)
The ability to walk without falling over takes a lot of computation, even if it seems effortless.
Any fellow reservation holders have an idea of when to start expecting our units to roll out? I'm told the #'s are not sequential and correspond to regions instead...
I'm on a 3 month back pain streak which is unprecedented for me. It's co-occuring with higher than usual weight range for me, as well as I had started making a concerted effort to stand straighter and adjust head-forward posture and I think that might also have triggered something. I can't tell for the life of me if it's arthritis or some kind of over-tensioned muscle. But in regard to the article, I have no hope in the medical industry to help. Damn sad really.
Honest question, how is it skewed? Not a fan of google news myself for other reasons but never felt they forced a PoV.
The car transmits 10 times a second to assist other vehicles, signals or traffic management systems.

The notion that big brother is going to track you in tenth if a second increments is not a thing.
I've been on them for about 10 years, for the last few years I've halved the dosage. I might have to talk to the bonesaw about halving it again with the intention of getting off them.

my experience though is that if I stop taking them I get it pretty bad and my energy levels go right out the window. I just become sloth like all day every day and cant think worth a damn.
one more thing to mention about that default chrome on android: you cannot install ad-blocker there.

you may install firefox and still will have a lot of time links opened in built-in chrome, on android
That's neat! If you redundantly add an extra vertex (in its own component) whenever you glue, then you actually get h(x) = f(x)g(x). I wonder if there's some natural way of defining a multiplication of connected graphs so that you get equality on the nose?
Matrix is my one of favorite film.
Think we need to distinguish between math as "performing pre-defined calculations rapidly", and math as "figuring out solutions to problems, often novel, sometimes new, that have a mathematical underpining and an ability to be represented in mathematical terms."

In short, computers are good at rapidly performing the calculations of a solved problem, or implementation of the algorithm. Humans are good at coming up with the algorithm. A good, general purpose algorithm generator is probably ai-complete, although i could see "evolution" as a plausible answer to such an algorithm generator too, though maybe only in its capacity to generate beter generators. Or maybe I'm talking out my excretorial orifice, I'm often not sure.
I spent so long looking for a font that rendered on Windows like Monaco 10 did on Mac that I wound up just making it myself, with a few changes. I called it Monocle and I still use it.

https://fontstruct.com/fontstructions/show/517659/monoclefix...
Nice! That file manager looks awesome!
I have run into a few situations where rlogin and rsh are still being used, but none of the reasons were due to performance vs ssh. 9/10 is due to having to run down all of the processes, scripts, etc that call out to these. It is mostly as easy as symlink to the secure counterpart.
It can be illegal to use your market dominance in one area (search) to reinforce or create market dominance in other areas.

As far as I know it's only illegal when there is harm to consumers. Antitrust laws are meant to protect consumers, not competitors.
>With no Constitution, slavery might have persisted for much longer.

There is experimental data here; France, from 1315 has prohibited slavery in mainland France, and moreover any slave setting foot on the soil of mainland France would be instantly freed, at least in the eyes of French law, from then on, and at the time, France was an absolute monarchy. The UK eliminated slavery in 1833, long before the US did, and they don't have a proper constitution to this day.

The fact that we were one of the last developed countries to eliminate slavery shows that our constitution did not hurry the day that slavery would be eliminated.
How is the guy an idiot if it's been working fine for twenty years?
It seems to be fairly mature for something I've just heard of. It's crazy how many languages we have now. It's mostly a good thing, but I always wonder how nice it would be to have these immensely talented designers focusing on libraries for existing languages...etc. What is ballerina's performance? I assume it is alright being on the JVM?
Our attempts at trying to capture the Chinese market and the result of it
wow, looks like biometric ring has so many smart feature.
There is some reverse-engineered documentation here:

https://github.com/AntonioND/gbcam-rev-engineer/tree/master/...

The ADC appears to be part of the ASIC which contains most of the circuitry to interface the sensor to the GB.
> > "Every one of these graphs has a unique chromatic polynomial"

> This is incorrect. Two different graphs may have the same chromatic polynomial. For example, all trees of N vertices have the same chromatic polynomial: x(x-1)^(N-1)

As soverytired (https://news.ycombinator.com/item?id=14697626) points out, you're refuting the claim that the graphs have distinct chromatic polynomials. To say that a graph has a unique chromatic polynomial means that it has only one, not that no other graph has the same one. (For example, (almost?) everyone has a unique biological mother.)
I can personally vouch for push-ups as a cure for back pain. When done in proper form, push-ups are one of the best exercises even for the spine and back. The risk of injury is fairly less. I usually do 3 sets of 6 to 8 push-ups every morning. The plank is also a good exercise. I can't hold the plank position for more than 30 seconds though.
SSLv2 has been created by Netscape in 1995 and SSLv3 by the same company in 1996. From the start, SSLv2 showed weaknesses and has quickly been replaced by SSLv3. TLS is now, and since several years, the standard.

Those protocols, too often used, are vulnerable to Man In The Middle (MITM) attacks allowing a third part to intercept, modify and decypher transferred data.
I believe Online Education is the future of knowledge distribution. Yes, I admit that it lacks social gatherings among the beings sharing the same competitive-cum-curious motive to graduate. However, I see in the future with the tech innovations like Virtual Reality, Improved Compression & Broadcasting on the Web, one can have access to the top-notch contents on the desired subject once he/she accumulates enough motivation & stays focused on the curriculum regardless of the duration he/she takes to complete it. So, yes I feel positive towards the future of education although it might face numerous criticism..those who will stay determined to exercise the contents the web has to offer, will definitely overcome the cons of e-learning.
To clarify the term: "a2g" = "ass to grass", or full extension at the bottom of the movement such that calves and hamstrings meet.
> while Jefferson took his secret to his grave

James T. Callender reported on the Jefferson-Hemmings affair.
Timing. Where do you think G slots in the timeline, relative to the Latin classics?
Useless Ethereum Token ICO raises over $5,000 in the first twelve hours
I built a service last year that provided a SQL database over CORS, access control (user login, registration with email confirmation, and password reset via email). Security was over https and user controlled authentication tokens. The idea was to provide toolkit for building dynamic services for static sites. The archetypical use case was comments for static blogs. I built a simple forum that supported user signup, posting topics etc... as a single page app. Excercised the whole thing.

I had some interest but acquired no regular users. Email me if you'd like more info, I'll not promote it here.
You found what causes a lot of chronic pain - muscle strength imbalances. Many times the pain and the imbalance are not intuitive, but a PT can give simple exercises to fix the imbalance and the pain goes away.

Posture can also be helped with muscle strengthening. Years ago a PT gave me a ton of exercises to combat sitting at a desk all day. I still do them at the end of my usual workouts.
It's really language version pinning for source code.

Rust uses version pinning heavily. This gradually builds up a legacy code problem, as old versions never really go away. A recent article on HN pointed to some bloated non-Rust phone app which shipped with four different versions of some libraries.

How does this work when crates with different epochs are mixed? The business with "core Rust" suggests that all code must be compiled with the same core compiler, because the run-time model might change, but some crates may have different epochs.
The HN community is interesting in that respect and it's not only with some medical issues. As an example, any article on pesticides and modern food production will be full of comments decrying them and claiming health/taste benefits from alternatives. As you say, the community is surprisingly unscientific. Maybe that shouldn't be surprising because most people here probably have a technical and not scientific background and by virtue of having a reasonable disposable income are also the target demographic for products based on alternative science.
Surely,Putin is a powerful man.
What an incredible answer. I love posts like that.
Yeah, that was posted elsewhere in the thread. I thought of it as a name specific to Usenet, as Network Decay is specific to television networks. I was hoping for a general term.
> While it's healthy to be skeptical, it's also healthy to be skeptical of the skeptics.

Well said. Skepticism is important, but it's not an unerring guide to truth.
It's about fucking time.
Seems like you can easily expand that argument to say that all plants, animals, and even natural processes like crystal formation are good at math.
Ask HN: When do you start thinking about performance in new projects?
5-10% is 3-6 months of Moore's Law.
High speed, low-latency, interconnection in clusters is not done via rcp or scp. Also, encryption has lower performance impact than some would assume.

Nonetheless, even if there is a cluster environment using these old commands for some perceived performance improvement, they're certainly running a bunch of custom software; it's not gonna be a stock OS install. So, there's not gonna be any harm in having to install an extra package to get the r commands.

Having it there by default to serve some tiny segment isn't really sensible.

I'm not saying eradicate these commands from the face of the earth. I just saying putting them into the default installation of any OS in 2017 is an unnecessary risk.
> How does this work when crates with different epochs are mixed?

It Just Works. (The discussion contains some stuff about macros, which may be a bit more complex, but that's the core concept anyway.)

> the run-time model might change

Rust has no more runtime than C.

It's in fact in the opposite; the only kinds of changes that can be made in epochs are basically to the parser, everything below that has to stay the same. This is for both technical debt reasons as well as for "mental debt" reasons; the core way that Rust works cannot change.
I think the author is somewhat missing the point that the whole Serverless paradigm is not so much about emulating past architectures without servers.

It is more about building completely new kind of architectures, where applications are no longer monolithic Node.js/Ruby/whatever server processes, but consist of tiny decoupled components interconnected by evolving systems like AWS Step Functions.

This development is dependent on the popularity of static websites, powered by application frameworks like React, which relax the speed requirements of separate REST API servers. Some speed is lost, and a lot of productivity is gained, by getting rid of huge amounts of user-space code and long-running processes.
Yeah, think about how complicated it is to play a sport like tennis or frisbee. Running with co-moving objects and players. Integrating the position, velocity, and acceleration of all these things in order to compute a solution. That's some decent undergrad math!
To expand on that point, the brain is not good at simple products of large numbers, but is fantastic at doing things like triangulation. Or calculating how much muscle to contract to keep your balance going into a turn whilst running. Or eyeballing quantities - we notice when we get it wrong, but the vast majority of the time, we're pretty good at getting estimates correct about the human-scale world around us.
It has always annoyed me mightily that people accept this as a foregone conclusion that Thomas Jefferson is the father.

Historians condemned the original report by a lone graduate student which seems to be accepted as an absolute fact. Jefferson had a brother, Randolph, who was always at the plantation when Thomas was there who is documented to have had children with dozens of other slaves. Why wasn't that even considered?

DNA tests only proved that a Jefferson male was the father, not Thomas Jefferson. There were 25 Jefferson males alive at the time who could have been the father. Only Randolph and Thomas were at the plantation every single time that Sally Hemmings got pregnant.

http://www.claremont.org/crb/basicpage/the-case-of-jefferson...
Someone should greasemonkey this ftw
Wonder if the author tried MobX before settling on Cycle.js... It was not mentioned once