skysight-inc/HackerNews huggingface dataset:
Radiolab did an episode about CRISPR recently, for anyone interested in learning more about CRISPR in general:
http://www.radiolab.org/story/update-crispr/
Wouldn't this still require linear time to scan a database and map users to work?
I don't represent planet, but you have better luck with a question that's narrowed a bit. For instance, who are you?
They could be checking for stellar drift.
"Enter" activates a staircase.
It's interesting to see a right-libertarian argument in favor of a single-payer healthcare system. Single-payer would also support entrepreneurship by decoupling healthcare from employment.
If you use cert pinning, like the DigiNotar/Iran/Gmail, you're still protected against a trusted CA, assuming you've communicated in the past, which is realistic for a real world attack.

It's an attack that's difficult to deploy because it's easy to detect if you're looking in the right places, and as soon as it's detected, you know the CA has been compromised, and the attacker loses a large investment.
It's a ton of people.
LOL!

It's pretty bloody sad state that we're in that your comment cannot be dismissed as some tin-foil-hat-lunatic, but very reasonable skepticism nowadays.
That's ridiculous, every businesses wants to grow and make more money. In their ideal world I'm sure Trello's management would have preferred to buy Atlassian than the other way around. The article does a reasonable job with 20/20 hindsight at musing on how they might have achieved that.
This was the book we used for my abstract algebra course. Robert Beezer also has an open linear algebra textbook

http://linear.ups.edu/
Yes, I was referring to the supply of housing for tourists and visitors, since that's the context the previous poster was referring to.

Regarding total supply of housing for residents + tourists, AirBNB does help here as well. There are a number of people who have extra space in their apartments that they would like to rent out temporarily, without any long term commitments or friction. If AirBNB didn't exist, these people would simply not rent their apartments at all, and that extra space would sit there unused. Thanks for AirBNB and similar services, this extra space is now better utilized to grow the overall supply.

Obviously I don't have any aggregate data on how many people use AirBNB as a substitute for renting, vs letting it sit empty. But anecdotally, I personally know multiple people who use AirBNB but would never take on a sublet/long-term tenant.
.... I guess I have so many other rogue like keys in my head. I swore I pressed '<' on previous stairs but I guess I didn't.
Growing up with an NES my religious parents (at the time) would be very wary of what games they would purchase for me. There was a Christian bookstore that would sell unlicensed Widsom Tree [0] Christian games and they were all kinds of jank, had distinct cardridge shapes and colors [1], and in most cases, had very little Biblical accuracy.

[0] https://en.wikipedia.org/wiki/Wisdom_Tree
[1] http://static.giantbomb.com/uploads/original/0/2538/290022-b...
Citus are doing a fantastic job on content marketing. Every single piece they publish on https://www.citusdata.com/blog/ is a case-study in how to write content (and headlines) that appeal to the kinds of developers their product targets.

"How to Scale PostgreSQL on AWS: Learnings from Citus Cloud" - seriously, how am I as a PostgreSQL-liking developer who cares about scalability NOT going to click through to that article?
Never got around, right. Most of the levels/rooms are okay-ish with respect to doors. What would you expect of a ruined tower hundreds of years old, filled with brambles and fallen plaster...
This is a great place to start: https://levels.io/12-startups-12-months/
> Axei5aoc0i

I don't want to trust a bank who knows my password.
Not exposing it over TCP at all is the only way to do it safely...
Free online invoice – parolu
But even Tamil includes Chettinad cuisine which is quite spicy, I was more generalizing hot spicy is more common in the South vs the North of India. I think that's accurate. Out of the 5 states southern states of India, 3 of them Telangana, Kerala and Andrha seem to have plenty of hot chili spice dishes.
Appreciate your response, and I'm happy you made the comment as it piqued my interest in the subject matter.

Could you help me understand what part of the stated position reminded you of Ayn Rand / objectivism? I'm struggling to make the exact connection.

Is it that ppl who read Ayn Rand tend to project a selfish motive on others?

Also, would love to read more on why you're not a fan of Ayn Rand if you have any links.

And, for the record, upon further inspection, my statement about CL was misleading. CL makes a lot of money, and profits could easily cover the cost of product development. I'm guessing their business philosophy just runs counter to these improvements.
Children also prefer to eat fries and chips
Come to think of it, it's pretty ironic. For years, admins have been told to move static content to a different domain to trim down the request size (since browsers won't include the cookies for the main site). Now that might reverse, and it might be best to send all HTTP requests to the same server (for large sites: most likely some load balancer or haproxy or whatever) in order to benefit from HTTP/2 multiplexing.
Thanks Obie for the kind words and for believing in us back in 2011!
tl;dr -- Employers can charge you thousands of dollars per year not to give your (non-anonymous) genome to third parties who can turn around and sell it.
> I'm going next week to have one removed, and it's about $500, plus some extra costs that are covered by my medical insurance rather than the dental insurance whose deductible I haven't hit yet.

Yeah, I'm quoting a lower end of the range, but the point is that OP was literally paying more than ten times that amount.
watch the documentary Clinton Cash and you'll understand the whole Clinton is corrupt thing.
How do you "signal competence?"
For the higher compensations, the large of it is stock bonus. Unlike base pay, it's hard to count annually for a few reasons:

- They usually vest over four years with a one year cliff.

- The big grants are given sporadically to reward something, not on a recurring basis.

- For stocks like Facebook which are highly volatile (x7 in 5 years) it depends on when you are being given / selling it.
Here's the paper cited by the article ...

http://science.sciencemag.org/content/355/6329/1040

Abstract:

We describe complete design of a synthetic eukaryotic genome, Sc2.0, a highly modified Saccharomyces cerevisiae genome reduced in size by nearly 8%, with 1.1 megabases of the synthetic genome deleted, inserted, or altered. Sc2.0 chromosome design was implemented with BioStudio, an open-source framework developed for eukaryotic genome design, which coordinates design modifications from nucleotide to genome scales and enforces version control to systematically track edits. To achieve complete Sc2.0 genome synthesis, individual synthetic chromosomes built by Sc2.0 Consortium teams around the world will be consolidated into a single strain by “endoreduplication intercross.” Chemically synthesized genomes like Sc2.0 are fully customizable and allow experimentalists to ask otherwise intractable questions about chromosome structure, function, and evolution with a bottom-up design strategy.
I'm a huge fan of A/B testing, and use it regularly. (Even wrote an open source implementation with a backend running on AWS Lambda), but have a bit of a moral / public perception / potential backlash fear of running pricing A/B tests... How do you deal with this? (Or you don't?)
Simon, thanks so much for the kind words. It's nice to know that the content is useful. In general we're focused on sharing both content about how to use Citus and what it's good at, but also good and interesting engineering content as well as we want to add value to our users and broader community. It's great to hear that we're doing alright from your perspective on that front.
people don't realize that free means no charge, but not unlimited.
Doesn't much resemble the real defragmenter, since it just marches forward in strictly linear fashion. (And shows a heck of a lot of bad sectors)

Authentic defrag footage: https://www.youtube.com/watch?v=uVYdSuFFmCU
Exactly. As long as it fits your situation, it's fast enough. My last company used Ruby a lot (and it's what got me hired there), but we hit so many cases where the data was so large that we were forced to use something else. My colleague would fall back to Java, but I used those times as excuses to learn Go.

Where Ruby fits, it's wonderful. Where it just doesn't fit, all of its niceness is overshadowed by its scaling issues.
Well, everybody but the Intel employees here.
You missed the point. It is all about giving credit to those who do the work and make discoveries. It is in poor taste to exploit people in the case of taking their work and not giving any credit to those that made their business model possible.
A few quick thoughts:

> "I don't care about salaries persay, but I do care about being valuable."

You should care about salaries, even if you don't care about salaries.

Yeah that sounds insane, but salary is a signal for ability. It probably shouldn't be, but hey, I didn't make these crazy rules.

Having a high salary opens doors to many interesting jobs doing really interesting work. For a long list of (very unfair) reasons, someone making $300k gets taken more seriously than someone making $100k (even at companies that can't afford you!).

So yes, you're right about working with great mentors, at great companies, and with great teams - but you should also focus on getting paid more. They're all tied up together and each contributes to the others.

As to how to break into the cycle of high salaries -> high impact work -> higher salaries -> higher impact work...

That's a good question. Joining one of the AppAmaGooFaceSoft big corps is one way about it - the hiring processes at these companies are less network-reliant than many other jobs, and all are famous enough that it massively opens the door to further work. I had the good luck of starting my career at Amazon, which opened many doors.

(I also had the great luck of not staying at Amazon)
This is like the opposite or corollary of the "$5 rubber hose" cryptography cracking device.
"Let me tell you how you to build a $1B business. I've never done it, but take my word that I know how to do it better than someone who sold a half a billion dollar business."

Like really, if your advice is useful, why hasn't the author built a $1B business? It seems like they missed the point that Trello became giant for what is essentially networked sticky-notes, were they even trying to become a $1B Business?

Next week: Why Trello Failed To Be the First Company On The Moon (spoiler alert, they weren't trying to do that).
I don't doubt that Nadella is likely every bit as shrewd as the CEOs that came before him, and that his decisions are driven by ulterior motives that are more than what meets the eye.

However, shrewdness is just one trait, and I think it's disingenuous to insist that we can reasonably ignore all other consequences of having a different human being running the company because their shrewdness makes them as interchangeable as planks on a wooden boat.

Personalities and management philosophies can't be reduced into some simple measure on a shrewdness scale, and the other differences between these real human beings that you don't seem to be taking into account can and do bring real change in how the company behaves and operates. Maybe not a lot of the change is concentrated on the axis that you've cherry-picked, but that doesn't mean we can dismiss all the other change that may have resulted from this change in management as "next to nothing".
What an odd response. I think it's a perfectly reasonable question to ask. Why does it matter who the asker is?
A few times I've wanted to make a script to download all those highlights into a text file, but I've never bothered... would still be really nice though.
Machine Shop Tour: Lawrence Berkeley Lab with Tom Lipton
I can get median pay data from the BLS [1] without visiting the cesspool that is reddit.

The median software developer is shockingly bad. Some developers will claim to be 4+ sigma talent, but you don't need to be one of them to make $250k.

[1] https://www.bls.gov/ooh/computer-and-information-technology/...
Because our culture does not allow for providing a decent quality of life to everyone.

I grew up poor, in one of the reddest of red states. I've been party to literally dozens of arguments, family, friends, coworkers, in the grocery store between randos, didn't matter who... the local cultural meme is: "You don't need teeth/glasses/asthma meds/whatever to live.". "Be glad you're not dead." is usually what follows. Poor, broken, but "alive".

It isn't generally available to people with no money, so they build an emotional avoidance mechanism. A "hard living" mentality. Stoicism run amok.

Politicians and neo-liberal economic policy take advantage of this.

The experience may be subhuman in the figurative sense, but in a literal sense "you'll live."
Random semi-related question I was thinking about last night:

Could you:

1) make a coarse "random" mirror that was bumpy at the large scale

2) buff out all the fine texture so you get clear fragments of an image all across the lens at random focal planes

3) put it on a track with a LCD screen on one side and a camera on the other

4) use some sort of gradient descent algorithm to move the image and camera around and reverse engineer the normal map for the lens

5) Use that displacement map to generate a light field from an image

6) Use the light field to generate any (clear, in focus) image you want in the light field volume.

In other words, can you make a Very Bad but Smooth lens, and then make up for it in software?

My guess: you could, but for any given focal plane you'd recover very little resolution because probabalistically few of the microlens fragments are focused there.
> In our case at Hunter, users were waiting on average 270ms for the handshake to be finished. Considering requests are handled in about 60ms on average, this was clearly too much.

Why? Did it hurt user engagement? Were people complaining the site was slow?
The big perf drop in VS was between 2013 and 2015 when Roslyn was introduced (not sure if that's the reason though). It has improved somewhat in 2017 but I still find 2013 to be significantly faster than 2017.
I've seen someone fall off a cliff (30m I guess?) and survive. He was drunk.
Regarding the downvotes, I had to read your top level post three times to understand what you are getting at:

a) Mexican pot growers need a new line of business, now that it's legal to produce for the medical and recreational markets in many places in the US.

b) Therefore they are supplying heroin addicts in the US.

The first time I read what you wrote I got the impression you were saying cannabis is a gateway drug. I didn't understand you were talking about the effects of legalization on Mexican traffickers.
I was looking for the "I want my database to be performant under high random load" question. PIOPS can hurt.

Anyone have any experience running PostgreSQL on the new I3 instances?
On the 5th floor or so.

There probably needs to be a game clock (the usually implementation is hunger or enemies spawning).

Otherwise you can just go in a room and walk around till your back to full health.

I assume the author knows this.
Seems doubtful this would have any significant effect. You can only create about 0.1 bar of overpressure with your lungs on exhale.
Sidenote: Planet presented on Google Cloud Next 2017 keynote today: https://youtu.be/h9FSqVbdHis?t=8109 They told that they use Google Cloud Platform to store 7+ PB of data and upload 7 TB daily with a hockey-stick growth trajectory. Personally their mini satellites were my favorite part. Disclaimer: I work for Google.
Articles like that are very annoying. Annoying, because this is not actually the highest salary an engineer can make, but the highest salaries reported. The word "can" is used in the wrong fashion.
Ask HN: How did you meet your cofounder?
The immediate cause, of not being able to get methadone after the court had ordered it, seems straightforward to fix. Whatever rule prevented the GP from prescribing it can be changed.

Changing the maintenance programme itself might take more effort, and according to this article, more research is needed: http://www.bbc.com/news/uk-scotland-31943109
It is questionable if OCSP stapling reduces TLS handshake time.

Without OCSP browser makes slow request to CA, but caches results for a long time so slow request happens not often.

With OCSP stapling enabled more data is transferred between client and server on each TLS handshake.

Main proponents of OCSP stapling are CA, because it saves them bandwidth/hardware.
Something like WeChat really isn't like cards though. It's more like cash, cards and bank transfers in one. Like if most everyone would accept Paypal for everything without fees and it was integrated everywhere (web, store, phone, chat etc).
> There have been a couple of times where I wanted to understand how an interesting library or bit of code worked, so I printed the code out and made notes right on the page as I read through it.

I do this as well, although I usually get a page or two in, figure out what the code does, and regret printing out the rest. Still worth doing, but I need to train myself to waste less paper.
Shell out for the 5 year next business day onsite warranty. You get an entirely different tier of phone support and the onsite folks are the same ones who come to take care of my Lenovo stuff. Did this with my XPS 13 (9343, early 2015) and they have been wonderful. Had an issue with the space bar double-clutching and they showed up at my office the next morning with an immediate fix.

It's been a great machine.
Dude. P.D Eastman.
Are you from the Chrome team? Or how do you know it's enabled? The above demo doesn't work for me because it says I don't have WebGL enabled - yet I do. It may be some other setting messing it up.

It seems strange that Google would not even mention such a feature being enabled, though.
Seriously diminishing returns may be emerging in bulk collection. The disgruntlement this is creating in the intelligence community work force and the recruiting pool may not be worth the gains. Hard targets must be taking counter-measures as awareness grows. But, in fairness to the IC, its really a political problem. If zero tolerance is the goal for attacks against the US then zero privacy is going to be the result.
Oh, that's definitely something we worry about a lot! One thing to note is that each record contains a lot of data in it, so it's not as though there's just 100 data points we have to go on. A 24 hour record has ~20 million data points, it's just that they are highly correlated with each other.

Cross validation helps to some extent. If you're fitting enough models, though, you can still trick yourself into thinking that some models are not overfitting, when they just happen to do well on your validation set by chance. But one of the things I look for is a smooth transition from underfitting to overfitting as the model capacity increases.

Then the other thing we do is probe the models so that we can understand what they're doing as much we can. I like to generate synthetic data and look at the transfer function of the model as I vary a particular parameter in my synthetic dataset, for example.
This has been my experience, too, mostly. I ran both a 32-bit and a 64-bit Linux desktop on an Athlon64, both for several months, and I did not notice a difference in performance.

About the only real benefit is that the system can handle more RAM (which of course is a good thing). For some applications that are very, very memory-hungry, this can improve performance dramatically, because the program no longer needs to juggle all that data and can just keep it in RAM.
Pricing can be one of the most complex topics in business. About twenty years ago I read through what I consider to be THE book on the subject, "The Strategy and Tactics of Pricing":

https://www.amazon.com/Strategy-Tactics-Pricing-Growing-Prof...

What I learned was invaluable. I do have to warn you, the book lays it all out. This is excellent, of course. However, what happens is your level of confusion as to how and why to price using a certain approach will grow as you progress through the book.

Somewhere past the middle things start to coalesce and your choices become clearer. Again, this depends on the nature of the product.

Please note this is not a critique of the book at all, it's excellent, this is a complex topic and it is only natural to be confused before reaching clarity.
This article significantly misrepresents the study. It says that children prefer to read on paper than on devices, which indicates that children were asked about their preferences, or asked about habits that are likely to reveal their preferences. This is not the case.

Subjects were never asked which they liked better, and the underlying research report clearly indicates that the differences in their behavior between reading on screen and on paper could be due to their lack of awareness of where to get free ebooks.

Since kids don't have credit cards, they wouldn't be able to buy Kindle books, and might not even have an account. So looking at observational data about what kids use to read books is not a good way to determine what kids "prefer" in this instance. You'd have to give kids the same books in paper and on digital and then see which one they end up reading.

The underlying research is fine, and appropriately nuanced. The article describing it is misleading clickbait.
I’ll take a different tack than most other comments. Assuming you’re B2B
Step 1: Determine how much value your product creates for your customer
Step 2: Set your price at a majority chunk of that

Example: How much money would you be willing to pay for a lead list that could make you $100 in sales? Assuming you have no internal cost to acquire (for sake of simplicity), if you paid $90 for that list, you’d make a 11% ROI. What sort of ROI do your customers need in order to bite?
That's my first thought. Why not just do it yourself? Especially when twimlets are around.
What's absurd about elves? If it could be little green men, maybe they have pointy ears. This is science after all, as long as it's a hypothesis, it counts, right?
Cars, retooling and jobs of the future
This might be the case - but the IDE isn't really complete withiut extensions. I need svn integration, and I need basic refactoring from R# like "move type to new file".

The problem is probably that memory is crowded and plugins must do a lot in-process via COM.

If Microsoft really wanted to make VS fly for a lot of people they could just add the 10% most popular features from the 10most popular extensions. It would want nothing more than to throw out R#
Tips, How to Launch a Product on Product Hunt (Case Study)
Besides crypto. What applications does Abstract Algebra have in CS?
> 2) Given an array of zeroes and ones, sort it stably using O(n) time and O(1) extra space.

I'm missing something here. If the array's values truly are all in {0,1}, then all the zeroes are indistinguishable and you get stability for free (same for the ones).

mysort all01list = let ones = sum all01list in replicate (length all01list - ones) 0 ++ replicate ones 1
Well, my point was really about GPs and family doctors needing to be familiar with various ways to treat opiate addiction.
I have always wondered about this. While this is welcome, I am reading and can feel my blood pressure, stress level, and focus increasing as I read.