skysight-inc/HackerNews huggingface dataset:
The other big complexity is the self-similarity of the genome. To sequence, the genome is duplicated, then sharded physically into many overlapping tiles around an average length, each tile starting at a different position. Each sequence is determined in parallel, and then the shards have to be reassembled computationally (really, this is a post-sequencing process, but is critical to being able to call the result a "sequence" rather than a bag of reads).

If the genome in question contains a lot of regions that are similar to each other, the algorithms that do the assembly will get confused.
What if it doesn't show a specific application making requests? What if it chooses to not do that? How do we know?
Same in the Netherlands. You can expect to pay ~€5 per KM on short drives, the drivers are all foreigners who purely taxi because they get a huge tax cut on the Mercedes they buy and they are always extremely rude. And if they notice you're in a pinch, they'll try to completely price gouge you. Drunk guys want to get home? That's 50 bucks (100/2) for 30km..
There are regions with sparse coverage due to higher concentrations of C-G bases. This can make alignment results less reliable. Plasmids may interfere with alignment or need to be isolated out before or during library prep. And you want to detect and discard any members of the population with any evidence of cancer, genetic disease, etc.

And you need good population coverage. What's a normal variant? Newer methods propose a graph alignment instead of just trying to build a single sequence reference genome.
I wouldn't necessarily say that technology has cold calling obsolete. We sell a SaaS platform, and despite doing lots of online marketing, we still get a lot of business by having salespeople ring up companies who we think would benefit from using our software and pitching it to them.

Can't say it's a task that appeals to me, but it does seem to be fairly effective.
Question: Do you use an Android phone? Just saying.... you have much bigger problems on this kind of devices.
Yes mostly the number of base pairs. Large repeats can also cause issues finishing a genome.
It's too bad Atom isn't as fast or faster than Sublime Text 3. I just can't go back to Sublime Text now, Atom is good enough.
Solving real world data problems with Jerakia
Did you forget the sarcasm tag?
I've had the Herman Miller Mirra chair since December 2011 and could not be happier with it. Much better than the SteelCase Leap Chair it replaced and in my personal opinion it's more comfortable than the Aeron chair.
Google Web/Search History Disable Does Nothing (2014)
How did you get around not having live.com for MS Office? I've got the retail box of 2016 for Mac (not the 365 one) and it still required me to make one :(

At every launch, it connects to login.live.com and live.com.akadns.net.
Oh totally. What's weird is their organic milks expiration dates are really far out compared to other brands. Kind of insane actually.
> both "commercial" and "federal" launch prices, as the first are driven by market, while second are more driven by actual costs.

I.e. "federal" prices are likely subsidized. What's the point using them?
I'm using Visual Studio Code and absolutely loving it. If you document your code (JSDoc) etc, the IntelliSense is absolutely incredible. There's a vibrant plugin community, the only flaws I have found so far:

* You can't add multiple folders to a project. This is fucking irritating.
* The git plugin doesn't work on subfolders - IE because of problem number one, I put a group of (say, microservices) into a parent folder and add that, which in turn breaks the Git plugin.

If you can ignore those things it's bloody brilliant. Obviously after you've added a bunch of extensions and stuff to spruce it up.

It feels faster than Atom, too.
> There is no end to the... creativity of CSV file authors.

Eh, commas and new lines are common, let's use pipes. and count fields.

:'(
Extroverts can also research, listen and adapt.
"hey i have 5 ultimate frisbee frisbees with super mario bros. art on it. want one? $25 bucks to my paypal"

example taken from noah kagan explaining the process. if you manage to collect the cash, you order the frisbees from the vendor you found. if you dont sell 5, just ship the money back. the example is deliberately simple but you can apply that to anythign. you have a business idea, sell the result of the business. if nobody wants it, dont build it.

i dont know go fund me, but if you run a kickstarter, its basically the same thing. you say you need an amount of X dollars to be able to deliver. if its not met, just return the money. the fact that people on kickstarter are idiots and dont deliver after collecting money is another story.
I have the same thing with system monitors. So many processes for which I have no idea if they're legit.
4 Cloud Tools That Will Help Your Marketing Team Up Their Productivity in 2017
not related to vim, but try Visual Studio code. Once you personalize its shortcut key bindings (which everyone I know does), it's way better IDE than sublime/atom/etc. It has code definition 'peeking' (staying on the same file while 'peeking' on definition), reference peeking, renaming, etc.
Visual Studio Code?
Le Debrief – Episode 5
For a long time in Spain fines for polluting were lower than the cost of actually fixing the issue. As you can expect factories continued polluting. Then that changes to bigger fines or even to stop the factory until the problems were fixed. In no time factories hired people to fix the problems and to make sure that it didn't happen again.

If a company is allowed to break an agreement with no consequences. How do we expect it to abide to the rules?

> As a society, are we going to allow companies to lie and deceive in the name of "disruption"?

I dont' see any disruption in Uber business model. They just offer a service without paying the proper taxes that other companies (taxi) have to pay, and without paying minimum wage or having other guarantees for the employees. That is as old as the rule of law and taxes have existed, the only novelty is that they use an app to do so. And apps have been already out for a while.
In Denver the taxi's are horrible - half the time you smell puke or some horrible odor, the other half you have to wait an hour to just get a ride. I'm not saying I like Uber as a company, nor what they did to drivers, but they (as well as others like Lyft) have created a fresh fast way to get around and it costs the same as a taxi most of the time. It's hard to not flock to that.
Being a prosecutor and having compassion are largely incompatible. If you can't smother that part of yourself, you get fed up with putting people in prison--essentially for being poor--and quit in disgust.

That creates a vicious cycle, wherein the cruelty of disproportionately severe prosecutions drives out those who would not pursue them. When the people with the most convictions and longest sentences for the worst offenses get promoted, whether the criminals deserved them or not, it affects the workplace culture.

Perhaps it would be better to force the state's criminal-court attorneys to spend equal time as prosecutors and as public defenders, and promote based on criteria other than win-loss ratio.
One of the approaches used on long-distance buses is "track head position and angle." If you're "looking" into your lap or into the ceiling while driving, that's a fairly reliable signal that something is wrong, never mind how you're holding the steering wheel.
I believe this is the same crack that we discussed a couple weeks back: https://news.ycombinator.com/item?id=13365211
Lunar Logic: 25 people is enough
If you're an introvert like me and want to explore sales more I highly recommend "The Secret of Selling Anything" by Harry Browne Check out this book on Goodreads: The Secret of Selling Anything https://www.goodreads.com/book/show/17622965-the-secret-of-s...

He lays out the sales process in a very logical manner that I have not seen elsewhere. Before I read this book I too had the impression that sales was about manipulation and this book completely changed my view on it.
> you have much bigger problems on this kind of devices.

Which might be true, but two wrongs do not make one right. I.e., leaking data on mobile devices does not make leaking data on laptop ok.
Yeah, the missing context is that we are talking about vectors where GitHub would not be sanitizing the input correctly. In other words, vectors that traditionally resulted in XSS. We do exactly as you say in places where we expect user controlled input. For example, all issue/pull request comments are Markdown. And, for security, we go to great lengths to ensure that we only accept a subset of HTML that is safe AND that the resulting HTML is well formed. But, as history has shown, XSS is more or less unavoidable. There are just too many places where it can occur for any application to 100% avoid it. This is at the heart of CSP. Given that history has shown that XSS was unavoidable, the idea was to add a browser feature as a second line of defense. So, the article is written from the perspective that traditional XSS is neutered (the whole "scripting" bit of XSS is gone) using CSP. So, given that, what might an attacker be able to do without injecting any JavaScript? This is the origin of "scriptless attacks". Dangling markup is the most popular technique for exploiting a scriptless attack. So, it isn't that GitHub would be failing to create well formed HTML. It would be a scenario where an attacker would traditionally like to have injected a `<script>` tag, but is no longer able, so they must go to the next best thing...dangling markup.
Yes but what is ne and what is a wegg?
oh maybe you have luck. Just found this: mobiwol http://android.stackexchange.com/a/40926/57180
To misuse Cunningham's Law:

System Settings > Security & Privacy > Files & Applications

Then choose what document types (if any) to show in dash search.

That should solve #3 perfectly.
No, but you'd need a better Faraday cage than a microwave.
https://www.owasp.org/index.php/Main_Page
Why You Should Learn ASP.NET Core
What does Atom bring to the party that Sublime Text 3 doesn't?

All I can of (off the top of my head) is slower and chews more memory but is open source.
> Customers hate being cajoled or manipulated into buying something they don't want.

I, personally, even hate when I actually buy something that I wanted, but was pressed by the seller at the same time. It takes away my joy of buying, of deciding, of choosing.
Really depends. If you invested around 3 years of your life, and took significant investment from people, and all your employees had to be laid off along with yourself, you probably would want to take a break and have nothing to do with business for a while.

Moreover, if you have no money left, you will probably want to find a job, otherwise you will become homeless.

But if you still have some money, and it was only just a short sprint of several months with just you and your co-founder, it's good to move on to the next idea.
> Doesn't work with `self` because that would be implicit again, though.

AFAIK it doesn't work on self because the [&[mut ]]self parameter is more or less a keyword determining ownership interaction with the call subject.

The UFCS RFC would have made it sugar for `self: [&[mut ]]Self` (IIRC) but I believe that floundered.
Ask HN: Are most leaders big on ego and short on competence?
When I was straight out of school I assumed that people in positions of leadership were there due to their hard work, knowledge and intelligence. After over 20 years of professional work - often as consultant where I moved between many organizations - a pattern seemed to emerge. Majority of leadership positions are occupied by people with oversized egos who are lacking in professional skills and knowledge, but they got there by being loud bullies with sharp elbows pushing aside more competent, but gentle humans. Is it only me who thinks that?
Absolutely. Every now and then I have to click a few buttons, but that's OK. I like knowing what installed programs are doing.
My flaws:

1) Uses Chrome's font renderer - it looks terrible on Windows

2) Indent = Tab size

3) Themes can't properly customize some key on-screen assets

4) No macro recording/playback

5) Can't edit enormous files

Other than that the add-on ecosystem can be a bit fiddly, and you won't find syntax highlighting for more oddball things that you'd 100% find for vim or Emacs.

Oh, and sometimes it ends up using 100% of the CPU in the V8 GC. Might be add-on related.
We don't need to DO anything to achieve Doomsday, we need to fail to do enough, in time to prevent the point of no return. I'd say we're right on track.
Exercise Ball.

I have a LEAP chair which is broken. It is much better than the overhyped Aeron. In theory the LEAP has a lifetime warrantee but practically the nearest Steelcase dealer who is 60 miles away won't return my phone calls.
Besides "return", C/C++ doesn't have a particular word that stands out. Probably because you just write write things. eg you don't put "function" in front of a function.
A lot of older parts in Python inherit the naming style common in C, which always seems to me they have OCD to shorten everything, e.g. ls for list, mk for make. Newer Python parts are more “healthy” in this regard. But this also results in some wierd inconsistencies like mkdir vs makedirs.
Most of the teachers at my daughters' school do this, or at least they use a cardboard box on the desk at the front. All phones in there at the start, pick them up on the way out. Anyone caught taking a sneaky peak at a phone in class gets detention.
It's a similar construction to "fiscal conservative" or "social liberal", i.e. in this case people who had liberal views on racial issues in the 1940s-70s debate over the civil-rights movement. I think this particular phrase is a bit idiosyncratic to Gottschalk, though. It's intended to give her a concise phrase that includes social liberals, conservatives who had liberal views on civil rights (common among northern conservatives at the time), etc., rather than having to constantly repeat a construction like "those who had liberal views on racial issues".
I was already doing backend work for them and they asked if I knew anyone to do the front-end.
Also only with Core M processors I think
Elite: Dangerous
For a company like Tesla, I dearly hope they don't think this way. If so it would mean everything they talked about was marketing drivel (the safety of the car frame etc). So far Musk felt honest with most of his design claims. Unlike lone SDV hackers on github for instance.
This is a weak argument and frankly the introvert extrovert juxtaposition is trite at this point. The article sounds like frustrated happy hour conjecture by somebody who has never actually worked in sales. Cherry picks a lot in order to make its case. Yes selling takes a lot more than a smile and persistence. But why can't extroverts be good at research and listening? What if you're driven and enjoy a good balance of quiet time and social time? It’s rare that anyone is this binary and thinking that way is ignorant and kind of rude. You’re essentially saying “extroverts are dumb they don’t know as much as they should”. Come on. And also there will always be some form of cold calling in sales. The point is not literally the call, its finding a way to introduce yourself to a complete stranger and create a relationship. Whether thats through email, the phone, or walking up to someone at a conference, there will always be some version of this. If you’re relying on landing pages and conversion optimization to sell at all scales of software, someone else is going to beat you by knowing a guy who knows the CTO, or being the nephew of a VP, or having the guts to walk up to someone at an event.

Theres obviously a lot to learn from archetypal human behavior, but when it’s presented like this it just falls flat.
Why I love clojure. Pt2
It's zero sum, that's why Uber is able to do what they do. The drivers get shafted so you can have a cheap ride and Uber can be a billion dollar company.
Every good salesman I've ever met has either been an extrovert, or acted the part to a tee.

As an anecdote, my heavily extroverted brother in law is the best salesman I know. He went door-to-door in San Diego selling pest removal services. He would net over $80,000 in commissions over a summer.

Maybe it's different in B2B, but in B2C the best salesmen I've seen have always been extroverts.
> KSP, in its unmodded state, isn't very demanding GPU-wise, so as long as your CPU isn't 20 years old, it should run fine.

In fact, it runs acceptable on low-medium settings on my 2014MBP with integrated Intel Iris(!) graphics.
I recently got a new Surface Pro 3 for 450 on Ebay and love it, even runs linux well.
I second this opinion. There are for example lots of people who are happy with older Lenovo models. Performance wise you don't need to loose that much, since the Intel CPUs are not getting that much faster. Pick up some good model (for example on Lenovo side look at X2x0 or the T4x0 (where x=2,3,4,5,6) models) and swap HDD with some reasonably priced SSD and put in max memory.
I have updated the article to link out and define the first reference of CSP.
How long is your runway? Try to get your projects to revenue as soon as possible. If you can, perhaps you can do consulting work on the side to slow the burn.
hell, I knew US is a effed up police state these days, but even a possibility of life for 3 times driving drunk? that's not western democracy, that's 3rd world fascist dictatorship in a hardcore flavor (FYI, I rarely drink and if yes its max few beers/wine only, would never drive under influence)

maybe if you are living daily in such a broken environment it starts to feel more normal, but seriously guys... get a grip and try to come up with something that actually solves problems and not just destroys lives permanently.

I don't want to travel to US for same reasons I don't travel to Afghanistan or South Sudan - some good people, but messed up system and you don't want to accidentally see the darker side of it
One source is the satellite radar of the Sahara for instance - all the hidden roads, rivers and towns swallowed by the desert.

Then the American Southwest was grasslands, until gold rush and westward expansion including cattle and sheep, resulting in overgrazing and irreversible changes.

The Gobi was widely inhabited in prehistoric times. People arrived and wham! desert. Its still expanding today, one of the fastest-growing deserts in the world. Because, people.

The Namib is indeed old. Its also almost the smallest desert - #25 on a list of 27 worldwide. So lets grant an exception there.
I think the internet will virtually elimate sales for the generation that grew up with Amazon. I know it has for me, I consider any product that forces me to call someone for a quote likely too expensive for my needs.
ProtonMail announced that its Tor Hidden Service is online
I've been scammed by taxis on multiple occasions. Never been scammed by an Uber driver, and I know exactly what I'm paying before I get in.
I drove for them for a while. This is from an old email in 2014, they loved to ignore the costs drivers incur, and slyly referred to earnings instead of profit:

"NEW UBERX RATES

Uber’s goal is to ensure strong driver earnings and offer the best value to riders. Maintaining low prices will keep demand high into August and September, and help you do more trips during this time. From this promotion, we have learned that a 20% price cut will keep driver earnings higher than May peaks and keep demand at record levels. We have seen similar effects in other cities where lower rates increase trips and increase driver earnings.

In short:

- Average driver earnings will be higher than May levels
- Uber’s 25% promotion to riders will end
- Prices will be reduced by 20% for both riders and drivers"
its foolish to believe that applicants should have the right to hide their expectations indefinitely but expect employers to broadcast them to the world.

if you dont want asymmetry in the negotiation process, be a good sport.
I switched to GuixSD for the same reason.
Introversion-extroversion probably is an interesting axis for analyzing socialization, but I wonder if enough people are really far enough from the center for analyses like this one to mean anything.
I think that depends on the length getAge(). If it's 3 lines, 'p' probably is fine. If it's 200 -- which, perhaps it shouldn't be but that's another issue -- then person is probably a better choice because you may lose the original context as you scan the method.

Also in Java if you use intellij then you'll probably get 'person' as an autocomplete, which actually makes it roughly as easy to type out as 'p', (and a better choice if your entire team has standardized on intellij.)
1b) Electron is horrible bloat. Sublime uses 70 (idle) to 250 (lots of tabs) mb. VS Code and Atom both use 200-300Mb even when idling.
Komodo Edit has all this features and more, and it's OSS project... also has a vim-compatibility mode, so you can train your vim skills in IDE-like environment, it makes the learning curve easier on you...
I went through 10+ years of schooling where I could not immediately contact my parents and I and many others survived just fine. I think that school aged children having mobile devices probably does more harm than good when you factor in cyber bullying. Has there been an occasion where your child has had to contact you in an emergency?

For everyone who is misinterpreting this statement. I am not suggesting that jamming phone signals is acceptable. It isn't for the very reasons provided to the headteacher in the article. What I am suggesting is that children do not need access to their devices during lesson time, at which point the children are being supervised by a responsible adult (the teacher) who is able to contact emergency services or parents in the event of an emergency. Requiring students to hand in and retrieve their mobile phones from teachers at the start and end of a lesson is an entirely reasonable solution to the problem being faced by this (and probably many others) school.
So you don't have a product built already?

Your plan reads as if:
quit job --> make product --> get rich

Why not build the product at night to get an MVP, maybe take some vacation days if necessary to build and/or sell it to prospects, make some money and then quit your job?

You only have a few thousand which seems like you are banking on your idea taking off right away and I can tell you from experience it rarely does.
The schools have no landlines and/or public phones, is that what you're saying?
You missed Xylella fastidiosa. It was sequenced in 2000's
..should have been called "SHIT."
Use Terraform to provision some virtual machines, load balancers, bastion host, vpc, etc. https://news.ycombinator.com/item?id=13436415

Use Docker to setup development and production environments for a sample Flask application with CI/CD. https://news.ycombinator.com/item?id=13436452
Android Things Basics: Measure Distance with Ultrasonic Sensor
I am definitely old school, but if this (IMHO senseless) idea of reading "://" as "ill" would go on, a few sites might be read "the wrong way", as an example ;) silly combinator:

https://ycombinator.com

and silly ahoo.com:

https://yahoo.com

No, wait, the latter one doesn't sound too bad...
No, you're not alone. I spent 17 years working in investment banks. The trend you identify is quite pronounced in those organisations. My response has been to become highly cynical, and very demanding when negotiating compensation.
Only ever used puppet during my time there, fwiw
Watch network traffic from a box with LS installed.