skysight-inc/HackerNews huggingface dataset:
I seriously doubt they would be handing out 1mg doses like candy if it was as dangerous as you suggest. China has actually been quite strong with controlling potentially fatal drug distribution in the last 15 years, tightening rules for many substances. The key reason is suicide prevention. Wikipedia says "Although it is commonly believed that administration of adrenaline may cause heart failure by constricting coronary arteries, this is not the case" https://en.wikipedia.org/wiki/Epinephrine#Adverse_effects

(Edit reply to a3n below: My point was that it's not as dangerous as you are making out, not emotional appeals and cultural norms for responsible parenting. Self-administration: good enough for 3 billion+ in China/India/other developing world locations, good enough for me. The whole idea of stabbing yourself with a fat dose of adrenaline is pretty hackish anyway and shows how undeveloped our medical knowledge still is.)
Show HN: The 'stackoverflow' for startup marketing
Just thought I'd share this with the community. We have more than a dozen experts on things like PPC, SEO, SEM, enterprise sales, analytics available to answer questions on demand.

It was created with the technical founder in mind. Please let me know what you think.
From what I have read there may be more to it than just laziness and over-eating.

http://www.scientificamerican.com/article/babies-have-a-micr...

It seems to agree with my observation that many people get obese very easily while I would have a very hard time even if I tried.
I can't move past the son's crime. It is horrific sadism and violence. Read about Yu: http://www.wikicu.com/Minghui_Yu

Why should we delude ourselves that he is genuinely remorseful or that he will redeem himself for such a horrific crime? Some criminals reform, others don't. It is a mistake to assume that everyone can or will mend their ways. One consequence of the article's theme, the fact that we don't fully control our destiny (absence of free will) is that the likelihood of recidivism is high.
While I agree $300 is a ripoff and takes advantage of how medicine works in the US (i.e. the cost for most users is opaque b/c insurance pays) I can also see that $30 is not likely a viable price --just like I can put a sandwich together for $3 doesn't mean I can run a profitable sandwich shop selling sandwiches at $3.

As a consumer I could see this for $75 - $100 retail (and some discount to institutional buyers) but $30 is probably not viable and of course $300 is ridiculous.
True, and a good point to make. My understanding of the difficulty of the atomic bomb was that everyone knew what to do (smash enriched uranium together such that was more than a certain mass), but they had a lot of difficulty getting the spherical detonation right. So the problem wasn't unknown from the physics side, but was rather an engineering problem. Compare to "cure all diseases," which we don't even know how to do theoretically.
The masses do not live in Europe, the masses do not live in developed countries.
Who else would work those jobs if not Norwegians? It's implied if they didn't another group would do it.
Interesting. One thing that I still haven't solved yet is the "break" and "continue" statement inside loops. For a break statement, it seems like it would just be the same a JMP with an address as the operand, but there would need to be some sort of registration of "The VM is in the loop now, and the break address is X", and continue would also be a JMP with an address to the top of the code for the loop.

I haven't implemented those in my system yet, and also have no idea how Python or PHP does it.

Is PHP's VM a stack based one? I do read the Zend/ directory of PHP's source, but it is really hard to follow and there is virtually no documentation on the VM
There is not a free version. There's an evaluation version that doesn't lock out any features, but it's not provided to you for free -- you have to pay to continue using it. If you're just using it as your text editor for free you're abusing the honour system.
Is this sarcasm or...?

The difference between those two numbers is 0.09 GB. 0.09 is 3.8% of 2.35, or 4.0% of 2.26, so whichever way you look at it, it would be correct to say the difference is "within 5%".
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The symptoms, abnormalities, triggers and cures match perfectly with what you would expect from exhaustion due to chronic stress.

If you didn't know it was caused by a virus, you could say the same thing about having the flu, most autoimmune diseases, etc. ME/CFS causes many consistent and characteristic symptoms that aren't fatigue, and most other chronic diseases cause fatigue. Why should ME/CFS be psychosomatic any more than any other illness for which we don't know the cause?
He read it as 5% of (like 2 is 5% of 40) instead of within (i.e. accurate).
Oh I don't disagree at all. But that has very little to do with whether or not it's ethically responsible to propose an untested method for constructing a device that would only be needed in life-threatening situations.
New Record Low Solar Price in Abu Dhabi – Costs Plunging Faster Than Expected
I disagree. It is very easy for me to modify Linux. I just don't have the skills to do deep modifications. I used to compile my own kernel. Even made modifications to it. None were worth keeping.

And i don't think languages really help here. Given that many advanced languages have products that are, again, beyond me.

Directly, what sorts of edits do you wish you could do, but feel prevented from doing?
If the product is so expensive, and someone can make a competing product for less viably I find it hard to believe that it hasn't been done. A more fair comparison would be "medical aid which wasnt subjected to the same regulations and testing is cheaper to make and distribute" aka Corporate greed.
I can see how a lot of things could go wrong with things like a DIY X-ray machine or CAT scanner. And also simpler things like infusion dosage etc.

That stuff does go through FDA approval in the US, right? It's not all for nothing.
Pedantic or simply oddly foolish? That's not a precise statement at all. The concept of humanity-as-a-disease makes no sense outside of a highly misanthropic and Stockholm-syndrome-ish view of the world. "Earth" is not a sensing entity, for one, so you cannot commit moral crimes against it (i.e, bring forth to it the very real suffering that a human experiences from a disease), and it's also the source of both humanity and disease in the first place. We have diseases because "Earth" runs a process by which various creatures are continually created and torment each other to figure out who survives better.

Removing humans would do nothing more but restart the misery process again, until another intelligent vehicle appears to try to resist it, assuming that intelligent vehicles are a low energy state that evolution-style processes like to reach. Such a vehicle is our best bet for the disease truly going away. The intelligent vehicle, of course, will be highly influenced by the natural world it came from.

You could go for a Sargeras-style crusade and decide to extinguish all life in the universe and make all planets uninhabitable so that nothing can ever evolve again to cause diseases anywhere, but you would still need such an immensely powerful vehicle to enable that that you could as well stop wasting your time and make utopias instead because if you can handle FTL travel you can handle some microbes.

> But in the history of the world, every time you conquer one disease, a worse and scarier one seems to fill the void.

There are plenty of awful diseases people used to get from unsanitary conditions, malnourishment, and direct contact with nature that we don't talk about anymore because nobody gets them in first world countries or because they have been eliminated.
If you're injecting with a traditional syringe, you can see how much you're drawing into the syringe, and presumably can create an accurate dose. Assuming you aren't untrained and panicking.

The idea behind the auto injectors is accuracy with relatively little training and skill; a parent can do it while they're watching their kid strangle. That's why you buy an auto injector instead of syringes.

Competing auto injectors have not been as accurate and simple to use, is what I've read.

I would not trust my kid's life to a hacker injector; these are medical devices that are required to go through trials. Even traditional syringes are regulated. Sure, maybe you can decide to use an unregulated injector; I wouldn't, not for my kid.
I generally agree that there is more to it than the actual drug, but "epipens" aren't exactly dosing by weight.
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The OP specifically mentioned "immune" and "metabolic" dysfunction, not symptoms. You are correct that postexertional is likely common to all CFS sufferers, although even that isn't fully agreed on and there is no way of objectively measuring it (repeat CPET might be an objective measure, but that needs more research).

Neuroimmune exhaustion has not been objectively defined. The ICC says "rapid" malaise, but it's typically 24 or 48 hours later.
How is this true of the Gates Foundation? Or Good Ventures? Chan Zuckerberg is specifically aimed at improving equality. Do you have any actual examples of wealthy philanthropists using "the rest of us" as guinea pigs to cure themselves of disease?

ryandrake's point is an important one, but I don't think this level of cynicism is justified.
Even if a Turing machine were a physical object (I had thought you would be aware that it's not), either one of those moves completes before the other, or both complete simultaneously.
When I first started using Sublime, I disliked the occasional popups, and thought I'd just keep using it without paying $70 for a text editor?!?!

But I HAD to buy the thing! Not because I wanted to avoid the annoying popup, but because of everything we know about Sublime today; performance, simplicity and intuitiveness of the UI, packaging system, etc.

The article mentions that they're coming out of beta in the near future! nice! and I just noticed they're already mentioning sublime text version 4 (under sales FAQ page).
I had some excellent results with selegiline / Deprenyl in my 20's, Cyprenil (liquid) seemed to be the best. I had mad cash back then and could afford to spend money on life extension and cognitive enhancers. It certainly helped me focus.
Sounds like bunk. Optimistic<--->pessimistic is obviously a complete axis, which can have envious and trusting people on it all over the place.
Just saw more Epipen Congressional testimony. The actual unit cost of the Epipen (whether branded or "generic") is around $67 USD. Assuming that this cost were not overly inflated beyond actual overhead and unit costs, in order to be sustainable, a reasonable retail price without distributors would be $134 USD... with distributors $200-238.

That said, the more downward pressure from competitors (commercial or nonprofit projects), the better for customers; especially where a monopoly existed, it's rational to for customers to band together and attack excessive hegemony.

Enteprising folks need to jump on this to sell this as a kit (w/ or w/o the medication).
But it's profitable to sell sandwiches at $6 - that's the whole point.
Yup. The FCC fined Verizon $1.35 million for using supercookies without users' permission, which is unlikely to change the behavior of a company that paid its 4 top executives over $40 million in total in 2015.
So, what is the inductive invariant in that simple algorithm?
The price went up because Mylan got a monopoly on epinephrin auto injectors, they have that monopoly because regulations prevent would be competitors from swiftly and/or economically bringing competing products to market.

Nobody has to buy an auto injector. Diabetics draw insulin from a vile and inject themselves all the time, those with severe allergies can keep viles and needles too. I buy EpiPens because I don't want to do that. And before Avi-Q was recalled, I bought those instead, even though my costs were twice as high, because I liked them better.

You can say that capitalism is the wrong way to produce drugs, in which case its Congress' fault for not instituting a different way. Or you can say this is a failure of the regulated drug market to produce a result in the public interest, in which case its Congress' fault for not regulating the market differently - thats what I believe. If you're arguing that this is a moral failure of the Mylan stockholders… well I think thats a hard position to take, and no matter what demonstrating that auto injectors aren't expensive to build doesn't really try to make that argument.
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This is a required hw assignment for a freshmen class @ cmu. https://www.cs.cmu.edu/~fp/courses/15122-s11/lectures/23-c0v...

Given it has some parts already written in the interest of time...
New ACL surgery could cut rehab and recovery time in half
Update: Visited his page again. He has now even created a web server for the PCJr and ran his site on it for a while.
I think you're missing his point. Many people in oppressive regimes, including oppressors, are interested in a bit of extra privacy. Regime might even be able to get around it since a lot of "privacy" tools are bullshit. A tool saying it's specifically designed to defeat oppressive regimes is practically an attack on them. Even possessing it says you're fighting the regime. So, eliminating all such tools or people using them is a logical response for oppressive regimes.

And people on Pieter's side of this issue probably think it also logically follows to prevent that mental connection from happening in government officials' minds. Just gotta change how it's branded.
what are some good flickr alternatives for when they fully nix the product (store and manage all your photos)?
I think we'll create superior bodies for humans that disease never had a chance to adapt to much faster than we'll be able to figure out how to make immune systems communicate without also promoting adaptation from surrounding diseases.

Fixing the existing body is nice, but you're forever limited by what nature intended, and what it intended is just not very good.
Schools aren't required to carry EpiPens, at least not in my home state. They have, however, recently been allowed to carry them.
Actually, I'd rather see the system be corrected than a bifurcation in deaths due to anaphylactic shock according to income level, because Mylan decides to just accept the deadweight loss of poor DIY'ers instead of lowering their prices.

That said, USG may be too beholden to Big Pharma at this point for anything to be done.
simple gorilla marketing ... nice try ^.^ ... no sale
> The disturbing level of contempt is almost the sole property of the "Linux == Freedom" crowd.

That's patently incorrect and you know it. FYI: You're showing that kind of contempt right now. My point isn't even related strongly to Free Software; it was an observation that a lot of people don't like early warning systems, which is bad for security. Shooting the messenger when they bring a warning of a possible threat is a terrible idea if you want to continue to receive warning messages. Deciding if that was the goal for some people is left as an exercise to the reader.

> I mean seriously, the level of outrage about systemd alone is off the rails.

Off topic and irrelevant, though if you actually read the real, substantive complaints against systemd they tend to focus on forced upgrades from unnecessary tight integration between components and disruption of working code. The contempt in these arguments is usually from the people that try to shut down any discussion that isn't blindly accepting systemd.

> Bring up Microsoft and I'm somehow complicit in oppressing people because I use their software?

I never said anything of the sort. Pretending to be a victim is unbecoming.

> [stuff about rare earth minerals, the defense budget, GPS]

If there is a point to this word salad, I am not parsing it. It seems off topic?

> I used to be such a hard core Linux fan when I was younger.

Some of us still believe it's a bad idea to sacrifice your principles for convenience and a few shiny baubles.

> people complaining about this really make me think that we are all so isolated in our little worlds

The future will be shaped by those that control computation and the internet. This means defending computation and communication that isn't controlled by one entity is one of the most important tasks of this generation. In the future, everything is a computer. Some of us think it's important to fight for freedom now, before that happens, because the problem is only going to get harder.

If you've given up that fight, that's fine. Just please stand aside because other people are still trying to fight for a free and open future.
By “recursion”, I didn't mean a “recursive algorithm”, but rather “induction on the loop counter” (a proof technique). Since proofs aren't meant to “run”, they don't need to “halt”.
That's kind of a deal-breaker for me. I rely on shortcuts with a virtual hyper key that it would be painful to lose it.
>Why should ME/CFS be psychosomatic any more than any other illness for which we don't know the cause?

Because, as I mentioned in my parent comment, the "symptoms, abnormalities, triggers and cures" match stress, but the flu does not. (Flu and other infections typically have the opposite, i.e. increased HPA axis rather than reduced, for example).
GP probably missed the "within".
It may be better than having no epinephrine at hand. But other than that, there are a lot of problems: How sure are you that it will work when you need it? Can you fill the syringe cleanly enough? Will the epinephrine in the syringe degrade, or worse, develop a bacterial growth?

It may be a better Idea to look into a syringe+vial combination on hand, prescribed by a doctor. Less convenient, and you need to learn how to use it (and preferably teach those close to you), but this may be a whole lot safer. The downside of course is the problem of self-administration when in anaphylactic shock.
Wrong. My hand is in a splint after arthritis surgery, so I can't type much here, but see any reliable online source about the "Big Five" theory of human personality to find out better information.
> How do I make the case to my company that this is a worthwhile investment?

By helping them to understand how all of the following will work:
* User acquisition
* Ongoing costs
* "fit" with the larger business
* Making lots of money

> what's to stop someone else from...

The incredible pain of building, iterating and growing a real business. Unless you are spectacularly successful, so much so that your success is visible to lots of people, no one is going to bother. If you are so successful that someone copies you, you can tackle that very fortunate problem at that point. The chances of getting to that point are very low.

> Why does anyone pay the $100? I am baffled.

Because the company that creates the software, writes blog posts, speaks at conferences, does the marketing for the product and leads thought leadership has earned customer trust. Trust that they know the software, understand how important it is to your business and can be relied upon.
I've been using 500px lately for my publicly available photos. Seems to be the most popular alternative.

For private stuff I am hosting the originals on my own NAS and upload a copy in Google Photos for easy searching.
I'm not following the celebrity bit. You're saying we are seeing through the illusion of authenticity because of a wall of mirrors released by the Internet? I get that it's a metaphor but I don't understand what you're getting at.

What's your definition of real? I ask because when I think of single speed bikes, the first thing that comes to mind isn't real, it's what a pain in the ass. Just because it's a throwback doesn't make it more real. Get a real bike! No I don't think anything at all. I'm in fucking Oregon. I'd go nuts thinking.

And is the reason you're having trouble navigating people because they have the illusion of becoming one of the Greats or is it you that has that illusion? This is all intriguing but a bit obtuse.
The DOM isn't slow, you are. (2013)
Right, but it also breaks official microsoft windows media. How much sense does that make?
The difference is even smaller if GB are
power-of-2 Gibibytes: 2345MB is 2.29GB.
You can fix all the bugs in the fifty-year old software project... by writing a new version of it.

Sometimes the right solution doesn't deal with existing problems but tries to go somewhere else entirely.
Instagram. You can use hashtags to organize your photos similar to Lightroom and tag your friends to keep track of who's in them. I also found out if you use the hidden "Full Ten" filter it retains the original quality.
The price was raised so the CEO could escape the rigors of just scraping by on $2.5M. The board wasn't going to give her a raise without a boost in profits. That's easy to accomplish when you control 90% of the market. That is the only reason. Not production costs. Not future losses.

I bet their cheaper "generic" packaged version will see limited production to force supply shortages and drive people back to the overpriced pens.
I wasn't previously acquainted with the term "operationalization" as used in this sense.

Okay, it may turn out that this categorization is no better than Humourism, which seem to have suffered of the issues of poor variable operationalization as you described: ancient doctors frequently heaped together distinct phenomena ("hot" meant anything which was hot to the senses, whether it was a glowing hot iron, a flesh wound or a bowl of Jalapeños). But I don't think it's quite the case here: they're grouping users by their choices in a game. That's well defined enough, isn't it?

The names don't arouse any suspicion to me, either. I think it's just a case of researchers trying to "sexy up" their findings. It's something that might happen almost involuntarily: either because they started with a sexier model in their minds, or because in seeing their findings, it just came up to their minds and stuck there. I'm actually rather hard pressed for real examples right now, besides calling the transfer of a quantum state "teleportation" (because I just readn about that today), but it's something that happens quite often.
I've heard that law enforcement uses X-ray machines to look at vehicles on the road, without even asking or informing the drivers they are dosing with radiation.

Funny enough, these devices don't need FDA approval, since they aren't medical devices, and the operators don't need to know anything about radiation effects on Humans...
Epipens come in a grand total of 2 sizes to cover everyone from small children to very large adults, I feel like the precision of the dose isn't that important...
I (sincerely) wonder - what would happen if USA were to receive such a short-duration windfall? Will it be socked away in a rainy day fund, or will it be spent immediately in terms of infrastructure programs, or welfare programs or tax cuts/rebates?

In fact, California experienced such a windfall due to rising stock prices in recent years, and Jerry Brown had to fight with the legislature to save that in a rainy day fund instead of spending on welfare programs.
I read Dave Kerpen's New book. Got an Idea and made it. Here it is
If I buy a microsoft windows laptop, I don't expect it to be locked so I can't install.... microsoft windows.

How else am I going to avoid the crapware/malware that lenovo is famous for?

Happens that the same BIOS tweak that prevents windows from working also prevents linux from working.

I don't expect lenovo to spend time/effort accommodating linux, but I also expect them to not artificially limit when I can do with a laptop I purchase.
The best part of Firebase hosting is the free custom domain support + CDN + SSL cert. HTTP/2 is icing on the cake. Nice job!

(Disclosure: I work for Google)