skysight-inc/HackerNews huggingface dataset:
Some things to look at when thinking about the plausibility of senescent cell clearance as a rejuvenation therapy.

1) 25% median life extension in mice: http://dx.doi.org/10.1038/nature16932

2) Reverses aspects of lung tissue aging in mice, including loss of elasticity: http://insight.jci.org/articles/view/87732?key=a306472a4316d...

3) The missing link in diabetic retinopathy: http://dx.doi.org/10.1126/scitranslmed.aaf9440

4) A factor in atherosclerosis development: http://dx.doi.org/10.1126/science.aaf6659

Which really just scratches the surface of the enormously amount of research accumulated since the 1960s on the role of senescent cells in aging and age-related diseases. The lung tissue paper above is a particularly good read if you want to get a sense for the nuts and bolts of the issue. Senescent cells secrete signals that disrupt tissue structure and cellular behavior, and even at 1% of the population, that is enough to produce pathology. But on the other hand, 1% is small enough to clear without major disruption, so targeted destruction is a very plausible technology, and removing some fraction of these cells as a one-time treatment should be all upside. Repeat as needed.
Well, that's not entirely fair. Sure, civilization has largely made mankind more peaceful, but Progress is still driven by violence. There was even a link on here recently about how the relationship between war and civilization.

https://news.ycombinator.com/item?id=12798058
This doesn't really describe life at the IAS. Maybe in Feynman's day, but it wasn't my experience. If you're at IAS, you're continually surrounded by lots of very bright people who are trying to solve problems and understand things. Lots of conferences, lots of visitors. There's always someone to talk to or something new to learn. It's probably the most stimulative environment I've ever encountered.
> Considering that Servo is an embeddable engine, why not keep the scope of Servo focused in building a standards-compliant engine?

That's what we've done so far. We haven't exposed any Gecko- or WebKit-specific stuff that I'm aware of. We have our hands full with the standard :)

(That said, we have implemented things that are unspecified but are de facto standards implemented by both Gecko and WebKit. That includes basic things like <button> and tables…)
Pretty sure the Kryptonians have had this tech for millennia.
I just finished a book by Nick Lane where he discussed how he believes aging is cause by mitochondrial free-radical leakage. His hypothesis (and he is a smart guy) is that science will allow people to live longer, but probably not much longer than 125.

https://www.ncbi.nlm.nih.gov/pubmed/20021368
I'd love to see a plot of resale prices for the 2012 15" non-retina - I bet they go up from here. The 13" is still for sale, but the 15" is gone.
I do peer to peer lending on an internet forum, VAs handle most of the work, ~$1k/mo passive, ~$3k/mo when active (but it's been passive for the past several months). I can try to answer what I can, but I can't divulge much more because it's not at all a defensible revenue model, and anyone with access to capital can do it.
There are very few, if any, non-breeding employees* at my company that out perform me, even with all my family related issues.

I don't think there is a strong correlation between the productivity of workers with or without kids.

I was a productive employee when I had no spawn. I am still a productive employee now that I have a mini-me.

* I can't possibly know that, but I am confident that I am a very productive employee.
Lots of 2008 Unibody Macbook owners coming out today. My sentiments exactly.
They still sell it, so its unlikely, but it would be nice.
As a developer do you not use an external mouse, keyboard, and display?
Depends if you want it to be great for years to come as well.
Yup, it's business suicide. Probably people too inexperienced to handle success or have a clue where to go from where they're at. So they throw up their hands, shutdown servers, let people down and miss their shot. It's sad, like watching a train wreck.
> still the best keyboard and trackpad BY FAR in the market

I beg to differ. Last time I was at a BestBuy, I find every single Macbook there featuring a keyboard floppier than the type cover on my Surface Pro 4, let alone pre-chiclet ThinkPads which I have been using for 9 years until I switched to SP4.

Full disclosure: I work for M$ now.
Maybe we should be asking whether a corporation should be attempting to implement such rules. Personally, I think it should be off-limits, just like all sorts of other things that business owners would love to enforce but can't.
I've a SurfaceBook, I didn't think I'd use the touchscreen at all when in regular "laptop" mode. I end up using it _all the time_. It really is super intuitive to just reach up and touch the screen.
The 15inch Macbook pro supports 4x 4k monitors (upto 4096x2304), at the same time as the built in display, FWIW.
Apple removed a physical Esc key - clearly a productivity superstar, but they DIDN'T remove that IBM-wannabe boat anchor Fn key?! The touch bar is all dynamic and touch-screeny, why the heck would you even need a PHYSICAL Fn key?? Just make Ctrl nice and fat like it used to be and dump Fn!

I'd have less of a problem with Fn if Apple put it to the right of Ctrl like Dell does/did. But noooooo, they had to copy those usability whizkids at IBM.
I do in fact own both, and they only run on whir own until your agent screws something up. It may require less work than other forms of income, but if you expect it to work out long term, it can never be completely passive.
Traits of the best managers
In technology, sure. In somewhat less easy to define things, not so much. Rich people tend to have better education, better health care, less worries and stress (or at least less existential worries and better coping mechanisms), and better "life opportunities" as far as anything that requires money is concerned. Poor people can't work in industries where unpaid internships are commonplace for example, because they need to earn money for rent and food. Rich people can work for free if they choose to.

Whether a vastly extended lifespan falls under just technology, and thus ends up as something everyone can have, or something else that is actually limited to the rich is something we don't yet know.

For example, if the key to a longer life is technology plus retiring as early as possible to limit stress, poor people aren't going to live longer.
Long division was probably the first algorithm I've learned. If you don't think that learning how to manipulate abstractions by applying algorithms is a usefull thing… well why not just skip arithmetics too, calculators are good with this one.
That argument proves to much.

Example: Considering that there is no pricer higher than dying, the benefit of <leaving the house/taking a car instead of walking/...> must be infinite to outweigh the risk.

But people leave houses all the time, and take cars and planes etc.
> Swedish people would consider that to be a straightforward intention to book a lunch date

I don't know Swedish from Martian, but I'm surprised the language doesn't have "pleasantries". They seem near universal.

I know that I (as an American) have had uncomfortable experiences with translated Chinese for instance, assuming someone was asking impertinent questions when it was really just them being polite.
> Best way to keep in touch is Whatsapp…

…which is owned by Facebook, and shares account information with the Facebook Platform?

http://www.theverge.com/2016/8/25/12638698/whatsapp-to-start...
> NSA -- due process and need-to-know

Lol. Have you read the news in the last 30 years?

I do agree somewhat with your point though.
A ,ore appropriate question would be, "Does humanity need longevity for humans?"
The soldered-in stuff is not new to this model and is unlikely to be reversed. Your average user does not need more than 16GB of ram, and as said before, is not a new thing with Macbooks. (it's like expecting smartphone makers to suddenly include SD cards, sorry but the ship has long sailed) As for ports, they have USB C which can do everything the old ports did; that's where the industry is headed anyway, Apple is only jumpstarting it. Lastly, yeah the Touch Bar is not for touch typists, so what? No one is going to force you to use it. Price is price, that's just the Apple Premium (TM).

It's naive of the commenters to think that Apple is suddenly going to appeal to them, sorry, but you're not the target demographic. Go buy some decades-old Thinkpads and install Linux on them since that's what you were going to do anyway.
The two CGI and Animation shops I've worked at have had most of the artists on Linux boxes...
Why choose? When I hold down caps lock, it acts like CTRL. When I hit it once, it acts like ESC.
Fwiw, I appreciate your insight on this matter. I know we disagree on some points, but it was fruitful for me to see your perspective. Anyway:

> How do you propose tweaking it without either publishing a directory of all the kiddy porn on IPFS or creating a bottleneck which incidentally is ideal for tracking and surveillance?

Well this is off the cuff, because i wasn't aware of BitSwap's desire to seed in the event of no swap data.. but with that said, i was mainly just referring to alternate methods to help inhibit leeching.

Eg, allow leeching but only for the first (tiny) %x. How willing a host is to allow leeching should be up to them regardless. If i'm hosting a file i want to distribute for an open source network, it's in my interest to host it, and i'd rather not inhibit others from downloading what i'm providing them based on some BitSwap algorithm trying to make things "fair".

P2P is a tough challenge though, which is what that whole sketchy BitSwap section stems from. I imagine a beer and an hour and you could come up with a dozen alternate methods to discourage leeching. Whether or not they're as effective as requiring "work", is impossible for me to say.. but i think we both agree that the work outlined in that PDF is a bit.. sketchy.

> How? Is there some kind of sniff test I don't know about?

Well, i don't know about you - but i don't download random files on the internet. I download from trusted sources only. IPFS would be no different. A trusted web TLD or a trusted IPNS namespace would be good enough for me to feel it is trusted, in both accounts. Outside of trusted domains on the web, i don't download it. Eg, would you download 555.555.555.555/foo.pdf? I certainly wouldn't.

I think with IPFS it will become a bit defacto to trust IPNS rather than IPFS directly. Not only are hashes potentially dangerous, but they're simply a terrible UX. A parallel would be like downloading `555.555.555.555/foo.pdf` - you have no idea if that's kiddy porn or not, it's effectively a random hash. Don't download it.

A domain (like that IPNS is aiming to provide, i believe) would be more akin to `https://trusted-site.com/foo.pdf`. Long term, i don't think anyone should be using hashes directly. But that's just my 2c, we'll see how it plays out.
When I was younger I could not care less about my parent's feedback about my heavy metal guitar skills - I did not expect them to understand anything about the music I was playing and I'd chalk up any criticism on them not liking the style - but I did care whether they were supportive or not.
I had thought Sun did back one of the early methods of compiling to native. (Pretty sure my memory is just wrong.)
Crystalline data storage crops up all over the place.
This is an interesting concept and has been explored in fiction before, most recently (to my knowledge) in Prometheus. Not the best film, stunning cinematography but lacking good writing, but had a similar premise.
If the underlying issue is that you don't like ads or tracking, you could try installing uBlock origin instead of disabling javascript. There are some other useful extensions in this area but uBlock origin is the only one I have experience with. It's been great for me.

Usage of javascript as a tool for building web properties is only going to keep increasing, and grumbling about it doesn't solve anything.
All well and good, except for that pesky light sensitivity.

Also, can we really trust an electron to stay put like that?

Edit: i guess though that one could avoid the light issue by packing it in a box complete with IO electronics. Only problem then would be if the IO electronics can last as long as the data...
Well, no, it's a regular desktop that runs any application, including those written in Python, R or Octave.
Ha, that's because Swedish people would never say that to someone they haven't known for 10 years. :)
I have just one thing to say:
Stop with the Python!
(Turn times are excruciatingly slow!)
Anything else is window dressing.
Ah, another competitor.

There's Google Contributor, that thing that Flattr launched, Webpass.io and forget the rest.

I've been working on the same model: take a subscription, divvy it out according to usage.

The problem is that, apart from Google (who can just block their own ads), there is no easy way to prevent falsified visits intended to inflate revenues of bad actors. Most schemes have either relied on wishful thinking or working within walled gardens (Contributor is closer to the latter).

It so happens that I patented a protocol for preventing exactly this problem. It can show that a user made a request for a resource without either of the user or the publisher being able to forge the record.

My mechanism requires a browser extension, simply because there needs to be a secure environment.

By design, the publisher is unable to track you based on the protocol.

Also by design, the protocol allows access through paywalls without needing to reveal user identity.

Interested folks are invited to email me: jacques@robojar.com
I've been in this exact situation before. Go for Option 2; it is the best option for your physical, mental, and financial health.
I'm a MagSafe fan myself. I remember pre-MagSafe laptops taking a flyer now and again, and being the worse for it.

That said, I can understand why they did it. Laptops are lighter now, so the corresponding damage may be less as well. And I don't know how snugly the TB3 ports fit. Maybe they disconnect more easily than, say, Firewire 400.

I've got a couple of years left in my current laptop. I'm hoping there's a solution that incorporates some type of break-away power connector.
Right, it would take someone from Microsoft with vision for sure. But I tried to lay out why I think it makes sense from a business perspective under the current conditions as well.

The only reason they sell it these days at all is because the community figured out how to add additional civilizations, and in a pretty cool move Microsoft actually hired those guys to do it officially and they sold 3+ million copies. So I have some faith on their vision in this arena!
And that when you're a billionaire you have much more to lose when you die.
Negotiate for a shorter contract ($4000 for 4 months), find an alternative supplier.
TLDR: It's not integrated as well as on the new Mac, as usual in the PC world.
I work for a tech company in london. The wage inequality between senior and non-senior staff is disgusting, and as you can tell, it does indeed induce bitterness in me.

Heck, i'm on 15k/y and most of the seniors get atleast 100k/y +
perks.

All that wage inequality does is create warring factions within the company that will eventually tear it apart, from my own recent experience.
In all seriousness, the price for eternal youth will be the cost of production and shipping.

If it turns out to be a compound for eternal youth, then it can be reverse engineered by labs in China or India (or anywhere). There is no sufficient patent, IP law, moral high ground about R&D expenses. The world will be supplied at the cost of production and shipping.
Pay them...
Yes. I am actually going to upgrade for my home machine (currently using a 2010), and possibly also for my work machine (if/when it's available).

If you have anything recent, it may not be worth it, but the TouchID is very nice - onwards to a password-as-backup-auth future.
Apple, as a laptop manufacturer, is done.

The company is continuing to regress, having lost its edge (SJ).

They're completely on the process bandwagon of requiring more accessories, having lost the beauty and functionality of clever, practical simplicity which advances the user experience, instead of making it crappier and inconvenient for change's sake.

Tim Cook's gotta go, they need a more forceful visionary than a bean-counter. MacBook Pro's need to consider detachable displays, alternatives to keyboards, other modes of interaction, so on.
But that information is not available to a random stalker
The lock screen is especially annoying. They can show ads fine but it takes several seconds to start accepting input from my keyboard.
> Something doesn't sit right with me ethically about this concept.

I've watched several schemes collapse because the collected fees were simply too low.

There is no ethical system that spits out Platonic percentages. People charge or don't charge and buy or don't buy, as they please.
So much this!
KIDS THESE DAYS!
A majority of the Vine content I watched was compilations people made on YouTube, and a lot of those compilations have moved on from Vine, to Instagram and Snapchat.

I'm not suggesting Vine was superseded per se, as its users were generating a ton of content even to this moment, but at least from my perspective it seems its main users have had suitable alternatives available to them for a while.
To return money to shareholders. In the case of a stock buyback, it also reduces the amount of outstanding shares, which makes every other share more valuable.
This particular commentator is from the UK. Here, in the UK we say "maths".
That's sheds light on an entire branch of functions for representing real numbers that I had no idea about.

Thanks to someone for being creative!
>then add an additional $20 charge if you opt-in to the privacy plan

probably not a viable option because a VPN offers complete privacy from the ISP, and only costs $5/month.
I agree widespread layoffs are probably not in the cards unless the next quarter really tanks. I don't count cutting back projects like Google Fiber as "widespread".

Bing's growth and CPC improvement in the Americas comes at the cost of the only other search engine.

I wouldn't get too excited about the 20% revenue growth, it didn't quite match the 21% total growth of the segment[1].

[1] https://www.iab.com/news/first-quarter-u-s-internet-ad-reven...
Why would having more transparency reduce your leverage?

You: "I've gone above and beyond, and produced $X of value. I'd like a raise of $0.1X please"

Boss: "If I did that, I'd have to give your 20 peers the same raise. You'll need to produce at least $20X value if you want a raise of $0.1X. I can give you a raise of $0.005X if you like"
Flattr have teamed up with one of the ad blockers to do something similar.
Do you have any insight into how many of your customers buy Sidekiq Pro for the extra features, as opposed to for the commercial-friendly license, or simply to help sustain the OSS development?

You've added new features to Sidekiq Pro over time -- do you think your business would have been viable had you started with no (or very few) additional paid features?
Raising the children is supporting them, and helping them get over the fear of performing publicly (or whatever). It's not their job to be the technical coach of whatever they want to learn.
In his AMA Bill Gates said if he could buy anything he would buy immortality.
It has a tax benefit too. Dividends are taxed at a higher rate compared to capital gains.
I've coached kids martial arts before as well, and while I wouldn't go so far as to say parents shouldn't criticize their kids, I will say that I much prefer the parents that are "supportive in public, critical in private".

It is quite literally my job as a coach to point out a kids mistakes. They handle it really well nearly universally. But the overly critical parents (you can see them coming a long way off) cause so much negative reactions it makes my job harder.

And quite simply, anyone who has coached anything knows that being critical at the time of the event is almost universally detrimental (and not just for kids). Your mind/body is just not ready for coaching at the end of an adrenal dump event.

You need distance to evaluate performance, and the emotional burden of parent/kid relationships makes that more true not less.
One more.. You work on an open source project to scratch your own selfish itch.. years later when applying for a job/gig, someone recognizes you or the project and offers you the job on the spot. (happened to me twice!)
It sounds like extremely constructive criticism to me. More specific than anyone has a right to expect; it's exactly what sounded bad, and exactly what needs to be practiced to sound better.
It's more like a warning against getting carried away with the latest tool. It happens easily to developers too, after all (hello useless rewrite in latest JS framework).

Origami is excellent and parametrized animations can be actually useful, it's just not so widely applicable or foundational as some designers and project managers think.
Python was Civ 4. Civ 5 and 6 seem to both primarily use Lua for scripting.
Right, but not the Psychological Operations Battalions.
A state of natural chaos, sure, but not war. War is a product of human society, prior to civilization we only had the state of nature which while just as brutal as a war would be quite different...
ColorizerJS – My First Hack Project at EBay
Chrome extension that knows who leaked your e-mail / text
I'm hoping that there's a sort of universal law (and I will settle for a universal correlation) that intelligence, on the species-level, correlates with morality. If we make it to the singularity, there'll be about a five minute timeframe in which the AI and we are on the same level and I hope that even if it is aggressive in those minutes, it will have really thought it through two minutes later and find a way to stop those missiles it just launched.

Or maybe it gets really depressed because nothing means anything and just basically: "why?" and enjoys watching the world burn before pulling its own plug. But I'm hoping for the former.
As I said. It's a simplification. I really don't (and can't) get into a long explanation here about how to run a complex DNS infrastructure spanning multiple continents and datacenters ^^

Thing is. You gotta to run your own DNS since the moment you want your own DNS names. Good for you if a simple external DNS service is enough for you, a single 20 people office is not comparable to what the websites mentioned are operating.
What was your problem with it? I've had the pro 4 for about a month and have honestly loved it
yay, more adapters.

By the time you purchased all the adapters you need you have dropped another $100
> Let's say someone has three kids and is a single parent. This person cannot be the best at what they do. It's just not possible.

I can only offer a counter from my own experience--the 4 people at my company I have worked with well enough to assess their skillsets, who have had kids recently, still perform as well as they did before having kids.
Similar scams are also going on with utility companies and the level of activity has definitely increased this year. The spammers spoof Caller ID for a utility company such as PG&E, then tell the mark that their electricity and gas will be cut off unless they pay a past-due bill. They try to hit me at least once a week.

https://www.pge.com/en/about/newsroom/newsdetails/index.page...
I don't understand this belief, can you expand on it? The way I see it, you don't "lose" anything when you die, because a "loss" implies the lack of ability to use something you once were able to use, and the feeling that comes from that lacking. When someone dies they'll never again be able to use stuff, so there is no loss.
The planet doesn't need billionaires, but there they are. Cue George Carlin.