skysight-inc/HackerNews huggingface dataset:
The best health advances of all time were developed by passionate, and sometimes uneducated, volunteers -- people who were not working for a profit motive, but for a good-of-all motive. Case in point: the discoverer of penicillin, and the inventor of the vaccine, the inventor of the public blood bank, and on, and on, and on.

Inventing then was (arguably) less costly and technical than it is now, because those were low-hanging fruit. A lot of the low-hanging fruit has probably been discovered by now, though we can't be sure, meaning that future research aims at higher-hanging fruit and so, metaphorically, the would-be inventors need ladders.

These people need help, not profit, because profit isn't what motivates them anyway.

EDIT: Let's not forget public health reform can save more lives than just about anything else (thank you Oliver Wendel Holmes/Ignaz Semmelweis http://www.accessexcellence.org/AE/AEC/CC/hand_background.ph..., Sara Josephine Baker, http://en.wikipedia.org/wiki/Sara_Josephine_Baker and their present day equivalent, Atul Gawande).
I don’t want to get my hopes up, but:

One report[1] even claimed an iOS update as early as Monday might be able to relieve the issue due to a lag in the iPhone 4's ability to switch between frequencies causing the loss in signal.

(Even as most reports seem to indicate a complete disruption of service, rather than a simple “lag”.)

[1] http://www.appleinsider.com/articles/10/06/25/death_grip_hys...
(To be a taken with a grain of salt, as should anything at AppleInsider that is uncorroborated.)
I use a javascript MVC framework called Claypool for structuring my client-side code. It's really good!
http://docs.jquery.com/Plugins/Claypool
He's Upset About the iPhone 4 Antenna
You're clearly in love with the cleverness of the cow. It takes center stage. Meanwhile, it means nothing at all useful to me.

If you can't get over the love of your own cleverness, you are doomed.
He should put the project on kickstarter and let the people speak :) I'd throw in some money, as would every type-1 I know.
I don't like Python, either. There's nothing wrong with disliking Python - there's lot to dislike. There's also a lot to like, for a certain kind of person - e.g. not you and me.

It's an aesthetic and personal choice.
Can you wait for a month?

http://news.ycombinator.org/item?id=1257488
It only works in chrome because of that http://news.ycombinator.com/item?id=1465194
and 26.03% "Microsoft" ?
Isn't there an app for that?

As in... has no-one created an app showing a real-time scrolling graph of reception level and an accurate (or as accurate as possible) number of the current reception level... perhaps with an overlay of the number of visible towers and strength?

Because if they did, then not only could it be proved by the layman but if the problem existed then the layman can visually see the effect and visually gain feedback on their techniques to find a better way to hold the phone.

If this doesn't exist, it sounds like a great cash-in app for right now. I'll take 2.5% of revenue for the idea.
How sure are you in your claim? Any proof that GMail is not written in GWT?
But at least the Exxon CEO got his life back! Wait, wrong decade.
Founder Mastermind Breakfasts, how we do it
That's what I ended up doing, but this was happening with a very large set, right in an inner loop. Luckily this was running in batch mode, so I could go get lunch or something instead of taking the time to make it faster.
Naked Economics by Wheelan

http://www.amazon.com/Naked-Economics-Undressing-Dismal-Scie...
Somehow it seems that the profit motive in pharmaceuticals motivates good science, but targeted at relatively strange things. "Lifestyle" drugs are huge: everyone wants the next Viagra, basically. Perhaps not surprising, because recreational drugs have always been popular, and the "fluff" end of legal pharmaceutical development is the part that sort of bleeds into recreational, since it tends to target something closer to "enhancing" the lives of already fairly healthy people with money, rather than "treating" the ill.
If there are still any left, i would also love one
www.klaustrofobik.org
Get desktop notifications from web applications
As the husband of a Type I, I would gladly donate a portion of my income if it would go directly to finding a cure.
I always get a chuckle when I see this list. Other than literacy and arithmetic, it's like the curriculum from kindergarten to fourth grade.
More common misconceptions are debunked in "Don't Swallow Your Gum!: Myths, Half-Truths, and Outright Lies About Your Body and Health".

http://www.amazon.com/Dont-Swallow-Your-Gum-Half-Truths/dp/0...
Nice first cut. I think I can actually figure out what you do from scanning the homepage, which puts you miles ahead of most startups posting here.

Here's the harshness:

1. The "Advertise Yourself" bullet points all look like buttons but clicking them does nothing. They should either go somewhere, pop something up, or stop looking like buttons.

2. I'm trapped on the first page of "Start Now". I assume I'm supposed to click a theme, which pulls up a lightbox with six balls, stating "Excepteur Sint Occ". Whaa??? Clicking it opens the same thumbnail gallery in a new tab.

That can't possibly be what you intended to happen.
Actually Kate is quite powerful. But he says he uses KWrite, which doesn't even have tabbing/buffer support.

(This photo, btw, could really use some color/brightness auto-balance)
If you want managed, I think Rackspace is still the best. They have gotten us out of plenty of jams. Fastest response times, great monitoring, phone support, etc.
Why play their game? Just ignore them I say.
You might be right that government can not do better than business, but this particular story is an example of where they can.

If there really "are plenty of companies that are not selling insulin, so they would be interested to be able to sell diabetes cure", none of them has come forward. This might be because the chances of developing are not good enough, but it sounds to me like you are starting from an assumption ("private sector would jump on this is if it was a good idea") and working your way backwards ("therefore this cannot have been a good idea").

Personally, my belief is that the best funding approach is multi-polar. In other words, there should be some government funding, some private sector, and some non-profit foundation funding. Each of these funders has blind spots, and is frightened by some research while others embrace it. The combination allows the entrepreneurial scientist to push their research forward at each stage.
I have a great little app for my Android G1 that shows your location on a google map (GPS) as well as the location of the cell tower you're connected to. I suspect Apple don't provide an API for this sort of stuff..
We are running a web service (just the API no front end) written in Python 3 for a tiny bit less than one year.

Even under considerable load, the traditional Apache/mod_wsgi combination never failed (though we had some encoding issues during development).

The reason to go p3 was for one the new string handling, which I personally find absolutely beautiful and the idea of future proofing the application. We are a small shop and certainly don't have the resources to rewrite the thing in 3 years when all the cool stuff is happening in python 3 land.

This was also the reason to start development of another application in PHP5 just when 5.0.0 came out. There it paid off, though with p3 I'm not quite sure. It looks as if we are stuck with 2.x maybe forever.
This is a great explanation. I found it really easy to follow.

The only part I'm having trouble understanding is the cubic graph example. I am aware of the four-color map theorem but I've never seen it expressed mathematically.
For what it's worth, I think that there is actually a market for this. At least, I know that I fall into the category of somebody with a site to advertise online but without the photoshop skills to make a decent banner ad.

If this were simpler and cheaper, and produced comparable results to communicating an idea to a designer and paying him to make me an ad, I'd probably use it.
I learned JavaScript from The Definitive Guide before The Good Parts came out, so maybe my opinion is skewed, but I don't think Good Parts covers enough material to be useful on it's own (Good Parts doesn't cover DOM APIs at all, for example).

I can tell you Definitive Guide also sat next to my desk to serve as a reference for a long time, though most of the same material can be found on https://developer.mozilla.org/en/JavaScript http://www.w3schools.com/js/default.asp and many other websites.
It is entirely sensible not to go ahead with a startup if you're not sure about whether and how it would be a successful business. You'll never know for sure, but it makes sense to have a good idea of whether you have a market, for example, before putting in all the work of building the thing.

Putting out your ideas and getting responses is a good way to start. Start an ASK HN post, explain what you're doing, and put each idea as its own reply to your post. Then people can reply to each idea separately, and you'll get a conversation on that.

Remember: the idea itself isn't always fascinating to hear. Basecamp - project management for teams; Posterous - simple blogging. And so on. So don't worry if your ideas get an "It's been done" response. What matters is whether there is room in the market for you, for your price point, for your feature set, for your marketing strategy, and so on.
This is a great showcase for what's possible! I have slight graphic issues (harsh borders) on my iPad. Anybody experiencing the same?
It was a very interesting read.

On a side note, I want to thank you for all you've done on security for bsd - the OS I primarily use.
I second this rec. The author breaks down economics with common language and regular, everyday topics (no charts, graphs or formulas).
This is correct, C++ does dispatch based of the type of the arguments. That's how also ties in further into how linking and name mangling works.
Yes, exactly: if pharma is good business, and not philanthropy, then they have to focus on the people who will pay the most, the most readily, and the most often. End of story.

Case in point: I'm an American who lives in Vienna, Austria, and I have recurring upper-respiratory/immune system problems.

Here, I am treated with a so-cheap-it's-almost-free immune system booster called Broncho Vaxom. It's nothing but dead bacteria, but it's extremely effective (essentially an oral vaccine).

It's used to save lives of children in the poorest of nations -- but it's not available in the US, because it's not profitable, whereas continuous rounds of antibiotics are.

http://www.google.com/search?q=broncho%20vaxom
Is that 90% of browsers or 90% of users?

I think this kind of thing is like a light on the horizon for web designers. It lets us know that some of the things we wish we could do now are at least going to be feasible someday...
I think the concept is brilliant but in my own opinion you are not highlighting the real value proposition which I believe is:

Post your ad to several advertising network from a single place. (Although you seem to be supporting only Google at the moment)

I would suggest the "free templates" is positioned as an added advantage and not the main value.

Other people have touched on the little visual errors. So I wont repeat that.

Good luck man! and may the dollars roll in.
Need recommendations for a reliable data entry service provider
I concur though for me after updating to 3.6.4 and then updating my flash plugin on my mac mini Firefox wont even open. It crashes each time i try to open it.

Unfortunately after six years Ive moved to chrome. I need a browser that works and is stable. Chrome doesnt crash and i can have 3 tabs open running flash content.
Would you trust lavabit email for non secure messages as an alternative?
I am wondering if you guys would trust a email service like lavabit http://lavabit.com/secure.html

At least for unsecured communications.
I am so anti-crying-sexism it hurts, but your logic and the OP's logic make no sense.

Ask those male kindergarten teachers if they WANTED to stay in the industry, and if so, why did they leave?

I think there are lots of women who leave IT because it's a nasty, brutish and short industry, with less job security/respect than most intellectual professions, where you must constantly work in your off-hours to stay up to date, and where you're likely to be upstaged by a 16-year-old who's willing to sleep under his desk because he has no social life or responsibilities except code.

The theoretical sexism is just the icing on the cake.

That's probably why women are flocking to bio engineering, etc., while dropping CS. It was true in the day of the Microserfs book and still true now: where a degree is a true requirement, you are insulated against 16-year-old upstarts.

I think women, on the whole, are more "reasonable" than men with their pursuits. Whether that's a good thing depends on who you ask, and from what perspective you look at it.

(Oh yeah, and I'm a woman.)
Also: isn't this what SVGs are for? Fast rendering, resolution independence... Drawing stuff with CSS3 is a cool hack, but I don't see the motivation for this from a practical perspective.
I submit that there's more to this story than "pharmaceutical companies weren’t interested in developing the therapy".

The Juvenile Diabetes Research Foundation http://www.jdrf.org/ funded $100 million dollars of research last year alone into research for juvenile diabetes (type I). Link: http://www.jdrf.org/index.cfm?fuseaction=home.viewPage&p... Funding is predominantly from individuals and families searching for a cure for diabetes. That includes people like myself and my family. We could care less what mechanism or what business model cures diabetes.

Of that research, there is significant research into stem cell therapies and cures Link: http://onlineapps.jdfcure.org/AbstractSearchEngine.cfm Select "stem cell therapy" from the drop down.

Lastly, the head of JDRF is a tech star. http://www.jdrf.org/index.cfm?page_id=113971 He founded Citysearch and Overture (the originator of keyword marketing. Bought by Yahoo).

I'm a big JDRF supporter since my sister has Type 1 diabetes. For any of you that are passionate about curing Type 1 diabetes, look into JDRF. Link: http://www.jdrf.org/
I think that's more of a mac issue. I've been on windows/Firefox since 2003 and Flash has never been an issue for me. I can count on one hand the number of times it has crashed my browser in all of that time, which is to far less times than windows itself has crashed.
Isn't this basically a standard principle behind fault tolerant systems design (and languages like Erlang) where you just stuff the system fully of redundancy so you can crash individual parts when they go wrong and recover instantly ?
Gregory Mankiw has published a numerous excellent books.

http://en.wikipedia.org/wiki/N._Gregory_Mankiw
Yes, many countries are better than the US for entrepreneurship. I'm sorry that France is not one of them, but that doesn't really speak for the rest of the world -- your countrymen invented the word 'entrepreneur,' but they also invented 'bureaucracy' and 'laissez-faire'.

In Austria, if you become unemployed, and want to use that as an opportunity to start a company, the govt will extend your unemployment benefits by 6-18 mos, and give you a big break on your social taxes for years.

Also, you get unemployment insurance as a self-employed person, as of a few years ago.

And, naturally, everyone - no matter what they do or how much they earn - is covered by social health insurance, which is excellent. (Also pensions!)

Also, yes, you have to come up with 20-30K euros to start a true LLC -- but you can do business for "free" as a selbständig, or self-employed person, including employing another. However, if you do set up an LLC, you can never be liable for more than that 20-30K euros - it is not a fee, it is an escrow. If you were to close the business, without outstanding liabilities, you would get your money back.

Taxes, liability and healthcare may SEEM like the least of worries for a startup -- right up to the point where they suddenly become life-or-death, mission-critical. Naturally.
I think it's a good reminder that there are some things you believe that are not true.

Some things I believe, some things you believe.

No matter how informed or educated or logical we believe ourselves to be.

It's something to keep in mind.
I'm not a native speaker, so here it goes:

What's up with the raspberries?
You definitely have to read Getting Real by Jason Fried of 37Signals.

By reading this book you'll know every single detail how to direct your idea to reality, at least it happened to me...

http://gettingreal.37signals.com/
Personally I'd recomend a Cherry G83, it's really cheap, lasts ages, and feels great.

Although a generic budget keyboard (about £10-£15 here in the UK) it's become really popular among PC gamers (the sort who wouldn't think twice about spending £90 on a special gaming keyboard), and personally I've used it as my primary keyboard for years, it's never let me down yet.
Great analysis!

I can only add one tidbit:

Whenever someone uses "deep" as a description of tech/knowledge/experience, that is a sign that they are full of it. E.g. "deep technical rocket science."
On nfs?
I am playing with pyjamas currently. It is not working properly with chrome. I am trying to resolve that issue now.
On my 3gs in central SF, the 'bars' indicator is already almost useless... it can show 4 or 5 bars, and I'm still unable to initiate calls, receive calls, or hold a clear call. It's so untrustworthy that in my more paranoid moments I wonder if some prior software update included a 'inflate the bar count' change.

This talk of fixing iPhone4 issues with an OS update makes me wonder the same thing. Maybe they'll just smooth/inflate the bars display.
> so you wouldn't need to go through the intermediate forwarding server to get somewhere.

That would break the domain based security model the Web uses

Flash can do sockets, but it requires crossdomain.xml
Gmail was written using Closure library built by google itself. Google release it for open source community now.
Why should he?

Are you earning more / more successfully than him? No? Then why would you think your advice would be helpful?

You shouldn't conflate "what I like" with "what works."
I believe he's talking about "attach rate" - the magical metric that drives the console hardware industry (i.e., games purchased per console).
He's always been 98% civil, thoughtful and friendly in person. That doesn't mean he won't point out if you or somebody else is being a moron or a dickhead, but he does it judiciously.

Zed, like so many other successful writers (e.g. Mark Twain, Churchill, every famous playwright people quote on their blogs) has made a career out of being a sharp-witted asshole in print.
Open Calais is already around for some time and evolved greatly. It's especially interesting when you input text about the BP Oil Spill.
Viagra was discovered by accident (it was a heart medicine that didn't work out). And I've never understood why it's sneered at. Are there really that many people out there who could face no sex again ever and shrug it off? I think that would be utterly soul-crushing, worse than most of the diseases they have charity walks and telethons for.
they know how to report bugs to browser developers?
Space'n'shopping, I meant ;-)
http://en.wikipedia.org/wiki/Bhopal_disaster
"confirmed a total of 3,787 deaths related to the gas release" ... "5,58,125 cases of injury resulting from the disaster, 5,16,406 (92.5%) were minor, 38,478 (6.8%) were temporary partial disablement while 0.7% (~3,900) were severely and permanently disabled"
Yukikaze: Physical Output Device for Spectrum Analyzer
The title should read, "Kerry Kennedy: Almost all of the Exxon Valdez cleanup crew is dead"

Passing this on as CNN fact-checked journalism is disingenuous.
Experimenting with Multitouch at Second Story (video)
2k of html, 20k of CSS, impressive!

When is firefox scheduled to be able to render things like that, will 3.7 do it?
This is interesting... seeing that the change list does indeed only show that bug 574905.

What I'd find more interesting though, would be to find out why they decided to skip Fx 3.6.5. There has been quite a number of bugs that was marked fixed with that code. I wonder if those are included in 3.6.6: https://bugzilla.mozilla.org/buglist.cgi?quicksearch=ALL%20s...
Government sucks at innovation? What are you talking about? Pretty much everything that is basic science is paid by government in every nation. It is govt that gave us the internet, the bomb, and the man on the moon. Virtually every nobel prize in history has been given to people who worked for public universities.
Well, aren't we a feisty bucket of crabs. (patio11 brought up this metaphor - and it's perfect.)

People, if you're here on HN, you spend a lot of time devoted to reading about the importance of confidence. That it's the entrepreneur's stock in trade. Hell, maybe you even write your own blog posts about the importance of confidence & post them here, hoping for attention.

But what do you do when the chips are down and you come across somebody who truly embodies them? Clatter your claws and try to pull them back in:

"HA HA" "Oh so he's like Brad Pitt now?" "Wow, 2 app store hits, whatever" "Hope he likes having no clients!" "I would never hire him" "DOUCHE!" "What a jerk" "I'm gonna judge him just by this essay and assume that he has none of the actual qualifications or experience he mentions"

The power of belief-action congruity at work. Or not.

If you want to be successful, and you believe having confidence is part of that, then you better figure out of your words and your deeds line up. Because if they don't, you are never going to get what _you_ want.

Now, I've never charged $1k/hr... but almost. And if you return true business value, that is totally a reasonable number. Remember - it's all about the value returned. That's another HN belief, isn't it?

When I returned to consulting after two years in traditional employment, after many years of lackluster freelancing, I raised my rates from $80 to $200 to $250 to $300 to $400 and beyond. My last project came damn close to $1k/hr after all said & done.

And you know what? My clients loved it. They kept coming back for more. They loved my work and thought the prices were reasonable, because there's nobody out there doing what I do in that price point.

(My only true competition in that space was Stamen - a mid-sized agency compared to little old me and my husband, an intimate 2-person team. Who competes with Mike Lee on what he offers in that blog post?)

I would keep raising my rates and I would have started talking about it, too, except that I don't want to consult any more. The more you charge, the more people need you, the harder it is to say no to projects that promise to put a quick $40k in your pocket.

The moral of the story is: most freelancers are lazy, unprofessional, with their interests completely divided, and have little to no real-life experience to back up their years spent coding in the basement. They undercharge, take on too much, and then produce merely mediocre work. They have no true value proposition other than a body that types the special arcane symbols, and asks the client the occasional question. They have no connections.

Believe it or not, there are many companies out there who will gladly pay for an experience that is entirely the opposite of that.
http://en.wikipedia.org/wiki/Blowing_a_raspberry
Declaring two different types on the same line is fraught with confusion, so it is to be avoided.
This explanation needs to be on the website, it cleared up some confusion for me. I was franticly looking for a "read more" link or an "about" page, clicking "start now" didn't really help me understand why I'd want to use your service.