skysight-inc/HackerNews huggingface dataset:
There can be a real benefit to isomer drugs. They get prescribed way more than they need to, no question, but that doesn't make them entirely useless.

For example, desvenlafaxine (Pristiq) is the R-isomer of venlafaxine (Effexor). You'd think it would be a useless me-too drug, but in fact it's metabolized differently, which affects people with CYP450 mutations. Ultrarapid metabolizers will end up with way too little Effexor in their system, whereas Pristiq will work fine for them. Other way around with poor metabolizers: they don't metabolize Effexor well enough, so they'll get worse side effects. (See http://psychopharmacologyinstitute.com/antidepressants/snris... and specifically http://psychopharmacologyinstitute.com/wp-content/uploads/12...)

Ideally we'd all know our CYP450 profile, or our doctors would, so they could prescribe older and cheaper drugs when they work well enough, and save the new expensive stuff for patients who need it. Maybe someday medicine will come around to using the tools it already has at hand. Sigh.
You can use systemd or docker with JupyterHub, and make it as protected (or not) as you want. We could also write a spawner that spawns full fledged VMs, which would give you 'real' untrusted isolation - would that be something interesting to you?
We were doing this with a team of sometimes one or two reliability engineers, but we were cheating, because our company culture meant that the engineers who built the systems are responsible for keeping them running, so they would invest their engineering time in fixing the problems along with us.

I personally found that runbooks were even worse for small size teams (like our four person reddit team) because they would get out of data even quicker than at the bigger places due to the rapidly changing environment.

I wrote down thread that if all of your deployment is automated than it is much easier to automate remediation, because you just change your deployment to fix the problem, as long as you can redeploy quickly.
Self-Assembling Microchips May Be a Reality Soon
Stephen Cook, Micali, Goldwasser, Rabin, Scott, Karp, Hartmanis, Stearns, Manuel Blum, Yao and Valiant. These are all pure theoreticians; I didn't include data structures people and applied-ish cryptographers like RSA and DH.

More than a significant fraction of Turing awards have been won by theoreticians.
Help build Urbit.
Only rich people can afford the rent in locations that are convenient by non-car modes. The poorest drive the farthest because that's where housing is affordable for them.
I mean, (1) has nothing to do with the Sun examples, it's not something unfortunate about CDDL but unfortunate about the GPL. If one thinks of it in national terms: there is a GPL Nation holding its land against a bunch of proprietary city-states; a huge swath of land is occupied by the neutral space of MIT and BSD, people who have no real national identity and GPL is fine with them, "Can you be press-ganged into our army? Yes? Great!". And then there's these strange lands MPL and CDDL which lie close to GPL; they culturally agree with GPL in many ways; they like copyleft and want their works to remain free... but they intentionally have a separate national identity because of practical and historical reasons (at some point they had trade deals with some proprietary city-states). And it's just unfortunate that the GPL does not allow for any collaboration anymore, because "if you have any national identity, that is against our nation's constitution and we cannot work together with you." Meanwhile all of these little nations can work with each other just fine, can work with the proprietary city-states just fine.

Regarding (2), the history is a bit murky. Danese Cooper wrote the CDDL and has said that GPL incompatibility was intentional; but several others have come forth (both at the talk that he said that, like Phipps, and since then, like Cantrill) to say that it was not a design goal at all, it was in fact a compromise between engineers who wanted an MIT/BSD license and management who wanted a GPL license.

The true story seems to be: Engineers were very firm about "if you force people to jump through the Purity Hoops to install proprietary drivers you are increasing the total quotient of worldsuck for generations to come and frankly, why the hell are we opening this system if we're going to make the world suck more." Meanwhile management was very firm about "we worked so unbelievably hard to open this thing up, we don't want some big player like IBM to just fork off a proprietary version, spend a big budget to become the big player in the Solaris game, and then all of our work open-sourcing this damn thing was for nothing." The CDDL was a clean-up of the Mozilla Public License which sensitively addresses both issues, it deliberately contains a big honking wall which is (and everything inside of it is) copyleft open-source, but the license has no problem being distributed with proprietary add-ons as long as the interfaces they use, baked into the copyleft open-source wall as they are, follow the copyleft open-source license of the wall and everything therein.
How is their denial affecting you? Has it led to tangible changes in your life? Maybe you'd argue that it has led to a lack of tangible changes, but I don't think you can stand on that. Environmentally conscious efforts have continued to grow year after year despite a lack of political consensus, ultimately leading to solar now being cheaper than coal. That isn't due to regulation. It's because people who care have found ways to make a living doing the thing they care about and making it more viable.

tl;dr: People may deny the problem, but when the solution isn't political in the first place, I can't see why it matters.
Depending on the era, typically it was a full retreat and slaughter as soon as the shield wall broke. Not all the time, but that was just typically how it went.

Charging cavalry would be stupid. Soldiers knew no horse would challenge a bristling shield wall.
I've been getting derailed into a game project based on Minecraft 1.11:
http://www.airwindows.com/snowball-madness/
https://github.com/airwindows/SnowballMadness

Maybe it's lame but I like using that system to experiment with what happens in gameplay, especially in an anarchistic mode where it's the system itself that copes with entropy. Been playing with this particular toyset for a few years now. The main feature is making available to players, VERY destructive features on a persistent server. You can fire infinite TNT artillery just off the hotbar, 'multipliers', pickaxes that remove terrain outright, very nasty semi-tame mobs: the idea is to take lots of 'hacked client griefer' behaviors and build them into the game in still grander forms.

Then the trick is, how do you resist entropy and allow for any sort of constructive use? I came up with a system where the server (on unloading chunks) checks for a diamond block at the very center of a region. If it doesn't find one, it marks the region for deletion on restart, which regenerates the area. The idea is that there will be random destruction, but some of it will revert to normal: and you can't necessarily tell the difference between normal, and protected/built on, in just surface gameplay.

A lot of the coding addresses challenges the plugin makes possible in the first place: for instance, placing a giant sphere of fire is one thing, but then if you multiply that times 16 times 16 per shot and begin spamming the multiplied fire spheres, it's pretty obvious the server will grind to a halt. So it turned into a more sparse placement, with a special 'fire spread' handler to make spread die off a lot quicker so the server crunch would only be a minute or so.

Next, since there's the capacity to empty water with an empty bucket, it seems like a good idea to make an 'ocean filler' that fills back up areas that were emptied. Seems like there is always a new concept to play with :)

Previous experiments showed me how easy it is to just get swamped in toys and effects, so at some point it really became a 'generalize effects to create a logical discoverable system' project…
They have world's top engineers, designers and dollars! And they use reporters send out an apology. Can't even do it directly to its users/fans. Reading the content it feels like a damage control PR.

Apple has lost its way. Their support has become horrible if not arrogant. Their updates keep bricking devices more often than not. Their hardware fails more than it used to.

If they thought the Mac Pro was a mistake, how is the MacBook Pro a success?

Can't innovate anymore, my arse, you bet you can't!
DHS considering revising H4 EAD
I'd say it's more the timid VCs and investment community at large. Our startup finally gave up on Canadian investors and went to New York for money.

Fix that, and startups will flourish.
Problem: coordinating weekly carpools with N > 2 drivers

Solutions: https://beta.snapridesapp.com, React/iOS/Firebase app to basically coordinate user provision, group membership, schedule, calendar synch & email/push/sms notifications. Had two weeks between gigs to port to Firebase; so far so good, waiting on Apple to approve and push the update.
If you really want to geek out about F1 (which is incredibly fascinating from a rules and sheer technical wizardry perspective), I would highly recommend the F1 Technical forum.

https://www.f1technical.net/forum/
Prepping notes before I dive in to redraft and finalize Ghost Engine, my new space opera for July 2018 (UK publisher will be Orbit; US publisher TBA).

Also working on a Wild Cards short story for George R. R. Martin, and awaiting the copy edits on Dark State, the second Empire Games book (publication scheduled for January 2018, by Tor).

And in the queue behind that, is the scheduled final rewrite of Empire Games book 3, Invisible Sun (due for publication in January 2019, from Tor).

This should keep me busy through to the end of the year!
That's going to hurt a lot of folks. Especially those whose manufacturers are not doing their bit with respect to updates. It's absolutely incredible to me how sloppy manufacturers are when it comes to keeping phones updated, they seem to see phones that are older than two years as effectively end-of-life.

Even Google is guilty of this, though to a slightly lesser extent.

See: http://www.androidpolice.com/2016/06/21/google-support-site-...

So three years or 18 months past sale.

Personally I think that a phone is only end-of-life when it stops to work and that manufacturers should either offer to buy them back if they don't want to support them any longer or should be forced to provide security updates.
For a moment my brain read "Tim Berners-Lee wins Turing Complete" LOL
Why are you saying this? We're talking about good AI and you say yourself

>The AI was a joke

I don't understand how I should take your comment here? Are you agreeing that other than half life, there are no good single player AIs?
Released yesterday. I hadn't gotten any update prompt yet. I'm guessing the (vast?) majority of iOS users haven't upgraded yet.
Quote:

Based on the current version of the Handbook, the fact that a person may be employed as a
computer programmer and may use information technology skills and knowledge to help an
enterprise achieve its goals in the course of his or her job is not sufficient to establish the position
as a specialty occupation. Thus, a petitioner may not rely solely on the Handbook to meet its
burden when seeking to sponsor a beneficiary for a computer programmer position. Instead, a
petitioner must provide other evidence to establish that the particular position is one in a
specialty occupation as defined by 8 CFR 214.2(h)(4)(ii) that also meets one of the criteria at PM-602-0142: Rescission of the December 22, 2000 “Guidance memo on H1B computer related
positions”
Did Japan elect a lunatic that wanted to roll back all the institutions put in place in the last sixty years?
At this point I admit I'm way beyond my depth.

This article seems to imply a correlation between the fish operator (<=<) and composition. Specifically his section on Kleisli monad.

http://www.haskellforall.com/2012/08/the-category-design-pat...

But I don't know the space well enough to know if that's answering your question.
ReadCoor| Software Robotics Engineer - Systems | Cambridge, MA | Full-time, ONSITE | www.readcoor.com/careers

ReadCoor, Inc. is seeking a talented software / robotics engineer to contribute to the development of our cutting edge, three-dimensional sequencing devices. We design and build fully integrated systems that employ state-of-the-art motion control, nanoliter-precision fluidics, high-power laser illumination, and sophisticated imaging modalities to spatial map and sequence complex biological samples. As part of the Engineering R&D team, you will play a pivotal role in the design and implementation of the control system architecture that drives these advanced robotics platforms.

Responsibilities

The ReadCoor R&D team is a dynamic group of engineers and biomedical scientists with deep experience in biotechnology platform development. Team members work cross-functionally to develop the foundational technologies behind our work on artificial neural networks, gene therapies, and emerging infectious disease detection. Your role will primarily focus on architecting the sophisticated robotic control systems and advanced signal processing software that powers our sequencing systems. You will collaborate with a cross-functional team of engineers to develop custom solutions that allow us to push the limits of multi-dimensional motion control and ultra-high-throughput image acquisition.

Health, dental, and vision benefits. Unlimited vacation. 401K and flexible work.
Process: phone screen - tech screen - tech interview - offer.
To get in touch: readcoor.com/careers
Documentation is the only defense against tribal knowledge. If your turnover is low, you might not notice this, but that doesn't mean that it isn't biting you.

Not all processes can be automated today. Some can only be automated tomorrow. Some can only be automated after some blocking functionality is added. Documentation is how you plan your automation.
There's a fair bit of AI, NLP, etc. The system starts out with decision trees built by/evaluated by medical professionals and learns what conversational elements are required to reach a diagnosis. This isn't just a trivial set of hand-built trees.
It's always a gentle glide until a mountain shows up and then you crater into it.
You were using it wrong.

I spend much of my OS X time in terminal.
I also find this fascinating. I just signed up..ryan@recraigslist.com I also have another use case I'd like to bounce off you if you could shoot me an email. Thanks!
I will not provide an exhaustive list, but I will give a single example.

I also wish I had the source code to the controller software to a large motorized rock climbing wall that was produced back in 2002. The "Assent fun rock".

Alas, I don't. So... I've reverse engineered the protocol between the device and the native computer controller and implemented my own controller stack from the ground up on linux.

Why? because I wanted to add an algorithm that lets the speed of the device respond to the reading on my heart rate monitor.

Here's a photo of me on the thing, courtesy of my friend.
https://www.instagram.com/p/48WVcbkT6x/
I've recently launched https://reservv.com a platform for facilitating online appointment booking. Not the first to try and tackle the problem but I'm trying to make the UX simpler and the whole process better for both sides.
In general I agree with you that a technological breakthrough is the only thing that will really help us and that government cooperation will be hard to come by but I do think that lobbying for carbon taxes could help move the needle on how much effort is put into research.
I recently posted about why I dislike Rails. For a long time, I also disliked Django, for somewhat similar reasons. [0]

The biggest thing that I disliked about Django was its templating system. Its attempts to magically render values were (and are) offensive. When I looked before, just like Rails, it was take it or leave it, and there was little sympathy for making it pluggable.

Such issues, and the culture's Rails-like resistance to outside suggestion and interoperability, pushed me into Pylons/Pyramid.

Today, I think Django has improved a lot, and I don't think it's fair to continue to lay the pox of being "Rails-for-Python" on it.

Django now supports third-party templating engines (so the dealkiller is gone) and last I checked, the SQLAlchemy integration, while not official, is much better. They now have Python 3 support and as pointed out here, will be going Python 3 exclusive soon.

I've submitted a few bugs and they get triaged quickly. I had a patch or two merged. Pretty happy with that. The Mezzanine guy is also great about this stuff.

Django does follow the old-school big magic model, but I haven't encountered much [recent] trouble in working around that. The community does not seem to respond negatively to such suggestions anymore.

People say it comes down to Ruby v. Python, and I think that's true, but in a different way than most. It comes down to the core culture of Ruby v. Python.

As the MVC framework hype and subsequent noob-influx died down, Django was left with the core Python community of mature hackers who've developed a refined palette for simplicity. This has been Django's biggest asset, and has turned it into something that's worth using today.

Disclaimer here: I was not then, and I am not now, super deeply involved in Django, either the product or the community. This is primarily based on my impressions from light observation and use. Some/much of it could be wrong.

[0] https://news.ycombinator.com/item?id=14015270
In my opinion, there is a gap between what you can learn on an Arduino type environment and a Raspberry Pi type environment. When I started using Cortex-M level processors (32 bit, very simple MMU (protection only) I realized that it could be the basis for a "PC/AT" type system where you could explore everything from a simple monitor based operating environment (think MS-DOS or AmigaDOS like) through to a self hosted set of compilation tools. The hardware is pretty easy (there are lots of different ideas in this space) but the curriculum is currently still a bit weak. So with the addition of a simple FPGA based frame buffer I've been building a system that can be used to teach a student computer systems.
No not really cause i said nothing about a society that doesent know what pluto looks like these are your own strawmen.
How Russian Twitter Bots Pumped Out Fake News During the 2016 Election
You might find Ethereum's Whisper messaging protocol interesting.

https://github.com/ethereum/wiki/wiki/Whisper
> What is your source material for automated diagnosis? i.e., how was it trained?

Incident reviews. If something happened that wasn't covered, then it is added as an outcome of the incident review.

> Are there cases where an automated diagnosis could not be made for an incident and if so was manual recourse possible?

For sure. Manual recourse was to dig in and figure it out either with the command line or the monitoring system or whatever else.

> How would you retrain the 'diagnosing app' to handle the new case?

In most cases the "diagnosing app" was a dashboard on the monitoring system, with a set of relevant graphs, so you would add a new graph. There was also a tool that correlated graphs, so you could add a new graph and correlation.
The Phony Internet Privacy Panic (paywall)
I'm building a very opinionated iOS app for learning Spanish. It teaches primarily by ear and in context (rich conversations). http://supercocoapp.com
I'd love to hear your thoughts on how those issue can be solved that doesn't involve totalitarianism or in other ways infringing on people's rights. Because the problem you're trying to solve has been attempted by many murderous dictators in the past. "But this time is different," they all say, and it never is.
I've enjoyed 5 of his other books: Mars trilogy, 2312, and Aurora (Aurora I enjoyed so much I've read it twice).

But I'm struggling with 2140 (just checked and I'm 41% of the way through). Despite living in New York and having a lot of fun with the description of a venetian New York it's just not grabbing my interest yet. I'm going to keep plodding through it but at this stage I'd rather just start re-reading Red Mars again.
Project: I've built a small app that assists in efficient, timecoded note taking, like "03:25 - doesn't recognise the download button (unhappy)"

Problem: when doing interviews and usability tests/walkthroughs, it's hard to keep track of time, take notes, observe the persons emotions and have it in sync for reviewing the recording later.
Interested as well for full stack positions. Thanks for sharing!
Moom is pretty good, beats the crap out of Windows.
What fresh hell is this?
Intel Security is McAfee again
I'd be fine with AMD kit if Apple helped make OpenCL a first-class citizen.

For the dev segment, I hope they look at Homebrew stats and not just regular XCode users.
3 Things Millennials Are Looking for in a Company
I suspect machine learning (and other, older ai techniques) might work for games - but one would probably have to train them for the right goal: fun.

I suppose for some players and some games, it makes sense to train for "good" - but even with chess - is it really fun to play an ai you cannot realistically beat - ever?
Once Flatpak becomes more commonplace, the problem of distributing third-party software is hopefully solved on Linux distros.
This is indeed related. See the section on polynomial regression!
Just FYI, I run Linux mostly fine on my Macbook Pro.
Satori: Transforming the World with Live Data
hi, I am working on something similar with https://samosasnearme.com.

I am unable to sign in to your website using FB.
Not really. We have a legal agreement, and then the users state their chief complaint. We record their symptoms as we ask them questions and produce a list of possible conditions along with their disposition (e.g., Go see a doctor in 24 hours, visit an emergency room, home care, etc.) based partially on the Schmitt-Thompson protocol. Schmitt-Thompson is the current battle-tested standard for medical triage.
lololololol

It will be $500 more expensive since "pro" users can afford it.
Tanis! OMG Tanis. Found it through a recommendation from Reply All (which is also great). It's a serialized docudrama about mystery, conspiracy, mythology, so much. Give it a shot, it'll hook you.
iOS 10.3.1 and above fixed this.
Given that skyscrapers seem to describe buildings of 40+ floors, losing 3 is less than 10% of the total floors, possibly a little more of the total floor space given that upper floors may not have the same dimensions, offset by possibly fewer elevator shafts beyond certain points. If the bottom can be retrofitted to be very secure in water (extra concrete?), then I don't see why you would abandon it. It's not like you're constructing a whole new building and have to forego three floors, it's already existing and it's just a matter of putting the work in to make sure it's still usable.

These things are all anchored into bedrock anyway, so it's not like you should have to worry about the material under the foundations shifting or eroding.
Yes, in a big (in area) city, poor people mostly can not afford to live near work and must move by car/bus.
Why Trump Lies
Working on an embeddable programming language (think Lua, ChaiScript, etc. use-cases) with simple yet powerful syntax, NO null pointers, static typing, and memory management WITHOUT A GARBAGE COLLECTOR (XD). It's not ready for public eyes yet, but you can follow the details on the official blog:
http://copperlang.wordpress.com
Most users don't realize how good Apple monitors are, and how much better they make your work day.

I just don't understand scrimping on something you will spend all day staring at. Getting something "almost as good" for half the price is a terrible deal.