skysight-inc/HackerNews huggingface dataset:
Yes-- the inheritance of mtDNA is maternal, but interestingly not 100% of her children will inherit the disease. This is because the mother will have a mix of mutated (diseased) mtDNA and wild-type (healthy) mtDNA in each of her cells, including her eggs. Some of the eggs will have close to all mtDNA mutated, but many will have a relatively low mutational burden. (This variation amongst the mother's cells and eggs is called heteroplasmy). Most mitochondrial genetic diseases have a heteroplasmy threshold (varying by gene/pathway, between 30-90% for many); when the overall burden in a fertilized egg is above this threshold, the disease is manifested in the offspring. Thus, another way to circumvent the transmission of mtDNA diseases is by using regular in vitro fertilization, and checking one of the cells at the 16 or 32 cell stage for their heteroplasmic content.

Here are some references:

Lightowlers, R. N., Taylor, R. W., & Turnbull, D. M. (2015). Mutations causing mitochondrial disease: What is new and what challenges remain? Science, 349(6255), 1494–1499. http://doi.org/10.1126/science.aac7516

Taylor, R. W., & Turnbull, D. M. (2005). Mitochondrial DNA mutations in human disease. Nature Reviews Genetics, 6(5), 389–402. http://doi.org/10.1038/nrg1606

Smeets, H. J. M., Sallevelt, S. C. E. H., Dreesen, J. C. F. M., Die Smulders, C. E. M., & Coo, I. F. M. (2015). Preventing the transmission of mitochondrial DNA disorders using prenatal or preimplantation genetic diagnosis. Annals of the New York Academy of Sciences, 1350(1), 29–36. http://doi.org/10.1111/nyas.12866
Maybe I'm misunderstanding but you seem to be saying "Let's not be excited about colonizing another planet-- life will be just as depressing there."
Only on the outside. Let it also stand still on the inside and the results will be different.
It seems you don't actually understand the complaint, and are resorting to a schoolyard "no you" tactic to try and deflect.

The problem is that this merge option is considered by many to be actively harmful, and GitHub adding support for this is basically them tacitly saying that this is a perfectly fine merge method to use. This will almost certainly cause an increase in the number of people using this merge method, which is a shame as it really should be discouraged instead of encouraged.

The other problem is the main argument in favor of this merge method is the fact that GitHub displays non-linear commit histories terribly. That should not be an argument in favor of having a poor merging strategy, that should be an argument in favor of GitHub revamping their commit history display to actually be useful.
I was very much annoyed by the movie when I saw it. Primarily because the "genetically inferior" person somehow had more motivation and drive than the genetically engineered ones.

So perhaps they were not so much genetically superior? Maybe motivation can be passed through DNA?

In reality, what I think might happen is some people would choose the genes they want, but others won't. At the end, people will mix, so the whole population will benefit.
They abandoned Persona because nobody used it and it cost money to operate. They tried promoting it, it wasn't enough to overcome social media SSO. I hate it, but they just lost.
Wonder if it's possible to have a 'NATO like' alliance among the smaller companies that pools the resource together to fight patent trolls, and basically make it clear that these are the companies that will never settle with you, and will utilize pooled resource to fight against the patent trolls to the end.
Owning is just so much less convenient than renting access. I vastly prefer the experience of using Spotify and Netflix to the experience of maintaining my own music and media collections.
The answer is the same as why the Falcon 9 uses propulsive landing. Parachutes are heavy, and generally require a water landing which seriously damages the booster (not to mention requires a recovery operation). The vast majority of the weight in these spacecraft is fuel, so when it's time for it to return to the pad it requires a comparatively small amount of fuel (as most of the weight has been burnt up). The fuel itself is also a tiny percentage of the total cost of the craft, at interplanetary scale $10k for a little extra fuel is nothing.
I wrote a long essay about this that I have yet to publish, but my basic point is this:

1. Mars is a fucking desert. There is no air, water or life.

2. Venus is covered in CO2 clouds and sulfuric acid rain. Metal melts on its surface.

We are not going to live in space. To even WANT to live in space is an absurd fantasy that is in violent conflict with the reality of space as an airless, inhospitable, largely resourceless wasteland that requires enormous effort to travel through and survive in.

Why, then, does Musk insist we need to live in space? I think this is simply an update of our previous desire for an afterlife or a heaven. Since we are no longer willing to fantasize and organize around the Kingdom of Heaven, we've turned space into the Kingdom of Heaven, despite the fact that it has very few actual heavenly qualities.
The idea is to be a multiplanetary species. Not leave Earth for Mars. Plus, it's just really fucking awesome. That alone is enough reason for it to be pursued imo. Exploring and doing cool new things is part of what makes life worth living.
If I had to review the choice of music they played before the presentation started, I would tell people not to buy the album
Professional Remote Administration Tool
I just turned down an offer after a technical interview. Just after my tech call, I call the hiring manager and said I didn't want to move forward.

Technical interviews aren't the problem, is when interviewers already have an answer they want, and if anything strays from it, they just flat out refuse the answer. Sure datastructure X maybe better when getting to a million items, but for most use cases, Y is valid, and when Y is a problem, I can easily google an alternative, but nooooooo, it has to be X from the start because or A B or C.

I like being chalenged in a interview, talk about various topics, but if for every question you have, you have one and one answer only, and any other that may fit but isn't on your spreadsheet is wrong, then seriously, F U.

Fortunately also talked with other companies that were more sane, but this 'My way or the highway' from pseudo engineers is what is wrong with hiring in tech.
Stupid Candidates: ‘Cyber’ Security
Show HN: I built a MySQL storage engine which is InnoDB compatible
Why do they even use phone numbers and not email+pseudonym like every other messaging app out there?

What's the use of a secure messaging app that only works between people you trust enough to tell your phone number to? If I wanted to send a secure message to such a person, there's tons of ways to do it already, including just meeting face to face. What I want is a replacement for Skype, honestly - one-to-one and many-to-many via self-chosen emails and pseudonyms.
I know unions are a popular whipping boy on hn but blaming them for today's overpriced housing? And up-voting this nonsense? wow
This one is a little tricky. The battle of Fort Sumter, which is usually regarded as the start of the war, was actually after he was inaugurated. Secession, however, started well before his inauguration in March.

In any case, the conflict was definitely there before he was directly involved.
Someone more knowledgeable then me can probably answer this, but under ITAR, can SpaceX contract a Mars launch with another nation on friendly terms with the USA?
It's in your own quote - it was on a prototype, without any power management features. Once power management features are enabled, it will last longer.
Unless you think Google's existing phrase based system is significantly behind the state of the art (possible, but I doubt it's too far behind), 60% better is a pretty great improvement.

I only skimmed the paper briefly, but it seems like they don't depart significantly from the NMT literature, but they do need to tweak a few things to get their results.
One of the hardest things to accept about life is that there are no guarantees. You play with the hand you're dealt.
When a disk cache performs better than an in-memory cache
Can't believe we're in that moment here.
At least in Germany, where I live, there are similar regulations concerning permission to build your own radio device for CB band as for baseband processors (i.e. if you want to legally use your self-built device there are strong restrictions (CE certifications are nearly unaffordable for makers).

Also in CB bands you are not allowed to encrypt the sent data. Thus not an option for people caring about privacy.
> SpaceX experimented with using parachutes in the past (mainly for their Falcon 1 vehicles), but parachutes are poorly suited to this application, as extreme speeds and loads cause them to shred. Parachutes large enough to recover the stage are also quite heavy, a weight which could be used for fuel for a propulsive landing and for primary mission assurance. Parachutes also cannot be steered.

> Essentially, this becomes a problem of people overestimating the amount of fuel required to bring the stage back, underestimating the weight of the parachute system (which would be in the hundreds of kilograms at least), and underestimating the fragility and controllability of a parachute system.

https://www.reddit.com/r/spacex/wiki/faq/reusability
While we are already trying a hard thing of getting to Mars, why not make an attempt to get back instead of "doing nothing"?
As someone who is both a homeless woman and the top ranked woman on HN, I don't remotely agree with you.
Ohhh my god, you're totally right. I was looking at this: https://github.com/couchbase/couchbase-lite-ios
What are we going to do on Mars? Live in a plastic box? Send in a bunch of slaves to mine minerals in insufferable conditions? I don't get it.
Doing what, blowing up rockets? Shipping goods to LEO like people have been doing for literally decades?

Mars has no atmosphere. Who is going to solve that niggling issue to being a multiplanetary species? Who's even close? Musk is not "doing it".
>Changing a toner is $50 per cartridge.

What is the yield though?

I haven't seen anything that even comes close to the cost savings with a Kyocera (not to mention their machines are work horses will print all day without issue). I can get a Kocera TK 3112 toner which yields 15,500 pages (and it actually does) for $66.
Parachutes put large loads on the structure when opening and don't have much precision in choosing a landing site.
it's a fair point.
I don't have a clear memory of when I first visited Google, but I do remember using going from Alta Vista to Metacrawler, until gradually (still rather quickly) Google ended up consistently yielding good enough results that Metacrawler became redundant.
Django app to apply filters on drf querysets using query params with validations
then do it like I do. Whenever they send you a link to one, don't take it. Explain you are more than happy to talk to an engineer but you won't do some random online test.

(or if you want to be mean, take it, answer every question with a variant of 'this is dumb' and then email the company saying they just wasted their money on these systems)
You're right, there's no other work to be done except ad impressions and colonizing Mars.
There is no practical way for HP to "make amends." I would consider buying an HP printer if they gave me for free, a flawlessly-working printer (or johnny-on-the-spot support and/or enough free replacement printers to achieve the functional equivalent), and 5 years of free ink. In other words, a level of generosity and support that, if they did it for everybody, would put them out of business. Which is probably where they deserve to be. That also, would help make amends.

It would also be okay with me if the whole printer market were regulated into some semblance of normalcy by the government. (Assuming the government is competent and capable of governing the corporate class to which it is currently in thrall... obviously not a valid assumption. Everybody who was all GET BIG GOVERNMENT OFF OUR BACKS - enjoy.)
Hm. It either hasn't started yet or its not working for me. I just see the logo and hear music.
Where would somehow selecting one of the billions of sperm and one of the millions(?) of eggs for ideal genetic material and then allowing them to combine "naturally" fall?

That'd probably get you 60% of the way to full on designer babies anyway, unless you're going for a trait that's not at all in your gene pool.
We won't really be an interplanetary species until we can get back from Mars.

Imagine being colonists on Mars without the ability to be totally self-sustaining without technology and supplies from Earth and nuclear war breaks out. It's going to be a long time before any Mars colony can survive on its own.
So, are you saying that us as humans need to quit trying to get off this rock and get back to extincting ourselves here?
Mars will be our Earth's active backup, in case shit goes really bad here(or, quite possibly we make it really bad here).
> You have to distinguish the conventional (high efficiency) cycle of a jet engine at low Mach, from the reheat (low efficiency) operation usually used for high Mach.

Exactly. At high mach, almost all of the energy being put into the flow is from expanding combustion gases - not the compressor stage. If you wanted to go at supersonic speeds using only spinning fans, you will need a heck of a lot of fans. Maybe we could do it! But we haven't so far.
"Until now, nobody has been able to look inside at how one of these scams work -- especially one that's been so prolific, generating millions of dollars in royalties by cashing in on unwitting buyers who are tricked into thinking these ebooks have some substance.

Shershnyov was able to stay in Amazon's shadows for two years by using his scam server conservatively so as to not raise any red flags.

What eventually gave him away weren't customer complaints or even getting caught by the bookseller. It was good old-fashioned carelessness. He forgot to put a password on his server."
Or Jeff Gannon, the fake journalist at press briefings during the Bush Administation, the Psyops Units at PBS/CNN and the new buildings next to Google HQ, the relationship between State Department propaganda and SONY as leaked by the disclosures a few years ago, the "War of Ideas" program, the Overt Peacetime Psyops Program (OP3) out of the DoD, the NSA task to use global surveillance to measure in real time the effects of US propaganda programming, Judith Miller and others who worked with the state to sell the war, the weaponization of information in the press (the "echo chamber" Josh Earnest bragged about creating for the Obama Administration), war censorship and media imbedding laws that removes the possibility of investigative reporting on US war operations, the FBI hacking of the Associated Press, the censorship of public records in the State Department Press Briefiengs, the censorship of media coverage in Ferguson via the FAA, the engineered content in public school education textbooks and standards, the censorship of public records (such as over 80% of the Torture Program Reports), the partnership with media companies on narrative that led to both the censorship of surveillance reporting during the Bush Administration and the ouster of Snowden Document content from US media firms including social media sites like Facebook, the coercive leverage in the relationship with media companies (e.g. the bankruptcy of QWest in retaliation for refusing national security backdoors), operations like Earnest Voice to arm our military with astroturfing and persona management technology, the flood of military users and narrative into social media sites like reddit, the huge cashflows of taxpayer money into PR firms to manage public perception of the state and the police, operations like Zunzuneo focused on destabilizing countries overseas, etc.
elon musk debuts his foray into electronic music
What matters most is the amount of security effort paid to the project, not whether it is open- or closed-source. Commercial decompilers, reverse-engineering tools and automated bug finders have come a long way - a determined reverser can find bugs in closed-source code almost as easily as in open-source code. But, both kinds of bug finding take time and loads of manual effort (despite good tools), and will often only happen with appropriate incentives.

This is where closed-source has a major advantage: companies put up money (in the form of bug bounties) to counteract the bug prices that a researcher could obtain on the black market. This incentivizes "good" researchers to spend time on their products. Open-source projects, even highly-successful ones, rarely have enough funding to run good bug bounty programs. Consequently, good guys can't pay the bills finding bugs in open source, whereas bad guys get huge payoffs for finding and exploiting bugs (think the NSA, criminal groups, malicious states, etc.).

As the adage goes, enough eyeballs render all bugs shallow. But, in this day and age, that applies both to open- and to closed-source code.
It's an addiction that can be quit instantly with no ill effects using nothing more than the willpower it takes to turn down a second slice of cake. Unfortunately I can't imagine what sort of social service can teach all these progressively-more-coddled generations how to tap willpower.
That's a different and more uncertain reliability model for continued existence of the human species - at least for the probabilities I'd personally assign for the events required for getting to mars vs a serious effort at fighting climate change. (Especially given how weakly fighting climate change is supported among the two mainstream presidential candidates.)
Is SpaceX trying to simulate the long, tedious trip to Mars with this scheduling delay and "endless space" intro graphic?
Because we are a migrant species... and because of this: http://www.greatdreams.com/asteroid-map.jpg

All those nice dots are potentially dangerous asteroids :)

And also, to prove we can.
Can't sign my name to something with a grammar error:

"...the printers now automatically verify whether its ink cartridges are official HP ink..."

The word "its" has no antecedent to which it refers. Assuming you mean "belonging to the printers" then it should be "their." Though it highlights a factual inaccuracy - the cartridges are not the property of the printer(s), so maybe just say "the" ink cartridges, or better yet, "any installed" ink cartridges.
The whole process is kind of built against showing any solid plans until as late as possible. It's hard to argue against the nebulous idea of 'create more jobs' other than 'that's not an actual plan'. Once your opponent provides a solid plan you get all sorts of new ways to attack it like cost (especially cost). Another reason to not put out a detailed plan is that the actual bills/regulations you can get in office are going to look pretty different than what the base of $PARTY would like to see because you have to actually get it passed, but then you're not delivering on the promises and no one likes to hear 'we knew the proposal was ambitious and impractical to get passed but we told you we would to get your vote'.
Hilarious Interview with Two Beautiful Siberian Huskies
We need to live in space because having all human life on one planet is intrinsically unreliable. However lucky we get, every year there is a tiny chance that we are all killed by anything from an asteroid impact to global climate change. No matter how small that chance is, what it means is given enough time, eventually this planet will no longer be host to humans. We need to branch out to other planets before that happens if our civilization is to survive.

Yes, it requires a lot of effort to do it. It required a lot of effort to build the first airplanes (I can find you many, many quotes similar to yours about how 'man was not meant to fly though the air like a bird'). That doesn't mean you shouldn't try to do it.

I will also remind you that at many points in history (for the vast majority of its existence in fact) the Earth was an inhospitable wasteland. Given time and innovation we can make space a more welcoming environment.
I only noticed it when I tried Amazon and got slammed with a hundred pages of "it has a similar name!" matches. You can buy a laptop there fine, but peripherals and internals just aren't arranged in any coherent way.

I'm not sure what Newegg is doing (apart from specializing), but it works damn well.
I think he gave the Brother a fixed IP (using the admin tool on the wireless router, maybe). We didn't change anything on the Macs themselves. If he's around this evening, I'll ask.
So like the sc macro system, but more featureful. In theory, the sc macros could record this sort of data (maybe), but I don't think they record as much as syntax objects.
In my opinion, default offline vs default online is a HUGE architectural difference. You could probably try to hack it into the existing player, but it wouldn't work well.

A ground-up rewrite wouldn't surprise me at all for such a change.
Redundancy. A bad backup is better than none at all.

In addition, because I believe it is worthwhile to attempt difficult things to see what we can achieve. Inspiration is a valid goal.
Well that's some interesting pedantry, but I think it was fairly clear what they meant, and I was sighing along with them when I had no idea what time the answer actually referred to.
I think the point being made is life will be just as depressing in Mars if we are running behind things in Mars like we do here.
You misunderstood. Nowhere was it implied that we shouldn't be excited about anything.
There are actually studies that quantify some of the differences in behavior between people who are lucky and people who are not. I think the actionable advice here wouod have to do with what pre-conditions must exist before this advice is meaningful and useful. Having some idea of what kind of situation you must create for yourself first would make it easier for people to recognize whether or not this advice can be applied to their life and, if not, what personal issues need to be addressed before this is useful advice.
I guess there are two issues here:

- Most of the available texts have some form of "errors" or are not grammatically complete

- Machine translation does not care about grammar, it cares about probabilities

NLP with grammar knowledge is feature engineering basically. It is useful when you're "shallow learning" but not so much when you're deep learning
It's more like unless we are conscientious about what dependencies we include, we will have the same headaches with bloat using python as we have using ruby. And if the environment change is going to cost a very large amount, it would be prudent to see if any improvements can be made locally first as a form of low hanging fruit.
Throughout human history, there has always been a new/unexplored land to emigrate to for new opportunities or to escape political persecution. Nowdays there is nowhere left for someone in the West to emigrate to that is not substantially the same or worse. Mars and the stars could potentially offer that opportunity, which might be why some people are excited.
>Way I see it, Luckey just got a lesson in the rules.

Same for those actors who were fired during the Hollywood blacklist era. No problem with that, right? They just got a lesson in the rules.
Introducing the VR Developer Nanodegree
is anyone doing it? is anyone interrupting those who are trying to do it?
>We had to break the old whole reading method and switch over to phonics, and that was decades after we had the hard scientific evidence that phonics was the missing perspective needed to get that last percentage of students to read.

https://en.wikipedia.org/wiki/Phoenician_alphabet#Spread_of_...
Okay, 21 minutes late, the music just got pretty wicked and Hans Zimmer-esque. Sweet.
The Blind Apple Employee Who Upgraded My iPhone