skysight-inc/HackerNews huggingface dataset:
Martin Shkreli gouged on off-patent medicine. Pretending patents are the problem is short sighted.

>It costs a quarter to manufacture each pill but the manufacturers charge several dollars for that pill.

Is Trump writing checks to pay for R&D, salaries, etc? Of course they cost more than are to manufacture, that's the basics of business.

Unless we move to a heavily regulated single-payer system then these problems will continue. SP will negotiate with drug companies from a powerful position and be able to push down costs via policy. We keep seeing success with SP and socialized healthcare in Europe and elsewhere and somehow keep pretending the problem is too much regulation (?) or patents. Yet somehow Europe manages to thrive with those very same issues!

>We have evidence that the FDA errs too conservatively

The FDA has had public whistleblowers to stop dangerous drugs from getting approved. Its extremely arguable whether the FDA is either too conservative or too liberal or easily gamed by political pressure.
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A Facial Recognition App Using React-Native, AWS Rekognition, and Polly
Show HN: I built a fully ReactJS/Redux WPAPI theme
Given a glance at the mental health medications I see, reduced time to market is the last thing that would help.

I don't believe Western Europe is any better in quality of drug vetting.
And we expect Chrome 57 to ship Grid (which should ship around March 14th), Safari 10.1 (part of macOS 10.12.4 and iOS 10.3, expected March/April), and Edge to probably ship it later this year.
Show HN: Do a Good Deed a Day for a Co-Worker: Now on Slack
To spell it out, that's < 12.7 megabytes every 24 hours. If there are 10 million Echo devices, that's 127 million megabytes a day, or 127 terabytes a day. That's actually not that hard to handle for the company that runs AWS, so while extremely unlikely, it's not impossible. Just very, very costly.
Unfortunately, this is a line that Wikileaks themselves are running with: https://twitter.com/wikileaks/status/839120909625606152
In UK government has almost a monopoly for buying drugs, so they have a leverage in negotiation and there is a lower overhead with paper work.

Americans subsidize drugs for the rest of the world.
They changed the tweet which I guess is factually correct but still misleading.
I wouldnt be surprised if the zoo had terrible security and no cameras. The poachers left a second horn behind because they were supposedly scared off.
Running misinformation is part of Wikileaks' job. It's not the NYT's job.
The US pays an unfair burden to cover the cost of developing new drugs. That said, many drug companies seem more concerned with selling drugs that are barely better than a placebo and have cut back on research efforts.
Okay, well. Will MSDN subscribers get iso's eventually?

It seems also to be broken, or your servers are choked :-(
> The US chemical weapons program is downright frightening.

Was: they committed to destroying those weapons, and have been doing so for 24 years. They were 89.75% complete in 2012. The video you linked was from 1973.

https://en.wikipedia.org/wiki/United_States_chemical_weapons...
I live in DC, and have a bunch of friends in common with Seth. The crowd of tinfoil-hat-wearing jackasses spreading this bullshit do nothing but continue to cause pain for his family and friends.

Y'all can hide behind your keyboards, but there are real people here. Think about them for a change.
Homeopathic refers to a specific set of products, where the "active ingredient" is diluted to the point where it is no longer present. It is literally water.

There are other types of non-standard remedies, which you might be talking about. But Homeopathic, specifically, is a synonym for water with fancy labeling.
Smokey Yunick's 7/8 '66 Chevelle is the classic NASCAR cheat story. It's on the Wikipedia page here: https://en.m.wikipedia.org/wiki/Smokey_Yunick

He basically scaled down a car's dimensions to make it lighter while still looking similarly to the full size version. This made NASCAR introduce jigs to measure the cars. A rule that is still very much in use.
There is a link to the github repo in the footer of the site.

Still a work in progress, but I was itching to go live with it.

I look forward to your thoughts.
I imagine the people who are willing to pay so much money DO actually care about buying a real rhino horn. Ground up chicken bones might be identical, but a mobster will pay for a real horn, not a bag of white powder that might or might not be a real horn.
I think you misinterpreted this article, the author claims that Uber is not violating the spirit of the law, since the spirit of the law is to promote safety, not a government run monopoly.

Given how popular Uber is, and how much people dislike the Taxi industry, it is enlightening to think about why taxi reform was never on anyone's agenda.
Well, the concept is ludicrous, and it's been refuted by studies.

So, quack quack?
Fucking awful.
The regulatory process overwhelms those incentives anyway. If you can cut down on the 8 to 10 years to market you might see more drug companies pop up chasing a long shot
(I am Greg.)

Starting something new is incredibly hard. The default is that your company never even forms, and it's on you to overcome the activation energy. I don't think I'd have the mental fortitude to stick that out alone.

In contrast, there's nothing more motivating than working with great people (and it's hard to do better than Ilya, Sam, and Elon). Everyone brings their own core strengths to the table, and if you've picked well your own efforts will be multiplied.
I learned a hell of a lot and I recognize it has opened doors for me, but the real question is what it worth it?

If you learnt even one thing from the effort, then it was worth it. Not every endeavor will bring you financial rewards, at least not directly. If you took on the effort because you loved the idea, rewards will flow via other means.
I don't trust Google, Facebook, or anyone else who provides freemium services and has ties to the American Government. I don't understand why anyone does.
Given the relatively low amount of public scrutiny/outrage/attention/fear that this death caused, wouldn't you say that the car technique would be effective? (whether or not it was used in this case)
Ask HN: Why doesn't SSH implement a 'Perfect hash function' for known hosts
I know that this is a bit paranoid, but once/if you get access to someone's computer, you're pretty much left with a catalog of other systems that you might have access to in ~/.ssh/known_hosts
My question is: why aren't those entries hashed in a way that there are no collisions? if someone wants to verify if the fingerprint is ok, there should be a command that given the domain would print the existing fingerprint (by calculating the hash meanwhile)

Ofcourse, the Hash would have to be salted (and/or peppered) by system.

*Perfect 'hash' function: https://en.wikipedia.org/wiki/Perfect_hash_function
Not for malware running in user space.
Pi and the Golden Ratio
This is absolutely correct. Plus, what they did may not be illegal per se, but we might not want them in the country. For example, I'm not aware of any U.S. law that specifically makes it illegal to have been Nazi concentration camp guard. But we don't want people like that in the country and want to deport them if they are ever found here. Hence the purpose of the immigration form.
Other users complained about this as well.
A setting will be added which will disable the animations for those that find them annoying.
Evolutionary explanations are often speculative just-so stories with no basis in actual genomic research. Nobody ran a hierarchical clustering algorithm over the human genome, inspected the dendrogram, and then found meaningful gene expressions that indicate confirmation bias somehow.

The reality is confirmation bias is probably deeply rooted in many other elements of human psychology. My (completely worthless) conjecture is that your "opinions" are deeply associated with your own sense of self-identity and self-worth, and therefore they register as very much worth protecting, regardless of external data. Opinions also often overlap with tribal affiliations, which makes them even more deeply rooted in evolved primate cooperative behavior, and therefore even more worth protecting.
I'd also like to try it without creating an account, but I understand that probably isn't going to be ideal.
You can force-enable it if you want to see for yourself whether it interferes with your Accessibility settings. https://wiki.mozilla.org/Electrolysis#Force_Enable
Sounds like you could use P2P caching to offset traffic costs.
The CIA dump apparently contains malware stolen from other countries. So perhaps if/when wikileaks starts releasing them, that'll include Russian/Chinese malware.

It may also be that they simply have far smaller security states, with fewer people who feel alarm at the extent of what's happening. Or maybe leaking to Wikileaks just isn't in vogue in those countries.
Using MS Teams at the office and I couldn't agree more. It's useful about 30% of the time. The other 70% is sharing giphies and news links.
Agreed 100% - but methinks NYT (and others) still look to them for technical guidance on some matters - however misguided that might be.
I'm inclined to agree with the premise, that "blockchain" is just what the cool kids are using, and adoption is piggybacking on that. Unfortunately the article fails to go into any detail as to why that is or is not the case, it merely quotes from the press release and then Matt points out that central banking exists.

Shipping, especially on Maersk's level, has all sorts of challenges that I'm sure I've never even contemplated, but Matt Levin's piece doesn't mention any details that leads me to think he's working off any more details than I.

Large shipping container docks are horrible environments for electronics and wireless technology. Long distances, lots of big metal things, lots of water present - large bodies of water block and bounces radio waves and salt water is corrosive to electronics, concrete everywhere, so laying cables is expensive, and there may not even be power in a lot of places. Add multiple layers of IT contracting on top of that and I'd be surprised if there's anything Internet except at the main office, miles away from everything else.

While blockchain doesn't address problems with networking technology, I can easily imagine the blockchain, as a solution for the Byzantine Generals Problem, addresses practical issues when you need to give write access to the database, to multiple parties, some of which cannot be trusted.
Why hexagons?
Mention "Signal" in any article and you'll have @tptacek running here to defend it with any costs.
> Anyone that thinks the Trump administration is going to lead the charge on reforming these agencies is foolhardy.

I think they were saying that the public (and tech community especially) will demand the reforms because they view Trump as nefarious; not that Trump & co will freely relinquish them.
Clear cutting is not a common way to harvest pulpwood, especially in North America.
I guess it should come as no surprise that the comments section for an article called “facts don’t change our minds” would be so disappointing. For me, this article — and many like it that point out how whimsical and feeble our natural, undisciplined cognitive capacities are — are a rally cry to continue the enlightenment project, as best we can and in as personal a way as we can. Years ago I learned that my family motto from way back was “through faith we are free”. I found that immediately alienating because for me it was always “through doubt we are free.”

From this article to my comment to current events:
https://www.nytimes.com/2017/02/28/opinion/the-enlightenment...
Yeah, I don't think that's too bad. If you know you're breaking the law and accept the fines and pay them willingly because it's worth the cost, I don't see a big problem with that. Where I start having trouble is when they try to hide their lawbreaking, or fight against enforcement.

For a similar example, UPS and FedEx both rack up an unbelievable amount of parking tickets in major cities for stopping their delivery vehicles in places where they're not allowed. These companies do this deliberately, because it's cheaper to pay the tickets than to have drivers take the extra time and effort of locating a legal place to stop. Some big cities have gone so far as to set up special accommodations for these companies to pay their tickets in bulk rather than dealing with each one individually. In effect, these parking tickets work as a tax on delivery companies. Doesn't seem particularly evil.

Interesting side note: USPS, as a federal agency, apparently has immunity from local laws like this, so they don't get ticketed. This gives them a substantial advantage over their non-governmental competitors in big cities.
Show HN: A counter of ToDos in Inbox
"sidestep" would probably have been a better word choice than "bypass" only because of the connotation of these words... the average person isn't going to parse these words however, sooo... <shrug> ?
To me this is much more worrying:

> As of October 2014 the CIA was also looking at infecting the vehicle control systems used by modern cars and trucks. The purpose of such control is not specified, but it would permit the CIA to engage in nearly undetectable assassinations.

https://wikileaks.org/ciav7p1/

Given the fact that car makers don't even have "PC age" security in their cars, things are looking pretty bad for self-driving cars in general.
It's funny, I trust Apple because they're not "freemium" as in, they make their profit elsewhere. But I'm not sure I should really! After all they did participate in PRISM AFAIK
The NYT has a _huge_ list of experts to contact for stories like this. They chose not to, in the interests of getting a salacious lede printed quickly.
I think the difference is that a cow is only alive because we are breeding it for meat/milk. If we were breeding rhinos for their horns then I wouldn't have any more problem with killing them than I do with killing cows for meat.
Wikileaks said they have the source code but they're not releasing it for now:

"Wikileaks has carefully reviewed the "Year Zero" disclosure and published substantive CIA documentation while avoiding the distribution of 'armed' cyberweapons until a consensus emerges on the technical and political nature of the CIA's program and how such 'weapons' should analyzed, disarmed and published."

Source: https://wikileaks.org/ciav7p1/
These are not limitations of reason.

“Reason is an adaptation to the hypersocial niche humans have evolved for themselves,” Mercier and Sperber write. Habits of mind that seem weird or goofy or just plain dumb from an “intellectualist” point of view prove shrewd when seen from a social “interactionist” perspective."

Once awareness of the game becomes more common, than playing that new game including that new awareness will replace the old game. (Just like saying someone else ate the cookie when caught as a child, gets replaced with more elaborate things like, "you ate the cookie after you came home from drinking 2 nights ago."

Reason evolves.
Botswana has/had a "shot to kill" policy aimed at poachers https://mg.co.za/article/2016-03-16-botswanas-shoot-to-kill-...
You can do that in a canner too. A canner can function as a pressure cooker, but a pressure cooker can't function as a canner.
Ignorant people don't stop believing in nonsense. They have to be simultaneously educated, and there must be protections so that it's safe to criticize nonsense.
I think it's a capital crime in China.
the standard SEB pressure cooker that every household owns in France constantly vents when under pressure - there's a kind of spinning valve on the top that make a choo-choo train noise :)
usually you turn the hob to full until it starts spinning, then you reduce to low for the duration of the cooking
I found the Windows exploits dealing with legacy fax DLL's to be comical. It's arguably the lowest hanging fruit that continues to be the crux of proper security practices.
Is anyone actually surprised? Even military has USCYBERCOM. What do you think their type of 'weapons' are? My only surprise it that this has leaked.
I dunno, I might; I've always skittered along an edge of introversion and avoiding people, but it hasn't been totally crippling to my life and I can keep myself pretty happy between work and hobbies, so I haven't bothered to look more into it.

I mean, there's always the possibility that I'm just a conceited asshole, so why go down that road?
Is Julian Assange a reliable actor in this? He has every motive to deny that Russia are the source of the leaks.
Just like they committed to revealing exploits to the tech industry instead of hoarding them?
You're very much misrepresenting the facts. Android very much encrypts data (or gives users the option to, I'm not certain if it's the default). Chrome, the desktop application, does not. Why? Because that's a false sense of security. Chrome would have to also store the encryption key, and store it in the same place and under the same access controls as the encrypted data. This is not real protection. It is up to the user to not run malicious apps under the same security context as Chrome, and to encrypt their hard drive to protect their data at rest. Nothing that chrome can do in its security context is anything more than placebo - as shown by the fact that malware (and legitimate programs!) can read the Firefox local password database.
I agree. They should be called out on it. The headline is basically "fake news."
Look up confounding by indication and some of the power/sensitivity studies for so-called doubly robust estimators. Counterfactuals are reasonable. A lot of "let's turn this observational study into a designed experiment with math" approaches turn out not to be. That's the gist of it; if you want rigor, you should read the papers. I don't have a reference to hand at the moment (on phone) but it shouldn't take more than a few minutes of searching google scholar to hit the appropriate vein. The bottom line is simply TANSTAAFL.
Hello there! The serverless framework supports a number of different FAAS (function as a service) providers like IBM openwhisk, AWS lambda, & Azure functions from microsoft. See https://serverless.com/framework/docs/providers/ for more info.

So it's up to you where your code runs =)
This link explains it far better than I could: https://www.savetherhino.org/rhino_info/threats_to_rhino/poa...
...at $240 a head. That's what sticks out to me. If anyone is entitled to cut this corner on cost, certainly they are.
> although I can't imagine the CIA wanting to hack the election in Trump's favour

Doesn't preclude planting 'evidence' of Russian hacking to stir up a red scare (towards renewed cold war -level funding of the intelligence community) irrespective of the election's outcome. I.e., the fact that anyone actually uncovered secret data through some other means could have just been unrelated/incidental. E.g., if Wikileaks got their material from an inside whistle-blower as they've insinuated.

I wouldn't either be surprised if the 'evidence' of Russian interference was just circumstantial rather than planted... E.g., "Woah, we found evidence of probing originating from Russia (in the pile of probing evidence from script-kiddies all over the world, mostly Nigerian princes but those don't bolster our narrative)!"

https://www.youtube.com/watch?v=7j_ZfKmcnSk

https://en.wikipedia.org/wiki/Operation_Northwoods

http://www.mintpressnews.com/migrant-crisis-syria-war-fueled...
The browser runs in user space. Desktop OSes don't offer any sort of partitioning here. So there's very little reason to have any app-level encryption on a desktop OS.
No, it's not, not even 'arguably'.
Indian government launches its own GitHub like code collaboration platform
The device is always listening (unless you mute the mic), but that doesn't mean it's always sending a stream to Amazon.

The device has to continuously process audio to listen for the wake word (upon which it does start sending everything to amazon) and a few seconds of the buffer before that so you can just bark out commands rather than waiting for it to acknowledge you.
Yes, completely positive.
You need to make sure that you're following the 301 redirects as that is not the final file location, hence why the data returned is only 957 bytes.
Of course, UX includes performance. If you go to the landing page of a website and it loads very slowly or has janky animations.. they are screwed. It's part of the UX.
"the best offense is a good defense" - 51,600 Google results

"the best defense is a good offense" - 143,000 Google results, and the only one with a Wikipedia article.

https://en.wikipedia.org/wiki/The_best_defense_is_a_good_off...
I don't disagree with you, but in what way do you think Discord will "disrupt" Slack with regards to collaboration?
My personal opinion is much as it has been from day one:

> I'm not about to start using it for real projects,
> it's really just a thought experiment about how nice
> JavaScript could be with an alternative syntax.

(Source: https://news.ycombinator.com/item?id=1014225)

I've used it a bit for fun, but never for work.

And I think that the future of JavaScript is probably always going to be JavaScript — until a web language comes along that's so compelling it's just obvious that it will be the right direction, and then the question won't even have to be asked.

CoffeeScript, as a concept, was mostly finished back in the 2010-2011 days, as a layer on top of ES3.

CoffeeScript 2, while a great step forward in terms of practicality for folks who want to use it with ES6 features like classes and modules — is also a step backwards for the notion of CoffeeScript: For example, we don't have to formalize classes anymore because JavaScript has them now, and unfortunately JavaScript has done them in a very static way that's not at all the direction CS would have taken. Ditto modules.

As an open source project, it will continue to work just as well as it always did. But I definitely don't foresee a return to general relevance, ever.
RTFA. They didn't release the tools.
Sweet, ty did not know about this. Will happily test pilot Containers and Tab Center! (and page shot prob useful too) Just enabled them instead of tab groups and tree style. So far fit my work flow very nicely, hope they make it into main.

(unless you like tab nesting which i guess it cant do? personally just looking for the more readable left-side layout)
In case one is blinded by partisan bias, remember than Hillary Clinton made a similar statement[0] against the pharmaceutical industry during her campaign, and likewise sent stocks temporarily falling.

[0]: https://www.thestreet.com/story/13684503/1/hillary-blasts-dr...
What is a 40-45 Nazi?
Sounds like the sacred Loc-Nar http://villains.wikia.com/wiki/Loc-Nar
Hey everyone!

I've been working on this for a few months, it's an API marketplace that allows buyers to search, integrate, manage and monitor data sources while sellers can track data usage, manage billing and support. Currently it's in the public beta stage and there're a few basic APIs.

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The Blockchain Revolution’s Officially Begun
Sorry to be so blunt but I dont care about another flexbox that much. What they should have done is to implement the shadowdom. Instead we have to wait another half year for them to get to parity with Chrome.
This would not work, the data is heavily cross-referenced. You would simply have more names (as possible neighbors, or rather co-habitators) in your account.