skysight-inc/HackerNews huggingface dataset:
NYC Biotech HistoWiz (YC W16) Is Hiring a Lead Engineer / Future CTO
Histowiz is a Y Combinator backed biotechnology company in NYC looking for a superstar full-stack Lead Engineer to build an intelligent tissue platform to fight cancer cooperatively instead of individually. The developer will work directly on our core software to provide a high-quality experience to our customers.

Since inception in 2013, we have 1000+ customers from top academic institutes (e.g. MSKCC, Harvard, Cornell, MIT, Dana Farber, Johns Hopkins, Stanford, UC Berkeley, the Jackson Lab, HHMI, Cancer Research UK) and pharmas (e.g. Pfizer, Novo Nordisk, Regeneron, Alexion) around the world. In addition, we've accumulated the world’s largest, most comprehensive online pathology database.

This database enables tissue-driven data mining for the first time and the development of machine learning tools based on histopathology images for cancer diagnosis and prognosis. Our vision is to combine biology with computer science and bring cutting-edge technologies to biomedicine.

Responsibilities:

● Increase customer satisfaction by improving UX and build new features

● Proactively identify and fix bugs

● Setup automate testing to ensure reliable service

● Provide technical support to lab staff

Requirements:

● Degree in computer science

● HTML, CSS, Javascript, and front-end MVC frameworks (Ember.js, Angular.js...)

● 3-5 years of experience in building scalable web applications, Flask, Python, MySQL

● Linux and dev ops (bash, git, continuous integration, automated testing) experience

● Experience with AWS (EC2, S3, CloudFormation, CloudFront)

● Effectively communicate technical issues with customers and non-technical colleagues

Location: Must be based in the NYC area or willing to relocate to NYC to work in person.

Prior experience with early stage startups, computer vision, statistics, and machine learning is a plus.

We believe in investing in our employees’ professional development, and we encourage networking within the software, tech, and startup communities for all of our employees and collaborators. In addition, we provide the time and freedom to pursue independent projects.

We offer a tremendous growth opportunity, flexibility, and independence. We are seasoned scientists with experience at the world’s leading academic institutions, and have published high impact research in top journals of biomedicine such as Nature and Cell.

Compensation is top-notch and generous equity is available, commensurate with the impact you have within our organization. Full coverage of health, vision and dental insurance, 3 weeks paid time off & paid company holidays.

If interested, please email a resume to will@histowiz.com and cc ke@histowiz.com. For expedited consideration, include a link to sample code. This could be something personal or contributions to a library preferably written in Python and hosted on Github.

histowiz.com
The benefit is mostly limited to the $3,000 tax deduction, so as that approaches 0% of your growing savings, the fee isn't recouped by TLH.
The main problem is that TLH tops out at $3,000/yr in losses. After that the benefit doesn't scale with the fee.
How do you use Project Piglet to inform your investing decisions? The examples don't seem very enlightening. I'm slightly confused that it's registering a positive sentiment for Uber, too.
After I turned 50 the faculty and administration of MIT got real friendly about alumni legacy grants. Before then they barely gave you the time of day.
Sure, but that's an extreme example. Zuckerberg's at 10 figures, not 7.
In theory a flywheel should be smaller and virtually maintenance free. Or maybe it's just cooler and more expensive.
This is precisely why both doctors and attorneys are considered 'professions' - as they both have articulated professional obligations that are primary to their making money. They both have duties of either care, or of law to their client, even and especially when those duties conflict with them making more money. If you chose the more money of standard of care, or more money over the client's interest, you lose your professional license. In the context of a financial advisor, that duty should be fiduciary in nature, but as there is no professional obligation, no recourse for failure to keep that obligation, you have a race to the bottom.
Great question ! I have often wondered that too.

I can understand small companies, trying to cover up the fact that they are still operating out of their garage or spare room. But when large corporations do it, I am just flummoxed. For example if you look up Apple in the Sydney (AU) whitepages, there is no address given just a free call number. I just checked, Google now show their address, but in the past they didn't either.
The problem is not bias, but uneven representation. We can get uneven representation without bias quite easily: I've not ran your system in practical terms, but I'd be very surprised if, in the US, this gave you republican house majorities even when they lose the popular vote. The reason is simple: Republican voters are more dispersed geographically, so it's very hard for them to get clumped into a district where they have an overwhelming advantage.

This is why plenty of people prefer to do things like maximize the chance that a voter feels well represented, or minimize the safety of incumbents, instead of going for something that leads to simple lines.

Another important problem of straight lines is that it ignores the physical limitations of actual voting: Each voting location is expensive (go ask in North Carolina, where magical budget cuts make it harder to vote in areas that tend to vote democratic). inconvenient, mathematical lines will give you higher average costs to get to your own polling place, and will require more polling places, or places that have to corral different people to different booths with different options. Good luck doing that without doing everything fully digitally, which is, IMO, not necessarily a good idea.
Ah, so these freaks already managed to make claims. I hope someone will work on busting them. I highly doubt HLS is in any better shape in this regard.

And Columbia University is in that patent trolls list. Disgusting.

UPDATE:

Going through that site, I found their attempt to leech on VC-1: http://www.mpegla.com/main/programs/VC1/Documents/vc-1-att1....

And they list Microsoft there, which is strange, since MS are part of Alliance for Open Media which is an antithesis of this trolling cartel. Either MS are sitting on both chairs, or MPEGLA are trying to fool everyone.
To be fair, it was "build" more than "assemble." Article says they just bought solid wood doors, pieces of 4x4 for the legs, and metal brackets.
Maybe "stupid", then.
It's possible that if a company is very small, it works out of a co-working space or has all of its employees working remotely in different locations. They may be hiding this to make it appear to customers that they're bigger than they really are.

But I agree that not telling prospective employees where they're located will deter people from applying. For example, two places within a few miles of each other in NYC can have drastically different commutes (time, comfort and/or safety), so there's no way I'd consider applying for a job if I didn't know the company's location.
Well actually, I would. But not for webapps.

There's a fairly large class of scientific computing oriented apps where having a widely deployed and fast VM with CPython compatibility would be fantastic. Python (for better or worse) has a large library of open source computational libraries, but shipping an embedded CPython VM is a pain. As an example, I helped advise an undergrad working on a program to calculate collagen fiber orientation for biomedical research labs. Figuring out cxfreeze or other Python packaging systems took longer than writing the actual app.

Unfortunately JavaScript doesn't have broad scientific library support and grad students in non-CS fields don't always have the time to become versed enough in C/C++ to create a usable app. So CPython & associated C libraries ported to wasm could be quite useful... This could apply to R programs as well.

Re: grandparent, just because a project offends your sense of purity doesn't mean it isn't surprisingly valuable for others.
My work drives me insane. I cycle home. 30 minutes of fairly vigorous exercise and it melts away. I realise this isn't an option for many due to location, but it works for me.
The problem is gerrymandering results in only one district that's 90-10 while 9 other districts are 55-45.

Without gerrymandering, districts would have a normal distribution from 60-40 to 40-60.
Mark Zuckerberg generously gave 100M to improve the education system of Camden New Jersey. At the time the mayor was Stanford grad Cory Booker, now Senator, and future Presidential material. Camden was and still is a minority shithole of New Jersey. Neither Mark's generous gift nor Cory's public service had a lasting effect. Deeper structural problems. I do not know the answer.
Trust me, if you leave alone instead of letting it go - you'll revisit. Over. And over. And over.

And it's going to be a little bit worse every single time. Find closure.
Why is the Ubuntu route too difficult?
Russia showcases the first computers based on its indigenous Elbrus-8S processor
Or a single donation of that size to another single school that is far more in need than MIT. for example on could donate it to the Tribal Colleges system and make an unbelievable impact on the lives of many criminally oppressed native communities.
More cars is not a solution in any way to climate change, no matter what they are. It helps such a tiny amount, and will probably add more problems as people switch over.
>The largest gift to MIT was pledged in 2000, when International Data Group founder and chairman Patrick McGovern Jr. , and his wife Lore Harp McGovern, committed $350 million over 20 years for a brain research institute.

Wasn't the the donation of the majority share in Bose much larger than $350 million over 20 years?
Is this like.. where you choose 1, 2, 3?

so if I choose

1. Dem
2. Green
3. Repub

and you chose

1. Repub
2. Green
3. Dem

They'd all be equal? (four points each)
Huh, that's an interesting thought.

Imagine Cupertino had (nearly) finished designing this sleek machine, thought it was a wonderful answer to refresh their Mac Pro, then they get completely railed in January for failing to provide professionals a pro machine when they expected it. They're late, they know it, but no biggie - they'll introduce this pro machine this summer and everyone will love it.

The pros then proceed to articulate exactly what their grievances are, and the machine that is sitting under the black cloth in the back room looks nothing like what their most loyal users are hurting for. And if listened to closely, the machine that's mostly finished is actually an insult to their most valuable customers. What do you do in that case? Completely scrap the beautiful machine you've already made? Or eat (silent) crow and promise a completely new product that you start working on tomorrow, and tell the engineers who were working on their pet dream computer to quickly finish up - let it be introduced mid-keynote by a non-executive, go back and painfully re-etch a diminutive 'i' in on each of the just-printed 'Mac Pro' bezels - likely to never recoup their R&D costs on this 'lost' product.

That's a good point. I bet that's exactly what happened here. Because if Cook would have given this exact keynote, but had introduced this grey iMac as their 'next new thing' that was replacing the Mac Pro, he'd have been booed off his own stage during Apple's most sacred moment. Apple had enough sense to avoid that moment. They have enough cash to produce an entire (temporary) product line that loses money. They don't have enough cash to lose their most die-hard and influential customers en masse and hear a crowd of 'boos' at the height of their hallowed keynote.
My Japanese native language speaker in college had an obsession with the word "squirrel". We spent an entire year trying to teach her how to pronounce it.

Ssss-ka-wuh-rrr-llll
To prevent crazy people from doing something crazy. These buildings aren't open to the public. Outside of your employment use case (in that case just ask the recruiter for the building location; I've never had a problem with that), the people trying to show up to an office building are probably trying to complain or make a scene.
A Reverse Engineering Crash Course on X86 Assembly: Part 1 Intro to Registers
Interesting concept! I wonder if this is hackable based on demographic popularity of last names, by race. According to Wolfram Alpha, the most common last names are: Smith, Johnson, Williams, Brown, Jones, which don't share a common 1st letter. But maybe some ethnic names might: Rodriguez, Ramirez, Chan, Chen, Chang...

But ultimately, what political needs would a community of last-name-starts-with-C need?
Maybe even having a system that makes more than two choices viable?
She has made the remark repeatedly, over the years, in different contexts. It's not a throwaway.

As for baseless hyperbole, I object to Atwood on this issue because she is 'borrowing' ideas from a genre that she is then disassociating herself from. Delany and Walton could expect their readers to have read Melville and Greek myth, but Atwood is delivering SF a nice little kicking while borrowing the ideas from the genre and transporting them to a more respectable context.

Apparently The Man in the High Castle is still SF, probably because Dick didn't strain at the oars to get shelved out of SF. Probably because he was a repeat offender with talking squids in outer space and worse - telepathic slime molds from Ganymede, IIRC.

Partly it's also a matter of taste. For someone so 'literary', I'd say that Atwood loves herself some serious schlock. It felt like every third character in the Oryx and Crake trilogy was Torn From the Headlines of whatever outrage articles that Atwood had read in the previous year... I keep dutifully reading each book - there's always something interesting in them - but I've got to say I feel both dirtier (Oryx and Crake trilogy) and stupider (the trilogy + Heart Goes Last) after each one.
[cross posted from the article comments section]

I'm currently working on my PhD with an emphasis on formal verification (more specifically proofs of correctness) in the weak memory setting.

Some thoughts as I read through:

> Any number of compiler optimizations. For example, our model currently does not account for compiler optimizations that hoist identical stores from both branches of an if statement to precede that statement.

This has until very recently (POPL 2017) been a very serious problem for formal weak memory models. There is only one that I'm aware of for C++11 that avoids the "thin air" read problem that generally arises as a consequence of supporting these types of optimizations. See [1] for more.

> The memory model must be compatible with the hardware that the Linux kernel runs on. Although the memory model can be (and is) looser than any given instance of hardware, it absolutely must not be more strict. In other words, the memory model must in some sense provide the least common denominator of the guarantees of all memory models of all CPU families that run the Linux kernel.

This sort of "lower bound" on bad memory behavior is normally why people target C11 or C++11, but if the author's happen to see this comment I would recommend checking out the work of Karl Crary at CMU [2]. In his model he has omitted the traditional total order on writes present on all modern architectures with the intent of future proofing his semantics.

As a further plug for his semantics, it is not "axiomatic" in the sense of the traditional memory models. Importantly it introduces the notion of programmer specified orders which fits more closely with programmer intuition (by my reckoning) when writing the algorithms than say, the C++11 approach of memory orderings for particular cross thread operations.

In any event an enjoyable read that I will have to come back to later!

[1] https://people.mpi-sws.org/~orilahav/papers/main.pdf

[2] https://www.cs.cmu.edu/~crary/papers/2015/rmc.pdf
I don't really know how to say this, but there is a survey option to this where they need all of that info for some statistical thing they are doing with this new web app.

I'm using a throwaway nick so my boss won't know I am asking here and using a friend's computer for the IP.
Sapien is a Reddit alternative with built in chat and voice. Closed beta out now
Dark pools & other approaches which avoid sucking liquidity out of public order books are available.

These allow larger trades to be done without affecting the market price.
">Are there any good frameworks that allow for processing, caching, data visualization (layout -> data population -> rendering), then exporting to some format (PNG/PDF/TeX)?"

I use SAS for this in my Day Job it's not a free program but powerful for this type of stuff.

I typically use SQL queries (via SAS's proc sql command) to manipulate and process my data but you can also programatically manipulate your data sets using SAS's "datastep" language.

SAS has support for macro expansions which make some of your examples (like manipulating 10 sensors at once) pretty trivial. But this is getting into programming language territory I would not expect someone new/unfamiliar with programming to grasp all of this intuitively.

edit: Heres some code I have in production that counts how many (of 8) sensors are reading high in a given time frame.

array aads (*) TP_AD1_TOP_STACK_TC1 -- TP_AD1_TOP_STACK_TC8;
NO_AD1_TEMPERATURES_HIGH = 0;
do j= 1 to dim(aads); if aads(j) gt 160 then NO_AD1_TEMPERATURES_HIGH = NO_AD1_TEMPERATURES_HIGH +1; end;

Downside is that SAS is a commercial package and it is not free I Have heard a lot of good things about "R" which is supposedly quite similar but have not had opportunity to use it myself.
Relevant analysis from propublica on an algorithm already used to set bond rates:

Black defendants were often predicted to be at a higher risk of recidivism than they actually were. Our analysis found that black defendants who did not recidivate over a two-year period were nearly twice as likely to be misclassified as higher risk compared to their white counterparts (45 percent vs. 23 percent).

White defendants were often predicted to be less risky than they were. Our analysis found that white defendants who re-offended within the next two years were mistakenly labeled low risk almost twice as often as black re-offenders (48 percent vs. 28 percent).

https://www.propublica.org/article/how-we-analyzed-the-compa...
I've found that preferring voice communications is helpful (better that text, slack, email etc)

Also, if they are customer facing, try and have them use templates when possible to minimize the amount of text to write.

If they misspell things, just try to let it slide and focus on the bigger issue.
I hate instant modal popups with a passion. Whenever I get one of those obnoxious modals I try my best to boycott the company and promote alternatives, assuming there's any. When this trend initially started popping up I'd close the modal and read the article, but I've grown increasingly intolerant. Now I close the article immediately unless the content is really important.
I don't hugely disagree, but the person you were responding to was holding up his daily reading of WAPO and Fox News as being representative of real "critical thinking," hence my wanting you to define your terms.

> The void between the american right and the general western left is HUGE

Of course, there's a gap between the American left and the "general western left" as well. In many ways in America we effectively have a center-right party and a far-right party which harbors substantial fringe elements. There is not really much of an American left by any conventional measure. (America's left wing party just ran a hawkish supporter of the death penalty whose husband "reformed" welfare)

> I just don't see the use in digging up hyper-extreme ideology that no one participates in and will literally never see the light of day in my lifetime.

If you don't think the ideas have intrinsic importance that's fair. On the other hand, it appears to go hand in hand with an American culture wherein people don't even realize that Communism and Socialism both used to be a living, active thing in their country. I don't think you can be a "critical thinker" and just ignore all that history and context, but at the same time... yeah, I'm not seeking out the Socialist's newspapers, or whatever.
The parent didn't mention ranked choice voting unless I read it wrong. I read them to argue in favor of multiple representatives per district. You can have that even with the current voting system. The top n candidates get the job with n > 1. There only difference is right now n = 1.
That being said there is also the much simpler approval voting.
If you read the article, it says there are actually two types of gerrymandering. One is "packing" all of a voting block together, and the other is "cracking" a voting block into multiple districts so that it can't win in any of them.
Maybe use text expanders with pre-written snippets. Spell check should be native in the OS no?
You misunderstand my criticism. The reason they aren't "mutually exclusive" is because one of the things that you are calling gerrymandering isn't gerrymandering.
There is low level good and high level invent nuclear fusion kinds of good.
"If it's your 10th job and you are feeling like this still, you have to figure out if it is bad luck (it does happen) or if it's something with you."

Or you could have just chosen the wrong career. Simply changing jobs may not be enough.
Archeologists actually have their own versions of UUIDs and massive books/databases cataloguing them. Since dates are constantly subject to revision though, they don't generally use timestamps.
I have a strategy that works pretty consistently - close your eyes and ignore the best practices like using Anaconda, Python 3, virtualenv (or venv in py3... oh wait it's a module?) and just install Python 2.7 with pip into default locations (I even run pip with sudo, the horror). It works really well! I run all sorts of CV, ML, deep learning notebooks with no problems.
But...it's not the degree, it's the knowledge that's important.

MIT, Stanford, and a decent amount of other institutions have made their lectures available for free online. Almost anyone can go online now and watch the lectures and do the projects that the students do.

How would testing centers and degrees make them better scientists in anyway?
Vultr: Digital Ocean alternative
I really like what's offered by Jupyter Lab. It's in alpha right now, but I haven't had too many problems with it. It allows you to open text files, terminals, and notebooks in the interface.
You need to figure out what the underlying issue is. Is it just about work? Are you happy (relatively speaking) when not at work, like weekends?

If not, figure out what's wrong. Could be that you need to change jobs, get extra or better sleep, vitamin-d (helped for me). It could also be that you need some professional help. There's no shame in that.