skysight-inc/HackerNews huggingface dataset:
To quote from a review article[1]: "Antiseptics are biocides or products that destroy or inhibit the growth of microorganisms in or on living tissue". So antibiotics are a type of antiseptic.

>In many centuries of use, bacteria have not developed resistance to antiseptics. There's no danger of them developing resistance to these soaps either

This is not really true. In fact, the substance under question here, Triclosan, is a small 24-atom molecule so, in principle, there's no reason microbes couldn't develop resistance to it.

"TCS inhibits FabI, an enoyl-acyl carrier protein reductase (ENR). The FabI protein catalyzes the elongation cycle in the synthesis of fatty acids, an essential process for cell viability "[2]. Thus, one known mechanism of resistance is to alter the protein that TCS binds to:

"Mutation occurs whereby single or multiple amino acids are changed in the fabI gene, resulting in TCS-resistant FabI proteins"[2].

And it's not even just a matter of "well TCS is ineffective, so why not just leave it alone?". Triclosan is implicated in multi-drug cross resistance:

"In studies done on E. coli and P. aeruginosa, resistance to chloramphenicol and tetracycline increased 10-fold following TCS exposure"[2]. In addition, a survey of Acinetobacter baumanii (an increasingly common opportunistic pathogen found in hospital acquired infections) clinical isolates found that those that could resist low concentrations of TCS also exhibited "increased tolerance to amikacin, tetracycline, levofloxacin and imipenem."[2].

So in fact having TCS everywhere is actively harming our ability to use other effective antibiotics.

[1] McDonnell G, Russell AD. Antiseptics and Disinfectants: Activity, Action, and Resistance. Clinical Microbiology Reviews. 1999;12(1):147-179. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC88911/

[2] Carey DE, McNamara PJ. The impact of triclosan on the spread of antibiotic resistance in the environment. Frontiers in Microbiology. 2014;5:780. doi:10.3389/fmicb.2014.00780. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4295542/
While this is good evidence of what is actually happening, please let's not suggest, even implicitly, that publishers are a place to look for guides to best practices [0]. I don't know about the sciences more generally, but, in math, "because the publishers do it" is just about the best reason possible not to do it [1].

[0] Except maybe that they publish them. :-)

[1] Except the AMS, which, in my limited experience, seems to be populated by, and perhaps even more important, in the charge of, people who Get It.
And another one to some extent: oOo uses its own font rendering, the LO team (I gather) moved over to using libraries (harfbuzz) available in host OS for font rendering. I seem to have better results on former under some circumstances.

I have not had any round-trip editing problems flitting between the two under Linuxen of various kinds.
I don't think you can get the same collective intelligence in a small group (even composed of very bright people) as you can find here on HN.
You're not guilty just because a cop says so. You have a right to a trial for every speeding ticket. Most people just waive that right.
It would be interesting to compare how many birds are killed by flying into the windows of glass skyscrapers.

Anyhow, it's good that solar thermal will soon not be cost competitive vs solar PV + battery.
It does. Should Vancouver not act to protect its own citizens to the best of its ability, then?
Had about 10 hours of meetings this week; this is on the heavier side.

Serious question. How do other folks get collaborative work done on big projects without having meetings to discuss/brainstorm/check in/etc? There seems to be a strong attitude here of "I am working on $THING, therefore leave me alone unless it's an emergency," but how does that actually work when $THING gets complex, malleable, ill-defined, risky, changed, etc?
You don't get shares if you invest -- you get something called a "crowd safe": https://republic.co/learn/investors/crowdsafe

More info here: http://www.crowdfundinsider.com/2016/06/87034-republic-adds-...

I'm a bit leery of these. According to the article, "unless specifically negotiated, SAFE holders do not have any voting or information rights." I also suspect that the shareholders get taken care of before crowd safe holders in legal or bankruptcy proceedings. The rights of crowd safe holders haven't been tested in court.

I think the lack of rights and additional risk inherent in crowd safes would need to be compensated for by some kind of discount relative to what investors pay for shares. Otherwise, the risk-adjusted return is lower.

I would also be skeptical of the potential of a startup that can't convince normal VCs to fund them. If people who do this for a living don't think a startup is worth investing in, why should I?
The protocol prefix is a technical implementation detail. It'd be quite a coincidence if it also happened to be the best users interface.

Browser developers aren't in a position to retrain users to their preferred ideology. Their job is to find ways to make the web easier to use.

And in fact they have: green URL bars, padlocks etc. – these are UI metaphors that do a much better job than a one-letter change in a cryptic initialism from the 70'ies.

Even holier-than-thou professionals should profit from this: a green URL actually means the connection is protected, whereas it's quite easy to use https without actually using encryption or at least using completely insecure ciphers.
It took me until the end of the video to understand that by "ribble", "rupert", "rippy", etc., he meant "rubric". This does not reflect on the video, which is otherwise clear and to-the-point. I imagine the software is reasonable.
Why "surely"? One of the main things about the Juno probe is how underpowered its tech is.
Here is one.
https://www.youtube.com/watch?v=yY6s2zu4_2U
I would guess the problem is they don't even know they need to climb it to begin with. I don't think ants have enough consciousness to realize "this is the way I fell down, so this is where I have to go to get back", and the pipe wouldn't have any pheromone trails or anything to signal them. It's a long way to climb when you don't specifically realize that's what you need to do.
I think that jeffehobbs is suggesting that your call to action, rather than the facts on which it is based, should be viewed with extra scrutiny because of your affiliation.
Most of us with Aphantasia can feel three dimensional models, however. My tests show I have a high accuracy of the items I'm feeling, but not necessarily a lot of detail. It could be compared to a 3D model with no texture mapping. I will also note that not everyone's visualization systems are the same, so you may be able to draw anything, but some may not be able to zoom, enhance color, rotate, change perspective, etc. I have one friend that can move icons of things around and draw lines between them, but can't imagine a beach.
That's not really homicide though.
What actually is the Mediterranean diet – and does it work?
Sorry for the flash.

http://www.crackshackormansion.com/index.html
Dumb move by the EU.
We know basically nothing about the details of cloud structure on exoplanets.
I think it is healthy strategy to dedicate 5-10% of investment portfolio to high risks investments like this, even for average investor.
This is probably a gap in my knowledge, but I hope this isn't a terribly obvious question.

So let's say I buy a bunch of bitcoins and I just sit on them.

A year or two from now, they're worth a bunch of money, so I use them or sell them. How does everyone with the truncated blockchain know that the bitcoins I'm using aren't being double-spent?
A couple more interesting components:

* http://llvm.org/releases/3.9.0/tools/clang/docs/ReleaseNotes...

* http://llvm.org/releases/3.9.0/tools/clang/tools/extra/docs/...

* http://llvm.org/releases/3.9.0/tools/lld/docs/ReleaseNotes.h...
That's pretty special.
Both t0 and t1 loads are atomic, meaning you'll always get the whole object.
But there's no synchronization between them and another thread can preempt
the execution and change value of %ptr right after the first load.
The article is quite old, and plenty of implementation are widely available today.

Here is a link to mean shift for sklearn: http://scikit-learn.org/stable/modules/generated/sklearn.clu...
I'd imagine the audience is similar to the people that "give gold" to strangers for a funny, insightful, etc comment on Reddit.

To me it seems like the question is not whether or not people are willing, but is it easy enough to work.
I see an impactful animated film, like Watership Down, or VR experience where the reveal is you're one of these ants.
Can you explain worldview refactoring? This sounds like something I have been mulling on recently. (Concept not phrase)
This has nothing to do with the FBI or IRS; it's in London.

The UK's territories include several actual tax havens (the Channel Islands, Isle of Man, Virgin Islands, Bermuda, Cayman etc). Many tens of thousands of houses are owned by corporations registered in an offshore tax haven.

There's a map of British property registered in a tax haven: http://www.private-eye.co.uk/registry
I can help answer a lot of these questions. EventBoard.io is able to provide a ton of data & insights to better understand how your rooms are being used.

Zach Culverwell
zach.culverwell@eventboard.io
415-813-3772
I misread your comment.
It's the groups you run in.
They don't want to make a few percent on their capital?
As a former TA at Berkeley (where Gradescope was founded), I can't stress enough how integral Gradescope was to our exam process. It streamlines the process of scanning exams, allows us to grade them online, and then to easily respond to regrade requests.

It seems like they've put a lot of work towards eliminating the remaining bottleneck: actually assigning grades (which was done by a dozen profs/TAs in 10 hour marathon). Anything that automates busywork and allows teachers to focus on actually teaching sounds amazing!
7 Surprising Snapchat Secrets Every Marketer Should Know
Read this only if you want to become a VC
Haha I like the comparison between the uptick of food allergies and the uptick of adoption of the NT Kernel. I thought this was considered GRAS, despite much evidence to the contrary :D
Then it's kind of a stretch to call Jupiter "truly unique" in this respect, isn't it? "Wow, only a quarter of known gas giants are like this!"
No, no, no, a million times no. Annoy the wrong moderator and your account gets sitewide punished.

I got an account probation, after posting something a few years back about how a specific poster was being disingenuous (and this on the GBS board, which is pretty toxic anyways), and wound up unable to post for 8 hours. Haven't been back since.

That and I find "goon" humor really smarmy and tiresome :/
Sorry about that. If it helps any, it would appear Aphantasiacs have purpose here. My kids have it. We're immune from commercial and "bad image" influence as well.
They don't rent them out.

Source: am Vancouverite
Got Ur Back Security Guard Services~ Colorado
Facebook Engineers Crash Data Centers in Real-World Stress Test
It's not so much the use of an email server that bothers me personally, it's the lack of accountability and double standard afterward.

For the purpose of staying somewhat on-topic for HN, and this is entirely speculative for entertainment purposes only, but I wonder if there were deeper motives to running a personal email server. Maybe she knows something about the intelligence agencies or the state department's official email system we don't, and was deliberately avoiding (or aiding?) them. Are there any such legitimate technical reasons for running a separate email server?
Other cities are welcome to more affordable housing and extra tax revenue by introducing the same tax. Win-win for everyone except wealthy foreign buyers, no?
misleading title - there's no certainty of repatriation happening in the article.
If you think that's excessive you should try working for big government...
What are your actual goals?
Well, you could limit cars in cities which wastes a lot of space.

http://www.bloomberg.com/news/articles/2014-04-01/american-c...

But then you need to answer my question:

There must be some way to move large numbers of people over "great distances" (50-100 miles) in a more commutable time.
"An Apple spokeswoman said that Mr. Cook was referring to his optimism that the U.S. will change its tax code next year, and that his comments didn’t represent any change to Apple’s position on the question."

Not quite the same meaning as the headline.
Saturn has a tilt just a bit more than the Earth and it experiences seasons; the pole is rotated something like 26 degrees into our field of vision in "winter". Uranus is actually rotating on it's side.

http://www.setterfield.org/Astronomy/pictures/axial-tilt-pla...
My guess is that some do climb out, randomly, but not enough to be statistically significant.

Hell is not knowing that you're in hell and should get out.
Insightful maybe, but the ironic (and I'm not sure to what degree) antisemitism, nazi veneration, and apparent lust for the end of the world gets old quick.

I'd kill for a /pol/ that bans low effort posting like that.
oops, never mind :)
If only I had 10 minutes to study the science of every last thing I don't understand... I'd be getting younger by the article. There's only so much time in a day to devote to so much activity while I'm waiting for code to compile.
I agree that Make's syntax isn't ideal, but JSON doesn't seem like a move in the right direction. If you're going to give Make a new syntax, why not pick a more pleasant syntax?
@dang, or whoever's still in the office - can you change the title here to match that of the actual article? Thanks!

("Tim Cook Says Apple Could Send Cash Back to U.S. Next Year")
So it's Australia, for ants!
People (in mass) are generally stupid and public good is something that needs to be carefully maintained. Much of our regulation is around maintaining a balance between freedom for an individual against the safety and peace for everyone.

In this case, there is far more harm than good.
Samsung’s Recall: The Problem with Lithium-Ion Batteries
http://www.peta.org/about-peta/contact-peta/report-cruelty/
Well I guess Tim Cook is looking forward to Trump's 15% corporate tax next year...
Yeah it's true. This is just true of Rust in general; we've chosen to have a relatively small standard library.

At the same time, one bit that the post didn't talk about (and for good reason, it's not the point of the post) is that a strength of Rust is that Rayon enjoys the same safety guarantees as the threading stuff that _is_ built into the standard library, thanks to the trait system. Rayon will still prevent data races at compile time, just like all Rust code.
So at present, offline installation with a reasonable package selection is Debian off the shelf and Slackware with a carefully curated cache of slackbuild produced binaries.

I suppose one could cache the OpenBSD package binaries and point pkg_add to the relevant storage media to make a third option.
Is this going to get buried down on page 37 again because the comments contradict the feels brigade's self-image?

Edit: Fscking called it (http://sli.mg/HqLVu2).
Just like LambdaConf. (https://twitter.com/antispamuel/status/719907750097129473). War is peace, excluding people is inclusivity and stomping out wrongthink is welcoming.
Have an upvote. The "Note: It is allowed to cost money." reminds me that the $5 charge on MeFi filters out alot of noise. However, this doesn't necessarily promote an increase in quality. Much of the discussion can be, like Reddit, cute or snarky one-liner comments.
<1%
"right now I would forecast that repatriation to occur next year"

seems like he's dangling the money in front of the US gov's nose. perhaps the US gov will help apple avoid this huge bill from EU.
Preventing one individual from making multiple predictions doesn't necessarily solve this problem. You can do the same thing by getting 1024 people together to make a variety of predictions. At the end, one person looks prescient.
https://scholar.google.com/scholar?q=smoking+warning+labels+...
This seems like a pretty snarky way to side-step what the guy was actually talking about. That being said, this is a utopian vision which I wholeheartedly support.
You aren't actually certain. You think you're certain, based on...nothing. There's a difference.
This is not a non-story, at least for me. I didn't know about it and I find it interesting. Then again, I know 6000 is probably peanuts in comparision with, wild guess, birds and other species dying from cancer or other diseases because of the resulting smokes/particles/toxins released by burning stuff to get energy. Or maybe worse: whole species going extinct because their land is put under water to build a dam.
That's so 2013...
> almost completely stopped the practice

That is way overselling any evidence of what's happened. The tax was enacted less than a month ago. Volumes are way down right now, but the effect on prices are uncertain. I think the consensus is that people are in wait-and-see mode.
You need to get your facts straight. The FDA has had zero (0.0000) role in the War on Drugs.
What about the other directions? How many people commute from Birmingham, for example? It's only 126 miles away? That's a 30 commute sometime this century. It's really just a question of when.
The voters are the ultimate authority in all of this, and we get to decide in November.
Maybe so. At any rate, have a nice day, and a great weekend!
I think this is the first time in this thread someone actually sat down and explained why it's worse instead of just waving it off. In fact, until now, I was even on the self cert side of the debate because the arguments seemed more thought out, but this comment alone essentially changed my viewpoint on this issue.
>Memories are bunk, is my point. Only media can really record history.

I don't trust media because Berenstein bears is the proper spelling [0]. I died when I was 6 years old after an asthma attack and shifted into another timeline where I survived. It shares most of the same details but likes to throw a few typos in to check if I'm paying attention. I'm not sure the purpose of these tests, but I'm sure I'll figure it out.

[0] https://en.wikipedia.org/wiki/Confabulation#Mandela_effect

/s

While confabulation is a severe problem with human memory, I don't trust media because history is written by the winners.
And where is the website hosted? If you're on AWS, guess what, Amazon is decrypting the traffic, not the website owner.

Calling Cloudflare MITM but not Amazon is just demonstrating that you haven't thought carefully about how professional service providers work together to deliver a website.

The certificate authenticates that you are seeing the website that the website owner intended you to see. If the website owner hires Cloudflare as a professional service provider, that premise is not violated!
I am team lead at a big corp and have 5 to 20 hours a week. It's pretty crazy with a lot of meetings with too many participants without clear goals or outcomes. It's mainly the meetings with other departments that take a lot of time without results. Within R&D most meetings are productive.

Line managers seem to spend most of their time in meetings.
I think they should be allowed to buy the homes, but then face stiff property taxes (with a homestead exemption for actual residents). The property taxes on Billionaire's Row in NYC are often absurdly low:

http://www.citylab.com/housing/2015/05/why-billionaires-dont...
Apple needs to provide an API to allow developers to cancel a subscription on a user's behalf. Currently, the only way to do this is through the app store, and many customers find this very confusing, resulting in poor customer experience and a heavy support burden on developers.

Many customers forget where they even sourced their subscription to begin with, especially if you have a multi-/omni-channel presence.
I was referring more to the creepy/invasive nature of the ad companies than the NSA, but I suppose that applies too.

Remember that I mentioned malware too - that is a very tangible risk, to my computer and any computer that it's connected to. I'm not speaking hyperbolically here either, malware loaded advertising winds up on large ad networks used on reputable sites[1].

My personal policy remains unchanged: when the site owner takes responsibility for what their server does to my computer (including reimbursement for time and materials when an infection shows up), I'll consider unblocking the ads, and not a moment before.

As it stands, the person who takes that snippet of Javascript from Adsense and ignorantly whacks it into their page wants all of the benefit (ad $$$) with none of the responsibility.

[1]: https://en.wikipedia.org/wiki/Malvertising#History
The general counterargument to the "we're in a bubble" observation has been that it's all private equity, that people aren't risking their houses or 401(k)s on startups this time around. This would appear to be a move in that direction.
We have no idea, who can send 10M followers per 2 days except Twitter
They probably don't want any more of a paper trail leading back to them than they have to.
Squatters seem like they would cause a problem. These places probably have staffs for the upkeep though.
...I'm an internet hero?
Not sure if the parent was trying to communicate this or not, but I think the core of the problem is really that alternative view points (ie. comments to discussion threads) get purposely buried, not necessarily the encompassing discussion thread. So sometimes it feels like we are missing out on varied and interesting comments because they aren't inline with the most prevalent viewpoint of the HN community.
He gave a testimony to Congress 3 years ago in which he complained about the tax rate. I hardly think this signal will do anything, well all know the one candidate that publicly called for lower corporate taxes and Cook didn't fundraiser for that guy...
The data is sharded by customer and then sub-sharded by end user within the customer. For all but the tiny customers, 100% of the data on a logical shard will belong to the same customer. That means our subqueries will never touch data from more than one customer unless the customer is very small. (And, if the customer is that small, it should be easy to make the query fast anyway.)
A colleague has a cousin that owns at least a couple of properties like this.

The penthouse apartment was available at all times to impress visitors (e.g. my colleague), and included a chauffeur who acted as a tour guide. The owner used it himself occasionally, if he was visiting the city for a business trip.
Applies to both bees, and ants. (And related species, wasps, hornets, et. al.)

https://en.wikipedia.org/wiki/Hymenoptera
The point is that the trustlesness is not needed for the applications mentioned in the original report.

Also they probably don't want Proof of Work for its wastefulness.
Too much! To me, it doesn't matter how short the meetings are, even a short meeting is disruptive. My new manager is really excellent, though. She has moved all our meetings to Mondays and it is now very manageable.
Joe Public Servant is one of the "GS plebs" I was referring to. Sure, some junior Congresscritter is going to get in more trouble than a SecState, but it will still be quite a bit less trouble than the random unelected staffer who will likely get scapegoated for said Congresscritter's transgression.
I agree that vacuous comment are ruthless downvoted as they should be.

But observations, even with high grade citations that criticize the libertarian narrative are also regularly down voted to oblivion.

Likewise any criticism of Russia gets clobber very quickly no matter how much evidence is offered.

[edit] likewise pointing out either of those two problems

So yes, poor post are down voted very efficiently but there is still a genuine problem with downvoting to hide information that parties don't want spread.