skysight-inc/HackerNews huggingface dataset:
A big part of the 21st Century Cures Act is to incentivize new antibiotics. Right now the FDA requires the same standards for antibiotics as for other drugs.

That can be a problem if you are trying to test a new antibiotic for a very rare drug resistant strain. You need 100 patients in your trial to hit statistical significance, but only 50 cases happen in the US each year.

So you run a smaller trial, get the best data you can and the FDA gives you conditional approval. You agree to a patient registry to collect post approval data where in time you get full FDA approval.
In college I brought an iMac to learn edit video in FCP7. It was nice, not really fast but functional, a lot of my professors were apple fanboys since the Jobs era. Then came FCPX, even if it's good right now, the first version released was basically a stab in the back to those video pros who were faithful to apple for years, those were who keep buying in the hardest times of the company.

I saw a lot of video professionals jumping to the Adobe Ecosystem or to things like DaVinci for the GPU rendering.

In my case I ended up selling my mac, and with the money build good PC for the price. I feel stupid of not building one from the beginning. Good bye external disks and weird perif; hello SSD, RAID Storage, expandable RAM, and a GPU with CUDA that I can upgrade in two years, without trashing the rest of the system.

This is not a debate of Mac vs PC (that can go forever), or a PC Master Race propaganda, but the Mac Pro it's a bad taste joke. I get the idea of the "apple tax", but it's ridiculous here. The CPUs, SSD, and RAM are old, but specially the fact that the GPU it's soldered in the Motherboard it's just stupid. GPU are one of those rare things were you can still see the double of performance in each new iteration.

I love my Macbook Pro because reasons, but in Desktops, the PC it's the King.
He is pointing out that cloudflare is also hosting the DDOS sites.

Those are sites that you can go to to pay for a DDOS.

So they are taking money from the people who you are paying them to defend you against.
Reminds me of this apt explanation of the situation: https://m.youtube.com/watch?v=-GTAVsMqa-U
External GPUs are explicitly supported by Thunderbolt 3, and some people have had success with it on TB2 as well. The 4x PCIe 3.0 lanes offer enough bandwidth for most purposes. It's kind of poorly supported on Mac OS though, and the enclosures aren't cheap.
> people who are good at heart don't let their company's culture get like that

This kind of comment is too harsh and over-simplifies the kind of decisions that growth-phase startups have to face. You have many battles to fight, and sometimes you have to make a trade-off. In Uber's case, they prioritized hiring and firing people to manage performance over dealing with culture issues. Not saying the trade-off they make is right - I think they all realize now they cannot treat themselves as a startup any more - but claiming the management at the company are not good at heart is just totally unjustified. Do you also think startups that lay off people when they don't need them or move operations to cheap regions to also have bad heart?
Show HN: Ques ( commentary on some questions from Ask HN )
People with the silver 2009 Mac Pros are also mad because Sierra won't run on it. It will run on a 2010 Mac Pro which is, for all intents and purposes, identical, except a BIOS version setting. Apple decided 2009 users now has obsolete hardware. It's only 6.5 years old and mine is from obsolete. 2x4 3.33, 32g, 2x1TBSSD, 2x4TBHDD, USB3, GeForce 970.
Regression testing on the cloud: challenges and helpful tools
What about Thunderbolt 3?
Computation is an entirely abstract thing. Nowhere does the definition of Turing machines or the lambda calculus makes any reference to actual physical things.
> but with Google's name behind it

Yeah, given the developers, I wonder how seriously to take the "not an official Google product" statement.

> I feel bad for the Keybase team right now

I wonder what they are going to do to respond to these developments...
What about standing desks? Have you tried taking breaks every hour?
I guessed about a 100 and that's a little low. Half the US lives in the top 146 biggest counties.

http://www.businessinsider.com/half-of-the-united-states-liv...
Why Did Greenland's Vikings Vanish?
If it is literal dog food, you feed it to your dog.
DDoS protection and general ease of use. There are several options for the extent of encryption between CF's edge and the origin server but the onus is on the site owner to configure it properly.

Sure it defeats the ideals about TLS and the internet in general ala "every connection should be point to point" but we've been ruining that with firewalls and NATs for a long time and having some degree of TLS is still better than nothing at all.
Wow if these run as fast as they say one could replace tens of GCP machines with a single i3.xlarge, or you could go with a 2-4xlarge just for giggles and still come in far under budget.
Traditional IRA's are more appealing than they seem, even for low income earners. It is entirely possible to pay $0 tax on withdraw from a traditional IRA.

https://www.kitces.com/blog/understanding-the-mechanics-of-t...

The attractiveness of a traditional IRA only increases as your marginal tax rate does.
Any chance you can describe why these cached pages missed the purge that cloudflare initiated? Seems like cloudflare should have brought an outside expert to try to exploit this issue before the disclosure was made.
The newer R4:

r4.xlarge: 4 vCPU / 13.5 ECU, 30.5 GB RAM, EBS only, $0.266 per Hour
What about the TSA people asking for your cell phone at the airport? The whole border crossing incidents
Cloudflare has spent a lot of time gaslighting people into believing this, but it physically, scientifically, OSI model-y isn't true. Cloudflare hosts web sites. When Cloudflare CDN edges that content, that content exists on their servers. Just because the canonical store is on another machine doesn't mean they don't host the site. If I mirror a site from some other server, and you're loading that site from my server, I'm the one hosting that site. That's how HTTP works.

The argument that they don't know what's hosted on their network has also been demonstrated by evidence as nonsense. The reason the Pirate Bay got blackholed by Cogent last week was because Cloudflare was grouping all of the BitTorrent sites on their network onto a single IP address, and a Spanish court order related to a different site ended up BGP blackholing over two dozen torrent-related sites as collateral damage.

http://seclists.org/nanog/2016/Jul/400
https://mailman.nanog.org/pipermail/nanog/2017-February/thre...

Cloudflare is completely capable of enforcing this, yet they don't do anything about it. It benefits them financially to not do anything, because they get business from these DDoS attackers trashing other networks on the internet, making it so you can only have sites stay up if they are hosted by Cloudflare's broken, bleeding servers.

This is fundamentally an extortion racket. Frankly, it should be a crime. This is exactly the kind of problem laws exist for.
Can we trust it was only those domains?
I feel like this depends a lot on the location.

My mail got delivered wet a few times, so I complained. And all they said to me is, it got wet because it was raining. They basically said that there is nothing they can do when it is raining...
This will not cover all sites[1].

1. https://support.cloudflare.com/hc/en-us/articles/202320534-C...
I wrote a script which checks the domains you have visited from your chrome history to see if they use Cloudflare by checking if the header `cf-ray` is present in their response headers: https://gist.github.com/kamaljoshi/2cce5f6d35cd28de8f6dbb27d...

Found my bank's site on it. :(
What's absolutely hilarious is that a lot of the self-driving tech was originally funded by US, the American Citizens and google simply used it and worked on it further. Maybe every American should get shares in Waymo!
Profitability is missing. IPOs are a distant dream. Valuations are high. Investor money is stuck, with no good exits in sight.
Be careful posting random domains.HN might flag/throttle your account for spamming.happened to one of my accounts.
You're incorrect. This data is not in OSM or elsewhere, it's fragmented.

People have tried to build massive databases of places, yet there are clear gaps in the data all over the place.

Perhaps topic-based apps and data are better. Here's the solution for that, starting with Café Wifi.

If you think one company and site can do everything well, look at what is happening to Facebook.
I had a terrible experience with a Lyft driver. I took a Lyft home after a long flight where I wasn't feeling well. I mentioned something about not feeling well. The driver decided I was going to die and mess up his car. Then, he tried to dump me at McDonalds. Only after arguing with him for 10 minutes in the McDonalds parking lot and refusing to get out of the car, he reluctantly sorta agreed to take me to the hospital except he took me to the children's hospital.
Huh TIL. Good call!
Since all current and just voted recreational states also have a medical program, most people will probably just get a recommendation from a doctor, depending on how lax the laws of their state are. If they're not lax, they will hopefully be changed to be (lawmakers, please see California for a great example). This will either set back progress and the will of the people, or hopefully, stage a huge fight where the states stand up for themselves and demand that this administration respect their constitutions and therefore the will of the people.
You know a company isn't serious about security when their top security bounty is a t-shirt. Instagram has a better policy, for God's sake.
Google blacklists Natural News (naturalnews.com)
I really doubt wall street is spending hundreds of millions of dollars on equipment because they care about market liquidity. These people/services add absolutely nothing of value to society yet they suck up billions of dollars.

Very relevant:

https://youtu.be/TFPugioX7uk?t=22
> Was it all just Jony Ive design hubris? Who is the Mac Pro designed for?

Apple consistently chooses form over function, but they don't usually let the scales tip this far. The last time they fucked up this bad was the Mac Cube, but back then Apple was proactive enough to kill the Cube within 6 months. It really surprises me that Apple hasn't come out with something to replace the current Mac Pro.

Microsoft realized that the niche creative-type markets that Apple has historically owned tend to be broad-market influencers, and they've started to target them with products like the Surface Pro and Surface Studio.

Competition is great, and it will be interesting to see if Apple will rise to it or fade away.
The natural health website Natural News- notably anti-establishment and recently pro-Trump- has been blacklisted by Google, 140,000 indexes removed.

I have been visiting this site for over 5 years and have much appreciation for what they do. The Trump thing was interesting but raised many important questions.

Google gave a 'Violation of Webmasters Guidelines' for the blacklisting.
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Vlad and Arseny.
It's probably worth giving some qualifiers on the grandparent comment. In short, the depressed population is bimodal with close to 2/3rds not responding to SSRIs and similar treatments satisfactorily and 1/3rd of people responding well. For the most part this is due to all of the different causes of depression being lumped in together. When the root cause of your depression is brain chemistry then you need the drugs, but if its secondary to environmental factors then it'll be less effective than lifestyle interventions.

This leads to people saying that those lifestyle interventions are more effective in general, but that's due to them being appropriate for more patients, while there's a smaller population for which these interventions won't work well. Good doctors/psychologists will identify which patients are which over time.
JSON-LD – JSON for Linking Data
Apparently, the only way to change one's Uber password is to use the 'Forgot password' path on their login page.

So, I clicked on that - and I get a 500 error from NGINX.

My guess is that a lot of services are going to be overwhelmed by the sheer volume of password reset requests, thus preventing users from resetting their passwords.
I think this is a very interesting perspective. If I understand correctly, your argument is that a Mac Pro product need not be a direct profit maker so long as it perpetuates Apple's position as a top end computer manufacturer. Have I understood correctly? Or are you perhaps prognosticating a change in market demands rendering such a product less relevant?
A note on our (Waymo) lawsuit against Otto and Uber
> To the voter id laws, I can provide studies showing that in person vote fraud is non existent in America

I think it might be better to say "irrelevant to the outcome of an election" than "non existent".

One kind of in-person vote fraud which can be measured is voting twice: mail in a ballot in one district and vote in person in another district, or (more rare) vote in person in two districts. There were as an order of magnitude guess 400-1000 people who voted twice in both Florida and New York in 2000.

And other isolated incidents have been detected, e.g. in 2002 perhaps as many as a few hundred people in Kansas voted in person in two different districts (sometimes two places in Kansas, sometimes one in Kansas and one in Missouri).

See http://www.slate.com/articles/news_and_politics/politics/200... for the sources here; local newspapers pulled the voter records and cross-checked duplicate names by hand, reaching out to individual people to ask their stories.

The issue of whether or not voter fraud is a serious national problem was a big deal in the early 2000s, when the executive branch of the federal government put a LOT of work into trying to find and prosecute voter fraud which they believed was a big deal. They were generally unable to find lots of fraud and their failure to find significant fraud was a big part of the reason that a bunch of US attorneys were, controversially, fired - https://en.wikipedia.org/wiki/Dismissal_of_U.S._attorneys_co... , https://www.brennancenter.org/sites/default/files/publicatio... .

With respect to the "vote as someone else" in-person fraud problem, that's a lot harder to measure. It seems like if it were an endemic problem we would have found it the last time we went hunting 10-15 years ago.

Still I am definitely sympathetic to the idea that everyone should be issued a free, easy-to-get national ID card. Perhaps we should get that system up and running and as soon as there are fewer than (say) 100 cases per year of people being denied an ID despite presenting sufficient documentation, we can think about requiring it at the polls. (When ID-issuance goes wrong it goes really wrong -- see e.g. https://www.thenation.com/article/wisconsin-is-systematicall... ).
OK, but even if you disregard voter ID (others have explained that issue well here already) the Republican party has engaged in a large number of other methods to supress votes. Fighting to overturn parts of the voting rights act , Gerrymandering, reducing polling places in cities with demographics that tend to vote for Democrats, removing early voting days and fighting against vote by mail (methods favored by Democrat leaning demographics), and the list goes on.

The Democrats have engaged in many of these same methods in the past btw, but today's GOP have taken it to the next level. So far that I question if many Republican leaders believe in democracy at all anymore.
Some other famous chemical assassination attempts: http://www.ctvnews.ca/world/a-look-at-assassination-attempts...
I would guess that politicians now believe (true or not) the most effective way to get elected is to pursue lobby money and use it to run scare commercials at people who are "political children," a Dan Carlin term. The fact that this is more effective than what you described is additionally troubling.
I can't change my Uber password - first, the only way to do so is via the 'Forgot your password' dialogue, and second, that now produces a 500 error from NGINX.

Lots of services are going to crumple under the weight of frantic password-reset requests.
Someone insecure who does not retaliate is of little concern. Someone who can retaliate or do away with people in remote places using extreme methods is more about saying, "don't cross me or I will get you" and insecurity is kind of irrelevant at that point. It's more I don't want to get on this woman/man's bad side.

I'm also not sure it's plain insecurity. I'm sure there are people not too far removed from him who if they could, would try to get to him -however, he goes to extreme measures to ensure he neutralizes possible threats when identified --including relatives and "old hands".

Although, being such a tyrant (insecure as he might be) why doesn't anyone of the people at his core who live in fear for themselves and everyone else just go on a final mission against him? It's not like he's the only one armed --plus he'd have to remain awake 24x7.
I've found trains are very good outside the US.
The Cube didn't replace the Power Mac. It was sold in addition to it. If you compared them on specs alone the Power Mac was cheaper and faster so literally the only reason to buy the Cube was because it looked nice. (Or maybe because your desk was really small.)

The current Mac Pro replaced the old Mac Pro, though. That's the difference. If you don't like it, your only other choices are iMac (built in monitor) or Mac Mini (horrifically underpowered).

Apple could kill the Cube without consequence, but the current desktop Mac lineup is so limited there is no alternative.
not trolling, I followed your HN profile link: what blog post? http://blog.jgc.org/
> Apple is well-suited to fund a loss-leader products that bolster their cachet in the professional community

They could do this, but they have yet to prove that they will do it. Ever since Jobs, Apple has been hyper fixated on focused, profitable product lines. The Pro is out of step with that, and I bet with laptops making up the bulk of their computer sales, we'll start seeing them move away from the iMac too.

My only guess right now is that they still feel they need the Pro to maintain their computer business, but I fear they are slowly becoming just a gadget company and will forget their roots.
A new version every year, and space for multiple internal SSDs, would have made it desirable.

However, Apple is now milking the old glory and failing to build tomorrow's glory. It's the classic beam counter mistake. It's probably time to short Apple soon.
Or Microsoft antitrust?
By whom? What do you think the public or the media would react when they see a young woman fighting with a multi-billion dollar company that is already in a PR crisis in a sexual harassment case? The truth is always more nuances than just true or false. If as a community we learn a good lesson, then all this is probably worth it.

As for Ms. Fowler, I don't expect her to be a neutral figure, and if you read her tweets, who called for boycott of her ex-employer based on false information, she clearly is not.
That's what was observed on the Cloudflare end. Without the multiplicand of how many pages Cloudflare served in a given amount of time, you can't determine the impact. Assuming that affected sites were affected en masse, a targeted attack from a connection would be minuscule compared to the pages Cloudflare serves.

Cloudflare is serving up more than 100Mbps; the attacker only has to zero in on what's fruitful, which yields something far higher than the 1 per 3.3M Cloudflare sees serving millions of innocuous requests.
Cloudflush.
I need popcorn and front row seat for this
Many services on the internet keep a copy of a page they have loaded in the past. Google does this, for example. It lets them do things like search across websites quickly.

Many of these caches are available online, to anyone who wants to look at them.

This bug meant that any time a page was sent through Cloudflare, the requester might receive the page plus some sensitive personal information, or credentials that could be used to log in to a stranger's account. Some of these credentials might let a bad actor pretend to be a service like Uber or Fitbit.

This very sensitive information might end up saved in a public cache, where anyone could find it and use it to do harm.
I'm glad to discover that I'm not alone in that, "Hmmm, I wonder if my internet history has put me on all of the lists yet?" reading pattern. On Wikipedia especially, the fun is opening an endlessly nesting series of related topics. Sometimes that can get... weird.
Yeah. It was awesome when it came out...
Snooze Tabs and Pulse – New Experiments for Firefox Testpilot
Indian Techies Don’t Need the US–Their Talent Is Welcome Elsewhere
I have 16 GB of memory with swap off yet still sometimes get lag and freezes due to low memory. An aggressive OOM killer or a performance watchdog should be considered a mandatory feature. On desktop I'd much rather have my programs shut down than get any lag.
"Undocumented immigrant"? You mean illegal alien.

Also, providing ID is pretty normal. Especially on flights. Even domestic ones. Or so I thought. Then again I live in communist Canada.
We tried a Razer Core on a MacBook but it wouldn't work.

Works great with the Razer laptops though!

(BTW, you can't even buy any Mac with a decent GPU anymore, no matter what the form factor!)
Telling Google about exploits in Google services in exchange for money is not illegal.

Telling them about exploits in other services in exchange for money might be, depending on context.

Your parent was talking about the former case.
Using Firebase with Angular
Cloudfare's bug bounty maximum reward[1]:

1. Recognition on our Hall of Fame.

2. A limited edition CloudFlare bug hunter t-shirt. CloudFlare employees don't even have this shirt. It's only for you all. Wear it with pride: you're part of an exclusive group.

3. 12 months of CloudFlare's Pro or 1 month of Business service on us.

4. Monetary compensation is not currently offered under this program.

Guessing they're gonna reconsider #4 at this point.

[1] https://hackerone.com/cloudflare
Php Web Development Company India
Data Mining OCR PDFs
This harassment calls to mind the most negative possible stereotypes of silicon valley tech bros. Misogynistic, rude, deeply unpleasant people to be around. The question is how did those people get into Uber in the first place, and why are they allowed to stay while all of their victims leave?

I don't give a fuck how much that woman was getting paid, it is not conditional on her receiving sexual harassment from her supervisors. It is conditional on her doing her goddamn job, and making people feel unsafe by directly propositioning them obviously interferes with that.
Welcome to HN :)

It's one of the reasons I leave this site every day feeling wonderfully inadequate :)
> 1) can't install internal PCIe cards like BlackMagic Decklink cards 2) can't install desktop GPUs, 3) Can't install multiple internal hdds

The story was that for this expansion, you'd add external chassis. I'm not a video person, so I'm curious why this didn't pan out?
If someone is an asshole to women and not to men, he's sexist. But if he's an asshole to everyone, he's just an asshole.