skysight-inc/HackerNews huggingface dataset:
Yep! There is some error-checking built into dna-replication. The protein that does the replication is called DNA Polymerase. From its wikipedia article:

Error correction is a property of some, but not all, DNA polymerases. This process corrects mistakes in newly-synthesized DNA. When an incorrect base pair is recognized, DNA polymerase reverses its direction by one base pair of DNA. The 3'-5' exonuclease activity of the enzyme allows the incorrect base pair to be excised (this activity is known as proofreading). Following base excision, the polymerase can re-insert the correct base and replication can continue.
if you want to get people to buy into your idea, you often have to convince them that the idea was their own.
Google Ventures.
Funniest S1 filling ever. Just have a look at the Risk Factors section.
this has been already discuss, this is blog spam
So then nobody makes money (off the original idea at least). Why not just patent and sell it yourself?
I think the answer to this lies in regulation, but I think we also need to start treating the thriving market for our personal data differently. Privacy and regulation is super important. But I think we, as "products" also need to become active, engaged participants in the economic market for our personal information. We should have profit sharing agreements with Facebook to resell our data, should we consent to data sharing. Only then, I think, will we really have a stake that is worth more than writing angry articles and blog posts.

I wrote an expanded version of this comment as a blog post here for anyone who wants to read it and comment, here or there.
http://edwardbenson.com/facebooks-product-is-you
You obviously have no idea how often and prominently thoughts like "I must not be a victim!" or "I must pull myself together" feature in the compulsive thought patterns of a depressive's experience, deepening the depressive state, especially if the person used to be very creative and productive. Seriously, please do not suggest to a clinically depressed person that they "just need to power through this" or something, because they are quiet likely to try, and they might end up killing themselves because it doesn't work. It's like persuading somebody with a broken leg to run a marathon, saying "Don't be such a wimp! No pain, no gain!".

"Victim or not" is simply in the wrong ballpark. A depressive person is a patient. Many of them have real trouble with accepting this fact, which is a symptom of their disease. If you're not depressive, you should have less problems understanding it. Please don't make it harder for them by pushing in the wrong direction.
Wow. That is, dare I say it, ballsy. I think this is destined to be an interesting anecdote for Mr. Richard later in life. I get the feeling the lawyer, Rory Vohwinkel, is a family friend who does this all the time (Las Vegas is ground zero for, er, marginal corporations).

Interesting note - it's $12,500 for 20% of his company, a typical seed-level investment. I often wonder about the wild and woolly world of penny stocks, but never to invest in. Does anyone know what the downside is for this company if they have no better funding options (and I wouldn't be shocked to find out they didn't)?

Also, this guy's business approach is still far superior to that of the Bulletball guy.

http://www.youtube.com/watch?v=WOOw2yWMSfk
Xbox joysticking unlikely for game set inside vagina
That This American Life episode was the first thing I thought about when I read this news. I heartily second the recommendation that everybody listen to it. It made me very happy that the NUMMI plant was going to get a new lease on life. I hope Tesla makes it.
OnlinePrintingHub
Attempt at a summary from skimming it:

* He sells "custom-made beer pong tables and related products"

* No revenue to date

* He owns 9.5M shares, and he's trying to sell 2.5M shares of new stock for a total of $12,500, which I think means a pre-money valuation of $47500 ($12,500 * (9.5/2.5))

* One of the risks he lists is "If we do not obtain additional financing, our business will fail."

* He plans to use the money to build tables that he can sell, including designing and building themed tables (such as a table with a college's mascot and such on it) and to build a good website
I love it, stuck it on my bookmark bar especially for doing conversions which I find google often misses (or often enough).
Cool! Is it public? How old is he now?

At 15 I never brought it further than writing small basic programs on a tandy 'pocket' computer.

The first time dabbling in languages was writing a 6809 macro assemlber, but that had to wait until I was 17. Those really young kids cranking out code at that level really amaze me, I don't think I had even heard of LISP at that age.
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Way to think ahead.

I guess I should say everyone flag it then. But who am I to tell people what to do?
Brilliant. I assumed Finance Major at UNLV but he seems more rodeo champ - http://www.myspace.com/turnumburnum

Check out the MySpace wall post from BrO4LiFe13 on 4 Feb (ie, just over two weeks before the company was created): "there is some ppl that want a beer pong table so if you want to make some money tell me".

From such things, a business empire may be born.
I could have sworn it was put back up a bit later. This same thing was posted on Reddit a few hours ago and someone gave a direct link saying it was back up and the page creator said they had issues earlier but thanked Facebook for putting it back up.
Eighty percent of success is showing up. -Woody Allen

Punctuality has paid off well for me. Seriously, show up to work on time everyday and make everyone look bad in comparison.

Customer service has also been a very valuable experience, dealing with a whole range of people. Learning the art has given me the confidence to interact with anyone, from executive to teenager, co-worker to police officer.
Persuading isn't really my forte, but my bullshit detector is well honed.

My advice is get a job in a fast paced but low risk service environment that serves a range of people, the classic example is waiting tables. Master this and then use what you've learned.
Bacteria will often take up DNA from their environment, and this ability, called "competence" is widely used in molecular biology. In this case, they treated the cells with a chemical called polyethylene glycol, which increases the efficiency by which the cells can pick up the DNA molecules. The procedure for transplanting genomes was described by the same group in a paper in 2007. It is possible to use a small needle ("DNA microinjection") to inject DNA into cells; one can also use an electric field to disrupt the cell membrane and force DNA into a cell, which is called electroporation. In this case though, the PEG transformation was sufficient (and because these artificial chromosomes were so large, they might not survive being shot through a needle or zapped with electricity too well).

The initial pieces of DNA (oligonucleotides) are synthesized chemically - the components are added to a reaction one at a time, and the reaction is controlled so that at each step, only one base gets added. There is a lot of chemistry optimization and QC to be able to make relatively long fragments accurately. They ordered the building block pieces (1080 bases long) from a company called Blue Heron, which specializes in putting together long DNA molecules.

The sequences were designed to be partially overlapping, so that the complementary sequences could fit together. Overlapping pieces of DNA can be combined by a process called homologous recombination. There is existing machinery in the yeast cells that they used to join together such complementary sequences. The molecules were assembled hierarchically, so they first made 10kb fragments, then put 10 x 10kb together to make 100kb fragments, and then finally put the 10 100kb fragments together. The overlapping sequences at the ends determined which fragments will stick together.
By far the best way of approaching this is to look for suitable ex-colleagues - either they've left the company or you have. Solves pretty much all of the nasty issues.

Also make sure you think about the long term. Sure, you're not trying to hire them away from the company now, but what if your side project is unexpectedly successful?
Add downvoting to submissions as well as comments. Problems this will alleviate:

-users will have a way express that they feel a submission is egregiously off-topic or extremely redundant rather than leaving the off-repeated comment "This is Hacker News?" or "Here is a script to hide links with the word iPad" etc.

-Will improve the quality of submissions and prevent people from karma-fishing with linkbait titles on articles of little value.

-reduce multiple copies of the same story from sitting on the front page
Developing the core functionality is only 30% (or less) of the work, creating a finished product requires a lot of spit and polish!
According to their FAQ you can change it, but you have to change the name and remove the preamble entirely.
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It doesn't matter whether or not the original commentator asserted that reason or not, Facebook is a public corporation in the United States, it's not a private individual, it's not a private corporation, it's not Zuckerberg.

Public corporations in the United States are licensed for the purpose of maximizing shareholder value. This alone is not prima facie lassez faire, but the balancing regulatory framework for corporations is reasonably asserted as mostly lassez faire. (There really aren't any examples of 100% anything goes capitalism in the world.)

When Facebook makes a decision, it is to maximize business value, as in shareholder value. If a person makes a case for public corporation free will, I think it's pretty reasonable to respond with assumptions based on the actual nature of the entity we are talking about.

Which part is damaging to my credibility? Unpopular, perhaps, but lacking credibility?

Are you switching into attack mode, tptacek?

[Edit: Oops, I thought Facebook is public already. My bad, thanks philwelch for the catch, now that is damaging to my credibility ;-]
I'm all for exposing issues with Groupon, but does the entire blog post have to be "Groupon does this, but WE don't."

Point the finger, expose the flaws, and people will draw the connection that your company doesn't have these issues on their own.

Also just a note, we just signed a 'deal' today with LivingSocial and I'll report back here on our experience when it runs.
lol, the kid is doing it all wrong, he shouldn't need capital for anything. The tables should be made to order. All this will do is sink his business in inventory.
Twitter Fighting Pennsylvania Subpoena Seeking Names of 2 Tweeters
I also learned this the hard way.

I was still in high-school and it was one of my first programming gigs. Got screwed for about U$250, a small fortune for me at that time (IIRC about 3 times the monthly minimum wage in my country).

In a way it was good to have that experience early: it seems that most people don't learn that lesson unless they learn it the hard way.

Then I learned the importance of having written contracts for everything, and then later I learned that contracts can't solve the problem, only mitigate it. You have to select your clients, bill often, etc. But you have do it diplomatically, you can never suggest to your client that you think he'll possibly screw you.
I think if Microsoft had made a silent low power box with MCE on it and marketed it as a DVR they could have had this whole market. I still don't understand why I can't walk into retailers and see such things on the shelf. I don't understand why it isn't built into the standard xbox. They have a device - it's in the living room already and it's even already connected to the TV. But it doesn't run their DVR software. There's something very inexplicable about it all.
Well, nobody is forcing the merchants to sign up with Groupon instead of Tippr or Living social, there are enough competitors out there now that merchants can sign up with the company they want.
Copy imgur. Don't require a title, description, tags and all that. Don't even put it there, it just makes it seem too complicated. Copy imgur's flow exactly. Make it a simple front page. Give back a URL.

Don't bother with browse and all that, at least not until you've got a lot of recordings.

Change the URL. soundkey.com/key=so9m6u is lame, make it soundkey.com/so9m6u

No one needs an account. Don't even let people register yet.

Honestly though. I'd give up. People really want to upload videos and they really want to upload images. The number of people that want to record a sound is far far smaller.

This is not likely to ever be all that popular. I'd turn it into a much simpler site, then stop thinking about it. Chalk it up as good experience, and then work on something else.
Someone should tell him about kickstarter
I hope they reopen the tours at NUMMI.
it takes 16 steps to get from aphex twin to billy corgan.

http://labs.echonest.com/SixDegrees/?start=aphex+twin&en...
Ah, Altavista, once my chosen gateway to the world wide web.

Still live incidentally at www.altavista.com (and the shortcut for we in the know, www.av.com), but now, sadly, lacking those looming mountains that spoke of the journey your search would ignite.
No, they are not victims - they are patients. This "victims/non-victims" meme is just wrong, and it's toxic. Please don't spread it.
I only affirmed that Facebook is utility-like, not an actual monopoly or utility; likewise, that their action is unethical, not illegal.
I can't believe I'm getting into a discussion about this, but I noticed in the S-1 he actually is allotting $9,000 of it for marketing and general expenses. Only $3,500 is for labor and materials.

You know, this is such a simple S-1 that it would be a great first example for someone who is learning about the process. This is practically a lemonade stand.
I'm not sure if it's open source, but there's a command-line tool that came with my Mac that may also be on your machine to do unit conversions. It's called "units". Even if you don't want to call it directly, you may be able to use the conversion table files that are stored somewhere for it to use. As for calculations, if they are basic, interpreting the calculation as Ruby or Python code might work, though it risks the user entering something more dangerous that might need to be checked for.
an IPO for beer pong? he better be Sarbanes-Oxley compliant
Side note: it's interesting you were able to post that link. When I tried to submit that story, it was [dead]ed automatically. Perhaps submitting gawker articles is disallowed, but are okay in comments? (NB: that's an inquisitive question...I'm not bitter about a submission being [dead]ed!)
Not to mention he's entering a market that already has complete saturation of competitors. He'd do better making beer-tasting ping pong balls than manufacturing beer pong tables at this point.
Cool, so does this mean he can raise investment capital from non-accredited investors?

I filed my own C-corp in NY state (All the paperwork is boilerplate, there's just a $200 filing fee)... I wonder if SEC filing is reaching the same level of boilerplate where anyone can do it with standard forms?

If so, or if it's so easy a 19 year old beer pong enthusiast can do it, then why are there only about 8 or so IPO's per year?
"Facebook is a public corporation in the United States"

When did they IPO?
Seriously, the two articles are right next to each other

http://i.imgur.com/JSITF.gif

and people keep upvoting this one.
Craig Venter is the future (the intellectual entrepreneur)
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Toyota invests $50M in Tesla, will jointly reopen NUMMI plant
I think this (and its attendant media coverage) is great because it brings religious irrationality and violence to the attention of the non hacker mainstream media.

I understand why Muslims wouldn't want to draw Mohammed but insisting that non Muslims shouldn't draw Mohammed is insane. This would be like Buddhists insisting that since to them, meat eating is abhorrent, they ( or a "small minority" ) would feel offended enough to kill someone who did.

Now I am going to draw a Mohammed stick figure and put it up on my website. It is "Everybody draw Mohammed" day after all, no matter what the cowards at Facebook think. Lots of people don't friggin believe in the sanctity of this "prophet" or his religion so why should they abide by his mandates? All Religion should die and be some kind of fringe cult so the rest of us can live in peace. Hopefully in a few centuries.
The artificial dichotomy of "book smarts" vs. "street smarts" is a poisonous one.
I'm not sure if you're expecting a congratulatory note or not. I'm sure Steve Blank knew that people could find the identity if they really wanted to, and yet he chose not to share it. Having even a small hurdle to overcome means that the vast majority of people (most of whom don't need to know) would never really find out the identity of the bad VC.

Thus he can tell his story, and retain some civility...until someone comes along and is a bit too eager to show off his google-fu.
Wow, $9k for marketing. I hope this kid is a marketing whiz and has a helluva good product. Otherwise this is going to be a costly lesson.

Although to be fair, I've lost just as much as money if not more in my teenage entrepreneurial journey.
Where "religious argument" includes discussion of why free speech should be close to absolute, even on a service being operated by a for-profit entity.
Uh-oh! I thought it had already, I edited to correct, thanks. Now my rhetorical flair in the opening paragraph is all ruined! ;-)
Oh man, nice find, how did you get his myspace? Someone needs to document this story.
The longer it takes to learn a lesson the harder it will be when you do.
Created a group to protest the removal of the Everybody Draw Mohammed Day Group.

http://www.facebook.com/?ref=logo#!/group.php?gid=1227378910...

Join it! Promote it!
"If it was as easy to apt-get some package on to the mac" / "The initial hurdle to deployment is the hard one"

Far easier for the vast majority of users already. Download, move to Applications, done. Automatic updating via Sparkle. It ain't exactly rocket surgery.

As far as typical unixy tools, homebrew (http://github.com/mxcl/homebrew) does a pretty fantastic job.
On crafting a good personal character there are two words: convincingness and credibility. In any situation, you must always be convincing in what you do and say, and in a way that puts you in a good light without undermining your credibility.

This doesn't just mean "don't lie" or "don't get caught lying." It means that whatever courses of action you choose to take, you have to make sure that they are convincing and congruent with the environment. A magician is very convincing.

Things aren't always about facts but about emotions, what people see, or how things appear, and about the people you surround yourself with -- the people others will see, then proceed to judge you by -- and how you handle yourself in budding relationships. Don't be afraid to accept favors and give favors without the presumption of your favor being returned. Franklin has said something on this to the effect of "ask to borrow people's books, even though you don't intend on reading it."
On my N810, I can switch it off in the default browser as a what seems to be per-process setting. It takes three touches to toggle it from the main browsing screen. I don't know what it is on the N900, but I really doubt they'd downgrade it to a compile option.

Other browsers available on the platform might have different functionalities — in particular, the alpha/beta of Opera Mobile has click-to-Flash—like functionality.
That sounds like people being paid to exist
I am the Google-fu!

Specifically, he had his name and undergrad status at University of Nevada Las Vegas in the S1. That gave me his rodeo credentials; plus "beer pong" gave me the MySpace page which linked them together.
If they have zero experience, are they really a UX Designer?
But not his money, after all it is a public offering.
Google Latitude API
Why are stoves flat?
It's barbaric because it's pointless and invasive. You're worried I might commit a crime? I don't recall seeing tourism cited as the reason your prisons are overflowing.

But beyond that visas themselves are stupid. There is no humanity behind visas, just mindless and impersonal bureaucracy designed to protect us and our countries from nobody - they don't stop anyone with bad intentions, they don't stop anyone intending to stay illegally. All they do is artificially limit you whether it's in your exploration of a foreign culture or you're the founder of graphic.ly.

I travel a lot, I love the world and I love seeing and being a part of as much of it as I can afford to. But I hate visas.
Always look straight ahead when at the urinal.
I've installed some non-standard packages on the Mac and it was pretty tricky.

Not exactly 'move to applications'. And if some package is only available in source you're really in for a rough ride.

It's been a while though (about 2 years), possibly it's much easier now than it was then.

I use my mac so little now I've borrowed it to a friend here that does design. Too bad in a way because I really like the machine, it's so quiet compared to the pcs I use.
The important thing isn't a zillion people doing their own thing in their own place, it is being coordinated about standing up our rights. This is a great opportunity.
Luckily, I learned this hard lesson vicariously from a friend.
Last I checked, "victim" was the conventional term to apply to someone with a significant illness, e.g. "cholera victim." Patients are just the ones currently receiving medical attention for it.
Use of "consumer" as the default for a human being in our society is emblematic of everything that is wrong with it. Consumption is a natural part of normal life; it is not who we are. Every time I hear that word -- which is whenever I listen to media, approximately -- I think of pigs at the trough.
You could say "education" vs. "experience". I've seen company trained managers implode in tears on a sales floor, first week on the job.
As a Fremont resident, I cannot be happier!
I think a relevant question to ask is, has Apple just replaced one market for another with a lower profit margin?
... all of which stopped a fair while ago. IIANM you can root your Verizon Android phone if you want to.
When (I'm hoping it's 'when') this becomes stable I'm thinking a Mac port of this would make a lot of people happy. Despite Steve's fighting words I think most Mac users out there would prefer not to be second-class citizens on the web, and this could be a big step in that direction.

PS. Apologies for stealing your thunder there, Linux people, I just see the average Mac user wanting [a decent flash player] more than the average Linux user.
And visas are a total waste of time to apply for and get as well as of money.
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Postgres Switching to Git (PgCon Day1)