skysight-inc/HackerNews huggingface dataset:
What are the reasons behind such prohibitive cost? Rare expertise, advanced factories, amount of time required, lack of economy-of-scale, monopoly, something else?

If the cure is proven, the society will likely be able to mobilize much more resources, particularly to scale up operations.

Special expertise can be trained to other biologists (the underemployment problem would be mitigated as well). More biologists could be trained. Likewise for factories, materials, etc. Monopolies can be broken.

What factors cannot be scaled up with such an approach? (Honest question. I do not know anything about antibody production.)
The Current State of Machine Intelligence 3.0
Alexa offers steep, exclusive deals in Amazon's first 'voice shopping weekend'
I'm fortunate not to know anyone with HIV, but this news truly brightens my day.
> People don't speed around mountain passes on snowy nights.

I don't follow. Driving on a snowy mountain road is still incredibly dangerous though, even after I've adapted my behavior.
It's just preparations for the impending first contact.

Now we'll be a little less surprised when they mention they've been around all this time.

Perhaps Kurzweil wasn't that far off after all..
This relation is often true, but not always. For instance, if a driver can't see past an obstruction and needs to pull into a crosswalk to look for oncoming traffic, he or she may neglect to look for a crossing pedestrian because of a prioritization of risk.

Progressive traffic engineering is required to balance these competing interests and safety needs on a case-by-case basis.
I'm working on likely the last product we'll ever make with z80 based assembly, so hopefully I'll be trying some alternatives in the next year or so. Thanks for the comparison.
Attn: Jeff Bezos
That book was my first introduction into stoicism. Really enjoyed it.

Highly recommend 'Meditations' next
Sounds very similar to urbit or sandstorm. The key difference being the single filesystem and single feed which are not explicit features of either of the aforementioned products but could be created on them or might be planned.
To be fair, wouldn't you then need to compare to AWS spot instance pricing?
The original was about how much cost is involved in something and what the break even point is. toomuchtodo asked a financially specific question. The reply to that question was vague and added that part of this cost was done in "free time".

My reply was perfectly suited for that response. It wasn't binary, it was begging the OP who said he/she works in his free time to stop calling it free time and answer the original question.
I'm assuming you haven't had much chance to compare, so I'll give you my impression (having driven rural roads in CA, NV, NM,UT,CO, AZ, KS, MO, IL,TN,PA, and every East coast state except FL in the past six months.) RI, CT, and MA are very uncomfortable because it's common to have narrow roads with rocks and trees no more than 18 inches off the roadway. In VA, for a contrast, trees grow everywhere, but along rural highways there is only relatively short grass for the first 15 or so feet off each side. And everyone who drives VA enough hates the state for its police (which I've heard frequently from people living in every state from new York to south Carolina.) There are also places in VA where that dynamic doesn't exist (west of the Appalachian trail) because, like you said, the winding roads, rather than police, do the job of slowing cars down.

And admittedly AZ is easy. Passing in the oncoming lane while going 90 is a pretty comfortable thing there.
It's a MYTH! That you can make a million dollars in no time at all by starting your own blog.

And I’m going to teach you find another way to make serious money, even if you haven't even started.

http://payhip.com/b/RZzw/af582f6d5b11daa
Amherst, MA.

https://www.amherstma.gov/DocumentCenter/View/24390

The Fire Apparatus Manufacturers Assn. thinks 26 states limit their equipment to 102" and another 17 are "exempt."
How these three Princeton students solved Facebook's problem of fake news
Having worked at many similar facilities and plenty in the telecom space, this seems like a lot of speculation. Nondescript buildings owned by telecoms are literally all over the place and the telecom requirements in that area - while a fraction of what they used to be - are still quite large. It would be surprising if a large CO was not present in that area.
People bought big SUVs to feel safer, but it's an illusion. 10 foot lanes would do much to contain this trend. They would also stop texting and pay attention.
LastPass can for people, and automation can for machines. And then you are the one point of control of your destiny, not the SSO namespace owner.
Lem's His Master's Voice is also in the same genre, but the section A New Cosmology from A Perfect Vacuum is much more specifically about this topic.
I'm from Minnesota and have put in 100,000+ miles of driving there, much of it in the winter. I'm not sure how I feel about removing trees and other side-of-the-road obstacles, but just wanted to point out that it's possible in very bad conditions to drift off the road, spin out on the highway, rear-end the car ahead, etc. even if you're being extremely cautious. I hit black ice at 30 mph on the highway and my car rotated a full 540 degrees, but fortunately didn't end up in a ditch. Sometimes conditions and visibility can be so bad in Minnesota, that I don't think any outsider can understand how difficult it is just to stay on the road. I've taken drives where you see cars in the ditch every quarter mile. I rear-ended a guy once, but he wasn't even angry because he saw my car slide slowly toward him from at least 50 feet away.
Gotta love that Obama-"we". No douchebag you aren't a traffic engineer you are not designing shit
I only watched the movie which made me lose interest in the book. May have to check again.
My apologies, I misunderstood some of the grumbling I had heard from some friends running a Sandstorm installation.

I just checked back with them, and they confirmed that I'm entirely mistaken.
snowcrash
Why not get him a tiny cheap media center PC or chromebook or such? You could probably even do this with a Raspberry Pi. Hook it up to a nice set of PC speakers. Set up remote access to it for yourself.

Then you can either download a selection of music to it or set it up to play from a streaming service just as you would on your own PC. If your dad wants to turn it on or off (or the caretakers need to), he can use the volume/power knob on the speakers.

Or if he likes a popular genre of music (classical? Classic rock?), maybe just get him an FM radio?
Amusingly, as someone who has first-party cookies disabled by default, those annoying "we use cookies" notifications appear every time instead of just the first.

Way to go EU..
IANAP, just someone with a lay understanding that's been following a lot of these topics for a while now.

As I understand it McCulloch's requirement that wavelengths fit within the cosmic horizon is an assumption, not a proven logical implication.

Additionally I think a lot of physicists are dismissive because they expect someone who desires to upend mainline theory to at least demonstrate fluency with the mathematics of mainline theory. McCulloch falls short of this.

All that said, I think he's genuine in his pursuit and I've really enjoyed reading his blog over the years.
Meanwhile, all the other nations on Earth are tuning into the unsecured calls to and from a different Manhattan tower:

http://www.trumptowerny.com
I had an other smart acquaintance who believed replacing airbags with spikes would make people safer.

Ridiculous.

That's like saying that decreasing did production will make people use food smarter and starve less. It'll improve the efficiency of food usage, but fewer people won't starve.

Steering wheel spikes will improve driver habits, but people won't be safer overall.
In a related question, there is some evidence that bike helmets may lead to greater risk taking and thus increase the likelihood of a crash (though bike helmets pretty definitively reduce the risk of head injury should a rider be in a crash).

http://bigthink.com/neurobonkers/the-bike-helmet-paradox

Your "inescapable conclusion" would probably depend on whether the driver actually perceived the increase in risk. The spike and bubble might, but removing airbags might not.
When I travel with my laptop, I often don't have access to power.

Most trips in a car are less than 100 miles. Yet nobody wants to purchase a low range EV. Extended battery life is useful on the occasions you need it.
In a lot of older areas the roads were built just big enough for farm to market purposes[1] either officially (as in Texas) or unofficially. This resulted in narrow, twisty & curvy roads that encourage people to drive slower and safer.

The safer a road is perceived to be through visual cues (wider, straighter, less hilly, etc) the faster drivers will go. Hence why in Seattle and other cities dangerous (read wide, "safe" feeling) roads are being put on a diet, and going from 4 lanes to 2 lanes with a center turn lane and bike lanes (sadly usually unprotected). The same thing is being done in Denmark, where they actually add curves & planters to the roads to force cars to curve and feel unsafe, which ultimately results in safer streets for everyone involved.

Another strategy that I've heard has better results is eliminating sidewalks and getting rid of jaywalking laws, so that traffic of all types are forced to intermingle at much lower speeds.

[1] - https://en.wikipedia.org/wiki/Farm-to-market_road
Let's call it QR-Video, theoretically the world's most useless protocol as you only need a link and one still frame will suffice. However there is something nice about QR codes and it would be cool to stream information in this big visual way between phones, e.g. a business card sized piece of information.

The problem I have with QR codes is that they do not just work. You need to download a QR code reading app, this functionality should be hard coded at a deeper level, a notification appearing for QR codes no matter what you are doing with the device.

Many of the apps for QR codes do things like sneaking in affiliate marketing codes, this can malform a URL and do some redirection along the way for monetization purposes unknown.

Maybe QR codes deserve the video mode to become a protocol like this of sorts to be there for innovators with uses to be invented. QR codes are here to stay, they are too useful. They need acknowledgement as a thing and for phones to do a lot better out the box at hzving QR code readers baked into the OS.
The Intel chipset being used supports the following kinds of RAM: DDR3 RAM, Low Power DDR3 RAM (LPDDR), and DDR4 RAM. However, LPDDR3 only goes up to 1600 megahertz in speed, but Apple uses 1866Mhz RAM. How is this possible? That is because there yet another RAM standard, known as LPDDR3E (E for enhanced) RAM, that does go up to 1866Mhz.

LPDDR4 is not supported by Intel’s CPU, and the DDR4L (another low voltage RAM type) standard is not finished yet. So desktop class memory (plainly spoken DDR4) would be the only option if they wanted to go past 16GB.

I don't follow the argument here. Why not just put another 16GB of LPDDR3E on the board?
I agree. There is a point where thinness and long battery life have diminishing returns.
Without self-determination, you have no future. The historic record is full of examples of this.

Even if you survive, it does not matter - because you become an invalid in your own home.
This exactly. As a developer applications like docker and vagrant are part of my normal activities. The 16GB limit just does not work in this model. FWIW I was waiting on a laptop upgrade, and after seeing the new lineup from Apple I ordered a Linux laptop with 32GB of memory.
Yes they vet the information, but if the information is true, then they publish it, regardless of who the source was.

Vetting the information does not necessarily mean vetting the source.
My issue with the article is that it doesn't really scope the problem. A six lane boulevard or highway in a city is a different animal than a typical street, and the examples seem to be those large through streets.

I live in a state where the the state only maintains state designated roads outside of cities. So maybe I'm weird. But generally, I think it's safe to say that boulevards, regardless of lane width tend to be unfriendly to non-automotive traffic. Side streets with marked lanes are rarely wide.

So other than stating that engineers are Uber conservative, the problem really isn't defined.
Truly forgotten. I have read a number of works by Smith but never came across this one. Would be adding this to me reading-list.

On a side note, this sounds a lot like The Bhagvad Gita[1]. Is there a relationship between these two works, or is it just great minds thinking alike?

[1] https://en.wikipedia.org/wiki/Bhagavad_Gita#Karma_yoga

[EDIT]: Grammer
Great writeup and detail. However:

> Even if it weighed 10 kilos and cost $10k I would still buy it.

> (To show you exactly what I mean in terms of personal needs, I recently rendered a music video in HD using a neural net called Style app. Due to the 16GB RAM limitation it took several days and wrote 20.44 Terabytes to my drive in swap space (yes, over 20,000 gigabytes). This would have been an order of magnitude faster on a system with 32GB of RAM).

If your rendering video and can afford a $10k computer, then you should be using a Mac Pro. You can get a 2.7GHz 12-core with 30MB of L3 cache and 64GB of memory for around 8.5k.
A year or two ago the TeXmacs package worked pretty well.

There is also an actual Octave kernel for Jupyter, similar to the Julia one: https://github.com/Calysto/octave_kernel
Oh yeah there are a few Bayesian methods which work great, Bayes-UCB is another. Personally though I think KL-UCB or just plain old UCB would be the ones I'd choose. Like I said earlier, I think these techniques are like programming languages: choose the one you know well enough to get the job done with it.
I am very excited about this! I recently got re-introduced to the Polymer project. What they are doing is definitely the future of front end dev.
And furthermore, Intel CPUs can already power down caches to lower power consumption; there are ways to power down unused RAM too: https://lwn.net/Articles/446493/
tldr: https://youtu.be/VEfIYZox1GM?t=8s
"Anyone intending to be a serious user of AWS will use reservations."

Not in my experience... It's impossible to predict the kind of usage you're going to need over the next 1-3 years, especially when you're first getting started with AWS. If you underestimate, you waste money. If you overestimate, you waste even more money. Google's concept of "sustained use" discounts is _much_ more appealing to me.
I think it's a catch-22, if the laptop had 32GB ram but 5hr battery life, folks would complain about it because, for example, it wouldn't last on a flight from East/West coast flight or across the pond.

Damned if you do, damned if you don't.

This whole MbP experience feels rushed; Like a new tech release. You see the possibilities but it just falls short...
These trees have been too big and too numerous the last 50 years or so. Some sort of cull was to be expected. Lightning has traditionally been nature's way of cutting back undergrowth and surplus trees but that's no longer considered an option.
First I don't think that the people who want (need) more than 16 gb ram would be okay with 50% less battery, at least not the majority, but, if apple would do that, how should they put that device on the market?

As a MacBook Pro+-, the one with 32 gb ram but only 50% battery life? Or just a note on the site that this device only gets up to 5 hrs of battery life? In my eyes, the number of people confused and/or pissed of by that would be far higher, than of those who need 32 gb and would be okay with 50% less battery life.
All 10 volumes free of HathiTrust's walled garden (i.e., available as full PDF downloads without having to be a member of a "partner institution"):

https://archive.org/details/worldsbestessays01brew
https://archive.org/details/worldsbestessays02brew
https://archive.org/details/worldsbestessays03brew
https://archive.org/details/worldsbestessays04brew
https://archive.org/details/worldsbestessays05brew
https://archive.org/details/worldsbestessays06brew
https://archive.org/details/worldsbestessays07brew
https://archive.org/details/worldsbestessays08brew
https://archive.org/details/worldsbestessays09brew
https://archive.org/details/worldsbestessays10brew
OK: http://www.politifact.com/punditfact/statements/2016/nov/18/...

Did I do it wrong?
Fair enough, with the right distinction between universe and observable universe they are certainly compatible.

Any discussion of the characteristics of the universe outside the observable universe runs into some interesting epistemic problems around what constitutes evidence. Maybe it's turtles all the way down, or teapots. Good luck trying to estimate the prior probability of an infinite number of possibilities with an ape brain that evolved to hunt and gather on the Savannah.

I find a lot of pop science at the fringes of our knowledge (QM and astrophysics) relies a lot on infinities to justify cool stoner ideas that are unfalsifiable and chosen entirely based on human biases of what would be "awesome". I do have a very strong bias against these because of this obvious element of wishful thinking. The infinite-alternate-realities-of-the-gaps argument is just the god-of-the-gaps argument for the "I fucking love science" crowd.
General Grievous. But actually Count Dooku. But actually senator Palpatine. Who has recently been elected Supreme Chancellor. But actually Darth Sidious.
Have you looked into libpostal?

https://github.com/openvenues/libpostal
I would personally add a toaster oven to that. For relatively cheap you get a full-featured oven that can toast as well, often with convection these days.
Good luck reading what he wrote. His ideas were sold better by others. His writing is almost impenetrable. And ditto to everything parent said. Been studying him on and off for 40 years and in many ways he was his own worst enemy.
In other discussions about this, the point is made that there are some very nasty things buried in those landfills. (I'm certainly no authority) Hazerdous waste, bio-waste, etc.

The mining technology would have to include something to mitigate that. Not just as immediate safety, but what do you do with it once you've dug it up? Or through it?
https://en.wikipedia.org/wiki/Speed_limits_in_the_United_Sta... suggests that 50mph would be unsually high for a residential street.

As for the rear view mirror hinges: what on earth did you think they were there for, if not for saving your mirrors when they get whacked?!

(A somewhat common optional extra for cars is folding rear view mirrors. Some probably fold away automatically, I'm sure; mine make you press a button first. But my car is old. I bet the automatic folding is more common these days; modern wing mirrors often have integrated indicators, and that's going to increase the cost of replacement.

(Sole purpose of the folding feature? Saving your car's wing mirrors from getting hit when you park on a narrow street.)
It sounds like the big component missing out of this plan is the sorting component; we don't yet have robots capable of looking at a big pile of arbitrary junk and picking out the useful bits, let alone ones capable of intelligently tearing down an iPhone. Once robotics does have that sort of capacity though, I'd bet this sort of recycling scheme would be more likely than other commenters suggest- replacing skilled human labor with robotics has a track record of making unexpected things economically viable.
I understand the need for life to go on in places with hostile weather, and also that unexpected situations come up.

But at some point, a reasonable standard must be set, and if you can't drive safely you shouldn't be driving. Clearing obstructions on the side of the road won't really help if you're spinning out of control on a busy highway.
I just watched the talks of Google IO and Polymer Summit, Polymer has a lot of big name users (Coca Cola, net-a-porte have no clue what this is, EA etc)
I have the new MbP w/ 8GB RAM and ram 3 VMs (2 MS build for IE testing and 1 hetoku build-pack) + IDE consuming close to 1GB of ram and compared it to a mid-2014 MbP with 16GB ram with similar performance. Yes the 8GB was a touch slower but I assume with 16GB, it will outperform similar or upgraded systems.
Can you recommend any introductory texts regarding protein complex binding dynamics?
Tim Urban Is an Expert on Not Being an Expert
Is there a kindle friendly version?
That is a pretty far off base conclusion, the goal is to make roads feel unsafe for drivers so they go slower, and reduce or eliminate commute distance, that is how roads are made safer.

For example, a common strategy is to narrow a road from 4 lanes to 2 with a center median, being either a turn lane, planter with half height jersey barrier (directs cars wheels back onto the roadway), or barrels filled with water (which absorbs impacts and makes roads much safer). Tactics like these make roads feel more claustrophobic and thus "dangerous", but the road is ultimately much safer in the event of an accident, and accidents are less likely due to drivers being more alert because of the narrow roadway.

TL;DR: Wide roads lull you into a false sense of safety, narrow them!
Actually, because you've got to pay in advance a certain amount to get the reserved price, we calculated at my last job that buying on-demand instances was actually cheaper than paying the reserved instance pricing listed, because of the rate at which AWS drops the price regularly. Meaning, if you compare the reserved price with the amount you would pay for on-demand instances and subtract the amount you save when Amazon drops the price (which they do pretty regularly, and have in the past), the on-demand price actually ends up being cheaper in the long run.
Forget the drones. Buy up a bunch of land next to a landfill. Buy an old excavator for $20k. Buy an industrial shredder for $30k. Buy large steel wheel. Spin wheel to separate particles by density. Recycle plastics. Melt metals. Sell. Be unprofitable. Lose money. Have fun.
But electron and other particles are actually demonstrating interference patterns, so it is not just interpretation. They are particles and waves. Waves are propagating.

Walking droplets demonstration of quantum-like behavior is also done with transverse waves (waves, which are perpendicular to plane of motion of droplet). OK, they are no expanding and contracting, they are rising and falling, thank you for correction.
Actually Jar Jar
What argument? You asked me what the likelihood would need to be.

You mean the seat belt argument? The cost to society of reducing co2 emissions exceeds the cost of a seatbelt by a factor of several billion.. even trillion.

A nearby star could explode and kill us all. Should we figure out how likely that is before spending trillions to fix it?

Did you mean answer your question about what the odds would need to be? I would first need to see the rhetoric tuned down a bit, some listening to minority researchers first. Considering the effort spent in silencing them, the whole thing stinks to high hell.

Who else but phds have credibility in climate science, other than perhaps phds in another hard science? Some citizen advocate? Please. If we had this nonsense in medical science eggs would be illegal by now.
I suspect the iPhone approach of new release then a higher performance "S" release of the same device a year later has taken hold in the MacBook division.
This is a really important thing - this dead tree thing - while caused by drought, is largely a function of poor forest management (read, no fires allowed, ever) for a century or so.