skysight-inc/HackerNews huggingface dataset:
For some reason I can't reply to carbocation, but in reply to his objection that stem cells wouldn't help due to the autoimmune issue, there's a lab that claims to have solved that problem in mice. Apparently, when you get rid of the autoimmune cells, the insulin-producing beta cells grow back. The lab claims to have had a successful phase I (human) trial. If they're right, stem cells are irrelevant. I don't know enough to really evaluate this, but these are definitely serious people.

Here's the lab: http://www.faustmanlab.org/index.html

There's research going on for MS, another autoimmune disease, which also involves getting rid of the autoimmune cells. Here's one approach: http://en.wikipedia.org/wiki/Tovaxin

If they can get this kind of thing right, we'll live to see many autoimmune diseases cured.
One is called "Signal Radar". I found it by searching for "cell tower" in the market, first hit.
Barry Marshall did not have to convince Glaxo Kline Smith. He had to convince other doctors and scientists. I don't believe that companies can often keep genies in bottles, but dogma and groupthink is another matter.
Why do you need write access to my account?
Yep, it's a bit of a rant, but an interesting one. Wozniak's an interesting person; I hope you've checked out Supermemo and its open-source counterpart, Mnemosyne.

I've been taking a 20-45 minute nap in the afternoon for close to a year now. I think it was Dustin Curtis's article on polyphasic sleep that prompted me, and I went with the "siesta" schedule because it seemed the most sustainable -- a lot of people do live that way, and getting work done in the mid-afternoon is hopeless for me anyway.
There are torrents with Vmware images with preinstalled OS X (including 10.6).

BTW as far as I understand running OS X on non Apple hardware is forbidden in the EULA.
Write access is needed because of a feature where you can post replies, favorite, or new posts. This feature isn't turned on in the beta but is planned for future releases. I should have figured this might concern some people starting off. No ill intent is intended. Thanks for the feedback, I will need to turn this off prior to a second release.
Excellent! This is the type of thing that gets me more excited, because it's treatment targeted at the cause of the disorder. (Stem cells will be so for certain diseases, too.) I hope they succeed.
Where Bostonians take photos vs. where tourists take photos
The average cologne contains 14 secret chemicals, 4 hormone disruptors
Welcome to the market! I'm a founder at a company that has been in the reverse auction services game for about three years, and I don't think it's lame at all :)

Don't take money until you have to. We managed to self-fund our venture by building a founder team (four of us) with different skill-sets: sales, operations, management, and technology/development, each willing to contribute sweat equity and our own cash to make it work. I know a lot of people will disagree with me here, but I can only testify to what has worked for us. I love having three other founders who I often disagree with. Technology people often need a reality check. Refining your core algorithms doesn't necessarily ship a product. In other words, I like having someone to push me to build what sells, rather than what's interesting.

What type of reverse auction space are you entering? Are you building a self-service tool? Consulting and SaaS? Our company focuses on the latter, and we've been pretty happy with the results. We're not on course to become another Google, but that wasn't really our goal. We'd be happy with a buy out from a large consulting firm after a few years.

Another piece of advice would be to have a look around at the big competition: Oracle, SAP, Ariba, etc. They've created several healthy niche markets by building really huge products that a lot of large-mid-sized (and smaller) can't use effectively, because they don't have the quarter-million dollar budgets required to implement.

There is still a lot of room for new products and new providers in this market. I think small-scope, focused purchasing facilitation tools are only going to become more popular as time goes on. Have a look at the tools and services that technology people use. We tie together services from at least five different small service providers to build our technology stack. Why can't purchasing do the same? Why must someone buy a $250k license from one of the big guys? As more technology savvy users move in to the workplace, the future becomes brighter for providers like us.
Only that I did the usesthis interview a couple of months ago -- I'm using thunderbird 3 now.
And, from the user's perspective,

* Your password isn't 45 characters of ancient Aramaic. (Why hello, OpenID.)
Bring back the biospace chain drive
summary of the history of the biospace chain drive for bicycles. "Better than round".
Sleeping biphasically for 7 hours or so works because that's what humans are wired for. Maybe taking two or three naps instead of one is better than taking none at all, but without the sleep dep you might as well just go biphasic. The main selling point of polyphasic is the sleep dep.
I rewrote rxvt in javascript. http://github.com/paddymul/rxvt-js
ther terminal emulator is capable of displaying streaming connections, but I haven't built the server backend to enable it.
Pavlina's ex-wife and business partner is a telephone psychic. Pavlina has extensive blog posts in which he takes her occupation seriously. He's a garden variety crank, frankly.
don't you like having a complete IDE to help you out?

Not really. Before I moved to FreeBSD I used Watcom and MSVC, and I don't feel that I'm missing anything they ever gave me. I get syntax highlighting and open-close matching from kwrite, and everything else I ever want I can do with a shell, make, grep, etc.
I believe the story of Lipitor involved Pfizer not being interested, followed by the creation of a startup around it's further development with the company eventually being bought by Pfizer. It then became the top-selling branded pharmaceutical in the world [1]. I guess the world just needs more dreamers like these people.

[1] http://en.wikipedia.org/wiki/Atorvastatin (yes, a wikipedia reference)
A steal at a thousand dollars ?
I have Type 1 and would consider an actual cure a great deal even if it cost everything I own plus my entire earnings for 10 years.
Yes, I usually have at least 5 Konsole windows open on various desktops.
Ok, based on the other responses, it seems this line confused more than just me:

Which brings me to my question, why bother asking the user to login, why not email them a unique, random, url (a https one of course) that once clicked authenticates them. The idea being that only the user would have access to it(or anyone with access to that email account).
I mean that things just don't look or act right. Try firing up Quartz Debug (if you have a Mac), setting the UI Resolution scale factor to 2, and restarting some apps. Every app I checked has problems.

For example, every app that used a standard Mac toolbar draws it incorrectly. Address Book's split views do not resize correctly. iCal's colored checkboxes are incorrect, and the popout from double-clicking a calendar item is very broken. In Safari, the busy icon on tabs isn't drawn correctly, the Top Sites search box is clipped, and the Bookmarks bottom toolbar is drawn incorrectly. The Dock puts right-click menus in the wrong place and draws them wrong, and handles drag and drop incorrectly. Finder doesn't scale the desktop icons. Preview's notion of "Actual Size" doesn't honor the UI Resolution scale factor.

Outside of Apple apps, I find that Photoshop ignores clicks on the menu bar entirely. OmniGraffle's toolbar is extra-broken, the disclosure triangles in its palettes don't work, and it draws the contents of documents incorrectly.

World of Warcraft scales up more than 2x. I can't even get to the username/password boxes. (This could be a feature.) Sketchup draws my document in the lower-left quarter of the window and random junk from the WoW login screen on the other three quarters.

Contrast this to the iPhone 4 experience. Every app I've tried looks at least as good on iPhone 4 as on iPhone 3GS, and none has had any drawing or behavior defects.
Yep, that's what I've been hearing. Right now the main thing holding me back from upgrading is inertia.
> Look up the story of Henriette Lacks and her family's reactions to finding out scientists were using her cells in all kinds of experiments.

As I said, apart from privacy and monetization, so what?

Note - I think that her family should be paid. I also think that she had some privacy rights that were violated.
Well, yeah, insulin sensing leads to adipogenesis. Since the PPAR agonists increase insulin sensitivity, you're going to become fatter if you continue overeating. This sort of brings us back to the root cause of most DM (overeating). And while some of the PPAR agonists kill people, it does not seem to be a class effect; pioglitazone looks OK. (CHF is a class effect of the thiazoladinediones, but it's a more balanced tradeoff with diabetes.)
Tips for Finding the Elusive Angel Investor
The only thing that can kill facebook (if nothing changes about the product itself, i.e. the same growth and same increasing utility) would be people losing interest in social interaction.
Well said. Another failing arises from just how complicated biology is, and how little we understand of it. Unlike in computer programming, in biology reliable layers of abstraction do not yet exist. The equivalent of changing one line of code in a cell's program (through a drug, gene, whatever) in a sense has unknown side-effects on every other line of code. A programmer's approach to working with or trying to understand such a system quickly leads to maddening (and unsupported) conclusions.
C#

Console.ReadLine().Split().Where( word => word.EndsWith("ing"))
.ForEach( word => Console.WriteLine(word));
That blog post is comparing a glossy LED to a matte non-LED display. Big difference, and one I know about first hand because I own MacBook Pros with both types of display, only my LED is matte.

Personally, it's incredibly rare for me to be using a laptop outside on a sunny day, so even if glossy were better in sunlight, I'd never base my decision on that fact. But I can tell you that I did get to compare a matte and glossy MBP of the exact same model in an Apple store, side by side, and saw no significant difference in brigntness.
That's a big problem with Apple nowadays. They offer two desktops that don't have a built-in display, and there's a huge gap between the humble Mac mini and the Mac Pro. And I fear it's getting worse now that they focus so much on the mobile market.

We need a couple of new Performas...
My notes didn't get deleted, although not all of them synced.
Do only democracies have anti-immigrant movements?
"The companies that shape our culture – Microsoft, Apple, Yahoo, Google, Facebook, etc. – are almost always started in a dorm room."

Yeah but Craigslist, Amazon, Wikipedia, ... were not started by 20 year-olds. Ok, last one is not a company...

Some interesting related links:

http://en.wikipedia.org/wiki/Late_bloomer

And in mathematics:

http://mathoverflow.net/questions/3591/mathematicians-who-we...
The Apps Script editor in spreadsheets seems pretty good actually. It does "intellisense" style code completing.
jsbin! jsbin.com for a demo and http://github.com/remy/jsbin for the source
* I don't think even the best current technology can give the feedback of "being there". The topmost leaders of countries still matter a lot and there's no working technology that can give the effect of one leader patting the other on the back.

* The conferences are symbolic. They send the signal that the various leaders are in some kind of accord. Politicians could and sometimes do hold the conferences in places where mass demonstrations are impossible - like Dubai. They are holding the conference in Toronto as a symbol that they can hold it in Toronto. [edit: wrong city...]

* The conferences provide funding, a pretext and a fairly safe venue for law enforcement to test it's latest tactics and overall readiness for more serious unrest. Sure it's "an inefficient way to spend tax payers money" but the leaders only talk about that when their friend's pet projects aren't involved (note how US Federal spending is heading towards 50% of GDP without the government providing basic welfare state type services).
> I don't think it's crazy to think that there are many influential people and organizations that have a strong interest in seeing that we avoid potential cures for common diseases.

I do.

How about some evidence show that this has happened more than a handful of times in the last 20 years?

Note a company refusing to fund a competitor is NOT evidence of "avoid potential cure". Heck - a company refusing to fund something for eany reason is not evidence.

The act that you need to document must be someone going out of their way to block something, not merely refusing to help.
But he wants to live within a budget. If he goes to a place where he's guaranteed a beating during winter, his budget will be blown if heating prices greatly increase. A human being can survive hot, humid days without AC. But sub-zero cold without heat? His computers would probably not function, he'd be too miserable to work, and he'd have cold -- if not frozen -- water. I've lived in places during winter when the boiler has broken in an apartment building. I'd rather go without AC in summer than without heat in winter.
The CPU sure, but I'm wondering how usable the graphics card would be, it not being one of the graphics cards that ships with a Mac. It'd suck having am lack of drivers be a bottleneck.
I don't know if it would completely "kill" Facebook, but there would be a dramatic drop in usage if Zynga (Farmville,Mafia Wars,etc.) fell off the face of the earth.
more like 1000s of millions. It's incredibly expensive to demonstrate safety and efficacy, and many promising candidates fail at the later stages (after 100s of millions already spent) when the response in humans is different from that of animal models.

http://en.wikipedia.org/wiki/Drug_development
Flagged, not because I don't care about his problem, but because I have no idea what happened other than the fact that he lost some data. As it stands, nothing more than flame-bait.
I would actually not recommend econometrics as the OP seems to just start out in this area. My recommendation is: get to know the data, learn what is available, read the definitions/construction methods, plot it in so many ways, do simple statistical summaries, for subperiods, for the entire sample, nothing fancy. One caution though: Try to do so _before_ making up your mind as to what explains the world, and even more important, try to forget everything you've already been programmed to read into the data. It's like in some karate movie, you have to "empty your mind" and let the data come to you, and if you let it sink in, at some point, you will start to ask questions and seek your own answers. I think that's a better way than to be presented with one or two general frameworks and then force fed so many specific models and examples that invariably one ends up seeing the world and asking the same questions like "them".

One concrete example is "aggregate demand". It's a concept presented in the most basic textbooks as a "fact" but it's really an artifact. Fischer Black claimed that the more he thought about it, the less he understood how one could distinguish between "aggregate supply" and "aggregate demand", yet economics is taught like that in every basic textbook I have seen so far. There are very few "facts" in finance and economics, so for the beginner, before consulting what others have thought, I would recommend first having an unadulterated look at the facts before reading explanations or stories.
I don't mind anyone using or saying that they use Chrome. It is a great browser that is making improvements very quickly.

I can also understand people trying out a different browser because they are having problems with their current browser. That is why many people moved from IE to Firefox.

The way this particular comment was worded however, suggests that he was suddenly experiencing a problem with a feature that does not exist in Firefox 3.6.4 on Mac. That lead me to suspect the motives of his post.

The problem I have is with certain types of evangelism. For example:

Some people will exaggerate the problem they have had with competing software.

Some people will take other people's problems and comment as if it were problems they had seen first hand.

Some people will downplay problems that they have with the software they are currently evangelizing.

It happened with people evangelizing Firefox over IE. It happens with the people who evangelizing pretty much anything.

The parent poster replied that he is experiencing a problem that is different from what the article described. I'm sorry to hear that. I'd offer to help him try to resolve the problem, but it sounds like he decided that switching browsers was the right choice for him.

It's a bit frustrating for me because after ten years, Firefox developers are still working their butts off to try to make a great browser that gives people privacy, flexibility, and performance. There are hundreds of millions of Firefox users out there, and if only one percent of them experience a problem and take to the web to complain about it, that is four and a half million people complaining which creates an echo that is tough to deal with.

If one percent of the tens of millions of people using Chrome have a problem that they complain about on the web, that is half a million, and it is a whisper comparatively speaking.

One of the biggest tools Chrome has in its arsenal is it's capability to silently update their browser. If people experience a problem that is easy for Chrome developers to reproduce and solve, they can push it out quickly to stop the problem.

The silent update mechanism doesn't seem proper to some people at Mozilla though. It takes a lot of control away from the user, and it uses tricks in Windows to get around security controls that prevent it. Mozilla has instead thrown time and effort at being able to turn new releases around quicker than ever, as proved by the 3.6.6 release coming out less than a week after the previous release, and only a few days after a problem that affected millions of users was discovered.

Mozilla has also been pouring time and effort into enhancing their ability to detect and understand crashes and other problems. I know because I'm very involved with the Socorro crash reporting project.

Anyway, I think I've long since reached the point of babbling so I'll shut it. :)
Right, I was about to say Vim myself. Especially with the project manager plugin and NERDTree - it works like charm. I am on Windows and Putty is always a life-saver for me.
Bucky Fuller would disagree. Money stands for something—the real wealth of technology and information. As we continue to create and improve quality of life the real amount of capital in the world increases.

I always liked to imagine that, ideally, an inflating currency would proxy for this real wealth-generation, but that doesn't quite seem to be the case.

Anyway, the important thing is that we're not (simply) printing money. The world gets richer.
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Meh.

I get where he's coming from, really I do. I strive to keep that attitude as well, and I put my money where my mouth is by actively living that life, not just writing about it or thinking about it from a distance. I'm the guy getting the fist bump, not the guy trying to remember how to give one.

Having said that, and agreeing with the general sentiment he is making, you can only take this thing so far. At some point, being alive for a year should give you some kind of insight you didn't have at the beginning of the year. If not, you're turnip.

As I get more and more inside of the startup community, as I finally begin to start feeling like I am figuring this thing out, I'm beginning to separate the external "business of startups" guys from the guys actually having a startup. The external guys all have googly eyes, romantic writing, praise of youth, and run in herds. The internal, real-world guys don't have time for all that bullshit and simply go get the job done. That means taking the baggage you have -- both good and bad -- and working with it.

I sure hope I am different now than before, and I sure hope I continue to be different as time moves on. Yes, youth and naiveté are a critical requirement for creating that change-the-world startup, but they are not a sufficient requirement for it. The reason startups work so well for 20-somethings is that you can throw a thousand of them at a problem and then pick out the 2 that fix it, not that somehow youth and attitude carry the day. It's a numbers game. It's the same reason that we pick 20-somethings to run up the beach on D-Day. Somebody has to take the beach, and more likely than not it's going to be somebody who never really understood what the hell they were getting into.
I'm sorry that I misunderstood your purpose then.

I'm also sorry that you are having problem running Flash in Firefox. There are a lot of good articles in support.mozilla.org that might help you, and you could also check out your about:crashes tab and check if any of your crashes have been linked with bugs that indicate what the problem is or whether it might have a resolution.

Flash crashes are a frustrating experience both for the browser user and the browser creator. Firefox devs have worked tirelessly to try to insulate the browser from this problem, and they continue to make further improvements. Adobe has many engineers that look at Socorro data to try to find and fix their product's crashes as well, but it is still something that way too many people bump into far too frequently.
When Capitalism Meets Cannabis
... as is running a VM instance of OS X on anything but the following: VM OS X Server (guest) on an OS X Server (host).
Since we're comparing anecdotal evidence, for the past 10 years I've been contracting at all manner of large banks, finance companies, telcos, payment processors, and healthcare. They are overwhelmingly using Linux, and mostly Red Hat, in their data centers now. In the early 2000s it was mostly Solaris on Sparc on the back end, but in the last 10 years it has switched to mostly Linux on x86-64, with a smattering of Solaris 10 to run "legacy" applications.

Of course they also run Windows, but it's only for Exchange, Windows file servers, and Active Directory for desktops.

Your environment running only HPUX, Solaris, and Windows, is far from the norm. Linux is widely supported, and most importantly, cheap, compared to HPUX or Solaris (running on custom hardware like Itanium or Sparc).
These aren't the droids you're looking for...

(pun not intended, but it's apropos)
Unless you get bored with your friends, I don't know if this much applies apart from the facebook apps.
Firefox point releases are versioned to match Gecko platform releases:

Gecko 1.9.2.4 -> Firefox 3.6.4
Gecko 1.9.2.6 -> Firefox 3.6.6

The Gecko 1.9.2.5 branch was created for a Mobile Firefox security release (Fennec 1.0.1). This did not affect Firefox 3.6, so there was no Firefox 3.6.5 release: http://christian.legnitto.com/blog/2010/06/09/heads-up-the-n...

[Note: I am a member of the Mozilla Mobile team.]
Spreadsheets are not drugs. Mostly.

Developing and deploying a spreadsheet is cheaper and less risky than developing and deploying a completely new drug.
So with the Vmware it would be possible to develop Iphone apps on the PC?
Good point - simply take # of PCs receiving updates + number of Volume licenses sold. That = total number of operating copies of Windows.