skysight-inc/HackerNews huggingface dataset:
The Click Wheel wasn't until the 4G though in 2004. That was my first and that's arguably when the iPod really broke out.
>Why can't Twitter just be happy being Twitter, knowing its limits and making a stable profit?

The short answer? Because they don't make money.

I guess it's possible you could grow your company to a point where you say "Okay, we've filled our niche. Growing more doesn't make sense, so we'll just extract as much cash as we can."

The problem is you have to make money to do that. Twitter doesn't make money and never has. They can say "Well, we're still growing, and that costs money, but at some point we'll monetize that growth and make tons of money," but it's only credible as long as they're growing.
> ML is the one I'm most excited about at the moment.

I don't deny that ML is useful (I work in the field of statistical inference), but I am bothered by the characterization of "ML" as a great invention.

First off, "ML" is not really new per se; it has gone through iterations over a long time frame. Pattern recognition (via discriminant analysis, a method that is still popular in a variety of circles) was introduced in 1936. One could argue that there were statistical works addressing this at even earlier time frames - see e.g "The History of Statistics" by Stigler that focuses on linear regression, a method with at least 250 years of history. Popular methods like nearest neighbor date to at least the 1970's. Even the "revolutionary" deep learning paradigm had most of its key architectural ingredients mapped out by the 1980's or early 1990's - the main changes have been the scale at which one can operate these algorithms, tweaks of algorithms, etc due to improvements in hardware. This in turn has fed a bunch of further developments, the stage we are at right now.

Essentially, what has happened is that "ML" has appropriated a variety of disciplines and techniques under its umbrella, many of which have existed for a long time.

As for why concretely (i.e from an economic perspective) I lack the same level of enthusiasm as many others here, I have the following test: Amazon (or for that matter Google or your favorite search engine) has rarely been able to recommend me a nontrivial product (nontrivial in the sense of transaction magnitude) that I liked within the first few links. The best nontrivial products that I have acquired have always needed meticulous searching through a variety of diverse sources on the web (reddit, youtube, random blog posts/discussion forums including hn, etc), conversations with people, etc.
Same goes for movie recommendations, and miscellaneous other things.
This was true 7 years back, it is still true today for me.

This suggests either that these problems are genuinely hard (e.g at an NP-complete fundamental level), or that we still don't know how to come up with good recommendation systems, or that companies have failed to incorporate/package techniques into a good product, or that I am just an outlier with respect to recommendation engines.
Bombing civilians is never okay, though; it's not okay when the government does it, it's not okay when the rebels do it. It should be roundly condemned regardless of the perpetrator, and brushing it off as "defending territorial integrity" shows your _own_ bias, in my opinion. There are no "good guys" and there's a fucked messy situation there and I personally only have sympathy for the completely innocent people caught in the crossfire. Anyone doing the firing I have none for.
My wife studies domestic violence and notes that there is no code for strangulation. Talk about bike-shedding.
Even with your analysis, the numbers look pretty bad. I get it if you're being critical of the journalism. But, if you're trying to suggest that rich and poor have equal (or even relatively equal) opportunity, you'll have to present different evidence.
The workflow does not, and so far as I can tell, never has, support this. I've commented on it for years at G+.
If their are less than two USB ports on the new Macbook pro, I'll be going for the last years version.

Magic toolbar doesn't excite me - never used the similar function keys on PCs, even when I had them.
I remember this from Weeds
Right, the second sentence describes a conspiracy theory, and the end of the article dismisses this theory. The person you were replying to concurs with this dismissal, and presents additional evidence.
Anyone got a better source with more info on what they're talking about?
Isn't Telegram, which is base of Instagram name is original?
I think you're assuming that I meant not playing the game going forward. But if we hadn't been meddling in the Middle East for 40+ years, then perhaps there wouldn't be the amount of chaos we see now. Any time I hear the phrase "national interest" come out of the mouth of a politician, I roll my eyes. It's usually some thinly-veiled excuse to drop bombs on people.

And let's not delude ourselves: the giant social welfare states in Europe and the United States act as magnets for refugees and immigrants.

The level of cynicism in the world's leaders is breathtaking. How many leaders said anything along the lines of, "We will take as many refugees as our people are willing to feed, house, and clothe, since the people of this nation are the most generous, loving people on earth"? Not a single one. It's always got to be the job of the State when a politician comes up with an idea. And of course the people get to pay for it through coercive taxation no matter if it's a good idea or not ;-)
And since FB ads are useless, that's saying something
SMILES strings are not necessarily unique; each molecule can be encoded multiple ways as a SMILES string. As a sanity check, you could pass multiple representations of a molecule into the autoencoder to see if they generate the same continuous representation. Otherwise, you may end up essentially training to the peculiarities of whatever algorithm generated your SMILES strings.
This seems a lot like Facebook's graphql
I stand enlightened!
Sysop DARK KNiGHT BBS, not really sure on the years anymore, but I remember mowing a lot of lawns to pay for the damn phone lines.
Behind This Plant's Blue Leaves Lies a Weird Trick of Quantum Mechanics
I'm guessing that the underlying algos and tech are all roughly the same so the costs are probably also very similar.
I was a college freshman going from home dial up BBS's to a major university's internet speeds. Ripped a bunch of CD's to that Diamond Rio and loved running instead of using my tape player to make running playlists. I remember some type of way to reencode the mp3's in Windows on the fly to fit more on the tiny storage.
I think Apple getting their connection into aftermarket car radios at the time was a big factor in a universal standard which made having an iPod almost necessary for people driving.
My standout MP3 players were the Diamond Rio and Creative Muvo 4GB. The smaller iPod mini was really nice for running though.
> home prices adjusted for inflation literally went nowhere

Yes, but what does that mean for money invested in houses? The reason this is not the same question is that money invested in houses is leveraged, at least in the short term.

Simple example of how this can work: You buy a house at 20% down and an interest-only mortgage with a fixed interest rate of 4%. Inflation averages 3% and your house's price grows at exactly inflation. You live there for 40 years and then sell. To make our numbers simple, let's say the initial price was $100k.

So you put $20k down and take out a $80k loan. Each year you pay $3.2k in mortgage interest.

The price of your house after 40 years is, in then dollars, $326k. You sell, pay off the $80k loan, and have $246k left.

Let's consider the alternate situation: you rented for those 40 years. How much did you pay for rent? Chances are, it's no less than the interest on your loan (if only because a landlord would have that interest _and_ other expenses). In practice it probably went up over time, unlike your payments, but let's pretend it didn't. You invested your $20k downpayment in the stock market. What nominal return do you need to get to end up with $246k at the end of 40 years? The answer is about 6.5%. If inflation really averaged 3%, then that's a pretty decent stock market return, and that's all assuming that the capital gains treatment of the house and the stocks is the same (it's _not_ in the US; houses are exempt from capital gains tax to a large extent).

Obviously if you actually pay off your house all this goes out the window. ;) Likewise, if the house goes _down_ in price the leverage acts against you.

Realistically, houses are an awesome investment if you buy at a time of low-ish interest rates, and then before you've really paid off a large fraction of the house inflation spikes. If house prices simply keep up with inflation in that situation, you can really win out. People who bought in the US in the 60s and sold in the 80s or 90s did quite well, on average.
Well...yes, but in your other comment, you said that it would be difficult to run on your computer. You seemed happy when Dakull mentioned that the GOG version would be trouble-free, and then you seemed disappointed when you heard how it would be done. That confuses me a little.

With the current Dosbox defaults, the game installs nicely, is easy to configure, and runs well. Based on getting the demo running just now:

Extract the files somewhere. Mount the directory in Dosbox. Mount another directory as an install location. Run the install (the demo's is just install.exe). The installer drops you into the game directory when it exits. Run setup.exe. Select Sound Blaster for the SFX, and either Sound Blaster or General MIDI for music (personal choice). Save the configuration and exit. Run the game (blood.exe). Oh, I also set it to 800x600 resolution, when given the option to set a display mode (it's available under the VESA setting).

I see Blood available on Steam for $4.99, on GOG for $5.99...or on Ebay for various higher prices, if you really want the hard copy and the classic-ish setup experience.
I love libraries! I wish they were more prevalent. Sometimes I just want to study something outside of my apartment and there's no where I'd rather be.
Cigar lounges and boxing gyms.
The University of Waterloo Service Tunnels
Thanks okwme -- I'll check out Edax!
Suppose Western Union brought back its telegram service together with a mobile app for requesting telegraph transmissions. Would they not be allowed to use the word telegram?

ADD: What about Telegram Messenger? Does Instagram have beef with them? (Aside from disallowing Telegram links in user profiles.)
No I think the person I was replying doesn't know that the article dismisses the conspiracy theory. I might be wrong

> I have no idea why this laughable article/idea persists
Yeah, I use everything from jalapeno pepper to Carolina Reapers and everything in between at various times. I never make anything that's just plain loaded down with nothing but reapers, but I use a mix of peppers to make things that are really hot but also have a nice flavor. The heat just makes things interesting, but heat for its own sake isn't very interesting to me. You could buy pure, refined Capsaicin, but what's the point. It would taste disgusting, like "Dave's Insanity" which is hot but nasty.

Here's a neat trick I like... combine Scotch Bonnet peppers (or pepper sauce) with the hotter stuff like Ghost Pepper, Trinidad Scorpion or Carolina Reaper. The Scotch Bonnets aren't terribly hot (a little less than Habanero) but taste really good... and then just a little bit of the other stuff to jack the heat up leaves the nice flavor while still making you sweat.
When the iPod released, I remember thinking that Apple was tremendously overvalued. I did back of the napkin calculations and couldn't see iTunes + iPod sales supporting their market capitalization. Obviously, I was very wrong and I often remember this whenever I evaluate trends. I could not anticipate one of the most lucrative investment opportunities right there in front of my eyes.
I can only hear down to exactly 27.5Hz, maybe that's why I prefer 440Hz, as it's a multiple of 27.5Hz. /s
Thanks sazers - did you try the different 'Themes' and 'Palettes'? You can toggle through them via the 'Settings' dropdown on top of the page.

Also, do you have any favourites on colorhunt.co?
Weird because POS tagging takes linear time in the number of words.
That jibes with my experience. Leaving the seeds in seems to create a hotter dish.
You are right about SMILES. We trained on the canonical SMILES output by the RDKit, so as far as our AE is concerned, there is only one way to write SMILES for a given molecule (http://www.rdkit.org/docs/GettingStartedInPython.html#writin...). Of course, the choice of what the canonical SMILES is is somewhat arbitrary.
I think one of the biggest potential for molecular autoencoders is that they can be used to generate inputs for virtual high throughput screening campaigns to predict new drugs. The idea would be to train models to predict compounds that can be evaluated with more physically realistic molecular docking simulations --> in vitro activity assays --> animal models --> and then clinical trials as it goes through the pipeline.

Here is an example from our lab using virtual screening to develop PZM21 to treat pain [1]. where we screened 3M compounds. We would have liked to have screened 10^6 fold more compounds to cover easily synthesizable chemical space in this as well as other campaigns, but that is currently computationally infeasible. If molecular autoencoders could help us more efficiently screen this space, it would be huge.

I'm co-organizing a free, 1-day workshop for deep learning for chemoinformatics at Stanford Nov 11th. We've got ~75 mostly computational chemistry researchers coming. I would love to have more machine learning researchers come as well. The website is deepchemworkshop.docking.org, or PM if any of you think you may be interested.

[1] Manglik, et al. Structure-based discovery of opioid analgesics with reduced side effects (doi:10.1038/nature19112)
Definitely reefoctopus - if there are other players online, you can challenge them or simply create a match with no bots and allow others to join
The ads on both platforms are primarily useful for gathering a following local to the platform. For example, on Facebook, you want to buy likes/engagement with your page, not outbound stuff. On Twitter, you want to buy followers. Once you have a following, you engage with them and use the content you post to drive them to your site where you (presumably) make money from them.

The ads on the social platforms are not worth anything if you're using them as general CPC ads to try to drive traffic to your site. In fact, I've found this is even true for Google/Adwords.
Currently using Sinatra in my latest side project. I realize it's no longer the heyday of Ruby, but for simple apps its easy to get started and enables the possibility of using the vast amounts of Ruby gems in my project.
EDIT: world-wide market share (that I didn't find good numbers on in first search) also was (to) surprisingly high, so my impression was clearly wrong. Still interesting that such a specific device (and thus market segment: expensive mp3 players with hard disks) dominates so much.

I honestly can only name 2 people I know that owned iPods of various kinds, in an era where nearly everybody around me had some kind mp3 playing device.
They specifically said if I removed Google Sign-in and replaced it with Facebook sign-in or something of my own I'd be OK.
I'd love to show my kids how mine worked - there's a few dial up BBSes out there still - but I don't have a landline and I've only heard bad things about attempting to use a modem over a VOIP service... and there's the little problem of plugging an old telephone into a PC to access that VOIP service in the first place.
Fascinating. Thanks! At one point I wrote a unit conversion program before such things were ubiquitous and I included a field that had information about the units involved. In service of this, I copied a number of older books on measurement units though I never got around to folding most of this into my program.
If there's no appetite, you can make one. See media coverage. See media coverage before the Iraq invasion. See any of the many examples from history.

Nobody knows, but I have a strong feeling that you're gonna look back at that comment in a years time and feel pretty foolish about it. Her stint as SoS showed you all the evidence you need of her hawkishness.
That's the first one I had, a 128MB version I think. Great for riding a bike with because you could operate it without looking.
Sorry for the confusion. I wasn't aware that a rowhammer attack could be carried out even in a high-level language like JS.
There have been some recent papers in subsets of genomics with a bit more data (Transcription factor binding, for example [1]). You're correct though, definitely depends on your problem.

[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908339/pdf/btw...
Thanks for the great answers here. This definitely provides a lot of context to how you're positioning the fund. Some of this was signaled by the round size, but certainly didn't want to assume any of that.

Really hopeful to see Bryce's model work, as well. Am keeping an eye out to see if your fund experiments with similar models.
I still maintain that screwing over client developers had something to do with it. At the very least it didn't help them "control the twitter experience". Every time I see one of their new ads about how much Twitter loves developers I laugh out loud. There is zero chance I'll ever integrate Twitter into anything I do, period. I'll fight against it anywhere I work and encourage all my peers to do the same.

Did everyone forget they didn't even invent the word "Tweet"? Nor did they write their mobile clients. They had no idea what they were doing and stumbled into success. Then the MBAs turned around and stabbed us in the back.

Twitter can fuck right off.
And think about how much this costs Twitter! The Fabric SDK allows apps to do phone number verification (SMS/Voice calls) for free. This is usually the single greatest cost associated with running any app that does phone number verification (often even above engineering salaries). Multiply the number of SDK users by the cost of SMS/voice delivery, and that's a ton of money out the door every month.

There were some rumors that Twitter has tried to spin off Fabric into another home, but it sounds like potential buyers balked when they saw the costs associated with it.

The prevailing theory is that Twitter originally saw this as a way to collect user data in the mobile app paradigm in the same way that the Twitter "follow" and "tweet" buttons do in the web paradigm. It sounds like it hasn't paid off, though.
Yeah, it's a symptom of the way that companies are valued on the open market. No one can be content with well enough as long as our pricing and ownership models work the way they work.
"You are very impressionable I see. The only lens you have to view this war through is the one you're allowed to see, and you believe it!
"

There is more than enough evidence to show that Assad has, in fact, been methodically bombing bread queues and hospitals.

Maybe that should bother you more than the media reporting on it.
I skimmed it, but I didn't see much of a point except that he seems to be implying that poor people are more likely to be less intelligent (or rich people are more likely to be more intelligent).

So, let's say his analysis is correct. What then? Does it mean that we should, as a society, test for intelligence early in life and subsidize incomes appropriately? Or, just let the poor suffer if they don't have the correct genes?
The way to stop rents from rising is simple: Make sure there's enough new supply of housing to meet new demand. A lot of people are moving to the Valley but environmental / historical / construction / neighborhood regulations slow down new housing because existing residents don't want their neighborhood "ruined" by new residents and traffic. Attempting to solve rising rents by legally regulating what the market can charge is not a great idea. It will be even harder to find a vacant apartment as people hang onto their rent controlled units, and landlords will have a big incentive to find a way to throw people out of their homes to collect a higher rent as prices rise. Basically existing residents get subsidized as new people trying to move in get fucked over, which works perfectly for politicians who are not elected by people who don't live here yet.
> Also, when you serialize logic, you leave yourself handicapped to fix code bugs, as your code bugs are now data bugs by definition.

This seems to be an orthogonal architectural problem. If you need to be able to reprocess after changes to logic, chances are that you are storing your original source document somewhere and can retransform if necessary.
I've had the same pet project rattling around in my head since ~2007. It makes me sad that someone hasn't stepped in and done the work to make it a reality yet.
Bay Area Rents Are Falling
I would suggest that, at first glance, your structure is actually preferable for most applications where this would be useful. The real advantage of a DSL is when it provides a concise way to solve a specific problem domain. The OP just provides a verbose way to describe a general problem domain, without any benefit of regularization.

Your schema, on the other hand, uses explicit node names and types, which should make automated analysis much simpler and less error-prone. The few changes I'd suggest are mostly just cosmetic: standardizing the schema (the type radio seems to imply the operator equals), renaming properties (why selectedOperator when just operator will do?), and maybe compressing levels where appropriate, for instance the query-builder-group could itself have the logicalOperator property.
The point of my comment was that, yes, this kind of policy would be good and might have stopped this attack.

But it wouldn't solve the whole problem, just make it a tiny bit more difficult for the attackers. Definitely worth doing, but we will need to address the culture of 'ship and forget' also or we will just have the same problem but with software exploits.
Physical RAM attack can root Android and possibly other devices
Presumably the parent meant a stock whose share price tracks inflation in spite of its dividend. So if you reinvest the dividend, you beat inflation and potentially beat the market, depending on the dividend yield.
Please do post what happens now that you've raised the issue with the resolution centre. I look forward to seeing how they justify this.
Resiniferatoxin
Someone with PZM21 knowledge! Intriguing! Would there be any point to using low-granularity approximations of 'disjoint-class-ish' molecular backbones and building upon best candidates, doing some kind of low-res hill-climbing in effect, before increasing granularity with the best ones?

Granularity might be some kind of "well we need some kind of phenol or phenol-derived ring here, why not just replace that with some sort of representation of 'phenol-like-ring-here'" or something to that effect.

Also, about PZM21 -- will it ever experience the same fate of U47700, or the likes of the orphaned opioids resurfacing from their watery graves?
Sharing links is so common that if you want to punish users for that you can't run your business anymore.

But yeah they shouldn't login on sites that the password isn't auto completed for.
Don't worry about it. We all understood what you meant. I couldn't pass up the opportunity for a pun though.