skysight-inc/HackerNews huggingface dataset:
I think even 3 years is a little problematic. What are you supposed to do, take care of your child until they're 3 years old and then just go back to work?

Every company should be legally obligated to provide 18 years of paid leave for each child a worker has. Anything less is signaling that they value money over the personal and family life of their employees, and it's ridiculous that I still haven't found a country or business that offers this.
As exciting as this is, we already know how people have used the decreased danger of HIV infection to become careless about other types of STIs. Given that our antibiotics are losing their ability to treat many common STIs, an HIV cure without some advancement in antibiotics will be swapping one epidemic for a series of others.

Edit: I wanted to add a couple sources for my claims above. Once people stopped believing raw sex was an existential threat they started going nuts, falsely believing that everything else can just be cleared up with a pill. Let me also say that my SO worked on the front lines of public health for almost a decade so I might have a unique perspective on this issue because of what she experienced as part of her job.

http://www.cnn.com/2017/03/01/health/syphilis-newborns-partn...

http://www.huffingtonpost.com/entry/std-rates-in-the-us-rise...

http://www.ocregister.com/2017/01/26/syphilis-up-412-gonorrh...
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trade, technology or feminism

Easiest game of "one of these things is not like the other" ever! I also love the ham-fisted implication that "feminism" is a positive thing that "educated" men should aspire to.

I'm sure all the well read people on here who don't brainlessly follow herd mentality and question the status quo will think for themselves. I'm sure the HN "community" isn't a bunch of back patting glorified redditors.

Downvote away you point slaves.
I have a friend that's pretty solid programmer - been at google for 3 years. He claims he crossed $400k at the 2 year mark.

That's at least 1 case that appears to support this.
Federal Government 10-K (from USAFacts) [pdf]
Have you tried Cursive for Clojure lately? It does a lot of the things really well
It's smart, but that also struck me... this is the USA we're talking about.

I used to be able to enter that country with a driver's licence and a hello. Amazing how things have changed.
If one is familiar with the term 'CRISPR' in the first place, then the intended meaning is pretty clear.
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He is right, you could do something roughly equivalent in 1983-era C, albeit a fair amount clunkier due to the lack of partial application or (any kind of) type-checking:

#define DX (double)0.0001

double f_prime(f, x)
register double (*f)();
double x;
{
return ((*f)(x + DX) - (*f)(x)) / DX;
}
#define DERIV(F, X) f_prime((F), (double)(X))

double cube(x)
double x;
{
return x * x * x;
}
#define DERIV_CUBE(X) DERIV(cube,(X))

main()
{
printf("%f\n%f\n%f\n", DERIV_CUBE(2), DERIV_CUBE(3), DERIV_CUBE(4));
}
> What makes it a PaaS is that it integrates Jenkins

Not just Jenkins. There is a Jenkins button and you can use Jenkins for CI/CD, but you can define BuildConfig and ImageStream through their point-and-click interface without ever adding Jenkins or writing a line of config by hand.

You just need to use one of their built-in ImageStreams and DeploymentConfigs. I got my first exposure to OpenShift through the Developer Preview/OpenShift Console beta. At the time I was testing it out, deployment of Jenkins was outright broken, but I was able to get my app working and builds automatically generated in response to GitHub webhooks (eg, CD without Jenkins.)

The Developer Preview was a very interesting experience, and their support people were quite responsive in #openshift-dev, but I'm giving them some latitude in that it was clearly labeled as Preview / Beta and a totally free product with built-in expiration date.

I would not have been likely to call it a good experience except that it was clearly labeled beta. But if it says Beta on the tin, and I am able to complain until it works, that's about where I set the bar for good experience. It was a good beta experience.

If I had to guess, OpenShift.io is the next phase of this:

https://console.preview.openshift.com/console/

(I am certain that you will not need to use OpenShift.io online IDE to get "batteries included" OpenShift from RedHat.)
> And Haskell particularly comes with so many syntax quirks

Wouldn't agree per se, I'd rather formulate "it gives the user-land a lot of freedom & powers for introducing syntax quirks". You can code super-clean Haskell, or you can roll in 2 dozen language extensions and libraries with a 100+ custom operators, and use TemplateHaskell --- then yeah the syntax will begin to look horribly "quirky". Many practitioners end up limiting themselves in this regard after a while, or insist on "going back to basics" as much as feasible
i think the answer is simply that most of america is very far inland, and seafood is best fresh -- especially if one is especially sensitive to the 'fishy' taste it acquires after about a day or two, even frozen. every coastal community i've ever spent time in has a plethora of seafood restaurants, though i'm not sure if this extends to grocery stores.
Please don't post like this to HN. It's a breach of the civility rule to accuse a fellow user of "standard PR stuff" and insinuate astroturfing or other bad-faith behavior without evidence. The overwhelming majority of the time, you're simply talking to someone with a different point of view than yours, and that's the foundation of civil discourse.
Even with the CPU, you also need the right chipset and the right firmware to actually light this stuff up. While especially in the laptop sector there are consumer devices that include this, it's far from universal.
That was the plan from the start, no? I was pretty disappointed to learn that most drug research is essentially mass testing all kinds of molecular agents that happen to show some beneficial effect for a problem at hand. It seems just too simple a method.
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I have a cheap Windows 2-in-1 that lists for $180 but I picked up for $100.

I'm reasonably happy with it, except for the touchpad (planning to get a mouse and disable), but for the price it's certainly a fine computer. It's definitely what I'd buy for a kid.

I expect that MS is just encouraging more of those kinds of devices to be made, maybe with slightly better HW.
Startup School 8: Jan Koum of WhatsApp
Azul Systems releases Falcon, a major Java compiler upgrade
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I mostly agree with your post, but I would suggest refraining from accusing others of a "condescending tone" when it's unclear, at least when it's not blatant. I think you're getting downvotes because you seem overly defensive.

He appears to have accepted your statement without hostility and provided a fair reply. Please be careful not to interpret the lack of a pandering tone or excessive niceties as condescension. Remember, project runners hear complaints all day every day, they're never going to be able to make everyone happy, and this is a technical audience.
This resonates with HN article this week end talking about a lot of recent startups simply being centralizing rent seekers. The Saveur article shows that an "end to end" model can be cheaper, at least for a specific solution point (to whit: get it fresh, cook, don't worry so much about the cleanliness of the rind). While the centralized solution that serves most grocery stores costs more and promotes boring sameness.

Sometimes I want that sameness, but as the economy, or the Internet architecture for that matter, centralizes around a few corporations you end up with a bland world.
You can't have effective competition without density and an ability to start extremely small.

This is a good metaphor for Net Neutrality. Maybe most of the US doesn't understand Net Neutrality, because they are trapped in their strip-mall big-box store hell, and don't know about real free markets IRL.
Every Planet Earth episode has a mini-"making of" at the end of it which usually shows how shots were acquired.
Sushi is quite popular with the Chinese, both in the states with ABCs as well as in the mainland.

See this article for one datapoint: http://www.worldfishing.net/news101/Comment/analysis/norway-...
Last time I read about CRISPR used to remove HIV from infected cells, the virus mutated to defeat the CRISPR attack - could this happen here?
The GOP really are the best a double speak.
Only if we fail to educate people about the dangers of other STIs.
> Reproducibility is a big problem in analytic pipelines, specifically genomics... [Docker solves this problem].

There is a legitimate fundamental issue with reproducing people's setups and Docker solves this. Ergo docker is valuable technology for data science.

Literally typing `docker run...` to reproduce results (vs. VM setup, installation etc.) seems important enough to justify their phrasing.

Fact: there are handfuls of data science startups that essentially rebrand docker and have been funded in the hundreds of millions of dollars specifically to solve this problem.
With you on the 1-pin's so fiddly and often impossible to make out once you have the board in and your hands are in there, I've started taking a sharp picture of them and then having that on my phone so I can can count in and down.

Also yes why the hell is that that not a standard.
Interesting point. Is that basically the same problem NIF has albeit in a different medium?
I wonder if they make a distinction between taking a speaking gig for money, and speaking on behalf of the company (i.e. traveling on the company dime and getting paid by the company whilst speaking)?
Because it's creepy.

More specifically: it explicitly attempts to address a particular mental and psychological states (in particular, states associated with anxiety and the need for approval from others) rather than an economic activity (like "needs a car").

Yes, car ads (and all kind of ads) have implicitly been designed to work off feelings of anxiety (and the need to fit i), since the beginning of time. But it's the all-out brazenness off this effort (combined with the fact that, again, it was explicitly designed to target teenagers) that pushes it over the edge, in my view -- and well into the terrain of Creepy.
Seven robots you need to know
Imo, the biggest multiplier is good management.

The 10x developer existing means that the field is not really competitive yet and/or there is mismatch between who is trying to work there and what the actual needed aptitude is. Well managed company should facilitter knowledge transfer between people and competitive field should have large enough supply of people (unless the hiring process sux for some reason).
The "jolt" when opening the app was a nice touch!
Since sushi is Japanese, doesn't it make sense that it would be found in Little Tokyo instead of Chinatown? Maybe there are lots of Chinese people eating it outside of Chinatown?
Different markets.

My local grocery store probably has 150 ft of cooler space devoted to beer. About half is Budweiser, Miller, and other huge brands, the rest is from smaller brewers, many of which are local. How does the selection compare at the local Lulu Hypermart?
Maybe we could store the translation of shortcode -> full URL on the blockchain
If I can run Linux on it, then maybe.
Wow, I had not connected the idea of using CRISPR genome editing with targeting virus dna segments. If I understand the technique correctly (and I am not a biologist for sure!) they used an adeno virus modified with a specific Cas9 setup to elide HIV DNA from cells it infected (normally I associate viruses with adding DNA rather than removing it :-)

Is that even close to a correct interpretation? It sounds like the technique could be used for pretty much any virus dna you wanted to target.
Cheap and abundant energy was already promised with nuclear and didn't happen. What makes you think that renewables will become "too cheap to meter"?
It's awesome that this is possible. Right now HIV infections are basically a minor nuisance, provided you're taking the appropriate medication, but this bodes well for future treatment of viral infections.
Well, it's very useful, and in continue development.

In the end you have to know what you are doing, but it will point you to very useful tips and show some warnings that you can look to improve the security of you server. But in this, I still don't know two SysAdmins that concur on the best way to harden a server. There is a lot of things to consider and there are very strong opinions on how to do certain things.

But without doubt, it's a very useful tool, even if you know what you are doing you can use it like a checklist to know if you are forgetting something. It's not perfect (nothing is, and less in this field) but I can only recommend it.
> merely $2B in profits last year

I've never seen billions of dollars in profits dismissed so casually.

>ISPs have terrible customer service because most of their efforts are going into keeping those wires and fibres intact.

ISP's in other countries, even ones of similar scale to the US, don't have to chose between quality customer service and quality internet service. To call your argument facile would be overly generous.
Slightly related but very cool, there's a British photographer Tim Flach who takes photos of animals in his studio [0], they are openly taken in a studio and it takes nothing away from their beauty.

[0]: http://timflach.com/work/more-than-human/
Quantifying Startup Funding Inequality for Fun and Profit
> People in the US tend to prefer fish that's already bland to begin with (cod, haddock, tilapia, and sometimes tuna or salmon)

To be fair, in the Midwest this is often because there used to be a diet of much more flavorful freshwater fish from local lakes, but overfishing destroyed their populations and pushed prices way up, forcing cuisine to adapt to cheap saltwater fish.
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This is, in fact, exactly why CRISPR evolved.
This, coupled with immunotherapy which boosts efficacy of our own defense mechanisms - for example, NK cell doping via LY49D/DAP12 - is quite exciting.

As someone else noted, THIS is what CRISPR was evolved to do. It was a DNA-based immune system used by bacteria to explicitly identify an invading virus via DNA, and to store a record of previously unknown virus for future reference. And, it was intended to function continually, in a living organism.
I don't think this study was the one that triggered regulatory action. For one thing, this particular study seems to have been published in late June 2016. But U.S. regulatory action took place well before that:

http://www.cnn.com/2015/12/30/health/obama-bans-microbeads/
I can, see you took my statement of "works" to mean they could explain to you why the Higgs field allows particles to have mass and then extrapolate that up to explain the existence of a TV. I simply meant they know how to use it for its desired purpose, better then most adults do.
The epicycle theory was actually pretty good and explained planet motion to the precision that measurements of that time provided.
> As long as me and my ops team are the primary people with skin in the game (read: getting 3AM wakeup calls), me and my team will maintain a say in what tech stack we're responsible for the care and feeding of. The days of dev throwing code over the wall to ops is long gone.

Here's where we're in violent agreement. I believe the best way to ensure that the pager doesn't go off at 2am is to give that duty to developers. Far and away the most likely reason for a production issue is new code that went live. No matter how good communication is within an organization, ops will never have the same context for issues like this that dev will. So dev being the tip of the spear with regard to incident response will result in faster resolution. The job of ops is to be an enabler of this responsibility. They should be building tooling and infrastructure that makes it easy for dev to do the right thing but doesn't force decisions on dev. Ops is an abstraction layer that gives developers higher-level primitives for infrastructure that allows them to solve the customer problems more easily.

But there's no substitute for the dual benefit that you get from a) oh...I wonder if this problem is related to that change I reviewed yesterday and b) hmm...I've got pager duty this weekend, so perhaps I shouldn't just LGTM this PR. And for that reason, developers and developers alone are responsible for a working application. Ops is only there for support.
And in the absence of computers (or any other tool to stimulate their curiosity; computers are just an excellent tool), the "special" (I hate that word) kids will just be miserable. If 90% of the kids who are given one of these computers squander them and 10% of kids use them to find an outlet for their curiosity, then it's worth it.

Unless you actively try to stimulate the smarter kids and give them something to sink their teeth into, it's extremely difficult to tell the difference between kids who are bored and miserable because the material is below their level and kids who just don't give a shit about learning. In both cases, they'll be goofing off, not paying attention, and possibly disrupting class, but one group can flourish under the right conditions, and the other group is a lost cause.
It is worth noting that the real challenge in gene therapy at this time is not editing the genes, but in getting sufficient coverage of edited cells (and especially progenitors and stem cells) in an adult individual to achieve the therapeutic goal and make it last.

(Most studies of genetic alterations in the broader sense have bypassed this challenge by working with animal lineages, or animals in which the editing happens in the earliest stages of development, when there are very few cells needing to be changed. The alteration then propagates during embryonic and later development).

There have been a number of very promising studies in the past year or two with regard to gene therapies to apply to adults, such as animal studies that demonstrated a cure for an inherited muscular dystrophy, but in the bigger picture, comprehensive coverage of tissues and cells is still something that the research community is in the midst of getting to grips with.
"animal models" is obviously a term of art but what does it mean in plain English?
So, why are the same folks trash-talking Basecamp for not offering more paid leave, since the US has no such subsidies? Aren't they based in the US?

I'm not opposed to such subsidies being implemented in the US.
Yes, it sounds like the approaches may be slightly different. My wife has needed ambulance care on several occasions due to an ongoing medical issue, so I've got to know the teams pretty well and one of the cops told me that whenever a male calls an ambulance for a female in my county the 911 dispatcher is instructed to assume domestic violence is involved and send the police as the advance party. I think our house has been flagged as "safe" now, as even though the cops still turn up it feels like more of a tick-the-box exercise these days and they no longer come to the door with their hands on their holsters.
You might get something out of this article: http://www.americanteeth.org/2015/06/21/why-i-m-a-capitalist...

If "Capitalism in America means as close to monopolization and price gouging as possible." is your definition of capitalism, then you're off. (And I think that may be why you're being disagreed/downvoted on.) If you think that monopolization and price gouging is an emergent property of capitalism in America-- well, then, I wanna see some citations.

My (radical, libertarian) view that a free market would only leads to monopolies when they're _market monopolies_-- meaning they've already providing the best service, and will continue to do so. The really damaging monopolies only ever come from government-granted powers. https://www.youtube.com/watch?v=4Vw6uF2LdZw
> Right now HIV infections are basically a minor nuisance, provided you're taking the appropriate medication

Even with your caveat, the fact that more than 1 million people died from HIV in 2015 is probably a good signal to not use the term "minor nuisance".

https://www.cdc.gov/hiv/basics/statistics.html
If your child is dying and I have a medicine that can save him but my price is that you hand over your life's savings and become a slave in my salt mines for the rest of your life, and you do it because you don't want your kid to die, was it worth it? Or is there something else going on?

ISPs are a cartel protected by corrupt politicians. Let's sort that out before we start claiming that the free market is working and these services are priced appropriately and fairly.
Isn't the power production inside the sun on the order of 300 W/m3? Is it at all reasonable to think we could scale this process to 0.1-100 MW/m3, to become economically viable?
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I really wish that we as a society would spend less time sitting around figuring out who to blame for shit and actually invest in the things we claim to care about. I am sick to the back teeth of bullshit free market ideologies that have an extremely poor track record in reality.

That does not mean I am opposed to or deny the value of markets.
The Google Pixel C runs using the Nouveau open-source drivers.
I think this has to do with the type of fish typically used in western cuisine, which is heavily biased to larger fish that can be cooked as filets or have less bones.

Asian cuisine makes much greater use of smaller fish that are oftentimes cooked whole, so the range of options tends to be larger as well.
According to RMS [1], even the secretaries in Bernie Greenberg's office were extending Emacs in Emacs Lisp. Nobody had told them what they were doing was programming and they were able to pick it up from a manual.

The parentheses can't be that big an obstacle.

[1] https://www.gnu.org/gnu/rms-lisp.en.html
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This laptop is awesome! I hope they will update the removable dynamic hinge model as well, I really liked it.

I do have some concern that Windows S may be another step towards the "boiling the frogs" that Tim Sweeney was warning about. I think he is very wise in saying we should be wary of Microsoft gradually closing Windows down as a platform.
I'm OK with these kinds of quirky add-on allowances so long as the category for the add-on is positive, either for you as a person (e.g.: fitness, learning) or the local community (e.g.: paid time off volunteering, charity matching). We'd all be better off if we were a little more involved with our community, a little more active, and eating a little bit healthier, and the most common excuse for not doing these is "I don't have the time/money." If you just give extra cash how can you achieve the same effect in encouraging people to live healthier?
Correct. You can also use CRISPR to edit a person's own cells in a lab for injection back into the person's body to combat a slew of diseases, including cancer.

China is already experimenting on live humans: http://gizmodo.com/china-is-racing-ahead-of-the-us-in-the-qu...