skysight-inc/HackerNews huggingface dataset:
No two cells are ever genetically identical. Within a common hyper-mutable region, tandem repeats, the mutation rate is 10^-3 to 10^-5. There are over 10^5 tandem repeats in the genome, and therefore at least one mutation is expected for every cell division. Many other types of hyper-mutable regions exist in the human genome.

In this research they only examine one form of genetic variation, SNPs. These findings only reflect a small proportion of the somatic variation present in the body.

There is no real surprise in these results, but the data may nevertheless be useful!
Around The Verse has always been a bit of a letdown, with their total focus on gameplay, art, ship/world design, modeling, etc.

I really wish they'd occasionally give even a cursory nod to the programming team.
> Relative investment and manpower on the issue has plummeted. I can't get into more specific details.

I can. Of course it plummeted since the end of the Cold War, but it raised again in the last 3 years, for obvious reasons. The US is lagging behind (not for long), but other nuclear powers are frantically resuming relevant activities.

> maybe sometimes it is better to just stop learning more about a topic.

It isn't. Methods of learning might be unethical (and thus are not advisable to be pursued), but knowledge itself is beyond ethics.
Lighthouse is Android inventor Andy Rubin’s secret project
I think they mean VR in the sense of Second Life, not in the sense of Oculus.
There is a reason for that and they call it "the latency numbers every programmer should know".
One way around that is to make small random variations in the simulation (sensor calibration, vehicle performance etc.) when you generate the training data, so that your system learns to drive a generic vehicle rather than a very specific one.
> Pound for pound, a MacBook will last longer while doing more than a Windows or Linux laptop, despite Microsoft's and Linus's efforts to rectify this.

The repairable/upgradable thinkpads are probably better in this regard
That is some next level BS.

I feel like there is this secret turf battle between designers and developers, constantly trying to one-up each other, and ultimately take controls away from each other.

Developers come up with frameworks and systems that take controls away from designers.

Then designers come up with frameworks and systems that take some controls back.

Back and forth. Back and forth.

Taking control away may not be the primary goal, and it may even be a byproduct. Nonetheless, it's pretty amusing to observe the trend play out.

Then you watch how the rest of the world design and code their sites at fraction of the cost with better result. I don't know how we get away with this nonsense in America.
I think the implication is that the various scientists influencing the management decisions are "city folk".

I doubt this implication adds much to the conversation but hopefully unconfuses you.
Oh god im an idiot. I meant Spotify. :)
Yep, Microsoft also offers much the same services. Works surprisingly well too.
https://azure.microsoft.com/en-us/services/cognitive-service...
Haven't tried that specifically but I've used tmux and vi quite successfully, including mouse support.
No, the post you are replying to had it correct. The $140M is people paying to have the game, that's the same as boxoffice sales.
Whatever their problem is, they're not the only ones to have it. Japan's been in the doldrums for decades; my understanding is that the country turns a profit, as it were, but doesn't have many opportunities for further investment.

Of course, Japanese capital isn't the only capital that chases stupid stuff, especially not right now. We're all Japan these days. :)
The approach needs to be able to instrument the executable and inspect which code paths it uses, so it won't work across a network.
Cool site. No offense but I would never associate with godaddy unless it was life or death. I saw it was powered by godaddy aftermarket.
"Say you discover data that leads you to suggest a different vaccination procedure."

There are plenty of examples of how accepted treatment is hard to shake. Take for example ^stomach ulcers^. Barry Marshall conducted self experiments to prove the H. pylori theory. The initial work started in '82. Marshall/Warren won the Nobel prize in 2005 [0] for this work. It changed the way stomach ulcers were understood and the treatment.

[0] https://en.wikipedia.org/wiki/Barry_Marshall
I don't understand how a huge collection of evidences of emergent phenomena proves that Nature does not have a plan.
Huzzah and congratulations! I've been eagerly awaiting this. Congrats on the release!
SoftBank is not a telecom, it's a holding company like Berkshire.
Its a one off situation, any number of things could have been at play, the pepper spray could have been a dud, he could have missed in a panic or been too far away, etc.

People going into environments like that need to carry guns, and they need to understand that running away, especially in a panicked manner makes things worse. I'm not saying they aren't dangerous animals, they clearly are. That's why people need to understand how to handle them, its no different from being prepared to climb a mountain.

But hyperbole about needing a mini-gun or you are surely going to die to a pack of wolves is just utter, complete bullshit.
Now they say that it's 100% for neurons. Exact 100% number is also pretty sketchy from statistical standpoint.

What class of problem is searching for duplicates or uniqueness among a set of billions of items? If it is a tractable problem, what is the most effective algorithm?
Ha, now that I would not doubt nearly so much :-)
Urban dwelling? I live in rural Romania.
If the issue is obesity (e.g., you need to shed over a third of your current body weight) then I agree that bariatric surgery is definitely an option to consider. The odds really are against you trying to lose that amount of weight via diet and exercise alone at the parent post suggests.

(Considering surgery is certainly a more helpful suggestion then, "Have you tried eating less and moving more?" like they are the first person to ever tell you that. The way different bodies process things is far more nuanced than that, involving so many factors including hormones, age, gut bacteria and heaps of other things, not just will power. The more we discover about nutrition shows how much we don't know about nutrition. End rant.)

From my own personal experience[1] I would consider a gastric bypass or gastric sleeve, but avoid a lapband - all other factors being equal.

Obviously seek competent advice from medical specialists on the matter before doing something irreversible.

[1] http://www.michevan.id.au/content/adventures-in-bariatric-su...
My bad on the missing 'the'. Mechanism is in the abstract. Of course it is. I see it now. Sorry about that.

Probably wise to mention your PhD here on HN. Nerds (apart from me) are the finest proof readers and grammar checkers the world has ever seen.

Seriously, all the best on your PhD submission. Sorry for the confusion.
If you ever want to chat lmk I come at the world from a pretty anti empiricist angle these days
The case for raising chickens in virtual reality (2014)
Spam filter seems like it might help. If you are an user of that website you should suggest it.
Nobody ever said that all cells share 100% of DNA in the sense you're implying. It's obvious that DNA undergoes dynamic processes, some of which will result in lasting differences. The accumulation of errors is the basic mechanism for cancer, which has been recognised for decades.

But it was previously thought that such differences were detrimental to function (and health). There were some mechanisms for modifying cells' DNA, collectively known as "epigenetics", but these were reversible, at least in principle.

This adds another dimension of complexity, which biology already had plenty of. My favourite is the double- or triple-coding DNA: because DNA is read in triplets, there are three possible reading frames. Some organisms have evolved DNA that produces entirely different, but independently useful proteins on two or even all three reading frames of the same DNA. Talk about efficiency...
Different perspectives, I suppose, but I recommend programming to anyone who has a head for it. Admittedly, perhaps the culture is different away from the big tech hubs or startup culture or what have you. I've only been working in the field a few years in two positions, but both were fairly low-pressure positions with 40-hour workweeks, a few weeks of paid time off, and reasonable but not amazing pay. For reference, I've done ERP development at a CD manufacturer in Pennsauken, NJ, and air traffic software development for the FAA near Atlantic City, NJ.

Seems to me like there are plenty of jobs for people to get into tech and make a decent living, if they prioritize for their happiness rather than compensation or doing something 'cool'.
Thanks! Got that part working. How can you tell if djpeg exits 0 for a given queue item?
It would be interesting to include (but really hard to do) startups that 'exited' through acquisition that failed to clear the liquidation preferences. This sort of exit could also signal a 'mistake not worth repeating'.
That explains the bother I was having trying to add CORS headers today. Not the sort of thing one really wants to get wrong, either. I shall definitely be doing this tomorrow.
There is a group of humans who will take financial responsibility for damage wild animals cause to cars: car insurance companies. In the US, "comprehensive" car insurance covers most kinds of damage or loss other than crashing the car while driving it, including damage caused by animals. It is usually inexpensive.
It's a pretty fascinating result, and it almost seems obvious in hindsight -- a statistical result of entropy which has profound implications for anti-aging research.

The biggest takeaway for me is that physically isolated genetic diseases and asymmetries which manifest during an organism's growth may not be contained whatsoever in the organism's zygotes / passed along to its offspring (not that this was an impossible result before, but I suspect there is a higher probability of genetic independence than previously thought.)

I would love to see comparisons of the standard deviations of "healthful" individuals to less healthy individuals. I would imagine that some genomes are far better at protecting themselves than others.
Recovering from Burnout and Depression
Wait, the headline says no two alike, while the body text seems to go no further than that every cell is potentially different. What is it? If the somatic mutation rate is >1/neuron, that's a real surprise to me, but if it's "there's plenty of mosaicism and it makes a real difference", then not.
Hah, thanks! :D
I don't think OPs post was hypercritical of apple's cash position. It simply reinforces the notion that big companies can't use the cash effectively.

To call it hypercritical of apple isn't exactly accurate. It's simply reality. Apple may even be acting more effectively than most by keeping the cash in reserve. You might imagine they're waiting to spend it intelligently and effectively rather than on a slow-moving corporate machine.

As a shareholder I'd approve of such a strategy 100%.
I bought into SC when they promised Linux support. All this cool stuff that people are getting to play with early is Windows-only. I have significantly less patience with Star Citizen because so far as I'm concerned they've broken their promise.
More coverage from other news sites:

- Wired: http://www.wired.co.uk/article/improbable-quest-to-build-the...

- Bloomberg: https://www.bloomberg.com/news/articles/2017-05-11/softbank-...

- TechCrunch: https://techcrunch.com/2017/05/11/improbable-grabs-502m-led-...

- Financial Times: https://www.ft.com/content/76529d16-3669-11e7-bce4-9023f8c0f...

- Improbable's own announcement: https://improbable.io/2017/05/11/our-ceo-herman-narula-on-ou...

(Disclosure: I work at Improbable.)
Since biologists and evolutionists are liken to gather here, I would like to ask something that's been occurring to me lately: does evolution explain all the things? For example, does it explain my personal musical taste? Or perhaps the aesthetic tastes of those birds that mate based on aesthetic choices? If evolution doesn't explain these and other factors that are involved in natural selection, so we can say that external factors (explained by what?) are involved in the process of evolution, so evolution may be being partially caused by other, non-emergent, forces?

I don't know if this is clear or if it makes sense. Please feel free to say I'm stupid.
VR Studio Improbable Worlds Raises $502M at a $1.04B Valuation
Keybase is utterly unusable since you introduced the chat feature. I use a yubikey to store my gpg key so I get prompted every 5 minutes to enter my pin because for some reason keybase insists on requesting it over and over again even though I'm not even using the applcation.
They probably pitched SoftBank some Sci-Fi inspired "Simulated World."
He said hikers were running, not hunters.
Epigenetics, as has been pointed out. But also just the very basic mechanisms of hormones and other signalling and regulating molecules. DNA is just the code. Cells also keep 'state', mostly through the specific molecules in the cytosol.
Perhaps you could contribute to this open source project? https://github.com/EnterpriseQualityCoding/FizzBuzzEnterpris...
Good catch. We've changed the title above to a representative phrase from (I think) the paragraph you're referring to.
IIRC CR had a bit of a reputation at Origin for not saying "no" to adding features as well.
Well, actually, if a cow hits your car (or your car hits a cow on the road) the rancher is liable. I was applying the same rules to the government.

Most bison in the USA are not wild game animals and have to follow the sames rules as any other ranch animal.
Halo fan turns Cortana into a hologram
The goal of the simulations can be for example to render some particle system or create some procedurally generated content for use in a game. Many of their tutorials are focused on including their technology in game engines such as Unity. Hence, I would rather call it cloud computing for VR.
I wonder if package maintainers will be able to use this as a way to test their packages on multiple distributions from a single test system. That would be pretty cool.

I continue to be impressed with the progress the WSL team has made. The usable open source development environment on top of a kernel that can correctly drive all the various peripheral in the box is so very useful to me.
I'm out of the loop on ARM. Can somebody explain the significance of it?
You can buy SoftBank telecom suscriptions and services [1], with its trademark, while e.g. Berkshire don't sell soft-drinks (Berkshire has Coca-Cola stock, but it is not Cola-Cola). So, in my opinion, it is not the same thing. Not even close.

[1] https://en.wikipedia.org/wiki/SoftBank_Group
That's pretty accurate, yes. To add to your examples:

- Worlds adrift - 100s of instances of Unity running in the background, but it appears to be a single seamless world to players.
15,000 people died because of the tsunami. No one died from the radiation release at Fukushima.

https://en.wikipedia.org/wiki/2011_T%C5%8Dhoku_earthquake_an...
I am once again telling you my statement was about my proposal. I am not talking about any other aspect of ranching.
I wonder how much of deals like this that don't make sense on its surface is based on behind the scene agreements.

"If you invest 100 million in this company we backed two years ago, we'll give you a good deal on this other thing we know you're interested"

"If you back our cloud computing company, we'll get our other unicorns to use your CRM technologies"
Your expectations are probably in line with reality, but Star Citizen does not sell itself as a casino. They entice you to spend money and promise you something great with little mention of risk. I really hope they create a great game, but like a start up that took on too much funding, I have grave concerns.
The title is very clickbaity and should be changed. Not the OPs fault.
Introducing the beta docs.vmware.com portal
It sounds like the only reason you won't buy a pre-release game on Steam is because it's on Steam and nothing else. Every criticism ever levied against early accessed games is a criticism you just excused: "I paid for some entertainment and received it", "I wouldn't really feel cheated". But then you do a total 180: "I will NEVER buy a pre-release game on Steam". Whoa - never?

Nothing separates you from this community: http://store.steampowered.com/app/252490/Rust/ you would fit right in and you'd have just as much fun. Nothing you said passes scrutiny. You're in it for a ride with the developers, and that's what's fun to you. Not the product. And that's ok.
Android does the same thing, both announced a while ago
Whoops, my mistake.

For the record, running from wolves is always a bad idea. Wolves run faster than humans and have a strong instinct to chase anything that runs from them.
If an rancher's cow hits your car then the rancher is liable. I am just applying the same rule to the government. It fits in with the whole "how to get the ranchers not to shoot the wolves". It applies a rule in a fashion equal to the rancher's responsibilities in the situation.
I think East Germany is probably the anti-surveillance sentiment more than 70 year old history.
You're right; this approach wouldn't work with an "opaque peer", as most machines on the Internet would count as.

However, assuming the above sci-fi scenario—a cooperative peer that wants to communicate, but shares no common signalling standards with you—you could assume that everyone is doing broadcasts on loop of their daemon binaries to let their peers analyze them.

This would require some bootstrap logic on each side, to find what signalling methods their peer is using to broadcast the bootstrap. This could be made an approachable problem if everyone assumes everyone else will use "lowest-common denominator" signalling technologies for their bootstrap transmissions (e.g. binary over AM radio.)

You'd also have to figure out the ISA of the recovered binaries, in order to begin to fuzz them. This isn't impossible to do automatically either; it basically requires an "inverted" fuzz process—fuzzing up a VM with various decoding strategies and opcode definitions, and then seeing what it does when fed the provided binary, attempting to find something that produces a "normal" program execution (maybe according to a neural network trained on what memory-states of running programs usually look like.)

---

To jump back out of the sci-fi context, though—if you assume an "opaque peer" that nevertheless has its source code published online somewhere (e.g. as FOSS on GitHub), then you can do something like this:

1. set up a web spider that downloads source code from the internet, compiles it, and then fuzzes the resulting binaries (presumably all in a sandbox) to create mappings between project URLs and fingerprints of behavior under fuzzing.

2. when trying to communicate with an arbitrary server, first fuzz it a bit to try to fingerprint the response using the index.

3. Take the results as a fingerprint; feed them to the index service; get a source URL; clone the relevant project.

4. Fuzz-analyze the source code of the project along with the responses of the live peer, comparing the two as you go to try to get your local "mental model" of the peer as aligned as possible with how it's really behaving. (E.g., use the live peer's responses to generate the config file for your local copy of the project.)

5. With a behavior-matched local copy, generate an IDL client as above. (Which can, of course, be a very easy process if it turns out the server obeys some previously-discovered protocol.)
The auto company will sue the rancher as its his/her problem that livestock got out.
There will always be people who are just "better". They'll learn faster, remember more, and generally make you feel inadequate by comparison.

There are also people who seem like that, but aren't. These people have prior experience and memories that accelerate the speed at which they learn, and leave fewer remaining new concepts to memorize. Over time you'll catch up to this second group, if you apply yourself.
They have been upfront about plans and missed targets for the entire duration - communication is why people are still happy
Source ? I'm french, and I've never heard of this. US used to have silly export laws way back when, but that's been over since 2000.
Just FYI - the purpose of the public posts is (I believe) to leave yourself verifiable by others at any future time. So then nobody has to take Keybase's word for it that Keybase account X is linked to Facebook account Y, because I can just verify it myself with your public post!
Not affiliated with Keybase:

The whole point of Keybase is we don't have to trust Keybase (as a company). The proofs have to be independently verifiable, and an oAuth login wouldn't be.
This attitude makes no sense to me. This is what kickstarter is for: you back high-risk projects, get some goofy schwag, and sometimes the project actually works, and how cool is that?

Why does there seem to be a horde of people who think kickstarter is for pre-ordering finished products and getting pissed when they don't receive them? That's just not what it is!
OTOH Real_S comments that the rate is indeed >1. So huh, I learned something.
Yeah I am surprised they haven't added a rule that you can't give backers something that doesn't exist.

Being able to back something to get that thing seems to confuse to many people into believing it is a shop where you buy things rather than an investing in something you would like to exist, but may never actually exist.
eat yer yogurt folks!
Resistant starch is awesome for your good bacteria as it helps them produce butyrate and other short chain fatty acids that are really good for your gut cells. Excellent video on the subject here: https://nutritionfacts.org/video/getting-starch-to-take-the-...
multicellular organisms began
as cooperative colonies of *CLONES*.

ftfy
Don't put them on a pedestal
If a rancher gets above sale price for a steer, even a pitiful 5%, then that rancher is going to find ways for this steers to get killed by wolves (for example by having them graze on public lands next to a den of wolves).

What incentive would a rancher ever have for preventing the wolves from killing the steers? If the wolves don't kill a steer, well then there's the hassle of taking it to market and getting market price. If the wolves kill the steer, then they get market price plus 5%, and don't have to even find a buyer.
Yeah I believe you are talking about enumerating over the interface versus the concrete class?

(For others) Most of .NET frameworks generic collections implement the enumerator as a struct which doesnt get allocated on the heap and subsequently garbage collected, but the explicit interfaces implementations use a class which does.
Technically, you just need fine-grained enough measurement of the request/response delay, since you could probably use time of response to measure how many instructions had been executed in response to your fuzzed input.

Over the internet, this probably gets lost in the noise, but maybe with enough inputs, it wouldn't.
I'm not discounting it; it's simply orthogonal to the story. We already know NSA spends huge on compute. None of us are surprised that they have a custom supercomputer contracted from IBM. So we can't derive from that revelation that they've got a viable attack on RSA-2048 --- which, by the way, if they did, would be some of the most closely held information in the world, as there is nothing on the horizon (short of QC) suggesting RSA-2048 will ever fall.

If they had a break on RSA, that would be the story!
I understand that certain issues can get our temperature up, but that doesn't give us permission to violate the guidelines by posting like this. Please don't.

https://news.ycombinator.com/newsguidelines.html