skysight-inc/HackerNews huggingface dataset:
Let's say you had such an organism.

Naturally, all the yeast individuals in your population have slight genetic variations. Maybe millions of them. Most have your plasmid to make X.

Due to natural selection, the competing priority—let's call it the "Y" product—is reproducing * surviving as much as possible. The yeast genes that make the yeast reproduce as much as possible and survive as well as possible will eventually be the largest population in your reactor.

So if X doesn't also achieve Y, the only thing that will be left in your reactor is a population that achieves Y.

The worst thing (which is true most of the time) is that achieving X is opposed to Y. Processing some chemical in the media that doesn't translate to food for the organism is wasted metabolic resources. So for most applications you can think of, your X population will die or reproduce away its X genes.

There's nothing you can parameterize to fix this! Like Y will happen regardless of what temperatures you use, or what media you use, or how much oxygen you give the reactor. By virtue of growing something, you're optimizing for Y. Either design X to also achieve Y, or fail. Evolution is opposed to you, not on your side!

In practice today, we don't understand the biological systems design well enough to make X also achieve Y. So what happens is you grow the yeast until you have a population with maximum metabolic efficiency (i.e., maximally achieves Y), and THEN modify the yeast to do X. It dies quickly, and your left with a little bit of product. This works, but it's not viable.
Yes, a quick look at the late Roman Republic period makes our modern politics look down right polite and restrained. Certainly all the same themes as we see in modern politics, but turned up several levels in intensity.
I don't think that you understood my comment very well.

So, look, if you don't believe that climate change will be disastrous, then you're perfectly within reason to say that geoengineering is a really bad idea. The beef that people have with you will not be that you're wrong to be opposed to geoengineering, their beef will be that you're wrong to think that climate change is no big deal. I'm not here to fight that fight. If that's your position, fine.

If you DO think that climate change is a big deal (and by big deal, I mean you think it's somewhere between "likely to stall all economic growth worldwide for centuries" and "likely to kill all of humanity"), then it's kind of hard to imagine what worse consequences geoengineering could possibly have.

And particularly, if you do think that climate change is a big deal (as described above), there aren't a lot of very realistic options besides geoengineering. It may be that even if we stopped ALL carbon emissions RIGHT NOW, we'd still have really bad climate change. And obviously, realistically, we just won't stop all carbon emissions now. We won't stop all carbon emissions in a decade, or two decades, or three. I am prepared to argue with you if you imagine that we can stop all carbon emissions now.

The only fourth way I can imagine is that someone might somewhat reasonably believe that in the near future, technological advance will get us out of this. That we'll discover some way to do massive carbon-less power generation at very low cost and/or that we'll discover an obviously unproblematic way to do carbon sequestration on enormous scale. I will say that if you assign a high probability of disastrous climate change, I don't see how you'd assign a similarly high probability of those exact technological advances. In fact, I might call such precise foresight... hubris.
It also eats time like crazy and I find switching between development and marketing mindsets frustrating.
That's the Koala-type. The first iteration were modified Lexus', and self-driving in highways is much easier than in cities, so it's attacked first.
Yes. Having moved from a country that lacks good public transport to one that does some years ago I had exactly the same experience. People tend to judge from experience (and why would you not) and I'm guessing many Americans simply have not experienced the freedom that you get by being car-free.
We do version API. Everything is done by content type. You can ask for a "vnd.something.something.json+v1" "+v2" etc...you still want to update everything on the older version so you don't want to maintain that crap forever.

Then there's the splunk searches you have to run to make sure all your consumers are onto the new version .. and that "What the hell is that IP and why is it using v1? Why does this API key not have a name on it?!"
I have Bose QC35s and they can be simultaneously connected (not just paired) to two devices at the same time. They can be paired to more, and you can cycle through paired devices with a switch on the headphones or use the iPhone app to select which two devices you want connected.

I almost always have both my Macbook Pro an iPhone connected. The switch from listening to music from the laptop to the iPhone (such as when I leave the office and get on the bus) is seamless. Simply stop playing music on the laptop and start playing music on the phone. I highly recommend them.
while I don't disagree with your premise, I think a more generous conclusion is that the angular team has learned from the 1->2 disaster, and has decided to focus on the long term, even if that means causing more headaches in the short term.

still, I'm glad I moved to vue.
Estimated remaining runtime removed in macOS 10.12.2
It's not bad. It's got some not-entirely-awful metaprogramming features; a while back I got interested in it and wrote a 'modern' macro package proof-of-concept for it:

http://cowlark.com/meta

Example input follows. Defining a paragraph style in meta:

.STYLE TITLE
. FONT SANS
. FACE B
. FONTSIZE 30
. ALIGNMENT CENTER
./STYLE

...and using it:

.TITLE
The meta macro package
./TITLE

This is a very simple, noddy example of how to use the meta
macro package. It's not intended to be a reference (there currently isn't one).

But the core language is kinda horrible, needing a really hacky implementation, and you can't define inline macros --- the \fB and \fP above are built-ins. Macro invocations have to start on new lines. In fact, this isn't a bad limitation in practice for anything even slightly heavyweight, but for italics, bold and underline it's still nice to have inline markup.
The only thing I know about public key encryption in PHP is that it sounds like a terrible idea. Am I wrong?
Or, wait, what if we made the car really long and put in even more passengers per driver? It might even have a pre-determined schedule and be pretty cheap?
Meanwhile in Canada, we have approximately 3 months before legislation is introduced to legalize. It's a great time to be up north.
Sure! If you can provide an example of a meaningful conversation where the claims being made are not falsifiable, then it would falsify that statement.
Building a modern database using LLVM (2013) [pdf]
Yes, but what I meant was M&A is no longer a mechanism of becoming a monopoly at least in the tech world. Interestingly, I can't even think of one big acquisition in tech (excluding cable/utilities) that led to a monopoly as a result.
How reducing software config can propel all source code ecosystems
Eh, they'll pair trivially to other Apple devices (which ... NFC assisted pairing is not new).

It's months late, it's still not here yet, AND there's a "big" warning on the page that even when it is here it will only be in limited quantities and that prospective buyers are "advised" to check online for stocking levels... very un-Apple.
I feel your enthusiasm but I think your message will be a little off putting for new users. Personally I've been using emacs for about 15 years and would have no trouble sitting down at a fresh install and using it. I use all the default keys. Most of my customizations are in relation to org mode or custom applications I've written in emacs lisp. While I'd say emacs is very configurable, it's certainly not a requirement that you configure it for yourself before it is useful.
There's vTime, although it's primarily focused on mobile VR for now.

https://vtime.net/
The Acetone–butanol–ethanol process:

https://en.wikipedia.org/wiki/Acetone%E2%80%93butanol%E2%80%...

Obsoleted by cheaper petrochemical processes, but there's renewed interest now that environmental considerations are getting more attention, so maybe it will return to commercial use some day.
I'm getting a Bad Request no matter what I try. Anyone have an alternate link?
But your networked API is language agnostic, your library is not.

It depends but microservices are in many cases better where your application is large. Examples: AWS, Uber.

Monolith is better if your application smaller and cover just single problem. Examples: Slack, Trello, Jira
The notification to targeted individuals was presumably after Google had successfully fought the gag order.
Disclaimer up front: I work for GM, but not on vehicle development.

For #1, what would you do? Ship a much simpler product or ship a worse product?

In the current system Tier 1 supplier can concentrate expertise in a single area and spread development costs across many OEMs. A single OEM cannot effectively compete with this cost structure.

Tesla is notable for many things; one of them being its vertical integration. So far Tesla has been able to compete by both building simple cars (excluding the X, which is another story entirely) and charging quite a lot of money. They have also had serious quality issues, probably relating to their vertical integration. These quality issues may be resolved, but by that time either they or their competitors will have developed a new product, and then they will have to go through the development and refinement cycle again, at huge cost.

Regarding #2: the iPhone came out in 2007. Since then, there have been about 7 development cycles. For most automobile platforms there have been 3 or fewer development cycles since 2007. Before the iPhone, there was no real concept of remote update of mobile devices.

Automakers have caught onto the trend and you will see more mainstream OEMs doing remote updates pretty soon.
Got any info on what "too old" means here, I thought that glibc was supposed to claim ABI compatibility pretty broadly, or is there some specific regression/bug you're working around?

Edit: reading my message back I came off as impolite, sorry - genuinely curious, I've had the same breakage myself, and we started using Skype in lieu.
How about protocol buffers and content negotiation? Your pipe figures out a proto that program a can emit and program b can consume.

ls ->
repeated FileDescriptor files;
| repeated string names;

Where FileDescriptor is whatever it needs to be, has all the info ls -l does. You have a heirarchy of outputs: if the next takes FileDescriptors, you give it FileDescriptors, if it doesn't you give it strings.

What would go to stdout goes through a toString filter.
Have you ever had an earplug that fell out after 5 minutes?

The main reason earphones fall out of your ears is the wires. Most existing wireless earphones have some sort of wire attached to them. They're called "wireless" but that's technically not true because they do have wires, and these wires are what pulls the earphones out of your ear. It's physics.
uh huh. and just what is the definition of urban area?
Yeah Ryzen looks like a big win, however it's been the entry level i7's that have been the sweet spot for gaming, offering fewer cores that can be clocked from 4.5 to 5+GHz quite easily. Coupled with the current paradigm where most games don't scale beyond 4 cores much at all, gamers haven't really wanted the 6900k anyway. Long term Ryzen will continue to become more useful as GameDevs learn how to make better use of cores, but I don't see the need to replace my 5 year old 2600K just yet.
How does "spread out demand" work out with "people need to work 9-5"?

As for "much smaller cars most of the time": not if you want to maintain the current safety level while also being able to travel faster than 20 mph.
Red herring. It doesn't need to be perfect; it needs to handle an infinite number of edge cases. Humans can, machines cannot.
Properly encoded MP3s are sonically indistinguishable in blind tests from FLAC, so I'm not sure what you're referencing.
Yeah, you're probably right. I was sort of implying "with the understanding it's unlikely any of the IDE makers are going to do this, it would be nice to have the common code separate so a plugin wrapper is easy".

Something along those lines.
This would also impose an undue risk for human drivers.
John Carmack has done extensive work on the Gear VR. Here's a fascinating talk from 2015: https://www.youtube.com/watch?v=MB_u3FvUTQc
Localization process for Ruby on Rails
I think this is hilarious, even as someone who owns multiple Apple devices. "This is revolutionary. Nothing else does anything like this." "These do." "Well they cost more!", or "doesn't look as cool". Moving goalposts.

And eh, I realize that Apple almost never goes below MSRP/list, but don't act like the "after $50 off" is some special promotion. It's not a rebate, even an instant one, just 'cheaper than list'.
Transition adviser Peter Thiel could directly profit from mass deportations
Boy oh boy, I'd love to see this data correlated with which parts of the country practice comprehensive sex ed vs abstinence only (mis)education.
Not necessarily. You could equally argue that self-driving cars will be more popular among bad drivers.
Distancing yourself from Palmer Luckey is probably a good move. Distancing yourself from Oculus is probably a good move too.
That's not an Apple issue -- Bluetooth doesn't support that. I've never seen any Bluetooth device that can be paired to multiple devices at one time without having some type of device switcher button.
This website prints a lot of bullshit, though.
I wonder how the heft of larger PR companies fits with #3 “ Sourcing Mass Media News“[0]

--
[0]: https://en.wikipedia.org/wiki/Manufacturing_Consent#Five_fil...
I think this is a bit to one side of the question. Where government is doing the regulating, then surely the government itself is a state actor and must not infringe constitutional rights or be a party to same. You can argue it doesn't have any business calling anything a public utility, but that would be a different argument.
In my opinion, I'd say pull out troff if you're thinking about making a PDF, or if you want tables or equations (see http://www.troff.org/prog.html). Personally, I mostly use markdown when I want to generate some HTML but don't feel like typing tags by hand, or just as a sort of "style guideline" when writing text files.
I missed the mention to 3GHz lock, did they mention it on the live feed or to journalists ?
> They may have more cache or more cores, which might speed up some programs. But otherwise, they're the same.

It's like saying that mercedes with 2.0 engine is the same as 65 AMG. So writing that they are the same is like writing that every car is the same because they all drive.

You do not overclock in 99.99% cases Xeon server cpus.
You do not buy 12 core xeon to use one core, don't you? of course Xeon is faster for the use case you are buying it. A LOT faster in many cases than what you called "regular" chips. You are writing about home use cases from what I see and Xeon series is mainly for server use.
Right. I meant one of the published NSLs where "the targeted individuals have been notified", not the unpublished ones.
I think if you are not capable of designing a decent API you won't be able to design good microservices either. Both require some level of competence and discipline.
If you think that Fantasy is just for entertainment and imagination, you're giving the genre short shrift. Imagining the world as different than it is has tons of philosophical implications that apply directly to our experiences of our modern world.

Think about how The First Law series is different than Lord of the Rings. Now think about how our relationships and trust in those in authority have changed in between the publications of those two series.

Fantasy is about the world we're living in right now and our hopes and dreams for it.
It's mostly because of the money. Relational is still a great type of database and I'm sure Oracle is great. But I haven't worked with many companies that could afford Oracle very easily if at all.

I also wouldn't make a generic database recommendation :)
UNIX isn't dominant in the areas you mention now either (no, Android isn't UNIX). It has a niche among free software users and in networking devices but it is not common in other areas.

I.e. your "decades of useful outcomes" argument doesn't favor the point you are making because the opposite philosophy (a more verbose userland) has many times more "useful outcomes". Therefore, according to your own logic (which I don't subscribe to because I think popularity is a useless measure of sound design) you "should stop and ask yourself whether it's just a matter of taste on your side or, even more likely, of ignorance."
Byte order marks are wrong and not part of 'clean' 8-bit handling.

All applications and operating systems should assume files WITHOUT a BOM are either ASCII, or the superset there of, UTF-8.

Please remember to say WHY you disagree if you do.
It's called an Apple Watch.

I sync a playlist of my music from my 6S onto my Apple Watch rev. 1 and use a pair of beats solo 3. Works daaaaandy.

The Apple Watch is far, far too goddamn expensive, though. Let's get it down to at least $199, guys, and don't force us to pair an iPhone with it. It's what the iPod Nano turned into. Why is it so much more expensive?

If people could just buy an Apple Watch, it could convince them to buy further into the Apple ecosystem, in the same way as the iPod did (but obviously not to such a scale).
Actually they do. What's "magical" and "reinvented" is the fact that the AirPods seamlessly switch to whatever device you're currently using, so you can switch between your desktop, laptop, iPhone, and iPad without having to actually do anything to trigger the switch. In addition, it automatically pauses your music when you take your AirPods out of your ears (and resumes it if you put them back in).
You'll see the same problems of short runtime. All those processes are causing the CPU and hardware to wake up more frequently, tanking your battery life.
You mean Trumps wet dream, Palantir? What a perfect vessel for public/private cooperative actions! I'm sure his buddy Pete would give him a huge referral.
Looks like these researchers are trying to make a network more adaptive, I think that deleting nodes would only make them worse at the current task they're being trained on as well as worse on the tasks they're being adapted to.

You could train a model using neurogenesis to increase its accuracy, and then use distillation to train a smaller network to comparable accuracy.

But these are two very different, but complementary, problems.
It will depend on how well they'll be able to push the CPU in 4 core mode.

If they can't reach at least 4ghz it wouldn't matter.

Games are not optimized well beyound 3-4 cores these days I can disable 2-3 cores on my 6 core CPU and maybe lose 5% fps in CPU intensive games.

Intel can push their clocks pretty darn high especially with OC which now comes out of the box with every enthusiast grade motherboard.

If you end up having a 3.4ghz part going against a 4.5ghz part the 4 extra cores might not matter.

Even in professional use cases adobe doesn't scale above 4 threads like at all and many video encoders also don't scale some even don't scale beyond 2.

The only thing that really scales well universally is 3D rendering.
> will nullify the benefits of owning a car

Except I like owning my car. I can take it where I want. When I need it, I have it. I can leave my stuff in it if I want to (e.g. if I decide to go to the park for the day I can leave my coat in the car if it is warm). If it's pouring rain I don't have to wait, I can just get in it and go.
Iribe is thought to be worth $2bn. He doesn't need CEO money, he needs something that he's passionate about.
The funny thing is that that's where the market is sort of heading now.
Over ear headphones are better for your ears and don't have the issue of falling out. They are bulkier, though, and can get sweaty in summer (in Australia at least, might not have the same issue in Canada)
They sell metrics, this blog post has us talking. This is a blog post, a PR piece, not a news paper story.

Source metrics are the new panopticon of Software is Eating the World.
But my concern is about how they are scheduling breaking changes to occur so frequently, and almost two years in advance! Why induce that kind of headache over and over so regularly that the short-term issues become a long-term software maintenance burden?

I cannot imagine working on a software project where I'd want to plan out four distinct breaking change updates. I simply cannot prognosticate my needs that well, nor chessmaster so deeply that I wouldn't just do it in one bigger change. If they're anything like me, that means they're committing to inducing the hassle _without even knowing what the payoff is_!
Building a Machine Learning Bot to Play Facebook Messenger Games
I wrote my cv/resume in troff (groff), not so long ago (this millenium)

Didn't have Word, didn't want to learn LaTeX, printed html looked worse.
How will getting married before the end of the year impact this year's taxes?
I'll definitely grant you that. A shared pairing database would be nice.

Hopefully it's implemented well. My Text Message Forwarding still lists:

- iPhone

- iPhone (2)

- iPhone (3)

- iPhone (4)

- iPad

- iPad (2)

etc, et al. Note that I don't own four iPhones, I've just upgraded over time. I have to play a guessing game as to "Which MacBook Pro is the one sitting in front of me?"
On point 2, a lot of startups run that way to their own detriment.

The other cultural and pay issues seem a bigger deal to me, if true. So many of the best people I've met over the 10+ years in the valley care about things other than owning a home, for example.

Owning a home is nice but it can't be emphasized enough that their heart was in the work, and everything else followed.

I understand that that attitude may be one of privilege but it is what it is.

What is tech culture — at least the bits that other people want to replicate? It's about being at the edges, pushing what's possible. Or the value-add, if you're an economist. :P It's worth noting that even in the Bay Area, it's just a minority of the scene that truly aspires to this ideal. There's a lot of hanger-ons, even here. What's different about the Bay Area is that non-conformism allowed those weirdos to actually lead.
Yes, but they don't necessarily need to own them. They could call a ride from a lot 10 minutes away whenever they need one.
> A fully autonomous car's utilization rate can be close to 100

So if every car is almost always at 100% how am I going to be able to instantly get a car on demand from my suburban mcmansion?
This idea is at least partially in use with regularisation and dropout. The difference at least with dropout is that the "killed" neurons are then massaged back into the network in order become useful again.
Do people not set up the room 15 minutes before the session starts just to sort out those kinds of issues? That way it's only 15 man-minutes rather than 15*n man-minutes. Seems unprofessional.
Yea so ? Harping on the 2% issues does not negate the benefit you have the rest of the time: It can swerve in microseconds, you cannot. How many times will your nail removal skills save you or your kids live compared to software that knows that rolling the car to the left have a 87.34 better chance of occupants survival that the head-on collision with the truck that just swerved in 0.4 seconds ago ?

Forget it, driver-less s cars will be the norm in the future. You won't be able to afford the insurance associated with a meat-driven car.